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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Close kin influence COVID-19 precautionary behaviors and vaccine acceptance of older individuals</strong> -
<div>
The family plays a central role in shaping health behaviors of its members through social control and support mechanisms. We investigate whether and to what extent close kin (i.e., partner and children) have mattered for older people in taking on precautionary behaviors (e.g., physical distancing) and vaccination during the COVID-19 pandemic in Europe. Drawing on data from the Survey of Health, Ageing and Retirement in Europe (SHARE), we combine its Corona Surveys (June-August 2020 and June-August 2021) with pre-COVID information (October 2019-March2020). We find that having close kin (especially a partner) is associated with a higher probability of both adopting precautionary behaviors and accepting a COVID-19 vaccine. Results are robust to controlling for other potential drivers of precautionary behaviors and vaccine acceptance, as well as to accounting for co-residence with kin. Our findings suggest that policy makers and practitioners may differently address kinless individuals when promoting public policy measures.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/b3rn2/" target="_blank">Close kin influence COVID-19 precautionary behaviors and vaccine acceptance of older individuals</a>
</div></li>
<li><strong>The effect of vasopressors on mortality in critically ill patients with COVID-19: A systematic review and meta- analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Purpose: The effect of vasopressors on mortality of critically ill patients with COVID-19 has not been studied extensively. Methods: A systematic search of PubMed, Scopus, and clinicaltrials.gov was conducted for relevant articles until January 2022. Eligibility criteria were randomized controlled and non-randomized trials. The primary outcome was all-cause mortality at 28 days or 30 days. The quality of studies was assessed using the MINORS tool. Paired meta- analysis was used to estimate the pooled risk ratios along with their 95% Confidence Interval. Results: In total, 33 studies were included. Twenty-one studies with a total population of 7900 individuals provided data on mortality. Patients who received vasopressors were statistically significantly more likely to die compared to those who did not receive vasopressor therapy [RR (95%CI): 4.26 (3.15, 5.76); p&lt;0.001]. This result remained statistically significant regardless of the in-hospital setting. In-hospital and 30-day mortality were statistically significantly higher in patients who received vasopressors [RR (95%CI): 4.60 (2.47, 8.55); p&lt;0.001 and RR (95%CI): 2.97 (1.72, 5.14); p&lt;0.001, respectively]. Four studies provided data on specific vasopressors; the highest mortality rate was observed in patients treated with vasopressin or epinephrine, while patients receiving angiotensin-II as a sole or second-line vasopressor agent had the lowest mortality rate. Also, analysis of 10 studies with a total population of 3519 individuals revealed that patients who received vasopressors were statistically significantly more likely to experience acute kidney injury [RR (95%CI): 3.17 (2.21, 4.54); p&lt;0.001]. Conclusion: Vasopressors have detrimental effect on survival of critically ill patients with COVID-19.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.27.22275715v1" target="_blank">The effect of vasopressors on mortality in critically ill patients with COVID-19: A systematic review and meta-analysis</a>
</div></li>
<li><strong>A pharmacoepidemiological study of myocarditis and pericarditis following mRNA COVID-19 vaccination in Europe</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objective: To assess myocarditis and pericarditis reporting rate as adverse drug reactions (ADRs) for the messenger ribonucleic acid (mRNA) coronavirus disease 2019 (COVID-19) vaccines authorized in Europe. Methods: Data on myocarditis and pericarditis related to mRNA COVID-19 vaccines (period: January 1, 2021 - February 11, 2022) were collected from the EudraVigilance database and combined with the European Centre for Disease Prevention and Control9s (ECDC) vaccination tracker database. The reporting rate was expressed as 1 million individual vaccinated-days with a corresponding 95% confidence interval (CI), and an observed-to-expected (OE) analysis was performed to check if there was an excess risk for myocarditis or pericarditis following mRNA COVID-19 vaccination. Results: The reporting rate of myocarditis per 1 million individual vaccinated-days in the study period was 17.27 (95% CI, 16.34-18.26) for the CX-024414 vaccine and 8.44 (95% CI, 8.18-8.70) for TOZINAMERAN vaccine. The reporting rate for pericarditis per 1 million individual vaccinated-days in the study period was 9.76 (95% CI, 9.06-10.51) for the CX-024414 vaccine and 5.79 (95% CI, 5.56-6.01) for TOZINAMERAN vaccine. The OE analysis showed that both vaccines produced a myocarditis standardized morbidity ratio (SMR) greater than 1, with the CX-024414 vaccine having a greater SMR than TOZINAMERAN. The SMR for pericarditis was greater than 1 when considering the lowest background incidence, but smaller than 1 when considering the highest background incidence. Conclusions: Our results suggest an excess risk of myocarditis following the first dose of mRNA COVID-19 vaccine, but the relationship between pericarditis and mRNA COVID-19 vaccine remains unclear.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.27.22275706v1" target="_blank">A pharmacoepidemiological study of myocarditis and pericarditis following mRNA COVID-19 vaccination in Europe</a>
</div></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Association between Self-reported Masking Behavior and SARS-CoV-2 Infection Wanes from Pre-Delta to Omicron- Predominant Periods - North Carolina COVID-19 Community Research Partnership</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
We assessed the association between self-reported mask use during non-household interactions and COVID-19 infection during three pandemic periods. Odds of infection for those who did not always compared to those who always wore a mask was 66% higher during pre-Delta, 53% higher during Delta, declining to 16% higher during Omicron.
</p>
</div></li>
</ul>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.27.22275689v1" target="_blank">Association between Self-reported Masking Behavior and SARS-CoV-2 Infection Wanes from Pre-Delta to Omicron-Predominant Periods - North Carolina COVID-19 Community Research Partnership</a>
</div>
<ul>
<li><strong>CMV seropositivity in older adults changes T cell functionality, but does not prevent antibody or cellular SARS- CoV-2 vaccine responses</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It has been previously reported that chronic infection with human cytomegalovirus (CMV) may contribute to poor vaccine responses against de novo antigens in older adults. We assessed effects of CMV serostatus on antibody quantity and quality, as well as cellular memory responses, after 2 and 3 SARS-CoV-2 mRNA vaccine doses, in older adults in congregate living facilities. CMV serostatus did not affect anti-Spike and anti-RBD IgG antibody levels, nor neutralization capacity against wildtype or beta variants of SARS-CoV-2. CMV seropositivity altered T cell expression of senescence-associated markers and increased TEMRA cell numbers, as has been previously reported; however, this did not impact the Spike-specific CD4+ T cell memory responses. CMV seropositive individuals did not have a higher incidence of COVID-19, though prior infection influenced humoral immunity. Therefore, CMV seropositivity may alter T cell composition but does not impede humoral or cellular memory responses after SARS-CoV-2 mRNA vaccination in older adults.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.27.22275673v1" target="_blank">CMV seropositivity in older adults changes T cell functionality, but does not prevent antibody or cellular SARS-CoV-2 vaccine responses</a>
</div></li>
<li><strong>Immunogenicity and Safety of Beta Adjuvanted Recombinant Booster Vaccine</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background. Variant-adaptated vaccines against coronavirus disease 2019 (COVID-19) as boosters are needed to increase a broader protection against SARS CoV-2 variants. New adjuvanted recombinant protein vaccines as heterologous boosters could maximize the response. Methods. In this randomized, single-blinded, multicenter trial, adults who had received two doses of Pfizer-BioNTech mRNA vaccine (BNT162b2) 3 to7 months before were randomly assigned to receive a boost of BNT162b2, Sanofi/GSK SARS-CoV-2 adjuvanted recombinant protein MV D614 (monovalent parental formulation) or SARS-CoV-2 adjuvanted recombinant protein MV B.1.351 vaccine (monovalent Beta formulation). The primary endpoint was the percentage of subjects with a ≥ 10-fold increase in neutralizing antibody titers for the Wuhan (D614) and B.1.351 (Beta) SARS-CoV-2 viral strains between day 0 and day 15. Findings. The percentages of participants whose neutralizing antibody titers against the Wuhan (D614) SARS-CoV-2 strain increased by a factor ≥10 between day 0 and day 15 was 55.3% (95% CI 43.4-66.7) in MV D614 group (n=76), 76.1% (64.5-85.4) in MV B.1.351 (Beta) group (n=71) and 63.2% (51.3-73.9) in BNT162b2 group (n=76). These percentages were 44.7% (33.3-56.6), 84.5% (74.0-92.0) and 51.3% (39.6-63.0) for the B.1.351 (Beta) viral strain, respectively. Higher neutralizing antibodies rates against Delta and Omicron BA.1 variants were also elicited after Sanofi/GSK MV Beta vaccine compared to the other vaccines. Comparable reactogenicity profile was observed with the three vaccines. Interpretation. Heterologous boosting with the Sanofi/GSK Beta formulation vaccine resulted in a higher neutralizing antibody response against Beta variant but also the original strain and Delta and Omicron BA.1 variants, compared with mRNA BNT162b2 vaccine or the Sanofi/GSK MVD614 formulation. New vaccines containing Beta spike protein may represent an interesting strategy for broader protection against SARS CoV-2 variants.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.25.22274904v1" target="_blank">Immunogenicity and Safety of Beta Adjuvanted Recombinant Booster Vaccine</a>
</div></li>
<li><strong>A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Importance: While much of the attention on the COVID-19 pandemic was directed at the daily counts of cases and those with serious disease overwhelming health services, increasingly, reports have appeared of people who experience debilitating symptoms after the initial infection. This is popularly known as long COVID. Objective: To estimate by country and territory of the number of patients affected by long COVID in 2020 and 2021, the severity of their symptoms and expected pattern of recovery Design: We jointly analyzed ten ongoing cohort studies in ten countries for the occurrence of three major symptom clusters of long COVID among representative COVID cases. The defining symptoms of the three clusters (fatigue, cognitive problems, and shortness of breath) are explicitly mentioned in the WHO clinical case definition. For incidence of long COVID, we adopted the minimum duration after infection of three months from the WHO case definition. We pooled data from the contributing studies, two large medical record databases in the United States, and findings from 44 published studies using a Bayesian meta-regression tool. We separately estimated occurrence and pattern of recovery in patients with milder acute infections and those hospitalized. We estimated the incidence and prevalence of long COVID globally and by country in 2020 and 2021 as well as the severity-weighted prevalence using disability weights from the Global Burden of Disease study. Results: Analyses are based on detailed information for 1906 community infections and 10526 hospitalized patients from the ten collaborating cohorts, three of which included children. We added published data on 37262 community infections and 9540 hospitalized patients as well as ICD-coded medical record data concerning 1.3 million infections. Globally, in 2020 and 2021, 144.7 million (95% uncertainty interval [UI] 54.8-312.9) people suffered from any of the three symptom clusters of long COVID. This corresponds to 3.69% (1.38-7.96) of all infections. The fatigue, respiratory, and cognitive clusters occurred in 51.0% (16.9-92.4), 60.4% (18.9-89.1), and 35.4% (9.4-75.1) of long COVID cases, respectively. Those with milder acute COVID-19 cases had a quicker estimated recovery (median duration 3.99 months [IQR 3.84-4.20]) than those admitted for the acute infection (median duration 8.84 months [IQR 8.10-9.78]). At twelve months, 15.1% (10.3-21.1) continued to experience long COVID symptoms. Conclusions and relevance: The occurrence of debilitating ongoing symptoms of COVID-19 is common. Knowing how many people are affected, and for how long, is important to plan for rehabilitative services and support to return to social activities, places of learning, and the workplace when symptoms start to wane.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.26.22275532v1" target="_blank">A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021</a>
