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<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1> <h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul> <ul>
<li><strong>The Pandemic and my PhD: Lessons from a Policy Research Placement with the Reset Initiative</strong> -
<div>
In this brief reflection, I explore three key lessons learned from conducting a policy research placement during the COVID-19 pandemic. I explore how the placement changed my perspective on my PhD research, working life, and suggest how academics may better engage with policymakers in the future.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/jg67m/" target="_blank">The Pandemic and my PhD: Lessons from a Policy Research Placement with the Reset Initiative</a>
</div></li>
<li><strong>Making Virtual Teams Work: Redesigning Virtual Collaboration for the Future</strong> -
<div>
The COVID-19 pandemic has shifted how many teams work, from face-to-face interactions to remote and hybrid forms of collaboration. Even at its best, though, virtual collaboration remains less effective than face-to-face collaboration, leaving millions of workers with both the temporary and permanent challenges of virtual work. Virtual collaboration as we know it was designed in and for a colocated world without prioritizing diverse needs. Design is uniquely positioned to not only alleviate these ails but even make virtual teams strategically advantageous by developing solutions specifically for hybrid virtual collaboration. To do so, designers must incorporate attributes that make virtual collaboration “work”. This article provides background on communication technologies before summarizing the attributes of collaboration and leadership that “work” for effective virtual collaboration. We then highlight several outstanding concerns and possibilities as an impetus for designers and researchers to develop solutions to the challenges of sustained remote and hybrid collaboration. In doing so, we seek to motivate designers and researchers to redesign the artifact of virtual work itself for the fundamental needs of collaboration.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/wehsk/" target="_blank">Making Virtual Teams Work: Redesigning Virtual Collaboration for the Future</a>
</div></li>
<li><strong>SARS-CoV-2 infection causes transient olfactory dysfunction in mice</strong> -
<div>
Olfactory dysfunction caused by SARS-CoV-2 infection represents as one of the most predictive and common symptoms in COVID-19 patients. However, the causal link between SARS-CoV-2 infection and olfactory disorders remains lacking. Herein we demonstrate intranasal inoculation of SARS-CoV-2 induces robust viral replication in the olfactory epithelium (OE), resulting in transient olfactory dysfunction in humanized ACE2 mice. The sustentacular cells and Bowman’s gland cells in OE were identified as the major targets of SARS-CoV-2 before the invasion into olfactory sensory neurons. Remarkably, SARS-CoV-2 infection triggers cell death and immune cell infiltration, and impairs the uniformity of OE structure. Combined transcriptomic and proteomic analyses reveal the induction of antiviral and inflammatory responses, as well as the downregulation of olfactory receptors in OE from the infected animals. Overall, our mouse model recapitulates the olfactory dysfunction in COVID-19 patients, and provides critical clues to understand the physiological basis for extrapulmonary manifestations of COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.10.376673v1" target="_blank">SARS-CoV-2 infection causes transient olfactory dysfunction in mice</a>
</div></li>
<li><strong>Epidemiological transcriptomic data supports BCG protection in viral diseases including COVID-19</strong> -
<div>
Epidemiological evidence suggests that Bacille Calmette-Guerin (BCG) vaccine induced trained immunity protects against non-specific infections including coronavirus disease 2019 (COVID-19). A recent clinical trial has also supported BCG protection in viral respiratory infections in general, with multiple COVID-19 specific trials currently ongoing. The durability and mechanism of BCG trained immunity however remain unclear. An integrative analysis of available epidemiological transcriptomic data related to BCG vaccination and viral respiratory infections, along with transcriptomic alterations reported in COVID-19, is presented here toward addressing this gap. Results show that BCG vaccination leads to a very long-lasting transcriptomic changes which mimic viral infections by upregulated antiviral defense response, and oppose viral infections by downregulated myeloid cell activation mediated immune response. Antiviral defense upregulation is consistent with the present concept of trained immunity, whereas downregulation of myeloid cell activation seems directionally inconsistent, with enhancement of innate immune response considered to characterize trained immunity. The present finding is however in consonance with recent retrospective cohort study and clinical trial evidence that shows no association of BCG vaccination with systemic inflammation, alleviating the concern that the vaccine may add to inflammatory response and worsen severe COVID-19. In conclusion, the present analysis offers transcriptomic support to the existing epidemiological evidence of lower prevalence and mortality of COVID-19 in countries with childhood BCG vaccination policy.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.10.374777v1" target="_blank">Epidemiological transcriptomic data supports BCG protection in viral diseases including COVID-19</a>
</div></li>
<li><strong>Highly potent bispecific sybodies neutralize SARS-CoV-2</strong> -
<div>
The COVID-19 pandemic has resulted in a global crisis. Here, we report the generation of synthetic nanobodies, known as sybodies, against the receptor-binding domain (RBD) of SARS-CoV-2 spike protein. We identified a sybody pair (Sb#15 and Sb#68) that can bind simultaneously to the RBD, and block ACE2 binding, thereby neutralizing pseudotyped and live SARS-CoV-2 viruses. Cryo-EM analyses of the spike protein in complex with both sybodies revealed symmetrical and asymmetrical conformational states. In the symmetric complex each of the three RBDs were bound by both sybodies, and adopted the up conformation. The asymmetric conformation, with three Sb#15 and two Sb#68 bound, contained one down RBD, one up-out RBD and one up RBD. Bispecific fusions of the sybodies increased the neutralization potency 100-fold, as compared to the single binders. Our work demonstrates that linking two binders that recognize spatially-discrete binding sites result in highly potent SARS-CoV-2 inhibitors for potential therapeutic applications.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.10.376822v1" target="_blank">Highly potent bispecific sybodies neutralize SARS-CoV-2</a>
