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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Indonesian Economic Disruption in Covid-19 Pandemic</strong> -
<div>
Global economic has been affected Indonesia for several years. It get worse because of Covid-19 that has been affected all over the world include Indonesia. This pandemic is impact Indonesian economic growth. According to ministry of finance (CNN Indonesia,2020), Sri Mulyani said that the spread of Corona virus is still increasing every time and the financial impact will be more serious, so it impact to Indonesian Economy for sure. The cause of the slump in economic growth is because of the decrease of household consumption, investment and government consumption. Sri Mulyani said that house hold consumption decreased from 3, 2% to 1, 6%. It’s really bad effect many company in Indonesia, they have a slump income.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/ugt7f/" target="_blank">Indonesian Economic Disruption in Covid-19 Pandemic</a>
</div></li>
<li><strong>Cognitive Reappraisal and Self-Compassion as Emotion Regulation Strategies for Parents during COVID-19: An Online Randomized Controlled Trial</strong> -
<div>
Objective. Parenting during pandemic restrictions places extreme demands on everyday family life, leading to increased stress levels for parents and distressed parent-child interactions. This RCT aimed to investigate whether cognitive reappraisal and self-compassion are helpful emotion regulation (ER) strategies to reduce individual and parental stress during the COVID-19 pandemic. Method. An online intervention for parents was developed focusing on the application of ER strategies to pandemic requirements of families. A sample of 265 parents were randomly assigned to either cognitive reappraisal (CR; n = 88), self-compassion (SC; n = 90) or wait-list control (WLC; n = 87) group. Interventions included two video sessions (day 1 and day 3) and three email reminders to transfer the application of ER strategies to daily family life (days 2, 4, 5). Parents’ perceived individual stress and parental stress were assessed at baseline (T0), at T1 prior to the booster session on day 3, and at T2 (7 days after baseline). Results. Significant decreases from T0 to T2 emerged for both primary stress outcomes in both intervention groups. Individual stress significantly decreased in CR compared to WLC at T2, but not compared to SC. No time × group interactions for parental stress were found. However, mediation analyses suggested that parental stress was indirectly decreased via reductions in individual stress for CR compared to WLC at both time points. Conclusions. COVID-19 will not be the last pandemic to affect family life. Cognitive reappraisal as a brief online intervention can ease acute stress and strengthen the mental health of parents in acute crises.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/7fue9/" target="_blank">Cognitive Reappraisal and Self-Compassion as Emotion Regulation Strategies for Parents during COVID-19: An Online Randomized Controlled Trial</a>
</div></li>
<li><strong>System-wide hematopoietic and immune signaling aberrations in COVID-19 revealed by deep proteome and phosphoproteome analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has become a global crisis. To gain systems-level insights into its pathogenesis, we compared the blood proteome and phosphoproteome of ICU patients with or without SARS-CoV-2 infection, and healthy control subjects by quantitative mass spectrometry. We find that COVID-19 is marked with hyperactive T cell and B cell signaling, compromised innate immune response, and dysregulated inflammation, coagulation, metabolism, RNA splicing, transcription and translation pathways. SARS-CoV-2 infection causes global reprogramming of the kinome and kinase-substrate network, resulting in defective antiviral defense via the CK2-OPN-IL-12/IFN-I axis, lymphocyte cell death via aberrant JAK/STAT signaling, and inactivation of innate immune cells via inhibitory SIRPA, SIGLEC and SLAM family receptor signaling. Our work identifies CK2, SYK, JAK3, TYK2 and IL-12 as potential targets for immunomodulatory treatment of severe COVID-19 and provides a valuable approach and resource for deciphering the mechanism of pathogen-host interactions.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.19.21253675v1" target="_blank">System-wide hematopoietic and immune signaling aberrations in COVID-19 revealed by deep proteome and phosphoproteome analysis</a>
</div></li>
<li><strong>“It is the only constant in what feels like a completely upside down and scary world”: Living with an Eating Disorder during COVID-19 and the importance of perceived control for recovery and relapse.</strong> -
<div>
Background: The COVID-19 pandemic has had a profound, negative impact on the lives and wellbeing of the population, and it can raise additional challenges for individuals with eating disorders. During early stages of the UK lockdown, individuals reported disruptions to many aspects of their lives, including reduced feelings of control and serious concerns over the impact of the pandemic on eating disorder symptoms and/or recovery. This study compares data from two time points to explore the ongoing impacts of the pandemic on this population. Method: A mixed-methods online survey was developed for the purpose of this study. Data was collected at the two key time points: First, soon after the start of the first UK lockdown (April 2020) and second, as the first lockdown restrictions began to be lifted (June 2020). The sample consisted of 58 individuals currently experiencing, or in recovery from, an eating disorder. Participants were aged between 16-65 years; 57 identified as female, and 1 male. Results: Higher perceptions of general, external control were associated with recovery between the time points. Individuals who experienced less perceived control reported a tendency to rely upon eating disorder behaviours as an auxiliary coping mechanism, i.e., diminished external control was directed inwards and replaced with controlling their own behaviour. Conclusions: Perceived control is a significant factor in eating disorder recovery. As a result of the pandemic’s negative impact upon peoples’ sense of control, individuals with eating disorders are at significant risk of detrimental impacts on their recovery and wellbeing. The results have implications for future treatments based on strengthening individuals’ perceptions of control to promote recovery.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/tqfsz/" target="_blank">“It is the only constant in what feels like a completely upside down and scary world”: Living with an Eating Disorder during COVID-19 and the importance of perceived control for recovery and relapse.</a>
</div></li>
<li><strong>Genetic screening for TLR7 variants in young and previously healthy men with severe COVID-19: a case series</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Advanced age, male sex and chronic comorbidities are associated with severe COVID-19. However, these general risk factors cannot explain why critical illness occurs in young and apparently healthy individuals. In the past months, several publications have identified susceptibility loci and genes using comprehensive GWAS studies or genome, exome or candidate genes analysis. A recent study reported rare, loss-of-function TLR7 variants in otherwise healthy young brother pairs from two families with severe COVID-19. We aimed to prospectively study the prevalence of rare X-chromosomal TLR7 genetic variants in our cohort of young male patients with severe COVID-19. We recruited 13 patients ≤50 years who had no risk factors known to be associated with severe disease. We studied the entire TLR7 coding region and identified two missense variants (p.Asn215Ser, c.644A&gt;G and p.Trp933Arg, c.2797T&gt;C) in two out of 13 cases (15.4%). These variants were not previously reported in population control databases (gnomAD) and were predicted to be damaging by all in silico predictors. The male index patients were between 25 and 30 years old and had no apparent comorbidities. The TLR7 p.Asn215Ser co-segregated in 2 first-degree relatives severely affected by COVID-19, in a younger previously healthy the variant was found in hemizygous state , and in an older than 60 was in heterozygous state. No family members were available for testing the segregation of the p.Trp933Arg variant. These results further support that susceptibility to severe COVID-19 could be determined by inherited rare genetic variants in TLR7. Understanding the causes and mechanisms of life-threatening COVID-19 is crucial and could lead to novel preventive and therapeutic options. This study supports a rationale for the genetic screening for TLR7 variants in young men with severe COVID-19 in the absence of other relevant risk factors. A diagnosis of TLR7 deficiency could not only inform on treatment options for the patient, but it also enables for pre-symptomatic testing of at-risk male relatives with the possibility of instituting early preventive and therapeutic interventions.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.14.21252289v1" target="_blank">Genetic screening for TLR7 variants in young and previously healthy men with severe COVID-19: a case series</a>
</div></li>
