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<title>01 July, 2023</title>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication</strong> -
<div>
G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. G3BP1/2 are prominent interactors of the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the functional consequences of the G3BP1-N interaction in the context of viral infection remain unclear. Here we used structural and biochemical analyses to define the residues required for G3BP1-N interaction, followed by structure-guided mutagenesis of G3BP1 and N to selectively and reciprocally disrupt their interaction. We found that mutation of F17 within the N protein led to selective loss of interaction with G3BP1 and consequent failure of the N protein to disrupt stress granule assembly. Introduction of SARS-CoV-2 bearing an F17A mutation resulted in a significant decrease in viral replication and pathogenesis in vivo, indicating that the G3BP1-N interaction promotes infection by suppressing the ability of G3BP1 to form stress granules.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.06.29.546885v1" target="_blank">Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication</a>
</div></li>
<li><strong>In vivo characterization of the optical and hemodynamic properties of the human sternocleidomastoid muscle through ultrasound-guided hybrid near-infrared spectroscopies.</strong> -
<div>
The non-invasive monitoring of the hemodynamics and metabolism of the sternocleidomastoid muscle (SCM) during respiration became a topic of increased interest partially due to the increased use of mechanical ventilation during the COVID-19 pandemic. Near-infrared diffuse optical spectroscopies were proposed as potential practical monitors of increased recruitment of SCM during respiratory distress. They can provide clinically relevant information on the degree of the patient's respiratory effort that is needed to maintain an optimal minute ventilation, with potential clinical application ranging from evaluating chronic pulmonary diseases to more acute settings, such as acute respiratory failure, or to determine the readiness to wean from invasive mechanical ventilation. In this paper, we present a detailed characterization of the optical properties (wavelength dependent absorption and reduced scattering coefficients) and hemodynamic properties (oxy-, deoxy- and total hemoglobin concentrations, blood flow, blood oxygen saturation and metabolic rate of oxygen extraction) of the human SCM, obtained by measuring sixty-five subjects through ultrasound-guided near-infrared time-resolved and diffuse correlation spectroscopies. We provide detailed tables of the results related to SCM baseline (i.e. muscle at rest) properties, and reveal significant differences on the measured parameters due to variables such as side of the neck, sex, age, body mass index and thickness of the overlaying tissues, allowing future clinical studies to take into account such dependencies.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.06.30.544760v1" target="_blank">In vivo characterization of the optical and hemodynamic properties of the human sternocleidomastoid muscle through ultrasound-guided hybrid near-infrared spectroscopies.</a>
</div></li>
<li><strong>Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform</strong> -
<div>
Drug repurposing is an important strategy in COVID-19 treatment, but many clinically approved compounds have not been extensively studied in the context of embryogenesis, thus limiting their administration during pregnancy. Here we used the zebrafish embryo model organism to test the effects of 162 marketed drugs on cardiovascular development. Among the compounds used in the clinic for COVD-19 treatment, we found that Remdesivir led to reduced body size and heart functionality at clinically relevant doses. Ritonavir and Baricitinib showed reduced heart functionality and Molnupiravir and Baricitinib showed effects on embryo activity. Sabizabulin was highly toxic at concentrations only 5 times higher than Cmax and led to a mean mortality of 20% at Cmax. Furthermore, we tested if zebrafish could be used as a model to study inflammatory response in response to spike protein treatment and found that Remdesivir, Ritonavir, Molnupiravir, Baricitinib as well as Sabizabulin counteracted the inflammatory response related gene expression upon SARS-CoV-2 spike protein treatment. Our results show that the zebrafish allows to study immune-modulating properties of COVID-19 compounds and highlights the need to rule out secondary defects of compound treatment on embryogenesis. All results are available on a user friendly web-interface https://share.streamlit.io/alernst/covasc_dataapp/main/Co asc_DataApp.py that provides a comprehensive overview of all observed phenotypic effects and allows personalized search on specific compounds or group of compounds. Furthermore, the presented platform can be expanded for rapid detection of developmental side effects of new compounds for treatment of COVID-19 and further viral infectious diseases.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.06.29.547094v1" target="_blank">Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform</a>
</div></li>
<li><strong>SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity</strong> -
<div>
The glycosylation of viral envelope proteins can play important roles in virus biology and immune evasion. The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 22 N-linked glycosylation sequons and 17 O-linked glycosites. Here, we investigated the effect of individual glycosylation sites on SARS-CoV-2 S function in pseudotyped virus infection assays and on sensitivity to monoclonal and polyclonal neutralizing antibodies. In most cases, removal of individual glycosylation sites decreased the infectiousness of the pseudotyped virus. For glycosylation mutants in the N-terminal domain (NTD) and the receptor binding domain (RBD), reduction in pseudotype infectivity was predicted by a commensurate reduction in the level of virion-incorporated spike protein. Notably, the presence of a glycan at position N343 within the RBD had diverse effects on neutralization by RBD-specific monoclonal antibodies (mAbs) cloned from convalescent individuals. The N343 glycan reduced overall sensitivity to polyclonal antibodies in plasma from COVID-19 convalescent individuals, suggesting a role for SARS-CoV-2 spike glycosylation in immune evasion. However, vaccination of convalescent individuals produced neutralizing activity that was resilient to the inhibitory effect of the N343 glycan.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.06.30.547241v1" target="_blank">SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity</a>
</div></li>
<li><strong>Vaccines at Velocity: Evaluating Potential Lives Saved by Earlier Vaccination in the COVID-19 Pandemic</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Fast development of COVID-19 vaccines likely averted millions of deaths. We estimate how many more lives could have been saved if safe and effective vaccines were available earlier in the pandemic, in particular, before the epidemic waves in winter of 2020. We fit an epidemiological model informed by retrospective data and simulate counterfactual vaccination scenarios for the United Kingdom and the United States in which vaccines are available between 30 and 90 days earlier. We find that up to 1 July 2021 reductions in mortality range from 10,000 to 48,000 in the UK and 53,000 to 130,000 in the US, depending on when vaccinations start. This corresponds to a maximum of 7.1 and 4 deaths averted per 10,000 people in the UK and US respectively. We find that our model is sensitive to uncertain vaccine parameters and benefits depend on the time horizon of the analysis. However, the large average reductions we estimate suggests that it is highly cost-effective to make large investments in strategies to expedite vaccine availability.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.16.23291442v2" target="_blank">Vaccines at Velocity: Evaluating Potential Lives Saved by Earlier Vaccination in the COVID-19 Pandemic</a>
</div></li>
<li><strong>The Colloido Osmotic Pressure as a useful biomarker of fatal outcome in pregnant COVID-19 patients</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Pregnancy was considering a health condition that could support high severity in COVID-19, among others the cardiologic and respiratory systems express some physiologic change in the pregnant women and could specially affected in COVID-19. Pregnant women characteristically have an increase volume of blood, with a higher cardiac output and lower peripheral vascular resistance, these could be negative affected by hypoalbuminemia frequently observed in COVID-19. Then, an early recognition of hypoalbuminemia in pregnant women with COVID-19 would help us to predict fatal outcome. Objective: We conduct a study to analyzed the demographic, clinical, blood gas test results, laboratory and ultrasonographic doppler data in pregnant women with COVID-19 that demand medical attention for labor. Study design: Ninety-two pregnant women with COVID-19 were included in our study from may 30th 2020 to august 12th 2022, and data was analyzed in survival and fatal outcome patients. Normality test were applied to data and parametric or non-parametric test were used to determine statistical difference between or among data. Results: Demographic and clinical data were quite similar between survival and fatal outcome pregnant patients with COVID-19. Also, blood gas test shown similar results among groups (asymptomatic, mild, or severe patients who survive COVID-19 or fatal outcome patients). We observed that serum albumin was consistently low in pregnant patients with fatal outcome by COVID-19, then based on Total Protein concentration in serum we calculated the colloido-osmotic pressure and we evaluate its utility as predictor of fatal outcome. ROC analysis and Kaplan-Meier of survival curves suggest that the colloido-osmotic pressure could be a potential predictor. Also, we observed an association of low colloido-osmotic pressure and low amniotic fluid index. Conclusion: Our study suggests that early evaluation of pregnant with COVID-19 must include the calculation of colloido-osmotic pressure and the doppler analysis to early recognition of fatal outcome in pregnant women with COVID-19.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.29.23292050v1" target="_blank">The Colloido Osmotic Pressure as a useful biomarker of fatal outcome in pregnant COVID-19 patients</a>
</div></li>
<li><strong>Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
SARS-CoV-2 reinfections increased substantially after Omicron variants emerged. Large-scale community-based comparisons across multiple Omicron waves of reinfection characteristics, risk factors, and protection afforded by previous infection and vaccination, are limited, especially after widespread national testing stopped. We studied 245,895 adults &gt;=18y in the UK9s national COVID-19 Infection Survey with at least one infection (identified from positive swab tests done within the study, linked from national testing programmes, or self-reported by participants, up to their last study assessment). We quantified the risk of reinfection in multiple infection waves, including those driven by BA.1, BA.2, BA.4/5, and most recently BQ.1/CH.1.1/XBB.1.5 variants, in which most reinfections occurred. Reinfections had higher cycle threshold (Ct) values (lower viral load) and lower percentages self-reporting symptoms compared with first infections. Across multiple Omicron waves, protection against reinfection was significantly higher in those previously infected with more recent than earlier variants, even at the same time from previous infection. Protection against Omicron reinfections decreased over time from the most recent infection if this was the previous or penultimate variant (generally within the preceding year), but did not change or even slightly increased over time if this was with an even earlier variant (generally &gt;1 year previously). Those 14-180 days after receiving their most recent vaccination had a lower risk of reinfection with all Omicron variants except BA.2 than those &gt;180 days from their most recent vaccination. Reinfection risk was independently higher in those aged 30-45 years, and with either low or high Ct values in their most recent previous infection. Overall, the risk of Omicron reinfection is high, but with lower severity than first infections; reinfection risk is likely driven as much by viral evolution as waning immunity.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.29.23292043v1" target="_blank">Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population</a>
</div></li>
<li><strong>Synthesis and new evidence from the PROTECT UK National Core Study: Determining occupational risks of SARS-CoV-2 infection and COVID-19 mortality</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Introduction: The PROTECT National Core Study was funded by the UK Health and Safety Executive (HSE) to investigate routes of transmission for SARS-CoV-2 and variation between settings. Methods: A workshop was organised in Oct 2022.We brought together evidence from five published epidemiological studies that compared risks of SARS-CoV-2 infection or COVID-19 mortality by occupation or sector funded by PROTECT relating to three non-overlapping data sets, plus additional unpublished analyses relating to the Omicron period. We extracted descriptive study level data and model results. We investigated risk across four pandemic waves using forest plots for key occupational groups by time-period. Results: Results were largely consistent across different studies with different expected biases. Healthcare and social care sectors saw elevated risks of SARS-CoV-2 infection and COVID-19 mortality early in the pandemic, but thereafter this declined and varied by specific occupational subgroup. The education sector saw sustained elevated risks of infection after the initial lockdown period with little evidence of elevated mortality. Conclusions: Increased in risk of infection and mortality were consistently observed for occupations in high risk sectors particularly during the early stage of the pandemic. The education sector showed a different pattern compared to the other high risk sectors, as relative risk of infections remained high in the later phased of the pandemic, although no increased in COVID-19 mortality (compared to low-risk occupations) was observed in this sector in any point during the pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.30.23292079v1" target="_blank">Synthesis and new evidence from the PROTECT UK National Core Study: Determining occupational risks of SARS-CoV-2 infection and COVID-19 mortality</a>
</div></li>
<li><strong>Risk of cardiovascular events following COVID-19 in people with and without pre-existing chronic respiratory disease</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background COVID-19 is associated with a higher risk of cardiovascular outcomes in the general population, but it is unknown whether people with pre-existing chronic respiratory disease (CRD) have a higher risk of cardiovascular events post-COVID-19 compared with the general population and, if so, what respiratory-related risk factors may modify this risk in these people. Methods Primary and secondary care data from the National Health Service and COVID-19-specific linked data were used to define a population of adults in England with COVID-19 (index date) between 01/01/2020-30/11/2021. Adjusted Cox Proportional Hazard regression was used to quantify the association between CRD, asthma-related factors, COPD-related factors, and risk of cardiovascular events. CRD included asthma, COPD, bronchiectasis, cystic fibrosis, or pulmonary fibrosis prior to COVID-19 diagnosis. Asthma-specific factors included baseline asthma control, exacerbations, and inhaled corticosteroid (ICS) dose. COPD-specific risk factors included baseline ICS prescriptions and exacerbations. Secondary objectives quantified the impact of COVID-19 hospitalisation and vaccine dose on cardiovascular outcomes. Results Of 3,670,455 people, those with CRD had a modest higher risk of cardiovascular events (HRadj 1.11, 95%CI 1.07-1.14), heart failure (HRadj 1.15, 1.09-1.21), and pulmonary emboli (HRadj 1.20, 1.11-1.30) compared with people without CRD. In people with asthma, baseline exacerbations and high-dose ICS were associated with a higher risk of cardiovascular outcomes (HRadj 1.24, 1.15-1.34 and 1.12, 1.01-1.24, respectively). In people with COPD, exacerbations were associated with a higher risk of cardiovascular outcomes (HRadj 1.40, 1.28-1.52). Regardless of CRD, the risk of cardiovascular events was lower with increasing COVID-19 vaccine dose. Conclusions Higher risk of cardiovascular events following COVID-19 might be explained at least in part by the underlying CRD and severity of that condition. In addition, COVID-19 vaccines were beneficial to both people with and without CRD with regards to CV events.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.03.01.23286624v2" target="_blank">Risk of cardiovascular events following COVID-19 in people with and without pre-existing chronic respiratory disease</a>
