Added daily report

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 <h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-preprints">From Preprints</a></li>
 <li><a href="#from-clinical-trials">From Clinical Trials</a></li>
 <li><a href="#from-pubmed">From PubMed</a></li>
 <li><a href="#from-patent-search">From Patent Search</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
 <ul>
 <li><strong>Containing the Spread of Infectious Disease on College Campuses</strong> -
 <div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 College campuses are highly vulnerable to infectious diseases outbreaks, and there is a mounting need to develop strategies that best mitigate their size and duration, particularly as colleges consider reopening their campuses in the midst of the COVID-19 pandemic. Towards addressing this need, we applied a stochastic transmission model to quantify the impact of university-level responses to past outbreaks on their campuses and used it to determine which control interventions are most effective. The model aims to simultaneously overcome three crucial issues: stochastic variation in small populations, missing or unobserved case data, and changes in disease transmission rates post-intervention. We tested the model and assessed various interventions using data from the 2014 and 2016 mumps outbreaks at Ohio State University and Harvard University, respectively. Our results suggest that universities should design more aggressive diagnostic procedures and stricter isolation policies to decrease infectious disease incidence on campus. Our model can be applied to data from other outbreaks in college campuses and similar small- population settings.
 </p>
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 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.07.31.20166348v3" target="_blank">Containing the Spread of Infectious Disease on College Campuses</a>
 </div></li>
 <li><strong>Propensity to reappraise promotes resilience to stress-induced negativity bias</strong> -
 <div>
 Stress exposure is associated with an increased tendency to appraise ambiguous social stimuli as negative. However, it remains unknown whether tendencies to use emotion regulation strategies—such as cognitive reappraisal, which involves altering the meaning of affective stimuli—can buffer these stress effects on social evaluations. Here, we examined whether increased reappraisal use confers resilience against stress-induced negativity bias. In Study 1, healthy participants (n=43) rated the valence of emotionally ambiguous (surprised) faces before and after an acute stress or control manipulation and reported reappraisal habits. Increased negativity ratings were milder for stressed individuals that reported more habitual reappraisal use. In Study 2 (n=97), we extended this investigation to real-world perceived stress before and during the COVID-19 pandemic. We found that reappraisal tendency moderates the relationship between perceived stress and increased negativity bias. Collectively, these findings suggest that the propensity to reappraise attenuates stress-induced negativity bias when evaluating others under uncertainty.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://psyarxiv.com/hb6c7/" target="_blank">Propensity to reappraise promotes resilience to stress-induced negativity bias</a>
 </div></li>
 <li><strong>Sufficient niacin supply: the missing puzzle piece to COVID-19, and beyond?</strong> -
 <div>
 Definitive antiviral properties are evidenced for niacin, i.e., nicotinic acid (NA), as coronavirus disease 2019 (COVID-19) therapy for both disease recovery and prevention, to the level that reversal or progression of its pathology follows as an intrinsic function of NA supply. This detailed investigation provides a thorough disentanglement of how the downstream inflammatory propagation of ensuing severe acute respiratory virus 2 (SARS-CoV-2) infection is entirely prohibited or reversed upstream out the body to expeditiously restore health with well-tolerated dynamic supplementation of sufficient NA (i.e., ~1-3 grams per day). Culmination of this research leads to realization of the potentially ubiquitous therapeutic and preventive powers of NA against inflammatory disease, in general.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://osf.io/uec3r/" target="_blank">Sufficient niacin supply: the missing puzzle piece to COVID-19, and beyond?</a>
 </div></li>
 <li><strong>The COVID-19 Pandemic’s Impact on OCD Symptoms Varies Widely</strong> -
 <div>
 We conducted a survey of adults with OCD during COVID-19, but found a much higher rate of OCD symptom worsening than similar studies did. Here, we describe our study and discuss potential reasons for these differing patterns of results.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://psyarxiv.com/h8wyt/" target="_blank">The COVID-19 Pandemic’s Impact on OCD Symptoms Varies Widely</a>
 </div></li>
 <li><strong>Losartan promotes cell survival following SARS-CoV-2 infection in vitro</strong> -
 <div>
 Warning: This manuscript presents an in vitro study pending validation by clinical trials. Introduction: Coronavirus disease 2019 (COVID-19) can be associated with mortality and high morbidity worldwide. There is an extensive effort to control infection and disease caused by SARS-CoV-2. This study addressed the hypothesis that angiotensin II type I receptor blocker, Losartan, may restrict pathogenesis caused by SARS-CoV-2 by decreasing viral-induced cytopathological changes by blocking angiotensin II type 1 receptor (AT1R), thus reducing the affinity of the virus for ACE2, and inhibiting papain-like protease of the virus. Method: Losartan inhibitory effect on deubiquitination and deISGylation properties of papain-like protease was investigated using a fluorescence method and gel shift analysis determining its inhibitory effects. The inhibitory effect of Losartan on SARS-CoV-2 cell replication was investigated both when losartan was added to the cell culture 1 hour before (pre-infection group) and 1 hour after (post-infection group) SARS-CoV-2 infection of Vero E6 cells. Results: Losartan treatment of Vero E6 cells prior to and after SARS-CoV-2 infection reduced SARS-CoV-2 replication by 80% and 70% respectively. Losartan was not a strong deubiquitinase and deISGylase inhibitor of PLpro. Conclusion: Losartan added pre- and post-infection to the Vero E6 cell culture significantly prevents cell destruction and replication by SARS-CoV2. Losartan has low side-effects, is readily available, and can be produced at high levels globally, all features of a promising drug in treatment of COVID-19 if validated by clinical trials.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.27.424507v1" target="_blank">Losartan promotes cell survival following SARS-CoV-2 infection in vitro</a>