</div></li>
<li><strong>Protective efficacy of a SARS-CoV-2 DNA Vaccine in wild-type and immunosuppressed Syrian hamsters</strong> -
<div>
A worldwide effort to counter the COVID-19 pandemic has resulted in hundreds of candidate vaccines moving through various stages of research and development, including several vaccines in phase 1, 2 and 3 clinical trials. A relatively small number of these vaccines have been evaluated in SARS-CoV-2 disease models, and fewer in a severe disease model. Here, a SARS-CoV-2 DNA targeting the spike protein and delivered by jet injection, nCoV-S(JET), elicited neutralizing antibodies in hamsters and was protective in both wild-type and transiently immunosuppressed hamster models. This study highlights the DNA vaccine, nCoV-S(JET), we developed has a great potential to move to next stage of preclinical studies, and it also demonstrates that the transiently-immunosuppressed Syrian hamsters, which recapitulate severe and prolonged COVID-19 disease, can be used for preclinical evaluation of the protective efficacy of spike-based COVID-19 vaccine.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.10.376905v1" target="_blank">Protective efficacy of a SARS-CoV-2 DNA Vaccine in wild-type and immunosuppressed Syrian hamsters</a>
</div></li>
<li><strong>CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseases</strong> -
<div>
Studies on human monocytes historically focused on characterization of bulk responses, whereas functional heterogeneity is largely unknown. Here, we identified an inducible population of CD127-expressing human monocytes under inflammatory conditions and named the subset M127. M127 is nearly absent in healthy individuals yet abundantly present in patients with infectious and inflammatory conditions such as COVID-19 and rheumatoid arthritis. Multiple genomic and functional approaches revealed unique gene signatures of M127 and unified anti-inflammatory properties imposed by the CD127-STAT5 axis. M127 expansion correlated with mild COVID-19 disease outcomes. Thereby, we phenotypically and molecularly characterized a human monocyte subset marked by CD127 that retained anti-inflammatory properties within the pro-inflammatory environments, uncovering remarkable functional diversity among monocytes and signifying M127 as a potential therapeutic target for human inflammatory disorders.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.10.376277v1" target="_blank">CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseases</a>
</div></li>
<li><strong>A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples</strong> -
<div>
The COVID-19 pandemic is a once-in-a-lifetime event, exceeding mortality rates of the flu pandemics from the 1950’s and 1960’s. Whole-genome sequencing (WGS) of SARS-CoV-2 plays a critical role in understanding the disease. Performance variation exists across SARS-CoV-2 viral WGS technologies, but there is currently no benchmarking study comparing different WGS sequencing protocols. We compared seven different SARS-CoV-2 WGS library protocols using RNA from patient nasopharyngeal swab samples under two storage conditions. We constructed multiple WGS libraries encompassing three different viral inputs: 1,000,000, 250,000 and 1,000 copies. Libraries were sequenced using two distinct platforms with varying sequencing depths and read lengths. We found large differences in mappability and genome coverage, and variations in sensitivity, reproducibility and precision of single-nucleotide variant calling across different protocols. We ranked the performance of protocols based on six different metrics. Our results indicated that the most appropriate protocol depended on viral input amount and sequencing depth. Our findings offer guidance in choosing appropriate WGS protocols to characterize SARS-CoV-2 and its evolution.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.10.375022v1" target="_blank">A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples</a>
</div></li>
<li><strong>Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2</strong> - <li><strong>Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2</strong> -
<div> <div>
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally, and the number of cases continues to rise all over the world. Besides humans, the zoonotic origin, as well as intermediate and potential spillback host reservoirs of SARS-CoV-2 are unknown. To circumvent ethical and experimental constraints, and more importantly, to reduce and refine animal experimentation, we employed our airway epithelial cell (AEC) culture repository composed of various domesticated and wildlife animal species to assess their susceptibility to SARS-CoV-2. In this study, we inoculated well-differentiated animal AEC cultures of monkey, cat, ferret, dog, rabbit, pig, cattle, goat, llama, camel, and two neotropical bat species with SARS-CoV-2. We observed that SARS-CoV-2 only replicated efficiently in monkey and cat AEC culture models. Whole-genome sequencing of progeny virus revealed no obvious signs of nucleotide transitions required for SARS-CoV-2 to productively infect monkey and cat epithelial airway cells. Our findings, together with the previously reported human-to-animal spillover events warrants close surveillance to understand the potential role of cats, monkeys, and closely related species as spillback reservoirs for SARS-CoV-2. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally, and the number of cases continues to rise all over the world. Besides humans, the zoonotic origin, as well as intermediate and potential spillback host reservoirs of SARS-CoV-2 are unknown. To circumvent ethical and experimental constraints, and more importantly, to reduce and refine animal experimentation, we employed our airway epithelial cell (AEC) culture repository composed of various domesticated and wildlife animal species to assess their susceptibility to SARS-CoV-2. In this study, we inoculated well-differentiated animal AEC cultures of monkey, cat, ferret, dog, rabbit, pig, cattle, goat, llama, camel, and two neotropical bat species with SARS-CoV-2. We observed that SARS-CoV-2 only replicated efficiently in monkey and cat AEC culture models. Whole-genome sequencing of progeny virus revealed no obvious signs of nucleotide transitions required for SARS-CoV-2 to productively infect monkey and cat epithelial airway cells. Our findings, together with the previously reported human-to-animal spillover events warrants close surveillance to understand the potential role of cats, monkeys, and closely related species as spillback reservoirs for SARS-CoV-2.