</div></li>
<li><strong>Idiographic Personality Coherence: A Quasi Experimental Longitudinal ESM Study</strong> -
<div>
Personality is a study of persons. However, persons exist within contexts, and personality coherence emerges from persons in contexts. But persons and environments bidirectionally influence each other, with persons selecting into and modifying their contexts, which also have lasting influences on personality. Thus, environmental change should produce changes in personality. Alternatively, environmental changes may produce few changes. This paradoxical viewpoint is based on the idea that novel environments have no predefined appropriate way to behave, which allows preexisting personality systems to stay coherent (Caspi &amp; Moffitt, 1993). We test these two perspectives by examining longitudinal consistency idiographic personality coherence using a quasi-experimental design (N = 50; total assessments = 5,093). Personality coherence was assessed up to one year before the COVID-19 pandemic and again during lockdown. We also test antecedents and consequences of consistency, examining both what prospectively predicts consistency as well as what consistency prospectively predicts. Overall, consistency was modest but there were strong individual differences, indicating some people were quite consistent despite environmental upheaval. Moreover, there were relatively few antecedents and consequences of consistency, with the exception of some goals and domains of satisfaction predicting consistency, leaving open the question of why changes in coherence occurs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/pvfg2/" target="_blank">Idiographic Personality Coherence: A Quasi Experimental Longitudinal ESM Study</a>
</div></li>
<li><strong>Knowledge of COVID-19 Symptoms, Transmission, and Prevention: Evidence from Health and Demographic Surveillance in Southern Mozambique</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Over 230,000 COVID-19 cases and over 2,200 deaths have been reported in Mozambique though May 2023. Understanding community members9 knowledge of SARS-CoV-2 transmission and prevention is essential for directing public health interventions to reduce disease spread and improve vaccination coverage. Here, we describe knowledge of COVID-19 transmission, prevention, and symptoms among community residents in Mozambique. We conducted a cross-sectional survey among 33,087 households in a Health and Demographic Surveillance System in Manhica, Mozambique. Participants were recruited at the tail end of the Delta variant wave in September 2021 to the peak of Omicron cases in January 2022. Principal components analysis was used to create scores representing knowledge of COVID-19 symptoms, transmission, and prevention. Multiple imputation and quasi-Poisson regression were used to examine associations between demographic characteristics and sources of COVID-19 information, and knowledge of COVID-19 symptoms, transmission, and prevention. We examined whether sources of COVID-19 information mediated the relationship between educational attainment and knowledge of symptoms, transmission, and prevention. Across this rural community, 98.2%, 97.0%, and 85.1% of respondents reported knowing how COVID-19 could be prevented, that SARS-CoV-2 can cause disease, and how SARS-CoV-2 is transmitted, respectively. Most cited symptoms were cough (51.2%), headaches (44.9%), and fever (44.5%); transmission mechanisms were droplets (50.5%) or aerosol (46.9%) from an infected person; and prevention measures were handwashing (91.9%) and mask-wearing (91.8%). Characteristics associated with greater knowledge of symptoms, transmission, and prevention included having at least primary education, older age, employment, higher wealth, and Christian religion. Respondents who had had COVID-19 symptoms were also more likely to have knowledge of symptoms, transmission, and prevention. Gathering information from TV, WhatsApp, radio, and hospital mediated the relationship between educational attainment and knowledge scores. These findings support the need for outreach and for community-engaged messaging to promote prevention measures, particularly among people with low education.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.03.31.23288026v2" target="_blank">Knowledge of COVID-19 Symptoms, Transmission, and Prevention: Evidence from Health and Demographic Surveillance in Southern Mozambique</a>
</div></li>
<li><strong>Mycobiome analyses of critically ill COVID-19 patients</strong> -
<div>
Rationale: Covid-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID -19. Previously, acute respiratory distress syndrome in patients with COVID-19 has been associated with lung fungal dysbiosis, evidenced by reduced microbial diversity and Candida colonisation. Increased fungal burden in the lungs of critically ill COVID-19 patients is linked to prolonged mechanical ventilation and increased mortality. However, specific mycobiome signatures associated with severe COVID-19 in the context of survival and antifungal drug prophylaxis have not yet been determined and such knowledge could have an important impact on treatment. Objectives: To understand the composition of the respiratory mycobiome in critically ill COVID -19 patients with and without CAPA, the impact of antifungal use and its role in patient outcome. Methods: We performed a multi-national study of 39 COVID-19 patients in intensive care units (ICU) with and without CAPA. Respiratory mycobiome was profiled using ITS1 sequencing and Aspergillus fumigatus burden was further validated using qPCR. Fungal communities were investigated using alpha diversity, beta diversity, taxa prevalence and taxa abundances. Measurements and Main Results: Respiratory mycobiomes were dominated by Candida and Aspergillus. There was no significant association with corticosteroid use or CAPA diagnosis and respiratory fungal communities. Increased A. fumigatus burden was associated with mortality. The use of antifungals at ICU admission was associated with an absence of A. fumigatus. Conclusions: Our findings suggest that systemic antifungal treatment at ICU admission may be protective against A. fumigatus-associated mortality in CAPA.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.06.13.543274v2" target="_blank">Mycobiome analyses of critically ill COVID-19 patients</a>
</div></li>
<li><strong>Identification of cross-reacting IgG hotspots to prevent immune evasion of SARS-CoV-2 variants</strong> -
<div>
The major factor that shapes the global perspective for increase or diminution of successive pandemic waves of COVID-19 is the immunological protection. The SARS-CoV-2 virus constantly develops new variants, and capability of immune evasion is among the major factors that promote variant spreading in the human population. After two years of the pandemic and virus evolution, it is almost impossible to explain effects of all possible combinations different viral strains, a few types of vaccinations or new variants infecting an individual patient. Instead of variant-to-variant comparisons, identification of key protein regions linked to immune evasion could be efficient. Here we report an approach for experimental identification of SARS-CoV-2 protein regions that (i) have characteristics of cross-reacting IgG hot-spots, and (ii) are highly immunogenic. Cross-reacting IgG hot spots are regions of protein frequently recognized in many variants by cross-reacting antibodies. Immunogenic regions efficiently induce specific IgG production in SARS-CoV-2 infected patients. We determined four regions that demonstrate both significant immunogenicity and the activity of a cross-reacting IgG hot-spot in protein S, and two such regions in protein N. Their distribution within the proteins suggests that they may be useful in vaccine design and in serological diagnostics of COVID?19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.06.27.546805v1" target="_blank">Identification of cross-reacting IgG hotspots to prevent immune evasion of SARS-CoV-2 variants</a>
</div></li>
<li><strong>A Rationally Designed Antimicrobial Peptide from Structural and Functional Insight of Clostridium difficile Translation Initiation Factor 1</strong> -
<div>
A significant increase of hospital-acquired bacterial infections during the COVID-19 pandemic has become an urgent medical problem. Clostridioides difficile is an urgent antibiotic-resistant bacterial pathogen and a leading causative agent of nosocomial infections. The increasing recurrence of C. difficile infection and antibiotic resistance in C. difficile has led to an unmet need for discovery of new compounds distinctly different from present antimicrobials, while antimicrobial peptides as promising alternatives to conventional antibiotics have attracted growing interest recently. Protein synthesis is an essential metabolic process in all bacteria and a validated antibiotic target. Initiation factor 1 from C. difficile (Cd-IF1) is the smallest of the three initiation factors that acts to establish the 30S initiation complex to initiate translation during protein biosynthesis. Here we report the solution NMR structure of Cd-IF1 which adopts a typical {beta}-barrel fold and consists of a five-stranded {beta}-sheet and one short -helix arranged in the sequential order {beta}1-{beta}2-{beta}3-1-{beta}4-{beta}5. The interaction of Cd-IF1 with the 30S ribosomal subunit was studied by NMR titration for the construction of a structural model of Cd-IF1 binding with the 30S subunit. The short -helix in IF1 was found to be critical for IF1 ribosomal binding. A peptide derived from this -helix was tested and displayed a high ability to inhibit the growth of C. difficile and other bacterial strains. These results provide a clue for rational design of new antimicrobials.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.06.30.547268v1" target="_blank">A Rationally Designed Antimicrobial Peptide from Structural and Functional Insight of Clostridium difficile Translation Initiation Factor 1</a>
</div></li>
<li><strong>Mortality associated with influenza and Omicron infections in France and vaccination of healthcare workers in nursing homes</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: During the winter of 2022-2023, high rates of all-cause mortality, not seen since April 2020, were recorded in France, with excess all-cause mortality being related to the Omicron and influenza epidemics during that period. Moreover, that period saw a significant increase in the proportion of residents in long-term care facilities among cases of death in the population. Studies have found that increased influenza vaccination coverage in healthcare workers can result in a substantial reduction (up to 20%-30% during the course of select influenza seasons in the pre-pandemic period) in all-cause mortality in residents in nursing homes. Methods: We applied the previously developed methodology to estimate the contribution of influenza infections to all-cause mortality in France for the 2014-2015 through the 2018-2019 influenza seasons, and the contribution of both SARS-CoV-2 and influenza infections to all-cause mortality between week 33, 2022 through week 12, 2023. Results: For the 2014-2015 through the 2018-2019 seasons, influenza was associated with an average of 15654 (95% CI (13013,18340)) deaths, while between week 33, 2022 through week 12, 2023, we estimated 7851 (5213,10463) influenza-associated deaths and 32607 (20794,44496) SARS-CoV-2 associated deaths. The number of SARS-CoV-2-associated deaths during the Omicron epidemic was significantly higher than the number of deaths with COVID-19 listed on the death certificate or the hospitalization record; for example, between weeks 33-52 in 2022, we estimated 23983 (15307,32620) SARS-CoV-2-associated deaths in France, compared with 12811 deaths with COVID-19 listed on the death certificate, and 8639 in-hospital deaths with COVID-19 during the same period. Examination of US mortality data suggests a significant contribution of Omicron infections to mortality for cardiac disease and mental/behavioral disorders with COVID-19 not listed on the death certificate. Conclusions: Our results suggest the need for boosting influenza vaccination coverage in different population groups (including healthcare workers, particularly nurse assistants for whom influenza vaccination coverage rates in France are low), as well as for wider use of influenza antiviral medications in influenza-related respiratory hospitalizations with different diagnoses (including pneumonia). Wider detection and treatment of Omicron infections, particularly in older individuals/persons with underlying health conditions such as cardiac disease and mental/behavioral disorders, and wider use of bivalent COVID-19 boosters would be needed in the event of the recrudescence of Omicron circulation in France.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.05.23290994v2" target="_blank">Mortality associated with influenza and Omicron infections in France and vaccination of healthcare workers in nursing homes</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Probiotic and Colchicine in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Colchicine 0.5 MG;   Dietary Supplement: Probiotic Formula;   Other: Standard protocol<br/><b>Sponsor</b>:   Ain Shams University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study Evaluating SHEN26 Capsule in Patients With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: SHEN26 capsule;   Drug: SHEN26 placebo<br/><b>Sponsor</b>:   Shenzhen Kexing Pharmaceutical Co., Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Clinical Trial of Recombinant COVID-19 Bivalent (XBB+Prototype) Protein Vaccine (Sf9 Cell) in Booster Vaccination</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 Bivalent (XBB+Prototype) Protein Vaccine (Sf9 Cell) (WSK-V101C);   Biological: Recombinant COVID-19 vaccine(Sf9 Cell) (WSK-V101)<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: High dose of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell);   Biological: Low dose of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell);   Biological: control group;   Biological: Placebo group<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>LUSZ Treatment Efficacy in Hospitalized COVID-19 Patients</strong> - <b>Conditions</b>:   COVID-19;   Hospitalized COVID-19 Patients<br/><b>Interventions</b>:   Drug: Lopinavir / Ritonavir;   Drug: Remdesivir (RDV);   Drug: Tocilizumab;   Other: Corticosteroid Therapy-enhanced Standard Care (CTSC)<br/><b>Sponsors</b>:   Lebanese University;   Hospital Saydet Zgharta University Medical Center<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impact Of Sensory Re-Education Paradigm On Sensation And Quality Of Life In Patients Post-Covid 19 Polyneuropathy</strong> - <b>Condition</b>:   Post-COVID-19 Syndrome<br/><b>Interventions</b>:   Other: sensory re-education training;   Other: traditional treatment<br/><b>Sponsor</b>:   Cairo University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comprehensive Imaging Exam of Convalesced COVID-19 Patients</strong> - <b>Conditions</b>:   COVID-19;   COVID Long-Haul<br/><b>Interventions</b>:   Other: Magnetic Resonance Imaging;   Other: Ultra-High Resolution Computed Tomography (CT) Scan<br/><b>Sponsors</b>:   Johns Hopkins University;   Canon Medical Systems, USA<br/><b>Enrolling by invitation</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UNAIR Inactivated COVID-19 Vaccine as Heterologue Booster (Immunobridging Study)</strong> - <b>Conditions</b>:   COVID-19 Pandemic;   COVID-19 Vaccines<br/><b>Interventions</b>:   Biological: Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg;   Biological: CoronaVac Biofarma COVID-1 9 Vaccine 3 µg<br/><b>Sponsors</b>:   Dr. Soetomo General Hospital;   Indonesia-MoH;   Universitas Airlangga;   Biotis Pharmaceuticals, Indonesia<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Investigate the Safety, Immunogenicity of Bivalent mRNA Vaccine RQ3027 and RQ3025 as a Booster Dose in Healthy Adults</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: RQ3013;   Biological: RQ3025;   Biological: RQ3027<br/><b>Sponsors</b>:   Affiliated Hospital of Yunnan University;   Yunnan University;   Kunming Medical University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluate the Safety and Immunogenicity of Different Booster Dose Levels of Monovalent and Bivalent SARS-CoV-2 rS Vaccines in Adults ≥ 50 Years</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: NVX-CoV2540 (5, 10, 25 μg);   Biological: NVX-CoV2373 (5 μg);   Biological: Bivalent BA.4/5 Omicron subvariant<br/><b>Sponsor</b>:   Novavax<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating the Efficacy of Remdesivir for Long COVID Following a Confirmed COVID-19 Infection.