-Introduction. Asymptomatic testing for SARS-CoV-2 among healthcare workers or other essential personnel could remove infected carriers from the workforce, decreasing chances for transmission and workplace outbreaks. Results from one-time testing programs have been reported but data regarding longitudinal testing, including information about employees reactions to such programs, is not readily available. Methods. To identify asymptomatic carriers of SARS-CoV-2, we implemented a longitudinal screening program for critical on-site employees within our research institute in early April 2020. We conducted a survey of both on-site employees and those working from home in order to measure their reactions to the testing program. Statistical analysis of the survey was conducted with general linear regression and Pearsons Chi-Square tests. Results. Despite an ongoing high community prevalence rate of COVID-19, to date only two asymptomatic employees tested positive out of 1050 tests run during 7 months of the program. However, 12 symptomatic employees not participating in the program have tested positive. The employee survey was completed by 132/306 (43%) employees, with 93% agreeing that asymptomatic employee screening led to a better and safer working environment and 75% agreeing with on-site public health measures to help contain the virus, but only 58% feeling COVID-19 was a serious threat to their health. Conclusion. Our results suggest that a longitudinal asymptomatic employee screening program for SARS-CoV-2 can be accepted by employees and can be used to maintain the health of the workforce, potentially keeping positivity rates below community levels in the face of the ongoing COVID-19 pandemic. -
--A large number of studies in the past months have proposed deep learning-based Artificial Intelligence (AI) tools for automated detection of COVID-19 using publicly available datasets of Chest X-rays (CXRs) or CT scans for training and evaluation. Most of these studies report high accuracy when classifying COVID-19 patients from normal or other commonly occurring pneumonia cases. However, these results are often obtained on cross-validation studies without an independent test set coming from a separate dataset and have biases such as the two classes to be predicted come from two completely different datasets. In this work, we investigate potential overfitting and biases in such studies by designing different experimental setups within the available public data constraints and highlight the challenges and limitations of developing deep learning models with such datasets. We propose a deep learning architecture for COVID-19 classification that combines two very popular classification networks, ResNet and Xception, and use it to carry out the experiments to investigate challenges and limitations. The results show that the deep learning models can overestimate their performance due to biases in the experimental design and overfitting to the training dataset. We compare the proposed architecture to state-of-the-art methods utilizing an independent test set for evaluation, where some of the identified bias and overfitting issues are reduced. Although our proposed deep learning architecture gives the best performance with our best possible setup, we highlight the challenges in comparing and interpreting various deep learning algorithms9 results. While the deep learning-based methods using chest imaging data show promise in being helpful for clinical management and triage of COVID-19 patients, our experiments suggest that a larger, more comprehensive database with less bias is necessary for developing tools applicable in real clinical settings. -
--Objective: Identifying symptoms highly specific to COVID-19 would improve the clinical and public health response to infectious outbreaks. Here, we describe a high-throughput approach - Concept-Wide Association Study (ConceptWAS) that systematically scans a disease9s clinical manifestations from clinical notes. We used this method to identify symptoms specific to COVID-19 early in the course of the pandemic. Methods: Using the Vanderbilt University Medical Center (VUMC) EHR, we parsed clinical notes through a natural language processing pipeline to extract clinical concepts. We examined the difference in concepts derived from the notes of COVID-19-positive and COVID-19-negative patients on the PCR testing date. We performed ConceptWAS using the cumulative data every two weeks for early identifying specific COVID-19 symptoms. Results: We processed 87,753 notes 19,692 patients (1,483 COVID-19-positive) subjected to COVID-19 PCR testing between March 8, 2020, and May 27, 2020. We found 68 clinical concepts significantly associated with COVID-19. We identified symptoms associated with increasing risk of COVID-19, including âabsent sense of smellâ (odds ratio [OR] = 4.97, 95% confidence interval [CI] = 3.21-7.50), âfeverâ (OR = 1.43, 95% CI = 1.28-1.59), âwith cough feverâ (OR = 2.29, 95% CI = 1.75-2.96), and âageusiaâ (OR = 5.18, 95% CI = 3.02-8.58). Using ConceptWAS, we were able to detect loss sense of smell or taste three weeks prior to their inclusion as symptoms of the disease by the Centers for Disease Control and Prevention (CDC). Conclusion: ConceptWAS is a high-throughput approach for exploring specific symptoms of a disease like COVID-19, with a promise for enabling EHR-powered early disease manifestations identification. -
