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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Risk perception, Unhealthy Behavior, and Anxiety due to Viral Epidemic among Healthcare Workers: The Relationships with Depressive and Insomnia symptoms during COVID-19</strong> -
<div>
We aimed to investigate the relationship between mental health problems and unhealthy behaviors among healthcare workers in response to the COVID-19 pandemic. Using an online survey, we collected data on healthcare workers’ perception regarding COVID-19 exposure in a work unit. Workers’ depression, insomnia, and anxiety symptoms were assessed using the Patient Health Questionnaire-9, Insomnia Severity Index, and Generalized Anxiety Disorder-7 scale, respectively. Work-related stress and anxiety in response to the viral epidemic were measured using the Stress and Anxiety to Viral Epidemic-9 (SAVE-9) scale. We found that work-related stress and anxiety in response to the viral epidemic was associated with female sex, perception of the workplace as being dangerous, and depressive symptoms. Unhealthy behaviors, such as smoking and drinking as coping behaviors during the pandemic, were associated with male sex, young age, depression, and insomnia. During the COVID-19 pandemic, it is necessary to closely observe the patterns of work-related stress and anxiety reactions among healthcare workers to reduce their burnout.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/ph3ny/" target="_blank">Risk perception, Unhealthy Behavior, and Anxiety due to Viral Epidemic among Healthcare Workers: The Relationships with Depressive and Insomnia symptoms during COVID-19</a>
</div></li>
<li><strong>Does serotonin deficiency lead to anosmia, ageusia and dysfunctional chemesthesis?</strong> -
<div>
Anosmia, ageusia and impaired chemesthetic sensations are quite common in coronavirus patients. Different mechanisms have been proposed to explain the anosmia and ageusia of COVID-19 patients, though for reversible anosmia and ageusia, which are quickly resolved, the proposed mechanisms seem to be incomplete. In addition, the reason behind the impaired chemesthetic sensations of some coronavirus patients remains unknown. It is proposed that in coronavirus patients, there is depletion of tryptophan (an essential amino acid), as ACE2, a key element in the process of absorption of tryptophan from food, is significantly reduced by the attack of coronavirus which use ACE2 as the receptor for its entry into the host cells. Incidentally, the depletion of tryptophan should lead to deficiency of serotonin (5-HT) in SARS-COV-2 patients because tryptophan is the precursor in the synthesis of 5-HT. Such 5-HT deficiency not only explains fast resolved anosmia and ageusia, but also dysfunctional chemesthesis, given the fact that 5-HT is an important neuromodulator in the olfactory neurons and taste receptor cells and 5-HT also enhances the nociceptor activity of transient receptor potential channels (TRP channels) responsible for chemesthetic sensations. The female predominance of olfactory and gustatory dysfunctions can also be explained by considering low 5-HT levels in women. In addition, 5-HT deficiency worsens silent hypoxemia and explains why hypoxic pulmonary vasoconstriction is nearly absent in coronavirus patients leading to poor outcome. Hence, clinical trials should be conducted on coronavirus patients to find out how different selective serotonin reuptake inhibitors (SSRIs) and serotonin agonists work out in eliminating or improving the olfactory, gustatory and chemesthetic dysfunctions as well as hypoxemia.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/xybh2/" target="_blank">Does serotonin deficiency lead to anosmia, ageusia and dysfunctional chemesthesis?</a>
</div></li>
<li><strong>Social inequities in the impact of COVID-19 lockdown measures on the mental health of a large sample of the Colombian population (PSY-COVID study)</strong> -
<div>
Background. The identification of general population groups particularly vulnerable to the impact of COVID-19 lockdown measures on mental health and the development of healthcare policies are priority challenges in the current and future pandemics. Objective. To identify the personal and social determinants of the impact of COVID-19 lockdown measures on mental health in a large sample of the Colombian population. Design. In this cross-sectional study, an anonymous online survey was answered by 18,061 participants from the general population residing in Colombia during the first wave of the COVID-19 outbreak (from May 20th to June 20th, 2020). Main outcome measures. Symptoms of depression, anxiety, and somatisation were measured using the Patient Health Questionnaire (PHQ-2), Generalized Anxiety Disorder Scale (GAD-2), and Somatic Symptom Questionnaire (SSQ-5), respectively. Results. Overall, 35% of participants showed symptoms of depression, 29% of anxiety, and 31% of somatization. According to the analysis of social determinants of health, the most affected groups were people with low incomes, students, and young adults. Specifically, low-income young females were the most at-risk population group. Conclusion. These findings show how the lockdown measures impacted on the general population’s mental health in Colombia and highlights some social risk factors in health.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/bt9p2/" target="_blank">Social inequities in the impact of COVID-19 lockdown measures on the mental health of a large sample of the Colombian population (PSY-COVID study)</a>
</div></li>
<li><strong>Change in mental and physical health, and social relationships, during highly restrictive lockdown in the COVID-19 pandemic: Evidence from Australia</strong> -
<div>
Background. A novel coronavirus first reported in Wuhan City in China in 2019 (COVID-19) developed into a global pandemic throughout 2020. Many countries around the world implemented strict social distancing policies to curb the spread of the virus. In this study we aimed to examine potential change in mental/physical health and social relationships during a highly restrictive COVID-19 lockdown period in Australia during April 2020. Methods. Our survey (n = 1599) included questions about concerns, social behaviour, perceived change in relationship quality, social media use, frequency of exercise, physical health, and mental health during COVID-19 lockdown (April, 2020). Results. When estimating their mental health for the previous year 13% of participants reported more negative than positive emotion, whereas this increased to 41% when participants reflected on their time during COVID-19 lockdown. A substantial proportion (39-54%) of participants reported deterioration in mental health, physical health, financial situation, and work productivity. However, most of these participants reported ‘somewhat’ rather than ‘a lot’ of deterioration, and many others reported ‘no change’ (40-50%) or even ‘improvement’ (6-17%). Therefore, the psychological toll on Australians may not have been as large as other parts of the world with greater COVID-19 infection rates. Even less impact was apparent for social relationships (~68% reported ‘no change’) as participants compensated for decreased face-to-face interaction via increased technology-mediated interaction. Our findings highlight how technology-mediated communication can allow people to adequately maintain social relationships during an extreme lockdown event.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/zutav/" target="_blank">Change in mental and physical health, and social relationships, during highly restrictive lockdown in the COVID-19 pandemic: Evidence from Australia</a>
</div></li>
<li><strong>SARS-CoV-2 variants B.1.351 and B.1.1.248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination</strong> -
<div>
The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the COVID-19 pandemic. However, recently emerged SARS-CoV-2 variants B.1.1.7 (UK), B.1.351 (South Africa) and B.1.1.248 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies. Here, using pseudoparticles, we show that entry of UK, South Africa and Brazil variant into human cells is susceptible to blockade by entry inhibitors. In contrast, entry of the South Africa and Brazil variant was partially (Casirivimab) or fully (Bamlanivimab) resistant to antibodies used for COVID-19 treatment and was less efficiently inhibited by serum/plasma from convalescent or BNT162b2 vaccinated individuals. These results suggest that SARS-CoV-2 may escape antibody responses, which has important implications for efforts to contain the pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.02.11.430787v1" target="_blank">SARS-CoV-2 variants B.1.351 and B.1.1.248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination</a>
</div></li>
<li><strong>Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response</strong> -
<div>
Key immune signatures of SARS-CoV-2 infection may associate with either adverse immune reactions (severity) or simply an ongoing anti-viral response (temporality); how immune signatures contribute to severe manifestations and/or temporal progression of disease and whether longer disease duration correlates with severity remain unknown. Patient blood was comprehensively immunophenotyped via mass cytometry and multiplex cytokine arrays, leading to the identification of 327 basic subsets that were further stratified into more than 5000 immunotypes and correlated with 28 plasma cytokines. Low-density neutrophil abundance was closely correlated with hepatocyte growth factor levels, which in turn correlated with disease severity. Deep analysis also revealed additional players, namely conventional type 2 dendritic cells, natural killer T cells, plasmablasts and CD16+ monocytes, that can influence COVID-19 severity independent of temporal progression. Herein, we provide interactive network analysis and data visualization tools to facilitate data mining and hypothesis generation for elucidating COVID-19 pathogenesis.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.02.10.430668v1" target="_blank">Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response</a>