</strong> - <b>Conditions</b>:   SARS-CoV-2 Infection;   COVID-19<br/><b>Intervention</b>:   Drug: Remdesivir<br/><b>Sponsors</b>:   University of Derby;   University of Exeter;   Peninsula Clinical Trials Unit;   University Hospitals of Derby and Burton NHS Foundation Trust<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Smart Sensor Combined With APP for Individualized Precise Exercise Training in Long Covid-19</strong> - <b>Conditions</b>:   Coronavirus Disease;   COVID-19;   Long Covid-19;   Telerehabilitation<br/><b>Interventions</b>:   Device: KNEESUP smart knee assistive device + KNEESUP care APP;   Device: KNEESUP care APP;   Behavioral: Healthy consulation<br/><b>Sponsor</b>:   Shang-Lin Chiang<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Open Label Extension of Efgartigimod in Adults With Post-COVID-19 POTS</strong> - <b>Condition</b>:   Post-COVID Postural Orthostatic Tachycardia Syndrome Postural Orthostatic Tachycardia Syndrome<br/><b>Intervention</b>:   Drug: Efgartigimod<br/><b>Sponsors</b>:   argenx;   Iqvia Pty Ltd<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Digital Interventions to Understand and Mitigate Stress Response</strong> - <b>Conditions</b>:   Distress, Emotional;   Stress Response Among Nursing Professionals During the COVID-19;   Stress Reaction; Acute<br/><b>Intervention</b>:   Behavioral: Digital Intervention Group<br/><b>Sponsors</b>:   Unity Health Toronto;   Toronto Metropolitan University;   University of Toronto;   University of Ontario Institute of Technology;   Boston University;   University of Ottawa;   Western University, Canada;   Centre for Addiction and Mental Health<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PREPARE-iVAC Trial</strong> - <b>Conditions</b>:   COVID-19 Vaccines;   Varicella Zoster Vaccine;   Vaccine Response;   Immunosuppression<br/><b>Intervention</b>:   Biological: COVID-19 vaccination<br/><b>Sponsors</b>:   University Medical Center Groningen;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   Radboud University Medical Center;   Erasmus Medical Center;   UMC Utrecht;   Leiden University Medical Center;   Maastricht University Medical Center;   ZonMw: The Netherlands Organisation for Health Research and Development<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein</strong> - Mutations in spike (S) protein epitopes allow SARS-CoV-2 variants to evade antibody responses induced by infection and/or vaccination. In contrast, mutations in glycosylation sites across SARS-CoV-2 variants are very rare, making glycans a potential robust target for developing antivirals. However, this target has not been adequately exploited for SARS-CoV-2, mostly due to intrinsically weak monovalent protein-glycan interactions. We hypothesize that polyvalent nano-lectins with flexibly linked…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) and severe and critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-β</strong> - Severe fever with thrombocytopenia syndrome virus (SFTSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause the hyperproduction of inflammatory cytokines, which have pathological effects in patient including severe or fatal cytokine storms. To characterize the effect of SFTSV and SARS-CoV-2 infection on the production of cytokines in severe fever with thrombocytopenia syndrome (SFTS) and COVID-19 patients, we performed an analysis of cytokines in SFTS and COVID-19…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti-Inflammatory Effects of Dexamethasone in COVID-19 Patients: Translational Population PK/PD Modeling and Simulation</strong> - Dexamethasone (DEX) given at a dose of 6 mg once-daily for 10 days is a recommended dosing regimen in patients with COVID-19 requiring oxygen therapy. We developed a population pharmacokinetic and pharmacodynamic (popPK/PD) model of DEX anti-inflammatory effects in COVID-19 and provide simulations comparing the expected efficacy of four dosing regimens of DEX. Nonlinear mixed-effects modeling and simulations were performed using Monolix Suite version 2021R1 (Lixoft, France). Published data for…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2</strong> - The continuing emergence of SARS-CoV-2 variants has highlighted the need to identify additional points for viral inhibition. Ribosome inactivating proteins (RIPs), such as MAP30 and Momordin which are derived from bitter melon (Momordica charantia), have been found to inhibit a broad range of viruses. MAP30 has been shown to potently inhibit HIV-1 with minimal cytotoxicity. Here we show that MAP30 and Momordin potently inhibit SARS-CoV-2 replication in A549 human lung cells (IC50 ~ 0.2 μM) with…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease</strong> - The SARS-CoV-2 main protease (M^(pro)) plays an essential role in the coronavirus lifecycle by catalyzing hydrolysis of the viral polyproteins at specific sites. M^(pro) is the target of drugs, such as nirmatrelvir, though resistant mutants have emerged that threaten drug efficacy. Despite its importance, questions remain on the mechanism of how M^(pro) binds its substrates. Here, we apply dynamical nonequilibrium molecular dynamics (D-NEMD) simulations to evaluate structural and dynamical…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4)</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subject to restriction by several interferon-inducible host proteins. To identify novel factors that limit replication of the virus, we tested a panel of genes that we found were induced by interferon treatment of primary human monocytes by RNA sequencing. Further analysis showed that one of the several candidates genes tested, receptor transporter protein 4 (RTP4), that had previously been shown to restrict flavivirus replication,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Characterization of SARS-CoV-2 humoral immune response in a subject with unique sampling: A case report</strong> - CONCLUSION: The findings here provide novel insights into humoral immune response characteristics associated with SARS-CoV-2 breakthrough infections.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial</strong> - CONCLUSIONS: rNAPc2 treatment in hospitalized patients with COVID-19 was well tolerated without excess bleeding or serious adverse events but did not significantly reduce D-dimer more than heparin at day 8.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Endotyping of IgE-mediated polyethylene glycol and/or polysorbate 80 allergy</strong> - CONCLUSION: PEG and PS80 cross-reactivity is determined by IgE recognizing short PEG motifs, whilst PS80 mono-allergy is PEG-independent. PS80 skin test positivity in PEG allergics was associated with a severe and persistent phenotype, higher serum PEG-specific IgE levels and enhanced BAT reactivity. Spherical PEG-exposure via LNP enhances BAT sensitivity through increased avidity. All PEG and/or PS80 excipient allergic patients can safely receive SARS-CoV-2 vaccines.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hindered visibility improvement despite marked reduction in anthropogenic emissions in a megacity of southwestern China: An interplay between enhanced secondary inorganics formation and hygroscopic growth at prevailing high RH conditions</strong> - The PM(2.5)-bound visibility improvement remains challenging in China despite vigorous control on anthropogenic emissions in recent years. One critical issue could exist in the distinct physicochemical properties especially of secondary aerosol components. Taken the COVID-19 lockdown as an extreme case, we focus on the relationship between visibility, emission cuts, and secondary formation of inorganics with changing optical and hygroscopic behaviors in Chongqing, a representative city…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anthracyclines inhibit SARS-CoV-2 infection</strong> - Vaccines and drugs are two effective medical interventions to mitigate SARS-CoV-2 infection. Three SARS-CoV-2 inhibitors, remdesivir, paxlovid, and molnupiravir, have been approved for treating COVID-19 patients, but more are needed, because each drug has its limitation of usage and SARS-CoV-2 constantly develops drug resistance mutations. In addition, SARS-CoV-2 drugs have the potential to be repurposed to inhibit new human coronaviruses, thus help to prepare for future coronavirus outbreaks….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Statins: Beneficial Effects in Treatment of COVID-19</strong> - The recent viral disease COVID-19 has attracted much attention. The disease is caused by SARS-CoV-19 virus which has different variants and mutations. The mortality rate of SARS-CoV-19 is high and efforts to establish proper therapeutic solutions are still ongoing. Inflammation plays a substantial part in the pathogenesis of this disease causing mainly lung tissue destruction and eventually death. Therefore, anti-inflammatory drugs or treatments that can inhibit inflammation are important…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>mLST8 is essential for coronavirus replication and regulates its replication through the mTORC1 pathway</strong> - Coronaviruses (CoVs), which pose a serious threat to human and animal health worldwide, need to hijack host factors to complete their replicative cycles. However, the current study of host factors involved in CoV replication remains unknown. Here, we identified a novel host factor, mammalian lethal with sec-13 protein 8 (mLST8), which is a common subunit of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), and is critical for CoV replication. Inhibitor and knockout (KO) experiments revealed…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Validity of Rapid Antibody Testing for COVID-19 Vaccine in Homeless People</strong> - (1) Background: There is a paucity of data regarding the validity of rapid antibody testing for SARS-CoV-2 vaccine response in homeless people worldwide. The objective of this study was to evaluate a rapid SARS-CoV-2 IgM/IgG antibody detection kit as a qualitative screen for vaccination in homeless people. (2) Methods: This study included 430 homeless people and 120 facility workers who had received one of BNT162b2, mRNA-1273, AZD1222/ChAdOx1, or JNJ-78436735/AD26.COV2.5 vaccines. They were…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Correlation between Clinical Characteristics and Antibody Levels in COVID-19 Convalescent Plasma Donor Candidates</strong> - COVID-19 convalescent plasma (CCP) with high neutralizing antibodies has been suggested in preventing disease progression in COVID-19. In this study, we investigated the relationship between clinical donor characteristics and neutralizing anti-SARS-CoV-2 antibodies in CCP donors. COVID-19 convalescent plasma donors were included into the study. Clinical parameters were recorded and anti-SARS-CoV-2 antibody levels (Spike Trimer, Receptor Binding Domain (RBD), S1, S2 and nucleocapsid protein) as…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Titan Submersible Implosion Was “an Accident Waiting to Happen”</strong> - Interviews and e-mails with expedition leaders and employees reveal how OceanGate ignored desperate warnings from inside and outside the company. “It’s a lemon,” one wrote. - <a href="https://www.newyorker.com/news/a-reporter-at-large/the-titan-submersible-was-an-accident-waiting-to-happen">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Could Putin Lose Power?</strong> - Regime stability is a funny thing. One day it’s there; the next day, poof—it’s gone. - <a href="https://www.newyorker.com/news/the-weekend-essay/could-putin-lose-power">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why the Champions of Affirmative Action Had to Leave Asian Americans Behind</strong> - The original concept in pursuit of diversity was vital and righteous. The way it was practiced was hard to defend. - <a href="https://www.newyorker.com/news/our-columnists/why-the-champions-of-affirmative-action-had-to-leave-asian-americans-behind">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beyoncé on Tour, and Russia’s No-Good, Very Failed Coup</strong> - Masha Gessen and Joshua Yaffa on the aftermath of the “coup” by the Wagner Group leader, and what lies ahead for Vladimir Putin. Plus, Carrie Battan on the summer’s hottest ticket. - <a href="https://www.newyorker.com/podcast/the-new-yorker-radio-hour/beyonce-on-tour-and-russias-no-good-very-failed-coup">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Much Hotter Can Texas Get?</strong> - The state endures high temperatures, but not usually so early in the summer, or for so long. Something is different. - <a href="https://www.newyorker.com/news/daily-comment/how-much-hotter-can-texas-get">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>2023’s best books (so far)</strong> -
<figure>
<img alt="A graphic of the book covers included on the list, including “Spare,” (a close-up of Prince Harry’s face), “Big Swiss” (a quasi-painterly image of a Swiss-looking woman with her mouth open in a possible orgasm), and Flawless (a close-up of a Korean woman’s face). " src="https://cdn.vox-cdn.com/thumbor/4PVTLDjJzolznGdEk_sEdpqUTTk=/240x0:1680x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72418638/Vox_BestBooksSoFar_PaigeVickers.0.jpg"/>
<figcaption>
Paige Vickers / Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
From shipwrecks to hijackings to sex comedies, these are the best books of the first half of 2023.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Lj773j">
The year is half over now. We’ve seen the swell of austere literary fiction in February, the first crop of lazy beach novels for summer. There have been big buzzy memoirs published, and cookbooks, and essays. Now, before the overwhelming surge of fall prestige book season, let’s stop and take stock of all the good books the year has brought us so far.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mT01eZ">
As Vox’s book critic, I take a great bite out of all the books that come out every year. In the first half of the year, these have been my favorites: Brainy sex comedies. Environmentalist cookbooks. Shipwrecks and con artists and monsters and yes, why not have another look at that big buzzy memoir. Here are the 11 best books I’ve read in the first half of 2023.