<li><strong>Emergence of porcine delta-coronavirus pathogenic infections among children in Haiti through independent zoonoses and convergent evolution</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, coronavirus emergence in our species has been associated with zoonotic transmissions from animal reservoirs, underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family Coronaviridae (Alphacoronavirus, Betacoronavirus, Deltacoronavirus, Gammacoronavirus), human infections reported to date have been limited to alpha and betacoronaviruses. We identify, for the first time, porcine deltacoronavirus (PDCoV) strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the nsp15 and the spike glycoprotein genes by convergent evolution. In particular, structural analysis predicts that one of the changes in the Spike S1 subunit, which contains the receptor-binding domain, may affect flexibity of the protein and binding to the host cell receptor. Our findings not only underscore the ability of deltacoronaviruses to adapt and potentially lead to human-to-human transmission, but also raise questions about the role of such transmissions in development of pre-existing immunity to other coronaviruses, such as SARS-CoV-2.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.19.21253391v1" target="_blank">Emergence of porcine delta-coronavirus pathogenic infections among children in Haiti through independent zoonoses and convergent evolution</a>
</div></li>
<li><strong>The Stress and Anxiety to Viral Epidemics-6 items (SAVE-6): A new instrument for assessing anxiety response to viral epidemics in the general population during the COVID-19 pandemic</strong> -
<div>
During the COVID-19 pandemic, people have reported experiencing anxiety in response to the viral epidemic. This study aimed to explore the validity and usefulness of the Stress and Anxiety to the Viral Epidemic-6 items (SAVE-6) scale for measuring the anxiety response to the viral epidemic of the general population. A total of 1,009 respondents participated in an online survey, and 501 (49.7%) participants were rated as having at least a mild degree of anxiety response to the viral epidemic (SAVE-6 score ≥ 15), whereas 90 (8.9%) and 91 (9.0%) were rated as having depression and anxiety, respectively. The SAVE-6 scales showed good internal consistency (Cronbach’s α = .82). Confirmatory factor analysis supported a one-factor structure for the measure. Goodness-of-fit indices (χ2/df ratio = 19.1, CFI = .92; TLI = .86; SRMR = 0.05; RMSEA = .13) were adequate. The SAVE-6 was found to be a reliable, valid, and useful brief measure that can be applied to the general population. The SAVE-6 may be useful for easily assessing the anxiety symptoms during the pandemic in the general population.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/bv56s/" target="_blank">The Stress and Anxiety to Viral Epidemics-6 items (SAVE-6): A new instrument for assessing anxiety response to viral epidemics in the general population during the COVID-19 pandemic</a>
</div></li>
<li><strong>Rapid, widespread, and preferential increase of SARS-CoV-2 B.1.1.7 variant in Houston, TX, revealed by 8,857 genome sequences</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Genetic variants of the SARS-CoV-2 virus have become of great interest worldwide because they have the potential to detrimentally alter the course of the SARS-CoV-2 pandemic, and disease in individual patients. We recently sequenced 20,453 SARS-CoV-2 genomes from patients with COVID-19 disease in metropolitan Houston (population 7 million), dating from March 2020 to early February 2021. We discovered that all major variants of concern or interest are circulating in the region. To follow up on this discovery, we analyzed 8,857 genome sequences from patients in eight Houston Methodist hospitals dispersed throughout the metroplex diagnosed from January 1, 2021 to March 7, 2021. This sample represents 94% of Houston Methodist cases and 4.8% of all reported cases in metropolitan Houston during this period. We discovered rapid, widespread, and preferential increase of the SARS-CoV-2 UK B.1.1.7 throughout the region. The estimated case doubling time in the Houston area is 6.9 days. None of the 648 UK B.1.1.7 samples identified had the E484K change in spike protein that can cause decreased recognition by antibodies.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.16.21253753v1" target="_blank">Rapid, widespread, and preferential increase of SARS-CoV-2 B.1.1.7 variant in Houston, TX, revealed by 8,857 genome sequences</a>
</div></li>
<li><strong>The impact of COVID-19 vaccination campaigns accounting for antibody-dependent enhancement</strong> -
<div>
Background: COVID-19 vaccines are approved, vaccination campaigns are launched, and worldwide return to normality seems within close reach. Nevertheless, concerns about the safety of COVID-19 vaccines arose, due to their fast emergency approval. In fact, the problem of antibody-dependent enhancement was raised in the context of COVID-19 vaccines. Methods and findings: We introduce a complex extension of the model underlying the pandemic preparedness tool CovidSim 1.1 (http://covidsim.eu/) to optimize vaccination strategies with regard to the onset of campaigns, vaccination coverage, vaccination schedules, vaccination rates, and efficiency of vaccines. Vaccines are not assumed to immunize perfectly. Some individuals fail to immunize, some reach only partial immunity, and - importantly - some develop antibody-dependent enhancement, which increases the likelihood of developing symptomatic and severe episodes (associated with higher case fatality) upon infection. Only a fraction of the population will be vaccinated, reflecting vaccination hesitancy or contraindications. The model is intended to facilitate decision making by exploring ranges of parameters rather than to be fitted by empirical data. We parameterized the model to reflect the situation in Germany and predict increasing incidence (and prevalence) in early 2021 followed by a decline by summer. Assuming contact reductions (curfews, social distancing, etc.) to be lifted in summer, disease incidence will peak again. Fast vaccine deployment contributes to reduce disease incidence in the first quarter of 2021, and delay the epidemic outbreak after the summer season. Higher vaccination coverage results in a delayed and reduced epidemic peak. A coverage of 75% - 80% is necessary to prevent an epidemic peak without further drastic contact reductions. Conclusions: With the vaccine becoming available, compliance with contact reductions is likely to fade. To prevent further economic damage from COVID-19, high levels of immunization need to be reached before next year’s flu season, and vaccination strategies and disease management need to be flexibly adjusted. The predictive model can serve as a refined decision support tool for COVID-19 management.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.04.425198v3" target="_blank">The impact of COVID-19 vaccination campaigns accounting for antibody-dependent enhancement</a>
</div></li>
<li><strong>Arginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication</strong> -
<div>
Viral proteins are known to be methylated by host protein arginine methyltransferases (PRMTs) playing critical roles during viral infections. Herein, we show that PRMT1 methylates SARS-CoV-2 nucleocapsid (N) protein at residues R95 and R177 within RGG/RG sequences. Arginine methylation of N protein was confirmed by immunoblotting viral proteins extracted from SARS-CoV-2 virions isolated by cell culture. We demonstrate that arginine methylation of N protein is required for its RNA binding capacity, since treatment with a type I PRMT inhibitor (MS023) or substitution of R95K or R177K inhibited interaction with the 5’-UTR of the SARS-CoV-2 genomic RNA. We defined the N interactome in HEK293 cells with or without MS023 treatment and identified PRMT1 and many of its RGG/RG substrates including the known interactor, G3BP1, and other components of stress granules (SG). Methylation of N protein at R95 regulates another function namely its property to suppress the formation of SGs. MS023 treatment or R95K substitution blocked N-mediated suppression of SGs. Also, the co-expression of methylarginine reader TDRD3 quenched N-mediated suppression of SGs in a dose-dependent manner. Finally, pre-treatment of VeroE6 cells with MS023 significantly reduced SARS-CoV-2 replication. With type I PRMT inhibitors being in clinical trials for cancer treatment, inhibiting arginine methylation to target the later stages of the viral life cycle such as viral genome packaging and assembly of virions may be an additional therapeutic application of these drugs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.24.436822v1" target="_blank">Arginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication</a>
</div></li>
<li><strong>Factors Associated with Emerging and Re-emerging of SARS-CoV-2 Variants</strong> -
<div>
Global spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has triggered unprecedented scientific efforts, as well as containment and treatment measures. Despite these efforts, SARS-CoV-2 infections remain unmanageable in some parts of the world. Due to inherent mutability of RNA viruses, it is not surprising that the SARS-CoV-2 genome has been continuously evolving since its emergence. Recently, four functionally distinct variants, B.1.1.7, B.1.351, P.1 and CAL.20C, have been identified, and they appear to more infectious and transmissible than the original (Wuhan-Hu-1) virus. Here we provide evidence based upon a combination of bioinformatics and structural approaches that can explain the higher infectivity of the new variants. Our results show that the greater infectivity of SARS-CoV-2 than SARS-CoV can be attributed to a combination of several factors, including alternate receptors. Additionally, we show that new SARS-CoV-2 variants emerged in the background of D614G in Spike protein and P323L in RNA polymerase. The correlation analyses showed that all mutations in specific variants did not evolve simultaneously. Instead, some mutations evolved most likely to compensate for the viral fitness.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.24.436850v1" target="_blank">Factors Associated with Emerging and Re-emerging of SARS-CoV-2 Variants</a>
</div></li>
<li><strong>New detection of SARS-CoV-2 in two cats height months after COVID-19 outbreak appearance in France</strong> -
<div>