</div></li>
<li><strong>Combinatorial analysis of phenotypic and clinical risk factors associated with hospitalized COVID-19 patients</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Characterization of the risk factors associated with variability in the clinical outcomes of COVID-19 is important. Our previous study using genomic data identified a potential role of calcium and lipid homeostasis in severe COVID-19. This study aimed to identify similar combinations of features (disease signatures) associated with severe disease in a separate patient population with purely clinical and phenotypic data. The PrecisionLife combinatorial analytics platform was used to analyze features derived from de-identified health records in the UnitedHealth Group COVID-19 Data Suite. The platform identified and analyzed 836 disease signatures in two cohorts associated with increased risk of COVID-19 hospitalization. Cohort 1 was formed of cases hospitalized with COVID-19 and a set of controls who developed mild symptoms. Cohort 2 included Cohort 1 individuals for whom additional laboratory test data was available. We found several disease signatures where lower levels of lipids were found co-occurring with lower levels of serum calcium and leukocytes. Many of the low lipid signatures were independent of statin use and 50% of cases with hypocalcemia signatures were reported with vitamin D deficiency. These signatures may be attributed to similar mechanisms linking calcium and lipid signaling where changes in cellular lipid levels during inflammation and infection affect calcium signaling in host cells. This study and our previous genomics analysis demonstrate that combinatorial analysis can identify disease signatures associated with the risk of developing severe COVID-19 separately from genomic or clinical data in different populations. Both studies suggest associations between calcium and lipid signalling in severe COVID-19.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.08.21250899v1" target="_blank">Combinatorial analysis of phenotypic and clinical risk factors associated with hospitalized COVID-19 patients</a>
</div></li>
<li><strong>Implementation of an in-house real-time reverse transcription-PCR assay to detect the emerging SARS-CoV-2 N501Y variants</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The real-time detection of emerging SARS-CoV-2 variants is critical to manage patients appropriately, and monitor and assess their epidemiological and clinical features. Sequencing is not a feasible comprehensive detection strategy considering the very large number of SARS-CoV-2 cases in our current setting. SARS-CoV-2 variants currently of greatest concern carry the N501Y substitution within the spike receptor binding domain. They have become predominant in England (20I/501Y.V1) and were detected in South Africa (20H/501Y.V2), Brazil and dozens of other countries worldwide. The 20I/501Y.V1 variant has started to spread worldwide including in France. It has been reported as 50-74% more transmissible than preexisting strains, suspected to evade anti-spike antibodies, and it caused a reinfection. We have implemented an in-house one-step real-time reverse transcription-PCR (qPCR) assay that specifically detects SARS-CoV-2 N501Y. It was found reliable to detect specifically the N501Y substitution and preliminarily allowed estimating 20I/501Y.V1 variant prevalence to 4% among our current SARS-CoV-2 diagnoses since January.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.03.21250661v1" target="_blank">Implementation of an in-house real-time reverse transcription-PCR assay to detect the emerging SARS-CoV-2 N501Y variants</a>
</div></li>
<li><strong>Hospitalizations, resource use and outcomes of acute pulmonary embolism in Germany during the Covid-19 pandemic - Emergence of different phenotypes of thrombotic disease?</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: There is discussion evolving around the emergence of different phenotypes of Covid-19-associated thromboembolic disease, i.e. acute pulmonary embolism vs pulmonary thrombosis and different phenotypes of in situ thrombosis. With this study, we wish to provide hospitalization, treatment and in-hospital outcome data for pulmonary embolism during the 2020 Covid-19 pandemic and a corresponding 2016-2019 control period. Methods: We performed a retrospective analysis of claims data of Helios hospitals in Germany. Consecutive cases with a hospital admission between January 1 and December 15, 2020 and pulmonary embolism as primary discharge diagnosis were analyzed and compared to a corresponding period covering the same weeks in 2016-2019. Results: As previously reported for other emergent medical conditions, there was a hospitalization deficit coinciding with the 1st pandemic wave. Beginning with the 12-week interval May 6 - July 28, there was a stable surplus of hospital admissions in 2020. During this surplus period (May 6 - December 15, 2020), there were 2,449 hospitalizations including 45 PCR-confirmed Covid-19 cases (1.8%) as opposed to 8,717 in 2016-2019 (IRR 1.12, 95% CI 1.07-1.18, P&lt;0.01). When excluding Covid-19 cases IRR was 1.10 (95% CI 1.05-1.15, P&lt;0.01). While overall comorbidities expressed as weighted AHRQ Elixhauser Comorbidity Index (14.1+/-10.1 vs. 13.9+/-10.3, P=0.28), the presence of thrombosis (46.1 vs 45.4%, P=0.55) and surgery (3.8 vs. 4.3%, P=0.33) were comparable, coagulopathy (3.3 vs 4.5%, P=0.01) and metastatic cancer (3.0 vs 4.0%, P=0.03) as contributing factors were less frequently observed during the 2020 surplus. Interventional treatments (thrombolytic therapy, thrombectomy or inferior vena cava filter placement) were less frequently used (4.7 vs 6.6%, OR 0.72, 95% CI 0.58-0.89, P&lt; 0.01). Similarly, intensive care (35.1 vs 38.8%, OR 0.83, 95% CI 0.75-0.92, P&lt; 0.01) and mechanical ventilation utilization (7.2 vs 8.1%, OR 0.88, 95% CI 0.74-1.04, P=0.14) as well as in-hospital-mortality rates (7.8 vs 9.8%, OR 0.76, 95% CI 0.64-0.90, P&lt; 0.01) were lower in 2020 compared with 2016-2019. This was associated with a shorter length of hospital stay (6.4+/-5.4 vs. 7.2+/-5.7 days, P&lt; 0.01) during the 2020 surplus period. Conclusions: Only a minority of cases were associated with PCR-confirmed Covid-19 but this does not rule out preceding or undetected SARS-CoV-2 infection. Although there is a shift towards milder disease course, the increased incidence of hospitalizations for pulmonary embolism requires immediate attention, close surveillance and further studies.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.08.21250291v1" target="_blank">Hospitalizations, resource use and outcomes of acute pulmonary embolism in Germany during the Covid-19 pandemic - Emergence of different phenotypes of thrombotic disease?</a>
</div></li>
<li><strong>Association of state social distancing restrictions with nursing home COVID-19 and non-COVID-19 outcomes</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The COVID-19 poses a disproportionate threat to nursing home residents. Although recent studies suggested the effectiveness of state social distancing measures in the United States on curbing COVID-19 morbidity and mortality among the general population, there is lack of evidence as to how these state orders may have affected nursing home patients or what potential negative health consequences they may have had. In this longitudinal study, we evaluated changes in state strength of social distancing restrictions from June to August of 2020, and their associations with the weekly numbers of new COVID-19 cases, new COVID-19 deaths, and new non-COVID-19 deaths in nursing homes of the US. We found that stronger state social distancing measures were associated with improved COVID-19 outcomes (case and death rates), reduced across-facility disparities in COVID-19 outcomes, but more deaths due to non-COVID-19 reasons among nursing home residents.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.08.21251382v1" target="_blank">Association of state social distancing restrictions with nursing home COVID-19 and non-COVID-19 outcomes</a>
</div></li>
<li><strong>Hospitalizations for emergency-sensitive conditions in Germany during the Covid-19 pandemic - Insights from the German-wide Helios hospital network</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: While there are numerous reports that describe emergency care during the early Covid-19 pandemic, there is scarcity of data for later stages. This study analyzes hospitalization rates for 37 emergency-sensitive conditions in the largest German-wide hospital network during different pandemic phases. Methods: Using claims data of 80 hospitals, consecutive cases between January 1 and November 17, 2020 were analyzed and compared to a corresponding period in 2019. Incidence-rate ratios (IRR) comparing the both periods were calculated using Poisson regression to model the number of hospitalizations per day. Results: There was a hospitalization deficit between March 12 and June 13, 2020 (coinciding with the 1st pandemic wave) with 32,807 hospitalizations as opposed to 39,379 in 2019 (IRR 0.83, 95% CI 0.82-0.85, P&lt;0.01). During the following period (June 14 to November 17, 2020, including the start of 2nd wave), hospitalizations were reduced from 63,799 in 2019 to 59,910 in 2020, but this reduction was not that pronounced (IRR 0.94, 95% CI 0.93-0.95, P&lt;0.01). There was an increase in hospitalizations for acute myocardial infarction, aortic aneurism/dissection and pulmonary embolism after the 1st wave during which hospitalizations had been reduced for those conditions. In contrast, hospitalizations for sepsis, pneumonia, obstructive pulmonary disease, and intracranial injuries were reduced during the entire pandemic. Conclusions: There was an overall reduction of hospitalizations for emergency-sensitive conditions in Germany during the Covid-19 pandemic with heterogeneous effects on different disease categories. The increase of hospitalizations for acute myocardial infarction, aortic aneurism/dissection and pulmonary embolism is an alarming signal that requires attention and further studies.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.08.21250309v1" target="_blank">Hospitalizations for emergency-sensitive conditions in Germany during the Covid-19 pandemic - Insights from the German-wide Helios hospital network</a>