</p>
<h3 id="6ZPZ8K">
Fiction
</h3>
<div class="c-float-left">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/uqR3PgueFLm8tmRx7FT0_Hu4oig=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24760533/big_swiss_9781982153083_hr.jpg"/> <cite>Scribner Book Company</cite>
<figcaption>
<em>Big Swiss</em> by Jen Beagin.
</figcaption>
</figure>
</div>
<h4 id="7FLY8c">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fbig-swiss-jen-beagin%2F18375010&amp;xcust=BestBooksOf2023"><em>Big Swiss</em></a> by Jen Beagin
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KFoKY4">
<em>Big Swiss</em> is the wittiest of this year’s novels, and the quirkiest, too. A breakout hit from Jen Beagin that <a href="https://www.vulture.com/2023/02/jen-beagins-novel-big-swiss-sparked-a-bidding-war.html">inspired a bidding war for its film rights</a>, <em>Big Swiss</em> concerns Greta, a medical transcriptionist. Greta is obsessed with a woman whose therapy sessions she transcribes, a mystery blonde she has dubbed Big Swiss.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oy29n1">
Big Swiss is a married gynecologist talking to a therapist because she’s never had an orgasm. She also survived a brutal assault from a man who’s about to get out of prison, but she’s not there to talk about that: “I’m not one of those trauma people.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ewCo7p">
Greta, transfixed, tracks Big Swiss down at the dog park. “You must get this a lot,” Greta says, “but would you mind taking a quick look at this thing on my labia?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ryyUlo">
<em>Big Swiss</em> is a romp of a book, a study of trauma that disdains the <a href="https://www.newyorker.com/magazine/2022/01/03/the-case-against-the-trauma-plot">trauma plot</a>, a sex comedy with deep layers. Beagin’s sentences are so dryly funny they’re ready to snap like crackers, but she never loses sight of the humanity of her odd, lovable characters. Also, there are miniature donkeys.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GI4dpi">
<em>Read if you dream of</em>: the first season of <em>Killing Eve</em> but with more dogs, less scatological Ottessa Moshfegh, more warm-hearted Elif Batuman.
</p>
<h4 id="YtOEF5">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fthe-guest-emma-cline%2F18762095&amp;xcust=BestBooksOf2023"><em>The Guest</em></a> by Emma Cline
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IxxbOE">
My teeth gnashed unceasingly while I read <em>The Guest</em>, Emma Cline’s delicious follow-up to her 2016 novel <a href="https://www.vox.com/2016/6/14/11925192/girls-emma-cline-cults-teen-girl-friendships"><em>The Girls</em></a>. I was too tense to do anything but let them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ajOZzw">
<em>The Guest</em> is set in the rarified world of the Hamptons, where everything is beautiful or at the very least expensive, and none of it quite belongs to Alex, the titular guest. Alex is a sex worker whose quasi-client, quasi-boyfriend, Simon, has thrown her out of his lavish Hamptons beach house. The problem is, Simon is currently Alex’s only client; at 22, she’s finding the rest of her regulars have started to dry up. She’s in debt, and she needs him. So she decides to make her own way in the Hamptons for a week and then see if Simon softens up toward her. But in the gated communities Simon frequents, it’s not that easy to be a guest.
</p>
<div class="c-float-right">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/wDF9VMRfTzUj3ON9YSoDiUCNRYU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24760537/9780812998627.jpg"/> <cite>Random House</cite>
<figcaption>
<em>The Guest</em> by Emma Cline.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZBtL7u">
Alex’s superpower is her ability to make herself fit in nearly anywhere. “That was the point of Alex,” Cline writes, “to offer up no friction whatsoever.” Marshaling her status as a well-dressed and pretty young white woman, she schemes her way into country clubs and house parties — until, inevitably, she pushes her luck too far and gets kicked out.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v52Y3s">
With flat, understated sentences, Cline keeps us crammed and immobile in the vacant confines of Alex’s mind. In chapter after chapter, Alex first systematically empties herself of any opinions or thoughts of her own in order to become the kind of woman her marks require of her, and then impulsively lashes out and creates friction. Alex is a creature of instinct who never seems to quite understand what she’s doing, but in Cline’s precise, elegant prose, we can see how heavily Alex bears the burden of being a woman with no needs of her own.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jCURmv">
<em>Read accompanied by</em>: a Negroni, unsweetened black tea, very dark chocolate.
</p>
<h4 id="Fcjjzb">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fvintage-contemporaries-dan-kois%2F18727238&amp;xcust=BestBooksOf2023"><em>Vintage Contemporaries</em></a> by Dan Kois
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4OluxR">
<a href="https://www.vox.com/culture/23577902/vintage-contemporaries-review-dan-kois"><em>Vintage Contemporaries</em></a> is a thoroughly charming and warm-hearted novel by Slate book critic Dan Kois. It concerns two best friends, both living in the bohemian East Village of 1991, both named Emily. One of them is brash and bold and wants to direct plays; the other is a more conventional follower who wants to write books. Kois follows them over the course of 14 years, tracking their friendship and dreams as they evolve along with New York itself.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CgGNMr">
I keep wanting to describe <em>Vintage Contemporaries</em> as a love letter and then changing my mind as to whom the love letter is for. For the great domestic novelist Laurie Colwin, whose influence looms large over one Emily’s career. For the East Village of the early 1990s, when artists squatted in abandoned lofts. For editing and dramaturgy as creative artforms in their own rights. For old friends who know us longer than anyone. For all of the above, and more.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I4r8AD">
<em>Read if you like</em>: Laurie Colwin, semi-ironic viewings of <em>Beaches</em>, Veselka pierogies.
</p>
<aside id="wYoXJI">
<div>
</div>
</aside>
<h4 id="QnBYoy">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fwhite-cat-black-dog-stories-kelly-link%2F18600074&amp;xcust=BestBooksOf2023"><em>White Cat, Black Dog</em></a> by Kelly Link
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wcWll3">
Have you ever spent a long afternoon in an art museum and walked out afterward to find that the world looks different than it did when you walked in; different, and more beautiful? As though the museum has trained your eye to find beauty more efficiently. Reading Kelly Link is like that: When you close the book, the world you return to is stranger and, yes, more beautiful than the one you left behind.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nvk1iH">
<a href="https://www.vox.com/culture/23672639/white-cat-black-dog-kelly-link-review"><em>White Cat, Black Dog</em></a> is a collection of slantwise fairy tales reimagined as short stories. Link gives you “Hansel and Gretel” with vampires and spaceships; “Tam Lin” at an English estate house; “East of the Sun, West of the Moon” on the Upper West Side. Her retellings are thoroughly modern, but she’s able to preserve the strange, shivery emotional core of the originals so that all of them take place in a world regimented by rules that no one will ever quite explain to you.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5oytxh">
<em>Read alongside</em>: Sondheim’s <em>Into the Woods</em>, Robin McKinley’s <em>Rose Daughter</em>, Pamela Dean’s <em>Tam Lin.</em>
</p>
<aside id="ELfKY3">
<div>
</div>
</aside>
<h3 id="qVMKUi">
Nonfiction
</h3>
<div class="c-float-left">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/pk3sI21ODTbPMIBTDGkipTJstg4=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24760547/the_everlasting_meal_cookbook_9781476799667_hr.jpg"/> <cite>Scribner Book Company</cite>
<figcaption>
<em>The Everlasting Meal Cookbook</em> by Tamar Adler.
</figcaption>
</figure>
</div>
<h4 id="2vnz7o">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fan-everlasting-meal-cookbook-recipes-for-leftovers-a-z-tamar-adler%2F18563116&amp;xcust=BestBooksOf2023"><em>The Everlasting Meal Cookbook: Leftovers A-Z </em></a>by Tamar Adler
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0G687d">
In 2012, Tamar Adler published <em>An Everlasting Meal</em>, a sort of updated take on the M.F.K. Fisher classic <a href="https://www.vox.com/culture/2020/3/23/21181700/coronavirus-how-to-cook-a-wolf-mfk-fisher"><em>How to Cook a Wolf</em></a> that focused on solving <a href="https://www.vox.com/videos/2017/5/9/15594598/food-waste-dumbest-environmental">the environmental problem of food waste</a> by using up all your waste ingredients. The end of every meal, Adler argued in her mannered-in-a-good-way prose, should form the beginning of the next: last night’s roast chicken and vegetables should become the bones and the peels that make today’s stock; the stock can enrich the grain bowl that tomorrow will become fried rice.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ze2Kx2">
This year, Adler has published <em>The Everlasting Meal Cookbook</em>, the how-to guide that fleshes out the theory of her last book. It takes the form of a vast index of ingredients you might have left over from some other purpose, and all the ways Adler suggests you might salvage them for a new use. You already know that overripe bananas can become banana bread, but Adler is here to tell you that green bananas can become curry or tostones, and banana peels can be dry-fried into thoran.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QNoKw5">
Adler’s prose is elegant and delighted at the same time, delighted with food and thrift and her own ingenuity. She can tell you what to do with almost anything, but most compelling are her suggestions for junk food: to simmer leftover french fries with cream and garlic and mash them; to put your leftover chips and onion dip into an omelet. This is a book that fights for environmentalism with hedonism.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zIE1ba">
<em>Read if you</em>: keep meaning to figure out how to compost, are a fan of M.F.K. Fisher, always optimistically buy too many greens.
</p>
<h4 id="WBHODt">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fall-the-beauty-in-the-world-the-metropolitan-museum-of-art-and-me-patrick-bringley%2F18667811&amp;xcust=BestBooksOf2023"><em>All the Beauty in the World: The Metropolitan Museum of Art and Me</em></a> by Patrick Bringley
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AkiNUR">
After Patrick Bringley lost his older brother in 2008, he decided to take the most straightforward job he could think of in the most beautiful place he knew. He left his job at the New Yorker’s events department and spent the next 10 years as a security guard at the Metropolitan Museum of Art.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vEGL1c">
<a href="https://www.vox.com/culture/23597606/patrick-bringley-interview-all-the-beauty-in-the-world-metropolitan-museum-of-art-met-grief"><em>All the Beauty in the World</em></a> is Bringley’s memoir of his time at the Met. It chronicles the secrets he learned there, how it taught him to look at art, and how the beauty of art helped to heal his broken heart. It’s a book for everyone who has ever wanted, <a href="https://www.vox.com/culture/2017/7/24/16004090/mixed-up-files-of-mrs-basil-e-frankweiler-50th-anniversary-met-museum">like Claudia and Jamie Kincaid</a>, to run away to your favorite museum and never look back.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bp5W72">
<em>Read while</em>: choosing the museum where you would most like to Frankenweiler.
</p>
<aside id="EEgUPD">
<div>
</div>
</aside>
<h4 id="ODc2pR">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fmonsters-a-fan-s-dilemma-claire-dederer%2F18668606&amp;xcust=BestBooksOf2023"><em>Monsters: A Fan’s Dilemma</em></a> by Claire Dederer
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OcDRkn">
Since the explosive just-post-Weinstein days of 2017, much ink has been spilled over the problem of <a href="https://www.vox.com/culture/2018/10/11/17933686/me-too-separating-artist-art-johnny-depp-woody-allen-michael-jackson-louis-ck">separating art from artist</a>. Little of it, though, has been particularly helpful. In <a href="https://www.vox.com/the-gray-area/23768672/claire-dederer-interview-monsters-a-fans-dilemma-me-too"><em>Monsters</em>, critic Claire Dederer</a> dwells provocatively in the ambiguities of the problem: You love the art and can’t unlove it. You also can’t stop thinking about the horrible things the artist did. So then <em>now</em> what?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1hVuJg">
Dederer starts from the ground floor, with the definitions. What does she mean by <em>monster</em>? What does she mean by <em>we</em>? What does she mean by <em>genius</em>? She traces the rise of the idea of the artistic genius and the remarkable liberties we grant them, and she puzzles through the problem of how audiences respond as, again and again, our geniuses misbehave. Required reading if you’ve ever felt ambivalent about watching <em>Annie Hall</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Pl1BRf">
<em>Read equipped with:</em> the annotation implement of your choice for scribbling notes (I myself am a mechanical pencil girl).