 </div></li>
 <li><strong>SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters</strong> -
 <div>
 Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure presented with distinct disease manifestations. Intranasal and aerosol inoculation caused more severe respiratory pathology, higher virus loads and increased weight loss. Fomite exposure led to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding was not linked to disease severity, the onset of shedding was. Early shedding was linked to an increase in disease severity. Airborne transmission was more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized of SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.28.424565v1" target="_blank">SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters</a>
 </div></li>
 <li><strong>SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma</strong> -
 <div>
 To investigate the evolution of SARS-CoV-2 in the immune population, we co-incubated authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for 7 passages, but after 45 days, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed at day 80 by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization. Computational modeling predicts that the deletion and insertion in loops N3 and N5 prevent binding of neutralizing antibodies. The recent emergence in the United Kingdom and South Africa of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.28.424451v1" target="_blank">SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma</a>
 </div></li>
 <li><strong>Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection</strong> -
 <div>
 SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism of action in vivo is incompletely understood. Here, we define correlates of protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected animals. Whereas Fc effector functions are dispensable when representative neutralizing mAbs are administered as prophylaxis, they are required for optimal protection as therapy. When given after infection, intact mAbs reduce SARS-CoV-2 burden and lung disease in mice and hamsters better than loss-of-function Fc variant mAbs. Fc engagement of neutralizing antibodies mitigates inflammation and improves respiratory mechanics, and transcriptional profiling suggests these phenotypes are associated with diminished innate immune signaling and preserved tissue repair. Immune cell depletions establish that neutralizing mAbs require monocytes for therapeutic efficacy. Thus, potently neutralizing mAbs require Fc effector functions for maximal therapeutic benefit during therapy to modulate protective immune responses and mitigate lung disease.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.28.424554v1" target="_blank">Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection</a>
 </div></li>
 <li><strong>Emerging SARS-CoV-2 diversity revealed by rapid whole genome sequence typing.</strong> -
 <div>
 Background: Discrete classification of SARS-CoV-2 viral genotypes can identify emerging strains and detect geographic spread, viral diversity, and transmission events. Methods: We developed a tool (GNUVID) that integrates whole genome multilocus sequence typing and a supervised machine learning random forest-based classifier. We used GNUVID to assign sequence type (ST) profiles to each of 69,686 SARS-CoV-2 complete, high-quality genomes available from GISAID as of October 20th 2020. STs were then clustered into clonal complexes (CCs), and then used to train a machine learning classifier. We used this tool to detect potential introduction and exportation events, and to estimate effective viral diversity across locations and over time in 16 US states. Results: GNUVID is a scalable tool for viral genotype classification (available at https://github.com/ahmedmagds/GNUVID) that can be used to quickly process tens of thousands of genomes. Our genotyping ST/CC analysis uncovered dynamic local changes in ST/CC prevalence and diversity with multiple replacement events in different states. We detected an average of 20.6 putative introductions and 7.5 exportations for each state. Effective viral diversity dropped in all states as shelter-in-place travel-restrictions went into effect and increased as restrictions were lifted. Interestingly, our analysis showed correlation between effective diversity and the date that state-wide mask mandates were imposed. Conclusions: Our classification tool uncovered multiple introduction and exportation events, as well as waves of expansion and replacement of SARS-CoV-2 genotypes in different states. Combined with future genomic sampling the GNUVID system could be used to track circulating viral diversity and identify emerging clones and hotspots.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.28.424582v1" target="_blank">Emerging SARS-CoV-2 diversity revealed by rapid whole genome sequence typing.</a>
 </div></li>
 <li><strong>MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans</strong> -
 <div>