</div></li>
<li><strong>SARS-CoV-2 Seroprevalence Among Antenatal Clinic Attendees in Kingston, Jamaica, September-November 2020</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
SARS-CoV-2 seroprevalence in an antenatal population in Kingston, Jamaica was assessed for September-November 2020 in a repeated cross-sectional study using the Abbott Architect SARS-CoV-2 IgG assay. After adjusting for test performance, seroprevalence was 6.9% for September, 16.9% for October, and 24.0% for November. Of the 37 pregnant women testing SARS-CoV-2 IgG positive, only 3 were symptomatic. One symptomatic woman testing SARS-CoV-2 IgG positive had multiple co-morbidities and succumbed to COVID-19 pneumonia. Up to January 31, 2021, 8 women identified as SARS-CoV-2 IgG positive delivered, all without complications. Comparison of test adjusted seroprevalence data with cumulative PCR-confirmed COVID-19 cases within the Kingston Metropolitan Area indicated that as many as 44.4 times more people were infected with SARS-CoV-2 than identified with PCR testing. These findings provide the first evidence for the extent of SARS-CoV-2 infections in Jamaica and will inform future SARS-CoV-2 testing strategies.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.08.21251367v1" target="_blank">SARS-CoV-2 Seroprevalence Among Antenatal Clinic Attendees in Kingston, Jamaica, September-November 2020</a>
</div></li>
<li><strong>Estimating real-world COVID-19 vaccine effectiveness in Israel</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The vaccination rollout of the COVID-19 in Israel has been highly successful compared to all other countries. By the end of January, a third of the population has already been administered at least one dose of the BNT162b2 vaccine. Efforts to estimate the true real-world effectiveness of the vaccine have been hampered by disease dynamics and social-economic discrepancies. Here, using counts of positive and hospitalized cases of vaccinated individuals, we provide sensitive estimations of the vaccine effectiveness by correcting to daily case incidence. We find high effectiveness of 66-85% in reducing SARS-CoV-2 positive cases and over 90% in reducing severe hospitalizations. As more granular data will be available more it will be possible to extract more exact estimates; however, there is little doubt that the vaccine is highly effective in reducing cases, hospitalizations and deaths.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.05.21251139v1" target="_blank">Estimating real-world COVID-19 vaccine effectiveness in Israel</a>
</div></li>
<li><strong>Country specific mutational profile of SARS-CoV-2 in pre- and post-international travel ban: Effect on vaccine efficacy</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In order to curb the rapid transmission of SARS-CoV-2, nation-wide lockdowns were implemented as a preliminary measure. Since most countries enforced travel-bans during end of March 2020, the country-specific patterns should be discernible in the subsequent months. We identified frequently mutated non-synonymous mutations in 2,15,000 SARS-CoV-2 sequences during pre and post-travel-ban periods in 35 countries. We further investigated the mutational profile on a bi-monthly basis and traced the progress over the time. Several new mutations have emerged post-travel-ban and on the rise in specific countries, chief among them being A222V and S477N in Spike, and A220V in Nucleocapsid protein. Consequently, we examined the Spike protein epitopes to inspect whether any of these country-specific mutations overlapped with these epitopes. Several mutations were found to be contained within one or more epitopes, including the highly mutated residues of Spike protein, advocating the requirement of active monitoring of vaccine efficacies in respective countries.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.08.21251359v1" target="_blank">Country specific mutational profile of SARS-CoV-2 in pre- and post-international travel ban: Effect on vaccine efficacy</a>
</div></li>
<li><strong>Before the Surge: Molecular Evidence of SARS-CoV-2 in New York City Prior to the First Report</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
New York City (NYC) emerged as a coronavirus disease 2019 (COVID-19) epicenter in March 2020, but there is limited information regarding potentially unrecognized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections before the first reported case. We utilized a sample pooling strategy to screen for SARS-CoV-2 RNA in de-identified, respiratory pathogen-negative nasopharyngeal specimens from 3,040 patients across our NYC health system who were evaluated for respiratory symptoms or influenza-like illness during the first 10 weeks of 2020. We obtained complete SARS-CoV-2 genome sequences from samples collected between late February and early March. Additionally, we detected SARS-CoV-2 RNA in pooled specimens collected in the week ending 25 January 2020, indicating that SARS-CoV-2 caused sporadic infections in NYC a full month before the first officially documented case.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.08.21251303v1" target="_blank">Before the Surge: Molecular Evidence of SARS-CoV-2 in New York City Prior to the First Report</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Safety and Efficacy of a Single Dose of STI-2020 (COVI-AMG™) to Treat COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: COVI-AMG;   Drug: Placebo<br/><b>Sponsor</b>:   Sorrento Therapeutics, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate a Single Dose of STI-2020 (COVI-AMG™) in Adults With Mild COVID-19 Symptoms</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: COVI-AMG;   Drug: Placebo<br/><b>Sponsor</b>:   Sorrento Therapeutics, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An Effectiveness Study of the Sinovac’s Adsorbed COVID-19 (Inactivated) Vaccine</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: Adsorbed COVID-19 (Inactivated) Vaccine<br/><b>Sponsor</b>:   Butantan Institute<br/><b>Enrolling by invitation</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Telerehabilitation in Covid-19 After Hospital Discharge</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Standard Physiotherapy program;   Other: Telerehabilitation<br/><b>Sponsor</b>:   Universidad de Granada<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TOCILIZUMAB - An Option for Patients With COVID-19 Associated Cytokine Release Syndrome; A Single Center Experience</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Tocilizumab<br/><b>Sponsor</b>:   FMH College of Medicine and Dentistry<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Convalescent Plasma in the Treatment of Covid-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Convalescent plasma from COVID-19 donors;   Biological: Placebo<br/><b>Sponsors</b>:   Helsinki University Central Hospital;   Finnish Red Cross<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of the Kinetics of COVID-19 Antibodies for 24 Months in Patients With Confirmed SARS-CoV-2 Infection</strong> - <b>Conditions</b>:   Covid19;   SARS-CoV 2<br/><b>Intervention</b>:   Other: Sampling by venipuncture<br/><b>Sponsor</b>:   Centre Hospitalier Régional d’Orléans<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Efficacy and Safety of VB-201 in Patients With COVID-19</strong> - <b>Condition</b>:   Severe COVID-19<br/><b>Interventions</b>:   Drug: VB-201 + Standard of care;   Drug: Standard of care<br/><b>Sponsor</b>:   Vascular Biogenics Ltd. operating as VBL Therapeutics<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Convalescent Plasma Therapy</strong> - <b>Conditions</b>:   SARS-CoV-2 Infection;   COVID-19 Infection<br/><b>Intervention</b>:   Biological: Convalescent plasma<br/><b>Sponsors</b>:   Angelica Samudio;   Consejo Nacional de Ciencias y Tecnología, Paraguay;   Ministerio de Salud Pública y Bienestar Social, Paraguay;   Centro de información y recursos para el desarrollo, Paraguay<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Oxidative Stress Parameters, Trace Element and Quality of Life in Women Before and After Covid-19 Vaccines</strong> - <b>Condition</b>:   Covid-19 Vaccine<br/><b>Intervention</b>:   Biological: CoronoVac Vaccine<br/><b>Sponsors</b>:   Izmir Bakircay University;   Cigli Regional Training Hospital;   Muğla Sıtkı Koçman University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients</strong> - <b>Condition</b>:   Covid-19<br/><b>Interventions</b>:   Drug: CPI-006 2 mg/kg + SOC;   Drug: CPI-006 1 mg/kg + SOC;   Drug: Placebo + SOC<br/><b>Sponsor</b>:   Corvus Pharmaceuticals, Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Ivermectin<br/><b>Sponsor</b>:   FMH College of Medicine and Dentistry<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Assess Efficacy and Safety of Inhaled Interferon-β Therapy for COVID-19</strong> - <b>Conditions</b>:   Severe Acute Respiratory Syndrome Coronavirus 2;   COVID-19<br/><b>Interventions</b>:   Drug: SNG001;   Drug: Placebo<br/><b>Sponsor</b>:   Synairgen Research Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AGILE (Early Phase Platform Trial for COVID-19)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: CST-2: EIDD-2801;   Drug: CST-2: Placebo<br/><b>Sponsors</b>:   University of Liverpool;   University of Southampton;   Liverpool School of Tropical Medicine;   Lancaster University;   Liverpool University Hospitals NHS Foundation Trust<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Efficacy and Safety of Prothione™ Capsules for Mild to Moderate Coronavirus Disease 2019 (COVID-19)</strong> - <b>Condition</b>:   Coronavirus Disease 