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<title>12 November, 2023</title>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Covid19Vaxplorer: a free, online, user-friendly COVID-19 Vaccine Allocation Comparison Tool</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: There are many COVID-19 vaccines currently available, however, Low- and middle-income countries (LMIC) still have large proportions of their populations un- vaccinated. Decision-makers must decide how to effectively allocate available vaccines (e.g. boosters or primary series vaccination, which age groups to target) but LMIC often lack the resources to undergo quantitative analyses of vaccine allocation, resulting in ad- hoc policies. We developed Covid19Vaxplorer (https://covid19vaxplorer.fredhutch.org/), a free, user-friendly online tool that simulates region-specific COVID-19 epidemics in con- junction with vaccination with the purpose of providing public health officials worldwide with a tool for vaccine allocation planning and comparison. Methods: We developed an age-structured mathematical model of SARS-CoV-2 trans- mission and COVID-19 vaccination. The model considers vaccination with up to three different vaccine products, primary series and boosters. We simulated partial immunity de- rived from waning of natural infection and vaccination. The model is embedded in an online tool, Covid19Vaxplorer that was optimized for its ease of use. By prompting users to fill information through several windows to input local parameters (e.g. cumulative and cur- rent prevalence), epidemiological parameters (e.g basic reproduction number, current social distancing interventions), vaccine parameters (e.g. vaccine efficacy, duration of immunity) and vaccine allocation (both by age groups and by vaccination status). Covid19Vaxplorer connects the user to the mathematical model and simulates, in real time, region-specific epidemics. The tool then produces key outcomes including expected numbers of deaths, hospitalizations and cases, with the possibility of simulating several scenarios of vaccine allocation at once for a side-by-side comparison.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.15.23291472v2" target="_blank">Covid19Vaxplorer: a free, online, user-friendly COVID-19 Vaccine Allocation Comparison Tool</a>
</div></li>
<li><strong>Prosocial behavior in emergencies: Evidence from blood donors recruitment and retention during the COVID-19 pandemic</strong> -
<div>
The impact of COVID-19 represents a specific challenge for voluntary transfusional systems sustained by the intrinsic motivations of blood donors. In general, health emergencies can stimulate altruistic behaviors. However, in this context, the same prosocial motivations, besides the personal health risks, could foster the adherence to social distancing rules to preserve collective health and, therefore, discourage blood donation activities. In this work, we investigate the consequences of the pandemic shock on the dynamics of new donors exploiting the individual-level longitudinal information contained in administrative data on the Italian region of Tuscany. We compare the change in new donors’ recruitment and retention during 2020 with respect to the 2017-2019 period, considering donors’ and their municipalities of residence characteristics. Our results show an increment of new donors, with higher growth for older donors. Moreover, we demonstrate that the quality of new donors, as proxied by the frequency of subsequent donations, increased with respect to previous years. Finally, we show that changes in extrinsic motivations, such as the possibility of obtaining a free antibody test or overcoming movement restrictions, cannot explain the documented improvement in performances.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/psyarxiv/6t72b/" target="_blank">Prosocial behavior in emergencies: Evidence from blood donors recruitment and retention during the COVID-19 pandemic</a>
</div></li>
<li><strong>Clinical and Economic impact of updated Fall 2023 COVID-19 vaccines in the Immunocompromised Population in Canada</strong> -
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Background: Immunocompromised (IC) individuals are at increased risk of COVID-19 infection-related severe outcomes. Moderna and Pfizer-BioNTech COVID-19 mRNA vaccines are available in Canada, and differences in vaccine effectiveness (VE) have been found between the two in IC individuals. The objective of this analysis was to compare the clinical and economic impact of a Moderna XBB.1.5 updated COVID-19 mRNA Fall 2023 vaccine to a Pfizer-BioNTech XBB.1.5 updated COVID-19 mRNA Fall 2023 vaccine in Canadian IC individuals aged ≥18 years. Methods: A static decision-analytic model estimated the number of COVID-19 infections, hospitalizations, deaths, and resulting quality-adjusted life years (QALYs) over a one-year time horizon (September 2023-August 2024) in the Canadian IC adult population (n=894,580). Costs associated with COVID-19 infection were estimated from health care and societal perspectives. The predicted VE of the updated Moderna vaccine was based on prior variant versions, which were well-matched to the circulating variant. Pfizer-BioNTech VE was calculated based on a meta-analysis of comparative effectiveness between both vaccines (relative risk for Moderna vaccine: infection=0.85 [95%CI 0.75-0.97], hospitalization=0.88 [95%CI 0.79-0.97]). The model combined VE estimates with COVID-19 incidence and probability of COVID-19 related severe outcomes. Sensitivity analyses tested the impact of uncertainty surrounding incidence, hospitalization and mortality rates, costs, and QALYs. Results: Given the expected higher VE against infection and hospitalizations with the Moderna Fall 2023 vaccine, its use is predicted to prevent an additional 2,411 infections (3.6%), 275 hospitalizations (3.7%), and 47 deaths (4.0%) compared to the Pfizer-BioNTech Fall 2023 vaccine, resulting in 330 QALYs gained, and savings of $7.4M in infection treatment costs, and $0.9M in productivity loss costs. Results were most sensitive to variations in VE parameters, specifically the relative risk of infection and hospitalizations between the vaccines, and waning rates. Conclusions: If the Moderna and Pfizer-BioNTech Fall 2023 vaccines protect against infection and hospitalizations similar to previous vaccines, using the Moderna Fall 2023 vaccine would result in substantial public health benefits in IC individuals, as well as provide health care and societal cost savings.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.11.10.23298369v1" target="_blank">Clinical and Economic impact of updated Fall 2023 COVID-19 vaccines in the Immunocompromised Population in Canada</a>
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<li><strong>Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment</strong> -
<div>
The Coronavirus disease 2019 (COVID19) pandemic caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is an ongoing threat to global public health. To this end, intense efforts are underway to develop reagents to aid in diagnostics, enhance preventative measures, and provide therapeutics for managing COVID-19. The recent emergence of SARS-CoV-2 Omicron variants with enhanced transmissibility, altered antigenicity, and significant escape of existing monoclonal antibodies and vaccines underlines the importance of the continued development of such agents. The SARS-CoV-2 spike protein and its receptor binding domain (RBD) are critical to viral attachment and host cell entry and are primary targets for antibodies elicited from both vaccination and natural infection. In this study, mice were immunized with two synthetic peptides (Pep 1 and Pep 2) within the RBD of the original Wuhan SARS-CoV-2, as well as the whole RBD as a recombinant protein (rRBD). Hybridomas were generated and a panel of three monoclonal antibodies, mAb CU-P1-1 against Pep 1, mAb CU-P2-20 against Pep 2, and mAb CU-28-24 against rRBD, were generated and further characterized. The monoclonal antibodies were shown through ELISA to be specific for each immunogen/antigen and to be reactive by immunoblotting against RBD. Monoclonal antibody CU-P1-1 has limited applicability other than in ELISA approaches and basic immunoblotting. Monoclonal antibody CU-P2-20 is shown to be favorable for ELISA, immunoblotting, and immunohistochemistry (IHC), however, not live virus neutralization. In contrast, mAb CU-28-24 is most effective at live virus neutralization as well as ELISA, immunoblotting, and IHC. Moreover, mAb CU-28-24 was active against rRBD proteins from Omicron variants B.2 and B.4/B5 as determined by ELISA, suggesting this mAb may neutralize live virus of these variants. Each of the immunoglobulin genes has been sequenced using Next Generation Sequencing, which allows the expression of respective recombinant proteins, thereby eliminating the need for long-term hybridoma maintenance. These hybridomas and related mAbs are now protected by Intellectual Property agreements with the Clemson University Research Foundation and are Patent Pending based on their unique amino acids within the complementary determining regions (CDRs).
