diff --git a/archive-covid-19/25 May, 2021.html b/archive-covid-19/25 May, 2021.html new file mode 100644 index 0000000..6a1c8fe --- /dev/null +++ b/archive-covid-19/25 May, 2021.html @@ -0,0 +1,193 @@ + +
+ + + ++Objectives To describe perceived changes in sexual behaviours, including virtual sex (sexting and cybersex), and access to HIV/STI testing and care during COVID-19 measures in Panama. Methods We conducted an online cross-sectional survey from August 8 to September 12, 2020, among adults (≥18 years) residing in Panama. Participants were recruited through social media. Questions included demographics, access to HIV/STI testing and HIV care and sexual behaviours three months before COVID-19 social distancing measures and during social distancing measures (COVID-19 measures). Logistic regression was used to identify associations between variables and behavioural changes. Results We recruited 960 participants; 526 (54.8%) identified as cis-women, 366 (38.1%) cis-men, and 68 (7.1%) non-binary or another gender; median age was 28y (IQR:23-37y), 531/957 (55.5%) were of mixed-ethnicity (mixed-Indigenous/European/Afro-descendant ancestry). Before COVID-19 measures, virtual sex was reported by 38.5% (181/470) cis-women, 58.4% (184/315) cis-men and 45.0% (27/60) non-binary participants; during COVID-19 measures, virtual sex increased among 17.2% cis-women, 24.7% cis-men and 8.9% non-binary participants. During COVID-19 measures, 230/800 [28.8%] of participants reported decreased casual sex compared to pre-COVID-19 measures. Compared to pre-COVID-19 measures, decreased casual sex were reported more frequently during COVID-19 measures by cis-men compared to cis-women (39.2% versus 22.9%, urban/rural adjusted odds ratio [AOR]=2.17, 95% confidence interval [CI]:1.57-3.01); and by Afro-descendant compared to mixed-ethnicity participants (40.0% versus 29.8%, AOR=1.78, 95%CI:1.07-2.94). Compared to no change in virtual sex (16.8%), increase in virtual sex (38.5%, AOR=1.78, 95%CI:1.10-2.88); and decreased virtual sex (86.7%, AOR=16.53, 95%CI:7.74-35.27) were associated with decreased casual sex encounters. During COVID-19 measures, HIV/STI testing could not be obtained by 58.0%(58/100) participants who needed a test, and interrupted HIV care was reported by 53.3% (8/15) HIV-positive participants. Conclusions COVID-19 measures in Panama were associated with a decrease in casual sex among cis-men and Afro-descendant peoples, whilst access to HIV/STI testing and care was seriously disrupted. +
++Background: The B.1.617.2 COVID-19 variant has contributed to the surge in cases in India and has now been detected across the globe, including a notable increase in cases in the UK. We estimate the effectiveness of the BNT162b2 and ChAdOx1 COVID-19 vaccines against this variant. Methods: A test negative case control design was used to estimate the effectiveness of vaccination against symptomatic disease with both variants over the period that B.1.617.2 began circulating with cases identified based on sequencing and S-gene target status. Data on all symptomatic sequenced cases of COVID-19 in England was used to estimate the proportion of cases with B.1.617.2 compared to the predominant strain (B.1.1.7) by vaccination status. Results: Effectiveness was notably lower after 1 dose of vaccine with B.1.617.2 cases 33.5% (95%CI: 20.6 to 44.3) compared to B.1.1.7 cases 51.1% (95%CI: 47.3 to 54.7) with similar results for both vaccines. With BNT162b2 2 dose effectiveness reduced from 93.4% (95%CI: 90.4 to 95.5) with B.1.1.7 to 87.9% (95%CI: 78.2 to 93.2) with B.1.617.2. With ChAdOx1 2 dose effectiveness reduced from 66.1% (95% CI: 54.0 to 75.0) with B.1.1.7 to 59.8% (95%CI: 28.9 to 77.3) with B.1.617.2. Sequenced cases detected after 1 or 2 doses of vaccination had a higher odds of infection with B.1.617.2 compared to unvaccinated cases (OR 1.40; 95%CI: 1.13-1.75). Conclusions: After 2 doses of either vaccine there were only modest differences in vaccine effectiveness with the B.1.617.2 variant. Absolute differences in vaccine effectiveness were more marked with dose 1. This would support maximising vaccine uptake with two doses among vulnerable groups. +
+Recombinant Hyperimmune Polyclonal Antibody (GIGA-2050) in COVID-19 Patients - Condition: COVID-19
Intervention: Drug: GIGA-2050
Sponsor: GigaGen, Inc.