</div></li>
<li><strong>Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids</strong> -
<div>
While pluripotent stem cell-derived kidney organoids are now being used to model renal disease, the proximal nephron remains immature with limited evidence for key functional solute channels. This may reflect early mispatterning of the nephrogenic mesenchyme and/or insufficient maturation. Here we show that enhanced specification to metanephric nephron progenitors results in elongated and radially aligned proximalised nephrons with distinct S1 - S3 proximal tubule cell types. Such PT-enhanced organoids possess improved albumin and organic cation uptake, appropriate KIM-1 upregulation in response to cisplatin, and improved expression of SARS-CoV-2 entry factors resulting in increased viral replication. The striking proximo-distal orientation of nephrons resulted from localized WNT antagonism originating from the organoid stromal core. PT-enhanced organoids represent an improved model to study inherited and acquired proximal tubular disease as well as drug and viral responses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.10.14.464320v2" target="_blank">Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids</a>
</div></li>
<li><strong>Mapping the Perception-space of Facial Expressions in the Era of Face Masks</strong> -
<div>
With the advent of the SARS-CoV-2 pandemic, the theme of emotion recognition from facial expressions has become highly relevant due to the widespread use of face masks as one of the main devices imposed to counter the spread of the virus. Unsurprisingly, several studies published in the last two years have shown that accuracy in the recognition of basic emotions expressed by faces wearing masks is reduced. However, less is known about the impact that wearing face masks has on the ability to recognize emotions from subtle expressions. Furthermore, even less is known regarding the role of interindividual differences (such as alexithymic and autistic traits) in emotion processing. This study investigated the perception of all the six basic emotions (anger, disgust, fear, happiness, sadness, and surprise) both as a function of the face mask and as a function of the facial expressions’ intensity (full vs. subtle) in terms of participants’ uncertainty in their responses, misattribution errors and perceived intensity. The experiment was conducted online on a large sample of participants (N=129). Participants completed the 20-item Toronto Alexithymia Scale and the Autistic Spectrum Quotient and then performed an emotion-recognition task which involved face stimuli wearing a mask or not and displaying full or subtle expressions. Each face stimulus was presented alongside the Geneva Emotion Wheel (GEW) and participants had to indicate what emotion they believed the other person was feeling and its intensity by means of the GEW. For each combination of our variables, we computed the indices of ‘uncertainty’ (i.e., the spread of responses around the correct emotion category), ‘bias’ (i.e., the systematic errors in recognition) and ‘perceived intensity’ (i.e., the distance from the center of the GEW). We found that face masks increase uncertainty for all facial expressions of emotion, except for fear when intense, and that disgust was systematically confused with anger (i.e. response bias). Furthermore, when faces were covered by the mask, all the emotions were perceived as less intense, and this was particularly evident for subtle expressions. Finally, we did not find any evidence of a relationship between these indices and alexithymic/autistic traits.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/wp4k5/" target="_blank">Mapping the Perception-space of Facial Expressions in the Era of Face Masks</a>
</div></li>
<li><strong>Facing the Omicron variant - How well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic review</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The SARS-CoV-2 Omicron variant is currently the dominant variant globally. This 3rd interim analysis of a living systematic review summarizes evidence on COVID-19 vaccine effectiveness (VE) and duration of protection against Omicron. Methods: We systematically searched the COVID-19 literature for controlled studies evaluating the effectiveness of COVID-19 vaccines approved in the European Union up to 14/01/2022, complemented by hand-searches of websites and metasearch engines up to 11/02/2022. We considered the following comparisons: full primary immunization vs. no vaccination; booster immunization vs. no vaccination; booster vs. primary immunization. VE against any confirmed SARS-CoV-2 infection, symptomatic, and severe COVID-19 (i.e. COVID-19-related hospitalization, ICU-admission, or death) was indicated providing estimate ranges. Meta-analysis was not performed due to high study heterogeneity. Risk of bias was assessed with ROBINS-I, certainty of evidence evaluated using GRADE. Results: We identified 26 studies, including 430 to 2.2 million participants. VE against any confirmed SARS-CoV-2 infection compared to no vaccination ranged between 0-62% after full primary immunization, and between 34-66% after a booster dose. VE-range for booster vs. primary immunization was 34-54.6%. Against symptomatic COVID-19, VE ranged between 6-76% after full primary immunization, and between 19-73.9% after booster immunization, if compared to no vaccination. When comparing booster vs. primary immunization VE ranged between 56-69%. VE against severe COVID-19 compared to no vaccination ranged between 3-84% after full primary immunization, and between 12-100% after a booster dose. One study compared booster vs. primary immunization (VE 100%, 95% CI 71.4-100). VE was characterized by a moderate to strong decline within three to six months for SARS- CoV-2 infections and symptomatic COVID-19. Against severe COVID-19 protection remained robust at least for up to six months. Waning immunity was more profound after primary than booster immunization. Risk of bias was moderate to critical across studies and outcomes. GRADE-certainty was very low for all outcomes. Author9s conclusions: Under the Omicron variant, effectiveness of EU-licensed COVID-19 vaccines in preventing any SARS-CoV-2 infection or mild disease is low and only short-lasting after primary immunization, but can be improved by booster vaccination. VE against severe COVID-19 remains high and is long-lasting, especially after receiving the booster vaccination.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.25.22275516v1" target="_blank">Facing the Omicron variant - How well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic review</a>
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<li><strong>How is the COVID-19 pandemic impacting our life, mental health, and well-being? Design and preliminary findings of the pan-Canadian longitudinal COHESION Study</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Abstract With the advent of the COVID-19 pandemic, in-person social interactions and opportunities for accessing resources that sustain health and well-being have drastically reduced. We therefore designed the pan-Canadian population-based prospective COVID-19: HEalth and Social Inequities across Neighbourhoods (COHESION) cohort to provide deeper understanding of how the COVID-19 pandemic context affects mental health and well-being, key determinants of health, and health inequities. This paper presents the design of the two-phase COHESION Study, and descriptive results from the first phase conducted between May 2020 and September 2021. During that period, the COHESION research platform collected monthly data linked to COVID-19 such as infection and vaccination status, perceptions and attitudes regarding pandemic-related measures, and information on participants’ physical and mental health, well-being, sleep, loneliness, resilience, substances use, living conditions, social interactions, activities, and mobility. The 1,268 people enrolled in the Phase 1 COHESION Study are for the most part from Ontario (47%) and Quebec (33%), aged 48 ± 16 years [mean± standard deviation (SD)], and mainly women (78%), White (85%), with a university degree (63%), and living in large urban centers (70%). According to the 298 ± 68 (mean ± SD) prospective questionnaires completed each month in average, the first year of follow-up reveals significant temporal variations in standardized indexes of well-being, loneliness, anxiety, depression, and psychological distress. The COHESION Study will allow identifying trajectories of mental health and well-being while investigating their determinants and how these may vary by subgroup, over time, and across different provinces in Canada, in the unique context of the COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.26.22275645v1" target="_blank">How is the COVID-19 pandemic impacting our life, mental health, and well-being? Design and preliminary findings of the pan-Canadian longitudinal COHESION Study</a>
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<li><strong>Omicron reactive multi protein specific CD4 T cells defines cellular immune response induced by inactivated virus vaccines.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Unlike mRNA vaccines based only on the Spike protein, inactivated SARS-CoV-2 vaccines should induce a diversified T cell response recognizing distinct structural proteins. Here we performed a comparative analysis of SARS- CoV-2 specific T cells in healthy individuals following vaccination with inactivated SARS-CoV-2 or mRNA vaccines. Relative to Spike mRNA vaccination, inactivated vaccines elicited a lower magnitude of Spike-specific T cells, but the combined Membrane, Nucleoprotein and Spike specific T cell response was quantitatively comparable to the sole Spike T cell response induced by mRNA vaccines, and they efficiently tolerate the mutations characterizing the Omicron lineage. However, this multi-protein specific T cell response was not mediated by a coordinated CD4 and CD8 T cell expansion but by selected priming of CD4 T cells. These findings can help in defining the role of CD4 and CD8 T cells in the efficacy of the different vaccines to control severe COVID-19 after Omicron infection.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.25.22275616v1" target="_blank">Omicron reactive multi protein specific CD4 T cells defines cellular immune response induced by inactivated virus vaccines.</a>