 SARS-CoV-2 antibodies develop within two weeks of infection, but wane relatively rapidly post-infection, raising concerns about whether antibody responses will provide protection upon re-exposure. Here we revisit T-B cooperation as a prerequisite for effective and durable neutralizing antibody responses centered on a mutationally constrained RBM B cell epitope. T-B cooperation requires co-processing of B and T cell epitopes by the same B cell and is subject to MHC-II restriction. We evaluated MHC-II constraints relevant to the neutralizing antibody response to a mutationally-constrained B cell epitope in the receptor binding motif (RBM) of the spike protein. Examining common MHC-II alleles, we found that peptides surrounding this key B cell epitope are predicted to bind poorly, suggesting a lack MHC-II support in T-B cooperation, impacting generation of high-potency neutralizing antibodies in the general population. Additionally, we found that multiple microbial peptides had potential for RBM cross-reactivity, supporting previous exposures as a possible source of T cell memory.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.26.424449v1" target="_blank">MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans</a>
 </div></li>
 <li><strong>Prevalence of bacterial pathogens and potential role in COVID-19 severity in patients admitted to intensive care units in Brazil</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Secondary bacterial and fungal infections are associated with respiratory viral infections and invasive mechanical ventilation. In Coronavirus disease 2019 (COVID-19), lung injury by SARS-CoV-2 and impaired immune response can provide a favorable environment for microorganism growth and colonization in hospitalized individuals. Recent studies suggest that secondary bacterial pneumonia is a risk factor associated with COVID-19. In Brazil, knowledge about microbiota present in COVID-19 patients is incipient. This work describes the microbiota of 21 COVID-19 patients admitted to intensive care units from two Brazilian centers. We identified respiratory, nosocomial and bacterial pathogens as prevalent microorganisms. Other bacterial opportunistic and commensal species are also represented. Virulence factors of these pathogenic species, metabolic pathways used to evade and modulate immunological processes and the interconnection between bacterial presence and virulence in COVID-19 progression are discussed.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.22.20248501v2" target="_blank">Prevalence of bacterial pathogens and potential role in COVID-19 severity in patients admitted to intensive care units in Brazil</a>
 </div></li>
 <li><strong>Exploring drugs and vaccines associated with altered risks and severity of COVID-19: a UK Biobank cohort study of all ATC level-4 drug categories</strong> -
 <div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Background: COVID-19 is a major public health concern, yet its risk factors are not well-understood and effective therapies are lacking. It remains unclear how different drugs may increase or decrease the risks of infection and severity of disease. Methods: We studied associations of prior use of all level-4 ATC drug categories (including vaccines) with COVID-19 diagnosis and outcome, based on a prospective cohort of UK Biobank (UKBB). Drug history was based on general practitioner(GP) records. Effects of prescribed medications/vaccinations on the risk of infection, severity of disease and mortality were investigated separately. Hospitalized and fatal cases were categorized as severe infection. We also considered different study designs and conducted analyses within infected patients, tested subjects and the whole population respectively, and for 5 different time-windows of prescriptions. Missing data were accounted for by multiple imputation and inverse probability weighting was employed to reduce testing bias. Multivariable logistic regression was conducted which controls for main confounders. Results: We placed a greater focus on protective associations here, as (residual) confounding by indication and comorbidities tends to bias towards harmful effects. Across all categories, statins showed the strongest and most consistent protective associations. Significant protective effects against severe infection were seen among infected subjects (OR for prescriptions within a 12-month window, same below: 0.50, 95% CI:0.42-0.60), tested subjects (OR=0.63, 0.54-0.73) or in the general population (OR=0.49, 0.42-0.57). A number of top-listed drugs with protective effects were also cardiovascular medications, such as angiotensin converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blocker and beta-blockers. Some other drugs showing protective associations included biguanides (metformin), estrogens, thyroid hormones and proton pump inhibitors, among others. Interestingly, we also observed protective associations by numerous vaccines. The most consistent association was observed for influenza vaccines, which showed reduced odds of infection (OR= 0.73 for vaccination in past year, CI 0.65-0.83) when compared cases to general population controls or test-negative controls (OR=0.60, 0.53-0.68). Protective associations were also observed when severe or fatal infection was considered as the outcome. Pneumococcal, tetanus, typhoid and combined bacterial and viral vaccines (ATC code J07CA) were also associated with lower odds of infection/severity. Further subgroup and interaction analyses revealed difference in protective effects in different clinical subgroups. For example, protective effects of flu and pneumococcal vaccines were weaker in obese individuals, while we observed stronger protective effects of statins in those with cardiometabolic disorders, such as diabetes, coronary artery disease, hypertension and obesity. Conclusions: A number of drugs, including many for cardiometabolic disorders, may be associated with lower odds of infection/severity of infection. Several existing vaccines, especially flu vaccines, may be beneficial against COVID-19 as well. However, causal relationship cannot be established due to risk of confounding. While further studies are required to validate the findings, this work provides a useful reference for future meta-analyses, clinical trials or experimental studies.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.05.20244426v2" target="_blank">Exploring drugs and vaccines associated with altered risks and severity of COVID-19: a UK Biobank cohort study of all ATC level-4 drug categories</a>
