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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Changing context of walking behaviour: Impacts of movement restrictions in the urban neighbourhoods coping with the COVID-19 Pandemic</strong> -
<div>
Recent theoretical and empirical urban planning studies suggest that the availability of daily amenities, such as shopping stores, health care units, education services, pharmacies, within a 15-20-minute walking distance can keep daily life flux and also bring physical activities to individuals coping with the movement limitations of lockdowns during the COVID-19 Pandemic. This paper focuses on the relationship between neighborhood walkability and the changing walking behavior of 514 individuals during these lockdowns. The spatial context of this relationship highlights three main urban design aspects of the novel and innovative urban neighborhood planning: walkable access, spatial proximity, and social cohesion. This study demonstrates how restrictions imposed by the COVID-19 Pandemic affect the walking behaviors of the individuals, within 15-20 minute walkable and non-walkable neighborhoods located in different socio-economic geographies from American, European, Asian, Western Pacific, African, and Eastern Mediterranean cities. The discussion section of the methodology is supported by a survey questionnaire conducted in 24 disparate neighborhoods. Our data obtained from survey questionnaires is indicating that lockdown restrictions during the Pandemic influenced the walking purpose. Research findings also reflect limitations during the Pandemic complicate individuals’ requiring access to amenities in urban neighborhoods. With a nod to future studies on this topic, this paper proposes a basic framework as well as a thematic analysis with superimposed polar matrix charts.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/69n4m/" target="_blank">Changing context of walking behaviour: Impacts of movement restrictions in the urban neighbourhoods coping with the COVID-19 Pandemic</a>
</div></li>
<li><strong>Drug markets and COVID-19: A spatiotemporal study of drug offence detection rates in Brisbane, Australia</strong> -
<div>
In many parts of the world, the social mobility restrictions and stay-at-home orders introduced during the early months of the COVID-19 pandemic have been associated with significant reductions in crime. However, contrary to this general finding, illicit drug offence detections increased significantly. In this study, we explore the geographical distribution of the increase in Queensland, Australia, using spatiotemporal generalised additive model (GAM) to identify locations in the Local Government Area (LGA) of Brisbane where drug offence detection rates were unusually high during the three months of the COVID-19 lockdown (April-June 2020). Contrary to expectation, we find that the increase in drug offence detection rates appears to have been modest in most places, but widespread and diffuse throughout the city. We conclude that drug offence detections are most likely to have increased incidentally, probably as a consequence of general street policing initiatives which saw an increase in the visibility and vulnerability of drug user communities. We do, however, identify five locations in Brisbane where the drug offence detection rate exceeded the prediction by a considerable margin (in one case, more than double the worst case prediction). We argue that in these locations the increase was likely the result of some spatial displacement of inner-city drug markets coupled with a series of targeted policing activities. Further research is needed to clarify the true mechanism of change in these locations.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/2bxyw/" target="_blank">Drug markets and COVID-19: A spatiotemporal study of drug offence detection rates in Brisbane, Australia</a>
</div></li>
<li><strong>Isolation of SARS-CoV-2 B.1.1.28.2 P2 variant and pathogenicity comparison with D614G variant in hamster model</strong> -
<div>
Background: Considering the potential threat from emerging SARS-CoV-2 variants and the rising COVID-19 cases, SARS-CoV-2 genomic surveillance is ongoing in India. We report herewith the isolation of the P.2 variant (B.1.1.28.2) from international travelers and further its pathogenicity evaluation and comparison with D614G variant (B.1) in hamster model. Methods: Virus isolation was performed in Vero CCL81 cells and genomic characterization by next generation sequencing. The pathogenicity of the isolate was assessed in Syrian hamster model and compared with B.1 variant. Results: B.1.1.28.2 variant was isolated from nasal/throat swabs of international travelers returned to India from United Kingdom and Brazil. The B.1.1.28.2 variant induced body weight loss, viral replication in the respiratory tract, lung lesions and caused severe lung pathology in infected Syrian hamster model in comparison, with B.1 variant infected hamsters. The sera from B.1.1.28.2 infected hamsters efficiently neutralized the D614G variant virus whereas 6-fold reduction in the neutralization was seen in case of D614G variant infected hamsters sera with the B.1.1.28.2 variant. Conclusions: B.1.1.28.2 lineage variant could be successfully isolated and characterization could be performed. Pathogenicity of the isolate was demonstrated in Syrian hamster model and in comparison, with B.1 variant was found more pathogenic. The findings of increased disease severity and neutralization reduction is of great concern and point towards the need for screening the vaccines for efficacy.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.24.445424v1" target="_blank">Isolation of SARS-CoV-2 B.1.1.28.2 P2 variant and pathogenicity comparison with D614G variant in hamster model</a>
</div></li>
<li><strong>Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core</strong> -
<div>
The molecular events that permit the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to bind, fuse, and enter cells are important to understand for both fundamental and therapeutic reasons. Spike proteins consist of S1 and S2 domains, which recognize angiotensin-converting enzyme 2 (ACE2) receptors and contain the viral fusion machinery, respectively. Ostensibly, the binding of spike trimers to ACE2 receptors promotes the preparation of the fusion machinery by dissociation of the S1 domains. We report the development and use of coarse-grained models and simulations to investigate the dynamical mechanisms involved in viral binding and exposure of the S2 trimeric core. We show that spike trimers cooperatively bind to multiple ACE2 dimers. The multivalent interaction cyclically and processively induces S1 dissociation, thereby exposing the S2 core containing the fusion machinery. Our simulations thus reveal an important concerted interaction between spike trimers and ACE2 dimers that primes the virus for membrane fusion and entry.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.24.445443v1" target="_blank">Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core</a>
</div></li>
<li><strong>Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative</strong> -
<div>
The Receptor Binding Domain (RBD) of SARS-CoV-2 is the primary target of neutralizing antibodies. We designed a trimeric, highly thermotolerant glycan engineered RBD by fusion to a heterologous, poorly immunogenic disulfide linked trimerization domain derived from cartilage matrix protein. The protein was expressed at a yield of ~80-100 mg/liter in transiently transfected Expi293 cells, as well as in CHO and HEK293 stable cell lines, and formed homogeneous disulfide-linked trimers. When lyophilized, the trimer possessed remarkable functional stability to transient thermal stress of upto 100 {degrees}C and was stable to long term storage of over 4 weeks at 37 {degrees}C unlike an alternative RBD-trimer with a different trimerization domain. Two intramuscular immunizations with a human-compatible SWE adjuvanted formulation, elicited antibodies with neutralizing titers in guinea pigs and mice that were 25-250 fold higher than the corresponding values in human convalescent sera. Against the B.1.351 South African variant, neutralization titers for RBD trimer and human convalescent sera were ~ three-fold and greater than fourteenfold lower respectively. RBD was also displayed on a designed ferritin-like Msdps2 nanoparticle but this showed decreased yield and immunogenicity relative to trimeric RBD. Trimeric RBD immunized hamsters were protected from viral challenge. The excellent immunogenicity, thermotolerance, and high yield of such trimeric RBD immunogens suggest that they are a promising modality to combat COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.13.426626v2" target="_blank">Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative</a>
</div></li>
<li><strong>Evidence for Deleterious Original Antigenic Sin in SARS-CoV-2 Immune Response</strong> -
<div>
A previous report demonstrated the strong association between the presence of antibodies binding to an epitope region from SARS-CoV-2 nucleocapsid, termed Ep9, and COVID-19 disease severity. Patients with anti-Ep9 antibodies (Abs) had hallmarks of original antigenic sin (OAS), including early IgG upregulation and cytokine-associated injury. Thus, the immunological memory of a previous infection was hypothesized to drive formation of suboptimal anti-Ep9 Abs in severe COVID-19 infections. This study identifies a putative original antigen capable of stimulating production of cross-reactive, anti-Ep9 Abs. From bioinformatics analysis, 21 potential original epitope regions were identified. Binding assays with patient blood samples directly show cross-reactivity between Abs binding to Ep9 and only one homologous potential antigen, a sequence derived from the neuraminidase protein of H3N2 Influenza A virus. This cross-reactive binding affinity is highly virus strain specific and sensitive to even single amino acid changes in epitope sequence. The neuraminidase protein is not present in the influenza vaccine, and the anti-Ep9 Abs likely resulted from the widespread influenza infection in 2014. Therefore, OAS from a previous infection could underlie some cases of COVID-19 disease severity and explain the diversity observed in disease outcomes.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.21.445201v1" target="_blank">Evidence for Deleterious Original Antigenic Sin in SARS-CoV-2 Immune Response</a>
</div></li>
<li><strong>Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates</strong> -
<div>