@ -85,82 +141,12 @@ A vaccine, when available, will likely become our best tool to control the cur-
<div class="article-link article-html-link"> <div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.08.14.20175257v2" target="_blank">Vaccine optimization for COVID-19, who to vaccinate first?</a> 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.08.14.20175257v2" target="_blank">Vaccine optimization for COVID-19, who to vaccinate first?</a>
</div></li> </div></li>
<li><strong>The COVID-19 Pandemic and US Presidential Elections</strong> -
<div>
What is the effect of the COVID-19 pandemic on the 2020 U.S. presidential election? Guided by a pre-analysis plan, we estimate the effect of COVID-19 cases and deaths on the change in county-level voting for Donald Trump between 2016 and 2020. To account for potential confounders, we include a large number of COVID-19-related controls as well as demographic and socioeconomic variables. Moreover, we instrument the numbers of cases and deaths with the share of workers employed in meat-processing factories to sharpen our identification strategy. We find that COVID-19 cases negatively affected Trump’s vote share. The estimated effect appears strongest in urban counties, in swing states, and in states that Trump won in 2016. A simple counterfactual analysis suggests that Trump would likely have won re-election if COVID-19 cases had been 5 percent lower. Our paper contributes to the literature of retrospective voting and demonstrates that voters hold leaders accountable for their (mis-)handling of negative shocks.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/metaarxiv/sxajv/" target="_blank">The COVID-19 Pandemic and US Presidential Elections</a>
</div></li>
<li><strong>Anti-Intellectualism and the Mass Public’s Response to the Covid-19 Pandemic</strong> -
<div>
Anti-intellectualism – the generalized distrust of experts and intellectuals – is an important concept in explaining the public’s engagement with advice from scientists and experts. We ask whether it has shaped the mass public’s response to COVID-19. We provide evidence of a consistent connection between anti-intellectualism and COVID-19 risk perceptions, social distancing, mask usage, misperceptions, and information search behaviour using a representative survey of 27,615 Canadians conducted from March to July 2020. We exploit a panel-component of our design (N=4,910) to mitigate the threat of endogeneity and strongly link anti-intellectualism and within-respondent change in mask usage. Finally, we provide experimental evidence of anti-intellectualism’s importance in information search behaviour with two conjoint studies (N~2,500) that show respondents ’ preferences for COVID-19 news and COVID-19 information from experts dissipate among those with higher levels of anti-intellectual sentiment. Anti-intellectualism poses a fundamental challenge in maintaining and increasing public compliance with expert-guided COVID-19 health directives.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/agm57/" target="_blank">Anti-Intellectualism and the Mass Public’s Response to the Covid-19 Pandemic</a>
</div></li>
<li><strong>Digital interventions to mitigate the negative impact of the COVID-19 pandemic on public mental health: a rapid meta-review</strong> -
<div>
Background: Digital interventions may be used to mitigate psychosocial consequences of the COVID-19 pandemic but evidence-based recommendations are lacking. The aim of this rapid meta-review was to investigate the theoretical base, user perspective, safety, effectiveness, and cost effectiveness of digital interventions in public mental health provision (i.e. mental health promotion, prevention of, and treatment for mental disorder). Methods: A rapid meta-review was conducted. MEDLINE, PsychINFO, and CENTRAL databases were searched on May 11, 2020. Study inclusion criteria were broad and considered systematic reviews that investigated digital tools for health promotion, prevention, or treatment of mental health conditions likely affected by the COVID-19 pandemic. Findings: We identified 813 reviews of which 82 met inclusion criteria. Overall, there is good evidence on the usability, safety, acceptance/satisfaction, and effectiveness of eHealth interventions while evidence on mHealth apps is promising, especially if social components (e.g. blended care) and strategies to promote adherence are incorporated. Although most digital interventions focus on the prevention or treatment of mental disorders, there is some evidence on mental health promotion. However, evidence on long-term clinical effects, process quality, and cost-effectiveness is very limited. Interpretation: Accumulating evidence suggests negative effects of the COVID-19 pandemic on public mental health. There is evidence that digital interventions are particularly suited to mitigating psychosocial consequences at the population level. Decision-makers should develop digital strategies for continued mental health care and the development and implementation of mental health promotion and prevention programs in times of quarantine and social distancing.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/uvc78/" target="_blank">Digital interventions to mitigate the negative impact of the COVID-19 pandemic on public mental health: a rapid meta-review</a>
</div></li>
<li><strong>Asymptomatic Employee Screening for SARS-CoV-2: Implementation of and Reactions to an Employer-Based Testing Program.</strong> -
<div>
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Introduction. Asymptomatic testing for SARS-CoV-2 among healthcare workers or other essential personnel could remove infected carriers from the workforce, decreasing chances for transmission and workplace outbreaks. Results from one-time testing programs have been reported but data regarding longitudinal testing, including information about employees reactions to such programs, is not readily available. Methods. To identify asymptomatic carriers of SARS-CoV-2, we implemented a longitudinal screening program for critical on-site employees within our research institute in early April 2020. We conducted a survey of both on-site employees and those working from home in order to measure their reactions to the testing program. Statistical analysis of the survey was conducted with general linear regression and Pearsons Chi-Square tests. Results. Despite an ongoing high community prevalence rate of COVID-19, to date only two asymptomatic employees tested positive out of 1050 tests run during 7 months of the program. However, 12 symptomatic employees not participating in the program have tested positive. The employee survey was completed by 132/306 (43%) employees, with 93% agreeing that asymptomatic employee screening led to a better and safer working environment and 75% agreeing with on-site public health measures to help contain the virus, but only 58% feeling COVID-19 was a serious threat to their health. Conclusion. Our results suggest that a longitudinal asymptomatic employee screening program for SARS-CoV-2 can be accepted by employees and can be used to maintain the health of the workforce, potentially keeping positivity rates below community levels in the face of the ongoing COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.06.20227314v1" target="_blank">Asymptomatic Employee Screening for SARS-CoV-2: Implementation of and Reactions to an Employer-Based Testing Program.</a>