Not yet recruiting
Study to Evaluate the Effects of RO7496998 (AT-527) in Non-Hospitalized Adult and Adolescent Participants With Mild or Moderate COVID-19 - Condition: COVID-19
Interventions: Drug: RO7496998; Drug: Placebo
Sponsors: Atea Pharmaceuticals, Inc.; Hoffmann-La Roche
Recruiting
The Effect of Vitamin D Supplementation on COVID-19 Recovery - Condition: Covid19
Interventions: Drug: Vit-D 0.2 MG/ML Oral Solution [Calcidol]; Drug: Physiological Irrigating Solution
Sponsors: University of Monastir; Loussaief Chawki; Nissaf Ben Alaya; Cyrine Ben Nasrallah; Manel Ben Belgacem; Hela Abroug; Imen Zemni; Manel Ben fredj; Wafa Dhouib
Completed
Using Text Messages to Improve COVID-19 Vaccination Uptake - Condition: Covid19
Intervention: Behavioral: Text message content
Sponsors: Imperial College Healthcare NHS Trust; Central London CCG; Imperial College Health Partners; Institute for Global Health Innovations; The Behavioural Insights Team
Not yet recruiting
A Study to Evaluate the Safety and Effect of STC3141 Continuous Infusion in Subjects With Severe Corona Virus Disease 2019(COVID-19)Pneumonia - Condition: Severe COVID-19 Pneumonia
Intervention: Drug: STC3141
Sponsors: Grand Medical Pty Ltd.; Trium Clinical Consulting
Not yet recruiting
Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC) - Condition: Covid19
Interventions: Drug: Ivermectin; Other: Placebo
Sponsor: Ministry of Public Health, Argentina
Recruiting
Mix and Match of the Second COVID-19 Vaccine Dose for Safety and Immunogenicity - Condition: COVID-19
Interventions: Biological: mRNA-1273 SARS-CoV-2 vaccine; Biological: BNT162b2; Biological: ChAdOx1-S [recombinant]; Other: 0, 28 day schedule; Other: 0, 112 day schedule
Sponsors: Canadian Immunization Research Network; Canadian Center for Vaccinology; BC Children’s Hospital Research Institute; Children’s Hospital Research Institute of Manitoba; CHU de Quebec-Universite Laval; Ottawa Hospital Research Institute; Northern Alberta Clinical Trials + Research Centre; Ontario Agency for Health Protection and Promotion; University of Toronto; Massachusetts General Hospital
Not yet recruiting
The Role of High Dose Co-trimoxazole in Severe Covid-19 Patients - Condition: COVID-19 Pneumonia
Interventions: Drug: Co-trimoxazole; Drug: Placebo
Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Not yet recruiting
Anti COVID 19 Intravenous Immunoglobulin (C-IVIG) Therapy for Severe COVID-19 Patients - Condition: Covid19
Intervention: Biological: Anti COVID 19 Intravenous Immunoglobulin (C-IVIG)
Sponsors: Dow University of Health Sciences; Higher Education Commission (Pakistan)
Recruiting
CRP-Apheresis for Attenuation of Pulmonary, MYocardial and/or Kidney Injury in COvid-19 - Condition: Covid19
Intervention: Device: CRP-apheresis
Sponsor: University Hospital, Essen
Recruiting
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients - Condition: COVID-19 Pneumonia
Intervention: Biological: Mesenchymal Stem Cells Transplantation
Sponsors: SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi; Istinye University; Liv Hospital (Ulus)
Completed
A Global Phase III Clinical Trial of Recombinant COVID-19 Vaccine (Sf9 Cells) - Condition: COVID-19
Interventions: Biological: Recombinant COVID-19 vaccine (Sf9 cells); Other: Placebo control
Sponsors: Jiangsu Province Centers for Disease Control and Prevention; WestVac Biopharma Co., Ltd.; West China Hospital
Not yet recruiting
ACTIV-6: COVID-19 Study of Repurposed Medications - Condition: Covid19
Intervention: Drug: Ivermectin Tablets
Sponsors: Susanna Naggie, MD; National Center for Advancing Translational Science (NCATS); Vanderbilt University Medical Center
Not yet recruiting
Amantadine for COVID-19: A Randomized, Placebo Controlled, Double-blinded, Clinical Trial - Condition: Covid19
Interventions: Drug: Amantadine; Drug: Lactose monohydrate
Sponsors: Copenhagen University Hospital, Hvidovre; University of Copenhagen
Not yet recruiting
3R Rehabilitation Management of COVID-19 Survivors - Condition: Covid19
Interventions: Other: Cardiopulmonary exercise (centre-based); Other: Cardiopulmonary exercise (online-based)
Sponsors: The Hong Kong Polytechnic University; Pamela Youde Nethersole Eastern Hospital, Hong Kong; Queen Elizabeth Hospital, Hong Kong; Princess Margaret Hospital, Hong Kong; Tuen Mun Hospital Hong Kong
Recruiting
Arginine Methylation of SARS-Cov-2 Nucleocapsid Protein Regulates RNA Binding, its Ability to Suppress Stress Granule Formation and Viral Replication - Viral proteins are known to be methylated by host protein arginine methyltransferases (PRMTs) necessary for the viral life cycle, but it remains unknown whether SARS-CoV-2 proteins are methylated. Herein, we show that PRMT1 methylates SARS-CoV-2 nucleocapsid (N) protein at residues R95 and R177 within RGG/RG motifs, preferred PRMT target sequences. We confirmed arginine methylation of N protein by immunoblotting viral proteins extracted from SARS-CoV-2 virions isolated from cell culture. Type I…
Binding mode characterization of 13b in the monomeric and dimeric states of SARS-CoV-2 main protease using molecular dynamics simulations - The main protease, M(pro)/3CL(pro), plays an essential role in processing polyproteins translated from viral RNA to produce functional viral proteins and therefore serve as an attractive target for discovering COVID-19 therapeutics. The availability of both monomer and dimer crystal bound with a common ligand, ‘13b’ (α-ketoamide inhibitor), opened up opportunities to understand the M^(pro) mechanism of action. A comparative analysis of both forms of M^(pro) was carried out to elucidate the…
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome - Programmed ribosomal frameshifting is a key event during translation of the SARS-CoV-2 RNA genome allowing synthesis of the viral RNA-dependent RNA polymerase and downstream proteins. Here we present the cryo-electron microscopy structure of a translating mammalian ribosome primed for frameshifting on the viral RNA. The viral RNA adopts a pseudoknot structure that lodges at the entry to the ribosomal mRNA channel to generate tension in the mRNA and promote frameshifting, whereas the nascent…
High-performance antiviral nano-systems as a shield to inhibit viral infections: SARS-CoV-2 as a model case study - Despite significant accomplishments in developing efficient rapid sensing systems and nano-therapeutics of higher efficacy, the recent coronavirus disease (COVID-19) pandemic is not under control successfully because the severe acute respiratory syndrome virus (SARS-CoV-2, original and mutated) transmits easily from human to -human and causes life-threatening respiratory disorders. Thus, it has become crucial to avoid this transmission through precautions and keep premises hygienic using…
Comparison of the coagulopathies associated with COVID-19 and sepsis - CONCLUSIONS: High levels of both EVTF activity and active PAI-1 may promote thrombosis in patients with COVID-19 due to simultaneous activation of coagulation and inhibition of fibrinolysis. The high levels of active PAI-1 in patients with COVID-19 may limit plasmin degradation of crosslinked fibrin and the release of d-dimer. This may explain the lower levels of D-dimer in patients with COVID-19 compared with patients with sepsis.