Background: Vaccine efficacy against the B.1.351 variant following mRNA-1273 vaccination in humans has not been determined. Nonhuman primates (NHP) are a useful model for demonstrating whether mRNA-1273 mediates protection against B.1.351. Methods: Nonhuman primates received 30 or 100 microgram of mRNA-1273 as a prime-boost vaccine at 0 and 4 weeks, a single immunization of 30 microgram at week 0, or no vaccine. Antibody and T cell responses were assessed in blood, bronchioalveolar lavages (BAL), and nasal washes. Viral replication in BAL and nasal swabs were determined by qRT-PCR for sgRNA, and histopathology and viral antigen quantification were performed on lung tissue post-challenge. Results: Eight weeks post-boost, 100 microgram x2 of mRNA-1273 induced reciprocal ID50 neutralizing geometric mean titers against live SARS-CoV-2 D614G and B.1.351 of 3300 and 240, respectively, and 430 and 84 for the 30 microgram x2 group. There were no detectable neutralizing antibodies against B.1351 after the single immunization of 30 microgram. On day 2 following B.1.351 challenge, sgRNA in BAL was undetectable in 6 of 8 NHP that received 100 microgram x2 of mRNA-1273, and there was a ~2-log reduction in sgRNA in NHP that received two doses of 30 microgram compared to controls. In nasal swabs, there was a 1-log10 reduction observed in the 100 microgram x2 group. There was limited inflammation or viral antigen in lungs of vaccinated NHP post-challenge. Conclusions: Immunization with two doses of mRNA-1273 achieves effective immunity that rapidly controls lower and upper airway viral replication against the B.1.351 variant in NHP.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.21.445189v1" target="_blank">Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates</a>
</div></li>
<li><strong>Interplay between protein stability, binding to ACE2 and escape from neutralizing antibodies determines the natural selection of SARS-CoV-2 receptor binding domain variants</strong> -
<div>
Emergence of new SARS-CoV-2 variants has raised concerns at the effectiveness of vaccines and antibody therapeutics developed against the unmutated wild-type virus. It is thus important to understand the emergence of mutants from an evolutionary viewpoint to be able to devise effective countermeasures against new variants. We examined the effect of 12 most commonly occurring mutations in the receptor binding domain (RBD) on its expression, stability, activity, and antibody escape potential- some of the factors that may influence the natural selection of mutants. Recombinant proteins were expressed in human cells. Stability was measured using thermal denaturation melts. Activity and antibody escape potential were measured using isothermal titration calorimetry in terms of binding of RBD variants to ACE2 and to a neutralizing human antibody CC12.1, respectively. Our results show that variants differ in their expression levels, suggesting that mutations can impact the availability of proteins for virus assembly. All variants have similar or higher stability than the wild-type, implying that increased RBD stability might be another important factor in virus evolution. In terms of ACE2 binding, when compared to the wild-type, only 3 out of 7 expressed variants show stronger affinity, 2 have similar affinity, whereas the other 2 have weaker affinity, indicating that increased affinity towards ACE2 is an important but not the sole factor in the natural selection of variants. In terms of CC12.1 binding, when compared to the wild-type, 4 out of 7 variants have weaker affinity, 2 have a similar affinity, and 1 variant has a stronger affinity. Taken together, these results indicate that multiple factors contribute towards the natural selection of variants, and all of these factors have to be considered in order to understand the natural selection of SARS-CoV-2 variants. In addition, since not all variants can escape a given neutralizing antibody, antibodies to treat new variants can be chosen based on the specific mutations in that particular variant.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.23.445348v1" target="_blank">Interplay between protein stability, binding to ACE2 and escape from neutralizing antibodies determines the natural selection of SARS-CoV-2 receptor binding domain variants</a>
</div></li>
<li><strong>Unsupervised explainable AI for the collective analysis of a massive number of genome sequences: various examples from the small genome of pandemic SARS-CoV-2 to the human genome</strong> -
<div>
In genetics and related fields, huge amounts of data, such as genome sequences, are accumulating, and the use of artificial intelligence (AI) suitable for big data analysis has become increasingly important. Unsupervised AI that can reveal novel knowledge from big data without prior knowledge or particular models is highly desirable for analyses of genome sequences, particularly for obtaining unexpected insights. We have developed a batch-learning self-organizing map (BLSOM) for oligonucleotide compositions that can reveal various novel genome characteristics. Here, we explain the data mining by the BLSOM: unsupervised and explainable AI. As a specific target, we first selected SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) because a large number of the viral genome sequences have been accumulated via worldwide efforts. We analyzed more than 0.6 million sequences collected primarily in the first year of the pandemic. BLSOMs for short oligonucleotides (e.g., 4~6-mers) allowed separation into known clades, but longer oligonucleotides further increased the separation ability and revealed subgrouping within known clades. In the case of 15-mers, there is mostly one copy in the genome; thus, 15-mers appeared after the epidemic start could be connected to mutations. Because BLSOM is an explainable AI, BLSOM for 15-mers revealed the mutations that contributed to separation into known clades and their subgroups. After introducing the detailed methodological strategies, we explained BLSOMs for various topics. The tetranucleotide BLSOM for over 5 million 5-kb fragment sequences derived from almost all microorganisms currently available and its use in metagenome studies. We also explained BLSOMs for various eukaryotes, such as fishes, frogs and Drosophila species, and found a high separation ability among closely related species. When analyzing the human genome, we found evident enrichments in transcription factor-binding sequences (TFBSs) in centromeric and pericentromeric heterochromatin regions. The tDNAs (tRNA genes) were separated by the corresponding amino acid.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.23.445371v1" target="_blank">Unsupervised explainable AI for the collective analysis of a massive number of genome sequences: various examples from the small genome of pandemic SARS-CoV-2 to the human genome</a>
</div></li>
<li><strong>How did COVID-19 measures impact sexual behaviour and access to HIV/STI services in Panama? Results from a national cross-sectional online survey</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives To describe perceived changes in sexual behaviours, including virtual sex (sexting and cybersex), and access to HIV/STI testing and care during COVID-19 measures in Panama. Methods We conducted an online cross-sectional survey from August 8 to September 12, 2020, among adults (≥18 years) residing in Panama. Participants were recruited through social media. Questions included demographics, access to HIV/STI testing and HIV care and sexual behaviours three months before COVID-19 social distancing measures and during social distancing measures (COVID-19 measures). Logistic regression was used to identify associations between variables and behavioural changes. Results We recruited 960 participants; 526 (54.8%) identified as cis-women, 366 (38.1%) cis-men, and 68 (7.1%) non-binary or another gender; median age was 28y (IQR:23-37y), 531/957 (55.5%) were of mixed-ethnicity (mixed-Indigenous/European/Afro-descendant ancestry). Before COVID-19 measures, virtual sex was reported by 38.5% (181/470) cis-women, 58.4% (184/315) cis-men and 45.0% (27/60) non-binary participants; during COVID-19 measures, virtual sex increased among 17.2% cis-women, 24.7% cis-men and 8.9% non-binary participants. During COVID-19 measures, 230/800 [28.8%] of participants reported decreased casual sex compared to pre-COVID-19 measures. Compared to pre-COVID-19 measures, decreased casual sex were reported more frequently during COVID-19 measures by cis-men compared to cis-women (39.2% versus 22.9%, urban/rural adjusted odds ratio [AOR]=2.17, 95% confidence interval [CI]:1.57-3.01); and by Afro-descendant compared to mixed-ethnicity participants (40.0% versus 29.8%, AOR=1.78, 95%CI:1.07-2.94). Compared to no change in virtual sex (16.8%), increase in virtual sex (38.5%, AOR=1.78, 95%CI:1.10-2.88); and decreased virtual sex (86.7%, AOR=16.53, 95%CI:7.74-35.27) were associated with decreased casual sex encounters. During COVID-19 measures, HIV/STI testing could not be obtained by 58.0%(58/100) participants who needed a test, and interrupted HIV care was reported by 53.3% (8/15) HIV-positive participants. Conclusions COVID-19 measures in Panama were associated with a decrease in casual sex among cis-men and Afro-descendant peoples, whilst access to HIV/STI testing and care was seriously disrupted.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.03.21251095v2" target="_blank">How did COVID-19 measures impact sexual behaviour and access to HIV/STI services in Panama? Results from a national cross-sectional online survey</a>
</div></li>
<li><strong>The epidemic of ‘Black fungus’ (mucormycosis) in Covid19 patients in India - a perfect synergy between immuno-suppressive drugs and supportive oxygen that promotes the bio-syntheses of ergosterol (a key component of fungal cell membranes)?</strong> -
<div>
The “black fungus” (mucormycosis) epidemic in India in April-May 2021 [1] has exacerbated the Covid19 problem, and has been ascribed to over-usage of immuno-suppressive drugs (steroids) and uncontrolled diabetes [2]. This however does not answer the whole question, since these steroids are regularly prescribed for many diseases like RA, and even in the previous year (2020) in India for Covid19 patients. So what changed? Another (troubling) feature of the 2021 Covid19 wave in India has been the requirement (and often un- fortunately lack) of supportive oxygen. However, hypoxia (lack of oxygen) is a double-edged sword during pathogenesis [3], as hypoxia at infection sites creates a stressful environment for many host and pathogens. It has been realized that ‘manipulation of oxygen levels and/or oxygen-mediated signaling pathways in vivo may have both positive and negative effects on the outcome of’ fungal infections [4]. For example, Mucor irregularis has ways to circumvent the hypoxic environment, and thrives in skin where oxygen is minimal [5]. The treatment Amphotericin provides the link - Ergosterol ‘Amphotericin primarily kills yeast by simply binding ergosterol’ [6]. Ergosterol is an essential component of cell membranes of fungi and protozoa, analogous to cholesterol in animal cells [7]. Ergosterol biosynthesis requires oxygen [8]. And in low oxygen, cells that cannot make ergosterol absorb it from the external culture environment [9]. When oxygen is in abundance, cells use ergosterol which they biosynthesize [9]. More feedback? ‘Ergosterol, which is structurally analogous to cholesterol, has been used as a precursor of vitamin D2 and steroid hormone drugs’ [10]. Why not other fungi? Oxygen level of the environment modulates the several genes of Mucor [11], while transcriptional profiling showed that the lipid metabolism was more active under hypoxia [12]. Maybe other fungi are not that adapt in reverting back to an aerobic environment, like Mucor. The evolution of sterols as an adaptive response to the rise of terrestrial oxygen has been proposed [13]. Is is possible the Mucor has best retained this primitive response to oxygen stress?