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.11.08.566276v1" target="_blank">Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment</a>
</div></li>
<li><strong>The influence of COVID-19 fear beliefs on the relationships between positive mood and loss-of-control eating: a ten-day diary study</strong> -
<div>
Objectives: Loss-of-control eating (LOCE), a perceived inability to stop eating or to resist eating onset, is driven by mood. LOCE prevalence increased following onset of coronavirus 2019 (COVID-19). COVID-19 has been associated with significant increase in stressors, such as fear beliefs regarding contracting illness. Fear beliefs could in turn impact a relationship between mood and LOCE. It was also hypothesized that daily protective strategies meant to prevent contagion may be associated with LOCE, in line with ego depletion theory. Design: This was a two-phase study with a cross-sectional phase and daily diary design. Methods: 108 adults from the United States completed a diary study over ten days regarding daily LOCE, positive and negative mood, and protective behaviors against contagion. Participants rated COVID-fear beliefs at a baseline assessment, hypothesized to predict LOCE directly between subjects and have a cross-level interactive effect on predictors within-subjects. Data were analyzed both within- and between-subjects with a multilevel model. Results: Negative mood was associated with LOCE at both levels, although protective behaviors evinced no significant associations. Positive mood did not reveal significant direct associations with LOCE, although there was an interactive effect such that positive mood was a significant model predictor at low COVID fear beliefs. Johnson-Neyman analyses showed that when COVID-fear beliefs were low, positive mood had a significant inverse association with LOCE. Conclusion: Negative mood and protective strategies are directly associated with LOCE but the relationship between positive mood and LOCE may be moderated by the degree of COVID-19 fear beliefs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/psyarxiv/ta659/" target="_blank">The influence of COVID-19 fear beliefs on the relationships between positive mood and loss-of-control eating: a ten-day diary study</a>
</div></li>
<li><strong>A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases</strong> -
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Abstract Introduction: The aim of this study was to assess the possible extent of bias due to violation of a core assumption (event-dependent exposures) when using self-controlled designs to analyse the association between COVID-19 vaccines and myocarditis. Methods: We used data from five European databases (Spain: BIFAP, FISABIO VID, and SIDIAP; Italy: ARS-Tuscany; England: CPRD Aurum) converted to the ConcePTION Common Data Model. Individuals who experienced both myocarditis and were vaccinated against COVID-19 between 1 September 2020 and the end of data availability in each country were included. We compared a self-controlled risk interval study (SCRI) using a pre-vaccination control window, an SCRI using a post-vaccination control window, a standard SCCS and an extension of the SCCS designed to handle violations of the assumption of event-dependent exposures. Results: We included 1,757 cases of myocarditis. In unadjusted analyses, agreement between study designs varied by vaccine brand. There was good agreement between all designs for AstraZeneca and Pfizer, but for Moderna we found harmful incidence rate ratios (IRR) using the standard and extended SCCS (standard SCCS: IRR = 3.12, 95%CI = 1.53, 6.40; extended SCCS: IRR = 2.43, 95%CI = 1.11, 5.33) compared with no association with the SCRIs (SCRI-pre: IRR = 0.60, 95%CI = 0.27, 1.33; SCRI-post: IRR = 0.86, 95%CI = 0.34, 2.19), although confidence intervals were wide. There was very good agreement between all designs for the unadjusted second dose analyses, confirming the known harmful association between the second dose of Moderna and Pfizer vaccines and myocarditis. Conclusions: In the context of the known association between COVID-19 vaccines and myocarditis, we have demonstrated that two forms of SCRI and two forms of SCCS led to largely comparable results, possibly because of limited violation of the assumption of event-dependent exposures.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.11.10.23298290v1" target="_blank">A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases</a>
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<li><strong>Collateral effects of the COVID-19 pandemic on endocrine treatments for breast and prostate cancer in the UK: implications for bone health</strong> -
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Background: The COVID-19 pandemic affected cancer screening, diagnosis and treatment pathways. This study examined the impact of the pandemic on incidence and trends of endocrine treatments in patients with breast or prostate cancer; and endocrine treatment-related side-effects. Methods: Population-based cohort study using UK primary care Clinical Practice Research Datalink (CPRD) GOLD database. There were 13,701 newly diagnosed breast cancer patients and 12,221 prostate cancer patients with ≥1-year data availability since diagnosis between January 2017-June 2022. Incidence rates (IR) and incidence rate ratios (IRR) were calculated across multiple time periods before and after lockdown to examine the impact of changing social restrictions on endocrine treatments and treatment-related outcomes, including osteopenia, osteoporosis and bisphosphonate prescriptions. Results: In patients with breast cancer, aromatase inhibitor prescriptions increased during lockdown compared to pre-pandemic (IRR: 1.22 [95% Confidence Interval: 1.11-1.34]), followed by a decrease post-first lockdown (IRR: 0.79 [95%CI: 0.69-0.89]). In patients with prostate cancer, first-generation antiandrogen prescriptions increased compared to pre-pandemic (IRR: 1.23 [95% CI: 1.08-1.4]). For breast cancer patients on aromatase inhibitors, diagnoses of osteopenia, osteoporosis and bisphosphonate prescriptions were reduced across all lockdown periods compared to pre-pandemic (IRR range: 0.31-0.62). Conclusion: During the first two years of the pandemic, newly diagnosed breast and prostate cancer patients were prescribed more endocrine treatments compared to pre-pandemic, due to restrictions on hospital procedures replacing surgeries with bridging therapies. But breast cancer patients had fewer diagnoses of osteopenia and osteoporosis, and bisphosphonate prescriptions. These patients should be followed up in the coming years for signs of bone thinning. Evidence of poorer management of treatment-related side-effects will allow us to determine whether there is a need to better allocate resources to patients at high risk for bone-related complications.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.11.09.23298305v1" target="_blank">Collateral effects of the COVID-19 pandemic on endocrine treatments for breast and prostate cancer in the UK: implications for bone health</a>
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<li><strong>Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization</strong> -
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Introduction: A chronic post-vaccination syndrome (PVS) after covid-19 vaccination has been reported but has yet to be well characterized. Methods: We included 241 individuals aged 18 and older who self-reported PVS after covid-19 vaccination and who joined the online Yale Listen to Immune, Symptom and Treatment Experiences Now (LISTEN) Study from May 2022 to July 2023. We summarized their demographics, health status, symptoms, treatments tried, and overall experience. Results: The median age of participants was 46 years (interquartile range [IQR]: 38 to 56), with 192 (80%) identifying as female, 209 (87%) as non-Hispanic White, and 211 (88%) from the United States. Among these participants with PVS, 127 (55%) had received the BNT162b2 [Pfizer-BioNTech] vaccine, and 86 (37%) received the mRNA-1273 [Moderna] vaccine. The median time from the day of index vaccination to symptom onset was three days (IQR: 1 day to 8 days). The time from vaccination to symptom survey completion was 595 days (IQR: 417 to 661 days). The median Euro-QoL visual analogue scale score was 50 (IQR: 39 to 70). The five most common symptoms were exercise intolerance (71%), excessive fatigue (69%), numbness (63%), brain fog (63%), and neuropathy (63%). In the week before survey completion, participants reported feeling unease (93%), fearfulness (82%), and overwhelmed by worries (81%), as well as feelings of helplessness (80%), anxiety (76%), depression (76%), hopelessness (72%), and worthlessness (49%) at least once. Participants reported a median of 20 (IQR: 13 to 30) interventions to treat their condition. Conclusions: In this study, individuals who reported PVS after covid-19 vaccination had low health status, high symptom burden, and high psychosocial stress despite trying many treatments. There is a need for continued investigation to understand and treat this condition.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.11.09.23298266v1" target="_blank">Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization</a>
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<li><strong>One year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study</strong> -
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Background In patients with COVID-19 requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute COVID-19 would be associated with improved health-related quality of life (HRQoL) one year after discharge. Methods Adults admitted to hospital between February 2020 and March 2021 for COVID-19 and meeting current guideline recommendations for dexamethasone treatment were included using two prospective UK cohort studies. HRQoL, assessed by EQ-5D-5L utility index, pre-hospital and one year after discharge were compared between those receiving corticosteroids or not after propensity weighting for treatment. Secondary outcomes included patient reported recovery, physical and mental health status, and measures of organ impairment. Sensitivity analyses were undertaken to account for survival and selection bias. Findings In 1,888 participants included in the primary analysis, 1,149 received corticosteroids. There was no between-group difference in EQ-5D-5L utility index at one year (mean difference 0.004, 95% CI: -0.026 to 0.034, p = 0.77). A similar reduction in EQ-5D-5L was seen at one year between corticosteroid exposed and non-exposed groups (mean (SD) change -0.12 (0.22) vs -0.11 (0.22), p = 0.32). Overall, there were no differences in secondary outcome measures. After sensitivity analyses modelled using a larger cohort of 109,318 patients admitted to hospital with COVID-19, EQ-5D-5L utility index at one year remained similar between the two groups. Interpretation Systemic corticosteroids for acute COVID-19 have no impact on the large reduction in HRQoL one year after hospital discharge. Treatments to address this are urgently needed.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.11.09.23298162v1" target="_blank">One year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study</a>
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<li><strong>Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5</strong> -
<div>
Antibodies play a central role in the immune defense against SARS-CoV-2. Strong evidence has shown that non-neutralizing antibodies (nnAbs) are important for anti-SARS-Cov-2 immunity through Fc-mediated effector functions. These nnAbs bind to epitopes that could be less subjected to mutations in the emerging variants. When protective, such nnAbs would constitute a more promising alternative to neutralizing mAbs (nAbs). Here, we show that six nnAbs retain binding to Omicron, while two nAbs do not. Furthermore, two of our nnAbs, which are protective in vivo, retained binding to XBB, XBB.1.5, and BQ.1.1. They appear to bind to conserved epitopes on the N-terminal and receptor binding domain (RBD), respectively. As a proof of concept, we show that these protective non-neutralizing antibodies retain potent Fc-mediated opsonic function against BQ.1.1 and XBB. We also show that the Fc-mediated function is further enhanced by expressing the antibodies in the IgG3 subclass and combining them into a dual antibody cocktail. Our work suggests that opsonizing nnAbs could be a viable strategy for anti-SARS-CoV-2 mAb therapies against current and future SARS-CoV-2 variants.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.29.560084v2" target="_blank">Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5</a>
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<li><strong>Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19</strong> -
<div>
The long-term health effects of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are quickly evolving into a major public health concern, but the underlying cellular and molecular etiology remain poorly defined. There is growing evidence that PASC is linked to abnormal immune responses and/or poor organ recovery post-infection. However, the exact processes linking non-resolving inflammation, impaired tissue repair, and PASC are still unclear. In this report, we utilized a cohort of respiratory PASC patients with viral infection-mediated pulmonary fibrosis and a clinically relevant mouse model of post-viral lung sequelae to investigate the pathophysiology of respiratory PASC. Using a combination of imaging and spatial transcriptomics, we identified dysregulated proximal interactions between immune cells and epithelial progenitors unique to respiratory PASC but not acute COVID-19 or idiopathic pulmonary fibrosis (IPF). Specifically, we found a central role for lung-resident CD8+ T cell-macrophage interactions in maintaining Krt8hi transitional and ectopic Krt5+ basal cell progenitors, and the development of fibrotic sequelae after acute viral pneumonia. Mechanistically, CD8+ T cell derived IFN-{gamma} and TNF stimulated lung macrophages to chronically release IL-1{beta}, resulting in the abnormal accumulation of dysplastic epithelial progenitors in fibrotic areas. Notably, therapeutic neutralization of IFN-{gamma} and TNF, or IL-1{beta} after the resolution of acute infection resulted in markedly improved alveolar regeneration and restoration of pulmonary function. Together, our findings implicate a dysregulated immune-epithelial progenitor niche in driving respiratory PASC and identify potential therapeutic targets to dampen chronic pulmonary sequelae post respiratory viral infections including SARS-CoV-2.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.13.557622v2" target="_blank">Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19</a>