Interleukin-13 as a target to alleviate severe coronavirus disease 2019 and restore lung homeostasis - The ongoing coronavirus disease (COVID-19) pandemic urgently requires the availability of interventions that improve outcomes for those with severe disease. Since severe acute respiratory syndrome coronavirus 2 infection is characterized by dysregulated lung mucosae, and that mucosal homeostasis is heavily influenced by interleukin (IL)-13 activity, we explore recent findings indicating that IL-13 production is proportional to disease severity. We propose that excessive IL-13 contributes to the…
Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico Approach - SARS-CoV-2 infection across the world has led to immense turbulence in the treatment modality, thus demanding a swift drug discovery process. Spike protein of SARS-CoV-2 binds to ACE2 receptor of human to initiate host invasion. Plethora of studies demonstrate the inhibition of Spike-ACE2 interactions to impair infection. The ancient Indian traditional medicine has been of great interest of Virologists worldwide to decipher potential antivirals. Hence, in this study, phytochemicals (1,952…
Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19 - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) through excessive end organ inflammation. Despite improved understanding of the pathophysiology, management, and the great efforts worldwide to produce effective drugs, death rates of COVID-19 patients remain unacceptably high, and effective treatment is unfortunately lacking. Pharmacological strategies aimed at modulating inflammation in COVID-19 are being evaluated worldwide….
Calendulaglycoside A Showing Potential Activity Against SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and SAR Studies - BACKGROUND AND AIM: The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To this end, natural products can provide therapeutic alternatives that could be employed as an effective safe treatment for COVID-19.
Discovery of (E)-N-(4-cyanobenzylidene)- 6-fluoro- 3-hydroxypyrazine-2 -carboxamide (cyanorona-20): the first potent and specific anti-COVID-19 drug - ABSTRACT: Specific inhibition of the viral RNA-dependent RNA polymerase (RdRp) of the newly-emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising strategy for developing highly potent medicines for coronavirus disease 2019 (COVID-19). However, almost all of the reported viral RdRp inhibitors (either repurposed drugs or new antiviral agents) lack selectivity against the SARS-CoV-2 RdRp. Herein, I discovered a new favipiravir derivative,…
Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin - The COVID-19 pandemic as the largest global public health crisis is now considered as an emergency at the World Health Organization (WHO). As there is no specific therapy for SARS-CoV-2 infection at present and also because of the long time it takes to discover a new drug and the urgent need to respond urgently to a pandemic infection. Perhaps the best way right now is to find an FDA-approved drug to treat this infection. Oxidative stress and inflammation play a vital role in the progression of…
SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis - Higher selenium status has been shown to improve the clinical outcome of infections caused by a range of evolutionally diverse viruses, including SARS-CoV-2. However, the impact of SARS-CoV-2 on host-cell selenoproteins remains elusive. The present study investigated the influence of SARS-CoV-2 on expression of selenoprotein mRNAs in Vero cells. SARS-CoV-2 triggered an inflammatory response as evidenced by increased IL-6 expression. Of the 25 selenoproteins, SARS-CoV-2 significantly suppressed…
Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccines - A SARS-like coronavirus 2 (SARS-CoV-2) has caused a pandemic Coronavirus Disease 2019 (COVID-19) that killed more than 3.3 million people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of its spike protein to bind a host receptor, the angiotensin-converting enzyme 2 (ACE2), to gain entry. Currently, several mRNA or adenoviral vaccines encoding for the spike protein of SARS-CoV-2 are being used to boost antibodies capable of inhibiting spike-ACE2 interaction…
Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type III polyketide synthase - Antibiotic resistance and emerging viral pandemics have posed an urgent need for new anti-infective drugs. By screening our microbial extract library against the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the notorious ESKAPE pathogens, an active fraction was identified and purified, leading to an initial isolation of adipostatins A (1) and B (2). In order to diversify the chemical structures of adipostatins toward enhanced biological activities, a type III…
Lipopeptide-based pan-CoV fusion inhibitors potently inhibit HIV-1 infection - No abstract
METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA) - - link
IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR - - link
DEEP LEARNING BASED SYSTEM FOR DETECTION OF COVID-19 DISEASE OF PATIENT AT INFECTION RISK - The present invention relates to Deep learning based system for detection of covid-19 disease of patient at infection risk. The objective of the present invention is to solve the problems in the prior art related to technologies of detection of covid-19 disease using CT scan image processing. - link
A COMPREHENSIVE DISINFECTION SYSTEM DURING PANDEMIC FOR PERSONAL ITEMS AND PROTECTIVE EQUIPMENT (PPE) TO SAFEGUARD PEOPLE - The current Covid-19 pandemic has led to an enormous demand for gadgets / objects for personal protection. To prevent the spread of virus, it is important to disinfect commonly touched objects. One of the ways suggested is to use a personal UV-C disinfecting box that is “efficient and effective in deactivating the COVID-19 virus. The present model has implemented the use of a UV transparent material (fused silica quartz glass tubes) as the medium of support for the objects to be disinfected to increase the effectiveness of disinfection without compromising the load bearing capacity. Aluminum foil, a UV reflecting material, was used as the inner lining of the box for effective utilization of the UVC light emitted by the UVC lamps. Care has been taken to prevent leakage of UVC radiation out of the system. COVID-19 virus can be inactivated in 5 minutes by UVC irradiation in this disinfection box - link
UBIQUITOUS COMPUTING SYSTEM FOR MENTAL HEALTH MONITORING OF PERSON DURING THE PANDEMIC OF COVID-19 - - link
USE OF IMINOSUGAR COMPOUND IN PREPARATION OF ANTI-SARS-COV-2 VIRUS DRUG - - link
一种高灵敏SARS-CoV-2中和抗体的检测方法、检测试剂盒 - 本发明公开了一种高灵敏SARS‑CoV‑2中和抗体的检测方法、检测试剂盒,属于生物医学检测技术领域,本发明试剂盒包括层析试纸、卡壳和样本稀释液,所述层析试纸包括底板、样品垫、结合垫、NC膜和吸水垫,所述NC膜上依次设置有捕获线、检测线和质控线,所述捕获线包被有ACE2蛋白,所述检测线包被有RBD蛋白,所述结合垫设置有RBD蛋白标记物;本发明采用阻断法加夹心法原理提高检测中和抗体的灵敏度,通过添加捕获线的方式,将靶向RBD的非中和抗体提前捕获,保证后续通过夹心法检测中和抗体的特异性。 - link
逆转录酶突变体及其应用 - 本发明提供一种MMLV逆转录酶突变体,在野生型MMLV逆转录酶氨基酸序列(如SEQ ID No.1序列所示)中进行七个氨基酸位点的突变,氨基酸突变位点为:R205H;V288T;L304K;G525D;S526D;E531G;E574G。该突变体可以降低MMLV逆转录酶对Taq DNA聚合酶的抑制作用,大大提高了一步法RT‑qPCR的灵敏度。 - link