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/pbnwy/" target="_blank">The epidemic of ‘Black fungus’ (mucormycosis) in Covid19 patients in India - a perfect synergy between immuno-suppressive drugs and supportive oxygen that promotes the bio-syntheses of ergosterol (a key component of fungal cell membranes)?</a>
</div></li>
<li><strong>Comparison of Catastrophizing and Perceived Stress in Three Groups of COVID-19 Patients Recovered</strong> -
<div>
The aim of this study was to compare catastrophizing and perceived stress in three groups of Covid-19 patients recovered. This was a descriptive study. The statistical population of this study was the visitors of Avaye Dousti Clinic psychometrics system from October to December 2020. From this population, 97 people who met the inclusion criteria was positive, were selected by purposive sampling method. Volunteers were divided into three groups: patients with respiratory symptoms and hospitalized (n=22), patients with respiratory symptoms and non-hospitalized (n=27) and patients without respiratory symptoms and non-hospitalized (n=48). Measurement tools of this study included Sullivan (2009) catastrophizing Questionnaire and Cohen et al (1983) Perceived Stress Questionnaire. Data were analyzed by analysis of variance using. The results showed that catastrophizing, mental rumination, helplessness and magnification were not significantly different, between the group with respiratory symptoms and hospitalized and the group with respiratory symptoms and non-hospitalized (p&gt; 0.05), but the same variables in the group without respiratory symptoms and non-hospitalized, Was less than the two groups (p &lt;0.05). Perceived stress was not significantly different between the three groups (p&gt; 0.05). The findings of this study showed that catastrophizing in patients with Covid-19 disease is seen in patients with more severe symptoms for at least a few months after recovery and high perceived stress was observed in all patients without significant differences.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/mc98f/" target="_blank">Comparison of Catastrophizing and Perceived Stress in Three Groups of COVID-19 Patients Recovered</a>
</div></li>
<li><strong>Why women empowerment is needed post COVID-19?</strong> -
<div>
The dreadful COVID-19 pandemic has brought forth many harsh realities. This has affected men and women differently. As it is, women already suffer the fate of the lesser gender due to the prevalent patriarchal society. The ongoing outbreak has increased this divide. Women face many challenges be it in urban or rural area, middle or low-income group; the issues differ to an extent, but they exist. The roles as defined by the social norms have become more prominent. This paper attempts to study the various consequences of the COVID-19 pandemic on women and men. It provides an assessment as to why women empowerment is the need of the hour and tries to find probable solutions to the pertaining problems. Education and financial independence are two primary ways of empowerment at individual level. As a society, we need to rethink and revamp the values, beliefs, attitudes towards gender norms and predefined roles. We need to make changes at the grass root level to bring in equality. Global social transformation is required in order to weaken the deep-rooted patriarchy.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/jkxd7/" target="_blank">Why women empowerment is needed post COVID-19?</a>
</div></li>
<li><strong>Study of relationship between optimism and resilience in the times of COVID-19 among university students</strong> -
<div>
The purpose of present research is to study the effect of COVID-19 Pandemic on the relationship between Optimism and Resilience among the university students. Optimism and Resilience of 100 university students (36 males and 64 females) were assessed by using optimism pessimism scale and a brief resilience scale. Digital survey method was adopted to reach out to the university students between 18-23 yrs. of age group and Pearson correlation coefficient method was used to establish the relationship between the variables. As a result, it was found that optimism and resilience share a positive relationship (0.507) not only otherwise but in the challenging times too. Findings revealed that to increase the resilience one has to increase the positive and optimistic thoughts. The research can add value to the detailed study on optimism and its relation with resilience and psychological well-being during unforeseen period. This study also gives further opportunity for a comparative study between the optimism and resilience among different age groups.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/5a3gs/" target="_blank">Study of relationship between optimism and resilience in the times of COVID-19 among university students</a>
</div></li>
<li><strong>Effectiveness of COVID-19 vaccines against the B.1.617.2 variant</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The B.1.617.2 COVID-19 variant has contributed to the surge in cases in India and has now been detected across the globe, including a notable increase in cases in the UK. We estimate the effectiveness of the BNT162b2 and ChAdOx1 COVID-19 vaccines against this variant. Methods: A test negative case control design was used to estimate the effectiveness of vaccination against symptomatic disease with both variants over the period that B.1.617.2 began circulating with cases identified based on sequencing and S-gene target status. Data on all symptomatic sequenced cases of COVID-19 in England was used to estimate the proportion of cases with B.1.617.2 compared to the predominant strain (B.1.1.7) by vaccination status. Results: Effectiveness was notably lower after 1 dose of vaccine with B.1.617.2 cases 33.5% (95%CI: 20.6 to 44.3) compared to B.1.1.7 cases 51.1% (95%CI: 47.3 to 54.7) with similar results for both vaccines. With BNT162b2 2 dose effectiveness reduced from 93.4% (95%CI: 90.4 to 95.5) with B.1.1.7 to 87.9% (95%CI: 78.2 to 93.2) with B.1.617.2. With ChAdOx1 2 dose effectiveness reduced from 66.1% (95% CI: 54.0 to 75.0) with B.1.1.7 to 59.8% (95%CI: 28.9 to 77.3) with B.1.617.2. Sequenced cases detected after 1 or 2 doses of vaccination had a higher odds of infection with B.1.617.2 compared to unvaccinated cases (OR 1.40; 95%CI: 1.13-1.75). Conclusions: After 2 doses of either vaccine there were only modest differences in vaccine effectiveness with the B.1.617.2 variant. Absolute differences in vaccine effectiveness were more marked with dose 1. This would support maximising vaccine uptake with two doses among vulnerable groups.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.05.22.21257658v1" target="_blank">Effectiveness of COVID-19 vaccines against the B.1.617.2 variant</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recombinant Hyperimmune Polyclonal Antibody (GIGA-2050) in COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: GIGA-2050<br/><b>Sponsor</b>:   GigaGen, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Effects of RO7496998 (AT-527) in Non-Hospitalized Adult and Adolescent Participants With Mild or Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: RO7496998;   Drug: Placebo<br/><b>Sponsors</b>:   Atea Pharmaceuticals, Inc.;   Hoffmann-La Roche<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Vitamin D Supplementation on COVID-19 Recovery</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Vit-D 0.2 MG/ML Oral Solution [Calcidol];   Drug: Physiological Irrigating Solution<br/><b>Sponsors</b>:   University of Monastir;   Loussaief Chawki;   Nissaf Ben Alaya;   Cyrine Ben Nasrallah;   Manel Ben Belgacem;   Hela Abroug;   Imen Zemni;   Manel Ben fredj;   Wafa Dhouib<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Using Text Messages to Improve COVID-19 Vaccination Uptake</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Behavioral: Text message content<br/><b>Sponsors</b>:   Imperial College Healthcare NHS Trust;   Central London CCG;   Imperial College Health Partners;   Institute for Global Health Innovations;   The Behavioural Insights Team<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Safety and Effect of STC3141 Continuous Infusion in Subjects With Severe Corona Virus Disease 2019（COVID-19）Pneumonia</strong> - <b>Condition</b>:   Severe COVID-19 Pneumonia<br/><b>Intervention</b>:   Drug: STC3141<br/><b>Sponsors</b>:   Grand Medical Pty Ltd.;   Trium Clinical Consulting<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Ivermectin;   Other: Placebo<br/><b>Sponsor</b>:   Ministry of Public Health, Argentina<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mix and Match of the Second COVID-19 Vaccine Dose for Safety and Immunogenicity</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: mRNA-1273 SARS-CoV-2 vaccine;   Biological: BNT162b2;   Biological: ChAdOx1-S [recombinant];   Other: 0, 28 day schedule;   Other: 0, 112 day schedule<br/><b>Sponsors</b>:   Canadian Immunization Research Network;   Canadian Center for Vaccinology;   BC Children’s Hospital Research Institute;   Children’s Hospital Research Institute of Manitoba;   CHU de Quebec-Universite Laval;   Ottawa Hospital Research Institute;   Northern Alberta Clinical Trials + Research Centre;   Ontario Agency for Health Protection and Promotion;   University of Toronto;   Massachusetts General Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Role of High Dose Co-trimoxazole in Severe Covid-19 Patients</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: Co-trimoxazole;   Drug: Placebo<br/><b>Sponsor</b>:   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti COVID 19 Intravenous Immunoglobulin (C-IVIG) Therapy for Severe COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: Anti COVID 19 Intravenous Immunoglobulin (C-IVIG)<br/><b>Sponsors</b>:   Dow University of Health Sciences;   Higher Education Commission (Pakistan)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CRP-Apheresis for Attenuation of Pulmonary, MYocardial and/or Kidney Injury in COvid-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Device: CRP-apheresis<br/><b>Sponsor</b>:   University Hospital, Essen<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Biological: Mesenchymal Stem Cells Transplantation<br/><b>Sponsors</b>:   SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi;   Istinye University;   Liv Hospital (Ulus)<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Global Phase III Clinical Trial of Recombinant COVID-19 Vaccine (Sf9 Cells)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 vaccine (Sf9 cells);   Other: Placebo control<br/><b>Sponsors</b>:   Jiangsu Province Centers for Disease Control and Prevention;   WestVac Biopharma Co., Ltd.;   West China Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACTIV-6: COVID-19 Study of Repurposed Medications</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Ivermectin Tablets<br/><b>Sponsors</b>:   Susanna Naggie, MD;   National Center for Advancing Translational Science (NCATS);   Vanderbilt University Medical Center<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amantadine for COVID-19: A Randomized, Placebo Controlled, Double-blinded, Clinical Trial</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Amantadine;   Drug: Lactose monohydrate<br/><b>Sponsors</b>:   Copenhagen University Hospital, Hvidovre;   University of Copenhagen<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>3R Rehabilitation Management of COVID-19 Survivors</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Cardiopulmonary exercise (centre-based);   Other: Cardiopulmonary exercise (online-based)<br/><b>Sponsors</b>:   The Hong Kong Polytechnic University;   Pamela Youde Nethersole Eastern Hospital, Hong Kong;   Queen Elizabeth Hospital, Hong Kong;   Princess Margaret Hospital, Hong Kong;   Tuen Mun Hospital Hong Kong<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Arginine