Although there are several reports in the literature of SARS-CoV-2 infection in cats, few SARS-CoV-2 sequences from infected cats have been published. In this report, SARS-CoV-2 infection was evaluated in two cats by clinical observation, molecular biology (qPCR and NGS), and serology (Microsphere immunoassay and seroneutralization). Following the observation of symptomatic SARS-CoV-2-infection in two cats, infection status was confirmed by RT-qPCR and, in one cat, serological analysis for antibodies against N-protein and S-protein, as well as neutralizing antibodies. Comparative analysis of five SARS-CoV-2 sequence-fragments obtained from one of the cats showed that this infection was not with one of the three recently emerged variants of SARS-CoV-2. This study provides additional information on the clinical, molecular, and serological aspects of SARS-CoV-2 infection in cats.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.24.436830v1" target="_blank">New detection of SARS-CoV-2 in two cats height months after COVID-19 outbreak appearance in France</a>
</div></li>
<li><strong>Oxygen provision to severely ill COVID-19 patients at the peak of the 2020 pandemic in a Swedish district hospital</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Oxygen is a low-cost and life-saving therapy for patients with COVID-19. Yet, it is a limited resource in many hospitals in low income countries and in the 2020 pandemic even hospitals in richer countries reported oxygen shortages. An accurate understanding of oxygen requirements is needed for capacity planning. The World Health Organization estimates the average flow-rate of oxygen to severe COVID-19-patients to be 10 l/min. However, there is a lack of empirical data about the oxygen provision to patients. This study aimed to estimate the oxygen provision to COVID-19 patients with severe disease in a Swedish district hospital. A retrospective, medical records-based cohort study was conducted in March to May 2020 in a Swedish district hospital. All adult patients with severe COVID-19, those who received oxygen in the ward and had no ICU-admission during their hospital stay, were included. Data were collected on the oxygen flow-rates provided to the patients throughout their hospital stay, and summary measures of oxygen provision calculated. One-hundred and twenty six patients were included, median age was 70 years and 43% were female. On admission, 27% had a peripheral oxygen saturation of &lt;=91% and 54% had a respiratory rate of &gt;=25/min. The mean oxygen flow-rate to patients while receiving oxygen therapy was 3.0 l/min (SD 2.9) and the mean total volume of oxygen provided per patient admission was 16,000 l (SD 23,000). In conclusion, the provision of oxygen to severely ill COVID-19-patients was lower than previously estimated. Further research is required before global estimates are adjusted.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.11.21253350v2" target="_blank">Oxygen provision to severely ill COVID-19 patients at the peak of the 2020 pandemic in a Swedish district hospital</a>
</div></li>
<li><strong>Characterizing the COVID-19 illness experience to inform the study of post-acute sequelae and recovery: a qualitative study</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
We aimed to characterize the variability in the illness experience and recovery process from COVID-19. We conducted 24 in-depth individual interviews with participants enrolled in the Long-term Immunological Impact of Novel Coronavirus (LIINC) cohort study in San Francisco, California from June through October of 2020. Participants were adults who had a previously confirmed positive SARV-CoV-2 nucleic acid amplification test result, had recovered or were recovering from acute infection, and underwent serial evaluations at our clinical research center. We purposefully sampled 24 English- and Spanish-speaking adults with asymptomatic, mild and severe symptomatic infection, including those who were hospitalized, and those with HIV co-infection. Half of our sample (50.0%) identified as Latinx/Hispanic and most of the participants were men (62.5%). We used thematic analysis to characterize the illness experience, recovery process, and mental health impact of experiencing COVID-19 and present clinical data for each participant. Emergent themes were: (1) across symptom profiles and severity, experiencing COVID-19 was associated with psychological distress, (2) among participants with symptomatic infection, the illness experience was characterized by uncertainty in terms of managing symptoms and recovery, and (3) despite wide-ranging illness experiences, participants shared many common characteristics, including health information-seeking behavior facilitated by access to medical care, and uncertainty regarding the course of their illness and recovery. COVID-19 was associated with elevated levels of psychological distress, regardless of symptoms.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.10.21253330v2" target="_blank">Characterizing the COVID-19 illness experience to inform the study of post-acute sequelae and recovery: a qualitative study</a>
</div></li>
<li><strong>Untangling the cell immune response dynamic for severe and critical cases of SARS-CoV-2 infection</strong> -
<div>
COVID-19 is a global pandemic leading high death tolls worldwide day by day. Clinical evidence suggests that COVID-19 patients can be classified as non-severe, severe and critical cases. In particular, studies have highlighted the relationship between the lymphopenia and the severity of the illness, where CD8+ T cells have the lowest levels in critical cases. In this work, we aim to elucidate the key parameters that define the course of the disease deviating from severe to critical case. To this end, several mathematical models are proposed to represent the dynamic of the immune response in patients with SARS-CoV-2 infection. The best model had a good fit to reported experimental data, and in accordance with values found in the literature. Our results suggest that a rapid proliferation of CD8+ T cells is decisive in the severity of the disease.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.23.436686v1" target="_blank">Untangling the cell immune response dynamic for severe and critical cases of SARS-CoV-2 infection</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pilot Trial of XFBD, a TCM, in Persons With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Xuanfei Baidu Granules;   Other: Placebo<br/><b>Sponsor</b>:   Darcy Spicer<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Tolerability of Emricasan in Symptomatic Outpatients Diagnosed With Mild-COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Emricasan;   Other: Placebo<br/><b>Sponsor</b>:   Histogen<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Reinforcing Standard Therapy in COVID-19 Patients With Repeated Transfusion of Convalescent Plasma</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Convalescent Plasma with antibody against SARS-CoV-2.;   Other: Standard treatment for COVID-19<br/><b>Sponsors</b>:   Hospital Son Llatzer;   Fundació d’investigació Sanitària de les Illes Balears<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SERUR: COVID-19 Serological Survey of Staff From the University Reims-Champagne Ardennes</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: Anti-SARS-CoV2 Serology<br/><b>Sponsor</b>:   Université de Reims Champagne-Ardenne<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ANTIcoagulation in Severe COVID-19 Patients</strong> - <b>Condition</b>:   Severe COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: Tinzaparin, Low dose prophylactic anticoagulation;   Drug: Tinzaparin, High dose prophylactic anticoagulation;   Drug: Tinzaparin,Therapeutic anticoagulation<br/><b>Sponsor</b>:   Assistance Publique - Hôpitaux de Paris<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neuromodulation in COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Device: Transcranial direct-current stimulation;   Device: Sham Transcranial direct-current stimulation<br/><b>Sponsors</b>:   D’Or Institute for Research and Education;   Rio de Janeiro State Research Supporting Foundation (FAPERJ);   Conselho Nacional de Desenvolvimento Científico e Tecnológico;   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety of Recombinant COVID-19 Vaccine (CHO Cells)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: a middle-dose recombinant COVID-19 vaccine (CHO Cell) (18-59 years) at the schedule of day 0, 28, 56;   Biological: a high-dose recombinant COVID-19 vaccine (CHO Cell) (18-59 years) at the schedule of day 0, 28, 56;   Biological: a middle-dose recombinant COVID-19 vaccine (CHO Cell) (60-85 years) at the schedule of day 0, 28, 56;   Biological: a high-dose recombinant COVID-19 vaccine (CHO Cell) (60-85 years) at the schedule of day 0, 28, 56;   Biological: a middle-dose placebo (18-59 years) at the schedule of day 0, 28, 56;   Biological: a high-dose placebo (18-59 years) at the schedule of day 0, 28, 56;   Biological: a middle-dose placebo (60-85 years) at the schedule of day 0, 28, 56;   Biological: a high-dose placebo (60-85 years) at the schedule of day 0, 28, 56<br/><b>Sponsors</b>:   Jiangsu Province Centers for Disease Control and Prevention;   Academy of Military Medical Sciences，Academy of Military Sciences，PLA ZHONGYIANKE Biotech Co, Ltd. LIAONINGMAOKANGYUAN Biotech Co, Ltd<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Off-the-shelf NK Cells (KDS-1000) as Immunotherapy for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: KDS-1000;   Other: Placebo<br/><b>Sponsor</b>:   Kiadis Pharma<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Assess if a Medicine Called Bamlanivimab is Safe and Effective in Reducing Hospitalization Due to COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Bamlanivimab;   Other: Standard of Care<br/><b>Sponsors</b>:   Fraser Health;   Fraser Health Authrority Department of Evaluation and Research Services;   Surrey Memorial Hospital Clinical Research Unit;   Centre for Health Evaluation and Outcome Sciences;   Surrey Hospitals Foundation;   BC Support Unit;   University of British Columbia;   Ministry of Health, British Columbia<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Telerehabilitation After Discharge in COVID-19 Survivors</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Telerehabilitation<br/><b>Sponsor</b>:   Hacettepe University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Corticosteroids for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Prednisone;   Device: Point of Care testing device for C-reactive protein<br/><b>Sponsor</b>:   University of Alberta<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Post COVID-19 Syndrome and the Gut-lung Axis</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: Omni-Biotic Pro Vi 5;   Dietary Supplement: Placebo<br/><b>Sponsors</b>:   Medical University of Graz;   CBmed Ges.m.b.H.