</p>
<aside id="PrRzDM">
<div>
</div>
</aside>
<h4 id="8P7Ge2">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fthe-wager-a-tale-of-shipwreck-mutiny-and-murder-david-grann%2F18732445&amp;xcust=BestBooksOf2023"><em>The Wager: A Tale of Shipwreck, Mutiny and Murder</em></a> by David Grann
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ee9aOg">
David Grann is the rare nonfiction writer whose tightly paced and rigorously documented history books are anticipated as though they were Stephen King novels. His 2018 book, <em>Killers of the Flower Moon: The Osage Murders and the Birth of the FBI</em>, was a No. 1 New York Times bestseller and adapted into a Martin Scorsese movie. His latest book, <em>The Wager</em>, is about a doomed 18th-century naval voyage spurred on by hubris and ending in violent disaster. If it doesn’t read quite like it’s ready to be a Scorsese flick, that’s because there’s so much there that I want it to get adapted into a prestige TV miniseries instead.
</p>
<div class="c-float-right">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/adcAREztTpb65PPKWkiO2Bi4Bvw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24760539/9780385534260.jpg"/> <cite>Doubleday Books</cite>
<figcaption>
<em>The Wager</em> by David Grann.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AJWtQY">
The British warship the Wager sails out of London in 1740 under the absurdly named War of Jenkins’ Ear. It was a clash of colonial forces, with Spain and England grappling for control of the New World. The Wager’s mission was to make its way south, down across the hellish and near-impassible Cape Horn below the southernmost tip of South America, and then back up north to the coast of Chile. There it would capture a Spanish galleon loaded with gold.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OY5vkG">
Instead, the crew of the Wager develops scurvy and typhus. The ship founders and sinks off the coast of Patagonia. Survivors languish on a desert island, starving and freezing. One of them finds and adopts a dog; the other sailors eat it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u1zhmP">
At the heart of the book is a great clash of wills. The striving and aristocratic Captain Cheap wants the crew to press on to Chile after their mission. The charismatic gunner John Bulkeley wants to return home to England. They vie against each other for control of the remaining crew, well beyond the point at which their struggle turns bloody.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="O1LG3A">
One of Grann’s great strengths is his ability to toggle between narrative scales. He knows the engine of the story is the fight between the personalities of Cheap and Bulkeley, and drawing from their diaries and letters, he presents each character to the reader as a fully rendered human being. He also never lets us forget that the whole disaster was sparked by imperial greed, and that the colonial striving of Britain and Spain would lead to many more disasters like it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7UQdFE">
<em>Read accompanied by</em>: dark red wine and a good basket of well-salted French fries.
</p>
<h4 id="QFmmoX">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fmy-hijacking-a-personal-history-of-forgetting-and-remembering-martha-hodes%2F19257439&amp;xcust=BestBooksOf2023"><em>My Hijacking: A Personal History of Forgetting and Remembering</em></a> by Martha Hodes
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oEQ4DK">
In 1970, the Popular Front for the Liberation of Palestine hijacked a group of commercial airplanes flying in and out of Israel. They landed the planes in the Jordan desert on a makeshift runway of sand and held their hostages there, confined to the planes, for a week. Martha Hodes was one of the hostages. She was 12 years old at the time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K4HE3Y">
Today, Hodes is a historian at NYU. Some years ago, she writes, she realized that she had very little memory of the experience of being hijacked. She must have been afraid and sad at the time, but when she thought of the hijacking, she felt as though it had happened to someone else. The emotion was long-buried, so that all that remained of the experience was that every time she walked into an airport, she was struck with the urge to cry.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LWAFkw">
In the richly emotional and elegantly constructed <em>My Hijacking</em>, Hodes puts her historian’s training to use to reconstruct the events of the hijacking. She aims to get a greater sense of what she lived through 50 years ago, and see if by doing so, she can reconnect to all the emotions her childhood self tamped down. With novel-like pacing and incredible psychological complexity, <em>My Hijacking</em> is an unflinching search for all the bad feelings we’d prefer not to look at.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HHl6Lb">
<em>Read alongside</em>: Yezid Sayigh’s <em>Armed Struggle and the Search for State: The Palestinian National Movement, 1949-1993</em>
</p>
<div class="c-float-left">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/j4JrbPXTQgzmlPWXjecDYsf4-9w=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24760543/9780593184189.jpg"/> <cite>Dutton</cite>
<figcaption>
<em>Flawless</em> by Elise Hu.
</figcaption>
</figure>
</div>
<h4 id="yYEsJ0">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fflawless-lessons-in-looks-and-culture-from-the-k-beauty-capital-elise-hu%2F18848841&amp;xcust=BestBooksOf2023"><em>Flawless: Lessons in Looks and Culture from the K-Beauty Capital</em></a> by Elise Hu
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FNaEaJ">
NPR host Elise Hu moved to South Korea in 2015 to establish a new bureau for NPR. For Hu, American born and of Chinese descent, the culture shock was massive: the shining modernity of Seoul, the technology — and the beauty culture.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jgvvVr">
K-beauty is a massive international industry, with South Korea third in the world behind the US and France as an exporter of cosmetics and skin care. It has by far the most plastic surgeons per capita of any country in the world. Gift certificates for plastic surgery are a common post-graduation gift.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D1dIVQ">
Korean beauty ideals are rigid, but Hu is careful not to demonize those who spend their money and time trying to meet them: it is, she points out, a wholly rational economic decision in a culture where most job applications require headshots. Instead, Hu tracks the social, political, and economic results of a beauty industry big enough to reshape a country. Her ability to lay out a highly rigid and codified standard of beauty in a different culture defamiliarizes our own enough to make its outlines and paradoxes plain.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yj2xWO">
<em>Read if you dream of</em>: someone finally sitting you down and explaining exactly how <a href="https://www.newyorker.com/culture/decade-in-review/the-age-of-instagram-face">Instagram Face</a> became a thing.
</p>
<h4 id="7UxSPg">
<a href="https://go.skimresources.com?id=1025X1701643&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fp%2Fbooks%2Fspare-prince-harry-the-duke-of-sussex%2F18815444&amp;xcust=BestBooksOf2023"><em>Spare</em></a> by Prince Harry, the Duke of Sussex
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1ukS5n">
<a href="https://www.vox.com/culture/23550867/spare-review-prince-harry"><em>Spare</em></a> is a book that defies killjoy distinctions like “good” and “bad,” “petty” and “open-minded.” Prince Harry suffers, he settles scores, he walks you through the process of applying his mother’s lip balm to his arctic-wind-chapped penis. One-third of this book is a gripping account of how the power of the monarchy warps and deforms family dynamics; one-third is juicy gossip about tripping on mushrooms with Courteney Cox; and the final third is unmodulated oversharing that goes well beyond the limits of what anyone ever wanted to know about Prince Harry. The combination is weird, at times off-putting, and undeniably fascinating. It’s not like any memoir you’ve ever read before.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kaim4O">
<em>Read equipped with</em>: a list of the people who have wronged you and a red Sharpie so you can plot your revenge like Harry.
</p>
<aside id="kNVpaQ">
<div>
</div>
</aside></li>
<li><strong>The unusual factors behind the extraordinary heat across the southern US</strong> -
<figure>
<img alt="An EMT with his back to the camera holds a case of water above his head. An ambulance is seen in the background. " src="https://cdn.vox-cdn.com/thumbor/43AHYyQpxqvHiY99sHX0bU0PHok=/0x0:7339x5504/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72418595/GettyImages_1504599925.0.jpeg"/>
<figcaption>
First responders in Eagle Pass, Texas, stock up on water amid a severe heat wave in the region. | Brandon Bell/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Fast-moving air 8 miles in the sky is pinning hot air over the South, driving the heat index into triple digits.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2Dnw5y">
The South is no stranger to heat, but the temperatures and humidity right now are testing even the hardiest denizens of Dixie as the hot weather stretches into a third week.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0PlDjt">
The heat wave along the Gulf Coast, stretching over Arkansas, Mississippi, Louisiana, Oklahoma, New Mexico, Texas, and Mexico, is straining the limits of infrastructure and human survival.
</p>
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According to the <a href="https://www.weather.gov/mkx/heatwaves">National Weather Service</a>, extreme heat is the number one weather-related killer in the US. The recent weather has already proven dangerous and <a href="https://globalnews.ca/news/9800736/at-least-14-dead-in-texas-louisiana-as-heat-wave-scorches-southern-u-s/">deadly</a> in places like Texas, which set an <a href="https://www.chron.com/news/houston-texas/article/texas-heat-wave-ercot-18172949.php">all-time energy demand record</a> this week as millions across the state switched on fans and air conditioners to cope with triple-digit temperatures. The heat in Arkansas followed <a href="https://www.fox16.com/news/arkansas-storm-team-blog-massive-hail-multiple-tornadoes-extreme-heat-its-june-in-arkansas/">tornadoes, high winds, and hail</a> that <a href="https://www.arkansasleader.com/articles/race-to-restore-power-before-heat-wave-storms-damage-straining-utilities/">knocked out power</a> for <a href="https://www.entergynewsroom.com/storm-center/article/entergy-arkansas-storm-update-6-28-23-11-30-m/">62,000 customers</a> last week.
</p>
<div id="QS2lto">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
️ ️Here’s yet another way to say, “It’s been hot.” We’ve had excessive heat warnings for two weeks straight! We’ve broken several high temperature records and had incredibly high dewpoint values. <a href="https://twitter.com/hashtag/txwx?src=hash&amp;ref_src=twsrc%5Etfw">#txwx</a> <a href="https://twitter.com/hashtag/stxwx?src=hash&amp;ref_src=twsrc%5Etfw">#stxwx</a> <a href="https://twitter.com/hashtag/ItsHot?src=hash&amp;ref_src=twsrc%5Etfw">#ItsHot</a> <a href="https://t.co/rfm4rPkfBO">pic.twitter.com/rfm4rPkfBO</a>
</p>
— NWS Corpus Christi (<span class="citation" data-cites="NWSCorpus">@NWSCorpus</span>) <a href="https://twitter.com/NWSCorpus/status/1673402823852322816?ref_src=twsrc%5Etfw">June 26, 2023</a>
</blockquote></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0p7y0c">
The recent sweltering weather stands out for its timing, its severity, and its duration. Parts of Louisiana issued excessive heat warnings <a href="https://globalnews.ca/news/9800736/at-least-14-dead-in-texas-louisiana-as-heat-wave-scorches-southern-u-s/">earlier in the year</a> than they’ve ever done before.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jHRf3Q">
The 100-degree-plus temperatures are a function of normal summer weather on top of unusual atmospheric patterns and global temperature cycles aligning in their hot phases. The southern US also has some unique features that are enhancing the heat. All the while, the planet as a whole is warming up.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3LjcQp">
Heat waves are also <a href="https://www.bloomberg.com/news/articles/2023-06-13/heat-scorches-europe-as-southern-spain-temperature-to-reach-45c-this-month#xj4y7vzkg">baking other parts of the world</a>, and many places have already <a href="https://www.cnn.com/2023/06/08/asia/heat-wave-siberia-climate-intl/index.html">broken temperature records</a> before summer is in full swing. Some of the drivers behind this weather are going to gather strength through the year, so 2023 is poised to become the hottest year on record for the planet.
</p>
<h3 id="hahey5">
How the jet stream is fueling the extreme heat
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="52PWD1">
Heat waves are typically defined as sustained temperatures above the 95th percentile for a region. That means that the temperatures that count as a heat wave are lower in Alaska than they are in Arkansas. “Keep in mind, it’s always hot in south Louisiana in the summer,” <a href="https://lsu.edu/ga/people/faculty/barry-d-keim/">Barry Keim</a>, Louisiana’s state climatologist and a professor at Louisiana State University, told Vox.
</p>
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Stretches of excessive heat usually follow a formula: A high-pressure system — where atmospheric pressure above an area increases — creates a column of air that heats up and dries out as it sinks. This drives clouds away, allowing the sun to heat up the ground unobstructed, with the sinking air acting as a heat dome holding the hot air in place over several days.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rz6NPy">
But there are several other variables amplifying this formula right now. One of them is the <a href="https://www.noaa.gov/jetstream/global/jet-stream">jet stream</a>, or rather, jet streams. These are bands of air currents blowing west to east at 275 miles per hour or more, gusting 4 to 8 miles above the Earth’s surface. They usually form circles around the planet and act as boundaries between warm and cold air in the sky. In the Northern Hemisphere, the main streams are the polar jet, ensconcing cold air at the North Pole, and the subtropical jet, holding warm equatorial air at bay. However, the streams can meander and blur together. “If you look at any particular day, it’s not always clear that there’s two distinct streams,” <a href="https://www.eoas.ubc.ca/people/rachelwhite">Rachel White</a>, an atmospheric scientist at the University of British Columbia, told Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uJHT2c">
These undulations are known as <a href="https://oceanservice.noaa.gov/facts/rossby-wave.html">Rossby waves</a>. Right now, the jet streams appear to be following a roller coaster track over North America rather than neat, straight lines. “It’s more ‘wave’ than ‘jet’ right now,” White said.