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 <li><strong>Are the SIR and SEIR models suitable to estimate the basic reproduction number for the CoViD-19 epidemic?</strong> -
 <div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) becomes pandemic but presents different incidences in the world. Mathematical models were formulated to describe the coronavirus disease 2019 (CoViD-19) epidemic in each country or region. At the beginning of the pandemic, many authors used the SIR (susceptible, infectious, and recovered compartments) and SEIR (including exposed compartment) models to estimate the basic reproduction number R0 for the CoViD-19 epidemic. These simple deterministic models assumed that the only available collection of the severe CoViD-19 cases transmitted the SARS-CoV-2 and estimated lower values for R0, ranging from 1.5 to 3.0. However, the major flaw in the estimation of R0 provided by the SIR and SEIR models was that the severe CoViD-19 patients were hospitalized, and, consequently, not transmitting. Hence, we proposed a more elaborate model considering the natural history of CoViD-19: the inclusion of asymptomatic, pre-symptomatic, mild and severe CoViD-19 compartments. The model also encompassed the fatality rate depending on age. This SEAPMDR model estimated R0 using the severe CoViD-19 data from São Paulo State (Brazil) and Spain, yielding higher values for R0, that is, 6.54 and 5.88, respectively. It is worth stressing that this model assumed that severe CoViD-19 cases were not participating in the SARS-CoV-2 transmission chain. Therefore, the SIR and SEIR models are not suitable to estimate R0 at the beginning of the epidemic by considering the isolated severe CoViD-19 data as transmitters.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.10.11.20210831v3" target="_blank">Are the SIR and SEIR models suitable to estimate the basic reproduction number for the CoViD-19 epidemic?</a>
 </div></li>
 <li><strong>The effect of a national lockdown in response to COVID-19 pandemic on the prevalence of clinical symptoms in the population</strong> -
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 The vast and rapid spread of COVID-19 calls for immediate action from policy-makers, and indeed various lockdown measures were implemented in many countries. Here, we utilized nationwide surveys that assess COVID-19 associated symptoms to analyze the effect of the lockdown policy in Israel on the prevalence of clinical symptoms in the population. Daily symptom surveys were distributed online and included fever, respiratory symptoms, gastrointestinal symptoms, anosmia and Ageusia. A total of 1,456,461 survey responses were analyzed. We defined a single measure of symptoms, Symptoms Average (SA), as the mean number of symptoms reported by responders. Data were collected between March 15th to May 11th, 2020. Notably, following severe lockdown measures, we found that between March 15th and April 20th, SA sharply declined by 83.8%, as did every individual symptom, including the most common symptoms reported by our responders, cough and rhinorrhea andnasal congestion, which decreased by 74.1% and 69.6%, respectively. Individual symptoms exhibit differences in reduction dynamics, suggesting differences in the medical conditions that they represent or in the nature of the symptoms themselves. The reduction in symptoms was observed in all the cities in Israel, and in several stratifications of demographic characteristics. Between April 20th and May 11th, following several subsequent lockdown relief measures, the decrease in SA and individual symptoms halted and they remain relatively stable with no significant change. Overall, these results demonstrate a profound decrease in a variety of clinical symptoms following the implementation of a lockdown in Israel. As our survey symptoms are not specific to COVID-19 infection, this effect likely represents an overall nationwide reduction in the prevalence of infectious diseases, including COVID-19. This quantification may be of major interest for COVID-19 pandemic, as many countries consider implementation of lockdown strategies.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.04.27.20076000v4" target="_blank">The effect of a national lockdown in response to COVID-19 pandemic on the prevalence of clinical symptoms in the population</a>
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 <li><strong>Modeling the flow of the COVID-19 in Germany: The efficacy of lockdowns and social behavior</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 This study develops a computer simulation in understanding the flow of the COVID-19 in Germany between January 2020 and July 2020. This aims to analyze not only the flow of the COVID-19 but also the efficacy of taken measures during the given period. The computer model is based on the SEIR concept and it is based on the system dynamics approach in which some uncertain parameters are estimated through the calibration process. Moreover, the SEIR computer model is developed by considering different flows of COVID-19 cases in older and young people in Germany. This study successfully reproduces similar patterns of infected, recovered, and death cases. Moreover, as the SEIR model can successfully reproduce similar patterns, the SEIR model can be a basis to estimate other resources such as health workers and bed capacities.