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<li><strong>Covid-19 is a leading cause of death in children and young people ages 0-19 years in the United States</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Covid-19 has caused more than 1 million deaths in the US, including at least 1,433 deaths among children and young people (CYP) aged 0-19 years. Deaths among US CYP are rare in general, and so we argue here that the mortality burden of Covid-19 in CYP is best understood in the context of all other causes of CYP death. Using publicly available data from the National Center for Health Statistics, and comparing to mortality in 2019, the immediate pre-pandemic period, we find that Covid-19 is a leading cause of death in CYP aged 0-19 years in the US, ranking #9 among all causes of deaths, #5 in disease related causes of deaths (excluding accidents, assault and suicide), and #1 in deaths caused by infectious / respiratory diseases. Due to the impact of mitigations such as social distancing and our comparison of a single disease (Covid-19) to groups of causes such as deaths from pneumonia and influenza, these rankings are likely conservative lower bounds. Our findings underscore the importance of continued vaccination campaigns for CYP over 5 years of age in the US and for effective Covid-19 vaccines for under 5 year olds.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.23.22275458v2" target="_blank">Covid-19 is a leading cause of death in children and young people ages 0-19 years in the United States</a>
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<li><strong>Infectiousness in omicron variant strain and bA.2 variant in Japan</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Omicron variant strain dominated since the beginning of 2022. Its infectivity was supposes to be higher than Delta variant strain or strains in past. Object: We estimated prevalence of omicron variant strain, particularly bA.2 variant and COVID-19 vaccine effectiveness of the third dose in Japan as well as controlling for waning of second dose of vaccine, other mutated strains, the Olympic Games, and countermeasures. Method: The effective reproduction number R(t) was regressed on shares of omicron variant strain and bA.2 and vaccine coverage of the third dose, as well as along with data of temperature, humidity, mobility, share of the other mutated strains, and an Olympic Games and countermeasures. The study period was February, 2020 through February 21, 2022, as of March 15, 2022. Results : Estimation results indicated that waning of the second dose vaccine e with 150 days prior was the most appropriate specification. Moreover, bA.2 of omicron variant strain has higher infectively than other variant strain or traditional strain. Discussion: Because of data limitation since emerging bA.2, the estimated its infectively will change over time.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.20.21259209v7" target="_blank">Infectiousness in omicron variant strain and bA.2 variant in Japan</a>
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<li><strong>Epidemiological Interactions of Influenza and SARS-CoV-2 within a University Population During Omicron B.1.1.529 Outbreak</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The COVID-19 Pandemic has prompted innovation and research to further understand not only SARS-CoV-2, but other respiratory viruses as well. Since the start of the pandemic there has been a lack in influenza collection and surveillance. In October 2021 the Life Sciences Testing Center at Northeastern University implemented the TaqPath™ COVID-19, Flu A, Flu B combo kit to test for multiple respiratory diseases among the University’s population. During this time the SARS- CoV-2 variant of concern, Omicron B.1.1.529, became the dominant strain in the greater Boston area. During this time an inverse correlation in the detection of positive SARS-CoV-2 and Influenza A was observed. More data is needed to determine if this observed inverse correlation on positivity rate is linked to public health measures or biological mechanism within the immune system.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.26.22275641v1" target="_blank">Epidemiological Interactions of Influenza and SARS-CoV-2 within a University Population During Omicron B.1.1.529 Outbreak</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Safety and Efficacy Study of Hymecromone Tablets for the Treatment of Patients With COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Hymecromone tablets;   Other: Placebo<br/><b>Sponsor</b>:   Shanghai Zhongshan Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on Sequential Immunization of Omicron Inactivated COVID-19 Vaccine and Prototype Inactivated COVID-19 Vaccine in Population Aged 18 Years Old and Above</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Omicron COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: COVID-19 Vaccine (Vero Cell), Inactivated<br/><b>Sponsors</b>:  <br/>
China National Biotec Group Company Limited;   Beijing Institute of Biological Products Co Ltd.;   Hunan Provincial Center for Disease Control and Prevention<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase Ia, Dose-finding Study to Assess the Safety and Immunogenicity of a COVID-19 Vaccine Booster in Healthy Adults</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Prime-2-CoV_Beta<br/><b>Sponsors</b>:  <br/>
University Hospital Tuebingen;   FGK Clinical Research GmbH;   VisMederi srl;   Staburo GmbH;   Viedoc Technologies AB<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Learn About the Study Medicine (Called Nirmatrelvir/Ritonavir) in Pregnant Women With Mild or Moderate COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: nirmatrelvir;   Drug: ritonavir<br/><b>Sponsor</b>:   Pfizer<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of COVID-19 Vaccines Given as a Booster in Healthy Adults in Indonesia (MIACoV Indonesia)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Pfizer-BioNTech Standard dose;   Biological: AstraZeneca Standard dose;   Biological: Pfizer-BioNTech Fractional dose;   Biological: AstraZeneca Fractional dose;   Biological: Moderna Standard dose;   Biological: Moderna Fractional dose<br/><b>Sponsors</b>:   Murdoch Childrens Research Institute;   Universitas Padjadjaran (UNPAD);   Universitas Indonesia (UI);   Health Development Policy Agency, Ministry of Health Republic of Indonesia;   Coalition for Epidemic Preparedness Innovations;   The Peter Doherty Institute for Infection and Immunity<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Efficacy and Safety of DXP604 in Patients With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: DXP604<br/><b>Sponsor</b>:  <br/>
Wuhan Institute of Biological Products Co., Ltd<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sequential Immunization of Two Doses of Inactivated COVID-19 Vaccine (Omicron) in Vaccinated Population Aged 18 Years and Above</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: BIBP Omicron Inactivated COVID-19 vaccine (Vero Cell);   Biological: WIBP Omicron Inactivated COVID-19 vaccine (Vero Cell);   Biological: COVID-19 Vaccine (Vero Cell), Inactivated<br/><b>Sponsors</b>:   China National Biotec Group Company Limited;   Beijing Institute of Biological Products Co Ltd.;   Wuhan Institute of Biological Products Co., Ltd;   The University of Hong Kong<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety of Booster Immunization of COVID-19 Vaccine (Vero Cell), Inactivated (Omicron Variant) in Healthy People Aged 18 Years and Above</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVID-19 Vaccine (Vero cell), Inactivated (Omicron variant);   Biological: COVID-19 Vaccine (Vero cell), Inactivated (CZ strain)<br/><b>Sponsor</b>:  <br/>
Sinovac Research and Development Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Randomized, Open-label, Dose-ranging Study in Adults and Pediatric Individuals ≥ 12 Years of Age to Assess the Safety, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AZD7442, for Pre-exposure Prophylaxis of COVID-19</strong> - <b>Condition</b>:   Coronavirus Disease 2019 (COVID-19)<br/><b>Intervention</b>:   Biological: AZD7442 (tixagevimab [AZD8895] + cilgavimab [AZD1061])<br/><b>Sponsor</b>:   AstraZeneca<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhaled Interferon α2b Treatment in Mild-to-moderate COVID-19 Infected Children</strong> - <b>Conditions</b>:   COVID-19;   Children<br/><b>Interventions</b>:   Drug: Inhaled Interferon α2b;   Other: Standard of Care<br/><b>Sponsors</b>:   Children’s Hospital of Fudan University;   RenJi Hospital;   Shanghai Children’s Hospital;   Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>INTEGrating Ag-RDTs for COVID in MNCH,HIV and TB Services in Cameroon and Kenya:A Cluster Randomized Trial of Two Models</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Diagnostic Test: Test all<br/><b>Sponsors</b>:  <br/>
Elizabeth Glaser Pediatric AIDS Foundation;   UNITAID;   Kenya Ministry of Health;   Ministry of Public Health, Cameroon<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pulmonary Rehabilitation Program With Pulsed Electromagnetic Field Therapy in Patients With Post-covid Sequelae.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Device: Pulsed ectromagnetid field therapy;   Other: Pulmonary rehabilitation program (PRP)<br/><b>Sponsor</b>:   University of Malaga<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Paxlovid in the Treatment of COVID-19 Patients With Uremia</strong> - <b>Conditions</b>:   COVID-19;   Uremia<br/><b>Interventions</b>:   Drug: Paxlovid;   Drug: standard-of-care<br/><b>Sponsor</b>:   Ruijin Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Telemedically Assisted Sampling of COVID-19 Patients - Is the Sampling Quality Sufficient</strong> - <b>Conditions</b>:   Telemedicine;   Pharynx;   COVID-19<br/><b>Intervention</b>:   Diagnostic Test: telemedically guided oropharyngeal + nasal (OP+N) self-sampling (GSS) and nasopharyngeal (NP) or OP+N sampling performed by health care professionals (HCP)<br/><b>Sponsor</b>:   Teststation Praxis Dr. med Bielecki<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Improving Pediatric COVID-19 Vaccine Uptake Using an mHealth Tool</strong> - <b>Conditions</b>:   COVID-19 Vaccines;   Telemedicine;   Vaccine Hesitancy;   Pediatric ALL<br/><b>Interventions</b>:   Behavioral: COVID-19 Vaccine Uptake App;   Other: General Health App<br/><b>Sponsors</b>:  <br/>
University of Arkansas;   National Institutes of Health (NIH);   University of Nebraska;   University of Montana<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Retraction: Jiang, H.; Mei, Y.-F. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. <em>Viruses</em> 2021, <em>13</em>, 2056</strong> - The published article […].