</div></li>
<li><strong>Challenges of Deep Learning Methods for COVID-19 Detection Using Public Datasets</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A large number of studies in the past months have proposed deep learning-based Artificial Intelligence (AI) tools for automated detection of COVID-19 using publicly available datasets of Chest X-rays (CXRs) or CT scans for training and evaluation. Most of these studies report high accuracy when classifying COVID-19 patients from normal or other commonly occurring pneumonia cases. However, these results are often obtained on cross-validation studies without an independent test set coming from a separate dataset and have biases such as the two classes to be predicted come from two completely different datasets. In this work, we investigate potential overfitting and biases in such studies by designing different experimental setups within the available public data constraints and highlight the challenges and limitations of developing deep learning models with such datasets. We propose a deep learning architecture for COVID-19 classification that combines two very popular classification networks, ResNet and Xception, and use it to carry out the experiments to investigate challenges and limitations. The results show that the deep learning models can overestimate their performance due to biases in the experimental design and overfitting to the training dataset. We compare the proposed architecture to state-of-the-art methods utilizing an independent test set for evaluation, where some of the identified bias and overfitting issues are reduced. Although our proposed deep learning architecture gives the best performance with our best possible setup, we highlight the challenges in comparing and interpreting various deep learning algorithms9 results. While the deep learning-based methods using chest imaging data show promise in being helpful for clinical management and triage of COVID-19 patients, our experiments suggest that a larger, more comprehensive database with less bias is necessary for developing tools applicable in real clinical settings.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.07.20227504v1" target="_blank">Challenges of Deep Learning Methods for COVID-19 Detection Using Public Datasets</a>
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<li><strong>ConceptWAS: a high-throughput method for early identification of COVID-19 presenting symptoms</strong> -
<div>
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Objective: Identifying symptoms highly specific to COVID-19 would improve the clinical and public health response to infectious outbreaks. Here, we describe a high-throughput approach - Concept-Wide Association Study (ConceptWAS) that systematically scans a disease9s clinical manifestations from clinical notes. We used this method to identify symptoms specific to COVID-19 early in the course of the pandemic. Methods: Using the Vanderbilt University Medical Center (VUMC) EHR, we parsed clinical notes through a natural language processing pipeline to extract clinical concepts. We examined the difference in concepts derived from the notes of COVID-19-positive and COVID-19-negative patients on the PCR testing date. We performed ConceptWAS using the cumulative data every two weeks for early identifying specific COVID-19 symptoms. Results: We processed 87,753 notes 19,692 patients (1,483 COVID-19-positive) subjected to COVID-19 PCR testing between March 8, 2020, and May 27, 2020. We found 68 clinical concepts significantly associated with COVID-19. We identified symptoms associated with increasing risk of COVID-19, including “absent sense of smell” (odds ratio [OR] = 4.97, 95% confidence interval [CI] = 3.21-7.50), “fever” (OR = 1.43, 95% CI = 1.28-1.59), “with cough fever” (OR = 2.29, 95% CI = 1.75-2.96), and “ageusia” (OR = 5.18, 95% CI = 3.02-8.58). Using ConceptWAS, we were able to detect loss sense of smell or taste three weeks prior to their inclusion as symptoms of the disease by the Centers for Disease Control and Prevention (CDC). Conclusion: ConceptWAS is a high-throughput approach for exploring specific symptoms of a disease like COVID-19, with a promise for enabling EHR-powered early disease manifestations identification.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.06.20227165v1" target="_blank">ConceptWAS: a high-throughput method for early identification of COVID-19 presenting symptoms</a>
</div></li>
<li><strong>COVID-19 detection on IBM quantum computer with classical-quantum transfer learning</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Diagnose the infected patient as soon as possible in the coronavirus 2019 (COVID-19) outbreak which is declared as a pandemic by the world health organization (WHO) is extremely important. Experts recommend CT imaging as a diagnostic tool because of the weak points of the nucleic acid amplification test (NAAT). In this study, the detection of COVID-19 from CT images, which give the most accurate response in a short time, was investigated in the classical computer and firstly in quantum computers. Using the quantum transfer learning method, we experimentally perform COVID-19 detection in different quantum real processors (IBMQx2, IBMQ London and IBMQ-Rome) of IBM, as well as in different simulators (Pennylane, Qiskit-Aer and Cirq). By using a small number of data sets such as 126 COVID-19 and 100 Normal CT images, we obtained a positive or negative classification of COVID-19 with 90% success in classical computers, while we achieved a high success rate of 94-100% in quantum computers. Also, according to the results obtained, machine learning process in classical computers requiring more processors and time than quantum computers can be realized in a very short time with a very small quantum processor such as 4 qubits in quantum computers. If the size of the data set is small; Due to the superior properties of quantum, it is seen that according to the classification of COVID-19 and Normal, in terms of machine learning, quantum computers seem to outperform traditional computers.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.07.20227306v1" target="_blank">COVID-19 detection on IBM quantum computer with classical-quantum transfer learning</a>
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<li><strong>Synthetic Reproduction and Augmentation of COVID-19 Case Reporting Data by Agent-Based Simulation</strong> -
<div>
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We generate synthetic data documenting COVID-19 cases in Austria by the means of an agent-based simulation model. The model simulates the transmission of the SARS-CoV-2 virus in a statistical replica of the population and reproduces typical patient pathways on an individual basis while simultaneously integrating historical data on the implementation and expiration of population-wide countermeasures. The resulting data semantically and statistically aligns with an official epidemiological case reporting data set and provides an easily accessible, consistent and augmented alternative. Our synthetic data set provides additional insight into the spread of the epidemic by synthesizing information that cannot be recorded in reality.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.07.20227462v1" target="_blank">Synthetic Reproduction and Augmentation of COVID-19 Case Reporting Data by Agent-Based Simulation</a>