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid-19 Vaccination in Adolescents</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Tozinameran;   Biological: Oxford-AstraZeneca COVID-19 vaccine;   Biological: CoronaVac<br/><b>Sponsor</b>:   The University of Hong Kong<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Adaptogens in Patients With Long COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: ADAPT-232 oral solution;   Other: Placebo oral solution<br/><b>Sponsors</b>:   Swedish Herbal Institute AB;   National Family Medicine Training Centre, Georgia;   Tbilisi State Medical University;   Phytomed AB<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Improved Oxygen Therapy in Covid-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: oxygen mask<br/><b>Sponsor</b>:   Region Skane<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of HECT E3 ligases as potential therapy for COVID-19</strong> - SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken more than two million lives. Effective treatments are urgently needed. The enzymatic activity of the HECT-E3 ligase family members has been implicated in the cell egression phase of deadly RNA viruses such as Ebola through direct interaction of its VP40 Protein. Here we report that HECT-E3 ligase family members such as NEDD4 and WWP1 interact with and ubiquitylate the SARS-CoV-2 Spike protein. Furthermore, we…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effectiveness and safety review of Chinese herbal sachets for external use in the treatment of COVID-19 pandemic: A protocol for systematic review and meta-analysis</strong> - CONCLUSION: This systematic review will provide evidence whether Chinese herbal sachets are effective and safe intervention of COVID-19 Pandemic.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection</strong> - Antiviral agents with different mechanisms of action could induce synergistic effects against SARS-CoV-2 infection. Some reports suggest the therapeutic potential of the heme oxygenase-1 (HO-1) enzyme against virus infection. Given that hemin is a natural inducer of the HO-1 gene, the aim of this study was to develop an in vitro assay to analyze the antiviral potency of hemin against SARS-CoV-2 infection. A SARS-CoV-2 infectivity assay was conducted in Vero-E6 and Calu-3 epithelial cell lines….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2</strong> - The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient plasma. Little is known about neutralizing Abs binding to epitopes outside the RBD and their contribution to protection. Here, we describe 41 human monoclonal Abs (mAbs) derived from memory B cells, which recognize the SARS-CoV-2 S N-terminal domain (NTD) and show that a subset of them neutralize SARS-CoV-2 ultrapotently. We define an…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on the mechanism of active components of Liupao tea on 3CL<sup>pro</sup> based on HPLC-DAD fingerprint and molecular docking technique</strong> - Liupao tea, a drink homologous to medicine and food. It can treat dysentery, relieve heat, remove dampness, and regulate the intestines and stomach. The objective of this study is to explore the material basis and mechanism of Liupao tea intervention in COVID-19 and to provide a new prevention and treatment programme for COVID-19. We used high performance liquid chromatography to analyze the extract of Liupao tea and establish its fingerprint. The main index components of the fingerprint were…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Interleukin-6 Antagonists: Lessons From Cytokine Release Syndrome to the Therapeutic Application in Severe COVID-19 Infection</strong> - Current retrospective data have found up to 20% of COVID-19 infection had developed into severe cases with hyperinflammatory pulmonary symptoms. Interleukin 6 (IL-6) is recognized as a key mediator of hyperinflammation previously mentioned in cytokine release syndrome. This leads to implementing IL-6 pathway inhibition in severe COVID-19. This review aimed to explore the clinical evidences of using IL-6 antagonists in COVID-19 infection based on most recent available data. Relevant studies were…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Monoclonal antibodies capable of binding SARS-CoV-2 spike protein receptor-binding motif specifically prevent GM-CSF induction</strong> - A severe acute respiratory syndrome (SARS)-like coronavirus 2 (SARS-CoV-2) has recently caused a pandemic COVID-19 disease that infected approximately 94 million and killed more than 2,000,000 people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of its envelope spike protein for binding the host angiotensin-converting enzyme 2 (ACE2) to gain viral entry. Currently, extensive efforts are being made to produce vaccines against a surface fragment of a…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay</strong> - The papain-like protease (PL ^(pro) ) of SARS-CoV-2 is a validated antiviral drug target. PL ^(pro) is involved in the cleavage of viral polyproteins and antagonizing host innate immune response through its deubiquitinating and deISG15ylating activities, rendering it a high profile antiviral drug target. Through a FRET-based high-throughput screening, several hits were identified as PL ^(pro) inhibitors with IC (50) values at the single-digit micromolar range. Subsequent lead optimization led to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Circadian regulation of SARS-CoV-2 infection in lung epithelial cells</strong> - The COVID-19 pandemic, caused by SARS-CoV-2 coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the respiratory tract, via binding human angiotensin-converting enzyme (ACE2) ^(1,2) , and infection can result in pneumonia and acute respiratory dist ress syndrome. Circadian rhythms coordinate an organisms response to its environment and recent studies report a role for the circadian clock to regulate host susceptibility to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response</strong> - The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after cellular infection, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD induces interferon expression and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A molecular docking study of SARS-CoV-2 main protease against phytochemicals of Boerhavia diffusa Linn. for novel COVID-19 drug discovery</strong> - SARS-CoV-2, the causative virus of the Corona virus disease that was first recorded in 2019 (COVID-19), has already affected over 110 million people across the world with no clear targeted drug therapy that can be efficiently administered to the wide spread victims. This study tries to discover a novel potential inhibitor to the main protease of the virus, by computer aided drug discovery where various major active phytochemicals of the plant Boerhavia diffusa Linn. namely 2-3-4 beta-Ecdysone,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure Insights of SARS-CoV-2 open state envelope protein and inhibiting through active phytochemical of ayurvedic medicinal plants from Withania somnifera</strong> - Coronaviruses have been causing pandemic situations across the globe for the past two decades and the focus is on identifying suitable novel targets for antivirals and vaccine development. SARS-CoV-2 encodes a small hydrophobic envelope (E) protein that mediates envelope formation, budding, replication, and release of progeny viruses from the host. Through this study, the SARS-CoV-2 E protein is studied for its open and closed state and focused in identifying antiviral herbs used in traditional…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronil, a Tri-Herbal Formulation, Attenuates Spike-Protein-Mediated SARS-CoV-2 Viral Entry into Human Alveolar Epithelial Cells and Pro-Inflammatory Cytokines Production by Inhibiting Spike Protein-ACE-2 Interaction</strong> - CONCLUSION: Coronil prevented SARS-CoV-2 S-protein mediated viral entry into A549 cells by inhibiting spike protein-ACE-2 interactions. SARS-CoV-2 S protein induced inflammatory cytokine response in these cells was also moderated by Coronil.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex</strong> - Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of all the above-mentioned pathways. Recently, an autotransporter protein, virulence-associated gene 8 (Vag8), produced by the whooping cough pathogen, Bordetella pertussis, was shown to bind to C1-INH and interfere with its function. Here, we present the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Preparedness for self-isolation or quarantine and lockdown in South Africa: results from a rapid online survey</strong> - CONCLUSION: The findings highlight the challenge of implementing self-isolation or quarantine in a country with different and unique social contexts. There is a need for public awareness regarding the importance of self-isolation or quarantine as well as counter measures against contextual factors inhibiting this intervention, especially in impoverished communities.