 </p>
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 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.21.20248605v2" target="_blank">Modeling the flow of the COVID-19 in Germany: The efficacy of lockdowns and social behavior</a>
 </div></li>
 </ul>
 <h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the Efficacy of High Doses of Methylprednisolone in SARS-CoV2 ( COVID-19) Pneumonia Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Methylprednisolone, Placebo<br/><b>Sponsor</b>:   Azienda Unità Sanitaria Locale Reggio Emilia<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dendritic Cell Vaccine to Prevent COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: AV-COVID-19<br/><b>Sponsors</b>:   Indonesia-MoH;   Aivita Biomedical, Inc.;   PT AIVITA Biomedika Indonesia;   National Institute of Health Research and Development, Ministry of Health Republic of Indonesia;   RSUP Dr. Kariadi Semarang, indonesia;   Faculty of Medicine University of Diponegoro, Indonesia<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Ivermectin;   Drug: Hydroxychloroquine;   Behavioral: personal protective Measures<br/><b>Sponsor</b>:   Benha University<br/><b>Completed</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Dalcetrapib in Patients With Confirmed Mild to Moderate COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Dalcetrapib;   Other: Placebo<br/><b>Sponsors</b>:   DalCor Pharmaceuticals;   The Montreal Health Innovations Coordinating Center (MHICC);   Covance<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase 3 Inhaled Novaferon Study in Hospitalized Patients With Moderate to Severe COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Novaferon;   Biological: Placebo<br/><b>Sponsor</b>:   Genova Inc.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Anakinra;   Drug: Placebo<br/><b>Sponsor</b>:   Hellenic Institute for the Study of Sepsis<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (SARS-CoV-2 Infected)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: AZVUDINE;   Drug: AZVUDINE placebo<br/><b>Sponsors</b>:   HRH Holdngs Limited;   GALZU INSTITUTE OF RESEARCH, TEACHING, SCIENCE AND APPLIED TECHNOLOGY, Brazil;   SANTA CASA DE MISERICORDIA DE CAMPOS HOSPITAL (SCMCH), Brazil;   UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE (UENF), Brazil<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhaled Ivermectin and COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ivermectin Powder<br/><b>Sponsor</b>:   Mansoura University<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating the Impact of EnteraGam In People With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: Bovine Plasma-Derived Immunoglobulin Concentrate;   Other: Standard of care<br/><b>Sponsors</b>:   Entera Health, Inc;   Lemus Buhils, SL;   Clinical Research Unit, IMIM (Hospital del Mar Medical Research Institute)<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Remdesivir and Tociluzumab for the Management of Severe COVID-19: A Randomized Controlled Trial</strong> - <b>Conditions</b>:   Covid19;   Covid-19 ARDS<br/><b>Interventions</b>:   Drug: Remdesivir;   Drug: Tocilizumab<br/><b>Sponsors</b>:   M Abdur Rahim Medical College and Hospital;   First affiliated Hospital of Xi'an Jiaoting University<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AZD1222 Vaccine in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AZD1222;   Biological: rAd26-S<br/><b>Sponsors</b>:   AstraZeneca;   R-Pharm<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AZD1222;   Biological: rAd26-S<br/><b>Sponsors</b>:   R-Pharm;   AstraZeneca<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Investigate the Treatment Effect of Colchicine in Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Colchicine;   Drug: Standard COVID-19 care<br/><b>Sponsors</b>:   Ayub Teaching Hospital;   Universidad de Murcia<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of Prognostic Modification in COVID-19 Patients in Early Intervention Treatment</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Azithromycin / Ivermectin / Ribaroxaban / Paracetamol;   Drug: Azithromycin / Ribaroxaban / Paracetamol<br/><b>Sponsors</b>:   Gilberto Cruz Arteaga;   Coordinación de Investigación en Salud, Mexico<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of hzVSF-v13 in Patients With COVID-19 Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: hzVSF-v13;   Drug: Placebo (Normal saline solution)<br/><b>Sponsor</b>:   ImmuneMed, Inc.<br/><b>Recruiting</b></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling</strong> - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected more than 10 million individuals. A typical feature of COVID-19 is the suppression of type I and III interferon (IFN)-mediated antiviral immunity. However, the molecular mechanism by which SARS-CoV-2 evades antiviral immunity remains elusive. Here, we reported that the SARS-CoV-2 membrane (M) protein inhibits the production of type I and III...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The potential mechanism of N-acetylcysteine in treating COVID-19</strong> - N-Acetylcysteine (NAC) has been proposed and used to treat coronavirus disease 2019 (COVID-19). By reviewing the existing pathological studies of COVID-19, it was found that abundant mucus secretion, formation of a hyaline membrane (supportive of acute respiratory distress syndrome), and interstitial fibrous exudation may be important characteristics of COVID-19 and may be pathological targets of drug therapy. In addition, multiple extrapulmonary organ injuries in COVID-19 may be associated with...