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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Immunogenicity and Safety of Beta Adjuvanted Recombinant Booster Vaccine</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background. Variant-adaptated vaccines against coronavirus disease 2019 (COVID-19) as boosters are needed to increase a broader protection against SARS CoV-2 variants. New adjuvanted recombinant protein vaccines as heterologous boosters could maximize the response. Methods. In this randomized, single-blinded, multicenter trial, adults who had received two doses of Pfizer-BioNTech mRNA vaccine (BNT162b2) 3 to7 months before were randomly assigned to receive a boost of BNT162b2, Sanofi/GSK SARS-CoV-2 adjuvanted recombinant protein MV D614 (monovalent parental formulation) or SARS-CoV-2 adjuvanted recombinant protein MV B.1.351 vaccine (monovalent Beta formulation). The primary endpoint was the percentage of subjects with a ≥ 10-fold increase in neutralizing antibody titers for the Wuhan (D614) and B.1.351 (Beta) SARS-CoV-2 viral strains between day 0 and day 15. Findings. The percentages of participants whose neutralizing antibody titers against the Wuhan (D614) SARS-CoV-2 strain increased by a factor ≥10 between day 0 and day 15 was 55.3% (95% CI 43.4-66.7) in MV D614 group (n=76), 76.1% (64.5-85.4) in MV B.1.351 (Beta) group (n=71) and 63.2% (51.3-73.9) in BNT162b2 group (n=76). These percentages were 44.7% (33.3-56.6), 84.5% (74.0-92.0) and 51.3% (39.6-63.0) for the B.1.351 (Beta) viral strain, respectively. Higher neutralizing antibodies rates against Delta and Omicron BA.1 variants were also elicited after Sanofi/GSK MV Beta vaccine compared to the other vaccines. Comparable reactogenicity profile was observed with the three vaccines. Interpretation. Heterologous boosting with the Sanofi/GSK Beta formulation vaccine resulted in a higher neutralizing antibody response against Beta variant but also the original strain and Delta and Omicron BA.1 variants, compared with mRNA BNT162b2 vaccine or the Sanofi/GSK MVD614 formulation. New vaccines containing Beta spike protein may represent an interesting strategy for broader protection against SARS CoV-2 variants.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.25.22274904v1" target="_blank">Immunogenicity and Safety of Beta Adjuvanted Recombinant Booster Vaccine</a>
</div></li>
<li><strong>A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Importance: While much of the attention on the COVID-19 pandemic was directed at the daily counts of cases and those with serious disease overwhelming health services, increasingly, reports have appeared of people who experience debilitating symptoms after the initial infection. This is popularly known as long COVID. Objective: To estimate by country and territory of the number of patients affected by long COVID in 2020 and 2021, the severity of their symptoms and expected pattern of recovery Design: We jointly analyzed ten ongoing cohort studies in ten countries for the occurrence of three major symptom clusters of long COVID among representative COVID cases. The defining symptoms of the three clusters (fatigue, cognitive problems, and shortness of breath) are explicitly mentioned in the WHO clinical case definition. For incidence of long COVID, we adopted the minimum duration after infection of three months from the WHO case definition. We pooled data from the contributing studies, two large medical record databases in the United States, and findings from 44 published studies using a Bayesian meta-regression tool. We separately estimated occurrence and pattern of recovery in patients with milder acute infections and those hospitalized. We estimated the incidence and prevalence of long COVID globally and by country in 2020 and 2021 as well as the severity-weighted prevalence using disability weights from the Global Burden of Disease study. Results: Analyses are based on detailed information for 1906 community infections and 10526 hospitalized patients from the ten collaborating cohorts, three of which included children. We added published data on 37262 community infections and 9540 hospitalized patients as well as ICD-coded medical record data concerning 1.3 million infections. Globally, in 2020 and 2021, 144.7 million (95% uncertainty interval [UI] 54.8-312.9) people suffered from any of the three symptom clusters of long COVID. This corresponds to 3.69% (1.38-7.96) of all infections. The fatigue, respiratory, and cognitive clusters occurred in 51.0% (16.9-92.4), 60.4% (18.9-89.1), and 35.4% (9.4-75.1) of long COVID cases, respectively. Those with milder acute COVID-19 cases had a quicker estimated recovery (median duration 3.99 months [IQR 3.84-4.20]) than those admitted for the acute infection (median duration 8.84 months [IQR 8.10-9.78]). At twelve months, 15.1% (10.3-21.1) continued to experience long COVID symptoms. Conclusions and relevance: The occurrence of debilitating ongoing symptoms of COVID-19 is common. Knowing how many people are affected, and for how long, is important to plan for rehabilitative services and support to return to social activities, places of learning, and the workplace when symptoms start to wane.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.26.22275532v1" target="_blank">A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021</a>
</div></li>
<li><strong>Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids</strong> -
<div>
While pluripotent stem cell-derived kidney organoids are now being used to model renal disease, the proximal nephron remains immature with limited evidence for key functional solute channels. This may reflect early mispatterning of the nephrogenic mesenchyme and/or insufficient maturation. Here we show that enhanced specification to metanephric nephron progenitors results in elongated and radially aligned proximalised nephrons with distinct S1 - S3 proximal tubule cell types. Such PT-enhanced organoids possess improved albumin and organic cation uptake, appropriate KIM-1 upregulation in response to cisplatin, and improved expression of SARS-CoV-2 entry factors resulting in increased viral replication. The striking proximo-distal orientation of nephrons resulted from localized WNT antagonism originating from the organoid stromal core. PT-enhanced organoids represent an improved model to study inherited and acquired proximal tubular disease as well as drug and viral responses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.10.14.464320v2" target="_blank">Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids</a>
</div></li>
<li><strong>Mapping the Perception-space of Facial Expressions in the Era of Face Masks</strong> -
<div>
With the advent of the SARS-CoV-2 pandemic, the theme of emotion recognition from facial expressions has become highly relevant due to the widespread use of face masks as one of the main devices imposed to counter the spread of the virus. Unsurprisingly, several studies published in the last two years have shown that accuracy in the recognition of basic emotions expressed by faces wearing masks is reduced. However, less is known about the impact that wearing face masks has on the ability to recognize emotions from subtle expressions. Furthermore, even less is known regarding the role of interindividual differences (such as alexithymic and autistic traits) in emotion processing. This study investigated the perception of all the six basic emotions (anger, disgust, fear, happiness, sadness, and surprise) both as a function of the face mask and as a function of the facial expressions’ intensity (full vs. subtle) in terms of participants’ uncertainty in their responses, misattribution errors and perceived intensity. The experiment was conducted online on a large sample of participants (N=129). Participants completed the 20-item Toronto Alexithymia Scale and the Autistic Spectrum Quotient and then performed an emotion-recognition task which involved face stimuli wearing a mask or not and displaying full or subtle expressions. Each face stimulus was presented alongside the Geneva Emotion Wheel (GEW) and participants had to indicate what emotion they believed the other person was feeling and its intensity by means of the GEW. For each combination of our variables, we computed the indices of ‘uncertainty’ (i.e., the spread of responses around the correct emotion category), ‘bias’ (i.e., the systematic errors in recognition) and ‘perceived intensity’ (i.e., the distance from the center of the GEW). We found that face masks increase uncertainty for all facial expressions of emotion, except for fear when intense, and that disgust was systematically confused with anger (i.e. response bias). Furthermore, when faces were covered by the mask, all the emotions were perceived as less intense, and this was particularly evident for subtle expressions. Finally, we did not find any evidence of a relationship between these indices and alexithymic/autistic traits.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/wp4k5/" target="_blank">Mapping the Perception-space of Facial Expressions in the Era of Face Masks</a>
</div></li>
<li><strong>Facing the Omicron variant - How well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic review</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The SARS-CoV-2 Omicron variant is currently the dominant variant globally. This 3rd interim analysis of a living systematic review summarizes evidence on COVID-19 vaccine effectiveness (VE) and duration of protection against Omicron. Methods: We systematically searched the COVID-19 literature for controlled studies evaluating the effectiveness of COVID-19 vaccines approved in the European Union up to 14/01/2022, complemented by hand-searches of websites and metasearch engines up to 11/02/2022. We considered the following comparisons: full primary immunization vs. no vaccination; booster immunization vs. no vaccination; booster vs. primary immunization. VE against any confirmed SARS-CoV-2 infection, symptomatic, and severe COVID-19 (i.e. COVID-19-related hospitalization, ICU-admission, or death) was indicated providing estimate ranges. Meta-analysis was not performed due to high study heterogeneity. Risk of bias was assessed with ROBINS-I, certainty of evidence evaluated using GRADE. Results: We identified 26 studies, including 430 to 2.2 million participants. VE against any confirmed SARS-CoV-2 infection compared to no vaccination ranged between 0-62% after full primary immunization, and between 34-66% after a booster dose. VE-range for booster vs. primary immunization was 34-54.6%. Against symptomatic COVID-19, VE ranged between 6-76% after full primary immunization, and between 19-73.9% after booster immunization, if compared to no vaccination. When comparing booster vs. primary immunization VE ranged between 56-69%. VE against severe COVID-19 compared to no vaccination ranged between 3-84% after full primary immunization, and between 12-100% after a booster dose. One study compared booster vs. primary immunization (VE 100%, 95% CI 71.4-100). VE was characterized by a moderate to strong decline within three to six months for SARS- CoV-2 infections and symptomatic COVID-19. Against severe COVID-19 protection remained robust at least for up to six months. Waning immunity was more profound after primary than booster immunization. Risk of bias was moderate to critical across studies and outcomes. GRADE-certainty was very low for all outcomes. Author9s conclusions: Under the Omicron variant, effectiveness of EU-licensed COVID-19 vaccines in preventing any SARS-CoV-2 infection or mild disease is low and only short-lasting after primary immunization, but can be improved by booster vaccination. VE against severe COVID-19 remains high and is long-lasting, especially after receiving the booster vaccination.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.25.22275516v1" target="_blank">Facing the Omicron variant - How well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic review</a>
</div></li>