</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor</strong> - Lipids play a crucial role in the entry and egress of viruses, regardless of whether they are naked or enveloped. Recent evidence shows that lipid involvement in viral infection goes much further. During replication, many viruses rearrange internal lipid membranes to create niches where they replicate and assemble. Because of the close connection between lipids and inflammation, the derangement of lipid metabolism also results in the production of inflammatory stimuli. Due to its pivotal…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Infectious Bronchitis Virus Nsp14 Degrades JAK1 to Inhibit the JAK-STAT Signaling Pathway in HD11 Cells</strong> - Coronaviruses (CoVs) are RNA viruses that can infect a wide range of animals, including humans, and cause severe respiratory and gastrointestinal disease. The Gammacoronavirus avian infectious bronchitis virus (IBV) causes acute and contagious diseases in chickens, leading to severe economic losses. Nonstructural protein 14 (Nsp14) is a nonstructural protein encoded by the CoV genome. This protein has a regulatory role in viral virulence and replication. However, the function and mechanism of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions</strong> - This paper presents a molecular characterization of the interaction between the SARS-CoV-2 envelope (E) protein and TLR2. We demonstrated that the E protein, both as a recombinant soluble protein and as a native membrane protein associated with SARS-CoV-2 viral particles, interacts physically with the TLR2 receptor in a specific and dose-dependent manner. Furthermore, we showed that the specific interaction with the TLR2 pathway activates the NF-κB transcription factor and stimulates the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Unique Robust Dual-Promoter-Driven and Dual-Reporter-Expressing SARS-CoV-2 Replicon: Construction and Characterization</strong> - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, SARS2) remains a great global health threat and demands identification of more effective and SARS2-targeted antiviral drugs, even with successful development of anti-SARS2 vaccines. Viral replicons have proven to be a rapid, safe, and readily scalable platform for high-throughput screening, identification, and evaluation of antiviral drugs against positive-stranded RNA viruses. In the study, we report a unique robust HIV long…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comparison of Six Serological Immunoassays for the Detection of SARS-CoV-2 Neutralizing Antibody Levels in the Vaccinated Population</strong> - Neutralizing antibody (NAb) detection is critical for evaluating herd immunity and monitoring the efficacy of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, quantitative SARS-CoV-2 antibody levels after vaccination were measured by chemiluminescent immunoassays, enzyme immunoassays, and surrogate virus neutralization tests (sVNTs), as well as plaque reduction neutralization tests (PRNT). Sequential blood samples were collected before and 1 and 3…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses</strong> - New strategies to rapidly develop broad-spectrum antiviral therapies are urgently required for emerging and re-emerging viruses. Host-targeting antivirals (HTAs) that target the universal host factors necessary for viral replication are the most promising approach, with broad-spectrum, foresighted function, and low resistance. We and others recently identified that host dihydroorotate dehydrogenase (DHODH) is one of the universal host factors essential for the replication of many…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication</strong> - RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are dependent on host genes for replication. We investigated if probenecid, an FDA-approved and safe urate-lowering drug that inhibits organic anion transporters (OATs) has prophylactic or therapeutic efficacy to inhibit RSV replication in three epithelial cell lines used in RSV studies, i.e., Vero E6 cells, HEp-2 cells, and in primary normal human bronchoepithelial (NHBE) cells, and in BALB/c mice. The studies…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting of Silver Cations, Silver-Cystine Complexes, Ag Nanoclusters, and Nanoparticles towards SARS-CoV-2 RNA and Recombinant Virion Proteins</strong> - Background: Nanosilver possesses antiviral, antibacterial, anti-inflammatory, anti-angiogenesis, antiplatelet, and anticancer properties. The development of disinfectants, inactivated vaccines, and combined etiotropic and immunomodulation therapy against respiratory viral infections, including COVID-19, remains urgent. Aim: Our goal was to determine the SARS-CoV-2 molecular targets (genomic RNA and the structural virion proteins S and N) for silver- containing nanomaterials. Methods: SARS-CoV-2…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Montelukast Inhibits HCoV-OC43 Infection as a Viral Inactivator</strong> - Coronaviruses (CoVs) consist of a large group of RNA viruses causing various diseases in humans and in lots of animals. Human coronavirus (HCoV) OC43, the prototype of beta-coronavirus discovered in the 1960s, has been circulating in humans for long time, and infection with other emerging strains of beta-coronavirus (SARS-CoV, SARS-CoV-2, and MERS-CoV) can lead to severe illness and death. In this study, we found that montelukast, a leukotriene receptor antagonist, potently inhibited the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antimicrobial Biomaterial on Sutures, Bandages and Face Masks with Potential for Infection Control</strong> - Antimicrobial resistance (AMR) is a challenge for the survival of the human race. The steady rise of resistant microorganisms against the common antimicrobials results in increased morbidity and mortality rates. Iodine and a plethora of plant secondary metabolites inhibit microbial proliferation. Antiseptic iodophors and many phytochemicals are unaffected by AMR. Surgical site and wound infections can be prevented or treated by utilizing such compounds on sutures and bandages. Coating surgical…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inclusion of a Phytomedicinal Flavonoid in Biocompatible Surface-Modified Chylomicron Mimic Nanovesicles with Improved Oral Bioavailability and Virucidal Activity: Molecular Modeling and Pharmacodynamic Studies</strong> - Morin hydrate (MH) is a widely-used Asian phytomedicinal flavonoid with a wide range of reported therapeutic activities. However, MH has limited oral bioavailability due to its low aqueous solubility and intestinal permeability, which in turn hinders its potential antiviral activity. The study reported herein was designed to encapsulate MH in polyethyleneglycolated (PEGylated) chylomicrons (PCMs) and to boost its antiviral activity and biological availability for oral administration using a rat…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Methylene Blue Is a Nonspecific Protein-Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19</strong> - We have previously identified methylene blue, a tricyclic phenothiazine dye approved for clinical use for the treatment of methemoglobinemia and for other medical applications as a small-molecule inhibitor of the protein-protein interaction (PPI) between the spike protein of the SARS-CoV-2 coronavirus and ACE2, the first critical step of the attachment and entry of this coronavirus responsible for the COVID-19 pandemic. Here, we show that methylene blue concentration dependently inhibits this…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of Human Respiratory Influenza A Virus and Human Betacoronavirus-1 by the Blend of Double-Standardized Extracts of <em>Aronia melanocarpa</em> (Michx.) Elliot and <em>Sambucus nigra</em> L</strong> - Viral and bacterial diseases are among the greatest concerns of humankind since ancient times. Despite tremendous pharmacological progress, there is still a need to search for new drugs that could treat or support the healing processes. A rich source of bioactive compounds with antiviral potency include plants such as black chokeberry and elderberry. The aim of this study was to assess the in vitro antiviral ability of an originally designed double- standardized blend of extracts from Aronia…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Integrin/TGF-β1 Inhibitor GLPG-0187 Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which Could Attenuate Disease Severity</strong> - As COVID-19 continues to pose major risk for vulnerable populations, including the elderly, immunocompromised, patients with cancer, and those with contraindications to vaccination, novel treatment strategies are urgently needed. SARS-CoV-2 infects target cells via RGD-binding integrins, either independently or as a co-receptor with surface receptor angiotensin-converting enzyme 2 (ACE2). We used pan-integrin inhibitor GLPG-0187 to demonstrate the blockade of SARS- CoV-2 pseudovirus infection of…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How to Prevent Gun Massacres? Look Around the World</strong> - Australia, Britain, Canada, and other countries have enacted reforms that turned mass shootings into rare, aberrational events rather than everyday occurrences. - <a href="https://www.newyorker.com/news/our-columnists/how-to-prevent-gun-massacres-look-around-the-world">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Will an Emergency Law Used to Keep Out Migrants Become Permanent?</strong> - At the start of the pandemic, the Trump Administration invoked an obscure provision called Title 42 to effectively stop migration. Even as other COVID restrictions are lifted, anti-immigration politicians insist that it remain in place. - <a href="https://www.newyorker.com/news/letter-from-the-southwest/will-an-emergency-law-used-to-keep-out-migrants-%20become-permanent">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>America’s Redistricting Process Is Breaking Democracy</strong> - Democrats have tried to keep up with Republican gerrymandering—and everyone is losing. - <a href="https://www.newyorker.com/news/the-political-scene/americas-redistricting-process-is-breaking-democracy">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Staff of Uvalde’s Local Paper Cover the Worst Day of Their Lives</strong> - The paper’s employees lost neighbors, acquaintances, and a daughter in a school shooting. Then they had to report the story. - <a href="https://www.newyorker.com/news/letter-from-the-southwest/the-staff-of-uvaldes-local-paper-cover-the-worst-day-%20of-their-lives">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Baby-Formula Blame Game</strong> - At a House committee hearing this week, the F.D.A. and Abbott passed the buck. With parents scrambling to feed their children, who’s responsible for the shortages? - <a href="https://www.newyorker.com/news/daily-comment/the-baby-formula-blame-game">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The increase in US births in 2021, explained</strong> -
<figure>
<img alt="" src="https://cdn.vox-
cdn.com/thumbor/ZF_H24E5fzL2eiT3yfmj_sM0Hn8=/136x0:5469x4000/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70921994/GettyImages_1307193814.0.jpg"/>
<figcaption>
A newborn baby with mother. | Getty Images/Cavan Images RF
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Births went up by 1 percent last year, but don’t think of it as a baby boom.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x3biLj">
A total of 3,659,289 babies were born in the US in 2021, according to new data <a href="https://www.cdc.gov/nchs/data/vsrr/vsrr020.pdf">released this week</a> by the CDC’s National Center for Health Statistics. That’s 1 percent more than the 3,613,647 babies born in the US in 2020, which means that the natal class of 2021 is now what passes for a baby boom in the United States of America.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1b6Ss5">
Indeed, 2021 represents the <a href="https://www.axios.com/2022/05/24/us-birth-rate-increases">first time since 2014</a> that the number of babies born in the US actually increased, bouncing back from a pandemic year in 2020 that saw the <a href="https://apnews.com/article/birth-rates-science-coronavirus-pandemic-
health-d51571bda4aa02eafdd42265912f1202">largest one-year drop</a> in births in nearly 50 years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qdX0cz">
The 2020 dip in births wasn’t much of a surprise to demographers. Despite the <a href="https://www.nytimes.com/2020/04/08/us/coronavirus-baby-boom.html">popular misconception</a> that events like blizzards and blackouts that keep couples homebound inevitably lead to more babies nine months later, the lockdowns of early 2020 were not particularly conducive to the conceiving of children. Surveys conducted during 2020 found that as many <a href="https://www.guttmacher.org/report/early-impacts-covid-19-pandemic-findings-2020-guttmacher-survey-
reproductive-health">as a third of American women</a> changed their reproductive plans because of the pandemic, while and as many as <a href="https://www.tandfonline.com/doi/full/10.1080/01490400.2020.1774016">half of American adults</a> reported a decline in their sexual activity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A6yXLi">
That 1 percent increase in births in 2021 stems in part from planned pregnancies delayed for a year or so, until the country saw improved epidemiological and economic conditions during the later stages of the pandemic, as <a href="https://www.nytimes.com/2022/05/24/us/birth-rate-
increase.html">stimulus and unemployment aid</a> from the government made would-be parents a little less apprehensive about bringing a new life into the world.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ElMvCZ">
So the playgrounds and preschools might be a smidge more crowded over the next few years. But make no mistake: This is not a baby boom that is meant to last.