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<li><strong>Occupational resilience factors among healthcare workers during the COVID-19 pandemic: a 2-year prospective cohort study</strong> -
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Background. Healthcare workers (HCWs) in COVID-19 pandemic hotspots were exposed to workplace stressors. Structural occupational factors that prevent stressor exposure from translating into mental health problems (i.e., resilience factors) remain poorly understood. This study identifies resilience factors actionable at the workplace and examines the role of cumulative stressor exposure for developing depressive symptoms. Methods. We prospectively followed a convenience sample of HCWs working in Spain. We used a survey to collect self-reported data on (a) sociodemographic characteristics, (b) workplace and COVID-19-related stressors, (c) potential occupational resilience factors, and (d) depression symptoms, at three time points (2020, 2021 and 2022). We operationalised resilience as low stressor reactivity (SR), quantified as individual deviations from the normative relation between exposure to stressors and depressive symptoms. We performed linear and quadratic multiple regression analyses to examine the prospective association between (a) potential resilience factors and (b) prior stressor exposure, with SR across waves. Results. Our sample consisted of 1,872, 1,560, and 431 participants at time points 1, 2, and 3, respectively (median age 42-43 years, 77-80% female). The occupational factors support from colleagues (SOCwork), trust in the workplace (TRUSTwork), and perceived ability to recover from adversity (REC) were prospectively associated with resilience and thus identified as resilience factors. Stressor exposure at baseline was inversely associated with resilience at follow-ups. Conclusions. Occupational strategies that promote key resilience factors and reduce cumulative or prolonged stressor exposure may enhance resilience in times of crisis. The observational design and the large drop in response rates warrant further studies.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/8pf52/" target="_blank">Occupational resilience factors among healthcare workers during the COVID-19 pandemic: a 2-year prospective cohort study</a>
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<li><strong>DEFEN-CE: Social Dialogue in Defence of Vulnerable Groups in Post-COVID-19 Labour Markets. Report on Finland and Sweden</strong> -
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This is a comparative country report on Finland and Sweden for the DEFEN-CE project: Social Dialogue in Defence of Vulnerable Groups in Post-COVID-19 Labour Markets. DEFEN-CE is a research project funded by the Directorate-General for Employment, the European Commission (Grant number: VS/2021/0196). The project investigates the experiences of various stakeholders in the design and implementation of Covid-19-related policies relevant to work and employment in EU member states (Finland, Sweden, the Netherlands, Germany, Latvia, Lithuania, Czechia, Slovakia, Italy and Spain) and two candidate countries, Serbia and Turkey. The aim of the project is to identify the role of social dialogue in facilitating policy implementation that addresses the labour market situation of vulnerable groups in the post-Covid-19 labour markets. Based on this aim, the report seeks to answer three main research questions from a comparative perspective, emphasising similarities and differences in Finland’s and Sweden’s pandemic response, industrial relations (with a focus on social dialogue structures and interactions), policy design, and protection of vulnerable groups. 1. What public policy and social dialogue measures targeting the selected vulnerable groups were implemented for employment and social protection during the Covid-19 pandemic in 2020–2022? 2. To what extent and how did social dialogue play a role in the implementation of the social and employment rights of selected vulnerable groups in the Covid-19 pandemic between 2020 and 2022? 3. What lessons and opportunities does the Covid-19 pandemic yield for strengthening social dialogue in the studied countries? The report combines analysis and findings based on the construction of country-specific Defence Databases (one for Finland and one for Sweden) and qualitative interviews with national stakeholders. The respective database gathers information on more than 30 country- specific Covid-19 policies that have been gathered from international databases (e.g., Eurofound, Eurostat, and OECD/AIAS ICTWSS), national and international policy documents and legislation, reports from trade unions and employers’ organisations, and academic literature. The policies are systematised with information on who adopted the policy (e.g., executive branch, parliament, central bank), policy form (e.g., legislation and statutory regulations, recommendations, social partner agreements), policy area (e.g., labour market, health and safety, and social security), time period, targeted vulnerable groups (based on employment status, social risks, and health safety), and social partners’ involvement.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/6t2qp/" target="_blank">DEFEN-CE: Social Dialogue in Defence of Vulnerable Groups in Post-COVID-19 Labour Markets. Report on Finland and Sweden</a>
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<li><strong>Importations of SARS-CoV-2 lineages decline after nonpharmaceutical interventions in phylogeographic analyses</strong> -
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The onset of the SARS-CoV-2 pandemic marked a period of substantial challenges as the virus and its variants rapidly spread, placing enormous strain on both society and healthcare systems. Prior to the widespread availability of vaccines, non-pharmaceutical interventions such as reducing contacts, antigenic testing, or travel restrictions were the primary means of reducing viral transmission and case numbers, and quantifying the success of these measures is therefore key for future pandemic preparedness. Using SARS-CoV-2 genomes collected in systematic surveillance, we studied lineage importations for the third, pandemic wave in Germany, employing a large-scale Bayesian phylogenetic and phylogeographic analysis coupled to a longitudinal assessment of lineage importation dynamics over multiple sampling strategies. We evaluated the effect of twelve major nationwide nonpharmaceutical interventions (NPIs) on lineage importations and dissemination within the country. All NPIs were followed by reduced lineage importations, with the most substantial decreases seen for the provision of free rapid tests, the strengthening of regulations on mask-wearing in public transport and stores, as well as on internal movements and gatherings. Most SARS-CoV-2 lineages first appeared in the three states with the largest populations and most cases, and from there spread within the country. Importations began to rise before and peaked shortly after the Christmas holidays. Analysis of SARS-CoV-2 data revealed the substantial effects of free rapid tests and obligatory medical/surgical mask-wearing, suggesting these as key for pandemic preparedness, given their relatively few, negative socioeconomic effects. The approach quantifies the relationships between environmental factors at the host population level to viral lineage dissemination from genomic surveillance data, facilitating similar analyses of rapidly evolving pathogens in the future.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.11.10.23298337v1" target="_blank">Importations of SARS-CoV-2 lineages decline after nonpharmaceutical interventions in phylogeographic analyses</a>
</div></li>
<li><strong>Emergence and spread of feline infection peritonitis due to a highly pathogenic canine/feline recombinant coronavirus</strong> -
<div>
Cross-species transmission of coronaviruses (CoVs) poses a serious threat to both animal and human health. Whilst the large RNA genome of CoVs shows relatively low mutation rates, recombination within genera is frequently observed and demonstrated. Companion animals are often overlooked in the transmission cycle of viral diseases; however, the close relationship of feline (FCoV) and canine CoV (CCoV) to human hCoV-229E, as well as their susceptibility to SARS-CoV-2 highlight their importance in potential transmission cycles. Whilst recombination between CCoV and FCoV of a large fragment spanning orf1b to M has been previously described, here we report the emergence of a novel, highly pathogenic FCoV-CCoV recombinant responsible for a rapidly spreading outbreak of feline infectious peritonitis (FIP), originating in Cyprus. The recombination, spanning spike, shows 97% sequence identity to the pantropic canine coronavirus CB/05. Infection is spreading fast and infecting cats of all ages. Development of FIP appears rapid and likely non-reliant on biotype switch. High sequence identity of isolates from cats in different districts of the island is strongly supportive of direct transmission. A deletion and several amino acid changes in spike, particularly the receptor binding domain, compared to other FCoV-2s, indicate changes to receptor binding and likely cell tropism.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.11.08.566182v1" target="_blank">Emergence and spread of feline infection peritonitis due to a highly pathogenic canine/feline recombinant coronavirus</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Evaluation of the Panbio™ COVID-19/Flu A&amp;B Panel to Support Home Use</strong> - <b>Conditions</b>: COVID-19; Influenza A; Influenza Type B <br/><b>Interventions</b>: Diagnostic Test: Panbio™ COVID-19/Flu A&amp;B Panel <br/><b>Sponsors</b>: Abbott Rapid Dx <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Building Engagement Using Financial Incentives Trial - Colorectal Cancer Screening</strong> - <b>Conditions</b>: Health Behavior; Colorectal Cancer; Influenza; COVID-19; Vaccine Hesitancy; Vaccine-Preventable Diseases; Healthcare Patient Acceptance <br/><b>Interventions</b>: Behavioral: Financial incentive for colorectal cancer screening; Behavioral: Financial incentive for flu shot; Behavioral: Financial incentive for COVID-19 shot <br/><b>Sponsors</b>: Tulane University; National Heart, Lung, and Blood Institute (NHLBI) <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Rehabilitation Combined With a Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19</strong> - <b>Conditions</b>: Post-COVID-19 Syndrome <br/><b>Interventions</b>: Procedure: Rehabilitation + maintenance program; Procedure: Rehabilitation only <br/><b>Sponsors</b>: Schön Klinik Berchtesgadener Land; Bavarian State Ministry of Health and Care (Funding); Deutsche Rentenversicherung Bund (German pension insurance) (Design); Betriebskrankenkassen Landesverband Bayern (Bavarian health insurance) (Design) <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Child and Adolescent Mental Health Literacy for Primary Schools Teachers. A Multicomponent Intervention</strong> - <b>Conditions</b>: Child Mental Health <br/><b>Interventions</b>: Behavioral: Child Mental Health Literacy Program <br/><b>Sponsors</b>: Universidad de Valparaiso <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brief Digital Intervention to Increase COVID-19 Vaccination Among Individuals With Anxiety or Depression</strong> - <b>Conditions</b>: Misinformation; Vaccine Hesitancy; Anxiety; Depression; COVID-19 <br/><b>Interventions</b>: Behavioral: Attitudinal inoculation; Behavioral: Cognitive-behavioral therapy-informed intervention; Behavioral: Conventional public health messaging <br/><b>Sponsors</b>: City University of New York, School of Public Health; University of North Carolina, Chapel Hill <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A PhaseⅡ Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine</strong> - <b>Conditions</b>: SARS-CoV-2 Infection <br/><b>Interventions</b>: Biological: COVID-19 mRNA Vaccine (ZSVG-02-O); Biological: COVID-19 mRNA Vaccine (ZSVG-02-O); Biological: COVID-19 Vaccine (Vero Cell) ,Inactivated <br/><b>Sponsors</b>: CNBG-Virogin Biotech (Shanghai) Ltd. <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pilot Randomized Study of RD-X19 Tx Device in Subjects With PCC (Long Covid) in the Outpatient Setting</strong> - <b>Conditions</b>: Post COVID-19 Condition (PCC) <br/><b>Interventions</b>: Device: RDX-19 <br/><b>Sponsors</b>: KNOWBio Inc.; NAMSA <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CPAP Therapy Through a Helmet or a Full Face Mask in Patients With Acute Hypoxemic Respiratory Failure: Cross-over Study</strong> - <b>Conditions</b>: Pneumonia, Bacterial; Respiratory Failure; COVID-19 Pneumonia <br/><b>Interventions</b>: Diagnostic Test: Arterial blood gases; Diagnostic Test: Respiratory rate (RR); Diagnostic Test: Pulseoximeter; Diagnostic Test: Assessment of accessory respiratory muscles work; Diagnostic Test: Esophageal pressure measurement; Diagnostic Test: Discomfort Visual Analog Scale (VAS); Diagnostic Test: Noninvasive blood pressure; Diagnostic Test: Heart rate <br/><b>Sponsors</b>: I.M. Sechenov First Moscow State Medical University <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Investigation of Efficacy and Safety of Electrical Signal Therapy Provided by Dr Biolyse® Device in COVID-19 Disease</strong> - <b>Conditions</b>: COVID-19 Pneumonia; Virus Diseases; COVID-19 <br/><b>Interventions</b>: Device: Signal Therapy provided by Dr.Biolyse device; Other: Liquid Support Treatment <br/><b>Sponsors</b>: AVB Biotechnology <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 1 Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine</strong> - <b>Conditions</b>: SARS-CoV-2 Infection <br/><b>Interventions</b>: Biological: Placebo; Biological: COVID-19 Vaccine (Vero Cell) ,Inactivated; Biological: COVID-19 mRNA Vaccine (ZSVG-02-O) 10 μg; Biological: COVID-19 mRNA Vaccine (ZSVG-02-O) 30 μg; Biological: COVID-19 mRNA Vaccine (ZSVG-02-O) 60 μg <br/><b>Sponsors</b>: CNBG-Virogin Biotech (Shanghai) Ltd.; Shulan (Hangzhou) Hospital <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SAFE Workplace Intervention for People With IDD</strong> - <b>Conditions</b>: Communicable Diseases; Prevention; Workplace Intervention <br/><b>Interventions</b>: Behavioral: SAFE Employment Training <br/><b>Sponsors</b>: Temple University; National Institute on Disability, Independent Living, and Rehabilitation Research <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of an EMDR Intervention on Traumatic and Obsessive Symptoms</strong> - <b>Conditions</b>: Adult ALL; Post-traumatic Stress Disorder; Obsessive-Compulsive Disorder; Disgust; Guilt; Shame <br/><b>Interventions</b>: Behavioral: EMDR <br/><b>Sponsors</b>: University of Pisa <br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lithium Long COVID Dose-finding Study</strong> - <b>Conditions</b>: Long COVID <br/><b>Interventions</b>: Dietary Supplement: Lithium <br/><b>Sponsors</b>: State University of New York at Buffalo <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacokinetics and Safety of GST-HG171 Tablets in Subjects With Impaired and Normal Renal Function</strong> - <b>Conditions</b>: COVID-19 Pneumonia <br/><b>Interventions</b>: Drug: GST-HG171 Tablets <br/><b>Sponsors</b>: Fujian Akeylink Biotechnology Co., Ltd. <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Preoperative Educational Videos on Maternal Stress Whose Children Received Congenital Heart Disease Surgery: During COVID-19 Panic</strong> - <b>Conditions</b>: COVID-19; Educational Videos; Maternal; Uncertainty; Anxiety; Depression; Congenital Heart Disease; Children <br/><b>Interventions</b>: Other: Preoperative educational videos plus routine education; Other: Preoperative routine education <br/><b>Sponsors</b>: Chung Shan Medical University <br/><b>Completed</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beneficial effects of the combination of BCc1 and Hep-S nanochelating-based medicines on IL-6 in hospitalized moderate COVID-19 adult patients: a randomized, double-blind, placebo-controlled clinical trial</strong> - CONCLUSIONS: In conclusion, the combination of BCc1 and Hep-S inhibits IL-6 as a highly important and well-known cytokine in COVID-19 pathophysiology and presents a promising view for immunomodulation that can manage CSS.