<li><strong>How is the COVID-19 pandemic impacting our life, mental health, and well-being? Design and preliminary findings of the pan-Canadian longitudinal COHESION Study</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Abstract With the advent of the COVID-19 pandemic, in-person social interactions and opportunities for accessing resources that sustain health and well-being have drastically reduced. We therefore designed the pan-Canadian population-based prospective COVID-19: HEalth and Social Inequities across Neighbourhoods (COHESION) cohort to provide deeper understanding of how the COVID-19 pandemic context affects mental health and well-being, key determinants of health, and health inequities. This paper presents the design of the two-phase COHESION Study, and descriptive results from the first phase conducted between May 2020 and September 2021. During that period, the COHESION research platform collected monthly data linked to COVID-19 such as infection and vaccination status, perceptions and attitudes regarding pandemic-related measures, and information on participants’ physical and mental health, well-being, sleep, loneliness, resilience, substances use, living conditions, social interactions, activities, and mobility. The 1,268 people enrolled in the Phase 1 COHESION Study are for the most part from Ontario (47%) and Quebec (33%), aged 48 ± 16 years [mean± standard deviation (SD)], and mainly women (78%), White (85%), with a university degree (63%), and living in large urban centers (70%). According to the 298 ± 68 (mean ± SD) prospective questionnaires completed each month in average, the first year of follow-up reveals significant temporal variations in standardized indexes of well-being, loneliness, anxiety, depression, and psychological distress. The COHESION Study will allow identifying trajectories of mental health and well-being while investigating their determinants and how these may vary by subgroup, over time, and across different provinces in Canada, in the unique context of the COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.26.22275645v1" target="_blank">How is the COVID-19 pandemic impacting our life, mental health, and well-being? Design and preliminary findings of the pan-Canadian longitudinal COHESION Study</a>
</div></li>
<li><strong>Omicron reactive multi protein specific CD4 T cells defines cellular immune response induced by inactivated virus vaccines.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Unlike mRNA vaccines based only on the Spike protein, inactivated SARS-CoV-2 vaccines should induce a diversified T cell response recognizing distinct structural proteins. Here we performed a comparative analysis of SARS- CoV-2 specific T cells in healthy individuals following vaccination with inactivated SARS-CoV-2 or mRNA vaccines. Relative to Spike mRNA vaccination, inactivated vaccines elicited a lower magnitude of Spike-specific T cells, but the combined Membrane, Nucleoprotein and Spike specific T cell response was quantitatively comparable to the sole Spike T cell response induced by mRNA vaccines, and they efficiently tolerate the mutations characterizing the Omicron lineage. However, this multi-protein specific T cell response was not mediated by a coordinated CD4 and CD8 T cell expansion but by selected priming of CD4 T cells. These findings can help in defining the role of CD4 and CD8 T cells in the efficacy of the different vaccines to control severe COVID-19 after Omicron infection.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.25.22275616v1" target="_blank">Omicron reactive multi protein specific CD4 T cells defines cellular immune response induced by inactivated virus vaccines.</a>
</div></li>
<li><strong>Covid-19 is a leading cause of death in children and young people ages 0-19 years in the United States</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Covid-19 has caused more than 1 million deaths in the US, including at least 1,433 deaths among children and young people (CYP) aged 0-19 years. Deaths among US CYP are rare in general, and so we argue here that the mortality burden of Covid-19 in CYP is best understood in the context of all other causes of CYP death. Using publicly available data from the National Center for Health Statistics, and comparing to mortality in 2019, the immediate pre-pandemic period, we find that Covid-19 is a leading cause of death in CYP aged 0-19 years in the US, ranking #9 among all causes of deaths, #5 in disease related causes of deaths (excluding accidents, assault and suicide), and #1 in deaths caused by infectious / respiratory diseases. Due to the impact of mitigations such as social distancing and our comparison of a single disease (Covid-19) to groups of causes such as deaths from pneumonia and influenza, these rankings are likely conservative lower bounds. Our findings underscore the importance of continued vaccination campaigns for CYP over 5 years of age in the US and for effective Covid-19 vaccines for under 5 year olds.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.23.22275458v2" target="_blank">Covid-19 is a leading cause of death in children and young people ages 0-19 years in the United States</a>
</div></li>
<li><strong>Infectiousness in omicron variant strain and bA.2 variant in Japan</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Omicron variant strain dominated since the beginning of 2022. Its infectivity was supposes to be higher than Delta variant strain or strains in past. Object: We estimated prevalence of omicron variant strain, particularly bA.2 variant and COVID-19 vaccine effectiveness of the third dose in Japan as well as controlling for waning of second dose of vaccine, other mutated strains, the Olympic Games, and countermeasures. Method: The effective reproduction number R(t) was regressed on shares of omicron variant strain and bA.2 and vaccine coverage of the third dose, as well as along with data of temperature, humidity, mobility, share of the other mutated strains, and an Olympic Games and countermeasures. The study period was February, 2020 through February 21, 2022, as of March 15, 2022. Results : Estimation results indicated that waning of the second dose vaccine e with 150 days prior was the most appropriate specification. Moreover, bA.2 of omicron variant strain has higher infectively than other variant strain or traditional strain. Discussion: Because of data limitation since emerging bA.2, the estimated its infectively will change over time.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.20.21259209v7" target="_blank">Infectiousness in omicron variant strain and bA.2 variant in Japan</a>
</div></li>
<li><strong>Epidemiological Interactions of Influenza and SARS-CoV-2 within a University Population During Omicron B.1.1.529 Outbreak</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The COVID-19 Pandemic has prompted innovation and research to further understand not only SARS-CoV-2, but other respiratory viruses as well. Since the start of the pandemic there has been a lack in influenza collection and surveillance. In October 2021 the Life Sciences Testing Center at Northeastern University implemented the TaqPath™ COVID-19, Flu A, Flu B combo kit to test for multiple respiratory diseases among the University’s population. During this time the SARS- CoV-2 variant of concern, Omicron B.1.1.529, became the dominant strain in the greater Boston area. During this time an inverse correlation in the detection of positive SARS-CoV-2 and Influenza A was observed. More data is needed to determine if this observed inverse correlation on positivity rate is linked to public health measures or biological mechanism within the immune system.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.26.22275641v1" target="_blank">Epidemiological Interactions of Influenza and SARS-CoV-2 within a University Population During Omicron B.1.1.529 Outbreak</a>
</div></li>
<li><strong>A rapid One-Pot RNA-isolation method for simplified clinical detection of SARS-COV-2 infection in India</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: With the rapid increase in COVID-19 cases and the discovery of new viral variants within India over multiple waves, the expensive reagents and time-consuming sample pretreatment required for qPCR analysis have led to slower detection of the disease. The vast Indian population demands an inexpensive and competent sample preparation strategy for rapid detection of the disease facilitating early and efficient containment of the disease. Methods: In this study, we have surveyed the spread of COVID-19 infection over Faridabad, Haryana, India for 6 months. We also devised a simple single-step method for total RNA extraction using a single tube and compared its efficacy with the commercially available kits. Findings: Our findings suggest that determining Ct values for samples subjected to the One Pot (OP) RNA extraction method was as efficient as the commercially available kits but delivers a subtle advantage in a way, by minimizing the cost, labor, and sample preparation time. Conclusion: This novel crude RNA extraction method is stable and capable of operating in developing countries like India for low resource settings, without the use of expensive reagents and instruments. Additionally, this method can be further adapted to pooling samples strategies owing to its high sensitivity.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.26.22275661v1" target="_blank">A rapid One-Pot RNA-isolation method for simplified clinical detection of SARS-COV-2 infection in India</a>
</div></li>
<li><strong>Shared genetic etiology and causality between COVID-19 and venous thromboembolism: evidence from genome-wide cross trait analysis and bi-directional Mendelian randomization study</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Venous thromboembolism (VTE) occurs in up to one third patients with COVID-19. VTE and COVID-19 may share a common genetic architecture, which has not been clarified yet. To fill this gap, we leveraged summary-level genetic data from the latest COVID‐19 host genetics consortium and UK Biobank and examined their shared genetic etiology and causality. The cross-trait analysis identified 8, 11, and 7 shared loci between VTE and severe COVID-19, COVID-19 hospitalization, SARS-CoV-2 infection respectively, in 13 genes involved in coagulation and immune function and enriched in the lung. Co-localization analysis identified eight shared loci in ABO, ADAMTS13 and FUT2 genes. Bi-direction Mendelian randomization suggested that VTE was associated with higher risks of all COVID-19 related traits, and SARS- CoV-2 infection was associated with higher risk of VTE .Our study provided timely evidence and novel insights into the genetic etiology between COVID-19 and VTE.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.21.22275413v2" target="_blank">Shared genetic etiology and causality between COVID-19 and venous thromboembolism: evidence from genome-wide cross trait analysis and bi-directional Mendelian randomization study</a>
</div></li>
<li><strong>An observational study of uptake and adoption of the NHS App in England</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives: This study aimed to evaluate patterns of uptake and adoption of the NHS App. Data metrics from the NHS App were used to assess acceptability by looking at total app downloads, registrations, appointment bookings, GP health records viewed, and prescriptions ordered. The impact of the UK COVID-19 lockdown and introduction of the COVID Pass were also explored to assess App usage and uptake. Methods: Descriptive statistics and an interrupted time series analysis were used to look at monthly NHS App metrics at a GP practice level from January 2019-May 2021 in the population of England. Interrupted time series models were used to identify changes in level and trend among App usage and the different functionalities before and after the first COVID-19 lockdown. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines were used for reporting and analysis. Results: Between January 2019 and May 2021, there were a total of 8,524,882 NHS App downloads and 4,449,869 registrations. There was a 4-fold increase in app downloads from April 2021 (650,558 downloads) to May 2021 (2,668,535 downloads) when the COVID Pass feature was introduced. Areas with the highest number of App registrations proportional to the GP patient population occurred in Hampshire, Southampton and Isle of Wight CCG, and the lowest in Blackburn with Darwen CCG. After the announcement of the first lockdown (March 2020), a positive and significant trend in the number of login sessions was observed at 602,124 (p=0.004)** logins a month. National NHS App appointment bookings ranged from 298 to 42,664 bookings per month during the study period. The number of GP health records viewed increased by an average of 371,656 (p=0.001)** views per month and the number of prescriptions ordered increased by an average of 19934 (p&lt;0.001)*** prescriptions per month following the first lockdown. Conclusion: This analysis has shown that uptake and adoption of the NHS App was positive post lockdown, and increased significantly due to the COVID Pass feature being introduced, but further research is needed to measure the extent to which it improves patient experience and influences health service access and care outcomes.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272200v2" target="_blank">An observational study of uptake and adoption of the NHS App in England</a>