</p>
<h3 id="bQGMxx">
<strong>A momentary bump amid a long-term decline?</strong>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UO90mh">
Despite the 2021 bump, there were fewer babies born last year than in 2019 before the pandemic. Both the total number of births and the birth rate in the US have<strong> </strong>been on a general decline since 2007, when 4,316,233 members of Gen Z <a href="https://www.cdc.gov/nchs/data/nvsr/nvsr58/nvsr58_24.pdf">entered the world</a>, the highest single number in US history.
</p>
<div id="TBoQ98">
</div></li>
<li><strong>Underground hip-hop is banned in Egypt. Now, it’s the soundtrack to Marvel’s Moon Knight.</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/bPVQK-
Xe87W1IDtvPoNa05pfA-0=/46x0:2187x1606/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70921926/fhm1031_106_comp_wta_v0106_76d40e3c.0.jpeg"/>
<figcaption>
Oscar Isaac as Mr. Knight in Marvel Studios’ <em>Moon Knight</em>, exclusively on Disney+. | Courtesy of Marvel Studios
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Disney+ show is scored by subversive Egyptian rap of the Arab Spring.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3X695e">
The soundscape transports you. The sharp electronic snare beats and deep bass rumble, with samples and autotuned lyrics in street slang, taking you to Cairo at night, floating down the Nile on a party boat with dangling neon lights and a tinny speaker. It’s loud.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mfgWa3">
This genre of underground Egyptian rap is called mahraganat, and it elevates the <a href="https://english.alaraby.co.uk/features/how-egypts-mahraganat-music-marvels-
disneys-moon-knight">soundtrack</a> of the new Marvel series <em>Moon Knight</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MNwOxB">
Egyptian director Mohamed Diab has brought the controversial sound to the show, which stars Oscar Isaac as, among other roles, an antihero who struggles with <a href="https://www.polygon.com/23000498/moon-knight-marvel-comics-origin-powers-
personalities">mental health issues</a>. (He is also the living avatar of an ancient Egyptian god.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q1vW3i">
Even though the Disney+ show was shot elsewhere and its topic was fantastical, the filmmaker behind <a href="https://www.imdb.com/title/tt1764141/"><em>Cairo 678</em></a> wanted to show the reality of his country. “One challenge that was very important for me was how to portray Egypt,” <a href="https://podcasts.apple.com/us/podcast/moon-
knight-directors-mohamed-diab-justin-benson-aaron/id715084602?i=1000555723025">said</a> Diab, “because we’re always seen in a way that is very orientalist, always seen in a way that is very stereotypical.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g2QTn9">
In the third episode, a breezy Egyptian pop song wafts down the Nile and then cuts to a blaring mahraganat track, which starts a group of boaters dancing. The song is by Hassan Shakosh, who is <a href="https://egyptindependent.com/hassan-shakoush-
appeals-to-lift-license-suspension-after-trading-jibes-with-reda-al-bahrawy/">censored</a> in Egypt.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-
cdn.com/thumbor/atUSvivGjOPzWGmybFnBQIEll5w=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23592339/1155983053.jpg"/> <cite><a class="ql-link" href="https://www.gettyimages.com/search/photographer?photographer=NurPhoto" target="_blank">NurPhoto</a> / Contributor</cite>
<figcaption>
Lighted boats at night on the river Nile, Cairo, Egypt, on July 12, 2019.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nVzYU1">
Shakosh precipitated a country-wide assault on the music. Two days after he <a href="https://egyptianstreets.com/2020/02/17/popular-mahraganat-music-is-now-banned-
according-to-egypts-musical-syndicate/">performed</a> raunchy songs at a Valentine’s Day show at Cairo Stadium in 2020, the Egyptian Musicians Syndicate, the body that licenses all musicians in the country, <a href="https://www.al-
monitor.com/originals/2020/02/egypt-bans-street-music-singers-following-controversy-over.html">banned</a> mahraganat performances. Yet through online streaming and digital distribution, Shakosh has become a superstar.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ERKUn3">
For the musicians in Egypt taking rap in new directions, <em>Moon Knight</em> is a mainstream breakthrough, a chance for international audiences to understand a little more about the country. The underground genre has become a battleground in a country headed by an <a href="https://www.nytimes.com/2020/12/07/opinion/biden-egypt-human-
rights.html">autocratic president</a> who has repressed all discursive politics. The regime has targeted <a href="https://prospect.org/world/new-generation-dies-egypt-prison-shady-habash/">young creatives</a> and <a href="https://www.codastory.com/authoritarian-tech/egypt-cybercrime-bill/">TikTok influencers</a>, so the spotlight on mahraganat matters.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eHPtrr">
Mahraganat “reveals a struggle over what Egyptian culture is, and who has the right to shape it,” Andrew Simon, a historian at Dartmouth, told me. Its appearance in <em>Moon Knight</em> “is all much to the dismay of Egyptian authorities at a point in time when they’re actively trying to silence the genre.”
</p>
<h3 id="ynfFfv">
Mahgaranat music came before the Arab Spring, and the insurrection took it viral
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="opPGMC">
The underground rap subgenre’s journey from Egypt’s urban corners into the Marvel Cinematic Universe begins in the early 2000s. At weddings in the back alleys of Egypt’s working-class landscape, emcees and deejays pioneered mahraganat, which means “festivals” in Arabic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f5ztZE">
Weddings in city quarters are indeed street festivals. Raucous block parties take over whole backstreets, and everyone in the neighborhood is welcome. Traditionally, an ensemble would play music called <a href="http://www.aswandancers.org/shaabi-history">shaabi</a> (or “popular,” as in, “of the people”), which blends folkloric sounds, spiritual tunes associated with Sufism, and Egyptian pop traditions — and a lot of drumming and heavy dancing. But a full band can be expensive, so deejays and emcees started tooling around with MP3s and cheap software, passing around files in internet cafes. They brought an electronica sentiment to traditional shaabi sounds, soon adding layers of raps and chants on top.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZwGf2V">
Those emcees hyping up the wedding crowds, and collecting some money for the newlyweds, forged a new genre. Then they started circulating it on mixtapes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P4yQh8">
“All these nerds behind their computers doing these strange loops” created a new musical vocabulary, Mahmoud Refat, founder of the <a href="https://www.youtube.com/channel/UCiWiOchXTUmmtGlQN06jMkg/featured">100Copies</a> label in Cairo, told me. “They used samples of these guys talking about the struggle, weddings, drugs, you know, like the tough life.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K1iFXo">
The song that blares on <em>Moon Knight</em>’s Nile boat is “<a href="https://www.youtube.com/watch?v=n_cibhQu8HI">Salka</a>,” which translates roughly as “unobstructed.” The scene gestures toward mahraganat’s roots in the city’s alleys. “I haven’t heard that song since our wedding,” says the former mercenary Marc Spector (Isaac) to his archaeologist compatriot (May Calamawy).
</p>
<figure class="e-image"></figure></li>
</ul>
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/S5dQRRqTLNR3M0pz54xZbTmnmv8=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23592285/hsk_103_22211_r_eaef58d4.jpeg"/> <cite>Gabor Kotschy/Marvel Studios 2022</cite>
<figcaption>
May Calamawy as Layla El-Faouly and Oscar Isaac as Marc Spector/Steven Grant in Marvel Studios’ <em>Moon Knight</em>.