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Konstruktion einer elektrochemischen medizinischen Atemmaske (1) für den aktiven Schutz gegen Infektion mit Coronaviren dadurch gekennzeichnet, dass ein elektrochemischer Effekt durch eine allgemein positives Magnetfeld der Maske erzeugbar ist, das die positiv geladenen Coronavirus-Mikroorganismen von der Person vertreibt, indem eine aktive elektrochemische Atemmaske (1) aus einem zweischichtigen Material verwendet wird, umfassend eine äußeren Schicht (2) aus einer hochmolekularen Verbindung aus Bambus in Mischung mit Kupfer-, Silber- oder Goldmetallfasern und einer inneren Schicht (3) aus einem Vliesstoff auf Basis von Polypropylenfasern SMS oder SNS, wobei der Maskenkörper aus zwei in der Mitte der Gesichtssymmetrie genähten Elementen gebildet ist, um die Kontur der Gesichtskurven so weit wie möglich zu wiederholen, ausgestattet mit einem Atemfilter (9) mit einem Einsatz aus zwei Schichten ferromagnetischen Metallgewebes, wobei das Filter (9) hat eine herausnehmbare SMS- oder SNS-Vlieskartusche in einem Kunststoffrand (14) und eine Öse zur Fixierung im Filtergehäuse umfasst, wobei die Maske (1) jeweils einen Nasen- und Kinnbügel aus einem flexiblen Einschubstreifen zwischen den beiden Lagen des Maskengewebes aufweist, die eine Fixierung auf Basis von doppelseitig klebendem Silikonklebeband in den Maskenseitenkanten sowie Nacken- und Kopfbefestigungsschlaufen ermöglichen.
Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection - - link
The High Price of a New York City Cop - One of the city’s star officers has cost taxpayers more than two and a half million dollars in police-misconduct settlements. - link
How Hacking Became a Professional Service in Russia - The outfit behind the Colonial Pipeline attack had a blog, a user-friendly interface, and a sliding fee scale for helping hackers cash in on stolen information. - link
Eric Adams Wants to CompStat New York City - As a cop, he spoke out against police abuse. As a mayoral front-runner, he’s speaking up for the police. - link
Bitcoin’s Troubles Go Far Beyond Elon Musk - Recent moves by China have exposed the vulnerability of the cryptocurrency. - link
A Liberal Zionist’s Move to the Left on the Israeli-Palestinian Conflict - Peter Beinart, once a staunch defender of Israel, is arguing for the Palestinians’ right to return. - link
+The particular ennui of being a social media star is a microcosm of what’s happening to us all. +
++Earlier this month, the writer and English professor Barrett Swanson published a story in Harper’s about his five days at Clubhouse, the collective of dozens of college-aged social media hopefuls living in a smattering of content mansions in Los Angeles. He emerged with the sneaking suspicion that maybe all of this is bad, not only for the world but for the influencers themselves. +
++“For a moment, I cannot remember who I am or why I am sitting here amid this sea of beautiful young people, all of them desperate for recognition, their whole lives ahead of them, empty at the absolute center,” he writes in the closing paragraph. “TikTok is a sign of the future, which already feels like a thing of the past. It is the clock counting down our fifteen seconds of fame, the sound the world makes as time is running out.” +
++It’s easily the best and most depressing piece of journalism about famous TikTokers I’ve ever read, a “Slouching Towards Bethlehem” for influencers. Here are some things Swanson witnesses on his visit: a 19-year-old who just made $60,000 by filming a Lady and the Tramp-style kiss with his girlfriend as sponcon for a chicken-fingers joint; a list of video ideas which includes “pranks” and “tuxedos”; a kid who, out of nowhere, claimed that “Hitler invented sex dolls” based on a TikTok he just watched; an influencer manager who appears to be in the thrall of QAnon; pervasive neglect for the influencers on the part of their managers; and repeated offers to help Swanson become a TikTok influencer himself, as though the only reason for visiting at all was, of course, to take a little piece of their celebrity for his own. +
++Mostly, though, he sees the extreme precarity that courses through every person, every thought, every action that occurs in the house. “Several times throughout my trip, I think I can see the toll this takes on them, a kind of pallid desperation that flickers across their faces,” he writes. “At one point, Brandon [one of the influencers] comes over and says, ‘The scary thing is you never know how long this is going to last, and I think that’s what eats a lot of us at night. It’s like, What’s next? How long can we entertain everyone for? How long before no one cares, and what if your life was worth nothing?’” +
++It’s a topic I’ve discussed with almost every big TikToker I’ve interviewed, the question of what happens if and when it goes away. It’s a tough question to ask, but I’m always struck by the thoughtfulness of their answers: Whether they have 100,000 followers or a few million, all the TikTokers know that their fame will likely fade unless they work very, very hard to cultivate themselves into something solidly monetizable. They seamlessly toggle between their two identities — the real person and the online persona — and speak with a kind of cynicism about tying their livelihoods to a platform that could disappear in an instant. It all feels like stuff they shouldn’t have to think about, not yet. +
++What the piece doesn’t include are the other things that come with being a famous TikToker. Namely, that operations such as Clubhouse are often run by people who either have no clue what they’re doing thanks to the extremely low barrier to entry into such a field, or are actively harming the influencers they claim to help. +
++Clubhouse’s founder, Amir Ben-Yohanan, has been accused of bullying, sexism, and creating volatile atmospheres. Chase Zwernemann, the manager in Swanson’s story who shows him a QAnon video, has allegedly scammed other TikTokers at a previous content house. Many TikTokers are taken in by sketchy managers who sign them to predatory contracts because of the nature of how TikTok fame operates: When you get famous overnight, you’re not given time to learn the ropes. +
++And that’s only if you become famous enough to get lucrative brand deals. For the majority of kids who go viral on TikTok, the attention doesn’t last. “I wish I never got this sort of fame,” a 16-year-old former TikToker named Sam told me last year. He’d been creating delightfully bizarre videos that earned him a following of nearly 200,000, until suddenly the view counts started to drop and it felt like the audience didn’t like him anymore. He left the platform and sought therapy for the anxiety he’d developed due to TikTok. +
++Lots of TikTokers bring this up. They’re afraid of branching out from whatever the algorithm decides it likes for fear of becoming a has-been, and they’re burned out by the churn of endlessly creating content they barely even like. Some have public meltdowns, others quit for good, while even the app’s biggest star Charli D’Amelio said she often feels overwhelmed by the constant negative attention. +
++A few days ago, the 19-year-old TikToker Spencewuah tearfully announced he was taking a break from TikTok after backlash from a perceived gaffe. He has more than 9 million followers, but as Kate Lindsay pointed out on her Substack Embedded, that doesn’t change the fact that he’s navigating fame alone. “Tons of midsize creators burn out or take breaks or disappear completely because they’re popular enough to amass giant followings but not to earn the kind of money it takes to insulate themselves from those followings. TikTok, of course, relies on these midsize creators,” she wrote. Yet besides making them famous, TikTok the company doesn’t seem to do much to help them with its consequences. +