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The fight against human viruses: how NMR can help</strong> - CONCLUSION: Considering the NMR-based work conducted on different viruses, we believe that in the close future much more NMR efforts will be devoted to discover novel anti SARS-CoV-2 agents.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions</strong> - Remdesivir was recently approved to treat COVID-19. While this antiviral agent delivers clinical benefits, several safety concerns in many cases have been raised. This study reports that remdesivir at nanomolar concentrations inhibits carboxylesterase-2 (CES2) through covalent modifications. CES2 is a major drug-metabolizing enzyme. The combination of high potency with irreversible inhibition concludes that cautions must be exercised when remdesivir is used along with drugs hydrolyzed by CES2.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Might proton pump or sodium-hydrogen exchanger inhibitors be of value to ameliorate SARs-CoV-2 pathophysiology?</strong> - Discovering therapeutics for COVID-19 is a priority. Besides high-throughput screening of compounds, candidates might be identified based on their known mechanisms of action and current understanding of the SARs-CoV-2 life cycle. Using this approach, proton pump (PPIs) and sodium-hydrogen exchanger inhibitors (NHEIs) emerged, because of their potential to inhibit the release of extracellular vesicles (EVs; exosomes and/or microvesicles) that could promote disease progression, and to directly...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS-CoV-2 in the respiratory tract</strong> - As the death toll of Coronavirus disease 19 (COVID-19) continues to rise worldwide, it is imperative to explore novel molecular mechanisms for targeting SARS-CoV-2. Rather than looking for drugs that directly interact with key viral proteins inhibiting its replication, an alternative and possibly add-on approach is to dismantle the host cell machinery that enables the virus to infect the host cell and spread from one cell to another. Excellent examples of such machinery are host cell proteases...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Spatial and temporal roles of SARS-CoV PL(pro) -A snapshot</strong> - SARS-CoV and SARS-CoV-2 encode four structural and accessory proteins (spike, envelope, membrane and nucleocapsid proteins) and two polyproteins (pp1a and pp1ab). The polyproteins are further cleaved by 3C-like cysteine protease (3CL^(pro) ) and papain-like protease (PL^(pro) ) into 16 nonstructural proteins (nsps). PL^(pro) is released from nsp3 through autocleavage, and then it cleaves the sites between nsp1/2, between nsp2/3 and between nsp3/4 with recognition motif of LXGG, and the sites in...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin</strong> - The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means of adherence and invasion. Heparin, a widely used anticoagulant drug, is structurally similar to HS and is a common experimental proxy. Exogenous heparin prevents infection by a range of viruses, including S-associated coronavirus isolate HSR1. Here,...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Therapeutic Approach Against 2019-nCoV by Inhibition of the ACE-2 receptor</strong> - The continued spread of the 2019 novel coronavirus (2019-nCoV) has prompted global concern. The formal name given to 2019-nCoV by the World Health Organization is COVID-19, while the International Committee on Taxonomy has named it severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Due to this viral attack, nations around the world have issued lockdown restrictions. Presently, there is no effective way to control the spread of 2019-nCoV, except through social distancing and hygienic...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic</strong> - Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in Coronavirus Disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrate that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs</strong> - For the initial phase of pandemic of coronavirus disease 2019 (COVID-19), repurposing drugs that in vitro inhibit severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been attempted with overlooked or overestimated efficacy owing to limited clinical evidence. Most early clinical trials have the defects of study design, small sample size, non-randomized design, or different timings of treatment initiation. However, well-designed studies on asymptomatic or mild, or pediatric cases of...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro Enzymatic Activity Assay</strong> - COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 virus with important political, socio-economic, and public health consequences. Inhibiting replication represents an important antiviral approach, and in this context two viral proteases, the SARS-CoV-2 main and papain-like proteases (PL^(pro)), which cleave pp1a and pp1ab polypeptides, are critical. Along with protease activity, the PL^(pro) possesses deubiquitinating activity, which is important in immune regulation. Naphthalene-based...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics</strong> - The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common immunopathological event in SARS-CoV-2, SARS-CoV, and MERS-CoV infections. Fast lung deterioration results of cytokine storm determined by a robust immunological response leading to ARDS and multiple organ failure. Here, we show cysteine protease Cathepsin L (CatL) involvement with severe acute respiratory syndrome coronavirus...