</div></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1> <h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul> <ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: FSD201;   Drug: Placebo<br/><b>Sponsor</b>:   FSD Pharma, Inc.<br/><b>Not yet recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: FSD201;   Drug: Placebo<br/><b>Sponsor</b>:   FSD Pharma, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Probiotics in Reducing Symptoms of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: Probiotics (2 strains 10x10^9 UFC);   Dietary Supplement: Placebo (potato starch and magnesium stearate)<br/><b>Sponsors</b>:   Centre de recherche du Centre hospitalier universitaire de Sherbrooke;   Lallemand Health Solutions<br/><b>Not yet recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Probiotics in Reducing Symptoms of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: Probiotics (2 strains 10x10^9 UFC);   Dietary Supplement: Placebo (potato starch and magnesium stearate)<br/><b>Sponsors</b>:   Centre de recherche du Centre hospitalier universitaire de Sherbrooke;   Lallemand Health Solutions<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVI-VAC;   Other: Placebo<br/><b>Sponsor</b>:   Codagenix, Inc<br/><b>Not yet recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVI-VAC;   Other: Placebo<br/><b>Sponsor</b>:   Codagenix, Inc<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Niclosamide in Moderate Hospitalized Coronavirus-19 (COVID-19) Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Niclosamide;   Drug: Placebo<br/><b>Sponsor</b>:   ANA Therapeutics<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Mouthwash in Reducing Salivary Carriage of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: 0.5% Povidone Iodine;   Drug: 0.12% Chlorhexidine Gluconate Mouth Rinse;   Drug: 1% Hydrogen Peroxide;   Drug: 0.9% Normal Saline<br/><b>Sponsor</b>:   Ohio State University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACTION ON COVID-19: A Study to Test Whether BI 764198 Helps Lung Health of People Hospitalised With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: BI 764198;   Drug: Placebo<br/><b>Sponsor</b>:   Boehringer Ingelheim<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comparison of Two Different Doses of Bemiparin in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Bemiparin sodium<br/><b>Sponsor</b>:   Clinica Universidad de Navarra, Universidad de Navarra<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An Outpatient Study Investigating Non-prescription Treatments for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Other: chlorine dioxide;   Dietary Supplement: zinc acetate;   Drug: Famotidine;   Other: placebo;   Dietary Supplement: lactoferrin, green tea extract<br/><b>Sponsor</b>:   Profact, Inc.<br/><b>Not yet recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An Outpatient Study Investigating Non-prescription Treatments for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Other: chlorine dioxide;   Dietary Supplement: zinc acetate;   Drug: Famotidine;   Other: placebo;   Dietary Supplement: lactoferrin, green tea extract<br/><b>Sponsor</b>:   Profact, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study Evaluating the Efficacy and Safety of CKD-314 (Nafabelltan) in Hospitalized Adult Patients Diagnosed With COVID-19 Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Nafamostat Mesilate<br/><b>Sponsor</b>:   Chong Kun Dang Pharmaceutical<br/><b>Recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study Evaluating the Efficacy and Safety of CKD-314 (Nafabelltan) in Hospitalized Adult Patients Diagnosed With COVID-19 Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Nafamostat Mesilate<br/><b>Sponsor</b>:   Chong Kun Dang Pharmaceutical<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Angiotensin 1-7 as a Therapy in the Treatment of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Angiotensin 1-7<br/><b>Sponsors</b>:   Rambam Health Care Campus;   Constant Therapeutics<br/><b>Not yet recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Angiotensin 1-7 as a Therapy in the Treatment of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Angiotensin 1-7<br/><b>Sponsors</b>:   Rambam Health Care Campus;   Constant Therapeutics<br/><b>Not yet recruiting</b></p></li>
@ -169,6 +155,10 @@ We generate synthetic data documenting COVID-19 cases in Austria by the means of
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Clarithromycin 500mg;   Drug: Azithromycin;   Drug: Placebo<br/><b>Sponsor</b>:   South Valley University<br/><b>Completed</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Clarithromycin 500mg;   Drug: Azithromycin;   Drug: Placebo<br/><b>Sponsor</b>:   South Valley University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: CNM-ZnAg;   Drug: Placebo<br/><b>Sponsors</b>:   Clene Nanomedicine;   ICL Pharma;   Azidus Brazil<br/><b>Not yet recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: CNM-ZnAg;   Drug: Placebo<br/><b>Sponsors</b>:   Clene Nanomedicine;   ICL Pharma;   Azidus Brazil<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Two Hyperimmune Equine Anti Sars-CoV-2 in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: Administration of Equine immunoglobulin anti SARS-CoV-2<br/><b>Sponsors</b>:   Caja Costarricense de Seguro Social;   Universidad de Costa Rica;   Ministry of Health Costa Rica<br/><b>Recruiting</b></p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Two Hyperimmune Equine Anti Sars-CoV-2 in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: Administration of Equine immunoglobulin anti SARS-CoV-2<br/><b>Sponsors</b>:   Caja Costarricense de Seguro Social;   Universidad de Costa Rica;   Ministry of Health Costa Rica<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mesenchymal Stem Cells in Patients Diagnosed With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: MSC;   Other: Control<br/><b>Sponsors</b>:   Hospital Reg. Lic. Adolfo Lopez Mateos;   Instituto de Terapia Celular: ITC<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Diagnostic Performance Evaluation of a Novel SARS-CoV-2 (COVID-19) Antigen Detection Test</strong> - <b>Conditions</b>:   Covid19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Diagnostic Test: RT-qPCR test;   Diagnostic Test: COVID-VIRO® test<br/><b>Sponsor</b>:   Centre Hospitalier Régional d’Orléans<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>plasmApuane CoV-2 : Efficacy and Safety of Immune Covid-19 Plasma in Covid-19 Pneumonia in Non ITU Patients</strong> - <b>Condition</b>:   Covid-19 Pneumonia<br/><b>Intervention</b>:   Biological: immune plasma<br/><b>Sponsor</b>:   Azienda USL Toscana Nord Ovest<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the Efficacy of Xylitol Nasal Spray Against SARS-CoV-2</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Nasal Spray<br/><b>Sponsors</b>:   Larkin Community Hospital;   Ferrer Medical Innovations;   Xlear<br/><b>Recruiting</b></p></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1> <h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul> <ul>

93
archive-daily-dose/11 November, 2020.html
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1> <h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1> <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
@ -34,22 +34,22 @@