2019 (COVID-19)<br/><b>Interventions</b>:   Drug: Placebo;   Drug: Prothione™ (6g)<br/><b>Sponsor</b>:   Prothione, LLC<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2</strong> - An efficient treatment against a COVID-19 disease, caused by the novel coronavirus SARS-CoV-2 (CoV2), remains a challenge. The papain-like protease (PL^(pro)) from the human coronavirus is a protease that plays a critical role in virus replication. Moreover, CoV2 uses this enzyme to modulate the host’s immune system to its own benefit. Therefore, it represents a highly promising target for the development of antiviral drugs. We used Approximate Bayesian Computation tools, molecular modelling and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses</strong> - The synthesis of α-fluorinated methyl ketones has always been challenging. New methods based on the homologation chemistry via nucleophilic halocarbenoid transfer, carried out recently in our labs, allowed us to design and synthesize a target-directed dipeptidyl α,α-difluoromethyl ketone (DFMK) 8 as a potential antiviral agent with activity against human coronaviruses. The ability of the newly synthesized compound to inhibit viral replication was evaluated by a viral cytopathic effect…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture</strong> - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019. There is a critical global need for therapeutic intervention strategies that can be deployed to safely treat COVID-19 disease and reduce associated morbidity and mortality. Increasing evidence shows that both natural and synthetic antimicrobial peptides (AMPs), also…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Understanding Viral Infection Mechanisms and Patient Symptoms for the Development of COVID-19 Therapeutics</strong> - Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, has become a worldwide pandemic. Symptoms range from mild fever to cough, fatigue, severe pneumonia, acute respiratory distress syndrome (ARDS), and organ failure, with a mortality rate of 2.2%. However, there are no licensed drugs or definitive treatment strategies for patients with severe COVID-19. Only antiviral or anti-inflammatory drugs are used as symptomatic treatments based on clinician experience. Basic medical…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fluoxetine Can Inhibit SARS-CoV-2 In Vitro</strong> - An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the coronavirus disease pandemic, drastically affecting global health and economy. Though the understanding of the disease has improved, fighting the virus remains challenging. One of the strategies is repurposing existing drugs as inhibitors of SARS-CoV-2. Fluoxetine (FLX), a selective serotonin reuptake inhibitor, reportedly inhibits the replication of RNA viruses, especially Coxsackieviruses B (CVB), such…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro</strong> - The current COVID-19 pandemic requires urgent development of effective therapeutics. 5-amino levulinic acid (5-ALA) is a naturally synthesized amino acid and has been used for multiple purposes including as an anticancer therapy and as a dietary supplement due to its high bioavailability. In this study, we demonstrated that 5-ALA treatment potently inhibited infection of SARS-CoV-2, a causative agent of COVID-19, in cell culture. The antiviral effects could be detected in both human and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review</strong> - Leflunomide (LF) represents the prototype member of dihydroorotate dehydrogenase (DHODH) enzyme inhibitors. DHODH is a mitochondrial inner membrane enzyme responsible for catalytic conversion of dihydroorotate into orotate, a rate-limiting step in the de novo synthesis of the pyrimidine nucleotides. LF produces cellular depletion of pyrimidine nucleotides required for cell growth and proliferation. Based on the affected cells the outcome can be attainable as immunosuppression, antiproliferative,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring the efficacy of naturally occurring biflavone based antioxidants towards the inhibition of the SARS-CoV-2 spike glycoprotein mediated membrane fusion</strong> - Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism. Nefamostat, a FDA approved drug, well-known as a serine protease inhibitor for MERS-CoV infection, was used as the reference compound. Both the biflavones, showed potential as inhibitors for SARS-CoV-2 S protein-mediated…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae</strong> - Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Though NIC is already FDA-approved, administration of the currently available oral formulation results in systemic drug levels that are too low for the inhibition of SARS-CoV-2. We hypothesized that the co-formulation of NIC with an endogenous protein, human lysozyme (hLYS), could enable the direct aerosol delivery of the drug to the respiratory tract as an…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors</strong> - The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To understand the differences between antibody responses in mild versus severe cases of COVID-19, we analyzed the B cell responses in patients 1.5 months post SARS-CoV-2 infection. Severe, and not mild, infection correlated with high titers of IgG against Spike receptor binding domain (RBD) that were capable of ACE2:RBD inhibition. B cell receptor (BCR) sequencing…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clonal dispersion of Acinetobacter baumannii in an intensive care unit designed to patients COVID-19</strong> - CONCLUSIONS: Clonal spread of A. baumannii (AdeABCRS+) highlights the importance of adopting good practices for equipment disinfection, surfaces and management of COVID-19 patients.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19</strong> - Two proteases produced by the SARS-CoV-2 virus, the main protease and papain-like protease, are essential for viral replication and have become the focus of drug development programs for treatment of COVID-19. We screened a highly focused library of compounds containing covalent warheads designed to target cysteine proteases to identify new lead scaffolds for both M^(pro) and PL^(pro) proteases. These efforts identified a small number of hits for the M^(pro) protease and no viable hits for the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19</strong> - Obesity and obesogenic comorbidities have been associated with COVID-19 susceptibility and mortality. However, the mechanism of such correlations requires an in-depth understanding. Overnutrition/excess serum amino acid profile during obesity has been linked with inflammation and reprogramming of translational machinery through hyperactivation of amino acid sensor mammalian target of rapamycin (mTOR), which is exploited by SARS-CoV-2 for its replication. Conversely, we have shown that the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress</strong> - The brain endothelium is an integral element of the blood-brain barrier (BBB). Dysfunction of this formation due to increased generation of reactive oxygen species (ROS) progresses the establishment of neurological disorders including stroke and traumatic brain injury. Heat shock protein 90 inhibitors are anti-inflammatory agents, and their activities are mediated, at least in part, by P53. This is a tumor suppressor protein which regulates the opposing activities of Rac1 and RhoA in the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE(2)?</strong> - Inflammation is a protective response that develops against tissue injury and infection. Chronic inflammation, on the other hand, is the key player in the pathogenesis of many inflammatory disorders including cancer. The cytokine storm, an inflammatory response flaring out of control, is mostly responsible for the mortality in COVID-19 patients. Anti-inflammatory drugs inhibit cyclooxygenases (COX), which are involved in the biosynthesis of prostaglandins that promote inflammation. The…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 antibodies</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU315792577">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 antibodies</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU315792579">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A PHARMACEUTICAL COMPOSITION OF NITAZOXANIDE AND MEFLOQUINE AND METHOD THEREOF</strong> - A pharmaceutical composition for treating Covid-19 virus comprising a therapeutically effective amount of a nitazoxanide or its pharmaceutically acceptable salts thereof and an mefloquine or its pharmaceutically acceptable salts thereof is disclosed. The pharmaceutical composition comprises the nitazoxanide in the ratio of 0.05% to 66% w/v and the mefloquine in the ratio of 0.05% to 90% w/v. The composition is found to be effective for the treatment of COVID -19 (SARS-CoV2). The pharmaceutical composition of nitazoxanide and mefloquine has been found to be effective and is unexpectedly well tolerated with a low rate of side-effects, and equally high cure-rates than in comparable treatments. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN316412781">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TREATMENT OF COVID-19 WITH REBAMIPIDE</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU315792482">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD AND APPARATUS FOR ACQUIRING POWER CONSUMPTION IMPACT BASED ON IMPACT OF COVID-19 EPIDEMIC</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU314745621">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种新冠肺炎CT检测识别定位系统及计算设备</strong> - 本发明涉及图像处理领域，公开了一种新冠肺炎CT检测识别定位系统及计算设备，包括图像采集单元、模块建立单元、新冠肺炎病灶识别单元和新冠肺炎病灶定位单元；图像采集单元采集待识别检测新冠肺炎的CT图像、新冠肺炎CT影像病灶分割训练数据集和新冠CT图像识别训练集；模块建立单元建立U_Net卷积神经网络模型、加入注意力机制的InceptionV3网络和目标检测模型；新冠肺炎病灶识别单元对已分割出病灶的轮廓特征图像进行识别；新冠肺炎病灶定位单元确定病灶在人体肺部的位置。本发明利用U_Net卷积神经网络模型对新冠病灶检测分割，并通过加入注意力机制的网络进行新冠肺炎识别，通过目标检测模型定位病灶在肺部的位置，识别准确率高，计算速度快。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN317076812">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种基于磁微粒化学发光的新型冠状病毒抗体检测试剂盒</strong> - 本发明提供一种基于磁微粒化学发光的新型冠状病毒抗体检测试剂盒。