</figcaption>
<div id="rpeUmc">
<div style="width: 100%; height: 0; padding-
bottom: 56.25%;">
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZzJD5c">
The lyrics are about a Ferrari speeding through the usually standstill traffic of Cairo’s megalopolis: “Strong, nobody but us / Strong, strong / Sweet, nobody but us / Sweet, sweet / Foot the gas on the highest gear / I’m the teacher and everybody’s at their desk / Unobstructed.” (The song appeared in an Egyptian <a href="https://m.facebook.com/FbRapMusic/videos/1409605852726590/?refsrc=deprecated&amp;_rdr">advertisement</a> for an app called Hala, which is like Uber but for motorcycles.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AVp8ne">
Tarek Benchouia, a PhD candidate at Northwestern University who studies mahraganat, describes it as a complex, ever-changing form that has integrated aspects of rap and hip-hop, Jamaican dancehall, and local traditions. “It’s a very similar story to the story of hip- hop,” he told me. “Because that’s where hip-hop comes from, in the Bronx in the ’70s. It’s a deejaying culture that’s playing block parties. So it’s interesting how they have similar genealogies but they sound very different.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7qI8WB">
During Egypt’s 2011 people-power revolution that ousted longtime dictator Hosni Mubarak, mahraganat became a sonic companion to the uprising — music that captured the angst and anger at the crippling economic circumstances that fomented the youth movement. Many in the international media mistakenly described it as music of the revolution because mahraganat’s popularity <a href="https://www.nytimes.com/2013/05/12/world/middleeast/egypts-chaos-stirs-musical-
revolution.html">accelerated</a> so rapidly after 2011. “[T]he insurrection had made many people more willing to listen to what was novel, full of youthful energy, and ‘street,’” anthropologist Ted Swedenburg <a href="https://www.jstor.org/stable/j.ctv14h4pr?turn_away=true">notes</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OItH0r">
Benchouia says the music’s undertones are of a piece with the revolution. “It’s nuanced in its critique of what it means to be poor and, usually, male in urban Egypt. A lot of the anger and frustration that boils over in the revolution is also being explained in mahraganat,” he told me.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="j9aqgT">
But irreverence and self-effacement are key. “There’s a little bit of poking fun at the revolution at the same time,” said Benchouia, and some mahraganat songs <a href="https://egyptrevolution2011.ac.uk/items/show/228">played off</a> of popular chants from the Tahrir Square protests. There’s a line in “Salka” that goes, “We made the music / we’re not copying it [from the West] / We don’t make it better than it is / Or make a big deal of it.” The anti-establishment rhythms of mahraganat spread on the sound systems of <a href="https://www.egypttoday.com/Article/1/60673/Toktok-Egypt-s-14-year-controversy">toktoks</a>, <a href="https://www.madamasr.com/en/topic/microbus/">microbuses</a>, and eventually taxis, in urban centers and on the margins of Egyptian official culture.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Fhh3TR">
In 2013, the military overthrew Egypt’s <a href="https://prospect.org/world/mohamed-morsi-postscript/">first democratically elected leader</a>. Former Gen. Abdel- Fattah Al-Sisi now runs the country more brutally than Mubarak ever did. Amid a <a href="https://www.amnesty.org/en/latest/news/2018/09/egypt-unprecedented-crackdown-on-freedom-of-expression-under-
alsisi-turns-egypt-into-openair-prison/">clampdown on political expression</a>, mahraganat music has become even more popular. Hit songs are being DIY-recorded in rappers’ wardrobes and bedrooms. Tens of millions of plays on YouTube and Spotify hold out a challenge to the regime’s traditional, nationalistic music tastes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TC4gD4">
Mahraganat’s founding artists have established themselves in and out of Egypt. In 2018, two key figures, Sadat and Alaa 50 Cent, <a href="https://www.youtube.com/watch?v=buxccDwjkdA">collaborated with Cypress Hill</a> in a song that blended the California group’s connection to weed culture with the Egyptian rappers’ passion for hashish.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I5HVwY">
Much of mahraganat music is not overtly political in the sense of it being about rising up against the regime or protesting policies, but it is deeply political in the grievances expressed about the economic and social conditions that hamper Egypt’s working classes. The lyrics are also introspective — verging from macho to campy — about masculinity and authenticity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NEILxr">
The gritty brand of rap captures the fraught politics of disenchantment, youth culture, and dissatisfaction with the lack of opportunity that sets the backdrop to the Marvel series. In <em>Moon Knight</em>’s Cairo scenes, the street sellers seem to be just getting by and youngsters appear to be out of work.
</p>
<div id="ByAAyc">
<div style="width: 100%; height: 0; padding-bottom: 56.25%;">
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5DDCdp">
The credits of <em>Moon Knight</em>’s second episode feature the song “<a href="https://www.youtube.com/watch?v=4_vtOKcfCG8">The Kings</a>,” by Ahmed Saad along with two mahgaranat singers, 3enba and Yang Zuksh. It’s more of a rap hybrid, which is the direction the genre is headed. The chorus sums up the gangland vibes that are performatively flexed by the underground singers and shouting out their neighborhood, surrounded by their crew: “Bro / Papa / Here comes the gang / We live / Simply / You can make it if you want to / I don’t need anyone / I take care of myself.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GHy1sH">
In the next episode, Oscar Isaac wakes up in Cairo.
</p>
<h3 id="sucGSW">
What the censorship of Mahraganat — and its presence in <em>Moon Knight</em> — says about Egypt
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8H78d7">
The brash sensibility of mahraganat has long challenged the Egyptian Musicians Syndicate. The gatekeeping professional organization holds the power to grant the licenses needed for musicians to perform at concerts, nightclubs, and even restaurants in the country. The syndicate is backed by the Sisi government and, some say, has become a proxy for the culture war against Egypt’s young rappers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tf2XFl">
In February 2020, the syndicate announced that licenses to perform would no longer be given to mahraganat artists, effectively banning it from live shows. “This type of music is based on promiscuous and immoral lyrics, which is completely prohibited, and as such, the door is closed on it. We want real art,” singer Hany Shaker, the syndicate’s head, <a href="https://www.middleeasteye.net/news/egypt-musical-syndicate-bans-popular-mahraganat-genre-music">said</a>. A parliamentary spokesperson <a href="https://www.middleeastmonitor.com/20200218-mahraganat-music-more-dangerous-than-
coronavirus-says-egypt-parliament-spokesman/">called</a> mahraganat more dangerous than Covid-19.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2Hbgu4">
“Most of the songs that Diab used in this show are from singers banned from singing in Egypt,” novelist and critic Ahmed Naji told me. “It created a lot of controversy and created a huge buzz.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NttHHz">
At least <a href="https://www.nytimes.com/2022/01/16/world/middleeast/egypt-mahraganat-music.html">19 musicians</a> were denied licenses in 2021, including Shakosh. Saad, whose hit song “Kings” is in <em>Moon Knight</em>, was <a href="https://www.thenationalnews.com/arts-culture/music/2021/11/04/hany-shaker-on-mahraganat-music-because-its-popular-
on-youtube-doesnt-make-it-good/">fined</a> for defying the ban. In March, two other singers were <a href="https://www.hrw.org/news/2022/04/27/egypt-two-singers-convicted-morality-charges">convicted</a> of “violating family values.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DqRb1z">
But mahraganat artists work around the rules and post straight to Spotify or YouTube, onto algorithms that put them alongside Kendrick Lamar and Lil Wayne, or hold shows in Egypt’s unofficial venues. They play gigs around the Middle East, and are developing partnerships with American and European artists. “We are having investors coming directly to us. We are having Hollywood coming directly to us. We have Sony Music,” Rafat told me. “But it doesn’t link to the Egyptian scene. It doesn’t link to the Egyptian music economy.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fFJcv5">
For Simon, author of a book on Egyptian sonic cultures called <a href="https://www.sup.org/books/title/?id=31649"><em>Media of the Masses</em></a>, the fault lines are not just about free expression but about class. The censorship of mahraganat is about who in Egypt — with hierarchies enforced by the regime — is allowed to create art. “These ‘vulgar’ songs, what’s really the underlying thing is the fact that working-class Egyptians are creating Egyptian culture,” he told me. “Whereas from the perspective of local authorities, they’re supposed to be cultural consumers, not cultural producers.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DiT68a">
Censorship of art is a flashpoint in Egypt that Diab himself has grappled with as the space for expression in Egypt has contracted since the 2013 military takeover. Diab’s most recent film <a href="https://www.imdb.com/title/tt5599692/"><em>Clash</em></a> is the claustrophobic story of conflicting political activists, Muslim Brotherhood protesters who demonstrated against Sisi, and secular critics, journalists, and others caught in the wrong place. They’re all locked together in the back of a large police van, as Cairo convulses with political carnage during the coup. The regime saw his depiction of the <a href="https://www.madamasr.com/en/2016/08/11/feature/culture/clash-an-awkward-movie-that-suits-an-awkward-
situation/">complexity of Egyptian politics</a> as criticism. When it premiered in 2016, it was only in Egyptian theaters for a <a href="https://www.hollywoodreporter.com/news/general-news/egypts-hit-clash-an-oscar-2017-hopeful-
censorship-battles-953358/">truncated run</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2biZSt">
The mahraganat tracks in <em>Moon Knight</em> have brought to life scenes of contemporary Egypt at a particularly difficult time for Egyptians. The Sisi government has jailed <a href="https://www.washingtonpost.com/opinions/2021/02/24/egypt-political-prisoners-sissi-fear/">tens of thousands</a> of political prisoners. One of the most prominent voices of the 2011 revolution, activist and blogger <a href="https://www.washingtonpost.com/world/2022/05/03/egypt-prison-alaa-abdelfattah/">Alaa Abd El-Fattah</a>, is seven weeks into a hunger strike, <a href="https://www.theatlantic.com/books/archive/2022/05/egyptian-revolution-alaa-abd-el-
fattah-review/629862/">in protest</a> of the sordid conditions in his prison cell.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LJiWkD">
The series <em>Moon Knight</em> is violent in the way superhero comics are — superficially and sensationally. In Diab’s attempt to bring audiences into the real Egypt, however, he has also shined a light on the actual violence of everyday life in Egypt today, where producing underground rap can lead to fines or jail time, where free expression is all but outlawed.