--Diagnose the infected patient as soon as possible in the coronavirus 2019 (COVID-19) outbreak which is declared as a pandemic by the world health organization (WHO) is extremely important. Experts recommend CT imaging as a diagnostic tool because of the weak points of the nucleic acid amplification test (NAAT). In this study, the detection of COVID-19 from CT images, which give the most accurate response in a short time, was investigated in the classical computer and firstly in quantum computers. Using the quantum transfer learning method, we experimentally perform COVID-19 detection in different quantum real processors (IBMQx2, IBMQ London and IBMQ-Rome) of IBM, as well as in different simulators (Pennylane, Qiskit-Aer and Cirq). By using a small number of data sets such as 126 COVID-19 and 100 Normal CT images, we obtained a positive or negative classification of COVID-19 with 90% success in classical computers, while we achieved a high success rate of 94-100% in quantum computers. Also, according to the results obtained, machine learning process in classical computers requiring more processors and time than quantum computers can be realized in a very short time with a very small quantum processor such as 4 qubits in quantum computers. If the size of the data set is small; Due to the superior properties of quantum, it is seen that according to the classification of COVID-19 and Normal, in terms of machine learning, quantum computers seem to outperform traditional computers. -
--We generate synthetic data documenting COVID-19 cases in Austria by the means of an agent-based simulation model. The model simulates the transmission of the SARS-CoV-2 virus in a statistical replica of the population and reproduces typical patient pathways on an individual basis while simultaneously integrating historical data on the implementation and expiration of population-wide countermeasures. The resulting data semantically and statistically aligns with an official epidemiological case reporting data set and provides an easily accessible, consistent and augmented alternative. Our synthetic data set provides additional insight into the spread of the epidemic by synthesizing information that cannot be recorded in reality. -
-Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19 - Condition: Â COVID-19
Interventions: Â Drug:Â FSD201; Â Drug:Â Placebo
Sponsor:  FSD Pharma, Inc.
Not yet recruiting
Efficacy of Probiotics in Reducing Symptoms of COVID-19 - Condition: Â COVID-19
Interventions: Â Dietary Supplement: Probiotics (2 strains 10x10^9 UFC); Â Dietary Supplement: Placebo (potato starch and magnesium stearate)
Sponsors:  Centre de recherche du Centre hospitalier universitaire de Sherbrooke;  Lallemand Health Solutions
Not yet recruiting
Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19 - Condition: Â COVID-19
Interventions: Â Biological:Â COVI-VAC; Â Other:Â Placebo
Sponsor:  Codagenix, Inc
Not yet recruiting
Study of Niclosamide in Moderate Hospitalized Coronavirus-19 (COVID-19) Patients - Condition: Â COVID-19
Interventions: Â Drug:Â Niclosamide; Â Drug:Â Placebo
Sponsor: Â ANAÂ Therapeutics
Recruiting
Efficacy of Mouthwash in Reducing Salivary Carriage of COVID-19 - Condition: Â COVID-19
Interventions:  Drug: 0.5% Povidone Iodine;  Drug: 0.12% Chlorhexidine Gluconate Mouth Rinse;  Drug: 1% Hydrogen Peroxide;  Drug: 0.9% Normal Saline
Sponsor:  Ohio State University
Recruiting
ACTION ON COVID-19: A Study to Test Whether BI 764198 Helps Lung Health of People Hospitalised With COVID-19 - Condition: Â COVID-19
Interventions: Â Drug:Â BIÂ 764198; Â Drug:Â Placebo
Sponsor:  Boehringer Ingelheim
Not yet recruiting
Comparison of Two Different Doses of Bemiparin in COVID-19 - Condition: Â COVID-19
Intervention:  Drug: Bemiparin sodium
Sponsor: Â Clinica Universidad de Navarra, Universidad de Navarra
Recruiting
An Outpatient Study Investigating Non-prescription Treatments for COVID-19 - Condition: Â COVID-19
Interventions:  Other: chlorine dioxide;  Dietary Supplement: zinc acetate;  Drug: Famotidine;  Other: placebo;  Dietary Supplement: lactoferrin, green tea extract
Sponsor:  Profact, Inc.