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In particular, there appears to be a northward bulge in the jet stream extending over the southern US. That’s holding a high-pressure system in place. “When that pattern persists over the same region for a period of days, that’s how you get a heat wave,” <a href="http://www.met.psu.edu/people/sas405">Steve Seman</a>, an assistant teaching professor at Pennsylvania State University, said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jk1nXu">
In this satellite image, you can see a patch of clear air over the southern US, bounded by a ridge of clouds:
</p>
<figure class="e-image">
<img alt="Satellite image of clouds over the southern US." src="https://cdn.vox-cdn.com/thumbor/1I2Qq_jx2siQ9bQLu52nr4xQ8Q4=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24763841/1250x750.jpeg"/> <cite><a class="ql-link" href="https://climatereanalyzer.org/wx/rad-sat/" target="_blank">Climate Reanalyzer/NOAA</a></cite>
<figcaption>
A bend in the jet stream is holding clouds back from the southern US and trapping a high-pressure system in place, driving the ongoing heat wave.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EiQGSn">
On the other side of that hump, the weather is much cooler, as seen in this temperature map:
</p>
<figure class="e-image">
<img alt="Map of high temperatures in the continental US on June 30, 2023." src="https://cdn.vox-cdn.com/thumbor/WwtoY0SXneQ-a60tqDseoxDEEEg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24763933/MaxT1_conus.png"/> <cite><a class="ql-link" href="https://graphical.weather.gov/sectors/conus.php" target="_blank">NOAA/National Weather Service</a></cite>
<figcaption>
A patch of severe heat in the southern US is surrounded by cooler regions.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yKoG5w">
“Under the ridge, where we are, we’ve had the heat. So in that sense, the jet stream is responsible for our weather, but at the same time responsible for the cooler weather on either side,” <a href="https://atmo.tamu.edu/people/profiles/faculty/nielsen-gammonjohn.html">John Nielsen-Gammon</a>, the Texas state climatologist and a professor of atmospheric sciences at Texas A&amp;M University, told Vox. “If we just had high pressure extending across all of the southern US, we wouldn’t have gotten the high temperatures that we saw, because the more localized ridge produces a stronger sinking of air and also allows for the clockwise recirculation of air.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P0JAjQ">
But right along that ridge, there’s a lot of rollicking weather. The rushing jet stream can draw air and moisture upward, fueling <a href="https://www.rmets.org/metmatters/what-are-convective-storms">convective storms</a>. “Those areas have been very active with storm activity: Tornadoes, high winds, wind damage, and hail have taken place,” Keim said. “Every place to the south of that boundary is basking in very high heat and humidity levels.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nBDv7C">
Another big factor here is that the world is in a strong <a href="https://www.vox.com/climate/23738846/el-nino-2023-weather-heat-wave-climate-change-disaster-flood-rain">El Niño</a> this year. This is the warm phase of the Pacific Ocean’s temperature cycle, where the sea surface heats up and starts to spread along the equator. That warmer water in turn shifts weather patterns, bringing more rain to some areas, drought to others, and generally more hot weather around the world.
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In the southern US, El Niño usually makes the subtropical jet stream more active in the winter, bringing cooler and wetter than average weather to the Gulf Coast. “Since this El Niño has already kicked in, that subtropical jet that we know is normally hyperactive in the winter, we’re actually seeing this hyperactivity taking place in the summer when normally we don’t even notice [it],” Keim said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cUlkws">
Confusingly, wobbly jet streams can induce the opposite effect, too. Rather than letting warm air encroach northward, waves can let cold air drift southward. In 2021, waves in the polar jet stream spilled chilly Arctic air over the US, leading to a <a href="https://www.vox.com/22287295/texas-uri-climate-change-cold-polar-vortex-arctic">cold snap in Texas</a>. “It’s sort of the other side of the same coin,” White said.
</p>
<div id="iN6uHc">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Confused about the <a href="https://twitter.com/hashtag/PolarVortex?src=hash&amp;ref_src=twsrc%5Etfw">#PolarVortex</a>? Usually a strong jet stream confines Arctic air to the north, stabilized by a big difference in temperature between low and high latitudes. The smaller the difference in temperature, the more the wind belts meander (Via <a href="https://twitter.com/RemoteLongitude?ref_src=twsrc%5Etfw"><span class="citation" data-cites="RemoteLongitude">@RemoteLongitude</span></a> &amp; <a href="https://twitter.com/NOAA?ref_src=twsrc%5Etfw"><span class="citation" data-cites="NOAA">@NOAA</span></a>) <a href="https://t.co/GEpzwjw1dS">pic.twitter.com/GEpzwjw1dS</a>
</p>
— UN Climate Change (<span class="citation" data-cites="UNFCCC">@UNFCCC</span>) <a href="https://twitter.com/UNFCCC/status/1361355803949756416?ref_src=twsrc%5Etfw">February 15, 2021</a>
</blockquote>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mspaq7">
Scientists are still trying to sort out how jet streams have changed over time, and they don’t all agree on whether <a href="https://www.vox.com/climate">climate change</a> is playing a role. “That’s the million-dollar question,” White said. “My perspective is that there isn’t a strong scientific consensus.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lmwaXG">
<a href="https://www.sciencedirect.com/science/article/abs/pii/B9780128215753000153">One proposed mechanism</a> is that the Arctic is warming up to <a href="https://www.nature.com/articles/s43247-022-00498-3">four times as fast</a> as the rest of the planet, and as the temperature gradient between the North Pole and regions farther south gets shallower, the polar jet stream gets wavier. But the ordinary chaos of weather can also induce these waves, and since much of our understanding of jet streams is drawn from satellites, there isn’t a very long record of historical observations with which to compare. “The jury is still out on that, I think,” Seman said.
</p>
<h3 id="vpuOHj">
Warm waters means hot, sticky air
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hll32H">
One of the other remarkable aspects of the heat wave across the South is the high humidity. Meteorologists track the combination of heat and humidity with the <a href="https://www.weather.gov/ama/heatindex">heat index</a>, which reflects how the weather feels on the human body and how difficult it is to cool off by sweating. When the heat index gets too high, the weather can quickly become dangerous to many people.
</p>
<figure class="e-image">
<img alt="Chart showing heat index values. " src="https://cdn.vox-cdn.com/thumbor/p_Q_nK2WDuUrYDCRw4pvhu38kDY=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24763969/heatindexchart_650.jpeg"/> <cite><a class="ql-link" href="https://www.weather.gov/ama/heatindex" target="_blank">NOAA</a></cite>
<figcaption>
The combination of heat and humidity can quickly turn dangerous.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nMEiSP">
Gulf Coasters are of course well acquainted with humidity, but there are factors making the current damp spell unusual as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L53xvE">
The <a href="https://www.vox.com/climate/23762529/atlantic-ocean-record-heat-wave-el-nino-hurricane-climate-change">Atlantic Ocean</a> is seeing record-high temperatures this year, helping heat up water in the Gulf of Mexico. And since the 1970s, the gulf has been <a href="https://www.ncei.noaa.gov/news/gulf-mexico-getting-warmer">warming about twice as fast</a> as the rest of the world’s oceans. Hot water holds on to less oxygen, which can suffocate fish. High temperatures in the Gulf of Mexico have already been blamed for a fish kill in <a href="https://www.nytimes.com/2023/06/11/us/dead-fish-texas-climate-change.html">Texas</a> this year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xstrG5">
Hotter water also evaporates more readily. “​​That ‘pump’ off the Gulf of Mexico is becoming even stronger, raising the humidity levels,” Keim said. “By virtue of that, our heat index values … go up to 113 [degrees Fahrenheit]. We’re getting into a very dangerous range.”
</p>
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Further inland, the hot air is drawing water out of soil and vegetation. “We’re already seeing some crops starting to wilt from the heat and lack of moisture,” said Nielsen-Gammon.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SAz929">
The heat wave isn’t just manifesting at the upper end of the temperature range; it’s also <a href="https://www.nbcnews.com/science/environment/extreme-heat-texas-night-impacts-health-rcna91740">pushing up minimum temperatures</a> so that it stays warm overnight and into the early morning. When temperatures linger into the <a href="https://www.nytimes.com/2023/06/28/us/heat-wave-temperatures-forecast.html">90s after the sun sets</a>, people get little relief from the heat. It can disrupt sleep patterns and worsen underlying health problems.
</p>
<div id="qBwRVk">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Y’all, we just need to make it through the next day or 2 &amp; then it’ll be a little less oppressive. But today it’s still dangerously hot. Here’s a look at the heat index values as of 10:15am CDT.<br/><br/>Drink more water than you think you need &amp; take frequent breaks in the shade or A/C. <a href="https://t.co/bHx2gGFKCE">pic.twitter.com/bHx2gGFKCE</a>
</p>
— NWS New Orleans (<span class="citation" data-cites="NWSNewOrleans">@NWSNewOrleans</span>) <a href="https://twitter.com/NWSNewOrleans/status/1674802438661115908?ref_src=twsrc%5Etfw">June 30, 2023</a>
</blockquote>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nXrGCi">
“There may be more danger than a typical heat event, due to the longevity of near-record or record high nighttime lows and elevated heat index readings,” the National Weather Service’s <a href="https://www.nesdis.noaa.gov/news/extreme-heat-and-severe-weather-plague-parts-of-north-america">Weather Prediction Center</a> reported on Friday. <a href="https://www.vox.com/climate/2023/4/14/23677907/spring-summer-heat-climate-change-india-bangladesh-thailand">Heat waves that occur earlier in the season</a> tend to be more deadly because people are less acclimated to hot weather. Older adults, people with preexisting health problems, and people <a href="https://www.texastribune.org/2023/06/28/texas-prisons-heat-deaths/">without access to cooling, like those in prisons</a>, face especially high risks from high temperatures.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YRvhuc">
These effects are all further enhanced in dense cities like Houston and New Orleans where asphalt and concrete soak up the sun, creating <a href="https://www.epa.gov/heatislands">heat islands</a> that get hotter than their rural surroundings.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8HPO76">
On top of all this, the climate is changing. Average temperatures are rising, increasing the <a href="https://www.ipcc.ch/2021/08/09/ar6-wg1-20210809-pr/">likelihood and severity of heat waves</a> in much of the world. “Climate change looms large and hangs over all of this,” Keim said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1XXeye">
The heat wave across the South may break over the next week, but it is setting the stage for even more scorching weather. The current heat wave “will probably further increase the chances of hot temperatures because it’s accelerated the normal drying out of soils that takes place across Texas during June, July and August,” Nielsen-Gammon said. So drink plenty of water, stay in the shade, and take frequent breaks as you brace for the heat that lies ahead.
</p>
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<ul>
<li><strong>Why the media too often ignores the connection between climate change and meat</strong> -
<figure>
<img alt="Aerial view of many cows inside outdoor confinement pens" src="https://cdn.vox-cdn.com/thumbor/fMJcrdFNZNDZl6TPpvPUxAunJF4=/90x0:3646x2667/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72418544/957346812.0.jpg"/>
<figcaption>
<br/> | Getty
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The burger-sized hole in climate change coverage, explained.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6UrWbo">
Last weekend, <a href="https://www.vox.com/elon-musk">Elon Musk</a> posted one of his more <a href="https://twitter.com/elonmusk/status/1672793968587702272">outrageously false</a> tweets to date: “Important to note that what happens on Earth’s surface (eg farming) has no meaningful impact on <a href="https://www.vox.com/climate">climate change</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zChmEP">
Musk was, as he has been from <a href="https://www.theatlantic.com/technology/archive/2022/11/elon-musk-twitter-takeover-tweets/672040/">time to time</a>, wrong. As <a href="https://twitter.com/waiterich/status/1672904647093174272">climate</a> <a href="https://twitter.com/GlobalEcoGuy/status/1673142666983251968">experts</a> rushed to emphasize, farming actually accounts for around a quarter of global greenhouse gas emissions.<a href="https://www.epa.gov/ghgemissions/global-greenhouse-gas-emissions-data"></a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U6QjzG">
Before you add this to your list of criticisms of Musk, know that if you’re anything like the average person — or Musk himself — you too probably underestimate just how much agriculture, especially meat and dairy production, contributes to climate change and other environmental problems.