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<li><strong>What works to reduce sedentary behaviour in the office, and could these intervention components transfer to the home working environment?: A rapid review</strong> -
<div>
Background: Working patterns have changed dramatically due to COVID-19, with many workers now spending at least a portion of their working week at home. The office environment was already associated with high levels of sedentary behaviour, and there is emerging evidence that working at home further elevates these levels. The aim of this rapid review (PROSPERO CRD42021278539) was to build on existing evidence to identify what works to reduce sedentary behaviour in an office environment, and consider whether these could be transferable to support those working at home. Methods: The results of a systematic search of databases CENTRAL, MEDLINE, Embase, PsycInfo, CINHAL, and SportDiscus from 10 August 2017 to 6 September 2021 were added to the references included in a 2018 Cochrane review of office based sedentary interventions. These references were screened and controlled peer-reviewed English language studies demonstrating a beneficial direction of effect for office-based interventions on sedentary behaviour outcomes in healthy adults were included. For each study, two of five authors screened the title and abstract, the full-texts, undertook data extraction, and assessed risk of bias on the included studies. Informed by the Behaviour Change Wheel, the most commonly used intervention functions and behaviour change techniques were identified from the extracted data. Finally, a sample of common intervention strategies were evaluated by the researchers and stakeholders for potential transferability to the working at home environment Results: Twenty-two studies including 29 interventions showing a beneficial direction of effect on sedentary outcomes were included. The most commonly used intervention functions were training (n=21), environmental restructuring (n=21), education (n=15), and enablement (n=15). Within these the commonly used behaviour change techniques were instructions on how to perform the behaviour (n=21), adding objects to the environment (n=20), and restructuring the physical environment (n=19). Those strategies with the most promise for transferring to the home environment included education materials, and use of role models, incentives, and prompts. Conclusions: This rapid review has characterized what works to reduce office sedentary behaviour, and identified promising strategies to support workers in the home environment as the world adapts to a new working landscape.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/f96xt/" target="_blank">What works to reduce sedentary behaviour in the office, and could these intervention components transfer to the home working environment?: A rapid review</a>
</div></li>
<li><strong>The Trends of Education after the COVID-19 Situation in Thailand</strong> -
<div>
This research aims to synthesize the views from domestic and international references on the trends of education after COVID-19 situation, then convey the results of the synthesis to the experts from different groups to examine the trends and the feasibility of mix-method research which would be applied in Thai education after COVID-19 situation. The research conducted an in-depth interviewing of 15 experts and used the discussion method with other target groups of 15 experts. The research results defined the proposals of 31 issues for the trends of education after COVID-19 situation in Thailand. These proposals were similar to those of the educational paradigm shift from the 20th to the 21st century. As a result, Thailand is becoming a more digital society and people have to focus on using information and communication technologies (ICT) to gain the maximum benefits to develop the quality of Thai education.
</div>
<div class="article- link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/r6msj/" target="_blank">The Trends of Education after the COVID-19 Situation in Thailand</a>
</div></li>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Safety and Efficacy Study of Hymecromone Tablets for the Treatment of Patients With COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Hymecromone tablets;   Other: Placebo<br/><b>Sponsor</b>:   Shanghai Zhongshan Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on Sequential Immunization of Omicron Inactivated COVID-19 Vaccine and Prototype Inactivated COVID-19 Vaccine in Population Aged 18 Years Old and Above</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Omicron COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: COVID-19 Vaccine (Vero Cell), Inactivated<br/><b>Sponsors</b>:  <br/>
China National Biotec Group Company Limited;   Beijing Institute of Biological Products Co Ltd.;   Hunan Provincial Center for Disease Control and Prevention<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase Ia, Dose-finding Study to Assess the Safety and Immunogenicity of a COVID-19 Vaccine Booster in Healthy Adults</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Prime-2-CoV_Beta<br/><b>Sponsors</b>:  <br/>
University Hospital Tuebingen;   FGK Clinical Research GmbH;   VisMederi srl;   Staburo GmbH;   Viedoc Technologies AB<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Learn About the Study Medicine (Called Nirmatrelvir/Ritonavir) in Pregnant Women With Mild or Moderate COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: nirmatrelvir;   Drug: ritonavir<br/><b>Sponsor</b>:   Pfizer<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of COVID-19 Vaccines Given as a Booster in Healthy Adults in Indonesia (MIACoV Indonesia)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Pfizer-BioNTech Standard dose;   Biological: AstraZeneca Standard dose;   Biological: Pfizer-BioNTech Fractional dose;   Biological: AstraZeneca Fractional dose;   Biological: Moderna Standard dose;   Biological: Moderna Fractional dose<br/><b>Sponsors</b>:   Murdoch Childrens Research Institute;   Universitas Padjadjaran (UNPAD);   Universitas Indonesia (UI);   Health Development Policy Agency, Ministry of Health Republic of Indonesia;   Coalition for Epidemic Preparedness Innovations;   The Peter Doherty Institute for Infection and Immunity<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Efficacy and Safety of DXP604 in Patients With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: DXP604<br/><b>Sponsor</b>:  <br/>
Wuhan Institute of Biological Products Co., Ltd<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sequential Immunization of Two Doses of Inactivated COVID-19 Vaccine (Omicron) in Vaccinated Population Aged 18 Years and Above</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: BIBP Omicron Inactivated COVID-19 vaccine (Vero Cell);   Biological: WIBP Omicron Inactivated COVID-19 vaccine (Vero Cell);   Biological: COVID-19 Vaccine (Vero Cell), Inactivated<br/><b>Sponsors</b>:   China National Biotec Group Company Limited;   Beijing Institute of Biological Products Co Ltd.;   Wuhan Institute of Biological Products Co., Ltd;   The University of Hong Kong<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety of Booster Immunization of COVID-19 Vaccine (Vero Cell), Inactivated (Omicron Variant) in Healthy People Aged 18 Years and Above</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVID-19 Vaccine (Vero cell), Inactivated (Omicron variant);   Biological: COVID-19 Vaccine (Vero cell), Inactivated (CZ strain)<br/><b>Sponsor</b>:  <br/>
Sinovac Research and Development Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Randomized, Open-label, Dose-ranging Study in Adults and Pediatric Individuals ≥ 12 Years of Age to Assess the Safety, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AZD7442, for Pre-exposure Prophylaxis of COVID-19</strong> - <b>Condition</b>:   Coronavirus Disease 2019 (COVID-19)<br/><b>Intervention</b>:   Biological: AZD7442 (tixagevimab [AZD8895] + cilgavimab [AZD1061])<br/><b>Sponsor</b>:   AstraZeneca<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhaled Interferon α2b Treatment in Mild-to-moderate COVID-19 Infected Children</strong> - <b>Conditions</b>:   COVID-19;   Children<br/><b>Interventions</b>:   Drug: Inhaled Interferon α2b;   Other: Standard of Care<br/><b>Sponsors</b>:   Children’s Hospital of Fudan University;   RenJi Hospital;   Shanghai Children’s Hospital;   Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>INTEGrating Ag-RDTs for COVID in MNCH,HIV and TB Services in Cameroon and Kenya:A Cluster Randomized Trial of Two Models</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Diagnostic Test: Test all<br/><b>Sponsors</b>:  <br/>
Elizabeth Glaser Pediatric AIDS Foundation;   UNITAID;   Kenya Ministry of Health;   Ministry of Public Health, Cameroon<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pulmonary Rehabilitation Program With Pulsed Electromagnetic Field Therapy in Patients With Post-covid Sequelae.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Device: Pulsed ectromagnetid field therapy;   Other: Pulmonary rehabilitation program (PRP)<br/><b>Sponsor</b>:   University of Malaga<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Paxlovid in the Treatment of COVID-19 Patients With Uremia</strong> - <b>Conditions</b>:   COVID-19;   Uremia<br/><b>Interventions</b>:   Drug: Paxlovid;   Drug: standard-of-care<br/><b>Sponsor</b>:   Ruijin Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Telemedically Assisted Sampling of COVID-19 Patients - Is the Sampling Quality Sufficient</strong> - <b>Conditions</b>:   Telemedicine;   Pharynx;   COVID-19<br/><b>Intervention</b>:   Diagnostic Test: telemedically guided oropharyngeal + nasal (OP+N) self-sampling (GSS) and nasopharyngeal (NP) or OP+N sampling performed by health care professionals (HCP)<br/><b>Sponsor</b>:   Teststation Praxis Dr. med Bielecki<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Improving Pediatric COVID-19 Vaccine Uptake Using an mHealth Tool</strong> - <b>Conditions</b>:   COVID-19 Vaccines;   Telemedicine;   Vaccine Hesitancy;   Pediatric ALL<br/><b>Interventions</b>:   Behavioral: COVID-19 Vaccine Uptake App;   Other: General Health App<br/><b>Sponsors</b>:  <br/>