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Peptides and their use in diagnosis of SARS-CoV-2 infection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU319943278">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A PROCESS FOR SUCCESSFUL MANAGEMENT OF COVID 19 POSITIVE PATIENTS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU319942709">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sars-CoV-2 vaccine antigens</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318283136">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-COV-2 BINDING PROTEINS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318004130">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bildschirmgerät mit verbesserter Wirkung bei der Befestigung von UV-Entkeimungslampen</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Ein Bildschirmgerät mit verbesserter Wirkung bei der Befestigung von UV-Entkeimungslampen, umfassend: ein Bildschirmgerät, das einen Umfang hat; eine UV-Entkeimungslampe, die sich am Umfang des Bildschirmgeräts befindet; eine Stromquelle, die elektrisch mit der UV-Entkeimungslampe verbunden ist; eine Steuerschaltung, die elektrisch mit der UV-Entkeimungslampe verbunden ist; und eine Befestigungsvorrichtung, durch die die UV-Entkeimungslampe am Umfang des Bildschirmgeräts befestigbar ist, wobei die Befestigungsvorrichtung einen Sitzkörper, eine erste Klemmplatte und eine zweite Klemmplatte aufweist, wobei der Sitzkörper mit der UV-Entkeimungslampe versehen ist, wobei die erste Klemmplatte und die zweite Klemmplatte beabstandet am Sitzkörper gleitbar angeordnet sind, wodurch ein Klemmabstand zwischen der ersten Klemmplatte und der zweiten Klemmplatte besteht, wobei ein elastisches Element zwischen der zweiten Klemmplatte und dem Sitzkörper angeordnet ist, um die zweite Klemmplatte dazu zu zwingen, sich der ersten Klemmplatte zu nähern.</p></li>
</ul>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE320246402">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Schublade mit antiepidemischer Wirkung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Schublade mit antiepidemischer Wirkung, mit einem Schrank (1); mindestens einer Schublade (2), die in dem Schrank (1) angeordnet ist, wobei jede Schublade (2) einen Schubladenraum (25) aufweist; einer UV-Sterilisationsvorrichtung (3), die an der Schublade (2) angeordnet ist; einer Stromquelle (4), die elektrisch mit der UV-Sterilisationsvorrichtung (3) verbunden ist; einer Steuerschaltung (5), die elektrisch mit der Stromquelle (4) und der UV-Sterilisationsvorrichtung (3) verbunden ist; und einem Sensor (6), der elektrisch mit der Steuerschaltung (5) verbunden ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE320246401">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gerät zur Unterstützung und Verstärkung natürlicher Lüftung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Lüftungssystem für einen mit öffnbaren Fenstern (16) ausgestatteten Gebäuderaum, gekennzeichnet dadurch, dass es ein Gehäuse (18) und einen Ventilator (20) aufweist, wobei durch das Gehäuse eine vom Ventilator erzeugte Luftströmung strömen kann, wobei das Gehäuse dafür eine Einströmöffnung (24) für Luft und eine Ausströmöffnung (22) für Luft enthält, wobei eine der beiden Öffnungen der Form eines Öffnungsspalts (26) zwischen einem Fensterflügel (12) und einem Blendrahmen (14) des Fensters (16) angepasst ist.</p></li>
</ul>
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<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE319927546">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>X射线图像识别方法、装置、计算机设备及存储介质</strong> - 本申请涉及一种X射线图像识别方法、装置、计算机设备和存储介质。通过获取X射线图像，将X射线图像作为训练样本；构建多注意力交互网络，多注意力交互网络包括卷积批处理标准化网络、特征提取网络和输出网络；其中特征提取网络包括多注意力交互特征提取模块和批标准化模块，特征提取网络通过学习通道之间的相关性，多通道之间的信息交互来达到增强模型的识别能力。利用训练样本对多注意力交互网络进行训练，得到X射线图像识别模型；获取待测X射线图像；将待测X射线图像输入到X射线图像识别模型中，得到X射线图像的类别。本方法减少了网络的参数量和计算量，提高了模型的泛化能力。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN319953046">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法</strong> - 本发明提供一种利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法，包括：1）构建新冠病毒核衣壳蛋白（N蛋白）重组表达载体；2）用重组表达载体转染HEK293细胞；3）体外培养细胞，从培养上清中分离纯化N蛋白。利用HEK293表达系统可在短时间内获得大量新冠病毒N蛋白，通过一步亲和层析法可获得纯度高达98%以上的N蛋白。与大肠杆菌相比，采用HEK293表达系统制备的N蛋白在与抗体的结合活性及新冠抗体胶体金检测方面均表现出极大优势，且HEK293表达系统制备的N蛋白其蛋白空间构象接近于病毒N基因在宿主体内的蛋白表达构象，具有更高的免疫诊断和抗体制备的准确性，将其用于制作诊断试剂和疫苗前景广阔。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN319953048">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for detecting SARS-CoV-2 spike protein</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU317343760">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Should Gig Work Be Government-Run?</strong> - The labor reformer Wingham Rowan wants to reimagine labor markets for the digital age. - <a href="https://www.newyorker.com/tech/annals-of-technology/should-gig-work-be-government-run">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Humanitarian Challenge of Unaccompanied Children at the Border</strong> - A lawyer who met with children held in Border Patrol custody describes the urgency of expediting their release. - <a href="https://www.newyorker.com/news/q-and-a/the-humanitarian-challenge-of-unaccompanied-children-at-the-border">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>On the Overnight Shift with the Amazon Union Organizers</strong> - At around 4 A.M., two veteran union reps whipped votes outside the Amazon facility in Bessemer, Alabama, and swapped stories of past organizing efforts at Piggly Wigglys and a condom factory in Eufaula. - <a href="https://www.newyorker.com/magazine/2021/03/29/on-the-overnight-shift-with-the-amazon-union-organizers">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Amazon Union Drive and the Changing Politics of Labor</strong> - For the moment, Marco Rubio and Stacey Abrams are on the same side. - <a href="https://www.newyorker.com/news/annals-of-populism/the-amazon-union-drive-and-the-changing-politics-of-labor">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Do We Actually Need More Gas Stations?</strong> - Resistance rises to Costco’s plans for mega stations. - <a href="https://www.newyorker.com/news/annals-of-a-warming-planet/do-we-actually-need-more-gas-stations">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Can food carts survive the pandemic?</strong> -
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<img alt="A bacon, egg, and cheese bagel on a wooden table." src="https://cdn.vox-cdn.com/thumbor/JtDaDS992jo0y2GZDcVMmE3nTZg=/0x0:7216x5412/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69023416/GettyImages_531930358.0.jpg"/>
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Street vendors have lost their regular customers. Can they stay afloat despite the pandemic? | Getty Images
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The streets are empty, but Joanna Despas is still cooking. Here’s what it’s like to run a food cart during a pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VKwZvj">
When I walk up to Mama Jo’s Breakfast Cart, which is located two blocks away from the MetLife Building in Midtown, Manhattan, she’s already packing up the kitchen. It’s 10:15 am on a Tuesday. She typically doesn’t close until 11 am. These used to be her prime hours, but the pandemic has altered things dramatically for the food cart business. The banks are closed, the tourists are gone, and everyone is working from home. The Mama Jo of the cart’s namesake, real name Joanna Despas, tells me that she’s been lucky to get more than 20 customers per day.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NefSde">
Despas is 70 years old, originally from rural northern Greece, and started up her breakfast cart 48 years ago. She cooks a blend of New York classics (bacon, egg, and cheese) and Mediterranean staples (spanakopita, olive bread) for the passing stream of professionals on their way to the office. Before Covid-19, Despas says, she routinely had lines around the block. These days, she mostly wheels her cart into town to feed the homeless for free, and to fire up the griddle for the handful of construction workers erecting a skyscraper across the street. Despas says she’s made a negligible amount of money all year, and only shows up because it feels better to cook than to sit around at home all day.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ldxzeA">
Despas holds out hope that eventually, when Broadway is open and the streets are full of tourists again, the street vending industry will bounce back. But she’s pessimistic about the prospects of a total New York City recovery. Can Mama Jo, or any street vendor for that matter, count on an endless flow of hungry yuppies after they’ve spent a year clocking in remotely? Is there going to be a sizable chunk of her clientele who simply won’t go into the office as much? Is the Zoom revolution going to last past the vaccine? Nobody knows for sure.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c2mAhH">
We talked about how much she misses her regulars, and why, even after the seismic repercussions of the pandemic, she’s still not planning on retiring anytime soon.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L4IcvC">
<strong>Who are your usual clients right now?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iO5lJz">
Right now, nobody. Everyone works from home. We have construction workers around here, because they are essential workers. But we don’t have business, and I don’t think we’ll have business until the vaccines take hold. And even then, I don’t know how much business will come back. A lot of businesses are closed, and when you look around the city, it’s dead. Vendors are gone. They pop up here and there, but they can’t make any money out here. At this point, I’m coming only for the homeless. There are so many of them, and where else are they going to get food?