<ul> <ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple’s “One More Thing” | Post-Event Megathread</strong></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple’s “One More Thing” | Post-Event Megathread</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple unveils M1, its first system-on-a-chip for portable Mac computers</strong></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple unveils M1, its first system-on-a-chip for portable Mac computers</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple Ends Today’s Mac Event With Return of Totally Jealous PC Guy</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple will release macOS Big Sur on November 12th</strong></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple will release macOS Big Sur on November 12th</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple Store is down ahead of ‘One More Thing Mac’ event</strong></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple has iFixit tools in their lab</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New MacBook Air Announced as First Apple Silicon Mac With M1 Chip</strong></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-hacker-news">From Hacker News</h1> <h1 data-aos="fade-right" id="from-hacker-news">From Hacker News</h1>
<ul> <ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple unveils M1, its first system-on-a-chip for portable Mac computers</strong> - <a href="https://news.ycombinator.com/item?id=25049079">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How to get root on Ubuntu 20.04 by pretending nobody’s /home</strong> - <a href="https://news.ycombinator.com/item?id=25053238">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How to get root on Ubuntu 20.04 by pretending nobody’s /home</strong> - <a href="https://news.ycombinator.com/item?id=25053238">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>On Apple’s Piss-Poor Documentation</strong> - <a href="https://news.ycombinator.com/item?id=25046691">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cell Signaling Technologies – Detailed 3D model of human cells</strong> - <a href="https://news.ycombinator.com/item?id=25055908">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Introducing the next generation of Mac</strong> - <a href="https://news.ycombinator.com/item?id=25049528">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Snood Bloober is an open-source reverse-engineered Sound Blaster 1.0 clone</strong> - <a href="https://news.ycombinator.com/item?id=25029727">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>.NET 5.0</strong> - <a href="https://news.ycombinator.com/item?id=25047409">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A crop of startups are trying to make for-profit local news work</strong> - <a href="https://news.ycombinator.com/item?id=25056061">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>YubiKey Biometric Security Key</strong> - <a href="https://news.ycombinator.com/item?id=25053644">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Using Rust to Scale Elixir for 11M Concurrent Users (2019)</strong> - <a href="https://news.ycombinator.com/item?id=25053553">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Lonely Work of Moderating Hacker News (2019)</strong> - <a href="https://news.ycombinator.com/item?id=25048415">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple unveils M1, its first system-on-a-chip for portable Mac computers</strong> - <a href="https://news.ycombinator.com/item?id=25049079">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>InfluxDB 2.0 Is Out</strong> - <a href="https://news.ycombinator.com/item?id=25053812">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The election of the doge</strong> - <a href="https://news.ycombinator.com/item?id=25039470">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Origins of the youtube-dl project</strong> - <a href="https://news.ycombinator.com/item?id=25047818">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Drug Themes in Science Fiction, by Robert Silverberg (1974) [pdf]</strong> - <a href="https://news.ycombinator.com/item?id=25055991">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Using Rust to Scale Elixir for 11M Concurrent Users</strong> - <a href="https://news.ycombinator.com/item?id=25053553">Comments</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Notes for courses taken at Harvard (2015-2019)</strong> - <a href="https://news.ycombinator.com/item?id=25055267">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Python Concurrency From the Ground Up (2015) [video]</strong> - <a href="https://news.ycombinator.com/item?id=25033078">Comments</a></p></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1> <h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul> <ul>
@ -61,35 +61,35 @@
</ul> </ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1> <h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul> <ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Full auction for IPL 2021</strong> - It is understood that BCCI has plans to add a ninth team to the fold</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australian men’s team to wear Indigenous jersey in T20s against India</strong> - It is aimed at recognising and encouraging the Indigenous Australians’ role in cricket</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Morikawa not intimidated by Masters challenge</strong> - PGA Championship winner says he has done his prep work</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>It was mentally tough in bio-bubble: Ganguly thanks players for commitment to IPL success</strong> - Following months of deliberation, it was shifted to the UAE venues of Dubai, Sharjah and Abu Dhabi and was conducted in a bio-secure environment.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lovlina fighting to remain focused</strong> - Stays afloat in the face of a string of adversities</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2020 | I should’ve sacrificed my wicket for Surya: Rohit</strong> - Yadav, who accumulated 480 runs this season averaging 40 with a strike rate of 145, said he didn’t mind the sacrifice as he knew the skipper would lead the team through.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Six-time champion Marquez not to return before 2021</strong> - He has been sidelined since crashing out of the Spanish Grand Prix on July 19</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>West Indies cricket squad sanctioned for breaching isolation rules</strong> - New Zealand’s Ministry of Health said CCTV footage from the team’s Christchurch hotel showed players mingling in hallways and sharing food in violation of managed isolation regulations.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prannoy working on improving his fitness</strong> - The shuttler aims to qualify for the Olympic Games and better his ranking</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>China’s Chen Meng claims ITTF Women’s World Cup title</strong> - Chen’s victory at the bio-secure Weihai Nanhai Olympic Center made her the first winner of the ITTF’s #RESTART series and also took her tally of senior singles titles to 19.