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety of bempedoic acid in patients at high cardiovascular risk and with statin intolerance</strong> - CONCLUSIONS: Bempedoic acid was well-tolerated compared with placebo. Safety data from the long-term CLEAR Outcomes study reinforce the positive benefit-risk profile of bempedoic acid.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In their absence; intensive care nurses’ experiences of communicating and supporting relatives from a distance</strong> - CONCLUSION: Visiting restrictions in the ICU meant that ICU nurses missed vital information about their patients as a person, which might have had a negative effect on personalizing and centring the patient care. But using a combination of digital and audio tools helped nurses to guide the relatives to a clearer picture of the situation as a whole. The support that nurses were able to provide to relatives was often insufficient due to the visiting restriction and as a consequence, they…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of experiences of the patients discharged from the COVID-19 intensive care unit: a qualitative research</strong> - Making arrangements by learning how intensive care patients feel due to a disease called as fatal worldwide can make it easier for patients to cope with the disease. For this reason, it is important for healthcare professionals to understand the patients who have been infected and discharged during the COVID-19 pandemic. The experiences of the patients may affect the perspective of the disease and cause different changes in the perception of it. This study, which was conducted based on this…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry</strong> - The COVID-19 pandemic caused by SARS-CoV-2, lead to mild to severe respiratory illness and resulted in 6.9 million deaths worldwide. Although vaccines are effective in preventing COVID-19, they may not be sufficient to protect immunocompromised individuals from this respiratory illness. Moreover, novel emerging variants of SARS-CoV-2 pose a risk of new COVID-19 waves. Therefore, identification of effective antivirals is critical in controlling SARS and other coronaviruses, such as MERS-CoV. We…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2</strong> - The COVID pandemic fueled by emerging SARS-CoV-2 new variants of concern remains a major global health concern, and the constantly emerging mutations present challenges to current therapeutics. The spike glycoprotein is not only essential for the initial viral entry, but is also responsible for the transmission of SARS-CoV-2 components via syncytia formation. Spike-mediated cell-cell transmission is strongly resistant to extracellular therapeutic and convalescent antibodies via an unknown…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ceRNA Network Analysis Reveals Potential Key miRNAs and Target Genes in COVID-19-Related Chronic Obstructive Pulmonary Disease</strong> - The continued spread of SARS-CoV-2 has presented unprecedented obstacles to the worldwide public health system. Especially, individuals with chronic obstructive pulmonary disease (COPD) are at a heightened risk of contracting SARS-CoV-2 infection due to their pre-existing respiratory symptoms that are not well-managed. However, the viral mechanism of affecting the expression of host genes, COPD progression, and prognosis is not clear yet.This study integrated the differential expression…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of the covalent SARS-CoV-2 M<sup>pro</sup> inhibitors from antiviral herbs via integrating target-based high-throughput screening and chemoproteomic approaches</strong> - The main proteases (M^(pro) ) are highly conserved cysteine-rich proteins that can be covalently modified by numerous natural and synthetic compounds. Herein, we constructed an integrative approach to efficiently discover covalent inhibitors of M^(pro) from complex herbal matrices. This work begins with biological screening of 60 clinically used antiviral herbal medicines, among which Lonicera japonica Flos (LJF) demonstrated the strongest anti-M^(pro) effect (IC(50) = 37.82 μg/mL). Mass…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An efficient eco-friendly, simple, and green synthesis of some new spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives as potential inhibitors of SARS-CoV-2 proteases: drug-likeness, pharmacophore, molecular docking, and DFT exploration</strong> - INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has caused a global health crisis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious virus that can cause severe respiratory illness. There is no specific treatment for COVID-19, and the development of new drugs is urgently needed.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lipid and cholesterols modulate the dynamics of SARS-CoV-2 viral ion channel ORF3a and its pathogenic variants</strong> - SARS-CoV-2 accessory protein, ORF3a is a putative ion channel which immensely contributes to viral pathogenicity by modulating host immune responses and virus-host interactions. Relatively high expression of ORF3a in diseased individuals and implication with inflammasome activation, apoptosis and autophagy inhibition, ratifies as an effective target for developing vaccines and therapeutics. Herein, we present the elusive dynamics of ORF3a-dimeric state using all-atoms molecular dynamics (MD)…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-fetal globin genes in human erythroleukemia K562 cells</strong> - The COVID-19 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the ongoing coronavirus disease 2019 (COVID-19) pandemic. The SARS-CoV-2 Spike protein (S-protein) plays an important role in the early phase of SARS-CoV2 infection through efficient interaction with ACE2. The S-protein is produced by RNA-based COVID-19 vaccines, that were fundamental for the reduction of the viral spread within the population and the clinical severity of COVID-19. However, the S-protein has been…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Optimizing indoor air quality: CFD simulation and novel air cleaning methods for effective aerosol particle inhibition in public spaces</strong> - In contemporary building ventilation, displacement and mixing ventilation demand high air volumes for rapid virus elimination, resulting in elevated energy consumption. To minimize the spread of viruses and decrease energy consumption for ventilation, this study employed CFD to explore the efficacy of a downward uniform flow field in impeding the transmission of aerosol particles in a high-traffic public facility, like a supermarket. The findings indicate that the downward uniform flow field…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Modulation of the replication of positive-sense RNA viruses by the natural plant metabolite xanthohumol and its derivatives</strong> - The COVID-19 pandemic has highlighted the importance of identifying new potent antiviral agents. Nutrients as well as plant-derived substances are promising candidates because they are usually well tolerated by the human body and readily available in nature, and consequently mostly cheap to produce. A variety of antiviral effects have recently been described for the hop chalcone xanthohumol (XN), and to a lesser extent for its derivatives, making these hop compounds particularly attractive for…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Unmasking an Allosteric Binding Site of the Papain-like Protease in SARS-CoV-2: Molecular Dynamics Simulations of Corticosteroids</strong> - To date, mechanistic insights into many clinical drugs against COVID-19 remain unexplored. Dexamethasone, a corticosteroid, is one of them. While treating the entire corticosteroid database, including vitamins D2 and D3, with cutting-edge computational techniques, several intriguing results are unfolded. From the top-notch candidates, dexamethasone is likely to inhibit the viral main protease (Mpro), with vitamin D3 exhibiting multitarget [Mpro, papain-like protease (PLpro), and nucleocapsid…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Enhancing Employee Job Satisfaction Responding to COVID-19: The Role of Organizational Adaptive Practices and Psychological Resilience</strong> - CONCLUSION: The study provides a new perspective on increasing JS during the COVID-19 pandemic, thereby expanding the scope of the antecedents of employee JS in crisis situations. It also reveals the mediating role of EE and deepens the research on the mechanism by which OAP and PR affect individuals, providing practical guidance for organizations to improve employee satisfaction in sudden public crisis situations.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Escalating Violence Between Israel and Lebanon</strong> - There’s a sense of history repeating itself along the border, where tens of thousands have been displaced and the civilian death toll is climbing. - <a href="https://www.newyorker.com/news/dispatch/the-escalating-violence-between-israel-and-lebanon">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Warnings About Trump in 2024 Are Getting Louder</strong> - A judge’s plea, Hillary Clinton invokes the H-word, and a shock poll in the Times. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/the-warnings-about-trump-in-2024-are-getting-louder">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Lessons of Ohio’s Abortion-Rights Victory</strong> - Tuesday’s election results in that state and elsewhere offer fresh evidence of how the issue is likely to help Democrats in 2024. - <a href="https://www.newyorker.com/news/daily-comment/the-lessons-of-ohios-abortion-rights-victory">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How to Maintain Hope in an Age of Catastrophe</strong> - The psychoanalyst and author Robert Jay Lifton on what seventy years of studying both the victims and the perpetrators of horror has taught him about the human will to survive. - <a href="https://www.newyorker.com/news/the-new-yorker-interview/how-to-maintain-hope-in-an-age-of-catastrophe">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Long Wait of the Families of Hamas Hostages</strong> - The relatives of those held by Hamas “live with a timer now that’s always on.” - <a href="https://www.newyorker.com/news/letter-from-israel/the-long-wait-of-the-hostages-families">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Your phone is the key to your digital life. Make sure you know what to do if you lose it.</strong> -
<figure>
<img alt="Someone just lost their phone. It sinks into a container of water, their hand outstretched but not reaching it." src="https://cdn.vox-cdn.com/thumbor/Brzwl0t-oshotS5Vn-5fAdshalg=/569x0:5121x3414/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72857067/GettyImages_591397373.0.jpg"/>
<figcaption>
A terrifying image, especially if you haven’t prepared for the prospect of suddenly losing your phone. | Peter Cade/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Preparing yourself for the worst is easier than you might think — and it’s never been more important.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Ru92V">
The night before I was supposed to go on a long and well-deserved vacation, something very, very bad happened: I lost my phone. I had a friend over and, I decided, he must have accidentally taken my phone with him when he left. Which was a problem because all methods I had to contact him — including his phone number and address — were in the one thing I now didn’t have.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ru4x5r">
There’s nothing like spending 30 minutes panicking that you’ve lost your phone to make you realize just how devastating that loss can be … and how poorly you’ve prepared for the possibility. Access to just about everything I wasn’t already logged into on my computer was dependent on access to my phone, with my mobile-device-only password manager and multifactor <a href="https://www.vox.com/recode/22419794/authenticator-apps-and-you-authy-google-authenticator">authentication apps</a> and text messages. Actually, had I even backed my phone up to my iCloud account? Didn’t I delete my backups to free up storage space? Was I logged into iCloud on my laptop? Would it even be possible to log in, since my passwords and authentication tools were only on the phone?