University of Arkansas;   National Institutes of Health (NIH);   University of Nebraska;   University of Montana<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and practicality of high dose inhaled nitric oxide in emergency department COVID-19 patients</strong> - CONCLUSION: A single dose of iNO at 250 ppm was practical and not associated with any significant adverse effects when administered in the ED by emergency physicians. Local disease control led to early study closure and prevented complete testing of COVID-19 safety and treatment outcomes measures.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study</strong> - Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retrospective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys^(®) anti-SARS-CoV-2 S and the cPass™ SARS- CoV-2 Neutralization…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Network pharmacology and experimental validation identify the potential mechanism of sophocarpine for COVID-19</strong> - Introduction. Coronavirus disease 2019 (COVID-19) has caused a serious threat to public health worldwide, and there is currently no effective therapeutic strategy for treating COVID-19.Hypothesis/Gap Statement. We propose that sophocarpine (SOP) might have potential therapeutic effects on COVID-19 through inhibiting the cytokine storm and the nuclear factor NF-κB signalling pathway.Aim. The objective was to elucidate the potential mechanism of SOP against COVID-19 through a network pharmacology…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation</strong> - AXL, a TAM receptor tyrosine kinase (RTK), and its ligand growth arrest-specific 6 (GAS6) are implicated in cancer metastasis and drug resistance, and cellular entry of viruses. Given this, AXL is an attractive therapeutic target, and its inhibitors are being tested in cancer and COVID-19 clinical trials. Still, astonishingly little is known about intracellular mechanisms that control its function. Here, we characterized endocytosis of AXL, a process known to regulate intracellular functions of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of Antiviral Effect against SARS-CoV-2 Propagation by Crude Polysaccharides from Seaweed and Abalone Viscera In Vitro</strong> - Crude polysaccharides, extracted from two seaweed species (Hizikia fusiforme and Sargassum horneri) and Haliotis discus hannai (abalone) viscera, were evaluated for their inhibitory effect against SARS-CoV-2 propagation. Plaque titration revealed that these crude polysaccharides efficiently inhibited SARS-CoV-2 propagation with IC(50) values ranging from 0.35 to 4.37 μg/mL. The crude polysaccharide of H. fusiforme showed the strongest antiviral effect, with IC(50) of 0.35 μg/mL, followed by S….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Multifaceted efficacy of caspofungin against fungal infections in COVID-19 patients</strong> - Fungal co-infections of coronavirus disease 2019 (COVID-19) are generally infrequent, but are more common among patients with hematological diseases or severe cases in the intensive care unit (ICU). As fungal infections often carry a high mortality rate, preventing their development is considered important for patients with COVID-19. Caspofungin covers Candida spp. and Aspergillus spp. as causative pathogens of fungal infections associated with COVID-19, and is known to have few side effects…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and <em>in vitro</em> Studies</strong> - The pandemic caused by SARS-CoV-2 (SCoV-2) has impacted the world in many ways and the virus continues to evolve and produce novel variants with the ability to cause frequent global outbreaks. Although the advent of the vaccines abated the global burden, they were not effective against all the variants of SCoV-2. This trend warrants shifting the focus on the development of small molecules targeting the crucial proteins of the viral replication machinery as effective therapeutic solutions. The…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia</strong> - During the COVID-19 pandemic, vaccination is the most important countermeasure. Pharmacovigilance concerns however emerged with very rare, but potentially disastrous thrombotic complications following vaccination with ChAdOx1. Platelet factor-4 antibody mediated vaccine-induced immune thrombotic thrombocytopenia (VITT) was described as an underlying mechanism of these thrombotic events. Recent work moreover suggests that mechanisms of immunothrombosis including neutrophil extracellular trap…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5</strong> - Serine Incorporator 5 (SERINC5), a cellular multipass transmembrane protein that is involved in sphingolipid and phosphatydilserine biogenesis, potently restricts a number of retroviruses, including Human Immunodeficiency Virus (HIV). SERINC5 is incorporated in the budding virions leading to the inhibition of virus infectivity. In turn, retroviruses, including HIV, encode factors that counteract the antiviral effect of SERINC5. While SERINC5 has been well studied in retroviruses, little is known…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Type-I interferons in the immunopathogenesis and treatment of Coronavirus disease 2019</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is currently the major global health problem. Still, it continues to infect people globally and up to the end of February 2022, over 436 million confirmed cases of COVID-19, including 5.95 million deaths, were reported to the world health organization (WHO). No specific treatment is currently available for COVID-19, and the discovery of effective therapeutics requires…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Multi-target potential of Indian phytochemicals against SARS-CoV-2: A docking, molecular dynamics and MM-GBSA approach extended to Omicron B.1.1.529</strong> - CONCLUSION: Overall our study imparts the usage of phytochemicals as antiviral agents for SARS-CoV-2 infection. Additional in vitro and in vivo testing of these phytochemicals is required to confirm their potency.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring the Spike-hACE 2 Residue-Residue Interaction in Human Coronaviruses SARS-CoV-2, SARS-CoV, and HCoV-NL63</strong> - Coronaviruses (CoVs) have been responsible for three major outbreaks since the beginning of the 21st century, and the emergence of the recent COVID-19 pandemic has resulted in considerable efforts to design new therapies against coronaviruses. Thus, it is crucial to understand the structural features of their major proteins related to the virus- host interaction. Several studies have shown that from the seven known CoV human pathogens, three of them use the human Angiotensin-Converting Enzyme 2…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Monoclonal antibody designed for SARS-nCoV-2 spike protein of receptor binding domain on antigenic targeted epitopes for inhibition to prevent viral entry</strong> - SARS, or severe acute respiratory syndrome, is caused by a novel coronavirus (COVID-19). This situation has compelled many pharmaceutical R&amp;D companies and public health research sectors to focus their efforts on developing effective therapeutics. SARS-nCoV-2 was chosen as a protein spike to targeted monoclonal antibodies and therapeutics for prevention and treatment. Deep mutational scanning created a monoclonal antibody to characterize the effects of mutations in a variable antibody fragment…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Strategies to Improve Perioperative Communication During the COVID-19 Pandemic</strong> - The coronavirus disease 2019 pandemic has led to a variety of challenges that have necessitated process changes in perioperative environments. Communication failures are a cause of surgical adverse events, and the pandemic has created additional communication concerns. Measures to prevent disease transmission, such as social distancing and wearing personal protective equipment, may inhibit communication. Relational dynamics and the types of collaboration that perioperative health care…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pnictogen-Centered Cascade Exchangers for Thiol-Mediated Uptake: As(III)-, Sb(III)-, and Bi(III)-Expanded Cyclic Disulfides as Inhibitors of Cytosolic Delivery and Viral Entry</strong> - Dynamic covalent exchange cascades with cellular thiols are of interest to deliver substrates to the cytosol and to inhibit the entry of viruses. The best transporters and inhibitors known today are cyclic cascade exchangers (CAXs), producing a new exchanger with every exchange, mostly cyclic oligochalcogenides, particularly disulfides. The objective of this study was to expand the dynamic covalent chalcogen exchange cascades in thiol-mediated uptake by inserting pnictogen relays. A family of…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How to Prevent Gun Massacres? Look Around the World</strong> - Australia, Britain, Canada, and other countries have enacted reforms that turned mass shootings into rare, aberrational events rather than everyday occurrences. - <a href="https://www.newyorker.com/news/our-columnists/how-to-prevent-gun-massacres-look-around-the-world">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Will an Emergency Law Used to Keep Out Migrants Become Permanent?</strong> - At the start of the pandemic, the Trump Administration invoked an obscure provision called Title 42 to effectively stop migration. Even as other COVID restrictions are lifted, anti-immigration politicians insist that it remain in place. - <a href="https://www.newyorker.com/news/letter-from-the-southwest/will-an-emergency-law-used-to-keep-out-migrants-%20become-permanent">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>America’s Redistricting Process Is Breaking Democracy</strong> - Democrats have tried to keep up with Republican gerrymandering—and everyone is losing. - <a href="https://www.newyorker.com/news/the-political-scene/americas-redistricting-process-is-breaking-democracy">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Baby-Formula Blame Game</strong> - At a House committee hearing this week, the F.D.A. and Abbott passed the buck. With parents scrambling to feed their children, who’s responsible for the shortages? - <a href="https://www.newyorker.com/news/daily-comment/the-baby-formula-blame-game">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What Makes a Mass Shooter?</strong> - The authors of “The Violence Project” note that mass shootings have risen alongside overdoses and other deaths of despair—which is not a coincidence. - <a href="https://www.newyorker.com/podcast/the-new-yorker-radio-hour/what-makes-a-mass-shooter">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The best $17.59 I’ve ever spent: A totally normal alarm clock</strong> -
<figure>
<img alt="Illustration of digital alarm clock displaying 10 o’clock." src="https://cdn.vox-
cdn.com/thumbor/sx0e-l48Wd3TSVTAYhXxcfvJvOA=/500x0:3500x2250/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70920026/Clock_Radio.0.jpg"/>
<figcaption>
One writer’s journey to an unsexy and utilitarian alarm clock. | Dana Rodriguez for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I figured that maybe I was hopeless, but my third try at being an alarm clock person actually worked.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lfrGkU">
At the beginning of the movie <em>Freaky Friday </em>(2003), the mom character (Jamie Lee Curtis) pulls on the feet of her daughter (Lindsay Lohan) as she clings to the bars on her bed’s headboard. An alarm clock blares as they start their day with a battle of physical and mental wills. The bedside clock is small and black, with loud red digits. Its face reads 6:00 as it shrieks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ggz9DE">
When I was in high school, I too engaged in a battle of wills each day with my mother and my alarm clock. My mom didn’t yank my feet, though. “I would put my face right down by your head and whisper in your ear and (try to) kiss your cheek,” she recalled in a recent text message. That annoyed me so much that I would eventually relent and get up. (I now find it sweet.) I remember lying in bed before school picturing this “Freaky Friday” scene, wondering what my life would be like if I had a headboard.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YU4ER5">
I have never loved waking up early. Though I recognize that it’s virtuous in some slices of our culture to wake up at dawn to rise and grind, I prefer not to do that. I famously slept through my last morning of high school. I generally strive to be responsible and on time, but waking up — especially when my apparently powerful internal clock tells me it’s not time — has historically been a challenge for me.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3zxrL5">
During the pandemic it became that much more challenging. My time became silky and slick, like an eel determined to elude my grasp. I had nowhere to be any day. I let myself sleep in later and later in the name of self-care. Each night, I went to bed early. Each morning, I woke up right before my workday needed to start. As time went on, I started to wonder if maybe I wasn’t being a little too kind to myself. Maybe I would feel better if I got up at a regular time each day and didn’t spend the 30+ minutes before and after sleep funneling blue light into my eye bulbs via my phone.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VuzTdj">
I recalled reading about how Arianna Huffington, a paragon of hustle culture, recommended tucking your phone into its own designated bed each night. Her company, Thrive, called this product a “<a href="https://medium.com/thrive-global/introducing-the-phone-bed-93bf6cd275be">family bed,</a>” as it can charge up to 10 devices at once. The phones, sleeping head to toe, resemble Charlie’s grandparents in <em>Willy Wonka &amp; the Chocolate Factory</em>.