++What’s happening to influencers is a microcosm of what’s happening to everyone. At Clubhouse, Swanson connects the stars to his own university students, kids who write increasingly about their anxiety, depression, and suicidal ideation, kids who appear in his office “sad in a way they cannot explain, desperate for something they don’t know how to have.” +
++Several of them, he says, dropped out to move to LA to chase the influencer dream for themselves, hoping to become famous in the same way all the other kids got famous: By getting their face to appear on millions of other people’s screens. Left unsaid is what happens when they do win the TikTok lottery, and how the unexplainable sadness doesn’t really go away. +
++We’re seeing this in workplaces, too, most visibly in media. Journalists are leaving staff positions to start their own Substacks or Patreons, hoping to cash in their followings on the creator economy, the professional adult version of dropping out of college and moving to LA. Low-wage workers, disillusioned by the failures of bosses and owners to treat them fairly, aren’t returning to traditional jobs, and many are surely turning to the gig or creator economies. The influencer industry is simply the logical endpoint of American individualism, which leaves all of us jostling for identity and attention but never getting enough. +
++What these anxious influencers need is help, help from people who are not also trying to squeeze every last dollar out of them. Lindsay proposed that TikTok and other social media platforms provide therapy for struggling creators, which seems like a viable and promising possibility, however dystopian the idea of a company creating so many mental health problems that they then must directly fix them. +
++They need community, and not the kind of faux community promised by toxic content houses or publicity-designed friendships. They need meaning beyond the numbers on the screen, and they need to find ways to make content that is meaningful to them outside of the oppressive blandness that the algorithm rewards. These are things we all aren’t getting in our current social and economic systems. Influencers, who for better or for worse are increasingly society’s role models, are only the most public examples. +
++This column first published in The Goods newsletter. Sign up here so you don’t miss the next one, plus get newsletter exclusives. +
+Even if it could pass, McConnell and McCarthy likely won’t appoint commissioners who would work in good faith. +
++Days after the chaotic storming of the Capitol on January 6, some Republican members of Congress had an idea. +
++What the country needed, Reps. John Katko (R-NY), Rodney Davis (R-IL), and others decided, was a bipartisan commission, akin to the one established after 9/11, to sort through the facts and determine just how such a terrible breach of government security happened. +
++Now, though, the chances for such a commission are imperiled. A bill to establish it passed the House last Wednesday with support from every Democrat and 35 Republicans. But most others in the GOP, including party leaders, have come out strongly against the bill, with the party’s senators planning a filibuster. +
++Republicans have evidently calculated that such a commission’s findings would likely hurt their party’s electoral prospects. Some even admit this: “Anything that gets us rehashing the 2020 election, I think, is a day lost on being able to draw contrast between us and the Democrats’ very radical left-wing agenda,” Senate Minority Whip John Thune told reporters last week. +
++But even if a deal does somehow come together, there are real reasons to doubt whether such a commission would achieve anything substantial. +
++There’s nothing magical about this proposed bipartisan commission — it would have the same formal powers as any ordinary congressional committee looking into the matter. In fact, its requirement for bipartisan support to issue subpoenas means it could well be less aggressive at unearthing new information than, say, a Democratic-only House committee investigation could be. +
++Its hoped-for advantage would instead be in the realm of messaging. The idea is that if such a body is deemed above politics, it could deliver an assessment of what happened that would be viewed as credible by both sides, shaping a national narrative. +
++This second aim is what supporters of a January 6 commission are really hoping to achieve. The hope is that, if the reasonable Republicans and Democrats could only get together, they could reach consensus and sagely explain how and why the Capitol was stormed, and how the US can stop something like it from happening again. +
++It’s a doomed hope. +
++The bill passed by the House is deliberately modeled after the 9/11 commission — it calls for 10 commissioners, five from each party, who would be appointed by congressional leaders. So that earlier body is a useful comparison, with lessons for how such commissions can come to be deemed successful, and what they actually achieve. +
++The first lesson is about PR. The 9/11 Commission Report was published as a 567-page book which became a best-seller, and in the discourse, it was often treated as the definitive assessment on what had gone wrong. But this was not really because the commission discovered a ton of new information (a joint congressional committee had already finished a report with largely similar facts), or because everything went smoothly (there were many politicized disputes and much important information was withheld). +
++One reason is that, as Philip Shenon (author of a book on the commission) recently argued in an interview with Just Security, the report was “packaged” better — many remarked that it read more like a novel than a policy document. Additionally, the two savvy moderate retired politicians in charge, former New Jersey Gov. Tom Kean, a Republican, and former Indiana Rep. Lee Hamilton, a Democrat, effectively became joined at the hip to tout the final product as truly bipartisan and credible. +
++But what’s crucial here is that, in the end, Kean and Hamilton wanted to tout a bipartisan product. This time around, from the start, Republicans oppose the very idea of the commission. Their appointees will be hand-picked by McConnell and House Minority Leader Kevin McCarthy, who are more likely to choose commissioners prone to obstruct and object, not to lend the eventual report a bipartisan halo. +
++The second lesson is about politics. The sunny view of bipartisan commissions is that members of both parties boldly manage to put politics aside and do the right thing for the country. The more cynical and probably more realistic way to look at them is that politics never truly leaves the process — especially when the issue has serious electoral implications for both parties. +
++The question of who in the US government deserved blame for the September 11, 2001 attacks had potentially monumental implications for both parties. Republicans had blamed Bill Clinton for failing to act against Osama bin Laden while he was president in the late 1990s, while Democrats had blamed George W. Bush for ignoring warnings in the advance of the attacks themselves. The report was crafted as Bush’s reelection was looming, and with widespread speculation that Hillary Clinton would run for president one day. +
++The 9/11 commissioners achieved bipartisan unanimity despite all this. But they did so essentially by ensuring the final report would be “balanced,” and wouldn’t single out either president for overmuch blame. Critics from either side would argue that the desire for bipartisanship resulted in something like a whitewash. +