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“I don’t think most people prepare for losing their phone,” Sherrod DeGrippo, director of threat intelligence strategy at Microsoft, told Vox. “Which is surprising considering how many people [have] lost their phone, broke their device, or had it stolen. Despite many people having experience here, they aren’t often taking the right precautions.”
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Our phones have become our main — in some cases, only — gateway to so many things. If you lock yourself out of your house, you can call a locksmith to get back in, even if it’s the middle of the night on a holiday. But if you lose your phone, you may lose your keys to a whole lot more, and it may take a while, if ever, to get that access back.
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Ironically, this is especially true if you’ve proactively taken the kind of basic digital security measures most experts would recommend. My efforts to secure my accounts from bad actors — some of which relied on having my phone — might have made it that much harder for me to get back into them.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LHKqXk">
That’s not to say that you shouldn’t do those things — you absolutely should. You just want to make sure you’re preparing for the possibility of a lost device when you set them up. The trick is to make sure you aren’t low-hanging fruit for bad actors, while also not putting that fruit so high up that you can’t reach it if you need it.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qUaGhM">
So I’ve put together a little guide on how to best protect yourself from losing everything if you lose your phone. One thing to keep in mind: These are recommendations for the average person with the average security concerns. If you’ve got different considerations because you’re, say, storing valuable company secrets on your phone, this is not the guide for you.
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<h3 id="EWVr1G">
Make sure you have something to restore: Back that phone up
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EJuDMb">
If you aren’t backing up your phone, there may not <em>be</em> anything to get back if you lose or break it. Some of those things, like photos, may be lost forever. Fortunately, it’s easier than ever to back up your phone.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ppc9KC">
“Backup of data in the digital reality we’re in now is paramount. The impact of no backups is just too dangerous,” DeGrippo said.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PvIAKq">
The old-fashioned way is to connect your phone to your computer. You can find directions on how to do this for your iPhone <a href="https://support.apple.com/guide/iphone/back-up-iphone-iph3ecf67d29/ios">here</a> and your Android <a href="https://www.acronis.com/en-us/blog/posts/how-to-backup-android-phone-to-pc/">here</a>. This is fine, as long as you remember to back it up regularly and you aren’t in a situation where both your phone and your computer are lost or destroyed at the same time.
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That’s why you may want to consider backing it up to the cloud. You can set it to do so automatically and frequently, and your data will be housed in a separate and secure location. There will also, most likely, be a price attached: <a href="https://support.apple.com/en-us/HT211228">Apple</a> and <a href="https://one.google.com/about/storage-backup">Google</a>, for instance, offer a tiny bit of cloud storage for free. For most people, that’s not enough, and you’ll have to shell out for a paid tier.
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“This is generally worth it to seamlessly transfer to another device without data loss in case your handset goes missing forever,” DeGrippo said.
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Your device manufacturer or carrier may have backup options, too, if you want to do some price and feature shopping.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LcruLN">
If you’re especially afraid of losing your backup, you can do what I do: back it up to the cloud as well as your laptop, and then back your laptop up to a password-protected external disk drive that you store in a water- and fire-proof safe. This is probably excessive and unnecessary for most people, but it does protect you from many of the worst-case scenarios.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YmaoBh">
But your work isn’t done yet. You also want to make sure you know how to access that backup if you need it. As I learned, your phone can’t be the sole point of access to your backup. That may also mean making sure that the passwords or authentication codes you need to log into your cloud account can be accessed outside your phone (more on this later).
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<h3 id="n8VuSJ">
Your phone may not be as lost as you think
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These days, phones and many other devices come with locator services, like Apple’s “Find My.” Make sure you’ve both activated it and know where and how to access it on another device (assuming you have one) if the worst happens.
</p>
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This was how I got my phone back, by the way: after a half hour of panicking, I remembered I had Find My set up on my phone and laptop, and used my computer to find my phone (it was under my pillow a few feet away the whole time). You might not be so lucky, but locator services are good for that, too: They often allow you to remotely wipe your device if you fear it’s fallen into the wrong hands. (Hopefully you’ve done your backup homework so you aren’t actually losing anything if you do have to wipe your phone).
</p>
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You can even put a message on the device for whoever has it to see. I can personally attest to the usefulness of that: I left my laptop on a bus years ago. I put a plea for its return (and a reward offer) on the laptop screen. I got my computer back. Instructions on how to use Apple’s “<a href="https://support.apple.com/en-us/HT210400">Find My</a>” service can be found here, and Google has <a href="https://support.google.com/accounts/answer/6160491?hl=en">an option</a> for finding Android devices.
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“Test out these kinds of features so when you really need them, you’ll know exactly how to find them. Further, make sure to enable the find feature on all your devices, so when you lose one, the others can locate it for you,” DeGrippo said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pAUgGY">
You may also want to consider sharing your location (which is really your device’s location) with someone you trust. This concept is bizarre to me, a privacy reporter, but it’s something <a href="https://www.vox.com/culture/23742552/location-sharing-iphone-friends-privacy-risks">plenty of people</a> do, and that experts recommend. And not just for finding a lost phone, either.
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“I do this with my friends and family and it makes me feel safer knowing someone always has a general idea of where I am,” DeGrippo said. “Only share this with people who you trust, under the idea that it is always safer for that person to know where you are.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VdUrJJ">
Remember, you can revoke that access anytime for whatever reason.
</p>
<h3 id="oOnJ4v">
The cybersecurity measures that could make you life harder (but you should still do them)
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PwmiET">
Now that you’ve done everything you can to back your phone up and possibly even locate it if it goes missing, you should think about if and how you can get into all of the apps and services you’ve put on your phone if you don’t have said phone.
</p>
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If you use the same password for virtually everything and don’t have multifactor authentication on your accounts, then it’ll be easy to get back into them, assuming they have a web version and you have access to a second device. Enter that one password that you’ve surely memorized by now and you’re in.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EGOqay">
But! This is also a terrible plan, because it makes it easy for anyone else to get into your account, too. Your password is only as safe as the worst company you’ve entrusted it to. All you need is for one of the countless websites and apps you use that password for to have a data breach, and <a href="https://haveibeenpwned.com/">you’re screwed</a>. <a href="https://www.vox.com/recode/2020/1/28/21080122/avoid-hack-hacker-theft">I speak from experience</a>. Trust me, you don’t want to log into your bank account and see that most of your life savings has been wired out of it because <a href="https://www.vice.com/en/article/8q88k5/hackers-stole-68-million-passwords-from-tumblr-new-analysis-reveals">Tumblr got hacked</a>.
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Choose unique, <a href="https://support.google.com/accounts/answer/32040?hl=en">strong</a> passwords for all of your accounts. That way, if a password is exposed in a data breach, the damage will be limited to just one account. Of course, that would mean you also need to remember all of those passwords. And that’s where a password manager comes in.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5h9OVM">
“I highly recommend everybody has a password manager and learns how to use it,” Casey Oppenheim, co-founder and CEO of security and privacy software developer Disconnect, said.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9XlDFM">
<a href="https://support.apple.com/en-us/HT204085">Apple</a> and <a href="https://passwords.google.com/?pli=1">Google</a> have password managers built right into their services, which makes creating and storing those passwords a quick and simple process. A few taps and you’re good.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kVIfuk">
You can also try a third-party app like LastPass or 1Password, though you might have to pay for them. I used the free version of LastPass, which meant I only had access to it through my phone (the paid version lets you use it on multiple devices). Which was fine until I thought I lost my phone and realized it wasn’t.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U2Ua7S">
“Ideally, it’s a password manager that is not just on your phone, but you can access it on the web,” Oppenheim said. “That’s not as secure, but I think for most people, you want to be able to access your password manager not just locally on your device.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5FTVJJ">
When you set up one of these third-party password managers, you’ll have to give your account a master password — the password to get into your passwords. Do not store this password on your phone, for reasons that should be obvious by now. Keep it somewhere safe and ensure that you’ll remember it if you ever happen to need it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kktsuW">
Even if you can’t get into your password manager, it won’t be the end of the world. Humans are fallible and forgetful, and so we have password reset options. Just make sure you have access to whatever you’ll be getting those reset codes and links on if your phone is gone. If the reset code comes via a text, for example, that’s not very helpful.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QW5BIR">
That brings us to the second security measure that you really should do, but could make things difficult if you lose your phone: multifactor authentication. If you do this through texts (a strategy you <a href="https://www.vox.com/recode/22419794/authenticator-apps-and-you-authy-google-authenticator">might want to rethink</a>) or an authenticator app, you risk losing access to your accounts if you lose your phone. Getting that access back may be difficult, if not impossible.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rL8nVB">
If that’s why you’ve been avoiding using multifactor authentication in the first place, it shouldn’t be. There are easy ways to get authentication codes even if you lose your phone. The trick is to make sure you’ve set that up. Instructions to do so for Authy, for example, <a href="https://support.authy.com/hc/en-us/articles/360016317013-Enable-or-Disable-Authy-Multi-Device">are here</a>. Google Authenticator finally made this option available <a href="https://security.googleblog.com/2023/04/google-authenticator-now-supports.html">in April</a>. If your authenticator app has a master password, save it somewhere safe that isn’t your phone, just like you should for your password manager’s password.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c0iUZW">
If you’re one of the many people who rely on text-based authentication, you can always connect a second device, like a tablet, to your messaging app so you’re still getting texts even if you don’t have your phone. Just remember that’ll mean all of your texts, not just the authentication code ones, will go to that device, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ukiN2a">
Finally, when you set up multifactor authentication on accounts, you should also get recovery codes that will let you back into your account even if you can’t access your authentication method. Here’s how to get them <a href="https://help.instagram.com/1006568999411025">for your Instagram account</a>, for example. But you have to print those out or write them down and keep them somewhere safe — again, that place is not your phone. You could even take screenshots and put those on another device. There’s a bit of a debate within the security community on whether you should be storing master passwords and recovery codes on other devices or offline, but the general consensus seems to be: use the method that works best for you and is relatively secure.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IniuU5">
This is the last step in a process that some people already think has too many steps, but I assure you that, for most people, it’s not that hard and you’ll be very glad you did it if the need ever arises … or very sorry that you didn’t.