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<a href="https://www.instagram.com/p/CDmGFwdAmds/?utm_source=ig_embed&amp;utm_campaign=loading" style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" target="_blank">A post shared by Mama Jos Breakfast Cart (<span class="citation" data-cites="mama_jos_breakfast_cart">@mama_jos_breakfast_cart</span>)</a>
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</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RxTmCO">
<strong>So you’re only out here to feed the homeless?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ev6wX5">
Yes, and I have a bunch of people who help me with that. The construction workers buy food for them. They’re very nice. I have people who give me clothing and shoes that I hand out to them. I’ve noticed a lot more homeless people out here lately. They were always there, but it’s never been like this. They’re all over, and there’s no food. All the vendors have been helping out. Some of them come up to me and say, “There’s a couple people down on Eighth Avenue that need this or that,” and I get it for them. You feel a little better. You’re doing something instead of staying home. It’s good to be occupied.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hyMYQK">
<strong>Why do you think your business won’t bounce back? </strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NVccKZ">
I talk to people who work in banks and they like what they’re doing. I think they’re going to come in for a couple days a week and work from home at other times. The residential people here have moved. I think that’s how the city is going to work. It’s not going to be easy for us. If you don’t have a crowd for a year, you’re not going to build it all back the next day. It’s like starting back over from the beginning. That’s not restricted to vendors, the same goes for restaurants and delis.
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<strong>How are you holding up financially?</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EJvLVS">
No money. We’re not making any money. I’m doing okay. I’m 70 years old and I get my Social Security. My grandmother taught me to always put away money for a rainy day. So I’m okay, and my kids are okay and working from home. The big institutions are making money. The banks, the supermarkets, the franchises, they’re all doing okay. The people who are getting hurt are restaurants and vendors. It’s different out in Brooklyn and Queens, you can see some more life out there. But certainly not out here.
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<strong>How many customers are you seeing a day?</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6J5DQk">
No more than 20.
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<strong>And you used to have lines around the block, right?</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yC6Qpj">
Oh yeah, and I don’t know if that’s ever going to happen again. But I’m an optimistic person. Maybe if they open up the Broadway shows, we’ll see what happens. But a lot of people have given up in this business. The garage used to have 200 pushcarts. Now we’ve got like, 100? Maybe less? And it gets less and less, because it gets more difficult.
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<a href="https://www.instagram.com/p/CLyv5jRDH-U/?utm_source=ig_embed&amp;utm_campaign=loading" style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" target="_blank">A post shared by Mama Jos Breakfast Cart (<span class="citation" data-cites="mama_jos_breakfast_cart">@mama_jos_breakfast_cart</span>)</a>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KbsGTn">
<strong>Do you miss your regulars?</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="623tki">
Of course. I’ve got a lot of text messages from them. They leave messages on my social media. I’ve got people from all over the world that know me, and they all ask how I’m doing. They say, “I miss your food, I miss you.” They want to go back to normal. I see a lot of fear in people, and I don’t want people to fear. Fear, worry, and stress kills you, completely.
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<strong>Have you thought about moving the cart elsewhere?</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JlIpzn">
At my age, I’m not going to do that. I’m feeding the homeless, and if I’m not here I don’t know where they’re going to eat. I’m doing it for myself more than anything.
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<strong>Has anything about this year made you want to retire?</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RDUJEQ">
I’m not going to retire. I’m not that kind of person. I’m never going to stay home, because I love what I do. I was only introduced to the idea of retirement in the United States. It’s not as much of a thing in Greece. You see 80-year-olds working the fields out there. I put in 18 hours a day, and sleep like four hours at night. I’m healthy. I cook everything myself. My diet is like the ancient Greeks’ — I’ve been on this corner for 48 years, and I haven’t taken one sick day.
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<ul>
<li><strong>Facebook wants Washington’s help running Facebook</strong> -
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<img alt="A screenshot of Mark Zuckerberg talking into a microphone via videochat." src="https://cdn.vox-cdn.com/thumbor/_jZIOj8p6PfbgS65HjveHgD4h8c=/286x0:4289x3002/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69021407/1229654018.0.jpg"/>
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Mark Zuckerberg testifies remotely at a Congressional hearing in November 2020; he is scheduled to appear at another remote hearing on March 25, 2021. | Hannah McKay/Getty Images
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
But not too much help: Mark Zuckerberg has a proposal.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NKhVcV">
Facebook CEO Mark Zuckerberg has a message for Washington: We’re happy to change the way we run Facebook. Just tell us how.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ORm4o8">
That’s the main takeaway from a <a href="https://docs.house.gov/meetings/IF/IF16/20210325/111407/HHRG-117-IF16-Wstate-ZuckerbergM-20210325-U1.pdf">statement he will provide to Congress on Thursday</a>, in a hearing about social media’s role in spreading misinformation. But it’s also the mantra Zuckerberg and Facebook have been repeating for years, in targeted messaging like <a href="https://www.vox.com/2019/3/31/18289375/mark-zuckerberg-facebook-regulation-washington-post-op-ed">Washington Post op-eds</a> and paid ads aimed at the Beltway crowd.
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And it’s also, more or less, the Facebook default position when it comes to making all kinds of decisions about running the enormous and enormously profitable company: “Yes, we run a company that generated $84 billion in revenue last year and is currently worth more than $800 billion. But we’d like someone else to take responsibility for …” and here you can fill in the blank, because it can range from anything from whether a <a href="https://www.vox.com/2016/9/9/12861634/facebook-photograph-vietnam-censorship">Pulitzer Prize-winning photo can run on the site</a> to whether <a href="https://www.vox.com/recode/22242627/trump-facebook-oversight-board">Donald Trump can post on Facebook</a>.
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Now Facebook is in a position where everyone in Washington wants to do … something about Facebook, though exactly what depends on what part of the political spectrum they sit on. Republicans want Facebook to promise to stop censoring Republicans, though there isn’t any evidence that’s actually happening; Democrats want Facebook to promise not to destabilize democracy.
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So now Zuckerberg is adding a twist to his standard request for regulation: He is telling Congress it should force Facebook — and everyone else who runs an internet platform — “to demonstrate that they have systems in place for identifying unlawful content and removing it.”
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Facebook wouldn’t have to necessarily find all of that stuff and take down every last piece of it — Facebook is really big! But it would have to prove that it has spent a lot of time and money to <em>try</em> to do that.
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In return, Zuckerberg says, Facebook and everyone else who complies would get to keep the protections offered by <a href="https://www.vox.com/recode/2020/5/28/21273241/section-230-explained-trump-social-media-twitter-facebook">Section 230, a foundational piece of legislation</a> that lets online platforms host content uploaded by users without taking responsibility for that content.
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On the one hand, this seems like a fairly straightforward proposition. After all, Facebook and other big platforms like YouTube and Twitter already have systems that allow them to police copyright violations on their property. Why shouldn’t they have systems that do the same for “unlawful content”?
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(Here it’s worth noting that in the early days of the platforms, their primary legal concern was avoiding the copyright claims that brought down Napster; the notion that the platforms might host content that could incite genocide or destabilize democracy wouldn’t get much traction until a decade later.)
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KXMWO9">
On the other hand, this isn’t straightforward at all. It’s more or less clear when something violates copyright. But it won’t be at all clear what kind of content is “unlawful” — and waiting on Congress, which can’t find any kind of bipartisan agreement on anything at all, to decide exactly what Facebook should allow on its properties means Facebook will be waiting a very long time to hear what those guidelines are.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g4bjNP">
Which, you might argue, is fine with Facebook, if you believe that Facebook merely wants to appear as though it wants to work with Congress and hope all of the momentum to regulate tech goes away someday.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cfu3mj">
A different but equally realpolitik take: Facebook figures there’s going to be some kind of Section 230 reform, and by laying out a path it finds acceptable, it will have better odds of getting that result when it comes to negotiating with lawmakers and their staff. (Of note: Neither Alphabet CEO Sundar Pichai nor Twitter CEO Jack Dorsey, who are also virtually testifying at Thursday’s hearing, asked Congress to modify Section 230 at all.)