++The storming of the Capitol is an issue with very different partisan dynamics, and it’s difficult to imagine what a “balanced” report on it could look like. Any broad and serious assessment of what happened only has a realistic chance of making one party — the party of Donald Trump — look bad. And Republicans have been very clear that, for electoral reasons, they don’t want to do this. +
++Even though Republicans would likely be able to prevent a bipartisan 1/6 commission from achieving much of substance, they’d really prefer not to have one at all. +
++That’s because, as Thune admitted above and as Liz Cheney’s ouster shows, party strategists view any discussion of Trump’s attempt to overturn the election result as a harmful issue for their party at this point. They want to make the 2022 elections about Biden and Democrats, not Trump. +
++Parties prefer issues that unite their own members and put their opponents on the defensive. But on this topic, it’s clearly Republicans who are on the defensive. The GOP base is out of step with public opinion on this issue. So they’d really like it to just go away. +
++Democrats, meanwhile, have electoral incentives to try and keep the storming of the Capitol in the news however they can. “Democrats should spend every day tying all of it to the Republican Party,” political consultant James Carville recently told my colleague Sean Illing. (McConnell has reportedly been sharing that interview to argue that Democrats are motivated by politics here.) +
++So if electoral and messaging advantage is the true goal, the commission would still be worthwhile for Democrats. But feel-good bipartisanship isn’t in the cards, and fact-finding would probably be difficult too if the Republican commissioners agree to vote as a bloc against any controversial subpoenas. +
++In any event, theories of how such a commission would play out are probably moot, unless there’s a surprising sudden shift in Senate Republicans’ thinking. +
++Currently, there are a few Senate Republicans, like Susan Collins (R-ME) and Mitt Romney (R-UT), who sound open to supporting a changed version of the bill (Collins wants the staff to be bipartisan, and Romney wants to ensure that they’ll finish by their end-of-year deadline). Many others, though, are dug in firmly against the idea and seem immovable. So the current betting is that the 10 GOP votes needed to overcome a filibuster will not materialize. +
++What, then, can Democrats do instead? +
++It’s useful again to remember the two main things such a commission can do — fact-finding and narrative-shaping. +
++As far as formal fact-finding powers go, a congressional committee can do everything a bipartisan commission can do; namely, it can hold hearings and issue subpoenas. One advantage the commission might have is unified focus on one topic — but that could also be achieved by establishing a special “select committee” to investigate January 6, as House Republicans did for Benghazi. +
++In the House, Democrats have majorities on every committee, so they can issue whatever subpoenas they want. The story is more complicated in the Senate, where committees are evenly divided due to the chamber’s 50-50 split. According to an analysis from the law firm Covington & Burling LLP, the only senator who can unilaterally issue a subpoena without Republican support is Jon Ossoff (D-GA), who chairs an investigations subcommittee. It’s not entirely clear whether committees could potentially elevate blocked subpoenas to a full Senate vote, but it may be possible. +
++Still, as Norm Ornstein, at the conservative American Enterprise Institute think tank, recently pointed out in an interview with the Washington Post’s Greg Sargent, while “congressional subpoena power is theoretically extraordinarily powerful,” it’s clear that “practically it can be subverted fairly easily.” Ornstein added: “We’ve seen instance after instance of people defying subpoenas, taking it to court, and stretching it out for years.” In practice, as we saw with various hearings during the Trump years, congressional committees are most successful with willing witnesses who want to hand over documents or testify (often technically under subpoena for legal cover). +
++And when it comes to shaping the narrative, it does seem that congressional committees would, more likely, be deemed partisan by the media, as compared to a special bipartisan commission. But the hope to establish one consensus national narrative around the events of January 6 was always a pipe dream. +
++Most Republican voters now inhabit an information environment dominated by conservative media outlets like Fox and social media similarly designed to tell them what they want to hear. Acknowledging that reality, the most Democrats may be able to do is push on forward, trying to gather facts and make a public case to their best of their ability — on their own. +
+The vaccines are holding Covid-19 down in the US for now, but it could come back this fall. +
++You’ve heard it before, but it’s true: This summer in America is going to be so good. After a year of Covid-19-induced fear, the US vaccination campaign and warmer weather will give the country a much-needed reprieve from the coronavirus and all the horrors it brought. +
++But what comes after the summer? +
++Last year, we saw that the coronavirus spreads more easily in the fall and winter than it does in warmer months. More than 330,000 Americans died from Covid-19 over six months during the fall and winter — an unimaginable death toll, amounting to nearly nine times all car crash deaths in 2019 and more than 17 times all murders. +
++One cause was the country’s relaxed response to the coronavirus, as much of America dropped its guard and precautions. But experts also blame the seasonality of Covid-19, as falling temperatures pushed people indoors, where the virus has an easier time spreading, and families gathered for the holiday season. +
++America is in a much better place than it was last fall and winter. A combination of the vaccines and natural immunity from past Covid-19 infections is suppressing the virus. But the country isn’t totally in the clear yet: The majority of the US population still isn’t vaccinated, and the rate of daily vaccinations has dramatically slowed, now standing at about half of what it was at its peak in mid-April. +
++Then there are the coronavirus variants. The vaccines do a good job overpowering the known variants, based on the research, but at least some variants do seem to overcome some natural immunity. So people in the US who are unvaccinated but have had Covid-19 before might still be vulnerable. Some experts also worry that natural immunity from a previous infection might not be durable — perhaps fading over time, potentially in time for a fall wave. (There are similar concerns about the vaccines, but vaccine-induced immunity so far has proven to be better than natural immunity in research trials.) +
++There’s a risk, too, that the warmer weather and potential seasonality of the virus will in some sense give the country a false sense of security. By letting much of the US (though not all) safely socialize outside, while Covid-19 cases and deaths continue to decline, there’s a risk that people will move on from the virus too quickly — and the remaining unvaccinated will come to believe, if they don’t already, that they don’t really need to get the shot. +