</p>
<h3 id="BNBJ0o">
Put a second layer of protection on your apps
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="H3oDlq">
While we’re on the topic of your phone getting lost or stolen, this might be a good time to make sure that someone else still can’t get the keys to your life even if they get into your phone — which <a href="https://www.wsj.com/articles/apple-iphone-security-theft-passcode-data-privacya-basic-iphone-feature-helps-criminals-steal-your-digital-life-cbf14b1a">is a possibility</a> even if you’ve locked it with something like Face ID.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lwB7hp">
Many apps give you the option to add an app-specific lock. When you think about all of the really important things that can be accessed through your phone and the consequences if they fell into the wrong hands — bank accounts, <a href="https://www.vox.com/even-better/23157229/online-scam-venmo-zelle-cashapp-crypto">payment apps</a>, password managers, and authentication apps, to name a few — you may find that’s very much worth the few extra seconds it takes to unlock the apps when you need them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aU4tIK">
If you use Face ID, it really couldn’t be easier. A passcode takes a little longer, and if you go that route, just make sure the code isn’t the same as what you use to unlock your phone, and isn’t something that can be easily guessed. Setting this up is easy (here’s the instructions for Venmo, <a href="https://help.venmo.com/hc/en-us/articles/217532257-PIN-Touch-ID-Setup">for example</a>), and most apps that have the really important stuff, like financial data or access, offer it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TsOqPG">
Finally, once you’ve got all of these measures in place, take a little bit of time to make sure you know what you have, where, and how to use it. When you first realize your phone is lost, broken, or stolen, panic might make you forget all the things you set up to protect and prepare yourself. The tool I ultimately used to find my phone was right there the whole time, but it took half an hour before I remembered it was an option. Part of the reason why is that I hadn’t used the “Find My” app on my computer in years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fgCCpY">
Hopefully, you’ll never need to actually use any of these things, although the chances that you’ll lose access to your phone at some point — even if it’s just lost in your home for half an hour — are pretty good. If you’ve done the work to prepare for the worst, you’ll be in a much better place if it ever happens.
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</p></li>
<li><strong>The case for inviting everyone to everything</strong> -
<figure>
<img alt="A cartoon of large group of people enjoying themselves." src="https://cdn.vox-cdn.com/thumbor/h7akACPkfuW8NMO_teciqbce7sY=/235x0:2014x1334/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72856987/GettyImages_97218200.0.jpg"/>
<figcaption>
Getty Images/CSA Images RF
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</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In a time when loneliness is more pervasive than ever, why not extend an invitation?
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When a friend from college told Melissa Chan that he was coming to visit her in New York City, she was thrilled. It was 2018; she hadn’t seen him in four years, when they had studied abroad in Vienna together. “I was like, ‘Okay, this is a big deal. Let me throw you a party,’” Chan remembers. This friend didn’t know anyone in New York, but that didn’t matter. Chan invited a bunch of her friends, and told them all her usual encouragement to “just bring whoever.” Leading up to the party, her friend mentioned that he had chatted a lot with the two young people in his row on the flight over. “He was like, ‘Oh, is it weird if I invite them to the party?’ And I was like, ‘No, no, that’d be so fun.’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P5OV6y">
And it <em>was</em> fun. Having two strangers who were totally unconnected from anyone, save for the serendipitous flight seating plan, made for a great icebreaker, and it sparked a lot of dynamic conversation. Although Chan didn’t keep in touch with the pair, she and her visiting friend remember that night fondly. It sort of encapsulated Chan’s general philosophy when it comes to parties and socializing: Be free and easy with your invitations. “When there’s more of a melting pot at an event, it’s just a more interesting environment and way more conducive to diverse conversations and making new friends,” she says.
</p>
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The idea of hosting or even attending a large social event where there will be plenty of strangers, or people from disparate friend groups, can generate a lot of anxiety for some. It can be easy to overthink about who may not get along, or catastrophize the potential awkwardness of talking to groups of people with whom you have little in common. Research, though, suggests that a reluctance to reach out and connect is <a href="https://myscp.onlinelibrary.wiley.com/doi/full/10.1002/jcpy.1336">unwise</a>, that we <a href="https://psycnet.apa.org/record/2014-28833-001">underestimate others’ interest</a> in connecting, and that people like Chan are really onto something. Of course, you cannot invite <em>everyone</em> to everything; an intimate game night will by definition include only a few people, and your dinner parties will be constrained to your number of place settings. If you are able to include more people, though, research suggests you should, and that it could benefit all involved. Especially in a purported <a href="https://www.vox.com/policy/2023/5/3/23707936/surgeon-general-loneliness-epidemic-report">epidemic of loneliness</a> and isolation, putting yourself in a place to form new and surprising connections could lead to revelations. So why not broaden the invitation?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CUqwOl">
Broadening the invitation means more than just including new acquaintances or strangers at social events. It can also mean reaching out to people you haven’t spoken to in a while, welcoming neighbors who you haven’t really socialized with before, or just encouraging your friends to bring plus-ones.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mh3Uke">
Inviting someone to an event where they may not know others can feel awkward, especially if it’s been a long time since you last spoke or if you just don’t know them very well. But research shows that you should take heart — chances are that person will be way happier to hear from you than you expect. <a href="https://www.apa.org/pubs/journals/releases/psp-pspi0000402.pdf">One study</a> found that people we know are consistently happier to hear from us than we anticipate, especially when the overture is more surprising and unexpected. “People are much more reluctant to reach out to old friends than they should be,” says Lara Aknin, a professor of social <a href="https://www.vox.com/psychology">psychology</a> at Simon Fraser University in Canada who studies how relationships affect well-being. But despite the research, “It’s surprisingly hard to get people to move the needle on this.”
</p>
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Another thing people commonly find challenging is reaching out to people when it seems like they aren’t very close. Still, asking to hang out with those beyond your closest circles of friends can reap so many other rewards, Aknin says. “I think it’s intuitive to us that our strong relationships matter. But we overlook all these possibilities for contact with people who are all around us all the time,” she says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mku5lQ">
For example, <a href="https://journals.sagepub.com/doi/10.1177/0146167214529799">one study</a> found that people who mingled with more loose acquaintances or strangers in a day reported better moods and a higher sense of communal belonging. Similarly, a <a href="https://www.hbs.edu/faculty/Pages/item.aspx?num=62955">paper</a> assessing people’s “social portfolios” found that people whose regular social interactions ran the gamut of closeness (all the way from family members to coworkers to strangers) reported higher life satisfaction and better quality of life than those with less diverse social lives. Researchers have also <a href="https://journals.sagepub.com/doi/abs/10.1177/0956797618783714">documented</a> what they call “the liking gap,” where after conversing with a stranger, “people systematically underestimated how much their conversation partners liked them and enjoyed their company.” Some introverts may expect to feel worse after a social interaction, but <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199146#sec005">even they benefit</a>; all but the extremely introverted tend to feel happier and more energized after socializing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kkUBie">
Interacting with a wide circle of loose friends and acquaintances is also valuable because each person provides more information about the world outside your bubble, says <a href="https://www.psy.ox.ac.uk/people/robin-dunbar">Robin Dunbar</a>, a psychologist and author at the University of Oxford. A lot of important context gets to us “through the information percolating through the friends in your network,” he says. This can be anything from the next fashion fad to a different worldview or philosophy.
</p>
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In other words, even people with little regular presence in your life can have a big impact on your happiness. So for people who tend to have diverse but disparate friend groups, this means that hosting events where you bring all your worlds together not only benefits yourself, but also “could reasonably be interpreted as a kind of service to others,” says Aknin.
</p>
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“Generally, the more connected our networks are, with lots of tendrils and different camps, the better individuals feel and the higher they report their well-being to be,” she says. And there’s “a ton of work about how just belonging to multiple groups is strongly associated with health and happiness.” Researchers have linked belonging to multiple social groups — like recreational sports teams or book clubs — with <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124609">higher self-esteem</a> and <a href="https://www.sciencedirect.com/science/article/pii/S0277953613005194">lower rates of depression</a>.
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Auburn Scallon, a writer in Jackson Heights, New York, loves socializing with diverse mixes of friends. For her, hosting these events brings an added ease of scheduling: “If I met up with everyone I loved only one-on-one, I’d see each person once a year,” she says. Getting everyone together in a big to-do means “I can see the people I love more often.” Not everyone you invite will be able to attend everything, but that’s okay, Scallon says — she makes it clear her invites are low-stakes, and she doesn’t take a “no” personally. She remembers a friend in the early 2000s who, after turning down the fifth invite in a row said: “But please keep inviting me! I’ll make it eventually.” That sort of response is totally welcome, she says; she’d love to see them, but if not now, there will always be next time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8lhecH">
It can also be cool to observe how people are when they’re talking to people whom they likely wouldn’t have met otherwise, says Scallon. It’s another thing she loves about mixing her friends: “You see a different side of people.” And it’s always thrilling when people end up connecting and tell her, “I enjoyed meeting so-and-so,” she says. Science, again, backs her up. <a href="https://www.hbs.edu/ris/Publication%20Files/Anik%20Norton%202014_69c76077-9dc5-43ef-a28e-cdbe968c892f.pdf">Research from 2014</a> found that playing friend matchmaker increases happiness and well-being. And the more unlikely the match, the more rewarding facilitating that connection is.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bbLs0I">
If you have two friends who you think might get along, it can be easier to introduce them in a larger, more casual group setting, says Chan. Counterintuitively, it seems like larger groups can put people more at ease because it takes the pressure off of every little interaction, she thinks. Regardless of whether those bonds turn into long-term relationships, “it’s still a moment of human connection enjoyable in the moment, and that’s inherently enjoyable.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JZQPx2">
If two friends do hit it off, that opens up doors for you to invite them both to something smaller and more intentional, Scallon says. It can be trickier and more awkward to invite two people who don’t know each other to hang out when it’s just the three of you. But if they’ve already met and got along, then you’re in the clear.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="llTnP4">
Regardless of the size and scale of your social planning, Scallon says it’s important to stay mindful of certain things. She remembers living in Seattle and asking a friend along to a function — it was only when they got there that Scallon realized her friend was “the only person of color in a room full of white people.” She felt so apologetic and now tries to think about these things in advance. If she invites someone shy to a big gathering, “I try to be intentional about introducing people and providing context for who they’re talking to.” She’ll host things with open-ended time periods so that friends with work- or family-related time constraints can come whenever they prefer, and she’ll try to communicate as clearly as she can what vibe people can expect.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kmIl2l">
Part of communicating that vibe includes Covid-safety expectations. Scallon is still extremely Covid-conscious, so social gatherings for her have been few and far between ever since 2020, and it’s been several years since she’s organized a large social event. These days, if she does socialize, it’s as a guest — “it’s easier to be safe on my own than to impose precautions on my own guests,” she says. But it’s not the same. Taking precautions while it seems that others have resumed socializing with abandon is isolating, says Scallon, and over the past few years she’s felt a slight shift in herself; she thinks she’s become a little more reserved and introverted as her social muscles grow cold from disuse. But “I do miss it,” she says — the hosting and organizing and bringing friends together. It’ll be exciting when the time comes to resume the practice and reconnect.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YtQldR">
Socializing in big groups of people is intimidating. And people are terrible at predicting what social situations will make them happy, says Aknin. “Honestly, I also think we have overly pessimistic views of other people,” she adds. It comes from a reasonable place: “We’re trying to avoid the worst-case scenario which could be a big flop, an awful conversation. But many times we are really positively surprised by other people, by their kindness, by their warmth, by their appreciation, and by our own abilities.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wD2JLO">
Thankfully, the <a href="https://www.sciencedirect.com/science/article/pii/S0022103122000750">research</a> suggests that the more we practice interacting with strangers in novel situations, the easier it becomes and the more positively we begin to view future interactions. “The more we’re exposed to something, the more we like it,” says Aknin.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uC5ZDL">
Being more open to mixing your social groups and extending invitations to people even if you don’t know them very well is about giving yourself, and your friends, more opportunities for connection. You simply cannot <a href="https://www.vox.com/friendship">make friends</a> with someone if you never cross paths with them, or if you don’t allow for time to converse and find common ground, says Aknin.