</p>
<div class="c-float-right">
<aside id="vAfofm">
<q>My time became silky and slick, like an eel determined to elude my grasp</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aCE9Nt">
The phone bed <a href="https://thrivephonebed.com/products/phone-bed">can be purchased</a> for $65 — down from its original price of $100 — on Thrive’s website. It is mini and made of wood, with white sheets and velvet and satin lining. A couple months into the pandemic, I was almost tempted to get one. I had started to dread my weekly Screen Time updates. I shielded my eyes each Sunday from the unimpeachable evidence of my minutes and hours squandered. If a calm night of sleep away from the chaos of the phone could be bought, who was I to say no?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ieZXVJ">
In the end, I could not justify the phone bed. I realized I could just put my phone in a drawer for free. And while the phone bed sort of solved one problem, it didn’t solve the more immediate one: that I would need a device to wake me up if I actually wanted to sleep away from my phone.
</p>
<hr class="p-entry-hr" id="cdZGeU"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="O5c9ef">
In May of 2020, my boyfriend kindly bought me a more straightforward solution: a normal alarm clock. I started plugging in my phone in the living room each night, setting the alarm in my room, and waking up to a hideous screeching blare each morning. I felt good!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cz911g">
After about a year, this clock sort of stopped working. Either that, or my body again became too powerful. I started sleeping through the alarm, once waking up disoriented at 8:58 before a 9 am meeting. I brought my phone back into my room as a backup alarm, which sort of defeated the purpose of the whole enterprise.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Qp2k9A">
I decided to try again with a new, nicer alarm clock. I splurged on a fancy Swiss quartz clock with excellent reviews. I found that this clock’s alarm was soft, elegant, and tasteful — and therefore useless to me. A delicate chime does not rouse me from my reverie. I require a screech. I brought my phone back into my room.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IdUXd5">
After that second failure, I figured that maybe I was hopeless. I had already made two earnest attempts at — and spent some money on — trying to be an alarm clock person. Maybe, I thought, I should resign myself to blue light and scrolling.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ar0Faj">
I sheepishly set up stricter screen time limits on my iPhone — in a moment of ambition and/or delusion, I set my Twitter limit to 15 minutes a day. As I scrolled in bed, the hourglass would pop up on my screen as an on-the-nose reminder of the passage of time, of my one wild and precious life slipping away from me in 15-minute intervals. (Apple apparently resisted using the hourglass image for a <a href="https://www.theatlantic.com/technology/archive/2019/09/why-apple-
screen-time-mostly-makes-things-worse/597397/">long time</a> because they thought users wouldn’t know what it meant. I know what it means! I can waste all the time I want and the sands will keep flowing.)
</p>
<div class="c-float- right">
<aside id="Vwxuxu">
<q>The prospect of hearing more of its beeps before coffee is a true deterrent. I love it.</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7TmNec">
As the months dragged on without an alarm clock and I waded deeper into my phone each night — into Instagram highlights of random people’s moms and Wikipedia rabbit holes about the ex-husbands of various celebrities — the more I felt I needed to give an alarm clock at least one more try.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nvQtRI">
So last September, I took myself to my local hardware store and asked the sales clerk at the front if I could “see” the clock radio above the register. She didn’t know what I was talking about. I pointed to it. She said that she had never seen anyone buy one, but she got it down for me. I took it from her and went, “Hmm.” She said that I could always return it later if I didn’t like it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5wxZf6">
I bought it! For $17.59 I had a new, normal alarm clock radio. It has a little black AM/FM cable that reminds me of a rat tail, a removable power cord, and loud, red digits that tell me the time.
</p>
<hr class="p-entry-hr" id="49kE7H"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kDLzpl">
My third clock is assertively not the Wirecutter recommended pick. It’s unsexy and utilitarian. It has two alarm settings. I can make a beep go off on AL-1, then get a local radio station blasting via AL-2 a few minutes later. I can snooze it many times — though I find I wish to less and less lately. The prospect of hearing more of its beeps before coffee is a true deterrent. I love it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Idvl2F">
This object hasn’t been without its challenges. For the first few weeks I had it, I couldn’t figure out how to turn off the alarm. So I unplugged it each morning and reset it each night. I <a href="https://www.nybooks.com/articles/2021/09/23/toll-of-the-clock/">read recently</a> that, “Before electricity, London clockmakers used to send assistants to the Greenwich observatory with pocket watches to get the exact time and bring it back, like hot soup in a takeout container.” I felt like one of those soup assistants as I flipped between my phone clock and my new clock, trying to align the latter to the exact right time.
</p>
<div>
<aside id="LAwtHM">
<q>The clock keeps moving even if I don’t feel like it. It reflects a socially agreed-upon version of reality.</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gjOVai">
The constant resetting was a pain, but also an opportunity to reflect on the nature of time, and how I have ultimate power to control how it is distributed (via this clock) but not how it flows onward (everywhere else). I was tickled by the feeling that I got to decide what time it was.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m5smtG">
Time only moves one direction on my alarm clock, as in life. It is humbling to know that if I miss my target minute, I have to go all the way back through all the possible times again. The gulf between 2:59 and 3 is vast, as is that between 8:05 and 8:04.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6Qy4Bl">
As I unplug and reset, I contemplate time and what I know about it. Time is money. Time is up. A flat circle. Of the essence. It’s also an imposed system. An instrument of social control! A benchmark for productivity. A commodity. A social contract. A scourge. A metaphor. A philosophical conundrum. The bedrock of capitalism. “<a href="https://www.google.com/books/edition/Technics_and_Civilization/PU7PktesGUoC?hl=en&amp;gbpv=1&amp;bsq=key%20machine">The key-machine of the modern industrial age</a>.” It is both naturally occurring (see: the sun, “biological clock”) and constructed by humans. It flies when we’re having fun, and weirdly compresses and blooms and clusters and disperses when we are two years into a pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7MTCZQ">
My little clock holds all of this (sort of)! And I get to set it! That is a wonder to me. James Gleick, a science journalist, <a href="https://www.nybooks.com/articles/2021/09/23/toll-
of-the-clock/">wrote</a> last year that “Far from anchoring us in time, clocks cast us loose from the past, dislocate us from our natural sensation of continuity.” To him, clocks make visible each moment replacing the prior. The clock keeps moving even if I don’t feel like it. It reflects a socially agreed-upon version of reality. I am glad to be an active participant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6KFAQJ">
My alarm clock is rich: It is a locus of metaphor and dislocation and social history imbued with unique power. But it’s also just a cheap device from the hardware store. I’m happy that it wakes me up.
</p></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VkeWfi">
After weeks of resetting my clock, I eventually just read the paper instruction manual that came in the box. I learned how to operate the device properly. It was actually very simple.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7xEcyP">
<em>Lora Kelley is on the editorial staff of The New York Times Opinion section.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="06TtzY">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D0zqD8">
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The philosopher who resisted despair</strong> -
<figure>
<img alt="" src="https://cdn.vox-
cdn.com/thumbor/hKL7_jz2E_EqW8q383h7hDzU0MQ=/66x0:2611x1909/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70919953/GettyImages_478449242a.0.jpg"/>
<figcaption>
Albert Camus in Paris, France, in 1959. | Daniel Fallot/INA via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Albert Camus and the search for solace in a cruel age.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xdYAHR">
In March 1946, the French philosopher and novelist Albert Camus sailed across the Atlantic to deliver a speech at Columbia University. It was his first and only trip to America. Camus had achieved worldwide fame with the publication of his 1942 novel, <em>The Stranger,</em> and his stature as an artist and a member of the French resistance had grown considerably over the course of the war.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0CX8IL">
The Nazis had been defeated the year before and there was a belief that some kind of final victory over fascism had been achieved. But in his address, Camus did not oblige that sentiment. The philosopher, who was expected to talk about French theater and philosophy, lingered on the pathologies that produced Nazism. He went further, arguing that the postwar world had fallen into complacency.<strong> </strong>The war was over but a certain kind of plague persisted:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8RZmVh">
Contemporary man tends more and more to put between himself and nature an abstract and complex machinery that casts him into solitude. … With so much paper, so many offices and functionaries, we are creating a world in which human warmth has disappeared. Where no one can come into contact with anyone else except across a maze of what we call formalities.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9YRtCf">
The point of the talk was to say that the entire Western world lived in a civilization that elevated abstractions over experience — that ultimately removed people from the reality of human suffering.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t165Y0">
I doubt Camus would change his posture were he to give that talk today. The world of 2022 is different from the world of Nazi barbarity Camus was reacting against, but it’s not as different as we would hope. A great power in Europe is trying to conquer a weaker power driven by some claim to historical greatness and a notion of its geopolitical primacy. It’s hard to look at the images of bombed-out apartment buildings and mass graves in Ukraine and not think of Europe in the aftermath of WWII.<strong> </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Tva5cz">
Camus’s earlier work, when he was writing books like <em>The Stranger</em> and <em>The Myth of Sisyphus</em>, was<strong> </strong>more about the strangeness of the human experience. But his oeuvre took a turn as he witnessed the horrors of the war, his attention fixed on the ways in which people justify violence and lawlessness. Indeed, Camus’s whole philosophy became a response to human brutality, and that’s what makes him such an essential voice at this historical moment.