所述检测试剂盒包括：链霉亲和素磁微粒、生物素标记的新型冠状病毒抗原、吖啶磺酰胺标记的二抗、样本稀释液和质控品；所述生物素标记的新型冠状病毒抗原包括重组核衣壳蛋白和重组棘突蛋白S1。将待检样本、生物素标记抗原与链霉亲和素磁微粒混合，孵育和洗涤，再加入吖啶磺酰胺标记的抗体，形成磁微粒‑链霉亲和素‑生物素‑抗原‑新型冠状病毒抗体‑二抗复合物，进而检测发光强度实现对待测样品的定性。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN317076655">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A PHARMACEUTICAL COMPOSITION OF ARTESUNATE AND MEFLOQUINE AND METHOD THEREOF</strong> - A pharmaceutical composition for treating Covid-19 virus comprising a therapeutically effective amount of an artesunate or its pharmaceutically acceptable salts thereof and a mefloquine or its pharmaceutically acceptable salts thereof is disclosed. The pharmaceutical composition comprises the artesunate in the ratio of 0.25% to 66% w/v and mefloquine in the ratio of 0.25% to 90% w/v. The composition is found to be effective for the treatment of COVID -19 (SARS-CoV2). The pharmaceutical composition of Artesunate and Mefloquine has been found to be effective and is unexpectedly well tolerated with a low rate of side-effects, and equally high cure-rates than in comparable treatments. The present invention also discloses a method to preparing the pharmaceutical composition comprising of Artesunate and Mefloquine. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN315303355">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Zahnbürstenaufsatz, elektrische Versorgungseinheit einer elektrischen Zahnbürste, elektrische Zahnbürste mit einem Zahnbürstenaufsatz, Zahnbürste sowie Testaufsatz für eine elektrische Zahnbürste</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE315274678">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种医用可佩戴式防护口鼻的微型气幕系统</strong> - 本发明公开了一种医用可佩戴式防护口鼻的微型气幕系统，包括框柱，框柱一侧开凿有气幕送风口和呼吸用送风口，气幕送风口和呼吸用送风口内分别连接有软管一和软管二，框柱内开凿有水平条缝和垂直条缝，水平条缝与垂直条缝均与气幕送风口相连通，框柱靠近水平条缝的一侧贯穿开凿有出风口，出风口内设有滤网，出风口贯穿框柱的一端连接有高效过滤器，滤网与高效过滤器之间连接有吸气泵，框柱靠近出风口的一侧连接有电池和开关。本发明通过提出一种在口腔处应用洁净空气幕阻挡气溶胶传播的可佩戴装置，可以在口腔类相关诊疗过程，保护医生和周围人的健康，避免引起可能引发的呼吸道疾病交叉感染。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN316342421">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Biden White House Is Tossing Obama’s Economics Playbook</strong> - Joe Biden and Janet Yellen are proving to be far bolder than past Democratic Administrations. - <a href="https://www.newyorker.com/news/our-columnists/the-biden-white-house-is-tossing-obamas-economics-playbook">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can Biden Reverse Trump’s Damage to Latin America?</strong> - The new President has vowed to end his predecessor’s “incompetence and neglect” in the region, but first he must convince allies to trust Washington again. - <a href="https://www.newyorker.com/news/news-desk/can-biden-reverse-trumps-lasting-damage-in-latin-america">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump’s Impeachment-Trial Lawyers Refuse to Seriously Engage with the Constitutional Issues</strong> - What looks like incompetence by Bruce Castor and David Schoen may be better understood as contempt for the process. - <a href="https://www.newyorker.com/news/daily-comment/trumps-impeachment-trial-lawyers-refuse-to-seriously-engage-with-the-constitutional-issues">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“We Lost the Line”: Trump Is on the Brink of Yet Another Senate Acquittal</strong> - Republican senators ran for their lives, but they will not run from the former President. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/we-lost-the-line-trump-is-on-the-brink-of-yet-another-senate-acquittal">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What the Impeachment Trial Tells Us About the Biden Administration</strong> - There is something a bit illusory about the impeachment trial, in that its central dramas are all about Republicans, and the real action in Washington is about the Democrats. - <a href="https://www.newyorker.com/news/our-columnists/the-surprising-progressivism-of-the-biden-administration">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>One Good Thing: The pulpy joys of the Bruce Lee-inspired Warrior</strong> -
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/zS9joSjyh50IbDyYvcuYKdiQOaI=/238x196:1683x1280/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68808607/chen_tang_jason_tobin_andrew_koji.0.jpg"/>
<figcaption>
<em>Warrior</em> follows the Hop Wei, a powerful tong that deals opium, in their power struggles during the San Francisco Tong Wars of the 1980s. | Graham Bartholomew/Cinemax
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Warrior feels like if Peaky Blinders starred Bruce Lee and was set in 1870s Chinatown. It’s great.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zmZTAJ">
Before he died tragically in 1973 at the age of 32, Bruce Lee was writing the beginnings of a martial arts Western television series. It was a chance for the Chinese American actor, who had long played supporting characters in American films, to finally star as the hero of his own show. Lee pitched it to the studios, but <a href="https://www.theringer.com/tv/2019/4/9/18301042/warrior-bruce-lee-stunt-coordinator-interview">according to him</a>, producers didn’t think audiences were ready for a show with a nonwhite lead. He died before he could see his vision through.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AaI6PR">
Years later, Lee’s daughter, actress and martial artist Shannon, <a href="https://ew.com/tv/2019/04/08/bruce-lee-daughter-shannon-lee-warrior/">discovered</a> an eight-page treatment for the show in her father’s journals after taking over the Bruce Lee Foundation, an organization dedicated to his legacy, in 2000. She picked up where her father left off, <a href="https://deadline.com/2019/06/shannon-lee-bruce-lee-warrior-interview-cinemax-1202622774/">collaborating with Justin Lin</a>, director of the <em>Fast &amp; Furious </em>franchise. The resulting <em>Warrior</em> feels like the series Lee <a href="https://deadline.com/2019/06/shannon-lee-bruce-lee-warrior-interview-cinemax-1202622774/">would have wanted</a>: pulpy, action-filled genre television that centers Chinese American stories.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NYDaC5">
<em>Warrior </em>premiered on Cinemax in 2019 and aired for two 10-episode seasons, both of which are available to stream on HBO Max. There’s a lot about the show that will be recognizable to fans of today’s dark antihero dramas: The gangster storyline feels like a plot from <em>Boardwalk Empire</em> or <em>Peaky Blinders</em>, the frontier fable of capitalism resembles <em>Deadwood</em>, and warring factions vying for power recall similar conflicts on <em>Game of Thrones</em>. But what sets <em>Warrior</em> apart is its focus on a fascinating chapter in the American story that’s often treated like an afterthought in history books. And it wraps that history lesson in an enticing action-thriller package with nods to spaghetti Westerns, the kung fu cinema of Hong Kong, gangster flicks, and exploitation films, as well as other grindhouse genres.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GGuSfv">
<em>Warrior</em> takes place in 1870s San Francisco — the city where Bruce Lee was born — during a wave of Chinese migration, primarily to provide labor for America’s new railroads. Newly arrived Chinese immigrants, facing discrimination and sequestered in Chinatowns in major cities across the country, self-organized into gangs, or “tongs,” as a way to survive. The violent <a href="https://www.sfchronicle.com/chronicle_vault/article/When-SF-police-broke-the-law-to-combat-14904377.php">Tong Wars</a> ensued as anti-Chinese sentiment swept the nation, ultimately leading to the 1882 passage of the shameful Chinese Exclusion Act, the sole piece of legislation in American history that banned the immigration of an entire nationality.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="prHW7i">
<em>Warrior</em>’s story follows Ah Sahm (Andrew Koji), a poor Chinese immigrant with first-class fighting skills who arrives on the shores of America in search of his sister, Mai Ling (Diane Doan). Once he arrives, he’s immediately initiated into the Hop Wei, a tong that sells opium in San Francisco’s Chinatown. Soon he discovers that Mai Ling, who had come to America years earlier, is now married to the powerful leader of an opposing tong. Their reunion ignites long-simmering tensions between the tongs, triggering a power play between the long-lost siblings over who will take over Chinatown.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/b9mBMuhiLkmN9d9ja5TbWiVb-84=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22298466/war_101_110217_gb_3079_12477.jpg"/> <cite>David Bloomer/Cinemax</cite>
<figcaption>
Andrew Koji plays Ah Sahm, a skilled martial artist and member of the Hop Wei tong.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0J7Ut6">
The show’s universe is hard-boiled, steeped in menacing violence and the cutthroat core of American capitalism. The tongs operate on enforced loyalty under threat of death, but you can’t help but admire them for staking out a small piece of power in a country where Chinese people are villainized and shut out of society. The alternative is to work as a cheap laborer subjected to backbreaking conditions for starvation wages. Meanwhile, the city’s Irish workers, who have found their jobs undercut by the new migrants, routinely attack both the Chinese and the factories where they work.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tjYvcV">
<em>Warrior</em>’s characters are survivors. Ah Toy (Olivia Cheng), the bisexual madam of a Chinatown brothel, is trying to not only build a safety net for herself but also provide a better alternative to more exploitative avenues of sex work — or, in the direst circumstances, sex slavery — for Chinese women. Weapons dealer Chao (Hoon Lee) makes his way and tries to get ahead by selling hatchets and information to the highest bidder, including the police. For me, the standout character is Baby Jun, the bastard son of a tong leader and sex worker, who is played with humor and recklessness by Jason Tobin.