</p>
<ul>
<li><strong>Days after school shooting, Republicans defend gun rights at NRA convention</strong> -
<figure>
<img alt="Donald Trump and NRA CEO and Executive VP Wayne LaPierre" src="https://cdn.vox-
cdn.com/thumbor/qT2w0Kb_0PTpH9CIfIAMDejAOno=/0x0:4789x3592/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70920979/1399662476.0.jpg"/>
<figcaption>
Former President Donald Trump spoke at the NRA’s annual convention in Houston this week amid public criticism against the event after the Uvelda school shooting. | Brandon Bell/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Former President Trump and Texas Sen. Ted Cruz were among those dismissing calls for tougher gun laws.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4osbYo">
“The rate of gun ownership hasn’t changed. And yet acts of evil like we saw this week are on the rise,” Texas Sen. Ted Cruz told crowds at the National Rifle Association’s convention in Houston this week. Cruz’s claim about stagnant gun ownership, which is <a href="https://www.nytimes.com/2022/05/27/us/politics/fact-check-trump-cruz-nra.html">factually misleading</a>, is among the trove of inaccurate claims made by Republican officials at the NRA’s annual gathering this year, making clear that the string of mass shootings in recent weeks has not influenced their pro-gun convictions, in spite of several slated speakers pulling their participation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Yhit7n">
The NRA kicked off its annual convention — featuring firearms exhibitions and speaking appearances from pro-gun Republican officials — on Thursday, only days after a gunman killed 19 school children and two teachers at an elementary school in Uvalde. The group’s decision to go ahead with its yearly gathering drew thousands of protesters outside of the convention’s venue.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i8E4YA">
Texas governor hopeful Beto O’Rourke, the former Democratic presidential candidate <a href="https://www.texastribune.org/2022/05/25/beto-orourke-
greg-abbott-uvalde-shooting/">who confronted</a> current Texas Governor, Greg Abbott, over the school shooting at a press conference this week, was among the protesters.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WRbnp5">
“I hope you agree with me, that the time for us to have stopped Uvalde was right after Sandy Hook,” O’Rourke <a href="https://www.chron.com/news/houston-
texas/article/Protesters-gather-outside-NRA-convention-in-17203581.php">told</a> the crowd. “The time for us to have stopped Uvalde was right after Parkland. The time for us to have stopped Uvalde was right after Santa Fe High School. The time for us to stop mass shootings in this country is right now, right here, today.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4K2xCi">
An estimated 4,000 protesters showed up outside of Houston’s George R. Brown Convention Center on Friday when ex-President Donald Trump and a string of high-profile Republican officials — including Texas Sen. Ted Cruz and South Dakota Gov. Kristi Noem — were expected to speak at the gun-lobbying event.
</p>
<div id="GBW4wB">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
At Discovery Green across the George R. Brown Convention Center in Houston where people have gathered to protest the NRA’s annual convention set to take place there following the Robb Elementary School schooting in Uvalde, Texas earlier this week. <a href="https://t.co/YsVBI8qnOX">pic.twitter.com/YsVBI8qnOX</a>
</p>
— Ariana Garcia
<ol class="example" type="1">
<li><a href="https://twitter.com/Ariana_noGrande/status/1530235378183069696?ref_src=twsrc%5Etfw">May 27, 2022</a></li>
</ol>
</blockquote></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aj0scC">
Multiple elected officials pulled out of their planned appearances at the NRA convention last minute, following heavy criticism.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IXpYQ4">
“While a strong supporter of the Second Amendment and an NRA member, I would not want my appearance today to bring any additional pain or grief to the families and all those suffering in Uvalde,” Texas<strong> </strong>Lt. Gov. Dan Patrick said in a statement <a href="https://twitter.com/DanPatrick/status/1530191083426271233">posted</a> on Twitter.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ng3LCH">
Gov. Abbott, who was scheduled to speak at the convention’s marquee “Leadership Forum,” opted instead to address attendees through a pre-recorded message. Sen. John Cornyn and Rep. Dan Crenshaw — both Texas Republicans — also backed out of the NRA gathering citing scheduling conflicts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ftn2ua">
Despite the controversy surrounding its gathering, NRA leadership and its supporters remained steadfast in their pro-gun stance, even as the public calls for stricter gun laws.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U6FlQV">
In his opening remarks, NRA chief executive Wayne LaPierre acknowledged the “21 beautiful lives ruthlessly and indiscriminately extinguished by a criminal monster” while still arguing that “restricting the fundamental human rights of law-abiding Americans to defend themselves is not the answer.”
</p>
<h3 id="3XSk5k">
Trump mocked Republicans who pulled out of the NRA convention
</h3>
<figure class="e-image">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><img alt="Trump standing
at the podium against a dark blue backdrop." src="https://cdn.vox-
cdn.com/thumbor/CYPHdl98-CQBHb0v9pPS6BU15UE=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23594400/1399664344.jpg"/> <cite>Brandon Bell/Getty Images</cite></p>
<figcaption>
Trump took a swipe at GOP elected officials for canceling their appearances at the NRA convention in Houston.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o8U3BC">
This year’s four-day event — the first NRA convention since the annual gathering’s prior postponements due to the pandemic — featured a line-up of high-profile speakers from the Republican party railing against public calls for tougher gun laws.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AvHWYZ">
Sen. Cruz, who is considered a potential contender for the GOP’s presidential ticket in 2024, dismissed enacting stronger gun policies such as universal background checks on gun purchases and banning assault rifles. Instead, Cruz blamed America’s gun violence epidemic on things like video games, declining church attendance, and social media.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xX89OO">
“Tragedies like the event of this week are a mirror forcing us to ask hard questions, demanding that we see where our culture is failing,” Cruz <a href="https://apnews.com/article/uvalde-school-shooting-nra-convention-212dfd1b57474f1ab208d4a72521a010">said</a>. “We must not react to evil and tragedy by abandoning the Constitution or infringing on the rights of our law-abiding citizens.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bFbh64">
Trump’s speech, meanwhile, was peppered with the typical jabs and gimmicks that colored his presidency. Firearms and other lethal weapons were <a href="https://www.usatoday.com/story/news/factcheck/2022/05/27/fact-check-guns-banned-from-trump-nra-speech-over-secret-
service-policy/9947390002/">banned</a> from the general hall assembly during Trump’s speech, based on security protocols from the US Secret Service.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5DRMUe">
Trump began his speech by mocking Republican officials for pulling out of the event.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tc5L9w">
“Unlike some others, I didn’t disappoint you by not showing up today,” Trump <a href="https://www.cbsnews.com/live-updates/nra-convention-houston-texas-mass-shooting-2022-05-27/">told</a> the crowd. He then read out the names of the Uvalde shooting victims — each followed by a gong sound.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6O703h">
During his speech, Trump reinforced the same talking points Sen. Cruz did, focusing on other societal ills like “broken families” and mental health as the primary problems facing Americans. Trump also called for toughening school security measures — <a href="https://www.thetrace.org/2017/03/gun-free-zone-facts/">falsely claiming</a> that gun-free zones made schools less safe — and praised Texas law enforcement despite reports revealing local police’s <a href="https://www.vox.com/2022/5/27/23143997/the-uvalde-police-keep-changing-their-story">questionable response</a> to the Uvalde school shooting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B6dFJt">
During his appearance, Trump invited Jack Wilson, a man who had stopped a shooting at a Texas church in 2019, to join him on stage. Wilson <a href="https://www.cbsnews.com/live-
updates/nra-convention-houston-texas-mass-shooting-2022-05-27/">said</a> he “didn’t kill — I took out evil” and praised Trump, saying “you’re still our president.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VnaHDW">
The doubling-down on rhetoric about protecting the public’s right to bear arms by NRA leadership and its supporters, even as another group of schoolchildren is massacred by an assault weapon-wielding gunman, is part of a historical trend in the US response to mass shootings, as <a href="https://www.vox.com/policy-and-politics/23142829/uvalde-robb-elementary-mass-shooting-gun-politcal-
science">reported</a> by Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Bx4lXD">
In 2020, a <a href="https://www.sciencedirect.com/science/article/pii/S0047272719301446?via%3Dihub">study</a> in the Journal of Public Economics found that state-level responses following mass shootings heavily tilted toward loosening, not tightening, gun regulations.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SRrOvF">
As the authors wrote: “In states with Republican-controlled legislatures, a mass shooting roughly doubles the number of laws enacted that loosen gun restrictions in the year following the incident. We find no significant effect of mass shootings on laws enacted when there is a Democrat-controlled legislature.” The researchers also noted no significant effect on the number of tighter gun laws, meaning the country’s frequent mass shootings did little in the way of broadly spurring better gun control laws.
</p>
<h3 id="cl89gr">
Controversy over the gathering is the latest to hit the NRA
</h3>
<figure class="e-image">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><img alt="A crowd of protesters gathered
around an outdoor stage." src="https://cdn.vox-
cdn.com/thumbor/196eUz8rvKw8-l8UBTGaoiBsyiE=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23594406/1240942098.jpg"/> <cite>Cecile Clocheret/AFP via Getty Images</cite></p>
<figcaption>
Texas Democratic gubernatorial candidate Beto O’Rourke (pictured speaking) was among thousands of protesters outside the NRA convention venue in Houston, Texas.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bFwOqO">
The NRA has been one of the most influential lobbying groups in the US for decades. During the 1970s, the organization <a href="https://theconversation.com/how-the-nra-evolved-from-backing-a-1934-ban-on-machine-guns-to-blocking-nearly-all-
firearm-restrictions-
today-183880?utm_medium=email&amp;utm_campaign=Daily%20Newsletter%20May%2026%202022%20-%202303722926&amp;utm_content=Daily%20Newsletter%20May%2026%202022%20-%202303722926+CID_7d3dd27e400566725aa9042ad8b2ec54&amp;utm_source=campaign_monitor_us&amp;utm_term=tracing%20the%20NRAs%20long%20history">evolved</a> from its original purpose as a gun safety advocacy group into a guns-first lobbying force. Since then, in order to maintain influence, the NRA has pushed legislation to <a href="https://www.npr.org/2018/04/05/599773911/how-the-nra-
worked-to-stifle-gun-violence-research">slow down</a> gun violence-related research and increase accessibility to gun ownership.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6DcTJJ">
At the same time, the NRA has weathered increasing instability, brought on by factors both internal and external. A <a href="https://www.usatoday.com/story/news/politics/2019/04/27/nra-president-oliver-
north-convention-indianapolis-speech-power-struggle/3598606002/">power struggle</a> began to foment inside the organization in 2019 after then-NRA president Oliver North accused current CEO Wayne LaPierre of money embezzlement. Although the NRA continued to secure the support of conservative lawmakers in pushing its legislative agenda, internal discord fractured the group.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vwrLde">
In spite of legislative wins, the NRA has experienced a massive loss of income in recent years. In 2018, The Daily Beast <a href="https://www.thedailybeast.com/the-nra-just-reported-losing-
dollar55-million-in-income">reported</a> the NRA experienced a $55 million decline in income, based on its tax records from the year prior. The organization also recorded a decline of about <a href="https://www.npr.org/2018/11/29/671799992/nra-2017-tax-records-reveal-decline-in-income">22 percent</a> in membership dues that same year. More recently, between 2016 to 2020, the NRA’s revenue dropped 23 percent from roughly $367 million to $282 million, according to <a href="https://www.cbsnews.com/news/nra-national-rifle-association-
membership-revenue-2022/">CBS News</a>. Additionally, contributions from its members and private companies have slipped 15 percent during that same period.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X8j2Cz">
Beyond its internal woes, the NRA has also faced litigation. In August 2020, New York Attorney General Letitia James filed a lawsuit to dissolve the organization completely based on alleged mishandling of the nonprofit group’s finances by its executives. A judge <a href="https://www.nbcnews.com/news/us-news/bid-shutter-nra-rejected-judge-lawsuit-group-can-proceed-
rcna18500">blocked</a> New York’s lawsuit to disband the NRA but ruled to allow the AG’s complaint over alleged illegal financial activities by NRA leadership to continue.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Lnoh53">
Separate from the NRA’s battles to maintain its influence, public opinion among Americans has shifted to becoming friendlier toward gun control proposals. Although opinions around gun law reforms have fluctuated in recent years, overall polls show a growing number of Americans support tougher gun laws.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tyYG6n">
A <a href="https://www.politico.com/f/?id=00000180-fe72-d0c2-a9ae-
ff7250f80000&amp;nname=playbook&amp;nid=0000014f-1646-d88f-a1cf-5f46b7bd0000&amp;nrid=0000014e-f115-dd93-ad7f-f91513e50001&amp;nlid=630318">survey</a> by the Morning Consult and Politico, conducted last week after the Ulvade school shooting, showed 73 percent of survey- takers “strongly support” universal background checks.