</p>
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Late last year, Madre Brava, an environmental research and advocacy group, commissioned a <a href="https://madrebrava.org/media/pages/insight/people-don-t-see-industrial-meat-as-a-key-cause-of-global-warming-poll/f945535138-1678895057/madre-brava_industrial-meat-production_northstar-public-survey_version-for-publication-media.pdf">poll</a> of 7,500 consumers across the US, the United Kingdom, Germany, France, and Brazil, asking which industries and environmental issues they thought were the biggest contributors to global warming. People generally ranked industrial meat production as one of the smallest contributors, even though it’s <a href="https://www.epa.gov/ghgemissions/global-greenhouse-gas-emissions-data">one of the largest</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yBGZF5">
The <a href="https://blog.humanesociety.org/2023/06/more-animals-than-ever-before-92-2-billion-are-used-and-killed-each-year-for-food.html">tens of billions</a> of chickens, pigs, cows, and other animals we raise and slaughter for food annually account for <a href="https://www.vox.com/future-perfect/23738600/un-fao-meat-dairy-livestock-emissions-methane-climate-change">around 15 percent</a> of global greenhouse gas emissions, primarily from cow burps, animal manure, and the fertilizer used to grow the corn and soy they eat. More than <a href="https://ourworldindata.org/global-land-for-agriculture">one-third</a> of the Earth’s habitable land is used for animal farming — much of it <a href="https://ourworldindata.org/drivers-of-deforestation">cleared</a> for cattle grazing and growing all that<strong> </strong>corn and soy — making animal agriculture the leading cause of <a href="https://ourworldindata.org/drivers-of-deforestation">deforestation</a> and <a href="https://www.vox.com/future-perfect/22287498/meat-wildlife-biodiversity-species-plantbased">biodiversity loss</a> globally. <a href="https://www.nytimes.com/2022/12/15/opinion/food-diets-meat-biodiverstiy-cop15.html"></a>
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Deforestation causes emissions itself, but it also represents a missed opportunity to sequester carbon. If that land were “rewilded,” or retired as farmland, it would act as a carbon sink, sucking <a href="https://www.nature.com/articles/s41586-018-0757-z">massive amounts</a> of climate-warming carbon out of the atmosphere. But we keep clearing <a href="https://www.vox.com/down-to-earth/23766056/deforestation-amazon-rainforest-palm-oil-cattle">more and more forestland</a>, especially in the Amazon rainforest and elsewhere in the tropics, mostly for beef, pork, and poultry.
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<figure class="e-image">
<img alt="Breakdown of how the world’s habitable land use has shifted over the last 5,000 years. Native forests and grasslands have declined significantly to make way for agriculture, the vast majority of which is taken up by animal agriculture." src="https://cdn.vox-cdn.com/thumbor/aXWOwWDAAUCC4l0IVnHhpdPKF2E=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24760732/Screen_Shot_2023_06_29_at_10.19.46_AM.png"/>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RjqFvB">
The consumer survey findings are bleak, and one major reason for them could be the fault of my own industry: journalism.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cfcQzc">
Madre Brava also conducted a <a href="https://madrebrava.org/media/pages/insight/people-don-t-see-industrial-meat-as-a-key-cause-of-global-warming-poll/e502b3de61-1678981785/meat-and-climate-media-coverage-analysis_madre-brava_16-march.pdf">media analysis</a> that found that between 2020 and 2022, less than 0.5 percent of stories about climate change by leading news outlets in the US, the United Kingdom, and Europe mentioned meat or livestock.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X74Vk5">
Last month, two groups that work on issues related to animal agriculture — Sentient Media and Faunalytics — published an <a href="https://osf.io/q4evn">analysis</a> with similar findings. The organizations looked at the 100 most recent climate change stories from each of the top 10 US media outlets, including the New York Times, the Washington Post, the Wall Street Journal, and CNN, and found that 7 percent mentioned animal agriculture. Of that 7 percent, most only discussed how climate change-fueled weather events like droughts, floods, and heatwaves impact animal farmers. “Across the 1,000 articles we examined, only a handful of stories reported in depth on the connection between consuming animal products and climate change,” the researchers wrote.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tNitgk">
The media is an easy target, and some criticism is deserved — it’s a disservice to readers to largely ignore a leading cause of the climate crisis. Part of the problem is that the media, like everyone else, operates in an information environment in which the meat lobby downplays and in some cases suppresses the full extent to which burgers, ribs, and chicken nuggets pollute the planet. But journalists could be doing more to cut through the noise.
</p>
<h3 id="lSikh9">
The food misinformation environment that reporters swim in
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ltAJyu">
Estimates vary, but peer-reviewed research says that animal agriculture causes between <a href="https://thebreakthrough.org/issues/food-agriculture-environment/livestock-dont-contribute-14-5-of-global-greenhouse-gas-emissions">15 percent to 19.6 percent</a> of climate-warming emissions. The United Nations’ most recent estimate puts animal agriculture’s emissions at 11.1 percent, but it hasn’t been peer-reviewed and has been <a href="https://www.vox.com/future-perfect/23738600/un-fao-meat-dairy-livestock-emissions-methane-climate-change">questioned</a> by some food and climate researchers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AM6rgt">
Last month, journalist Sophie Kevany <a href="https://www.vox.com/future-perfect/23738600/un-fao-meat-dairy-livestock-emissions-methane-climate-change">explained in detail for Vox</a> why there’s such a wide range in estimates, but here’s the gist: It’s hard to measure emissions from farms, there’s evidence these emissions are <a href="https://iopscience.iop.org/article/10.1088/1748-9326/ac02ef">undercounted</a>, and different models use different carbon accounting methods.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2PvNeb">
The range of estimates has left room for meat lobbyists to muddy the waters, creating an environment of misinformation and exaggeration.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rwdUIW">
For example, in recent years the beef industry has promoted a misleading method of counting the warming impact of methane, a highly potent greenhouse gas emitted by cows. “It’s the [beef] industry choosing metrics which make their impact look small,” Drew Shindell, a professor of Earth science at Duke University, <a href="https://www.bloomberg.com/news/features/2021-10-19/beef-industry-falsely-claims-low-cow-carbon-footprint">told Bloomberg</a> about the industry’s alternative math. “It’s not a credible way to approach the problem.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YjYG6q">
The National Cattlemen’s Beef Association, the industry’s leading lobby group, runs a “climate messaging machine,” food journalist Joe Fassler recently <a href="https://www.theguardian.com/environment/2023/may/03/beef-industry-public-relations-messaging-machine">wrote</a> in the Guardian, that trains influencers to confuse the public and downplay beef’s emissions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ya6Pp9">
The list goes on. Last year, leaked documents showed that delegates from Brazil and Argentina <a href="https://qz.com/ipcc-report-on-climate-change-meat-industry-1850261179">successfully lobbied</a> the United Nations’ Intergovernmental Panel on Climate Change to remove any mention of meat’s negative impact on the environment, or recommendations for people in rich countries to reduce their meat consumption, in its recent report. Meat giant Tyson Foods spends a much bigger share of its revenue than ExxonMobil lobbying Congress to <a href="https://www.vox.com/future-perfect/22379909/big-meat-companies-spend-millions-lobbying-climate">stop climate policy</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dY1Mxb">
Outside the <a href="https://www.vox.com/animal-welfare">animal rights</a> movement, there aren’t many voices pushing back against these narratives. The US environmental movement has largely <a href="https://www.forbes.com/sites/briankateman/2019/09/18/why-some-environmentalists-still-fail-to-promote-meat-reduction-as-an-answer-to-the-climate-crisis/?sh=483aa4be6453">shied away</a> from campaigning to reduce meat and dairy production, with some leaders <a href="https://newrepublic.com/article/159153/climate-change-dismiss-meat-emissions-wrong">outright rejecting</a> the notion that we need to eat fewer animals. Policymakers <a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1021013/full">largely avoid</a> the issue too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nQa6DF">
It’s no wonder that public health researchers, in a <a href="https://www.mdpi.com/2071-1050/14/19/12083">paper</a> published last year in the journal <em>Sustainability</em>, found that the media often engages in “both-sidesism” on meat’s role in climate change, treating it as more of an open debate than it really is.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4jcwnz">
There’s also a human element at play. Food is a touchy subject, and telling people to change what they eat can turn some readers hostile. “Ask me how I know,” said Tamar Haspel, a food and agriculture columnist for the Washington Post who regularly encourages people to eat less beef and more lentils, during a recent Sentient Media panel discussion.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G5A3yA">
A <a href="https://www.sciencedirect.com/science/article/abs/pii/S095937801400140X">2014 study</a> of US, Canadian, and Swedish environmental activists found a prevailing sentiment that climate groups felt influencing meat production wasn’t a part of their core mission and that changing diets has limited social and political appeal. That last part is true — people love to eat meat. But it’s on journalists and environmentalists to be clear-eyed about the realities of the climate crisis, and cover ideas — changing diets, yes, but also government food policy and farming practices and technologies — to try and get us out of it.
</p>
<h3 id="xqmu9E">
Improving how we talk about meat and climate change
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3z4mrp">
Given recent newsroom closures and mass reporter layoffs, news outlets aren’t likely to be hiring scores of reporters specializing in agriculture and the environment anytime soon. But there is something any newsroom can do: treat agriculture and climate change with the same level of skepticism and nuance as any other issue. There are plenty of examples in recent memory in which journalists haven’t.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="26JKqc">
For example, President Joe Biden’s landmark climate legislation, the <a href="https://www.vox.com/2022/8/8/23296951/inflation-reduction-act-biden-democrats-climate-change">Inflation Reduction Act</a>, included $20 billion for “climate-smart” farming, but there’s <a href="https://newrepublic.com/article/167267/climate-farming-inflation-reduction-act">scant evidence</a> that the IRA’s agricultural initiatives will meaningfully reduce emissions, especially since they don’t touch <a href="https://www.vox.com/future-perfect/2022/8/13/23301768/inflation-reduction-act-agriculture-meat-dairy-farming-plant-based">emissions from livestock</a>. Despite the limits of the legislation, most mentions of the agriculture component of the law <a href="https://apnews.com/article/biden-science-health-us-department-of-agriculture-efdd10e289a23151d720f18865daef21">received</a> <a href="https://www.reuters.com/business/sustainable-business/us-climate-deal-has-money-evs-clean-energy-even-big-oil-2022-08-08/">little</a> <a href="https://www.washingtonpost.com/climate-solutions/2022/08/14/nature-climate-solutions-inflation-reduction-act/">to no</a> <a href="https://www.nytimes.com/interactive/2022/08/13/upshot/whats-in-the-democrats-climate-health-bill.html">scrutiny</a> in <a href="https://www.latimes.com/politics/story/2022-08-19/democrats-inflation-reduction-act-midterms">initial</a> news coverage.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Sm6G7C">
“The [meat] industry is something we should really remain skeptical of … It’s every bit as powerful as oil and tobacco before that,” said Georgina Gustin, a reporter at Inside Climate News, at the Sentient Media panel. “I think that if we give industry too much credit by kid-gloving our treatment of farmers, then we’re making a mistake as journalists.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DJKpCd">
Leading news outlets <a href="https://www.standard.co.uk/culture/books/david-wallace-wells-climate-change-interview-a4238901.html">have</a> <a href="https://www.wired.com/story/carbon-neutral-cows-algae/">exaggerated</a> the potential emissions savings from feeding cattle seaweed. Many headlines have framed “regenerative agriculture” — an approach to farming that aims, among other aspirations, to store carbon in the soil — as something that could “save the planet.” But its carbon-storing potential <a href="https://www.wri.org/insights/regenerative-agriculture-good-soil-health-limited-potential-mitigate-climate-change">remains</a> <a href="https://www.sierraclub.org/sierra/2022-2-summer/feature/dirt-first-carbon-farming-regenerative-agriculture">speculative</a>, and regenerative agriculture generally requires <a href="https://www.washingtonpost.com/food/2022/10/03/beef-soil-carbon-sequestration/">much</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831153/">more land</a> than conventional farming, an <a href="https://www.nature.com/articles/s41586-018-0757-z">environmental drawback</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c7JlmD">
Also, be skeptical of <a href="https://www.vox.com/future-of-meat">meat alternative</a> startups. <a href="https://www.vox.com/future-perfect/2022/9/12/23339898/global-meat-production-forecast-factory-farming-animal-welfare-human-progress">I think</a> developing better veggie burgers and nuggets is an important pursuit to cut food system emissions, but the field has been prone to hype. Most products are still <a href="https://www.vox.com/future-perfect/2023/4/17/23682232/impossible-beyond-plant-based-meat-sales">too expensive</a> and don’t <a href="https://www.vox.com/future-perfect/23065941/vegan-vegetarian-plant-based-food-tech-bad-products">taste good enough</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EjtUVi">
On top of applying healthy skepticism to claims made in the food and agriculture sphere, journalists could also be more specific by naming <em>animal</em> agriculture as the top cause for an environmental problem when appropriate, not agriculture writ large. For example, “agriculture” is sometimes cited as a major cause of the Colorado River water shortage, which could lead readers to think that the current sky-high levels of water use for agriculture in the Western US are just an inevitable part of feeding the world. But <a href="https://www.vox.com/the-highlight/23655640/colorado-river-water-alfalfa-dairy-beef-meat">at least 70 percent</a> of the water diverted from the Colorado River for agriculture is used to grow feed for beef and dairy cows, and animal products generally require <a href="https://ourworldindata.org/grapher/water-withdrawals-per-kg-poore">much more water</a> than plant-based foods.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="voULoO">
Covering this huge, complex issue with skepticism and nuance requires time, resources, and specialization, all luxuries many reporters don’t have. The problem is a symptom of bigger challenges in journalism.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jrNkac">
To be sure, in addition to journalists quoted in this article, there are a number of <a href="https://newrepublic.com/tags/meat-industry">news</a> <a href="https://www.theguardian.com/environment/series/animals-farmed">outlets</a>, non-profits, and <a href="https://www.jennysplitter.com/">writers</a> that <a href="https://www.andrewwasley.com/">regularly</a> <a href="https://muckrack.com/spencer-roberts/articles">report</a> on how <a href="https://civileats.com/">what we eat</a> contributes to <a href="https://www.desmog.com/">climate change</a>. But an enormous coverage gap remains. It may just take time for stakeholders in the climate crisis — journalists, policymakers, environmentalists, and consumers — to catch up.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J2IWlI">
“The food conversation is probably about 20 years behind the energy conversation, and it is catching up, but it’s not visceral to people in the way energy is — that they immediately know energy is a climate issue,” said Michael Grunwald, a food and agriculture columnist for Canary Media, in the Sentient Media panel discussion.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zeFdD9">