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UNsrLz">
Critics will also point out that creating these kinds of rules and systems isn’t nearly as big a problem for Facebook as it will be for smaller internet platform companies. (Remember that <a href="https://www.vox.com/recode/2019/7/24/20708359/facebook-ftc-settlement-criticism-5-billion-privacy-review-antitrust-mark-zuckerberg">Washington levied a $5 billion fine</a> and a new set of privacy guidelines on Facebook two years ago, and Facebook moved on without missing a beat because $5 billion isn’t a lot of money to Facebook.) But since this isn’t a new criticism, the company has a ready retort: Someone — not Facebook, certainly — should figure out the “definitions of an adequate system,” which “could be proportionate to platform size.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D5Fg0M">
Let’s be clear: Facebook doesn’t really want the government telling it what to do. It was happy(ish) to cut deals to <a href="https://www.vox.com/recode/2019/10/24/20929919/facebook-zuckerberg-murdoch-news-publishers-pay-content">pay Rupert Murdoch’s News Corp</a> for use of its content in America. In Australia, <a href="https://www.vox.com/recode/2021/2/20/22291425/facebook-australia-murdoch-law">Facebook threw a fit</a> when it was compelled to do the same thing by regulators there.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4pDcmP">
But what Facebook does want are legal guardrails and a promise that if it adheres to them, it can go about its very profitable business. Asking Congress to set those up — even if, or especially if, it takes a very long time — is a very small price to pay.
</p></li>
<li><strong>Dr. Rachel Levine’s historic confirmation to the Biden administration, explained</strong> -
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/nqXOpCkmgrunXN0QRa9X572jDXE=/122x0:2878x2067/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68705014/537503904.0.jpg"/>
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Rachel Levine, then physician general for the state of Pennsylvania, dines with her mother Lillian Levine in 2016, in Harrisburg, Pennsylvania. | Bonnie Jo Mount/The Washington Post/Getty Images
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In a pivotal moment for trans health care, Levine has been confirmed as assistant secretary of health.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B5Pkjq">
On Wednesday, the Senate voted to confirm former Pennsylvania Secretary of Health Dr. Rachel Levine as the new assistant secretary of health at the Department of Health and Human Services (HHS). Levine’s confirmation is historic: She is now the highest-ranking openly transgender government official in US history.
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In her new role, Levine will run the <a href="https://www.hhs.gov/ash/about-ash/organizational-chart/index.html">Office of the Assistant Secretary of Health (OASH)</a>, which oversees the nation’s public health policy. She will be a key administration figure as the White House tackles the deepening Covid-19 <a href="https://www.vox.com/coronavirus-covid19/">pandemic</a> that has claimed the lives of <a href="https://coronavirus.jhu.edu/map.html">more than 500,000 Americans</a>. But she will also play an important role in rolling back a host of Trump-era policies on reproductive, adolescent, and LGBTQ health. As a trained pediatrician with a history of supporting evidence-based adolescent health, and who has spoken about her own closeted trans youth, her confirmation marks a sea change from the right-wing <a href="https://equityfwd.org/rewire-abstinence-advocate-previously-cited-neglect-duty-tapped-create-hhs-strategies">political activists appointed to OASH</a> under former President Donald Trump.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CWAvwy">
Because of the historic nature of Levine’s appointment, there has been much talk about her trans identity. Meanwhile, her qualifications, which should not be overshadowed, have taken a back seat. For the last three years, she’s been the secretary of health for Pennsylvania, where she has taken the lead on the state’s handling of the Covid-19 pandemic. Her clear-eyed press conferences instructing Pennsylvanians on how to survive the pandemic have earned praise from Democrats inside the state. Before she became the secretary of health, she was the state’s physician general.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JHCNSZ">
Levine frequently takes a holistic approach to policy, <a href="https://www.phillymag.com/news/2020/07/16/rachel-levine-pennsylvania-health/">telling Philadelphia magazine</a> last July how she conceptualizes public health. “Economic opportunity is health. A living wage with an increase in the minimum wage is actually health,” she said. “Improving educational opportunities, improving nutrition, improving the environment, improving transportation for people is health. Getting rid of racism is health.”
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Following President Joe Biden’s nomination, Pennsylvania Gov. Tom Wolf called Levine “a highly skilled and valued member of my administration.”
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“She has been a wise and dedicated partner during this pandemic and throughout her career with the commonwealth,” <a href="https://www.governor.pa.gov/newsroom/gov-wolf-congratulates-thanks-dr-levine-following-nomination-by-president-elect-biden/">Wolf said in a statement</a>. “I couldn’t be prouder of the tireless work she’s done to serve Pennsylvanians and protect the public health.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LdG8rR">
Levine’s confirmation would be important, if only because she would instantly become a recognizable and authoritative trans voice on public health at a moment when access to trans health care is increasingly threatened worldwide. With Biden taking an explicitly pro-trans stance, Levine steps into a visible role in charge of federal youth health policy.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ylA6Te">
“This marks a real turning point that honors and includes trans people,” Molly Bangs, director of Equity Forward, an HHS watchdog group, told Vox about Levine’s nomination in January. “She’s given every indication that she will continue to center equity from all perspectives when ascending to federal office. Transgender youth need real quality health care and access to information more so than ever. She’s demonstrated that that is very much a cornerstone of really what drives her career.”
</p>
<h3 id="4LPr1g">
Levine takes over a key federal public health office in a pivotal moment
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DIFKjQ">
Her most immediate demand as assistant secretary of health is likely to be helping manage the federal government’s handling of the pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mSLUlm">
But beyond the pandemic, she will take over a department that underwent some radical changes under Trump. The Office for Women’s Health and the Office of Population Affairs oversee most of the government’s reproductive health initiatives. The transition from Obama to Trump saw progressive initiatives tossed out in favor of anti-reproductive health policies, including rolling back the <a href="https://www.vox.com/21421292/trump-free-birth-control-iud-health-care">Obamacare birth control mandate</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B2wiO7">
Meanwhile, the Office of Adolescent Health, which administered the Teen Pregnancy Prevention Program, was <a href="https://rewirenewsgroup.com/article/2019/04/04/the-trump-administration-wants-to-give-anti-choice-official-more-power-over-reproductive-health-programs/">shunted to a different office’s oversight</a> and essentially shuttered under Trump. One of Levine’s first accomplishments in Pennsylvania was establishing the state’s Office of Adolescent Health, and she’ll now be tasked with restoring that office at the federal level
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="stwkVt">
“This position of assistant secretary of health has a massive portfolio of issues,” said Bangs. “Dr. Levine and her colleagues will have their work cut out for them, and they will need a really proactive agenda in order to not just reverse the damage that’s been done but also protect and expand LGBTQ rights [and] sexual and reproductive health [access].”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VvyPvu">
That work will get underway almost immediately. Even before Levine’s confirmation hearing was scheduled, the Biden administration took initial steps to overturn Trump policy at OASH. The White House has already launched a review of the <a href="https://www.vox.com/policy-and-politics/2019/2/22/18236227/abortion-planned-parenthood-gag-rule-title-x">Title X domestic gag rule</a> — which banned federal funding to health clinics that perform or refer patients for abortions.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CT712g">
Levine’s office will oversee the review, putting her at the center of US reproductive health policy for the next several years.