</p></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1> <h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul> <ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India gifts 20 horses, 10 mine detection dogs to Bangladesh Army</strong> - India on Tuesday gifted 20 fully trained military horses and 10 mine detection dogs to the Bangladesh Army. These were trained by the Remount and Vete</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Meghalaya govt encouraging illegal coal mining, says NGO</strong> - Accusation follows scathing attack by Opposition Congress in Assembly over the issue</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Punjab recruits 482 new medical officers amid COVID-19 pandemic</strong> - Move to meet staff shortages, provide employment</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Class 10 J&amp;K board exams begin in Kashmir</strong> - The examination centres have been almost doubled from the previous year to ensure adherence to social distancing norms.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bihar Assembly polls | NDA overcomes stiff challenge to retain power in Bihar</strong> - The ruling coalition won 125 seats in the 243-member State Assembly against 110 clinched by the Opposition Grand Alliance.</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bihar Assembly election | ‘We are happy with LJP’s poll impact,’ says Chirag Paswan</strong> - The Lok Janshakti Party won just one seat of Manihari in Begusarai district, but it affected the prospects of the NDA alliance partner JD(U) in nearly 20 seats.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Legacy war in Nandigram as Trinamool, its Minister hold separate rallies</strong> - In a veiled attack on party, Suvendu Adhikari says they will meet “on the battlefield”</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Data | Bihar Assembly election 2020: A matter of alliance cohesion</strong> - The Mahagathbandhan fell short due to the poor performance of the Congress in the seats it contested</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBI books Best Foods, others in bank fraud</strong> - Bank consortium cheated of ₹1,006.46 crore</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PM Modi to co-chair virtual India-ASEAN summit on Thursday</strong> - MEA said the summit will review the status of ASEAN-India strategic partnership.</p></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1> <h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul> <ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nagorno-Karabakh: Russia deploys peacekeeping troops to region</strong> - Hundreds of troops are deployed after Armenia and Azerbaijan agreed to end six weeks of war.</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nagorno-Karabakh: Russia deploys peacekeeping troops to region</strong> - Hundreds of troops are deployed after Armenia and Azerbaijan agreed to end six weeks of war.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Denmark mink cull: Government admits culling had no legal basis</strong> - PM Mette Frederiksen apologises for going ahead with the mass cull of mink without new legislation.</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Denmark mink cull: Government admits culling had no legal basis</strong> - PM Mette Frederiksen apologises for going ahead with the mass cull of mink without new legislation.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Catholic Church abuse: Vatican defends handling of McCarrick case</strong> - Theodore McCarrick was expelled from the priesthood after an inquiry found him guilty of sex abuse.</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Catholic Church abuse: Vatican defends handling of McCarrick case</strong> - Theodore McCarrick was expelled from the priesthood after an inquiry found him guilty of sex abuse.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Russia resists lockdown and pins hopes on vaccine</strong> - An ice rink is being used to treat Covid patients as Russia hopes its Sputnik V vaccine will resolve the crisis.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Turkish Germans raise new Covid vaccine hopes</strong> - A husband and wife from Turkish immigrant families spearhead a vaccine breakthrough.</p></li> <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Turkish Germans raise new Covid vaccine hopes</strong> - A husband and wife from Turkish immigrant families spearhead a vaccine breakthrough.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Norwich Cathedral given Edith Cavell’s ‘last World War One letter’</strong> - Edith Cavell wrote to her mother just days before she was arrested and shot during World War One.</p></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1> <h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul> <ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Biden tapped several Big Tech staffers for his transition team</strong> - A number of Obama staffers got tech jobs during Trump’s term. Now they’re back. - <a href="https://arstechnica.com/?p=1722402">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>England faces a proper “argy-bargy” in Pennyworth S2 trailer</strong> - S1 now available for streaming on Amazon Prime, so it’s the perfect time to catch up. - <a href="https://arstechnica.com/?p=1722348">link</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>England faces a proper “argy-bargy” in Pennyworth S2 trailer</strong> - S1 now available for streaming on Amazon Prime, so it’s the perfect time to catch up. - <a href="https://arstechnica.com/?p=1722348">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dutch scientists reconstruct spread of coronavirus through mink farms</strong> - So far, however, no evidence of dangerous mutations being selected in mink. - <a href="https://arstechnica.com/?p=1722350">link</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dutch scientists reconstruct spread of coronavirus through mink farms</strong> - So far, however, no evidence of dangerous mutations being selected in mink. - <a href="https://arstechnica.com/?p=1722350">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ubuntu fixes bugs that standard users could use to become root</strong> - A handful of commands was all it took for untrusted users to become all-powerful. - <a href="https://arstechnica.com/?p=1722318">link</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ubuntu fixes bugs that standard users could use to become root</strong> - A handful of commands was all it took for untrusted users to become all-powerful. - <a href="https://arstechnica.com/?p=1722318">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>James Corden is a snarky AI that might take out humanity in Superintelligence</strong> - Director Ben Falcone opted to release the film on HBO Max even before the pandemic. - <a href="https://arstechnica.com/?p=1722240">link</a></p></li> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>James Corden is a snarky AI that might take out humanity in Superintelligence</strong> - Director Ben Falcone opted to release the film on HBO Max even before the pandemic. - <a href="https://arstechnica.com/?p=1722240">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Microsoft engineer gets nine years for stealing $10M from Microsoft</strong> - The defendant tried—and failed—to use bitcoin to cover his tracks. - <a href="https://arstechnica.com/?p=1721845">link</a></p></li>
</ul> </ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1> <h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul> <ul>
@ -109,57 +109,30 @@ Just add the NSFW tag.