Methylation of SARS-Cov-2 Nucleocapsid Protein Regulates RNA Binding, its Ability to Suppress Stress Granule Formation and Viral Replication</strong> - Viral proteins are known to be methylated by host protein arginine methyltransferases (PRMTs) necessary for the viral life cycle, but it remains unknown whether SARS-CoV-2 proteins are methylated. Herein, we show that PRMT1 methylates SARS-CoV-2 nucleocapsid (N) protein at residues R95 and R177 within RGG/RG motifs, preferred PRMT target sequences. We confirmed arginine methylation of N protein by immunoblotting viral proteins extracted from SARS-CoV-2 virions isolated from cell culture. Type I…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Binding mode characterization of 13b in the monomeric and dimeric states of SARS-CoV-2 main protease using molecular dynamics simulations</strong> - The main protease, M<sup>(pro)/3CL</sup>(pro), plays an essential role in processing polyproteins translated from viral RNA to produce functional viral proteins and therefore serve as an attractive target for discovering COVID-19 therapeutics. The availability of both monomer and dimer crystal bound with a common ligand, ‘13b’ (α-ketoamide inhibitor), opened up opportunities to understand the M^(pro) mechanism of action. A comparative analysis of both forms of M^(pro) was carried out to elucidate the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome</strong> - Programmed ribosomal frameshifting is a key event during translation of the SARS-CoV-2 RNA genome allowing synthesis of the viral RNA-dependent RNA polymerase and downstream proteins. Here we present the cryo-electron microscopy structure of a translating mammalian ribosome primed for frameshifting on the viral RNA. The viral RNA adopts a pseudoknot structure that lodges at the entry to the ribosomal mRNA channel to generate tension in the mRNA and promote frameshifting, whereas the nascent…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>High-performance antiviral nano-systems as a shield to inhibit viral infections: SARS-CoV-2 as a model case study</strong> - Despite significant accomplishments in developing efficient rapid sensing systems and nano-therapeutics of higher efficacy, the recent coronavirus disease (COVID-19) pandemic is not under control successfully because the severe acute respiratory syndrome virus (SARS-CoV-2, original and mutated) transmits easily from human to -human and causes life-threatening respiratory disorders. Thus, it has become crucial to avoid this transmission through precautions and keep premises hygienic using…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comparison of the coagulopathies associated with COVID-19 and sepsis</strong> - CONCLUSIONS: High levels of both EVTF activity and active PAI-1 may promote thrombosis in patients with COVID-19 due to simultaneous activation of coagulation and inhibition of fibrinolysis. The high levels of active PAI-1 in patients with COVID-19 may limit plasmin degradation of crosslinked fibrin and the release of d-dimer. This may explain the lower levels of D-dimer in patients with COVID-19 compared with patients with sepsis.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Interleukin-13 as a target to alleviate severe coronavirus disease 2019 and restore lung homeostasis</strong> - The ongoing coronavirus disease (COVID-19) pandemic urgently requires the availability of interventions that improve outcomes for those with severe disease. Since severe acute respiratory syndrome coronavirus 2 infection is characterized by dysregulated lung mucosae, and that mucosal homeostasis is heavily influenced by interleukin (IL)-13 activity, we explore recent findings indicating that IL-13 production is proportional to disease severity. We propose that excessive IL-13 contributes to the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico Approach</strong> - SARS-CoV-2 infection across the world has led to immense turbulence in the treatment modality, thus demanding a swift drug discovery process. Spike protein of SARS-CoV-2 binds to ACE2 receptor of human to initiate host invasion. Plethora of studies demonstrate the inhibition of Spike-ACE2 interactions to impair infection. The ancient Indian traditional medicine has been of great interest of Virologists worldwide to decipher potential antivirals. Hence, in this study, phytochemicals (1,952…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19</strong> - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) through excessive end organ inflammation. Despite improved understanding of the pathophysiology, management, and the great efforts worldwide to produce effective drugs, death rates of COVID-19 patients remain unacceptably high, and effective treatment is unfortunately lacking. Pharmacological strategies aimed at modulating inflammation in COVID-19 are being evaluated worldwide….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Calendulaglycoside A Showing Potential Activity Against SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and SAR Studies</strong> - BACKGROUND AND AIM: The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To this end, natural products can provide therapeutic alternatives that could be employed as an effective safe treatment for COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of (E)-N-(4-cyanobenzylidene)- 6-fluoro- 3-hydroxypyrazine-2 -carboxamide (cyanorona-20): the first potent and specific anti-COVID-19 drug</strong> - ABSTRACT: Specific inhibition of the viral RNA-dependent RNA polymerase (RdRp) of the newly-emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising strategy for developing highly potent medicines for coronavirus disease 2019 (COVID-19). However, almost all of the reported viral RdRp inhibitors (either repurposed drugs or new antiviral agents) lack selectivity against the SARS-CoV-2 RdRp. Herein, I discovered a new favipiravir derivative,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin</strong> - The COVID-19 pandemic as the largest global public health crisis is now considered as an emergency at the World Health Organization (WHO). As there is no specific therapy for SARS-CoV-2 infection at present and also because of the long time it takes to discover a new drug and the urgent need to respond urgently to a pandemic infection. Perhaps the best way right now is to find an FDA-approved drug to treat this infection. Oxidative stress and inflammation play a vital role in the progression of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis</strong> - Higher selenium status has been shown to improve the clinical outcome of infections caused by a range of evolutionally diverse viruses, including SARS-CoV-2. However, the impact of SARS-CoV-2 on host-cell selenoproteins remains elusive. The present study investigated the influence of SARS-CoV-2 on expression of selenoprotein mRNAs in Vero cells. SARS-CoV-2 triggered an inflammatory response as evidenced by increased IL-6 expression. Of the 25 selenoproteins, SARS-CoV-2 significantly suppressed…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccines</strong> - A SARS-like coronavirus 2 (SARS-CoV-2) has caused a pandemic Coronavirus Disease 2019 (COVID-19) that killed more than 3.3 million people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of its spike protein to bind a host receptor, the angiotensin-converting enzyme 2 (ACE2), to gain entry. Currently, several mRNA or adenoviral vaccines encoding for the spike protein of SARS-CoV-2 are being used to boost antibodies capable of inhibiting spike-ACE2 interaction…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type III polyketide synthase</strong> - Antibiotic resistance and emerging viral pandemics have posed an urgent need for new anti-infective drugs. By screening our microbial extract library against the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the notorious ESKAPE pathogens, an active fraction was identified and purified, leading to an initial isolation of adipostatins A (1) and B (2). In order to diversify the chemical structures of adipostatins toward enhanced biological activities, a type III…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lipopeptide-based pan-CoV fusion inhibitors potently inhibit HIV-1 infection</strong> - No abstract</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA)</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323956811">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295937">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DEEP LEARNING BASED SYSTEM FOR DETECTION OF COVID-19 DISEASE OF PATIENT AT INFECTION RISK</strong> - The present invention relates to Deep learning based system for detection of covid-19 disease of patient at infection risk. The objective of the present invention is to solve the problems in the prior art related to technologies of detection of covid-19 disease using CT scan image processing. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN324122821">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A COMPREHENSIVE DISINFECTION SYSTEM DURING PANDEMIC FOR PERSONAL ITEMS AND PROTECTIVE EQUIPMENT (PPE) TO SAFEGUARD PEOPLE</strong> - The current Covid-19 pandemic has led to an enormous demand for gadgets / objects for personal protection. To prevent the spread of virus, it is important to disinfect commonly touched objects. One of the ways suggested is to use a personal UV-C disinfecting box that is “efficient and effective in deactivating the COVID-19 virus. The present model has implemented the use of a UV transparent material (fused silica quartz glass tubes) as the medium of support for the objects to be disinfected to increase the effectiveness of disinfection without compromising the load bearing capacity. Aluminum foil, a UV reflecting material, was used as the inner lining of the box for effective utilization of the UVC light emitted by the UVC lamps. Care has been taken to prevent leakage of UVC radiation out of the system. COVID-19 virus can be inactivated in 5 minutes by UVC irradiation in this disinfection box - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN322882412">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UBIQUITOUS COMPUTING SYSTEM FOR MENTAL HEALTH MONITORING OF PERSON DURING THE PANDEMIC OF COVID-19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295498">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USE OF IMINOSUGAR COMPOUND IN PREPARATION OF ANTI-SARS-COV-2 VIRUS DRUG</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU322897928">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种高灵敏SARS-CoV-2中和抗体的检测方法、检测试剂盒</strong> - 本发明公开了一种高灵敏SARS‑CoV‑2中和抗体的检测方法、检测试剂盒，属于生物医学检测技术领域，本发明试剂盒包括层析试纸、卡壳和样本稀释液，所述层析试纸包括底板、样品垫、结合垫、NC膜和吸水垫，所述NC膜上依次设置有捕获线、检测线和质控线，所述捕获线包被有ACE2蛋白，所述检测线包被有RBD蛋白，所述结合垫设置有RBD蛋白标记物；本发明采用阻断法加夹心法原理提高检测中和抗体的灵敏度，通过添加捕获线的方式，将靶向RBD的非中和抗体提前捕获，保证后续通过夹心法检测中和抗体的特异性。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN323798634">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>逆转录酶突变体及其应用</strong> - 本发明提供一种MMLV逆转录酶突变体，在野生型MMLV逆转录酶氨基酸序列（如SEQ ID No.1序列所示）中进行七个氨基酸位点的突变，氨基酸突变位点为：R205H；V288T；L304K；G525D；S526D；E531G；E574G。该突变体可以降低MMLV逆转录酶对Taq DNA聚合酶的抑制作用，大大提高了一步法RT‑qPCR的灵敏度。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN323494119">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Konstruktion einer elektrochemischen Atemmaske zum aktiven Schutz vor Coronavirus</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Konstruktion einer elektrochemischen medizinischen Atemmaske (1) für den aktiven Schutz gegen Infektion mit Coronaviren dadurch gekennzeichnet, dass ein elektrochemischer Effekt durch eine allgemein positives Magnetfeld der Maske erzeugbar ist, das die positiv geladenen Coronavirus-Mikroorganismen von der Person vertreibt, indem eine aktive elektrochemische Atemmaske (1) aus einem zweischichtigen Material verwendet wird, umfassend eine äußeren Schicht (2) aus einer hochmolekularen Verbindung aus Bambus in Mischung mit Kupfer-, Silber- oder Goldmetallfasern und einer inneren Schicht (3) aus einem Vliesstoff auf Basis von Polypropylenfasern SMS oder SNS, wobei der Maskenkörper aus zwei in der Mitte der Gesichtssymmetrie genähten Elementen gebildet ist, um die Kontur der Gesichtskurven so weit wie möglich zu wiederholen, ausgestattet mit einem Atemfilter (9) mit einem Einsatz aus zwei Schichten ferromagnetischen Metallgewebes, wobei das Filter (9) hat eine herausnehmbare SMS- oder SNS-Vlieskartusche in einem Kunststoffrand (14) und eine Öse zur Fixierung im Filtergehäuse umfasst, wobei die Maske (1) jeweils einen Nasen- und Kinnbügel aus einem flexiblen Einschubstreifen zwischen den beiden Lagen des Maskengewebes aufweist, die eine Fixierung auf Basis von doppelseitig klebendem Silikonklebeband in den Maskenseitenkanten sowie Nacken- und Kopfbefestigungsschlaufen ermöglichen.</p></li>