</p>
<p class="c-end-para" data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UPTeDj">
Yes, broadening the invitation can mean embracing unknowns, Chan says, but who’s to say those potential unknowns won’t be great? By extending invitations beyond your inner circle, beyond what is known and familiar, you at least give yourself the possibility to make a new or interesting connection. If you don’t, those possibilities are zero, and that would be the greater shame, she says: “People are more capable than you give them credit for.”
</p></li>
<li><strong>Israel’s humanitarian pauses in Gaza, explained</strong> -
<figure>
<img alt="Encircled By Israel, Gaza Faces Catastrophe As Death Toll Soars" src="https://cdn.vox-cdn.com/thumbor/vC6D6X-zPYoUJEelqmZLkjw_tDI=/320x0:5440x3840/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72855852/1786001062.0.jpg"/>
<figcaption>
Ahmad Hasaballah/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Civilians continue to flee south as fighting around hospitals increases
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q2xAo9">
<a href="https://www.vox.com/israel">Israel</a> has agreed to four-hour daily humanitarian pauses <a href="https://www.cnn.com/2023/11/09/politics/israel-pauses-gaza-white-house/index.html">in areas of northern Gaza</a> as US officials announced Thursday. The pauses, meant to allow civilians to safely leave for southern <a href="https://www.vox.com/2018/11/20/18080046/gaza-palestine-israel">Gaza</a>, comes amid an increasingly dire humanitarian crisis as Israel continues to bombard one of the most densely-populated places on the planet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k88ibN">
The windows have so far <a href="https://apnews.com/article/israel-hamas-war-news-11-10-2023-98025565691cc44304074b3e25d11ae5">allowed 100,000 people to move</a>, according to Israeli officials — but it’s not clear that the safe routes and pauses are enough as more than 11,000 <a href="https://www.vox.com/palestine">Palestinians</a> have been killed and calls for a ceasefire grow louder.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hgufW3">
The new agreement is the result of US pressure on Israeli Prime Minister Benjamin Natanyahu, with National Security Council spokesperson John Kirby telling reporters that the new policy is due to President Joe Biden’s “personal leadership and diplomacy.” But Biden was apparently unable to secure the more prolonged ceasefire he sought to secure the release of hostages, <a href="https://www.politico.com/news/2023/11/09/israel-humanitarian-pauses-gaza-00126355">Politico reported</a> Thursday. The US <a href="https://www.axios.com/2023/11/04/us-israel-aid-military-funding-chart">continues to supply military aid to Israel</a>, <a href="https://www.justsecurity.org/90010/a-law-and-policy-guide-to-us-arms-transfers-to-israel/">as it has for decades</a>, and Biden has requested an<a href="https://www.axios.com/2023/11/04/us-israel-aid-military-funding-chart"> additional $14.3 billion</a> to finance Iron Dome and other air and missile defense systems.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6ulfR5">
US officials expect that the daily pauses will also allow for increased humanitarian aid to enter Gaza, as residents have received only a fraction of the basic goods via aid organizations that they did previous to the war. Israel has blockaded Gaza for the past 16 years, since <a href="https://www.vox.com/politics/2023/10/10/23911661/hamas-israel-war-gaza-palestine-explainer">Hamas</a> took control of the territory, and food, medicine, and fuel are supplied by the United Nations and other agencies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EDOQFd">
While pauses offer some measure of safety for people fleeing Israel’s operations in northern Gaza, the totality of the humanitarian crisis there remains overwhelming. More than 11,000 Palestinians have been killed by Israeli forces over the past month of fighting in Gaza, and supplies like food, clean water, and fuel are dangerously limited in the south, where some 2 million people are expected to shelter as Israel prosecutes its war against Hamas.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pVuO5f">
Over the past three weeks Israel conducted overnight raids and bombing campaigns in northern Gaza before launching a phased assault. The Israel Defense Forces announced earlier this week that it had encircled Gaza City, the northern population center it has deemed the center of Hamas operations.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B1Ldd8">
On Friday, just a day after the humanitarian pauses were announced, fighting broke out around hospitals in Gaza City, including at al-Shifa hospital, where hundreds of gravely ill and wounded patients are being treated and thousands of civilians have been sheltering — putting them in serious danger and casting doubt on the efficacy of the humanitarian pauses.
</p>
<h3 id="MI8kMm">
Getting people out, getting aid in
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dQtxmY">
Israel initially gave the estimated 1 million people living in the northern part of the Gaza Strip 24 hours to evacuate to the south so that it could prepare to conduct military operations there, including launching airstrikes and <a href="https://www.nbcnews.com/news/world/israel-gaza-hamas-tunnels-fighters-war-rcna123708">destroying tunnels used by Hamas</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="07NpHC">
The original evacuation demand, according to several <a href="https://www.hrw.org/news/2023/10/16/why-israels-gaza-evacuation-order-so-alarming">humanitarian organizations</a> including the UN, was impossible to execute, particularly given the ongoing combat, poor infrastructure damaged by previous conflict, lack of fuel for cars given the siege Israel declared on the territory starting October 9, and sheer number of people moving within one of the most densely populated places on earth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gbmZfr">
<a href="https://apnews.com/article/israel-hamas-war-news-11-10-2023-98025565691cc44304074b3e25d11ae5#:~:text=More%20than%20two%2Dthirds%20of,to%20military%20spokesman%20Jonathan%20Conricus.">Hundreds of thousands</a> of Palestinians have moved to the south since that initial call for evacuations, though thousands remain, many sheltering at hospitals like al-Shifa near Gaza City.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fZe8FO">
Details about the location and time of the pauses are unclear, as is the number of days the pauses will occur but Kirby <a href="https://www.cbsnews.com/news/israel-gaza-daily-4-hour-humanitarian-pauses-civilians/">told reporters Thursday</a> that the timing of the pauses will be announced three hours prior to their beginning each day.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SMsfoX">
Following Defense Minister Yoav Gallant’s call for a siege on Gaza, aid groups as well as governments like Qatar and the US have tried to negotiate for aid to come into the territory through the Rafah crossing on Gaza’s southern border with Egypt. The siege meant that no food, medicine, medical equipment, potable water, or fuel could get into the territory; electricity and, at times, telecommunications were cut as well. Without electricity or fuel, Gaza’s water desalination plants cannot produce potable water, and hospitals can operate in only limited capacities despite the critical need for health services in a war zone.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rs9ert">
Since October 9, negotiations have allowed for some aid to get through — about 100 trucks of supplies per day, according to Special Envoy for Middle East Humanitarian Issues David Satterfield, compared with around 500 per day prior to the war. “Now, we understand even 150 trucks a day just meets the bare minimum to provide basic survival humanitarian assistance,” <a href="https://www.state.gov/special-online-press-briefing-with-u-s-special-envoy-for-middle-east-humanitarian-issues-david-satterfield/">Satterfield said in a press briefing Thursday</a>. “Much more is needed beyond that. There needs to be commercial goods restocking shelves, bakeries need to reopen with all that they need in terms of supplies, cooking gas for that purpose.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bIh8mU">
Satterfield also told reporters that fuel stores in southern and central Gaza had been made available via the UN Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) and were supplying water desalination facilities in south and central Gaza, and two water pipelines from Israel had been restored.
</p>
<h3 id="w3GBtK">
The bigger picture: Gaza is still being devastated, and it’s only getting worse
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rMYWsL">
Thus far in the fighting more than 11,000 people have been killed according to the Gaza Health Ministry; more than 4,500 are said to be children and over 3,000 women, the UN Office for the Coordination of Humanitarian Affairs (OCHA) <a href="https://www.ochaopt.org/content/hostilities-gaza-strip-and-israel-flash-update-35">reported in a bulletin from November 10</a>. “On average, a child is killed every 10 minutes in Gaza,” Tedros Adhanom Ghebreyesus, head of the World Health Organization, said in a Friday briefing to <a href="https://twitter.com/WHO/status/1723070173132070953">the UN Security Council</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4GnPS5">
IDF airstrikes and operations remain the major cause of death and casualties; though the military says it is targeting Hamas terrorists, <a href="https://www.unocha.org/explosive-weapons-populated-areas">90 percent of the casualties are civilians when explosives are used in populated areas, according to the UN</a>. The IDF has <a href="https://www.youtube.com/watch?v=zY6lnbnubzw">conducted multiple operations in the Jabalia refugee camp in Gaza</a>, calling it a Hamas stronghold and “hotbed of terrorist activity,” according to IDF spokesperson Lt. Col. Jonathan Conricus. “Nobody can claim that they didn’t know this was coming,” he said, emphasizing that residents had been told to evacuate for two weeks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NQ2ZIc">
<a href="https://www.nytimes.com/2023/11/10/world/middleeast/israel-gaza-hospitals-besieged.html">On Saturday, fighting</a> <a href="https://www.wsj.com/livecoverage/israel-hamas-war-gaza-strip-2023-11-08/card/map-israeli-troop-presence-in-gaza-E2TTAAyx9Zz4G4MVJFgj">near hospitals in Gaza including al-Shifa</a> continued, causing chaos and panic. The IDF has commanded the evacuation of al-Shifa hospital, saying that Hamas operates in tunnels beneath the facility, which both Hamas and hospital leadership deny. Al-Shifa has about 700 beds, but is currently treating 5,000 people, according to Medecins Sans Frontieres. <a href="https://www.aljazeera.com/news/2023/11/10/which-of-gazas-hospitals-is-israel-threatening">Hamas claims the hospital is sheltering around 40,000</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ceHaA2">
Reports of heavy bombardment at al-Shifa continued Friday night and into Saturday. “The situation in al-Shifa is truly catastrophic,” Ann Taylor, head of mission in the Occupied Palestinian Territories <a href="https://www.msf.org/gaza-patients-and-medical-staff-trapped-hospitals-under-fire">said in a statement</a>. “We call on the Israeli Government to cease this unrelenting assault on Gaza’s health system. Our staff and patients are inside Al-Shifa hospital where the heavy bombing has not stopped since yesterday.” MSF staff reported constant bombardment and people being shot as they tried to leave the hospital.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LmlxWt">
“There is no siege, I repeat no siege, on Shifa Hospital. The east side of the hospital is open for the safe passage of Gazans who wish to leave the hospital,” IDF spokesperson Daniel <a href="https://www.timesofisrael.com/liveblog_entry/idf-says-it-will-help-evacuate-babies-from-shifa-hospital-tomorrow-hamas-losing-control-of-north-gaza/">Hagari said in a Saturday briefing</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s5vLGm">
“We’re speaking directly and regularly with the hospital staff. The staff of Shifa Hospital has requested that tomorrow we will help the babies in the pediatric department to get to a safer hospital. We will provide the assistance needed,” Hagari said. Two babies in the neonatal unit died after the hospital ran out of fuel Saturday, <a href="https://www.bbc.com/news/live/world-middle-east-67385263?ns_mchannel=social&amp;ns_source=twitter&amp;ns_campaign=bbc_live&amp;ns_linkname=654f92741ec331355f9628ea%26Where%20things%20stand%20in%20Israel%20and%20Gaza%262023-11-11T19%3A06%3A34.636Z&amp;ns_fee=0&amp;pinned_post_locator=urn:asset:cf664e07-5d77-4eed-942e-c8e333bb0f2e&amp;pinned_post_asset_id=654f92741ec331355f9628ea&amp;pinned_post_type=share">according to the BBC</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GdEkR4">
And though more than 850,000 people have left northern Gaza so far according to the IDF, “Hundreds of thousands of people remaining in the north are struggling to survive,” OCHA reported. “Consumption of water from unsafe sources raises serious concerns about dehydration and waterborne diseases. The World Food Programme (WFP) has expressed concern about malnutrition and starvation.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="01Y4JN">
In the midst of the ongoing devastation, French President Emmanuel Macron on Friday called for a ceasefire in <a href="https://www.bbc.com/news/world-europe-67356581">an interview with the BBC</a>. “There is no other solution than first a humanitarian pause, going to a ceasefire, which will allow [us] to protect… all civilians having nothing to do with terrorists.”