</p>
<div id="c149QK">
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rPyaN8">
</p>
<h3 id="qM1VMO">
Against abstraction
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hGcU67">
Camus was one of the intellectual stars of midcentury Paris. But unlike contemporaries like Jean-Paul Sartre and Simone de Beauvoir, he was always an outsider. Most everyone in that milieu went to one of the elite universities, like the Sorbonne or the École normale supérieure. Camus grew up in a working-class neighborhood in French Algeria and went to a public university.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pEdMFZ">
He was raised as a French citizen in Algeria, where most of the inhabitants were indigenous Arabs and Berbers who had lived there<strong> </strong>for centuries before the French showed up. Living as a French citizen in a colonized state helped give shape to his philosophy and politics. He loved the French people who were born in Algeria and made a home there, but he was also outraged by the treatment of Arabs and Berbers — hundreds of thousands of whom were killed by French forces <strong>— </strong>and spent years condemning it as a young reporter for a left-wing newspaper.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SS4xFR">
The Algerian experience made Camus wary of either-or approaches to politics. Having witnessed the extremism on both sides — French occupiers and their Arab resisters — and the cycles of violence and retaliation, he was determined to find a space for dialogue, or at least impose limits on the killing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gjKh5Y">
No one, he insisted, had a monopoly on truth or justice. “I want Arab militants to preserve the justice of their cause by condemning the massacres of civilians, just as I want the French to protect their rights and their future by openly condemning the massacres of the repression.” He was widely mocked as a moderate for this stance (even as he lobbied behind the scenes on behalf of countless political prisoners during Algeria’s war for independence). I’m not sure Camus ever had an adequate response to the criticisms. The best he could muster was to say that the goal was to stop the spiral of violence and retaliation and that meant condemning the sorts of tactics that made resolution impossible.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2D8byQ">
In the spring of 1940, shortly after Camus had moved to Paris, the Germans invaded France. He tried to enlist in the army but was declined due to an early bout of tuberculosis. He instead became the editor of the French resistance newspaper, Combat, and produced some of his best work as a columnist there. It’s really that period that crystallized so much of his thinking.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g0WYJf">
From the start of the war, Camus was preoccupied with the hazards of ideological politics and abstract ideals. “It was impossible,” he wrote, “to persuade people who were doing these things not to do them because they were sure of themselves and because there is no way to persuade an abstraction, or, to put it another way, the representative of an ideology.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NKuuiO">
This is what he saw in Nazism: a political plague that obeyed its own implacable logic and destroyed the hosts — and everyone else. Beyond that specter, he could sense the impending battle between capitalist and Marxist ideologies, both of which, in their own ways, were based on unchallengeable ideas of progress.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EoVl9T">
After the war, Camus’s philosophical work became even more political. He published his book-length essay <em>The Rebel</em> in 1951, which precipitated his public fallout with Sartre. Camus condemned the excesses on both sides of the Cold War — a stance that alienated Marxists like Sartre — but he was always interested in closing the gap between theory and action:
</p></li>
</ul>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zh4Eoq">
The purpose of this essay is once again to face the reality of the present, which is logical crime, and to examine meticulously the arguments by which it is justified. … One might think that a period which, in a space of fifty years, uproots, enslaves, or kills seventy million human beings should be condemned out of hand. But its culpability must still be understood.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nwb5U6">
<em>The Rebel</em> is a flawed book, and it does, at times, feel too removed from historical realities. But the weaknesses of the book reflect the doubt at the core of Camus’s political philosophy. It wasn’t about drawing some kind of moral equivalence between fascism and communism. It was an attempt to understand a peculiar form of nihilism that had come to dominate the 20th century.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QzQ6n0">
For Camus, nihilism wasn’t so much about belief in nothing; it was about refusing to believe in the world as it is. And killing in service to some idea is just as nihilistic as believing that nothing is true and therefore everything is permitted.
</p>
<h3 id="shVzVq">
The persistence of compassion
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xlhlZJ">
That human tendency toward nihilism was on Camus’s mind when he spoke at Columbia in 1946. “Nihilism has been replaced by absolute rationalism,” Camus said, “and in both cases, the results are the same.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vtXbhK">
The upshot of Camus’s speech at Columbia was to take all the anguish over the atrocities of World War II and turn it into something ennobling. It’s natural to be indignant in the face of such horror, but there was a sliver of consolation here. Camus asks us to reflect on that common outrage, realize what it says about the value of human life, and commit to being a more engaged human being.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sdMpFG">
Camus’s 1947 novel <em>The Plague </em>is all about our shared vulnerability to<em> </em>loss and suffering. Something like a pandemic sweeps into our lives and disrupts our reality. The routines, the diversions, the daily comforts — it all explodes under the intensity of emergency. Suddenly, everyone is facing the same situation and there’s nothing to do but resist. “I know it’s an absurd situation,” the protagonist Rieux says at one point, “but we’re all involved in it, and we’ve got to accept it as it is.”<strong> </strong>The same is true of war (Camus himself insisted that the plague in the novel was an allegory for the Nazi occupation).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GypkWO">
Camus has been much on my mind these last few months. The great irony of Putin’s war is that it seems to have reinforced the very thing it was <a href="https://www.businessinsider.com/putin-denies-reviving-russian-empire-says-ukraine-not-real-
country-2022-2">intended to destroy</a>: the Ukrainian identity. In <em>The Rebel</em>, Camus says we can see the roots of human solidarity in moments of crisis, when people have to resist what’s taking place, whether it’s a biological plague or a military occupation. And when that happens, we look around and see others doing the same thing. We see others saying “no” and “yes” at the same time — no to the destruction of human life, yes to the community that emerges out of that refusal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8IMqJE">
Amid the horror is solace — there’s something deeply satisfying about doing things in the world with other people. The immediacy of a war or a natural disaster collapses the barriers between us because it’s so clear what has to be done. And while nothing redeems a tragedy, there’s at least some comfort in the solidarity that emerges from it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LzYp7d">
The problem is that solidarity often slips away in the mechanics of everyday life. But the empathy and love fueling that desire to help in a crisis is a constant possibility. Camus thought this didn’t happen automatically — it was a choice we each had to make — and that we could carry the spirit of collective action into the post-crisis world. He also thought that acting with other people, caring about other people, made us happy and was thus an antidote to despair.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pDsCG3">
The striking thing about Camus is that he imagines life itself as a kind of emergency in the sense that it can end at any moment. The decision to live in spite of that awareness carries a moral obligation: to not add to the already random suffering in the world. Seeing that principle transgressed has a way of renewing our commitment to it.
</p>
<h3 id="H2UGLB">
The antidote to despair
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ds2aPW">
Camus always said that he was pessimistic about the human condition and optimistic about humankind. Maybe that’s a contradiction. But I always thought the deeper point was much simpler: We’re born into a world that doesn’t seem to have any purpose, that we know will end, and yet we go on living anyway.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ajdh62">
For Camus, that meant that there is something in humanity that transcends the fact of our condition. That’s the source of our collective dignity — and it’s the part of humanity that always has to be defended.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uECfEE">
This can all sound a bit abstract from a distance. What’s the average person supposed to do about all the horrors in the world? You can look anywhere — from the conflicts in Ukraine and Yemen and Syria to the barbarity of mass shootings in places like <a href="https://www.vox.com/policy-and-politics/23140441/uvalde-shooting-robb-elementary-school-texas">Uvalde, Texas</a> — and be horrified by the suffering, but you can’t do anything about it.<strong> </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yJiZVn">
That outrage you feel, though — that’s the spark of common humanity that Camus was always affirming.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DxInLl">
At the end of his speech, he told the audience that their job was to take that spark and commit to being a more attentive human being. That meant seeing people as people, not as abstractions or obstacles. It meant not letting our ideas about the world become more important than our experience of the world.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xVSKUd">
Camus always returned to the myth of Sisyphus as the model of human defiance. The problem wasn’t that Sisyphus had to roll his boulder up a hill forever; it’s that he had to roll it alone. His point was that we’re all rolling our boulders up a hill, and that life is most meaningful when we push together.
</p>
<ul>
<li><strong>Stop scolding people for worrying about monkeypox</strong> -
<figure>
<img alt="Monkeypox virus detection in Indonesia" src="https://cdn.vox-
cdn.com/thumbor/AK1t5jJ2cxnASushiZSlDnihVKM=/214x0:3627x2560/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70919901/1144024287.0.jpg"/>
<figcaption>
A sign in an international airport in Jakarta, Indonesia warns passengers about identifying monkeypox, endemic to parts of Central and Western Africa but now spreading worldwide. | Jepayona Delita/Future Publishing via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The obsession with managing public opinion gets in the way of managing public health.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J3jVHp">
In the past few weeks, <a href="https://ourworldindata.org/monkeypox">more than 350 cases of monkeypox</a> — a viral disease that’s a much milder cousin of smallpox — have been reported in <a href="https://apnews.com/article/health-united-nations-
epidemics-world-organization-5f502a613163d5c71e5bd7130eba3a03">more than 20 countries</a> worldwide. That’s a surprise, and an unpleasant one. Monkeypox has surfaced periodically in the Congo Basin and in West Africa since <a href="https://www.cdc.gov/poxvirus/monkeypox/index.html#:~:text=Monkeypox%20was%20first%20discovered%20in,intensified%20effort%20to%20eliminate%20smallpox.">its discovery in the 1950s,</a> but past outbreaks haven’t involved cases in this many countries, or this degree of apparent person-to-person spread.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VdudmQ">
Still, because as far as we know from past outbreaks monkeypox usually isn’t very contagious and a good vaccine already exists, it ought to be possible to <a href="https://www.vox.com/science-and-health/23140315/contain-public-health-epidemic-vaccine-monkeypox-outbreak">contain even this apparently larger outbreak</a>. Hence many public health officials have emphasized, in their communications about monkeypox, that people shouldn’t worry or overreact.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gs0gdt">
Panic is never a good public health strategy, but in attempting to preemptively tamp down public fear, I think experts are failing to learn one of the most important lessons of Covid-19: that we’re too afraid of “alarmism” when outbreaks hit, and should spend less time telling people not to overreact and more time telling them what’s actually going on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WCYtcw">
The impulse on the part of the public health community<strong> </strong>to try to<strong> </strong>manage public emotion — rather than provide the public with facts — has dogged us throughout the pandemic, often making it harder to make good decisions. Assurances that <a href="https://www.nytimes.com/2020/03/17/opinion/coronavirus-face-masks.html">people didn’t need masks</a>, meant to protect the supply for health care workers, lastingly damaged trust and masking rates. The CDC’s initial decision <a href="https://www.npr.org/2021/08/12/1027198500/the-potential-implications-of-not-tracking-
breakthrough-cases">not to track breakthrough infections</a> — seemingly meant to show confidence in the vaccines — made it harder to tell how long vaccine-based immunity lasted.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7IzTJs">
There are some solid epidemiological reasons to conclude that monkeypox doesn’t pose the same threat to the world that Covid-19 did in 2020. But instead of condemning alarmism, experts should acknowledge the many reasons for that alarm. The world is <a href="https://www.vox.com/23001426/pandemic-proof">horribly vulnerable to the next pandemic</a>, we know it will hit at some point, and the undetected spread of monkeypox around the world until there were dozens of cases in non-endemic countries — despite the fact it typically has low transmissibility — shows how profoundly we’ve failed to learn the lessons from Covid-19 we need to avoid a catastrophic repeat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hpDkqH">
Experts should focus more on communicating what they know about monkeypox, pandemics, and the fragility of our current system, aiming to tell people what they can do and the policies they can support in response to their justified fear — instead of preemptively warning against “panic.”