++All of these factors — the holidays, colder weather, variants, and at least some immunity potentially dropping off — could combine to create a Covid-19 comeback this fall and winter. The experts I’ve talked to don’t believe this will be a huge, nationwide surge — too many will be vaccinated by the fall for that to happen. But particularly in parts of the country with low vaccination rates, there could be local or state-level spikes of the coronavirus. +
++“It could happen — if we really stall in our vaccination coverage,” Jen Kates, director of global health and HIV policy at the Kaiser Family Foundation, told me. “If we increase our vaccination coverage, I’m less worried about that.” +
++This isn’t a reason to despair. Especially if you’re vaccinated, you’re extremely safe from Covid-19. Rather, this is a call for more people to get vaccinated — it’s the one way the country can guarantee another fall or winter surge never comes. +
++The news on Covid-19 in the US is genuinely incredible right now. Almost half the country has had at least one vaccine dose. Daily new coronavirus cases are less than a 10th of what they were during a January peak, and deaths are down more than 85 percent from January as well. The higher vaccination rates, decline in cases and deaths, and warmer weather will soon, if they haven’t already, let us safely engage in the kinds of social interactions that were dangerous just a year ago. +
++This is all genuinely fantastic, thrilling news. Personally, I’m planning trips and vacations that I would have been too scared to do a year ago. I no longer wear a mask unless it’s required by law or by the businesses I’m patronizing. I’ll very soon see friends and family that I haven’t seen in a long time. As someone who’s vaccinated, I just don’t worry about my own risk of Covid-19 at all anymore — and many experts share that view as well. +
++But this optimism can be taken a bit too far. As much as things have improved, they’re not completely back to normal yet. Covid-19 cases and deaths are still near or above levels that were considered fairly high last summer. More than 60 percent of the country still isn’t fully vaccinated, and more than half haven’t gotten at least one shot. In some states, rates of vaccination are even lower — with two-thirds of the population not getting one shot yet. +
++“It’s good to celebrate at this stage,” Mauricio Santillana, a researcher at Harvard Medical School and Boston Children’s Hospital, told me. “But we cannot be fully confident that this is the end of it.” +
++That large unvaccinated population means a lot of people remain vulnerable to the virus. We don’t know what level of vaccination is needed for herd immunity (the level of immunity that ensures infections won’t spread within a community), but experts believe it will require at least 60 percent of the population vaccinated and perhaps as high as 85 or 90 percent, depending in part on the variants we’re dealing with. +
++The remaining vulnerabilities could grow, too. Natural immunity could fade over time, or more infectious variants could pop up. As fall arrives and the weather cools, people will shift activities back to poorly ventilated indoor environments where airborne viruses can more easily spread. People could drop their guard too much, especially if Covid-19 cases continue to decline over the summer. +
++“I do think in the fall and winter, things will be much better,” Ashish Jha, dean of the Brown University School of Public Health, told me. “But we may very well see a bump, and we may need to put in some mild public health restrictions for short periods of time if we see surges in cases.” He added, “We have to be ready.” +
++Imagine a potential scenario: Cases and deaths continue to drop. The summer brings a renewal of social activities. Covid-19 starts to look like a thing of the past. Covid-related precautions, legal and voluntary, are widely discarded. In this environment, people who have yet to get the vaccine decide maybe they don’t need to — after all, the virus isn’t really a present threat anymore. So cases and deaths drop, but so do vaccination rates. +
++Then the fall comes. More people move indoors, travel, and gather for the holidays. Maybe a new variant becomes the dominant form of the virus in the US. At the same time, perhaps natural immunity is weakened. In a few parts of the country, such as the South and Midwest, a lot of the population remains unvaccinated. Suddenly, the virus starts to pick up locally, or maybe even beyond that, especially if vaccination rates are low statewide. Local and state governments may be slow to react, resistant to reinstituting restrictions they had only recently celebrated the end of. +
++This scenario isn’t guaranteed. Maybe the vaccines are so great that it turns out America’s current vaccination rates, along with natural immunity that perhaps turns out more durable than previously thought, is enough to keep the coronavirus at bay. +
++But it’s a risk. And it’s an unnecessary one given that there is a good way to avoid it. +
++The vaccines are great. Evidence from clinical trials and the real world has found that they nearly eliminate the risk of serious illness, hospitalization, and death from Covid-19. In Israel, which has the world’s most advanced vaccination campaign, a vaccination rate of 60 percent has let the country remain nearly fully open and see daily Covid-19 deaths fall to the single digits or zero — a big improvement for a country that experienced some of the worst coronavirus surges in the world. +
++But the vaccines can only do their thing if more people get vaccinated. America is not at Israel’s 60 percent rate. And there’s a good chance the US will have to go higher than that — given that Israel’s reopening still involves mask mandates and vaccine passports, both of which Americans are increasingly rejecting. +
++As long as there are “pockets of people who choose not to vaccinate, you leave the door open for Covid to come back,” Santillana said. “We need to stay vigilant.” +
++For lawmakers and other leaders, that means doing more work to get people vaccinated. Experts have called for a three-tiered approach: improving access, providing incentives, and imposing some mandates if necessary. That could mean, at the state level, partnering with entertainment and transportation venues to offer shots on-site, providing financial or other material rewards to the vaccinated, and pushing schools, including colleges, to require vaccinations. It could also mean, on the private side, employers offering vaccines on-site, handing out pay bonuses to the vaccinated, and making vaccination required to come back to the office. +
++For the public, that means more people choosing to get vaccinated. One thing that could help here is vaccinated people sharing their stories, given that almost one in five people is in wait-and-see mode with the vaccines, largely standing by until the people around them get the shot. +
++America just got through a pandemic year with so much uncertainty. It has a chance to stamp out one of the last bits of uncertainty — and the risk of another fall and winter surge — if as many people as possible get vaccinated. But it’s on everyone to make that happen. +
Indian men and women’s squads begin hard quarantine ahead of England tour - The Indian women’s team members also entered their eight-day hard quarantine at the Grand Hyatt in Mumbai located near the international airport.