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<h3 id="WFiua9">
Levine will not be the first openly trans government official
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uzzfLJ">
Though she is deeply qualified for the position, Levine’s trans identity has grabbed the lion’s share of media attention.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K29J7Z">
Newspapers and websites have trumpeted her identity, almost to the exclusion of any other facts about her. “Biden picks 1st transgender person for Senate-confirmed post,” read an <a href="https://apnews.com/article/rachel-levine-health-secretary-4eee53439e9c2b4c27fcf4e7f572cb0e">Associated Press headline</a> in January. Even the LGBTQ Nation’s <a href="https://www.lgbtqnation.com/2021/01/joe-biden-picks-transgender-woman-assistant-health-secretary/">headline</a> — “Joe Biden picks transgender woman for assistant health secretary” — did not mention Levine by name.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="q5agjd">
While Levine is now the highest-ranking transgender official in the federal government, a welcome step forward for a community that has historically had very little institutional power, she is not the first openly trans government official appointed by a president; she is just the first to be confirmed by the Senate. President Barack Obama named trans woman <a href="https://abcnews.go.com/Politics/amanda-simpson-transgender-presidential-appointee-begins-work-commerce/story?id=9477161">Amanda Simpson</a> senior technical adviser in the Commerce Department’s Bureau of Industry and Security in 2010, though it was not a Senate-confirmed appointment.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZEem2y">
Levine’s trans identity will inform her new role as one of the nation’s top public health officials.<strong> </strong>“At a time when access to health care is a growing crisis for transgender people made worse by anti-LGBTQ legislation and legislators across the nation, Dr. Levine has the empathy to understand the health needs of our diverse country and the skillset to improve them,” Alphonso David, president of the Human Rights Campaign, has <a href="https://www.hrc.org/press-releases/human-rights-campaign-on-the-historic-nomination-of-dr-dr-rachel-levine-to-be-assistant-health-secretary">said in a statement</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2MKw11">
Levine has spoken previously about her experiences as a closeted trans child. At a conference in 2015, just after she’d been appointed Pennsylvania’s acting physician general, she described growing up playing football and hockey near Boston in the ’60s, but also carrying with her a deep secret. ”All I knew is I wanted to be a girl, or I was a girl, or female,” <a href="https://www.pennlive.com/midstate/2015/03/transgender_conference_rachel.html">she told a crowd</a> in Swatara Township, Pennsylvania.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UxTu5M">
During that conference, Levine spoke directly to the state’s trans youth. “What I want to tell those kids is I am there for you. We are here for you,” she said. “Please don’t harm yourself and please don’t despair, because we are there for you.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ejyN9E">
It’s a message she’s continued to stand by throughout her public health career, even as critics and random internet trolls relentlessly attacked her gender identity and appearance. And she’s making history in a time and place when trans “firsts” are becoming rarer — an appointment that is as much a win for trans people as it is for a well-qualified doctor with a lifetime of public health experience.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>National Para Athletics hits a new low as night events held under mobile phone torch lights</strong> - A few events at night conducted with just mobile phone torch lights</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Torch relay for Tokyo Olympics kicks off its 121-day journey</strong> - The ceremony was closed to the public because of the fear of spreading COVID-19 but was streamed live.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Norway players make Qatar protest in World Cup qualifier</strong> - Norway have one of their best chances in recent memory to qualify for the World Cup for the first time since 1998.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India seeks to play fearless football</strong> - Takes on Oman in first international after COVID-19 lockdown</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bhavani set to resume training at Livorno</strong> - India’s star fencer Bhavani Devi is all set to resume training at Livorno (Italy) with coach Nicola Zanotti for the Tokyo Olympics.“I will be leaving</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘Farrago of venomous claims on love jihad’: Shashi Tharoor on BJP’s Kerala manifesto</strong> - “The only consolation is that they will never be in a position to implement any of it,” the MP from Thiruvananthapuram said.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Campaign ends for first phase of poll in West Bengal</strong> - Curtains came down at 5 pm on Thursday on the high decibel campaign in 30 assembly seats in West Bengal where polls are scheduled in the first phase</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hate crime proceedings against Patricia Mukhim quashed</strong> - SC agrees with Editor of Shillong Times that her social media post was only an expression of truth</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bengal tops in Facebook political ad spend among poll-bound states</strong> - Political parties of West Bengal spent about ₹ 3.74 crore on poll-related campaigns which fall under Facebook’s advertisement category.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Parliament passes Bill to set up National Bank for Financing Infrastructure and Development</strong> - Parliament on Thursday passed a Bill to set up the National Bank for Financing Infrastructure and Development (NaBFID) to fund infrastructure project</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid-19: Merkel defends rollout as vaccine pressure grows</strong> - German Chancellor Angela Merkel defends the EU’s decision to procure coronavirus vaccines jointly.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Daniel Guerini: Lazio youth-team midfielder dies aged 19</strong> - Lazio say they are “shocked by pain” following the death of 19-year-old youth-team midfielder Daniel Guerini.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nagorno-Karabakh: The mystery of the missing church</strong> - The BBC investigates the disappearance of an Armenian church that changed hands in the recent Nagorno-Karabakh war.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nice catch: Fisherman rescues boy stranded on ice</strong> - A fisherman in Ukraine reels in a boy who was stranded on a block of ice in a river.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Julie Pomagalski, French former snowboard world champion, dies in Swiss avalanche</strong> - Julie Pomagalski, 40, was swept away while skiing off-piste on a mountain in Switzerland.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>After dramatic rebuke, AstraZeneca lowers vaccine efficacy estimate—a little</strong> - Independent experts called the earlier analysis “outdated and potentially misleading.” - <a href="https://arstechnica.com/?p=1752082">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>It’s been 20 years since the launch of Mac OS X</strong> - It’s macOS 11 now, but the DNA is the same. - <a href="https://arstechnica.com/?p=1751974">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Facebook shuts down hackers who infected iOS and Android devices</strong> - Social media platform used to spread malware that spied on Uyghurs. - <a href="https://arstechnica.com/?p=1752030">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Former Trump vaccine czar fired over substantiated sexual harassment claim</strong> - GSK hired a law firm for an investigation, which substantiated the claims. - <a href="https://arstechnica.com/?p=1752031">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Having it all: Protecting biodiversity, carbon capture, and fish stocks</strong> - Researchers scan the world’s oceans to find ideal locations for protection. - <a href="https://arstechnica.com/?p=1751997">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A man takes a pleasant stroll on a Friday evening… suddenly, the Devil himself pops up in front of him</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
and whispers, “Take all the money in your wallet, go to this casino, and put them on the number 27!”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man is first shocked, then becomes curious, and quickly yields, goes to the casino, puts all the money on 27 and wins!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Excited he exists the casino and meets the Devil again. The latter is silent for a moment and then says again, “Take all your money - all that you’ve won - go inside and put them on 27!” - “Again?!” - “Yes! Do it!” - The man quickly yields, goes in again, puts all the money on 27 and … wins!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Now everyone in the casino is amazed, they check the wheel, nope no tilt or bias (and it was outputting numbers randomly before), seems like genuine luck, reluctantly he’s given almost two hundred thousand dollars and leaves elated. Outside he meets the Devil again who again tells him to go put everything on 27, the man is shocked but does so, and wins again!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
And now he’s given most of the casino’s bank, millions of dollars, walks out shining like a star, and says to the Devil, “I don’t know why people say you’re the most sinister being there is, you’ve been awesome to me today!!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Devil looks at him strangely, pauses, and replies, “Well that may be true or not but you are definitely the luckiest motherfucking son of a bitch that I’ve ever fucking seen!!”
</p>
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Laroel"> /u/Laroel </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mcmofw/a_man_takes_a_pleasant_stroll_on_a_friday_evening/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mcmofw/a_man_takes_a_pleasant_stroll_on_a_friday_evening/">[comments]</a></span></p></li>
<li><strong>The other day my wife told me some woman at work called her fat</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I told her “Honey, don’t fight with her about it. Just be the bigger person.”
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So anyway now I’m divorced
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/WannaHearALimerick"> /u/WannaHearALimerick </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mclfyh/the_other_day_my_wife_told_me_some_woman_at_work/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mclfyh/the_other_day_my_wife_told_me_some_woman_at_work/">[comments]</a></span></p></li>
<li><strong>My uncle bought a piano from Nigeria.</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
So he brings it home and hires a guy to come tune it. The piano tuner struggles with it and after five minutes says, “Lemme guess… West African piano?”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Yeah, how did you know?” my uncle responds.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Well, West African pianos are notoriously hard to tune,” he says, “not like North African pianos, they Tunisia “
</p>
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/soft-scrambled"> /u/soft-scrambled </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mc6ywp/my_uncle_bought_a_piano_from_nigeria/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mc6ywp/my_uncle_bought_a_piano_from_nigeria/">[comments]</a></span></p></li>
<li><strong>Two fish are in a tank. One turns to the other and says</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Okay, you man the guns. I’ll drive.”
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/summerofevidence"> /u/summerofevidence </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mcfu2i/two_fish_are_in_a_tank_one_turns_to_the_other_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mcfu2i/two_fish_are_in_a_tank_one_turns_to_the_other_and/">[comments]</a></span></p></li>
<li><strong>Jersey must be a real shithole</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
If New Jersey was meant to be an improvement.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/edfitz83"> /u/edfitz83 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mck1dw/jersey_must_be_a_real_shithole/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mck1dw/jersey_must_be_a_real_shithole/">[comments]</a></span></p></li>
</ul>
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