</ul>
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<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE324122059">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU321590214">link</a></p></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The High Price of a New York City Cop</strong> - One of the city’s star officers has cost taxpayers more than two and a half million dollars in police-misconduct settlements. - <a href="https://www.newyorker.com/news/our-local-correspondents/the-high-price-of-a-new-york-city-cop">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Hacking Became a Professional Service in Russia</strong> - The outfit behind the Colonial Pipeline attack had a blog, a user-friendly interface, and a sliding fee scale for helping hackers cash in on stolen information. - <a href="https://www.newyorker.com/news/news-desk/how-hacking-became-a-professional-service-in-russia">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eric Adams Wants to CompStat New York City</strong> - As a cop, he spoke out against police abuse. As a mayoral front-runner, he’s speaking up for the police. - <a href="https://www.newyorker.com/news/our-local-correspondents/eric-adams-wants-to-compstat-new-york-city">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bitcoin’s Troubles Go Far Beyond Elon Musk</strong> - Recent moves by China have exposed the vulnerability of the cryptocurrency. - <a href="https://www.newyorker.com/news/our-columnists/bitcoins-troubles-go-far-beyond-elon-musk">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Liberal Zionist’s Move to the Left on the Israeli-Palestinian Conflict</strong> - Peter Beinart, once a staunch defender of Israel, is arguing for the Palestinians’ right to return. - <a href="https://www.newyorker.com/news/annals-of-populism/a-liberal-zionists-move-to-the-left-on-the-israeli-palestinian-conflict">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The influencers are burned out, too</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/dk-RlHar5c-fuDUjjGXao2x-TAI=/61x0:904x632/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69338543/Screen_Shot_2021_05_24_at_5.05.22_PM.0.png"/>
<figcaption>
The Clubhouse’s Instagram page. | Instagram
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The particular ennui of being a social media star is a microcosm of what’s happening to us all.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DoVQUw">
Earlier this month, the writer and English professor Barrett Swanson published a story in Harper’s about his <a href="https://harpers.org/archive/2021/06/tiktok-house-collab-house-the-anxiety-of-influencers/">five days at Clubhouse</a>, the collective of dozens of college-aged social media hopefuls living in a smattering of content mansions in Los Angeles. He emerged with the sneaking suspicion that maybe all of this is bad, not only for the world but for the influencers themselves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FRfEn6">
“For a moment, I cannot remember who I am or why I am sitting here amid this sea of beautiful young people, all of them desperate for recognition, their whole lives ahead of them, empty at the absolute center,” he writes in the closing paragraph. “TikTok is a sign of the future, which already feels like a thing of the past. It is the clock counting down our fifteen seconds of fame, the sound the world makes as time is running out.”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f216ph">
It’s easily the best and most depressing piece of journalism about famous TikTokers I’ve ever read, a “Slouching Towards Bethlehem” for influencers. Here are some things Swanson witnesses on his visit: a 19-year-old who just made $60,000 by filming a <em>Lady and the Tramp</em>-style kiss with his girlfriend as sponcon for a chicken-fingers joint; a list of video ideas which includes “pranks” and “tuxedos”; a kid who, out of nowhere, claimed that “Hitler invented sex dolls” based on a TikTok he just watched; an influencer manager who appears to be in the thrall of QAnon; pervasive neglect for the influencers on the part of their managers; and repeated offers to help Swanson become a TikTok influencer himself, as though the only reason for visiting at all was, of course, to take a little piece of their celebrity for his own.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pmOsN3">
Mostly, though, he sees the extreme precarity that courses through every person, every thought, every action that occurs in the house. “Several times throughout my trip, I think I can see the toll this takes on them, a kind of pallid desperation that flickers across their faces,” he writes. “At one point, Brandon [one of the influencers] comes over and says, ‘The scary thing is you never know how long this is going to last, and I think that’s what eats a lot of us at night. It’s like, What’s next? How long can we entertain everyone for? How long before no one cares, and what if your life was worth nothing?’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vyo8AQ">
It’s a topic I’ve discussed with almost every big TikToker I’ve interviewed, the question of what happens if and when it goes away. It’s a tough question to ask, but I’m always struck by the thoughtfulness of their answers: Whether they have 100,000 followers or a few million, all the TikTokers know that their fame will likely fade unless they work very, very hard to cultivate themselves into something solidly monetizable. They seamlessly toggle between their two identities — the real person and the online persona — and speak with a kind of cynicism about tying their livelihoods to a platform that could disappear in an instant. It all feels like stuff they shouldn’t have to think about, not yet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D0Ahqu">
What the piece doesn’t include are the other things that come with being a famous TikToker. Namely, that operations such as Clubhouse are often run by people who either have no clue what they’re doing thanks to the extremely low barrier to entry into such a field, or are actively harming the influencers they claim to help.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="roxagD">
Clubhouse’s founder, <a href="https://www.businessinsider.com/influencers-describe-problems-at-clubhouse-media-group-content-mansions-2021-4">Amir Ben-Yohanan, has been accused</a> of bullying, sexism, and creating volatile atmospheres. Chase Zwernemann, the manager in Swanson’s story who shows him a QAnon video, has <a href="https://www.vox.com/the-goods/21459677/tiktok-house-la-hype-sway-girls-in-the-valley">allegedly scammed other TikTokers</a> at a previous content house. Many TikTokers are taken in by sketchy managers who sign them to predatory contracts because of the nature of how TikTok fame operates: When you get famous overnight, you’re not given time to learn the ropes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fRBazy">
And that’s only if you become famous enough to get lucrative brand deals. For the majority of kids who go viral on TikTok, the attention doesn’t last. “I wish I never got this sort of fame,” a 16-year-old former <a href="https://www.vox.com/the-goods/2020/2/27/21153364/tiktok-famous-backlash">TikToker named Sam told me last year</a>. He’d been creating delightfully bizarre videos that earned him a following of nearly 200,000, until suddenly the view counts started to drop and it felt like the audience didn’t like him anymore. He left the platform and sought therapy for the anxiety he’d developed due to TikTok.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TUJegA">
Lots of TikTokers bring this up. They’re afraid of branching out from whatever the algorithm decides it likes for fear of becoming a has-been, and they’re burned out by the churn of endlessly creating content they barely even like. Some have public meltdowns, others quit for good, while even the app’s biggest star Charli D’Amelio said she often feels <a href="https://www.dexerto.com/entertainment/charli-damelio-admits-difficult-to-enjoy-tiktok-fame-with-constant-hate-1569713/">overwhelmed by the constant negative attention</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BNWD6A">
A few days ago, the 19-year-old TikToker Spencewuah tearfully announced he was taking a break from TikTok after backlash from a perceived gaffe. He has more than 9 million followers, but as Kate Lindsay <a href="https://embedded.substack.com/p/the-crushing-isolation-of-tiktok?token=eyJ1c2VyX2lkIjo4Nzc4ODcsInBvc3RfaWQiOjM2Nzg1OTg3LCJfIjoibTJOV0oiLCJpYXQiOjE2MjE4NzQ0ODEsImV4cCI6MTYyMTg3ODA4MSwiaXNzIjoicHViLTMxMjA4OCIsInN1YiI6InBvc3QtcmVhY3Rpb24ifQ.gXwdpZtt0RB_Y5Kt0U6lZcNpbQw6muvkk3cs_orWXG0">pointed out on her Substack Embedded</a>, that doesn’t change the fact that he’s navigating fame alone. “Tons of midsize creators burn out or take breaks or disappear completely because they’re popular enough to amass giant followings but not to earn the kind of money it takes to insulate themselves from those followings. TikTok, of course, relies on these midsize creators,” she wrote. Yet besides making them famous, TikTok the company doesn’t seem to do much to help them with its consequences.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S3hz7G">
What’s happening to influencers is a microcosm of what’s happening to everyone. At Clubhouse, Swanson connects the stars to his own university students, kids who write increasingly about their anxiety, depression, and suicidal ideation, kids who appear in his office “sad in a way they cannot explain, desperate for something they don’t know how to have.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EHvNIs">
Several of them, he says, dropped out to move to LA to chase the influencer dream for themselves, hoping to become famous in the same way all the other kids got famous: By getting their face to appear on millions of other people’s screens. Left unsaid is what happens when they do win the TikTok lottery, and how the unexplainable sadness doesn’t really go away.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jvoCCM">
We’re seeing this in workplaces, too, most visibly in media. Journalists are <a href="https://www.nytimes.com/2020/09/23/business/media/substack-newsletters-journalists.html">leaving staff positions to start their own Substacks or Patreons</a>, hoping to cash in their followings on the creator economy, the professional adult version of dropping out of college and moving to LA. Low-wage workers, disillusioned by the failures of bosses and owners to treat them fairly, aren’t returning to traditional jobs, and many are surely turning to the gig or creator economies. The influencer industry is simply the logical endpoint of American individualism, which leaves all of us jostling for identity and attention but never getting enough.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vGOrAj">