</p>
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<img alt=" " src="https://cdn.vox-cdn.com/thumbor/JYPe3mxkoQcHPJrKpgzE4kiVE_Q=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22298497/war_101_110117_gb_2992_12476.jpg"/> <cite>David Bloomer/Cinemax</cite>
<figcaption>
Olivia Cheng plays the madam Ah Toy, based on a real-life frontier sex worker.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7derM5">
<em>Warrior </em>focuses on its Chinese American characters, who are just trying to make it in this country. But the show’s villains are compelling figures too. Dean Jagger’s Dylan Leary is particularly interesting as a union leader who mixes genuine concern for his fellow working-class Irish immigrants with the terrifying and violent rage of a racist. The show’s police, mostly Irish themselves, are depicted as unbridled enforcers of wealth and white supremacy, but a Southern cop named Officer Lee (Tom Weston-Jones) makes an admirable attempt to do actual police work. To the industrialists, the Chinese matter little beyond providing a cheap labor source, but it’s hard not to root for Penny (Joanna Vanderham), a woman whose inherited steel factory is her only route to independence from her horrific husband, the mayor.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9okM2y">
The immigrant caste system of the show is one of its strongest storytelling features. Recently migrated Chinese are at the bottom, Irish migrant laborers and police officers the next rung up, yet all sit underneath the white Anglo-Saxon Protestant (WASP) industrialists and politicians — who are, of course, on stolen land themselves. The question of who gets to truly be American and how that question is used to exploit the working class is a core theme of <em>Warrior</em> that feels especially relevant to today’s politics.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TrFn5D">
And the real-world stories and figures that inspire <em>Warrior’</em>s storytelling — Ah Toy is based on a <a href="https://www.nybooks.com/daily/2020/06/19/ah-toy-pioneering-prostitute-of-gold-rush-california/">real gold rush-era madam</a>, and Dylan Leary is based on the labor organizer and founder of the Workingmen’s Party, <a href="https://www.denofgeek.com/tv/warrior-the-historical-inspiration-for-dylan-leary/">Denis Kearney</a> — are refreshing. As a huge fan of period television, I’ve long wanted to see more people who look like me at the center of these shows. This is part of what felt so intriguing about the recent debut of Netflix’s popular <a href="https://www.vox.com/22178125/bridgerton-netflix-review-regency-romance"><em>Bridgerton</em></a>, which transplants characters of color into a Jane Austen-style romance. But representation can feel like a shallow concession when portrayed without consequence, subbing out would-be white characters for nonwhites with little more than an obligatory nod to the realities of racial dynamics. That’s why I’ve found <em>Warrior </em>so satisfying to watch: Here is a little-known piece of actual Chinese American history, rooted in America’s history of immigrant exploitation, playing out on screen.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/sSJZXrpDv_4yp4jsxrLxmO11Huo=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22298519/war_103_021518_db_1752_12479.jpg"/> <cite>David Bloomer/Cinemax</cite>
<figcaption>
The character of Dylan Leary (played by Dean Jagger) is based on a real labor organizer and anti-Chinese agitator.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2YeJ8U">
The fact that <em>Warrior</em> is imbued with the legacy of Bruce Lee, an icon of Asian American cinema, just adds to the show’s Asian American specificity. The influence of Justin Lin, action-movie mogul and one of the most powerful Asian American creatives in Hollywood, is most obvious in the series’ terrific fight sequences. However, I was reminded more of Lin’s underrated first film <em>Better Luck Tomorrow</em>, which also depicted Asian-Americans — freed from the stereotype of silent obedience — breaking bad.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0zXfNz">
But I don’t mean to make the show sound preachy or pedantic. I promise, <em>Warrior</em> is just really fun to watch. Its martial arts sequences are standouts, as complex as they are bloody, and the dialogue feels straight out of a dark graphic novel. Because the show originated on Cinemax, there’s a lot of sex and violence, as well as racial slurs that at times slip into “gratuitous” territory. But because <em>Warrior</em> feels like a deliberate tribute to grindhouse movies, it all sort of fits.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RKi6EK">
Sadly, the untimely <a href="https://www.wsj.com/articles/how-the-launch-of-hbo-max-sidelined-cinemax-11592839882">demise of Cinemax</a> in 2020 means that <em>Warrior</em> is effectively canceled. Now that it’s streaming on HBO Max, however, there is a glimmer of possibility the show will find a wider audience and maybe get picked up for another season as an HBO Max original. I hope it does. I’d love to see the universe of <em>Warrior</em> expand, especially to include other groups in late 1800s California; an episode that focuses on a Mexican American street-fighting host and the introduction of the show’s first Black character are signs the show, at one time or another, intended to do just that.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qReg3U">
But regardless of whether the show is ever revived, <em>Warrior</em>’s two completed seasons provide a satisfying storyline. The penultimate episode of season two, a violent clash in Chinatown following the lynching of a Chinese man — based on the real-world <a href="https://www.denofgeek.com/tv/warrior-the-real-history-of-the-race-riot-that-shook-san-francisco/">San Francisco Riot of 1877</a> — feels like a culmination of the series, despite the cliffhanger that follows in the next episode.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TWYelI">
Ultimately, the episode that best encapsulates <em>Warrior</em> for me is a season one installment in which a spaghetti-Western-style shootout erupts in a saloon in Grass Valley, Nevada. The small business is owned and operated by a former Chinese railroad laborer who toiled for decades before using his long-saved earnings to build a homestead in the middle of nowhere with his American wife. Their life feels like the realization of a humble immigrant fantasy that, suddenly sieged by violence, is as precarious as it is rare. As Baby Jun, one of the show’s few second-generation Chinese migrants, says in the episode, “I’m sure no fucking American. I don’t belong anywhere.” <em>Warrior</em> is about the many Americans who have not (and probably will never) really belong, but who have no choice but to keep grinding for the chance at a small piece of the American dream.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VpIph0">
Warrior<em> is streaming on HBO Max. For more recommendations from the world of culture, check out the </em><a href="https://www.vox.com/one-good-thing">One Good Thing</a><em> archives.</em>
</p></li>
<li><strong>To All the Boys: Always and Forever suffers from a case of diminishing returns</strong> -
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/nsQk1G39gp06jhW21s1vPzobZM8=/267x0:4534x3200/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68807874/TATB3_Unit_10099_R.0.jpg"/>
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Lana Condor as Lara Jean Covey in <em>To All the Boys: Always and Forever</em>. | Katie Yu/Netflix
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The first To All the Boys film was an instant classic. What happened?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mPP2E0">
As the closing credits scroll on <a href="https://www.imdb.com/title/tt10676012/?ref_=ttfc_fc_tt"><em>To All the Boys: Always and Forever</em></a>, the third and final volume in Netflix’s sweet teen love trilogy, clips from all three films play in the background. And as they played, I found myself desperately trying to work out what it was that made the first entry in the trilogy — 2018’s <a href="https://www.vox.com/culture/2018/8/19/17756330/to-all-the-boys-ive-loved-before-review-netflix"><em>To All the Boys I’ve Loved Before</em></a>, directed by Susan Johnson — so much more compelling than the other two. Even in soundless 10-second clips, it was so much better than its successors that it hurt a little.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fJUA5M">
Maybe it’s the weight of the hype. When the first <em>To All the Boys</em> movie came out in 2018, it was an unexpected success, a dark horse that became one of the most-watched and re-watched original movies on Netflix and single-handedly made teen icons out of both Lana Condor and Noah Centineo. It could afford to be low-stakes and surprising because few critics were expecting much from it. But the next two movies had high expectations to live up to.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eV3JGB">
Was it the lighting? All three <em>To All the Boys</em> movies are rendered in joyous shades of turquoise and sunshine yellow and pink, like a platter of vividly toned macarons. But there was a slight bleaching to certain scenes in that first movie, an occasional willingness to let the light be ugly or distorting when it felt right, so that when it went sun-drenched and romantic, the romance really landed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CMBro4">
That willingness has completely vanished from the other two movies — and with it has gone any sense that these films might ever be willing to get really sad, or that their characters might ever experience anything other than temporary distress. Which means the happiness that they do inevitably encounter becomes a little bit cheap.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hBS0E1">
Or maybe it was the costumes?