Not yet recruiting
A Study Evaluating the Efficacy and Safety of CKD-314 (Nafabelltan) in Hospitalized Adult Patients Diagnosed With COVID-19 Pneumonia - Condition: Â COVID-19
Intervention:  Drug: Nafamostat Mesilate
Sponsor:  Chong Kun Dang Pharmaceutical
Recruiting
Angiotensin 1-7 as a Therapy in the Treatment of COVID-19 - Condition: Â COVID-19
Intervention:  Drug: Angiotensin 1-7
Sponsors:  Rambam Health Care Campus;  Constant Therapeutics
Not yet recruiting
Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection - Condition: Â Covid19
Interventions:  Drug: Clarithromycin 500mg;  Drug: Azithromycin;  Drug: Placebo
Sponsor:  South Valley University
Completed
Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants - Condition: Â Covid19
Interventions: Â Drug:Â CNM-ZnAg; Â Drug:Â Placebo
Sponsors:  Clene Nanomedicine;  ICL Pharma;  Azidus Brazil
Not yet recruiting
Efficacy and Safety of Two Hyperimmune Equine Anti Sars-CoV-2 in COVID-19 Patients - Condition: Â Covid19
Intervention: Â Biological: Administration of Equine immunoglobulin anti SARS-CoV-2
Sponsors:  Caja Costarricense de Seguro Social;  Universidad de Costa Rica;  Ministry of Health Costa Rica
Recruiting
Mesenchymal Stem Cells in Patients Diagnosed With COVID-19 - Condition: Â Covid19
Interventions: Â Biological:Â MSC; Â Other:Â Control
Sponsors:  Hospital Reg. Lic. Adolfo Lopez Mateos;  Instituto de Terapia Celular: ITC
Recruiting
Diagnostic Performance Evaluation of a Novel SARS-CoV-2 (COVID-19) Antigen Detection Test - Conditions: Â Covid19; Â SARS-CoV-2Â Infection
Interventions:  Diagnostic Test: RT-qPCR test;  Diagnostic Test: COVID-VIROŸ test
Sponsor:  Centre Hospitalier RĂ©gional dâOrlĂ©ans
Recruiting
plasmApuane CoV-2 : Efficacy and Safety of Immune Covid-19 Plasma in Covid-19 Pneumonia in Non ITU Patients - Condition: Â Covid-19Â Pneumonia
Intervention:  Biological: immune plasma
Sponsor:  Azienda USL Toscana Nord Ovest
Recruiting
Evaluation of the Efficacy of Xylitol Nasal Spray Against SARS-CoV-2 - Condition: Â Covid19
Intervention:  Drug: Nasal Spray
Sponsors:  Larkin Community Hospital;  Ferrer Medical Innovations;  Xlear
Recruiting
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Full auction for IPL 2021 - It is understood that BCCI has plans to add a ninth team to the fold
Morikawa not intimidated by Masters challenge - PGA Championship winner says he has done his prep work
Lovlina fighting to remain focused - Stays afloat in the face of a string of adversities
Six-time champion Marquez not to return before 2021 - He has been sidelined since crashing out of the Spanish Grand Prix on July 19
Prannoy working on improving his fitness - The shuttler aims to qualify for the Olympic Games and better his ranking
Australian menâs team to wear Indigenous jersey in T20s against India - It is aimed at recognising and encouraging the Indigenous Australiansâ role in cricket
It was mentally tough in bio-bubble: Ganguly thanks players for commitment to IPL success - Following months of deliberation, it was shifted to the UAE venues of Dubai, Sharjah and Abu Dhabi and was conducted in a bio-secure environment.
IPL 2020 | I shouldâve sacrificed my wicket for Surya: Rohit - Yadav, who accumulated 480 runs this season averaging 40 with a strike rate of 145, said he didnât mind the sacrifice as he knew the skipper would lead the team through.
West Indies cricket squad sanctioned for breaching isolation rules - New Zealandâs Ministry of Health said CCTV footage from the teamâs Christchurch hotel showed players mingling in hallways and sharing food in violation of managed isolation regulations.
Chinaâs Chen Meng claims ITTF Womenâs World Cup title - Chenâs victory at the bio-secure Weihai Nanhai Olympic Center made her the first winner of the ITTFâs #RESTART series and also took her tally of senior singles titles to 19.
India gifts 20 horses, 10 mine detection dogs to Bangladesh Army - India on Tuesday gifted 20 fully trained military horses and 10 mine detection dogs to the Bangladesh Army. These were trained by the Remount and Vete
Punjab recruits 482 new medical officers amid COVID-19 pandemic - Move to meet staff shortages, provide employment
Bihar Assembly polls | NDA overcomes stiff challenge to retain power in Bihar - The ruling coalition won 125 seats in the 243-member State Assembly against 110 clinched by the Opposition Grand Alliance.