What these anxious influencers need is help, help from people who are not also trying to squeeze every last dollar out of them. Lindsay proposed that TikTok and other social media platforms provide therapy for struggling creators, which seems like a viable and promising possibility, however dystopian the idea of a company creating so many mental health problems that they then must directly fix them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9rUjUU">
They need community, and not the kind of faux community promised by toxic content houses or publicity-designed friendships. They need meaning beyond the numbers on the screen, and they need to find ways to make content that is meaningful to them outside of the <a href="https://www.vox.com/the-goods/2021/5/18/22440937/tiktok-addison-rae-bella-poarch-build-a-bitch-charli-damelio-mediocrity">oppressive blandness that the algorithm rewards</a>. These are things we all aren’t getting in our current social and economic systems. Influencers, who for better or for worse are increasingly society’s role models, are only the most public examples.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sxXgyz">
<em>This column first published in The Goods newsletter. </em><a href="https://www.vox.com/pages/newsletters"><em>Sign up here</em></a><em> so you don’t miss the next one, plus get newsletter exclusives.</em>
</p></li>
<li><strong>Any bipartisan January 6 commission is probably doomed</strong> -
<figure>
<img alt="Senate Minority Leader Mitch McConnell (R-KY) makes his way to a Senate Republican Policy luncheon at the U.S. Capitol on May 18, 2021 in Washington, DC." src="https://cdn.vox-cdn.com/thumbor/oqNnADNeuMNDiP5Tkz-Ylpx6Y_Q=/83x0:6035x4464/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69338432/GettyImages_1318706653.0.jpg"/>
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Senate Minority Leader Mitch McConnell at the US Capitol on May 18. | Kevin Dietsch/Getty Images
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Even if it could pass, McConnell and McCarthy likely won’t appoint commissioners who would work in good faith.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2t5VqW">
Days after the chaotic storming of the Capitol on January 6, some Republican members of Congress had an idea.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zo7isN">
What the country needed, Reps. John Katko (R-NY), Rodney Davis (R-IL), and others decided, was a bipartisan commission, akin to <a href="https://9-11commission.gov/report/">the one established after 9/11</a>, to sort through the facts and determine just how such a terrible breach of government security happened.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SdYpLs">
Now, though, the chances for such a commission are imperiled. A bill to establish it passed the House last Wednesday with support from every Democrat and 35 Republicans. But most others in the GOP, including party leaders, have come out strongly against the bill, with the party’s senators <a href="https://www.politico.com/news/2021/05/21/filibuster-gop-opposition-commission-489954">planning a filibuster</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Cm2Fw">
Republicans have evidently calculated that such a commission’s findings would likely hurt their party’s electoral prospects. Some even admit this: “Anything that gets us rehashing the 2020 election, I think, is a day lost on being able to draw contrast between us and the Democrats’ very radical left-wing agenda,” Senate Minority Whip John Thune <a href="https://www.washingtonpost.com/politics/mcconnell-comes-out-against-jan-6-commission-imperiling-its-chances-of-becoming-law/2021/05/19/60de1f52-b8b3-11eb-a5fe-bb49dc89a248_story.html">told reporters last week</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ApulJF">
But even if a deal does somehow come together, there are real reasons to doubt whether such a commission would achieve anything substantial.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bTfY5k">
There’s nothing magical about this proposed bipartisan commission — it would have the same formal powers as any ordinary congressional committee looking into the matter. In fact, its requirement for bipartisan support to issue subpoenas means it could well be less aggressive at unearthing new information than, say, a Democratic-only House committee investigation could be.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iWPGY5">
Its hoped-for advantage would instead be in the realm of messaging. The idea is that if such a body is deemed above politics, it could deliver an assessment of what happened that would be viewed as credible by both sides, shaping a national narrative.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Uett8X">
This second aim is what supporters of a January 6 commission are really hoping to achieve. The hope is that, if the reasonable Republicans and Democrats could only get together, they could reach consensus and sagely explain how and why the Capitol was stormed, and how the US can stop something like it from happening again.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A7TnQn">
It’s a doomed hope.
</p>
<h3 id="juqhbz">
How the 9/11 commission “succeeded,” and why a 1/6 commission probably wouldn’t
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IsrzLr">
The bill passed by the House is deliberately modeled after the 9/11 commission — it calls for 10 commissioners, five from each party, who would be appointed by congressional leaders. So that earlier body is a useful comparison, with lessons for how such commissions can come to be deemed successful, and what they actually achieve.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0pHENV">
The first lesson is about PR. The 9/11 Commission Report was published as a 567-page book which <a href="https://www.bookweb.org/news/success-911-commission-report-surprises">became a best-seller</a>, and in the discourse, it was often treated as the definitive assessment on what had gone wrong. But this was not really because the commission discovered a ton of new information (a joint congressional committee <a href="https://www.justsecurity.org/76216/interview-with-phil-shenon-lessons-from-the-uncensored-history-of-the-9-11-commission/">had already finished a report</a> with largely similar facts), or because everything went smoothly (there were <a href="https://www.nytimes.com/2006/08/20/books/review/20Bamford.html">many politicized disputes</a> and much important information <a href="https://www.washingtonpost.com/history/2021/02/17/9-11-commission-capitol-attack-investigation/">was withheld</a>).
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5U8YKE">
One reason is that, as Philip Shenon (author of a book on the commission) recently argued in an <a href="https://www.justsecurity.org/76216/interview-with-phil-shenon-lessons-from-the-uncensored-history-of-the-9-11-commission/">interview with Just Security</a>, the report was “packaged” better — many remarked that it read <a href="https://www.cambridge.org/core/journals/journal-of-american-studies/article/abs/it-reads-like-a-novel-the-911-commission-report-and-the-american-reading-public/19DD84FE2A660E55FE9A7FBEE6A473B2">more like a novel</a> than a policy document. Additionally, the two savvy moderate retired politicians in charge, former New Jersey Gov. Tom Kean, a Republican, and former Indiana Rep. Lee Hamilton, a Democrat, effectively became joined at the hip to tout the final product as truly bipartisan and credible.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3VQe6V">
But what’s crucial here is that, in the end, Kean and Hamilton <em>wanted</em> to tout a bipartisan product. This time around, from the start, Republicans oppose the very idea of the commission. Their appointees will be hand-picked by McConnell and House Minority Leader Kevin McCarthy, who are more likely to choose commissioners prone to obstruct and object, not to lend the eventual report a bipartisan halo.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HwzK2U">
The second lesson is about politics. The sunny view of bipartisan commissions is that members of both parties boldly manage to put politics aside and do the right thing for the country. The more cynical and probably more realistic way to look at them is that politics never truly leaves the process — especially when the issue has serious electoral implications for both parties.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yK2xZU">
The question of who in the US government deserved blame for the September 11, 2001 attacks had potentially monumental implications for both parties. Republicans had blamed Bill Clinton for failing to act against Osama bin Laden while he was president in the late 1990s, while Democrats had blamed George W. Bush for ignoring warnings in the advance of the attacks themselves. The report was crafted as Bush’s reelection was looming, and with widespread speculation that Hillary Clinton would run for president one day.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yG6QjO">
The 9/11 commissioners achieved bipartisan unanimity despite all this. But they did so essentially by ensuring the final report would be “<a href="https://www.wsj.com/articles/SB108005311070962877">balanced</a>,” and wouldn’t single out either president for overmuch blame. Critics from either side would argue that the desire for bipartisanship resulted in something like a whitewash.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WdKtxL">
The storming of the Capitol is an issue with very different partisan dynamics, and it’s difficult to imagine what a “balanced” report on it could look like. Any broad and serious assessment of what happened only has a realistic chance of making one party — the party of Donald Trump — look bad. And Republicans have been very clear that, for electoral reasons, they don’t want to do this.
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<h3 id="CcLNqr">
In practice, the commission would spotlight an issue that divides the GOP
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Dn3r65">
Even though Republicans would likely be able to prevent a bipartisan 1/6 commission from achieving much of substance, they’d really prefer not to have one at all.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5V1ybt">
That’s because, as Thune admitted above and as <a href="https://www.vox.com/2021/5/5/22419504/liz-cheney-trump-big-lie">Liz Cheney’s ouster</a> shows, party strategists view <em>any</em> discussion of Trump’s attempt to overturn the election result as a harmful issue for their party at this point. They want to make the 2022 elections about Biden and Democrats, not Trump.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TL1YVI">
Parties prefer issues that unite their own members and put their opponents on the defensive. But on this topic, it’s clearly Republicans who are on the defensive. The GOP base <a href="https://cdn.cnn.com/cnn/2021/images/04/30/rel3e.-.voting.and.elections.pdf">is out of step with public opinion</a> on this issue. So they’d really like it to just go away.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FzrLTn">
Democrats, meanwhile, have electoral incentives to try and keep the storming of the Capitol in the news however they can. “Democrats should spend every day tying all of it to the Republican Party,” political consultant James Carville <a href="https://www.vox.com/22338417/james-carville-democratic-party-biden-100-days">recently told</a> my colleague Sean Illing. (McConnell <a href="https://twitter.com/lacaldwelldc/status/1395191685253144577?s=21">has reportedly been sharing</a> that interview to argue that Democrats are motivated by politics here.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Rb2pmZ">
So if electoral and messaging advantage is the true goal, the commission would still be worthwhile for Democrats. But feel-good bipartisanship isn’t in the cards, and fact-finding would probably be difficult too if the Republican commissioners agree to vote as a bloc against any controversial subpoenas.