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ReRaZr">
In the first film, our heroine Lara Jean (Lana Condor) was dressed by Rafaella Rabinovich <a href="https://www.vox.com/culture/2018/8/27/17778022/to-all-the-boys-ive-loved-before-netflix-fashion-rafaella-rabinovich">in clothes that mixed references freely from the ’60s to the ’90s</a>. Then, Lara Jean displayed a tendency to mix sweet and girly frills with a little punk drama: she was always wearing combat boots with her pink miniskirts, or pairing her bows with a sharp-edged neon plaid. But in 2020’s <a href="https://www.vox.com/culture/2020/2/10/21113584/to-all-the-boys-ps-i-still-love-you-review-netflix"><em>To All the Boys: P.S. I Still Love You</em></a>, and in the latest outing, <em>Always and Forever</em> (both directed by Michael Fimognari), Lara Jean is dressed by Lorraine Carson in a softly romantic mod wardrobe without a trace of punk to it. She wears her sunshine-yellow frocks with flat teal sandals, and all her plaids are sweet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PwBe9M">
Lara Jean looks great in all three films. But the girly girl/cool chick combo of the first movie didn’t just look great. It also doubled as character development. It suggested that nice girl Lara Jean had a few hidden sharp edges herself, and that there was some secret badass potential inside of her that, if given the right encouragement, might finally emerge.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2baC9P">
With the wardrobe of the second and third films, that layer of character work is gone. There’s no longer any suggestion of secret badassery in the way Lara Jean is presented to us. There’s just flat and straightforward sweetness.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W8IqIj">
In that same way, the light in the second and third films is straightforwardly sweet, without melancholy. And the story is straightforwardly sweet, without real potential for tragedy. It all feels sweet right up to the edge of becoming cloying, and maybe even stepping over the threshold.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ow7qMC">
Whatever it is, some fundamental alchemy has leached out of this trilogy. Some under-the-radar willingness to get weird and sad — a willingness that made the straightforward trope-driven structure of that first movie’s happy ending feel earned and lovely and lived-in — has disappeared.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="95wxKe">
<em>To All the Boys: Always and Forever</em> is a perfectly fine, competent, and forgettable teen romance. It’s a better movie than 2020’s <em>P.S. I Still Love You</em>, largely because its central conflict is stronger than that film’s DOA love triangle. But it doesn’t come anywhere close to the heights of the original <em>To All the Boys</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WDkvKg">
This movie is just okay. It’s nothing more than that.
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<h3 id="GMo06y">
<em>Always and Forever</em> deals with that great nemesis of high school love: college
</h3>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="06jWE5">
<em>Always and Forever</em> finds high school sweethearts Lara Jean Covey and Peter Kavinsky (Centineo) entering spring of their senior year. After fake dating in the first movie, and surviving a romantic rival for Lara Jean’s affections in the second, they’re now preparing to face their biggest trial of all: college.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kxFhcf">
Peter plans to go to Stanford (lol, sure), where he’s landed a lacrosse scholarship (<a href="https://www.ruleoftree.com/2016/7/31/12329878/stanford-football-faces-extraordinary-recruiting-challenges">lololol, sure</a>). Lara Jean is certain she’ll be admitted as well — but when she’s rejected, she has a backup plan. She is willing to settle for UC Berkeley, where she did get in, and which is just an hour’s drive away from Stanford. And surely, Peter tells her, she can transfer to Stanford as long as she keeps her grades up. So really, they’ll only be separated for one year, not four. (It’s worth noting that in the books by Jenny Han on which the <em>To All the Boys</em> films are based, this plotline involves the University of Virginia. Han’s version, it must be said, makes a lot more sense than Peter and Lara Jean betting their relationship on both of them getting into <a href="https://www.usnews.com/best-colleges/stanford-university-1305">a school with an acceptance rate of 4 percent</a>.)
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V60MVf">
But Lara Jean has also been accepted to NYU. And on a class trip to New York, she finds herself falling in love with the city. She starts to think that maybe she might actually want to go to NYU, thousands of miles away from Stanford — and maybe she might want to go for all four years, not just for one year until she can transfer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MZMBMa">
Peter, who is working through some abandonment issues left over from growing up with an absent father, does not take this idea well. “We both know what 3,000 miles of distance will do to us,” he tells her.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6Kl20d">
On a purely structural level, the question of how college will affect our lovers’ relationship is a much richer and more interesting problem for them to face than the second movie’s question of whether Lara Jean was going to choose some other, non-Peter guy (she didn’t). It’s a meaningful and relatable problem that real-life high school couples face every year. It has a pleasing symmetry with the first <em>To All the Boys</em> film, which began when Lara Jean’s older sister dumped her high school boyfriend as she prepared to go off to college. And it comes with layers of conflict for Centineo and Condor to play through, with their smiles growing a little bit tenser in each successive scene as one obstacle after another seems to land between Lara Jean and Peter.
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<h3 id="32giMA">
Condor and Centineo continue to have appealing chemistry. That’s not enough.
</h3>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/DuiIQmrvh6gOFBpnMPDyNAUrMuk=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22297743/TATB3_Unit_10957_R.jpg"/> <cite>Katie Yu/Netflix</cite>
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Noah Centineo and Lana Condor as Peter and Lara Jean in <em>To All the Boys: Always and Forever</em>.
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</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vz6xQ0">
Centineo and Condor remain the best part of <em>To All the Boys: Always and Forever</em>, as they were the best part of <em>P.S. I Still Love You</em>. They have a wholesomely sexy chemistry that manages to keep even their cutest moments from ever quite descending into cutesiness, and they can sell the giddy joy of first love as easily as they sell their terror at their looming separation. Centineo remains the reigning champion of the longing gaze, and while Condor’s gift for comic timing goes underused in <em>Always and Forever</em>, every time she has the chance to break it out, she reminds us just how funny and endearing she can be.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="C5sROD">
But like <em>P.S. I Still Love You</em>, <em>Always and Forever</em> fails to find strong, specific details in which to ground this love story. Gone are the yogurt smoothies, the hands in back pockets, the stolen scrunchies. Instead, <em>Always and Forever</em> is heavy on the wordless montages, where you don’t need interesting details because you can just rely on a romantic setting and your actors’ smiles to do the work for you. And the film leans on lazy and underwritten references to <em>Pride and Prejudice</em> and <em>Romeo and Juliet</em>, neither of which particularly applies to the story we’re watching play out between Peter and Lara Jean.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b4TNaA">
It all feels a little bit generic, a little bit lazy, a little bit too sweet. None of it is executed with the flair this trilogy demonstrated it was capable of showing in its first outing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1tFz8n">
So as this sweet-natured high school romance comes to a close, it’s not getting the happy ending it deserves. Instead, the <em>To All the Boys</em> series fades out on what feels all too much like a case of diminishing returns.
</p></li>
<li><strong>“Who’s to say it won’t happen again?”: Democrats warn of the risks of acquittal</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/iP6MvVqIUeEBUe762sIy8Azfh80=/547x0:5411x3648/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68806704/1301624439.0.jpg"/>
<figcaption>
Sen. Lisa Murkowski (R-AK) arrives at the US Capitol on the third day of former President Donald Trump’s impeachment trial on February 11. | Chip Somodevilla/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Moderate Republicans are betting Trump has no political future. Democrats argue that’s the problem.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ikf6Qd">
Closing their second day of arguments in former President Donald Trump’s impeachment trial, House Democrats warned of the real danger of acquittal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3OUVOY">
Asking senators to weigh the threat of letting Trump’s incitement of an insurrection go unpunished, House impeachment managers detailed his history of stoking violence and the ongoing threat of domestic terrorism that his actions have encouraged. Their intent: making it clear that January 6 was an extension of a pattern — rather than an aberration — and could be repeated if consequences are not imposed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GyHqXO">
“Senators, the evidence is clear,” Rep. Joe Neguse (D-CO) said in his closing statement. “We showed you statements, videos, affidavits that prove President Trump incited an insurrection — an insurrection that he alone had the power to stop.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eLc0vQ">
“We humbly, humbly ask you to convict President Trump for the crime for which he is overwhelmingly guilty,” Neguse continued. “Because if you don’t, if we pretend this didn’t happen — worse, if we let it go unanswered — who’s to say it won’t happen again?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bKW0NF">
Some Republicans, including <a href="https://www.npr.org/sections/trump-impeachment-trial-live-updates/2021/02/11/966984248/he-can-do-this-again-rep-lieu-warns-of-future-attacks-on-democracy">Trump’s defense lawyer Bruce Castor</a> and <a href="https://www.newsweek.com/senator-kevin-cramer-playfully-asks-why-democrats-are-concerned-about-2024-trump-campaign-1568383">Sen. Kevin Cramer (R-ND)</a>, have suggested Democrats are only pursuing impeachment because they are worried about Trump running for president in 2024 and winning, as he did in 2016.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="anxVhx">
But Democrats responded directly to that line of thinking,<strong> </strong>arguing another Trump loss, rather than a victory, would be riskier for American democracy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tWjV8a">
“President Trump’s lack of remorse shows that he will undoubtedly cause future harm if allowed, because he still refuses to account for his previous high, grave crime against our government,” Rep. Ted Lieu (D-CA) said. “I’m not afraid of Donald Trump running again in four years. I’m afraid he’s going to run again and lose — because he can do this again.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S2lCA1">
The question of what Trump will do next is not just a Democratic concern. It’s splitting the GOP. Senate Minority Leader <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fwww.newyorker.com%2Fmagazine%2F2021%2F02%2F01%2Fwhy-mcconnell-dumped-trump&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2F2021%2F2%2F11%2F22279010%2Fmurkowski-mcconell-lieu-impeachment-acquittal-risk" rel="sponsored nofollow noopener" target="_blank">Mitch McConnell formally broke from Trump after the insurrection</a>, laying the blame directly at Trump’s feet for promoting election conspiracies. McConnell <a href="https://nymag.com/intelligencer/article/mcconnell-not-plotting-save-republicans-trump.html">will not whip the impeachment vote</a>, and his own vote is reportedly undecided, though he voted with the majority of his caucus that the trial was unconstitutional.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ovSty1">
Some Republican lawmakers continue to repeat the former president’s ongoing assertions of election fraud. Those unsubstantiated claims play well with parts of<strong> </strong><a href="https://www.cnn.com/2021/02/04/politics/2020-election-donald-trump-voter-fraud/index.html">the electorate</a> and are becoming a mandate for state-level Republican attempts to enact <a href="https://www.vox.com/22254482/republicans-voter-suppression-state-legislatures">their largest voter suppression campaign in years</a> — both of which could help keep these senators in office.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qZ55Yt">
Others in the Senate GOP are betting, as Democrats outlined, that he will run again and lose. The difference is that, despite the two days of evidence Democrats presented, they do not seem to share the same fears that he could incite violence yet again, or are too afraid of offending the former president’s base to say so.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="64SFmC">
On Tuesday, Sen. Lisa Murkowski (R-AK), one of the caucus’s more moderate members and one of six Republicans to vote that the trial was constitutional, said the evidence was damning. But she came to a conclusion that House Democrats are arguing misses the real danger.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mU1v7b">
“After the American public sees the full story laid out here … I don’t see how Donald Trump could be reelected to the president again,” <a href="https://thehill.com/homenews/senate/538334-murkowski-i-dont-know-how-trump-could-be-elected-again">she told reporters, according to the Hill</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6zWdXY">
Democrats argue the risk lies in his continued false claims about election fraud and are asking senators to use their power to ensure he cannot run again rather than just hoping his continued political viability does not lead to another, potentially more deadly, episode of political violence.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="irX2IB">
“My dear colleagues, is there any political leader in this room who believes if he’s ever allowed by the Senate to get back into the Oval Office, Donald Trump would stop inciting violence to get his way?” Raskin said. “Would you bet the lives of more police officers on that? Would you bet the safety of your family on that? Would you bet the future of your democracy on that? President Trump declared his conduct totally appropriate. So if he gets back into office and it happens again, we’ll have no one to blame but ourselves.”