Legacy war in Nandigram as Trinamool, its Minister hold separate rallies - In a veiled attack on party, Suvendu Adhikari says they will meet âon the battlefieldâ
CBI books Best Foods, others in bank fraud - Bank consortium cheated of âč1,006.46 crore
Meghalaya govt encouraging illegal coal mining, says NGO - Accusation follows scathing attack by Opposition Congress in Assembly over the issue
Class 10 J&K board exams begin in Kashmir - The examination centres have been almost doubled from the previous year to ensure adherence to social distancing norms.
Bihar Assembly election | âWe are happy with LJPâs poll impact,â says Chirag Paswan - The Lok Janshakti Party won just one seat of Manihari in Begusarai district, but it affected the prospects of the NDA alliance partner JD(U) in nearly 20 seats.
Data | Bihar Assembly election 2020: A matter of alliance cohesion - The Mahagathbandhan fell short due to the poor performance of the Congress in the seats it contested
PM Modi to co-chair virtual India-ASEAN summit on Thursday - MEA said the summit will review the status of ASEAN-India strategic partnership.
Nagorno-Karabakh: Russia deploys peacekeeping troops to region - Hundreds of troops are deployed after Armenia and Azerbaijan agreed to end six weeks of war.
Denmark mink cull: Government admits culling had no legal basis - PM Mette Frederiksen apologises for going ahead with the mass cull of mink without new legislation.
Catholic Church abuse: Vatican defends handling of McCarrick case - Theodore McCarrick was expelled from the priesthood after an inquiry found him guilty of sex abuse.
Coronavirus: Russia resists lockdown and pins hopes on vaccine - An ice rink is being used to treat Covid patients as Russia hopes its Sputnik V vaccine will resolve the crisis.
Coronavirus: Turkish Germans raise new Covid vaccine hopes - A husband and wife from Turkish immigrant families spearhead a vaccine breakthrough.
Norwich Cathedral given Edith Cavellâs âlast World War One letterâ - Edith Cavell wrote to her mother just days before she was arrested and shot during World War One.
Why Biden tapped several Big Tech staffers for his transition team - A number of Obama staffers got tech jobs during Trumpâs term. Now theyâre back. - link
England faces a proper âargy-bargyâ in Pennyworth S2 trailer - S1 now available for streaming on Amazon Prime, so itâs the perfect time to catch up. - link
Dutch scientists reconstruct spread of coronavirus through mink farms - So far, however, no evidence of dangerous mutations being selected in mink. - link
Ubuntu fixes bugs that standard users could use to become root - A handful of commands was all it took for untrusted users to become all-powerful. - link
James Corden is a snarky AI that might take out humanity in Superintelligence - Director Ben Falcone opted to release the film on HBO Max even before the pandemic. - link
Microsoft engineer gets nine years for stealing $10M from Microsoft - The defendant triedâand failedâto use bitcoin to cover his tracks. - link
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A Jewish pilot and Chinese pilot are flying together for the 1st time. -
+My girlfriend dressed up as a policewoman and told me I was under arrest on suspicion of being good in bed. -
-An hour into the flight, the Jewish pilot says to his Chinese counterpart âI donât like the Chinese.â -
--Stunned, the Chinese pilot replies âWhy donât you like the Chinese?â -
--âWellâ says the Jew, âthe Chinese bombed Pearl Harbor.â -
--Even more stunned, he replies âThe Chinese didnât bomb Pearl Harbor! It was the Japanese!â -
--âWell, Chinese, Japanese, Vietnamese, theyâre all the same to me.â says the Jew. -
--The Chinese pilot is seething at this, and after a while he turns to his Jewish counterpart to say âI donât like the Jews.â -
--âWhat?â asks the Jew. âWhy donât you like Jews?â -
--âWellâ he says, âThe Jews sank the Titanic.â -
--The Jewish pilot scoffs at this, âThe Jews didnât sink the Titanic! An Iceberg sank the Titanic!â -
--âWellâ he replies, âIceberg, Goldberg, Rosenberg, theyâre all the same to me.â +After 2 minutes all charges were dropped due to a lack of evidence.
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Why do vampires usually pull out during sex? -
+ submitted by /u/F12BIXXH
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What is the difference between a literalist and a kleptomaniac? -
-They canât come inside without an invitation. +A comma. A literalist takes everything literally. A kleptomaniac takes everything, literally.
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What should we do with people who rely on government handouts, but refuse to work? -
+ submitted by /u/Pizzareno
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How many clickbait articles does it take to change a lightbulb? -
-Kick them out of Congress +The answer will shock youâŠ
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