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational and Network Pharmacology Analysis of Bioflavonoids as Possible Natural Antiviral Compounds in Covid-19</strong> - Bioflavonoids are the largest group of plant-derived polyphenolic compounds with diverse biological potential and have also been proven efficacious in the treatment of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The present investigation validates molecular docking, simulation, and MM-PBSA studies of fifteen bioactive bioflavonoids derived from plants as a plausible potential antiviral in the treatment of COVID-19. Molecular docking studies for 15...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Potential Peptide From Soy Cheese Produced Using Lactobacillus delbrueckii WS4 for Effective Inhibition of SARS-CoV-2 Main Protease and S1 Glycoprotein</strong> - The COVID-19 pandemic caused by novel SARS-CoV-2 has resulted in an unprecedented loss of lives and economy around the world. In this study, search for potential inhibitors against two of the best characterized SARS-CoV-2 drug targets: S1 glycoprotein receptor-binding domain (RBD) and main protease (3CL^(Pro)), was carried out using the soy cheese peptides. A total of 1,420 peptides identified from the cheese peptidome produced using Lactobacillus delbrueckii WS4 were screened for antiviral...</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid 19 - Chewing Gum</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313269181">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313300659">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19</strong> - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN313339294">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251184">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251182">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN312324209">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물</strong> - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR313434044">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU311608060">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 RBD共轭纳米颗粒疫苗</strong> - 本发明涉及免疫医学领域，具体而言，涉及一种SARS‑CoV‑2 RBD共轭纳米颗粒疫苗。该疫苗包含免疫原性复合物，所述免疫原性复合物包含：a）与SpyCatcher融合表达的载体蛋白自组装得到的纳米颗粒载体；b）与SpyTag融合表达的SARS‑CoV‑2病毒的RBD抗原；所述载体蛋白选自Ferritin、mi3和I53‑50；所述载体蛋白与所述抗原之间通过SpyCatcher‑SpyTag共价连接。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN313355625">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Устройство электронного контроля и дистанционного управления аппарата искусственной вентиляции легких</strong> - Полезная модель относится к медицинской технике, а именно к устройствам для воздействия на дыхательную систему пациента смесью различных газов, в частности, к устройствам для проведения искусственной вентиляции легких (ИВЛ). Технический результат предлагаемой полезной модели заключается в решении технической проблемы, состоящей в необходимости расширения арсенала технических средств, предназначенных для электронного контроля и управления ИВЛ, путем реализации возможности дистанционного управления аппаратами ИВЛ в медицинских учреждениях, не оборудованных кабельными вычислительными сетями. Указанный технический результат достигается благодаря тому, что в известное устройство электронного контроля и дистанционного управления аппарата ИВЛ, содержащее центральный микроконтроллер, а также программно-аппаратные средства управления функциями доставки воздушной смеси пациенту и многоуровневой тревожной сигнализации об отклонениях от нормативных условий и технических неполадках в аппарате ИВЛ, введены связанные друг с другом микроконтроллер связи и дистанционного управления и радиомодем, выполненный с возможностью связи с точками доступа радиканальной сети, при этом центральный микроконтроллер устройства выполнен с дополнительными входом/выходом, которые связаны с управляющими выходом/входом микроконтроллера связи и дистанционного управления, а, в зависимости от типа применяемой в медицинском учреждении радиоканальной сети связи и передачи данных, радиомодем может быть выполнен в виде интерфейсного аудиомодуля Bluetooth 4.0 BLE, приемопередающего модуля Wi-Fi либо устройства "малого радиуса действия", работающего по технологии LoRa на нелицензируемых частотах мегагерцового диапазона, например, в диапазоне 868 МГц. 3 з.п. ф-лы, 1 ил. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=RU313244211">link</a></p></li>
 </ul>
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 <h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-new-yorker">From New Yorker</a></li>
 <li><a href="#from-vox">From Vox</a></li>
 <li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
 <li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
 <li><a href="#from-bbc-europe">From BBC: Europe</a></li>
 <li><a href="#from-ars-technica">From Ars Technica</a></li>
 <li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Plague Year</strong> - The mistakes and the struggles behind America’s coronavirus tragedy. - <a href="https://www.newyorker.com/magazine/2021/01/04/the-plague-year">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Deep Origins of Latino Support for Trump</strong> - The leaders of the Hispanic Republican movement today haven’t felt such momentum for twenty years. - <a href="https://www.newyorker.com/news/the-political-scene/the-deep-origins-of-latino-support-for-trump">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can Wall Street’s Heaviest Hitter Step Up to the Plate on Climate Change?</strong> - More significant than BlackRock executives’s pledges is the firm’s continued inclusion of fossil-fuel companies in its index funds. - <a href="https://www.newyorker.com/news/annals-of-a-warming-planet/can-wall-streets-heaviest-hitter-step-up-to-the-plate-on-climate-change">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump Directs His Wrecking Ball at the COVID-19 Relief Bill and Mitch McConnell</strong> - After a week spent largely out of the public eye, the President reappeared with a flurry of pardons and an attack on the House Speaker’s coronavirus relief bill. - <a href="https://www.newyorker.com/news/our-columnists/trump-directs-his-wrecking-ball-at-the-covid-19-relief-bill-and-mitch-mcconnell">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Georgia Trump Fans Say the Last Election Was a Sham. Will They Vote in This One?