</p>
<div id="wAKi8m">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
I’m a gun owner, and a hunting guide, and a combat veteran. I also believe <a href="https://twitter.com/NRA?ref_src=twsrc%5Etfw"><span class="citation" data-cites="NRA">@NRA</span></a> is one of the most irresponsible and destructive lobbies in America. This culture of make-believe special operators, supported by politicians, is insane. <a href="https://twitter.com/hashtag/GunOwnersForSafety?src=hash&amp;ref_src=twsrc%5Etfw">#GunOwnersForSafety</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">— Nate Fick (<span class="citation" data-cites="ncfick">@ncfick</span>) <a href="https://twitter.com/ncfick/status/1530188603829194752?ref_src=twsrc%5Etfw">May 27, 2022</a></p>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nnHzrZ">
Additionally, 84 percent of respondents stated they would support “preventing sales of all firearms” to people flagged as “dangerous” to law enforcement by mental health providers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jaAf7E">
The overwhelming public support for better gun control laws shouldn’t come as a surprise after decades of repeated mass shootings in the US. As this <a href="https://www.vox.com/a/mass-shootings-america-sandy-hook-gun-
violence">interactive data map</a> by Vox shows, as of July 2020, over 2,600 more mass shootings have happened in the decade since the Sandy Hook school shooting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FpviDV">
Still, despite overwhelming public support for stricter gun control regulations, pro-gun lawmakers appear unmoved in shifting toward gun law reforms, likely due to the millions of dollars worth of campaign donations from the NRA. According to Brady, one of the country’s largest gun violence prevention groups, the NRA <a href="https://elections.bradyunited.org/take-action/nra-donations-116th-congress-
senators">spent</a> $3.2 million toward campaign contributions for pro-gun lawmakers in 2019 and $2.2 million in campaign donations in 2020.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DXejg4">
Despite setbacks the group has endured,<strong> </strong>some believe the NRA’s biggest legacy will outlast the organization itself, and that will likely continue to prevent any meaningful progress on the country’s gun reforms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eaMkBs">
“Ultimately, the NRA is a profoundly weaker and more divided organization than it once was,” <a href="https://www.politico.com/news/magazine/2022/05/27/nra-civil-war-ideology-
voters-republican-politicians-00035589?utm_source=pocket_mylist">wrote</a> Frank Smyth, an investigative journalist and author of the 2020 book The NRA: The Unauthorized History, for Politico. “But its legacy, even if it fails to survive, will be the culture and ideology of gun rights it helped cultivate, and that is a potent thing for many conservative voters and the Republican politicians who chase them.”
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sethu 15th</strong> - Sports Bureau</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India lose friendly against Jordan ahead of AFC Asian Cup qualifier</strong> - Despite the returning Sunil Chhetri, India goes down 2-0 against Jordan in the Qatar Sport Club Stadium, 10 days ahead of their third round of AFC Asian Cup qualifier against Cambodia scheduled for June 8</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Legendary jockey Lester Piggott dies aged 86</strong> - Piggott rode his first winner, The Chase, at Haydock in 1948 when just 12 years of age and his last win came with Palacegate Jack at the same track in 1994, a few weeks short of his 59th birthday. He retired for a final time in 1995.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leclerc puts Ferrari on pole in Monaco Grand Prix as Perez crashes</strong> - In three previous starts on Monaco’s city streets, Leclerc retired twice with crash damage and failed to start</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UEFA Champions League | Real Madrid beats Liverpool 1-0 for 14th European Cup title</strong> - Real Madrid became European champion for a record-extending 14th time after beating Liverpool 1-0 in the Champions League final</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Stay away from anti-social elements, tribal youth told</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>359 students to be given gold medals at open university convocation</strong> - 19,363 to receive their degrees at the TNOU convocation; a BCA student from Coimbatore wins ₹25,000 cash prize from the Commonwealth Educational Media Centre for Asia</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Teenmaar Mallanna detained during farmers’ meet, let off</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Halt Haritha Haaram in podu lands: BJP</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>West Kallada sets a goal of graduating all residents</strong> - Grama panchayat joining hands with Sree Narayana Guru Open University to achieve the feat</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Putin urged to hold ‘direct, serious negotiations’ with Zelensky</strong> - In a lengthy call with Russia’s leader, France and Germany urge “serious” talks as fighting rages.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia won’t use tactical nuclear weapons in Ukraine, says ambassador to UK</strong> - Andrei Kelin tells the BBC tactical nuclear weapons have “nothing to do” with operations in Ukraine.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine: Two sisters fled their home, but carried on their martial arts training</strong> - Two sisters, who are world champions in mixed martial arts, want to compete for Ukraine.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Liverpool 0-1 Real Madrid: Reds beaten in Paris as Vinicius Jr hits winner</strong> - Liverpool’s hopes of being crowned champions of Europe for a seventh time ends in heartbreak at the hands of Real Madrid in Paris.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Palme d’Or: Triangle of Sadness wins top prize in Cannes for Ruben Ostlund</strong> - Ruben Ostlund’s Triangle of Sadness takes the Palme d’Or on a good night for South Koreans too.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The mystery of China’s sudden warnings about US hackers</strong> - China has recently begun saber-rattling about American cyberespionage. - <a href="https://arstechnica.com/?p=1856999">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Who owns 4chan?</strong> - 4chan’s relationship with a Japanese toymaker has remained remarkably murky. - <a href="https://arstechnica.com/?p=1856881">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The best Memorial Day sales we can find on gadgets, games, and tech gear</strong> - Dealmaster includes MacBooks, Bose headphones, lots of PlayStation deals, and more. - <a href="https://arstechnica.com/?p=1857105">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>We tasted the expanded collection of Star Trek wines and found them… wanting</strong> - <em>Picard</em>’s John de Lancie (aka Q) joined Ars for an informal Star Trek-themed wine tasting - <a href="https://arstechnica.com/?p=1856835">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sony accelerates push into car sector in diversification drive</strong> - Wants to supply electric and autonomous vehicle sensors by 2025. - <a href="https://arstechnica.com/?p=1857027">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A homeless man asked me for money I had 20 dollars in my pocket and didn’t want it to just go towards crack and alcohol</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
So I gave it to the homeless man
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Slit23"> /u/Slit23 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/uzxtmm/a_homeless_man_asked_me_for_money_i_had_20/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/uzxtmm/a_homeless_man_asked_me_for_money_i_had_20/">[comments]</a></span></p></li>
<li><strong>A domestic abuser, a klansmen, and a murderer walk into a bar.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Bartender: what will it be, officer?
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/audio_inferno"> /u/audio_inferno </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v07dqo/a_domestic_abuser_a_klansmen_and_a_murderer_walk/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v07dqo/a_domestic_abuser_a_klansmen_and_a_murderer_walk/">[comments]</a></span></p></li>
<li><strong>A chicken walks over to a duck standing on the side of the road. The duck is considering crossing to the other side.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Don’t do it, pal,” the chicken says. “You’ll never hear the end of it.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/iam_stupid23"> /u/iam_stupid23 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v02apg/a_chicken_walks_over_to_a_duck_standing_on_the/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v02apg/a_chicken_walks_over_to_a_duck_standing_on_the/">[comments]</a></span></p></li>
<li><strong>A duck walks into a store…</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He shouts at the proprietor, “Hey! Got any duck food?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The store proprietor answers, “No, we don’t.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The next day, the duck returns, and asks, “Hey! Got any duck food?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The store proprietor says, “I told you yesterday, we don’t have any duck food. Now please leave.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The next day, the duck return, and asks, “Hey! Got any duck food?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The store proprietor says, “For the last time, we don’t have any duck food! And if you come back here and ask again, I’m gonna nail your feet to the floor!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The next day, the duck returns, and asks, “Hey! Got any nails?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The store proprietor answers, “No, we don’t.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The duck replies, “Good! Got any duck food?”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/jfincher42"> /u/jfincher42 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v01e7s/a_duck_walks_into_a_store/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v01e7s/a_duck_walks_into_a_store/">[comments]</a></span></p></li>
<li><strong>If Joe Biden’s wife is called the first lady, what do we call his mother?</strong> - <!-- SC_OFF -->
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Joe mama.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/vank1219"> /u/vank1219 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v0852n/if_joe_bidens_wife_is_called_the_first_lady_what/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v0852n/if_joe_bidens_wife_is_called_the_first_lady_what/">[comments]</a></span></p></li>
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