Govt. to open 143 Khelo India centres across 7 states - These centres will be set up in Maharashtra, Mizoram, Goa, Karnataka, Madhya Pradesh, Arunachal Pradesh and Manipur
Naseem Shah expelled from Pakistan Super League for violating COVID-19 protocols - The 18-year-old fast bowler reportedly had an outdated COVID-19 negative certificate with him.
England vs India series itinerary unlikely to change after ECB-BCCI back-channel talks - It is learnt that the informal discussions between the bigwigs of both boards have not yielded any favourable result.
Phil Mickelson — fabulous at fifty - Defies age to win PGA Championship, the oldest to win a Major
Lakshadweep administrator pursuing imperialist-corporate agenda, says Mohammed Faizal - The NCP member of Lok Sabha from the Lakshadweep group of islands, said that the administrator was acting in a way that disturbed the people
CBI chief selection: In dissent note, Adhir Ranjan questions conduct of DoPT - Congress leader asked for deferment of meeting of High Powered Committee
Care centres for migrant labourers to come up - As part of COVID-19 containment measures, various local bodies in the district will arrange domiciliary care centres for migrant labourers. The centre
Cyclone Yaas | Odisha shifts over 2 lakh people to cyclone shelters by 4 p.m. - Dry foods have been pre-positioned in shelters and three government officers would remain in charge of each shelter.
I urge PM Modi to take initiative for dialogue with Chief Ministers: Anand Sharma - Addressing the COVID-19 surge in the country, the Congress leader said it is time for Modi to walk the talk on cooperative federalism
EU agrees new Belarus sanctions after plane arrest - Belarusian airlines will be banned from EU skies after a flight was diverted and a journalist held.
Belarus plane: What action has the EU taken? - What sanctions are in place against Belarus and what new measures are being considered?
Belarus Ryanair flight diverted: Passengers describe panic on board - The plane changed course as it neared its destination leaving passengers shocked and confused.
Rocco Morabito: Italian fugitive arrested in Brazil - Rocco Morabito, who has been wanted since the 1990s, escaped from a prison in Uruguay in 2019.
Damiano David: Eurovision winner cleared of drug use by broadcaster - A test clears Måneskin’s lead singer of drug use during the competition’s grand final.
It’s ransomware, or maybe a disk wiper, and it’s striking targets in Israel - Dubbed Apostle, never-before-seen wiper masquerades as ransomware. - link
Bernie Sanders wants to stop NASA funding for Blue Origin - The Endless Frontier Act? More like the Endless Amendment Act. - link
Freenode IRC staff resign en masse after takeover by Korea’s crown prince - Former staffer alleges “a hostile entity is now in control… and has your data.” - link
Actively exploited macOS 0-day let hackers take screenshots of infected Macs - Apple patches vulnerability that malware used to bypass macOS privacy protections. - link
For research citations, no replication is no problem - Looking back at big replication projects, finding they don’t seem to have mattered. - link
+God snapped his fingers and it happened. The second person said the same thing and God did the same thing. This want on and on throughout the group. God noticed the last man in line was laughing hysterically. By the time God got to the last ten people, the last man was laughing and rolling on the ground. When the man’s turn came, he laughed and said, “I wish they were all ugly again.” +
+ submitted by /u/nikan69
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+Going to watch all documentaries this way now! +
+ submitted by /u/oblectoergosum
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+“No of course not”, replied his mother. Why would you think such a thing? +
++Fred showed her his genealogy DNA test results. No match for any of his relatives, and strong matches for a family who lived the other side of the city. +
++Perturbed, his mother called her husband. “Honey, Fred has done a DNA test, and… and… I don’t know how to say this… he may not be our son.” +
++“Well, obviously!” he replied. +
++“What do you mean?” +
++“It was your idea in the first place” her husband continued. “You remember, that first night in hospital when the baby did nothing but scream and cry and scream and cry. On and on. And you asked me to change him.” +
++“I picked a good one I reckon. Ever so proud of Fred.” +
+ submitted by /u/whyamihere999
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+And that’s Chris Brown +
+ submitted by /u/sambhav25
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+and he says “look son, first you swim full force at the human but at the last second, you turn away. Then you swim at him full force again, but again at the last second you swim away. Then you can go back and eat the human.” +
++The son looks confused and asks, “But dad, why can’t we just go eat the human the first time?” +
++Dad replies “Well, you can but why would you want to eat him when he’s still full of shit?” +
+ submitted by /u/sakatimi
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