</div> </div>
<!-- SC_ON --> <!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/honolulu_oahu_mod"> /u/honolulu_oahu_mod </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jrjl9g/okay_fred_shaggy_and_daphne_can_you_name_an/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jrjl9g/okay_fred_shaggy_and_daphne_can_you_name_an/">[comments]</a></span></p></li> <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/honolulu_oahu_mod"> /u/honolulu_oahu_mod </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jrjl9g/okay_fred_shaggy_and_daphne_can_you_name_an/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jrjl9g/okay_fred_shaggy_and_daphne_can_you_name_an/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Jewish pilot and Chinese pilot are flying together for the 1st time.</strong> - <!-- SC_OFF --></p> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>My girlfriend dressed up as a policewoman and told me I was under arrest on suspicion of being good in bed.</strong> - <!-- SC_OFF --></p>
<div class="md"> <div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
An hour into the flight, the Jewish pilot says to his Chinese counterpart “I don’t like the Chinese.” After 2 minutes all charges were dropped due to a lack of evidence.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Stunned, the Chinese pilot replies “Why don’t you like the Chinese?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Well” says the Jew, “the Chinese bombed Pearl Harbor.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Even more stunned, he replies ”The Chinese didn’t bomb Pearl Harbor! It was the Japanese!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Well, Chinese, Japanese, Vietnamese, they’re all the same to me.” says the Jew.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Chinese pilot is seething at this, and after a while he turns to his Jewish counterpart to say “I don’t like the Jews.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“What?” asks the Jew. “Why don’t you like Jews?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Well” he says, “The Jews sank the Titanic.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Jewish pilot scoffs at this, “The Jews didn’t sink the Titanic! An Iceberg sank the Titanic!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Well” he replies, “Iceberg, Goldberg, Rosenberg, they’re all the same to me.”
</p> </p>
</div> </div>
<!-- SC_ON --> <!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/-ChipButty-"> /u/-ChipButty- </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jrdmu9/a_jewish_pilot_and_chinese_pilot_are_flying/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jrdmu9/a_jewish_pilot_and_chinese_pilot_are_flying/">[comments]</a></span></p></li> <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/F12BIXXH"> /u/F12BIXXH </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js14zi/my_girlfriend_dressed_up_as_a_policewoman_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js14zi/my_girlfriend_dressed_up_as_a_policewoman_and/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why do vampires usually pull out during sex?</strong> - <!-- SC_OFF --></p> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What is the difference between a literalist and a kleptomaniac?</strong> - <!-- SC_OFF --></p>
<div class="md"> <div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
They can’t come inside without an invitation. A comma. A literalist takes everything literally. A kleptomaniac takes everything, literally.
</p> </p>
</div> </div>
<!-- SC_ON --> <!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/RoosterShield"> /u/RoosterShield </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jro29r/why_do_vampires_usually_pull_out_during_sex/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jro29r/why_do_vampires_usually_pull_out_during_sex/">[comments]</a></span></p></li> <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Pizzareno"> /u/Pizzareno </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js29m4/what_is_the_difference_between_a_literalist_and_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js29m4/what_is_the_difference_between_a_literalist_and_a/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What should we do with people who rely on government handouts, but refuse to work?</strong> - <!-- SC_OFF --></p> <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How many clickbait articles does it take to change a lightbulb?</strong> - <!-- SC_OFF --></p>
<div class="md"> <div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Kick them out of Congress The answer will shock you…
</p> </p>
</div> </div>
<!-- SC_ON --> <!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/VERBERD"> /u/VERBERD </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jrwhb6/what_should_we_do_with_people_who_rely_on/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jrwhb6/what_should_we_do_with_people_who_rely_on/">[comments]</a></span></p></li> <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/wcslater"> /u/wcslater </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js3nfy/how_many_clickbait_articles_does_it_take_to/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js3nfy/how_many_clickbait_articles_does_it_take_to/">[comments]</a></span></p></li>
</ul> </ul>

7
main.py
View File

@ -21,7 +21,7 @@ ConvertToHTML = True
title = date.today().strftime('%d %B, %Y') title = date.today().strftime('%d %B, %Y')
og_title = title og_title = title
feed_configuration = ['feeds.ini','covid.ini'] feed_configuration = ['feeds.ini','covid.ini']
archive_configuration = {"feeds.ini":{"id":"daily-dose-list","folder":"archive-daily-dose",'title':"Daily-Dose"},"covid.ini":{"id":"covid-19-list","folder":"archive-covid-19","title":"Covid-19 Sentry"}} archive_configuration = {"feeds.ini":{"id":"daily-dose-list","folder":"archive-daily-dose",'title':"Daily-Dose","hide_overflow":True},"covid.ini":{"id":"covid-19-list","folder":"archive-covid-19","title":"Covid-19 Sentry","hide_overflow":False}}
update_archive = True update_archive = True
############# #############
@ -235,6 +235,11 @@ for config in feed_configuration:
custom_css = soup.new_tag('link',href=str("../"+html_stylesheet),rel='stylesheet') custom_css = soup.new_tag('link',href=str("../"+html_stylesheet),rel='stylesheet')
soup.head.append(custom_css) soup.head.append(custom_css)
if archive_configuration[config]["hide_overflow"]:
a = soup.new_tag('style')
a.string = "*{overflow-x:hidden;}"
soup.head.append(a)
if animations: if animations:
aos_css = soup.new_tag('link',href='https://unpkg.com/aos@2.3.1/dist/aos.css',rel='stylesheet') aos_css = soup.new_tag('link',href='https://unpkg.com/aos@2.3.1/dist/aos.css',rel='stylesheet')
soup.head.append(aos_css) soup.head.append(aos_css)