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IND vs NED | India wins toss, opts to bat against Netherlands</strong> - India will be eyeing their ninth win in a row ahead of the semifinal against New Zealand on November 15</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India will have to wait for another three World Cups if they don’t win it this time: Shastri</strong> - Ravi Shastri feels the current lot of bowlers is the best India have ever had</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glenn Maxwell | Demolition man</strong> - Chasing Afghanistan’s 291 for five, Australia was sinking at 91 for seven on Nov. 7 when Maxwell found a patient ally in Pat Cummins and hammered an unbeaten 201 to turn around the match</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inyouwebelieve, who has been well-prepared, is expected to score in the Kabini Cup</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tottenham allows stoppage-time goals in 2-1 loss to Wolverhampton in Premier League</strong> - Wolverhampton scored twice in stoppage time to beat Tottenham 2-1 in the Premier League, handing Spurs back-to-back losses for the first time this season</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PM Trudeau says ‘fight’ with India not something Canada wants right now; seeks to ‘work constructively’ with New Delhi</strong> - Mr. Trudeau also alleged that India violated the Vienna Convention as over 40 Canadian diplomats were shifted from India after New Delhi threatened to strip them of their diplomatic immunity</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>EAM Jaishankar arrives in London on five-day U.K. visit</strong> - While in the U..K, the EAM is expected to attend an event at Lord’s Cricket Ground and address a Deepavali Reception organised by the High Commission of India in London</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Many Bihar cities record AQI over 300, BSPCB tells DM to enforce laws to check air pollution</strong> - Other Bihar districts where the AQI was in the very poor category included: Hajipur (356), Purnea (350), Katihar (350), Motihari (341)</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dal Lake blaze: Mehbooba visits affected families, demands soft loans for rebuilding houseboats</strong> - Mehbooba Mufti requested the Jammu and Kashmir administration headed by Lieutenant Governor Manoj Sinha to provide soft loans to the affected families so that they can rebuild their houseboats</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Seven injured by leopard stuck inside house</strong> - Officials said the leopard had entered a house in Brookland Estate in Coonoor early Sunday morning while attempting to hunt dogs being raised in the estate</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>French march against antisemitism shakes up far right and far left</strong> - Far-right leader Marine Le Pen plans to rally alongside major political parties but the far left refuses.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Macron calls on Israel to stop killing Gaza’s women and babies</strong> - In an exclusive BBC interview, the French president said a ceasefire would be in Israel’s interest.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Iceland volcano: Emergency declared over volcano Fagradalsfjall eruption concerns</strong> - Thousands are asked to evacuate from a town over fears magma has spread underground.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>International mafia bust shows US-Italy crime links still strong</strong> - While decades of prosecutions weakened the US and Italian mafia, transatlantic relations remain strong.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sinn Féin ard fheis: Mary Lou McDonald calls for Citizens’ Assembly on Irish unity</strong> - Mary Lou McDonald tells the party conference she wants to see “orange and green reconciled”.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mummified baboons point to the direction of the fabled land of Punt</strong> - Egyptians often mentioned a trading partner but neglected to say where it was. - <a href="https://arstechnica.com/?p=1982985">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protective vaccination rates falling out of reach in US; exemptions hit record</strong> - Vaccination exemptions among kindergartners rose from 2.6% to a record high of 3%. - <a href="https://arstechnica.com/?p=1983182">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Alexa just cost Amazon another $46.7 million</strong> - “Alexus” voice assistant demoed 6 months before Alexa reveal, patent lawsuit said. - <a href="https://arstechnica.com/?p=1983039">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dealmaster: Apple watches, TV mega-deals, headphone sales, and more</strong> - Black Friday keeps coming, tech gear keeps dropping. - <a href="https://arstechnica.com/?p=1983006">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Humane AI Pin is a bizarre cross between Google Glass and a pager</strong> - The Humane AI pin has no screen, no apps, and a creepy in-your-face camera. - <a href="https://arstechnica.com/?p=1982491">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A soldier returns home to his wife after a year-long deployment overseas.</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He wants to show her how he managed to go a year without having sex with anybody else. “So how did you do it?” she asks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I trained my dick to respond to drill commands like so.” He undoes his belt and drops his trousers. “Dick, ten-HUT!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His penis springs straight up, erect and raring to go. “Dick, at ease!” His penis soon becomes flaccid. “Now you try!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His wife tries it—“Dick, ten-HUT!”, and his penis springs to life again.
</p>
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“Dick, at ease!” The soldier’s penis relaxes and softens. “Oh, we need to show the neighbors this!” The wife leaves and comes back with their neighbor, an attractive 20-something woman. His wife encourages her to try telling the soldier’s penis to come to attention and stand at ease.
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“Dick, attention!” the neighbor commands. The soldier’s penis, as expected, hardens.
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“Dick, at ease!” But his penis does not go down. “Dick, at ease!”
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The soldier looks down at his penis, still erect. “Dick, at ease!”
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But the military man’s member refuses to go down, so he runs away into the bathroom. His wife follows him and sees him furiously masturbating.
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“Honey, what are you doing?” she asks with a hint of worry in her voice.
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The soldier replies, “He’s not following my orders so I’m giving him a dishonorable discharge!”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/marxman28"> /u/marxman28 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/17t9erl/a_soldier_returns_home_to_his_wife_after_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/17t9erl/a_soldier_returns_home_to_his_wife_after_a/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Robot Bartender makes a great Martini</strong> - <!-- SC_OFF --></p>
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A guy goes into a bar, there’s a robot bartender. The robot says, “What will you have?” The guy says, “Martini.” The robot brings back the best martini ever and says to the man, “What’s your IQ?” The guy says, “168.” The robot then proceeds to talk about physics, climate change, and AI machine language.
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The guy leaves, but he is curious. So he goes back into the bar. The robot bartender says, “What will you have?” The guy says, “Martini.” Again, the robot makes a great martini, gives it to the man and says, “What’s your IQ?” The guy says, “100.” The robot then starts to talk about NASCAR, hunting rifles, and monster trucks.
</p>
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The guy leaves but finds it very interesting, so he thinks he will try it one more time. He goes back into the bar. The robot says, “What will you have?” The guy says, “Martini,” and the robot brings him another great martini. The robot then says, “What’s your IQ?” The guy says, “Uh, about 50.” The robot leans in real close and says, “Isn’t it terrible the way Biden stole the election?”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Drysurferrr"> /u/Drysurferrr </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/17t9mm6/robot_bartender_makes_a_great_martini/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/17t9mm6/robot_bartender_makes_a_great_martini/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A physicist, an engineer and a statistician are out hunting.</strong> - <!-- SC_OFF --></p>
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Suddenly, a deer appears 50 meters away.
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The physicist does some basic ballistic calculations, assuming a vacuum, lifts the rifle, and the bullet lands 5 meters short.
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The engineer adds fudge factor for air resistance, and lifts the rifle a bit higher, and the bullet lands 5 meters long.
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“We got’tem!” yelled the statistian.
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Erkhes1223"> /u/Erkhes1223 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/17td6k2/a_physicist_an_engineer_and_a_statistician_are/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/17td6k2/a_physicist_an_engineer_and_a_statistician_are/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I stopped at the bar after work the other day…</strong> - <!-- SC_OFF --></p>
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…and there were three doctors at a table slamming drinks.
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They were bragging about their best surgeries ever.
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The first doctor said listen up. "One time a guy came in who was in a terrible wood cutting accident.
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The guy lost his right arm, but I sewed him up in 3 hours. Now he’s is a major league pitcher."
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The second doctor said, "One time I was working in the ER and this dude came in who lost his leg in a farming accident.
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I sewed him up in 2 hours and now he’s is an Olympic runner."
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The last doctor said, "That ain’t nothing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
One time my wife and I were heading to Walmart and the car in front of us slid off the road and into a cow pasture.
</p>
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The dude went through the front windshield and split his head wide open and his brains were all over the place.
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I sprung into action and scooped up all the brains and all the cow patties and shoved it right back in his head.
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I sowed him up in less than 45 minutes, and now he is the president of the United States of America."
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/skirts988"> /u/skirts988 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/17tfdcq/i_stopped_at_the_bar_after_work_the_other_day/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/17tfdcq/i_stopped_at_the_bar_after_work_the_other_day/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I went on a date with a blonde woman last night.</strong> - <!-- SC_OFF --></p>
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“Do you have any kids?” she asked.
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“Yes,” I replied. “I have one child that’s just under two.”
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Then she said, “I might be blonde, but I know how many one is.”
</p>
</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/TheQuietKid22"> /u/TheQuietKid22 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/17tgx2n/i_went_on_a_date_with_a_blonde_woman_last_night/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/17tgx2n/i_went_on_a_date_with_a_blonde_woman_last_night/">[comments]</a></span></p></li>
</ul>
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