</p>
<h3 id="HZ5pug">
Monkeypox, explained
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iAItGI">
Monkeypox was first identified in research animals in the 1950s, and can cause flu-like symptoms and a <a href="https://www.cdc.gov/poxvirus/monkeypox/clinicians/clinical-recognition.html">characteristic rash with round red blisters </a>all over the body when it infects unprotected humans. The fatality rate has historically ranged from zero to <a href="https://www.who.int/news-room/fact-sheets/detail/monkeypox">11 percent</a>, according to the World Health Organization.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GAQjwx">
For decades, outbreaks among humans were rare, in significant part because the smallpox vaccine protects against monkeypox, and <a href="https://www.usatoday.com/story/news/factcheck/2021/01/12/fact-
check-vaccination-helped-eliminate-smallpox/4124284001/">smallpox vaccination was common</a>. In recent years, though, monkeypox cases have been on the rise as vaccination against smallpox, <a href="https://www.vox.com/future-
perfect/21493812/smallpox-eradication-vaccines-infectious-disease-covid-19">which was eradicated in 1979,</a> began to wane. <a href="https://www.cdc.gov/media/releases/2022/s0518-monkeypox-case.html">According to the CDC, Nigeria has reported 450 monkeypox cases since 2017</a> — not a lot, but a significant increase from case rates in previous decades.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YF4whD">
Despite that rise and the more recent spread to new countries, there’s reason for optimism that we can prevent a large-scale pandemic of monkeypox. While the variant causing the current outbreaks isn’t fully understood, and we should not rule out that the virus is substantially more transmissible than we’re used to, the disease in general is a known quantity. Even under pessimistic assumptions about the transmissibility of this new variant, it is much less transmissible than the coronavirus that causes Covid-19, which originally had an R0 of 2-3 and now has an R0 of 8-10 for people without preexisting immunity. Unlike Covid-19, monkeypox is thought to be only contagious while patients are symptomatic, which provides additional reason for optimism about containment.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZxIvBX">
But optimism should not equal complacency.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QWO0Dm">
A large international outbreak of a disease that was previously thought to be very hard to transmit person-to-person is bad news, period. There are still a lot of unknowns here, and until we know exactly what happened and have slowed the growth of new cases<strong>, </strong>the chance of this variant of monkeypox being substantially more transmissible — and hard to contain — is not so low that we can confidently assert that everything will be fine.
</p>
<h3 id="n2cMWC">
The lessons of Covid-19
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SfL2FZ">
Writing this article, I had an eerie sense of déjà vu. I <a href="https://www.vox.com/future-
perfect/2020/2/6/21121303/coronavirus-wuhan-panic-pandemic-outbreak">wrote a similar one</a> in early February of 2020, when Americans were just starting to hear about Covid-19. In that article, I rounded up some takes on the then very novel coronavirus that were in the headlines at the time:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sWQMNk">
“Don’t worry about the coronavirus. Worry about the flu,” <a href="https://www.buzzfeednews.com/article/danvergano/coronavirus-cases-deaths-
flu">BuzzFeed</a> argued. The flu “poses the bigger and more pressing peril,” the <a href="https://www.washingtonpost.com/health/time-for-a-reality-check-america-the-flu-is-a-much-bigger-threat-than-
coronavirus-for-now/2020/01/31/46a15166-4444-11ea-b5fc-eefa848cde99_story.html">Washington Post said</a>. “Why should we be afraid of something that has not killed people here in this country?” an epidemiologist argued in the <a href="https://www.latimes.com/california/story/2020-01-31/flu-coronavirus">LA Times</a>. <a href="https://www.wafb.com/2020/02/04/doctor-louisiana-residents-should-not-worry-about-flu-not-coronavirus/">Other</a> <a href="https://www.cleveland19.com/2020/01/29/worried-about-coronavirus-fear-flu-instead/">outlets</a> <a href="https://nationalpost.com/health/new-coronavirus-may-be-no-more-dangerous-than-the-flu-despite-worldwide-alarm-
experts">have</a> <a href="https://news.berkeley.edu/2020/02/04/coronavirus-not-something-to-panic-about-says-berkeley-
health-expert/">agreed</a>. An ex-White House health adviser has told Americans to “<a href="https://www.cnbc.com/2020/01/30/ezekiel-emanuel-on-coronavirus-americans-need-to-stop-panicking.html">stop panicking and being hysterical</a>.”
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ePeb47">
Bad call, I argued at the time. We didn’t know yet how transmissible the coronavirus was. We didn’t know if the early numbers out of China, where the first cases were recorded, were misleading. (It’s now believed they almost certainly were.) “That’s just far too much uncertainty to assure people that they have nothing to worry about,” I wrote. “And misleadingly assuring people that there’s nothing to worry about can end up doing harm.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0darVD">
Obviously, Covid-19 has done quite a lot of harm, to the tune of <a href="https://www.nytimes.com/live/2022/05/19/world/covid-19-mandates-vaccine-cases">more than 1 million dead</a> in the US alone. But we’re at risk of forgetting some of those major lessons from early 2020.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8X0lDe">
Last week, CNN <a href="https://www.cnn.com/2022/05/19/health/monkeypox-us-cases-cdc-investigation/index.html">quoted</a> the CDC’s Jennifer McQuiston, deputy director of the Division of High Consequence Pathogens and Pathology, as saying: “There really aren’t that many cases that are being reported — I think maybe a dozen, a couple dozen — so, the general public should not be concerned that they are at immediate risk for monkeypox.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k9EMpG">
This seems true, technically. Most Americans are not at immediate<em> </em>risk of exposure to monkeypox, just like in early February 2020 they weren’t at immediate risk of exposure to the coronavirus (there may have only been a few dozen cases in the US at that time). But this neglects the factor of exponential growth. The thing that’s <a href="https://rss.onlinelibrary.wiley.com/doi/full/10.1111/1740-9713.01401">scary about infectious disease</a> is that a few<em> </em>cases can rapidly become more cases, and eventually become lots<em> </em>of cases. Monkeypox probably isn’t very transmissible, but until we’ve actually contained it, we don’t know how easy it will be to contain, and the fact there aren’t very many cases yet just isn’t that reassuring.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FJfYPU">
“‘No reason for alarm’ is bad science as well as bad risk communication,” I quoted risk communications expert Peter Sandman as saying in that 2020 story. “Telling people not to worry about an emerging infectious disease because it isn’t a significant risk here and now is foolish. We want people to worry about measles when there’s very little measles around, so they will take the precaution of vaccinating their children before it’s imminently necessary. We want people to worry about retirement when they’re years away from retiring, so they will start saving now.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Qc71h">
Yet the impulse to focus on assuring Americans they shouldn’t panic about monkeypox is very much on display.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7mgvNd">
“There’s certainly no reason to panic,” Daniel Bausch, president of the American Society of Tropical Medicine &amp; Hygiene, told CNN. Reason ran an article titled <a href="https://reason.com/2022/05/23/dont-panic-over-monkeypox/">Don’t Panic Over Monkeypox</a>. “Don’t worry — at least about this,” Geoffrey Smith, a University of Cambridge poxvirus virologist, <a href="https://www.washingtonpost.com/business/monkeypox-isnt-looking-like-a-covid-sized-
threat/2022/05/23/0a6ebee0-dad3-11ec-bc35-a91d0a94923b_story.html">told the Washington Post</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bhnQer">
I agree with the more nuanced opinions each of these experts share when they’re given a bit more space to expound on their views. It’s straightforwardly true that monkeypox should be easier to contain with contact tracing and vaccination than Covid-19 was.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Z18R1y">
But everyone’s insistence on prefacing that nuance by<strong> </strong>telling me not to worry drives me nuts, and I think reflects a mistake in our thinking about pandemics.
</p>
<h3 id="neLWcX">
Being alarmed about pandemics is completely reasonable
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7VxVqB">
A fact that should not need saying in 2022: Pandemics cause immense human suffering and death. Even if a disease kills only one in 1,000 people who get sick with it, <a href="https://link.vox.com/view/608adc1091954c3cef027f33frnjc.n5e/7f43e626">if it hits a billion people worldwide, that’s a million dead</a>. Infectious disease has killed more people than any war in history, and experts keep on warning us that a pandemic much, much worse than Covid-19 is very much possible and really could happen.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JwA5LN">
The <a href="https://www.vox.com/coronavirus-covid19/2020/3/20/21184887/coronavirus-covid-19-spanish-flu-
pandemic-john-barry">1918 flu</a> was deadlier than Covid-19, and deadly in particular to healthy young people. A repeat would be devastating, and the world isn’t particularly prepared. Smallpox, when it existed, had an estimated 30 percent mortality rate. The US has vaccines stockpiled in case a lab accident, terrorist act, or bioweapon ever unleashes it on the world again, but vaccinating the whole world against a disease — as we’ve seen with Covid-19 — is hard to do as quickly as a contagious disease can move.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Nn74dv">
It’s not just diseases from<strong> </strong>nature, either. With <a href="https://www.vox.com/future-perfect/2018/12/6/18127430/superbugs-biotech-pathogens-biorisk-
pandemic">rapid advances in biological engineering</a>, it’s now entirely possible to make diseases that could put smallpox and the flu to shame. “Gain of function” work on making deadly diseases deadlier is ongoing. A small group of bad actors could unleash a virus that kills millions of people — and the systems in place to prevent that are limited, underresourced, and inadequate for the stakes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WPd7O2">
In that light, all the focus on telling people not to worry about monkeypox seems a little silly. There are genuine concerns about not crying wolf, about preserving credibility so that when you tell people ‘this is the big one’, they listen. But institutions that initially failed to say “this is the big one” about Covid-19 in February 2020 — and told us, instead, to worry about the flu — aren’t going to repair their damaged credibility by maintaining the same course.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9AW2tO">
The course I’d like to see them take instead is the one Sandman, the risk communications expert, recommended with Covid-19: “Instead of deriding people’s fears about the Wuhan coronavirus,” he <a href="http://www.psandman.com/articles/Corona1.htm">wrote</a>, “I would advise officials and reporters to focus more on the high likelihood that things will get worse and the not-so- small possibility that they will get much worse.”