But time is in short supply. <a href="https://www.science.org/doi/10.1126/science.aba7357">Experts say</a> that if we don’t change what we eat — especially reducing beef and dairy — we can’t meet the Paris climate agreement of limiting global warming to 2 degrees Celsius or less. Journalists have risen to the occasion before: Coverage of climate change has <a href="https://sciencepolicy.colorado.edu/icecaps/research/media_coverage/summaries/special_issue_2022.html">increased</a> in recent decades, especially in the last few years. Hopefully reporting on the emissions from what we put on our plate will follow a similar trajectory.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Austrian GP 2023 | Verstappen sees off Leclerc for fourth pole in a row</strong> - The session proved a nightmare for Perez, who already 69 points behind Verstappen after eight races all won by Red Bull, had three laps deleted for exceeding track limits</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I am a cricket lover like every Indian, our work will silence murmurs about dynasty politics: Rohit Pawar</strong> - The Maharashtra Cricket Association president speaks about plans to better support former cricketers, expand the Maharashtra Premier League fanbase and radius, improve district cricket infrastructure, ensure fair treatment across men’s and women’s State teams, revenue sharing models, and BCCI support</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ladies Finnish Open | Diksha fights back to make cut in Finland alongside Pranavi</strong> - Needing a good solid second round after a birdie-less first round of 74, Diksha played a stunning 5-under for the front nine but dropped two bogeys against just one birdie on the back nine</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neeraj Chopra wins second straight Diamond League title in Lausanne</strong> - Coming back from a one-month injury lay-off, Chopra’s title-winning performance at the Lausanne leg in challenging conditions was below his own top-10 efforts but he still stamped his authority in the prestigious One-day meet</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Duleep Trophy 2023 | North Zone thrashes North East by 511 runs, storm into semifinals</strong> - Chasing a mammoth 666 to win, North East Zone were bundled out for 154 in their second innings; North will face Mayank Agarwal-led South Zone in semifinals</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>M.P. High Court requests Centre to reduce women’s consent age to 16 from 18</strong> - The court’s request came on June 27 through an order quashing a First Information Report (FIR) against a man who was accused of repeatedly raping a minor girl and impregnating her in 2020</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Right time to bring UCC, Opposition should refrain from communal politics: Naqvi</strong> - The mood of the nation is to make Uniform Civil Code free from the “clutches of communal conspirators” who held this hostage for the last seven decades</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Demonstrations held in Manipur demanding peaceful resolution to crisis</strong> - In Imphal East district and Jiribam district, women staged a sit-in.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Groundwater department to ramp up infrastructure for testing groundwater quality</strong> - As per a proposal cleared by the State government on June 27, the department will arrange more observation wells in regions where groundwater quality is a matter of concern.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>LiDAR survey soon to speed up trains in Thiruvananthapuram-Mangaluru corridor</strong> - DPR for third, fourth tracks on Ernakulam-Shornur stretch to be submitted to Railway Board by July-end</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>France shooting: Macron accuses rioters of exploiting teen killed by police</strong> - At a crisis meeting, France’s president condemns three nights of riots as “unjustifiable”.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>France riots: Nanterre rocked by killing and unrest</strong> - The town of Nanterre is shaken by nights of rioting after 17-year-old Nahel was shot by police.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Deciphering Vladimir Putin’s many appearances since mutiny</strong> - The Russian president has popped up on TV screens multiple times since last weekend’s dramatic events - but to what end?</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Moldova attack: Two dead as man opens fire inside Chisinau airport</strong> - The man was denied entry to Chisinau airport and then shot two officials, authorities say.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Greece boat disaster: Survivors blame Greek coastguard for tragedy</strong> - Survivors of the Greece boat disaster say an attempt by the Greek coastguard to tow the boat made it sink.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clever DNA tricks</strong> - As cells divide, they must copy all of their chromosomes only once or chaos will ensue. - <a href="https://arstechnica.com/?p=1951322">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Saturn’s rings steal the show in new image from Webb telescope</strong> - Webb turned its gold-coated mirror toward Saturn this week. - <a href="https://arstechnica.com/?p=1951436">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Death toll rises to 7 in fungal meningitis outbreak; cases at 34, 161 at risk</strong> - Anyone exposed should get medical care and testing immediately, even without symptoms. - <a href="https://arstechnica.com/?p=1951425">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Asus Zenfone 10 is a tiny 5.9-inch phone with flagship specs</strong> - Asus invites small phone lovers to put their money where their mouth is. - <a href="https://arstechnica.com/?p=1951351">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FBI finally tracks “swatting” incidents as attacks increase nationwide</strong> - Experts aren’t sure the database will reverse troubling swatting trend. - <a href="https://arstechnica.com/?p=1951389">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Forging A Return To Productive Conversation: An Open Letter to Reddit</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
To All Whom It May Concern,
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
For fifteen years, <a href="https://www.reddit.com/r/Jokes">/r/Jokes</a> has been one of Reddit’s most-popular communities. That time hasn’t been without its difficulties, but for the most part, we’ve all gotten along (with each other and with administrators). Members of our team fondly remember Moderator Roadshows, visits to Reddit’s headquarters, Reddit Secret Santa, April Fools’ Day events, regional meetups, and many more uplifting moments. We’ve watched this platform grow by leaps and bounds, and although we haven’t been completely happy about every change that we’ve witnessed, we’ve always done our best to work with Reddit at finding ways to adapt, compromise, and move forward.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
This process has occasionally been preceded by some exceptionally public debate, however.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
On June 12th, 2023, <a href="https://www.reddit.com/r/Jokes">/r/Jokes</a> joined thousands of other subreddits in protesting the planned changes to Reddit’s API; changes which – despite being immediately evident to only a minority of Redditors – threatened to worsen the site for everyone. By June 16th, 2023, that demonstration had evolved to represent a wider (and growing) array of concerns, many of which arose in response to <a href="https://www.washingtonpost.com/technology/2023/06/16/reddit-ceo-blackout-moderators-steve-huffman/">Reddit’s statements to journalists</a>. Today (June 26th, 2023), we are hopeful that users and administrators alike can make a return to the productive dialogue that has served us in the past.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
We acknowledge that Reddit has placed itself in a situation that makes adjusting its current API roadmap impossible.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
However, we have the following requests:
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Commit to exploring ways by which third-party applications can make an affordable return.
</li>
<li>
Commit to providing moderation tools and <a href="https://www.reddit.com/r/Blind/comments/14ds81l/rblinds_meetings_with_reddit_and_the_current/">accessibility options</a> (on Old Reddit, New Reddit, and mobile platforms) which match or exceed the functionality and utility of third-party applications.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Commit to prioritizing a significant reduction in spam, misinformation, bigotry, and illegal content on Reddit.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Guarantee that any future developments which may impact moderators, contributors, or stakeholders will be announced no less than one fiscal quarter before they are scheduled to go into effect.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Work together with longstanding moderators to establish a reasonable roadmap and deadline for accomplishing all of the above.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Affirm that efforts meant to keep Reddit accountable to its commitments and deadlines will hereafter not be met with insults, threats, removals, or hostility.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Publicly affirm all of the above by way of updating Reddit’s User Agreement and Reddit’s Moderator Code of Conduct to include reasonable expectations and requirements for administrators’ behavior.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Implement and fill a senior-level role (with decision-making and policy-shaping power) of “Moderator Advocate” at Reddit, with a required qualification for the position being robust experience as a volunteer Reddit moderator.
</li>
</ul>
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Reddit is unique amongst social-media sites in that its lifeblood – its multitude of moderators and contributors – consists entirely of volunteers. We populate and curate the platform’s many communities, thereby providing a welcoming and engaging environment for all of its visitors. We receive little in the way of thanks for these efforts, but we frequently endure abuse, threats, attacks, and exposure to truly reprehensible media. Historically, we have trusted that Reddit’s administrators have the best interests of the platform and its users (be they moderators, contributors, participants, or lurkers) at heart; that while Reddit may be a for-profit company, it nonetheless recognizes and appreciates the value that Redditors provide.
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That trust has been all but entirely eroded… but we hope that together, we can begin to rebuild it.
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In simplest terms, Reddit, we implore you: <strong>Remember the human</strong>.
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We look forward to your response by Thursday, June 29th, 2023.
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There’s also just <a href="https://i.imgur.com/xLmTxcR.jpg">one other thing</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/JokeSentinel"> /u/JokeSentinel </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14jn9rg/forging_a_return_to_productive_conversation_an/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14jn9rg/forging_a_return_to_productive_conversation_an/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>God: “Adam, I’ll let you name the birds”</strong> - <!-- SC_OFF --></p>
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Adam: “Tit”
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God: “Uhh ok”
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Adam: “Boobie”
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God: “Stop naming them after breasts”
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Adam: <em>Looks at rooster</em>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MudakMudakov"> /u/MudakMudakov </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14ng872/god_adam_ill_let_you_name_the_birds/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14ng872/god_adam_ill_let_you_name_the_birds/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Have you ever noticed how most Ford vehicles names are more fun when you put “anal” in front of them?</strong> - <!-- SC_OFF --></p>
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Probe, Explorer, Excursion, Endeavor, Ranger, Focus
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Sean_0510"> /u/Sean_0510 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14nrvqu/have_you_ever_noticed_how_most_ford_vehicles/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14nrvqu/have_you_ever_noticed_how_most_ford_vehicles/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A man was away on a business trip, and decided to call his wife and to let her know he had arrived safely</strong> - <!-- SC_OFF --></p>
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A little girl picks up the phone. “Hello?”
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“Hi, Honey. This is Daddy, is mommy near the phone?” Daddy asks
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“No, Daddy. She’s upstairs in the bedroom with uncle Paul.”
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After a brief pause, Daddy says “But, honey, you haven’t got an uncle Paul.”
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“Oh, yes I do, and he’s upstairs in the room with mommy, right now.”
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Dad takes a second to process this, then speaks. “Uh, ok, then this is what I want you to do. Put the phone down on the table, run upstairs, knock on the bedroom door and shout to mommy that daddy’s car just pulled into the driveway.”
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A few minutes later the little girl comes back to the phone. “I did it, daddy!”
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“And what happened, honey?” he asked
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“Well mommy got all scared, jumped out of bed with no clothes on and ran around screaming. Then she tripped over the rug, hit her head on the dresser and now she isn’t moving at all!”
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“Oh my god! what about uncle Paul?”
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“He jumped out of the bed with no clothes on, too. He was all scared and he jumped out of the back window and into the swimming pool. But I guess he didn’t knew that you took out the water last week to clean it. He hit the bottom of the pool and I think he’s dead.”
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<em>A long, silent pause</em>
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​
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Then Daddy says, “Swimming pool?……. Is this 418-6819?”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/castle_03"> /u/castle_03 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14nmpuf/a_man_was_away_on_a_business_trip_and_decided_to/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14nmpuf/a_man_was_away_on_a_business_trip_and_decided_to/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Two rednecks decided that they weren’t going anywhere in life</strong> - <!-- SC_OFF --></p>
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They thought they should go to college to get ahead. The first goes in to see the counselor, who tells him to take Math, History, and Logic. “What’s Logic?” the first redneck asks. The professor answers by saying, “Let me give you an example. Do you own a weedeater?” “I sure do.” “Then I can assume, using logic, that you have a yard,” replied the professor. “That’s real good!” says the redneck. The professor continues, “Logic will also tell me that since you have a yard, you also own a house.” Impressed, the redneck says, “Amazin!” “And since you own a house, logic dictates that you have a wife.” “That’s Betty Mae! This is incredible!” The redneck is obviously catching on. “Finally, since you have a wife, logically I can assume that you are heterosexual,” said the professor. “You’re absolutely right! Why that’s the most fascinatin’ thing I ever heard! I cain’t wait to take that logic class!!” The redneck, proud of the new world opening up to him, walks back into the hallway, where his friend is still waiting. “So what classes are ya takin’?” asks the friend. “Math, History, and Logic!” replies the first redneck. “What in tarnation is logic???” asked his friend. “Let me give you an example. Do ya own a weedeater?” asked the first redneck. “No,” his friend replied. “SO YOU LIKE GUYS, Don t Ya ?”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/kickypie"> /u/kickypie </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14ngnfz/two_rednecks_decided_that_they_werent_going/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14ngnfz/two_rednecks_decided_that_they_werent_going/">[comments]</a></span></p></li>
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