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Opting out of IPL auction was a very difficult decision, says Joe Root</strong> - England know that two more wins in their remaining three Tests in India will see them qualify for the WTC final against New Zealand.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ind vs Eng | Pitch looks completely different and I am sure it will turn from day 1, says Rahane</strong> - Despite hinting that left-arm spin bowling all-rounder Axar Patel is available for selection, Rahane didn’t divulge the playing XI.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Debate around Kohli’s Test captaincy unneeded distraction but impossible to avoid, says Pietersen</strong> - Kevin Pietersen threw his weight behind Virat Kohli, saying he is perfectly capable to lead his side to victory.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India vs England | England make four changes to their 12-man squad for second Test</strong> - England lead the four match series 1-0 after defeating India by a massive 227 runs in the first Test.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australian Open | Osaka shows gentle touch to reach last 16</strong> - The third seed, champion in Melbourne two years ago, gently carried a butterfly to safety at the side of the court before closing out an easy 6-3, 6-2 victory over Tunisian 27th seed Ons Jabeur.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>J&amp;K govt. resolves row over hosting Khelo India games</strong> - Withdraws order for hoteliers to cancel tourist bookings for athletes, officials</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Five unions to boycott BPCL project launch by Modi</strong> - ‘He is inaugurating a project while going ahead with BPCL disinvestment’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Action against ‘Mizo aggression’ needed, Assam Congress says on border row</strong> - Decades-old boundary dispute between the two northeastern States flared up again on January 9</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Artists, comics call for withdrawal of charges against Munawar Faruqui</strong> - The arrest of Mr. Faruqui “even before he cracked a joke” was astounding and outrageous.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rangayana to stage two plays</strong> - Shivamogga Rangayana has invited theatre lovers for two plays this weekend. ‘Tahataha’, a production by Natyalekha Rangasamuha of Mysuru, will be stag</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia warns EU it could cut ties over sanctions</strong> - The EU is considering more sanctions on Russia over the case of Putin critic Alexei Navalny.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: Germany to halt travel from Czech Republic and Tyrol</strong> - Germany announces new border restrictions, while Austrian and Czech governments also restrict travel.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fernando Alonso: Two-time Formula 1 champion involved in road accident while cycling</strong> - Two-time champion Fernando Alonso has been involved in a road accident while cycling in Switzerland.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘Putin’s palace’: Builders’ story of luxury, mould and fake walls</strong> - The Black Sea mansion highlighted by Alexei Navalny is beset with construction issues, say builders.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UK economy suffered record annual slump in 2020</strong> - The size of the economy shrank by 9.9% in 2020 as coronavirus restrictions hit output, figures show.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rocket Report: Iran debuts new booster, SpaceX to launch Lunar Gateway</strong> - “Customer demand has been extremely strong.” - <a href="https://arstechnica.com/?p=1741615">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What happens when you replace a human gene with its Neanderthal version?</strong> - Neural stem cells with the Neanderthal version of a key gene behave differently. - <a href="https://arstechnica.com/?p=1741700">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple TV+ acquires a “sci-fi courtroom drama” about a murderous robot doll</strong> - Sci-fi is looking like a cornerstone of Apple TV+’s slowly growing library. - <a href="https://arstechnica.com/?p=1741475">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Caged heat: Mesquite bugs battle in a plastic cup—for science!</strong> - Two mesquite bugs enter, one mesquite bug leaves. - <a href="https://arstechnica.com/?p=1740335">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cox cuts some users’ uploads from 30Mbps to 10Mbps—here’s how to avoid it</strong> - Cox notifies users of speed cut, fails to mention they can keep current plan. - <a href="https://arstechnica.com/?p=1741592">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Wife: We just ate, why are you making pancakes?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Me: They’re for the dogs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Wife: Why are you making pancakes for the dogs?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Me: They don’t know how.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/RayInRed"> /u/RayInRed </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/li1zsl/wife_we_just_ate_why_are_you_making_pancakes/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/li1zsl/wife_we_just_ate_why_are_you_making_pancakes/">[comments]</a></span></p></li>
<li><strong>The Hospital</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A sweet old lady telephoned the hospital.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She timidly asked, “Is it possible to speak to someone who can tell me how a patient is doing?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The operator said, “I can, what’s the name and room number?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The old laday in her weak voice said, “Doreen Jacobs, Room 604.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The operator replied, “Let me place you on hold while I check with her nurse.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After a few minutes the operator returned to the phone and said, “Oh, I have good news, her nurse just told me that Doreen is doing very well. Her blood pressure is fine; her blood work just came back as normal and her physician, Dr. Ross, has scheduled her to be discharged on Tuesday.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The old lady said, “Thank you. That’s wonderful! I was so worried! God bless you!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The operator replied, “You’re more than welcome. Is Doreen your daughter?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The grandmother said, “No, I’m Doreen Jacobs in room 604. No one tells me shit.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/ES_FTrader"> /u/ES_FTrader </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lhyyqt/the_hospital/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lhyyqt/the_hospital/">[comments]</a></span></p></li>
<li><strong>Today I learned that if you’re in a canoe and it flips over in the water….</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
…..you can safely wear it on your head….because it’s capsized.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/VERBERD"> /u/VERBERD </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lhl1p8/today_i_learned_that_if_youre_in_a_canoe_and_it/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lhl1p8/today_i_learned_that_if_youre_in_a_canoe_and_it/">[comments]</a></span></p></li>
<li><strong>A male patient is lying in bed in the hospital, wearing an oxygen mask over his mouth and nose.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A pretty, young, student nurse appears to give him a partial sponge bath.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
‘Nurse’, he mumbles, from behind the mask. ‘Are my testicles black?’
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Embarrassed, the young nurse replies, ‘I don’t know, Sir. I’m only here to wash your upper body and feet.’
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He struggles to ask again, ‘Nurse, please check. Are my testicles black?’
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Concerned that he may elevate his blood pressure and heart rate from worry about his testicles, she overcomes her embarrassment and pulls back the covers. She raises his gown, holds his manhood in one hand and his testicles in the other.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Then, she takes a close look and says, ‘There’s nothing wrong with them, Sir!’
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man pulls off his oxygen mask, smiles at her and says very slowly: ’Thank you very much. That was wonderful, but, listen very, very closely…… ’Are my test results back?"
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/armyfidds"> /u/armyfidds </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lhov4g/a_male_patient_is_lying_in_bed_in_the_hospital/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lhov4g/a_male_patient_is_lying_in_bed_in_the_hospital/">[comments]</a></span></p></li>
<li><strong>I went to a restaurant and they asked me “Do you mind waiting a bit?”</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Not at all”, I replied.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Good”, they said, while handing me some menus. “Take these to Table 11.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/PR0CR45T184T0R"> /u/PR0CR45T184T0R </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/li0c4z/i_went_to_a_restaurant_and_they_asked_me_do_you/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/li0c4z/i_went_to_a_restaurant_and_they_asked_me_do_you/">[comments]</a></span></p></li>
</ul>
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