</p>
<h3 id="FolsVf">
Taking “worry” off of center stage
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q7bsvn">
Many of the biggest missteps of the last few years have happened when our public health and communications institutions have tried to manage public reactions to what they have to say: from Fauci saying that <a href="https://slate.com/technology/2021/07/noble-lies-covid-fauci-cdc-masks.html">he dismissed mask-wearing</a> early on in the pandemic out of fears of causing mass panic, to worries that <a href="http://www.psandman.com/col/Corona58a.htm">endorsing booster shots</a> (even as the evidence grew they were needed) would make the vaccines look bad, to the FDA’s earlier seeming reluctance to authorize vaccines for children under age 5, despite data justifying it, out of concerns that authorizing Pfizer and Moderna at different times would <a href="https://www.nytimes.com/2022/04/29/briefing/vaccines-kids-moderna-pfizer.html">confuse the public</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xy6nQs">
In general, I’d like to see public health officials step back entirely from trying to manage our feelings about outbreaks. Don’t tell us to worry or not to worry, or not to worry yet. Don’t tell us to worry about something else instead. Tell us what measures are being taken to contain the monkeypox outbreak, and prevent the next monkeypox outbreak, and prevent the next outbreak of something much, much worse than monkeypox. By all means, explain the reasons to think monkeypox is likely not very transmissible; that’s important information you have relevant expertise on, unlike trying to manage the public’s feelings.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uAus1v">
And for its part, the media should stop asking public health officials “should I worry?” instead of asking them the questions they are much more equipped to answer: What policies would have prevented this outbreak? What measures need to be in place to contain it? What scenarios are plausible from here?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s7aQ6s">
In many cases, “don’t worry” is just being used as shorthand for “there’s good reason to think monkeypox won’t cause a global pandemic” — which, to be clear, is a true claim. But I think it’s worth spelling out the longer claim, rather than treating worry as the key consideration. People shouldn’t be encouraged to view outbreaks through the lens of “should I be scared?” but rather through the lens of “will this be contained, what will it take to contain it, and if it’s not contained, what effects will it have on the world?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pLJKfh">
Once you have the accurate facts about monkeypox — and about the risk of pandemics generally — whether you’re worried by those facts isn’t really a question for the CDC.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DFKT3X">
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bopanna, Middelkoop save five match points to knock out Wimbledon champions from Roland Garros</strong> - Bopana matched his best performance at the clay court major by reaching the quarterfinals, having done it four times in the past</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pete’s Dragon, Glow In The Dark, Serdar and Defining Power impress</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Preview | In its maiden IPL final, Gujarat Titans faces marauding Buttler’s Royals</strong> - Rajasthan Royals will look to the in-form Jos Buttler to inspire the team in its first IPL final since 2008, facing debutants Gujarat Titans, who have impressed by topping the table</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Liverpool to play for Ukraine people in Champions League final: Klopp</strong> - With the Champions League final between Liverpool and Real Madrid taking place in Paris instead of St. Petersburg because of Russia invasion of Ukraine, coach Jurgen Klopp has said his team is playing for Ukraine</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NBA Conference Finals | Jimmy Butler’s 47 points force Game 7 for Heat, Celtics</strong> - Miami Heat forward Jimmy Butler shook off his bad form to singlehandedly carry his team to a 111-103 victory over Boston Celtics to tie the NBA Eastern Conference Finals at 3-3</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A.P. SC Commission to allocate 2.5 acres of cultivable land to slain Dalit youth’s family</strong> - The youth was allegedly murdered by ruling party MLC on May 19</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Uttar Pradesh Budget a ‘deceit,’ says Lalji Verma; Finance Minister Suresh Khanna intervenes, asks him to keep facts right</strong> - The Yogi Adityanath government on May 26 presented its maiden Budget of the second term with a focus on education, employment, empowerment of women and farmers besides law and order.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘John Luther’ movie review: Jayasurya’s evenly-paced thriller falters only in the last act</strong> - Debutant director Abhijith Joseph, who also scripted the film, does not tread new ground, but is sure of what he is doing</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Thrikkakara byelection | No-holds-barred campaign ends today</strong> - The LDF and UDF left no stone unturned in their electioneering in Thrikkakara as it emerged as a battle of prestige between Chief Minister Pinarayi Vijayan and Leader of the Opposition V. D. Satheesan</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jharkhand CM Hemant Soren gets more time to appear before EC in mining lease case</strong> - Earlier, Mr. Soren was asked to appear before the Election Commission either in person or through his counsel on May 31</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Troops could quit Severodonetsk amid Russian advance - official</strong> - Russian forces are in part of Severodonetsk and could surround local troops, an official says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine conflict: The families living in an underground station for three months</strong> - Families who have been sheltering in a metro station since the start of the war now fear eviction.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Liverpool v Real Madrid: A heavyweight final</strong> - Liverpool will look to win European club football’s most prestigious prize for the seventh time when they face Real Madrid in a mouth-watering Champions League final in Paris on Saturday.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Severodonetsk: Ukrainian man cycles from besieged city, dodging Russian shells</strong> - Evading the Russian forces besieging Severodonetsk, a man cycled to safety amid bombs and shells.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Japanese Red Army founder Shigenobu freed after 20 years</strong> - Fusako Shigenobu, 76, was jailed for her part in a hostage siege at the French embassy in the Hague.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sony accelerates push into car sector in diversification drive</strong> - Wants to supply electric and autonomous vehicle sensors by 2025. - <a href="https://arstechnica.com/?p=1857027">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mining museums’ genomic treasures</strong> - Museums hold billions of biological specimens, many of which still contain DNA. - <a href="https://arstechnica.com/?p=1856930">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rethinking air conditioning amid climate change</strong> - ACs and refrigerators help keep people safe—but they also further warm the planet. - <a href="https://arstechnica.com/?p=1856893">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Are TikTok algorithms changing how people talk about suicide?</strong> - Social media users have adopted terms like “unalive” to avoid platform censorship. - <a href="https://arstechnica.com/?p=1857008">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>US college VPN credentials for sale on Russian crime forums, FBI says</strong> - Trafficked data could lead to subsequent attacks, agency warns. - <a href="https://arstechnica.com/?p=1857093">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Uvalde citizen gets pulled over</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A very cute blonde was pulled over for speeding by an Uvalde motorcycle officer. When he walked up to her window and opened his ticket book, she said, “I bet you’re going to sell me a ticket to the policeman’s Ball.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The cop replied, “No, ma’am. You’re thinking of the Border Patrol , the Uvalde Police don’t have balls.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Difficult_Antelope14"> /u/Difficult_Antelope14 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/uz6ynd/uvalde_citizen_gets_pulled_over/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/uz6ynd/uvalde_citizen_gets_pulled_over/">[comments]</a></span></p></li>
<li><strong>Studies say most stabbings are committed by someone close to the victim.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Within arm’s length, to be specific.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Sydniswans"> /u/Sydniswans </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/uzk8bk/studies_say_most_stabbings_are_committed_by/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/uzk8bk/studies_say_most_stabbings_are_committed_by/">[comments]</a></span></p></li>
<li><strong>How many Texas cops does it take to save children from an active shooter?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Still under investigation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
​
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
​
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
​
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Edit: For those who assume I think any part of this situation is funny… <a href="https://en.wikipedia.org/wiki/Black_comedy">https://en.wikipedia.org/wiki/Black_comedy</a>. Also who gave me a Wholesome award? That’s seriously messed up.
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Edit 2: For those claiming it’s “too soon”… I respectfully disagree, I think this is the perfect time. The pain won’t ever go away for those families - there will never be a time when they’ll think “Sure, it’s been long enough - go ahead and laugh about it.” However, the anger and shock felt by the general public will begin to fade as other news stories and other tragedies steal our attention. Better to elicit stronger emotions now and hopefully, in a tiny imperceptible way, increase the likelihood of meaningful change.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/yrthegood1staken"> /u/yrthegood1staken </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/uyvdk0/how_many_texas_cops_does_it_take_to_save_children/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/uyvdk0/how_many_texas_cops_does_it_take_to_save_children/">[comments]</a></span></p></li>
<li><strong>My attractive female neighbor is completely paranoid. She thinks I’m following or even stalking her</strong> - <!-- SC_OFF -->
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She is worried that I may be obsessed with her and any time she hears a noise in her house she is…purified? Oh, wait: petrified. Sorry, it’s not easy reading a diary through binoculars from a tree.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/fhqwhgadsz"> /u/fhqwhgadsz </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/uzl37n/my_attractive_female_neighbor_is_completely/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/uzl37n/my_attractive_female_neighbor_is_completely/">[comments]</a></span></p></li>
<li><strong>Why is it okay to have unprotected sex with an Uvalde police officer?</strong> - <!-- SC_OFF -->
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Because they never come inside.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/LiterallyAHippo"> /u/LiterallyAHippo </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/uyxuof/why_is_it_okay_to_have_unprotected_sex_with_an/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/uyxuof/why_is_it_okay_to_have_unprotected_sex_with_an/">[comments]</a></span></p></li>
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