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<h3 id="G7StVU">
Do Democrats have fallback options if the bill doesn’t pass?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JXdDHi">
In any event, theories of how such a commission would play out are probably moot, unless there’s a surprising sudden shift in Senate Republicans’ thinking.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zirgx9">
Currently, there are a few Senate Republicans, like Susan Collins (R-ME) and Mitt Romney (R-UT), who <a href="https://www.politico.com/news/2021/05/21/filibuster-gop-opposition-commission-489954">sound open</a> to supporting a changed version of the bill (Collins wants the staff to be bipartisan, and Romney wants to ensure that they’ll finish by their end-of-year deadline). Many others, though, are dug in firmly against the idea and seem immovable. So the current betting is that the 10 GOP votes needed to overcome a filibuster will not materialize.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8PWQ6Z">
What, then, can Democrats do instead?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NTRWby">
It’s useful again to remember the two main things such a commission can do — fact-finding and narrative-shaping.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DBfWBl">
As far as formal fact-finding powers go, a congressional committee can do everything a bipartisan commission can do; namely, it can hold hearings and issue subpoenas. One advantage the commission might have is unified focus on one topic — but that could also be achieved by establishing a special “select committee” to investigate January 6, as House Republicans did for Benghazi.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Cpkz7Q">
In the House, Democrats have majorities on every committee, so they can issue whatever subpoenas they want. The story is more complicated in the Senate, where committees are evenly divided due to the chamber’s 50-50 split. According to an <a href="https://www.insidepoliticallaw.com/2021/02/19/senate-subpoena-power-under-the-2021-power-sharing-agreement/">analysis from the law firm Covington &amp; Burling LLP</a>, the only senator who can unilaterally issue a subpoena without Republican support is Jon Ossoff (D-GA), who chairs an investigations subcommittee. It’s not entirely clear whether committees could potentially elevate blocked subpoenas to a full Senate vote, but it may be possible.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Uw0LbN">
Still, as <a href="https://www.aei.org/profile/norman-j-ornstein/">Norm Ornstein</a>, at the conservative American Enterprise Institute think tank, <a href="https://www.washingtonpost.com/opinions/2021/05/19/other-options-jan-6-commission-ornstein/">recently pointed out</a> in an interview with the Washington Post’s Greg Sargent, while “congressional subpoena power is theoretically extraordinarily powerful,” it’s clear that “practically it can be subverted fairly easily.” Ornstein added: “We’ve seen instance after instance of people defying subpoenas, taking it to court, and stretching it out for years.” In practice, as we saw with various hearings during the Trump years, congressional committees are most successful with willing witnesses who want to hand over documents or testify (often technically under subpoena for legal cover).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ww2nzn">
And when it comes to shaping the narrative, it does seem that congressional committees would, more likely, be deemed partisan by the media, as compared to a special bipartisan commission. But the hope to establish one consensus national narrative around the events of January 6 was always a pipe dream.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Rhb4AX">
Most Republican voters now inhabit an information environment dominated by conservative media outlets like Fox and social media similarly designed to tell them what they want to hear. Acknowledging that reality, the most Democrats may be able to do is push on forward, trying to gather facts and make a public case to their best of their ability — on their own.
</p></li>
<li><strong>The lingering threat of fall Covid-19 outbreaks</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/C-3r1a1jLgGv7qXIfGQk1CECLnU=/0x0:5460x4095/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69338299/1229490456.0.jpg"/>
<figcaption>
A discarded face mask and fallen autumn leaves in Berlin on November 6, 2020. | David Gannon/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The vaccines are holding Covid-19 down in the US for now, but it could come back this fall.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W4tBji">
You’ve heard it before, but it’s true: This summer in America is going to be so good. After a year of Covid-19-induced fear, the US vaccination campaign and warmer weather will give the country a much-needed reprieve from the coronavirus and all the horrors it brought.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zj3kMk">
But what comes after the summer?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eVYtGE">
Last year, we saw that the coronavirus spreads more easily in the fall and winter than it does in warmer months. <a href="https://ourworldindata.org/explorers/coronavirus-data-explorer?zoomToSelection=true&amp;time=2019-12-31..latest&amp;pickerSort=asc&amp;pickerMetric=location&amp;Metric=Confirmed+deaths&amp;Interval=Cumulative&amp;Relative+to+Population=false&amp;Align+outbreaks=false&amp;country=USA~EuropeanUnion">More than 330,000 Americans</a> died from Covid-19 over six months during the fall and winter — an unimaginable death toll, amounting to nearly nine times <a href="https://www.cdc.gov/nchs/fastats/accidental-injury.htm">all car crash deaths in 2019</a> and more than 17 times <a href="https://www.cdc.gov/nchs/fastats/homicide.htm">all murders</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9wvTti">
One cause was the country’s relaxed response to the coronavirus, as much of America dropped its guard and precautions. But experts also blame the seasonality of Covid-19, as falling temperatures pushed people indoors, where the virus has an easier time spreading, and families gathered for the holiday season.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JkuYA7">
America is in a much better place than it was last fall and winter. A combination of the vaccines and natural immunity from past Covid-19 infections is suppressing the virus. But the country isn’t totally in the clear yet: The majority of the US population <a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations">still isn’t vaccinated</a>, and the rate of daily vaccinations has dramatically slowed, <a href="https://ourworldindata.org/explorers/coronavirus-data-explorer?zoomToSelection=true&amp;time=2020-12-20..latest&amp;pickerSort=desc&amp;pickerMetric=total_vaccinations_per_hundred&amp;Metric=Vaccine+doses&amp;Interval=7-day+rolling+average&amp;Relative+to+Population=false&amp;Align+outbreaks=false&amp;country=~USA">now standing at about half</a> of what it was at its peak in mid-April.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A76wgL">
Then there are the coronavirus variants. The vaccines do a good job overpowering the known variants, <a href="https://www.vox.com/22385588/covid-19-vaccine-variant-mutation-n440k-india-moderna-pfizer-b1617">based on the research</a>, but at least some variants do seem to overcome some natural immunity. So people in the US who are unvaccinated but have had Covid-19 before might still be vulnerable. Some experts also worry that natural immunity from a previous infection might not be durable — perhaps fading over time, potentially in time for a fall wave. (There are similar concerns about the vaccines, but vaccine-induced immunity so far has proven to be better than natural immunity in research trials.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="j0bP7X">
There’s a risk, too, that the warmer weather and potential seasonality of the virus will in some sense give the country a false sense of security. By letting much of the US (<a href="https://www.vox.com/22442307/covid-19-vaccine-south-sun-belt-coronavirus-cases-pandemic-summer">though not all</a>) safely socialize outside, while Covid-19 cases and deaths continue to decline, there’s a risk that people will move on from the virus too quickly — and the remaining unvaccinated will come to believe, if they don’t already, that they don’t really need to get the shot.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4ZWZVJ">
All of these factors — the holidays, colder weather, variants, and at least some immunity potentially dropping off — could combine to create a Covid-19 comeback this fall and winter. The experts I’ve talked to don’t believe this will be a huge, nationwide surge — too many will be vaccinated by the fall for that to happen. But particularly in parts of the country with low vaccination rates, there could be local or state-level spikes of the coronavirus.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kQeCKG">
“It could happen — if we really stall in our vaccination coverage,” Jen Kates, director of global health and HIV policy at the Kaiser Family Foundation, told me. “If we increase our vaccination coverage, I’m less worried about that.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UdwFlK">
This isn’t a reason to despair. Especially if you’re vaccinated, <a href="https://www.vox.com/22423098/covid-19-vaccine-coronavirus-protection-herd-immunity">you’re extremely safe from Covid-19</a>. Rather, this is a call for more people to get vaccinated — it’s the one way the country can guarantee another fall or winter surge never comes.
</p>
<div class="c-float-right">
<div id="izKxXc">
<div>
</div>
</div>
</div>
<h3 id="dm1IRw">
We’re still not done with the pandemic
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2ERqp6">
The news on Covid-19 in the US is genuinely incredible right now. Almost half the country <a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations">has had at least one vaccine dose</a>. Daily new coronavirus cases are <a href="https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases">less than a 10th</a> of what they were during a January peak, and deaths are <a href="https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases">down more than 85 percent</a> from January as well. The higher vaccination rates, decline in cases and deaths, and warmer weather will soon, if they haven’t already, let us safely engage in the kinds of social interactions that were dangerous just a year ago.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WBqwiO">
This is all genuinely fantastic, thrilling news. Personally, I’m planning trips and vacations that I would have been too scared to do a year ago. I no longer wear a mask unless it’s required by law or by the businesses I’m patronizing. I’ll very soon see friends and family that I haven’t seen in a long time. As someone who’s vaccinated, I just don’t worry about my own risk of Covid-19 at all anymore — and many experts <a href="https://www.vox.com/22423098/covid-19-vaccine-coronavirus-protection-herd-immunity">share that view as well</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="14K6N5">
But this optimism can be taken a bit too far. As much as things have improved, they’re not completely back to normal yet. Covid-19 cases and deaths <a href="https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases">are still near or above levels</a> that were considered fairly high last summer. More than 60 percent of the country <a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations">still isn’t fully vaccinated</a>, and more than half <a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations">haven’t gotten at least one shot</a>. In <a href="https://www.nytimes.com/interactive/2020/us/covid-19-vaccine-doses.html">some states</a>, rates of vaccination are even lower — with two-thirds of the population not getting one shot yet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0YcUin">
“It’s good to celebrate at this stage,” Mauricio Santillana, a researcher at Harvard Medical School and Boston Children’s Hospital, told me. “But we cannot be fully confident that this is the end of it.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XSlEgX">
That large unvaccinated population means a lot of people remain vulnerable to the virus. We don’t know what level of vaccination is needed for herd immunity (the level of immunity that ensures infections won’t spread within a community), but experts <a href="https://www.vox.com/22400322/vaccines-herd-immunity-coronavirus-israel">believe</a> it will require at least 60 percent of the population vaccinated and perhaps as high as 85 or 90 percent, depending in part on the variants we’re dealing with.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FZGydh">
The remaining vulnerabilities could grow, too. Natural immunity could fade over time, or more infectious variants could pop up. As fall arrives and the weather cools, people will shift activities back to poorly ventilated indoor environments where airborne viruses can more easily spread. People could drop their guard too much, especially if Covid-19 cases continue to decline over the summer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PwHVtl">
“I do think in the fall and winter, things will be much better,” Ashish Jha, dean of the Brown University School of Public Health, told me. “But we may very well see a bump, and we may need to put in some mild public health restrictions for short periods of time if we see surges in cases.” He added, “We have to be ready.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cyPXWZ">
Imagine a potential scenario: Cases and deaths continue to drop. The summer brings a renewal of social activities. Covid-19 starts to look like a thing of the past. Covid-related precautions, legal and voluntary, are widely discarded. In this environment, people who have yet to get the vaccine decide maybe they don’t need to — after all, the virus isn’t really a present threat anymore. So cases and deaths drop, but so do vaccination rates.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m3c2QE">
Then the fall comes. More people move indoors, travel, and gather for the holidays. Maybe a new variant becomes the dominant form of the virus in the US. At the same time, perhaps natural immunity is weakened. In a few parts of the country, such as the <a href="https://covid.cdc.gov/covid-data-tracker/#vaccinations">South and Midwest</a>, a lot of the population remains unvaccinated. Suddenly, the virus starts to pick up locally, or maybe even beyond that, especially if vaccination rates are low statewide. Local and state governments may be slow to react, resistant to reinstituting restrictions they had only recently celebrated the end of.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZDoqQa">
This scenario isn’t guaranteed. Maybe the vaccines are so great that it turns out America’s current vaccination rates, along with natural immunity that perhaps turns out more durable than previously thought, is enough to keep the coronavirus at bay.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2obmYZ">
But it’s a risk. And it’s an unnecessary one given that there is a good way to avoid it.
</p>
<h3 id="YsAvA9">
There’s a solution: Vaccinate more people
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OqgwAb">
The vaccines are great. <a href="https://www.vox.com/22423098/covid-19-vaccine-coronavirus-protection-herd-immunity">Evidence</a> from clinical trials and the real world has found that they nearly eliminate the risk of serious illness, hospitalization, and death from Covid-19. In Israel, which has the world’s most advanced vaccination campaign, a vaccination rate of 60 percent <a href="https://www.vox.com/22400322/vaccines-herd-immunity-coronavirus-israel">has let</a> the country remain nearly fully open <em>and</em> see daily Covid-19 deaths fall to the single digits or zero — a big improvement for a country that experienced some of the worst coronavirus surges in the world.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JGnAob">
But the vaccines can only do their thing if more people get vaccinated. America is not at Israel’s 60 percent rate. And there’s a good chance the US will have to go higher than that — given that Israel’s reopening still involves mask mandates and <a href="https://www.vox.com/22434875/covid-19-vaccine-passports-mask-mandate-cdc-freedom">vaccine passports</a>, both of which Americans are increasingly rejecting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eKFmzX">
As long as there are “pockets of people who choose not to vaccinate, you leave the door open for Covid to come back,” Santillana said. “We need to stay vigilant.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="knKiqi">
For lawmakers and other leaders, that means doing more work to get people vaccinated. Experts <a href="https://www.vox.com/2021/5/5/22419281/covid-19-vaccines-herd-immunity-hesitancy-anti-vaxxers">have called for</a> a three-tiered approach: improving access, providing incentives, and imposing some mandates if necessary. That could mean, at the state level, partnering with entertainment and transportation venues to offer shots on-site, providing financial or other material rewards to the vaccinated, and pushing schools, including colleges, to require vaccinations. It could also mean, on the private side, employers offering vaccines on-site, handing out pay bonuses to the vaccinated, and making vaccination required to come back to the office.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UOufxw">
For the public, that means more people choosing to get vaccinated. One thing that could help here is vaccinated people sharing their stories, given that <a href="https://www.kff.org/coronavirus-covid-19/poll-finding/kff-covid-19-vaccine-monitor-april-2021/">almost one in five people</a> is in wait-and-see mode with the vaccines, largely standing by until the people around them get the shot.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QOReUw">
America just got through a pandemic year with so much uncertainty. It has a chance to stamp out one of the last bits of uncertainty — and the risk of another fall and winter surge — if as many people as possible get vaccinated. But it’s on everyone to make that happen.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indian men and women’s squads begin hard quarantine ahead of England tour</strong> - The Indian women’s team members also entered their eight-day hard quarantine at the Grand Hyatt in Mumbai located near the international airport.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Govt. to open 143 Khelo India centres across 7 states</strong> - These centres will be set up in Maharashtra, Mizoram, Goa, Karnataka, Madhya Pradesh, Arunachal Pradesh and Manipur</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Naseem Shah expelled from Pakistan Super League for violating COVID-19 protocols</strong> - The 18-year-old fast bowler reportedly had an outdated COVID-19 negative certificate with him.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>England vs India series itinerary unlikely to change after ECB-BCCI back-channel talks</strong> - It is learnt that the informal discussions between the bigwigs of both boards have not yielded any favourable result.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phil Mickelson — fabulous at fifty</strong> - Defies age to win PGA Championship, the oldest to win a Major</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lakshadweep administrator pursuing imperialist-corporate agenda, says Mohammed Faizal</strong> - The NCP member of Lok Sabha from the Lakshadweep group of islands, said that the administrator was acting in a way that disturbed the people</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBI chief selection: In dissent note, Adhir Ranjan questions conduct of DoPT</strong> - Congress leader asked for deferment of meeting of High Powered Committee</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Care centres for migrant labourers to come up</strong> - As part of COVID-19 containment measures, various local bodies in the district will arrange domiciliary care centres for migrant labourers. The centre</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cyclone Yaas | Odisha shifts over 2 lakh people to cyclone shelters by 4 p.m.</strong> - Dry foods have been pre-positioned in shelters and three government officers would remain in charge of each shelter.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I urge PM Modi to take initiative for dialogue with Chief Ministers: Anand Sharma</strong> - Addressing the COVID-19 surge in the country, the Congress leader said it is time for Modi to walk the talk on cooperative federalism</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>EU agrees new Belarus sanctions after plane arrest</strong> - Belarusian airlines will be banned from EU skies after a flight was diverted and a journalist held.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Belarus plane: What action has the EU taken?</strong> - What sanctions are in place against Belarus and what new measures are being considered?</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Belarus Ryanair flight diverted: Passengers describe panic on board</strong> - The plane changed course as it neared its destination leaving passengers shocked and confused.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rocco Morabito: Italian fugitive arrested in Brazil</strong> - Rocco Morabito, who has been wanted since the 1990s, escaped from a prison in Uruguay in 2019.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Damiano David: Eurovision winner cleared of drug use by broadcaster</strong> - A test clears Måneskin’s lead singer of drug use during the competition’s grand final.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>It’s ransomware, or maybe a disk wiper, and it’s striking targets in Israel</strong> - Dubbed Apostle, never-before-seen wiper masquerades as ransomware. - <a href="https://arstechnica.com/?p=1767365">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bernie Sanders wants to stop NASA funding for Blue Origin</strong> - The Endless Frontier Act? More like the Endless Amendment Act. - <a href="https://arstechnica.com/?p=1767287">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Freenode IRC staff resign en masse after takeover by Korea’s crown prince</strong> - Former staffer alleges “a hostile entity is now in control… and has your data.” - <a href="https://arstechnica.com/?p=1767203">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Actively exploited macOS 0-day let hackers take screenshots of infected Macs</strong> - Apple patches vulnerability that malware used to bypass macOS privacy protections. - <a href="https://arstechnica.com/?p=1767247">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>For research citations, no replication is no problem</strong> - Looking back at big replication projects, finding they don’t seem to have mattered. - <a href="https://arstechnica.com/?p=1767246">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A bus full of ugly people had a head on collision with a truck. When they died, God granted all of them one wish. The first person said, "I want to be gorgeous.</strong> - <!-- SC_OFF -->
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God snapped his fingers and it happened. The second person said the same thing and God did the same thing. This want on and on throughout the group. God noticed the last man in line was laughing hysterically. By the time God got to the last ten people, the last man was laughing and rolling on the ground. When the man’s turn came, he laughed and said, “I wish they were all ugly again.”
</p>
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/nikan69"> /u/nikan69 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/nke64o/a_bus_full_of_ugly_people_had_a_head_on_collision/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/nke64o/a_bus_full_of_ugly_people_had_a_head_on_collision/">[comments]</a></span></p></li>
<li><strong>Just watched an interesting documentary on cocaine…</strong> - <!-- SC_OFF -->
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Going to watch all documentaries this way now!
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/oblectoergosum"> /u/oblectoergosum </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/nkfmp1/just_watched_an_interesting_documentary_on_cocaine/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/nkfmp1/just_watched_an_interesting_documentary_on_cocaine/">[comments]</a></span></p></li>
<li><strong>Fred came home from University in tears. “Mum, am I adopted?”</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“No of course not”, replied his mother. Why would you think such a thing?
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Fred showed her his genealogy DNA test results. No match for any of his relatives, and strong matches for a family who lived the other side of the city.
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Perturbed, his mother called her husband. “Honey, Fred has done a DNA test, and… and… I don’t know how to say this… he may not be our son.”
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“Well, obviously!” he replied.
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“What do you mean?”
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“It was your idea in the first place” her husband continued. “You remember, that first night in hospital when the baby did nothing but scream and cry and scream and cry. On and on. And you asked me to change him.”
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“I picked a good one I reckon. Ever so proud of Fred.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/whyamihere999"> /u/whyamihere999 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/njytcl/fred_came_home_from_university_in_tears_mum_am_i/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/njytcl/fred_came_home_from_university_in_tears_mum_am_i/">[comments]</a></span></p></li>
<li><strong>There is only one thing that beats a beautiful girl with amazing voice.</strong> - <!-- SC_OFF -->
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And that’s Chris Brown
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/sambhav25"> /u/sambhav25 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/nk017o/there_is_only_one_thing_that_beats_a_beautiful/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/nk017o/there_is_only_one_thing_that_beats_a_beautiful/">[comments]</a></span></p></li>
<li><strong>A shark is teaching his kid how to eat humans</strong> - <!-- SC_OFF -->
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and he says “look son, first you swim full force at the human but at the last second, you turn away. Then you swim at him full force again, but again at the last second you swim away. Then you can go back and eat the human.”
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The son looks confused and asks, “But dad, why can’t we just go eat the human the first time?”
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Dad replies “Well, you can but why would you want to eat him when he’s still full of shit?”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/sakatimi"> /u/sakatimi </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/nkmuuw/a_shark_is_teaching_his_kid_how_to_eat_humans/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/nkmuuw/a_shark_is_teaching_his_kid_how_to_eat_humans/">[comments]</a></span></p></li>
</ul>
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