</strong> - Kelly Loeffler and David Perdue are trying to placate the President and run for the Senate at the same time. - <a href="https://www.newyorker.com/news/us-journal/georgia-trump-fans-say-the-2020-election-was-a-sham-will-they-vote-in-this-one">link</a></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-vox">From Vox</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The House just voted to override Trump’s veto of a $740 billion defense bill</strong> -
 <figure>
 <img alt="" src="https://cdn.vox-cdn.com/thumbor/DR65RQFD849ZkEXUiqoqPnBlSzA=/883x0:7978x5321/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68590824/1290579853.0.jpg"/>
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 Army soldiers retrieve their duffel bags at Fort Drum, New York, after they returned home in December from a nine-month deployment to Afghanistan. | John Moore/Getty Images
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The National Defense Authorization Act had passed both chambers of Congress with veto-proof majorities.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E2xx1c">
 The House voted on Monday to override President Donald Trump’s veto of a sweeping $740 billion defense bill that previously passed in both chambers of Congress with veto-proof majorities.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W2XD5f">
 Though some Republicans sided with the president, the 322-87 vote marked a rare bipartisan rebuke of Trump’s agenda during his final days in office. The House needed 288 votes to override the veto. The Senate is expected to vote on the bill on Tuesday, where a two-thirds majority will also need to support overriding the veto in order to secure pay increases for troops and ensure that training regimens can continue.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IZPUcl">
 Trump had vetoed the bill, which is known as the National Defense Authorization Act (NDAA), on the basis that it did not repeal Section 230, a law that shields private internet companies from liability for what users post on their websites and allows them to take down or restrict content at their discretion. In a public message to Congress last week, he <a href="https://www.whitehouse.gov/briefings-statements/presidential-veto-message-house-representatives-h-r-6395/">said</a> that the law “facilitates the spread of foreign disinformation online, which is a serious threat to our national security and election integrity.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2jk1ef">
 But Trump’s targeting of Section 230 appears to be personal in nature: He has recently sparred with Twitter about its decision to place warnings on and restrict engagement with his <a href="https://www.theverge.com/2020/11/6/21552471/trump-twitter-restricted-false-election-claims-moderation">false tweets about widespread election fraud</a>. The company has also suggested that Trump could get <a href="https://techcrunch.com/2020/11/18/trump-will-lose-protected-twitter-status-after-his-presidency/">banned</a> from the platform once he is no longer in office.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6T0dq1">
 Trump also took issue with provisions in the bill that require the military to rename facilities named after figures in Confederate history, limit the amount of defense funds that could be used to construct his US-Mexico border wall, and impose additional oversight on the withdrawal of troops from Afghanistan, Germany, and South Korea.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vKsjtY">
 “Unfortunately,” Trump wrote, “the Act fails to include critical national security measures, includes provisions that fail to respect our veterans and our military’s history, and contradicts efforts by my Administration to put America first in our national security and foreign policy actions. It is a ‘gift’ to China and Russia.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="j2RPdN">
 The NDAA, which sets the defense priorities for the nation and distributes resources to US troops, has been passed every year for 59 years without fail. The House had previously passed the bill <a href="https://www.cnn.com/2020/12/08/politics/defense-bill-house-vote-trump-veto-threat/index.html">335-78</a> and the Senate had passed it <a href="https://www.cnn.com/2020/12/11/politics/senate-defense-bill-trump-veto-proof-majority/index.html">84-13</a>, both over the two-thirds threshold needed to override a veto.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sPUBfV">
 Trump’s veto of the bill — one of nine over the course of his presidency — pitted members of his own party against each other. Before Monday, Congress had not successfully overridden any of his vetoes.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jCVB41">
 House Minority Leader Kevin McCarthy, who previously voted for the bill, and members of the conservative House Freedom Caucus had <a href="https://www.foxnews.com/politics/house-freedom-caucus-presidents-ndaa-veto-threat-military">announced</a> their intentions to reject the veto override ahead of Monday’s vote. But others, including Rep. Mac Thornberry, the top Republican on the House Armed Services Committee, signaled that they would override the veto. Though he did not mention Trump directly, Thornberry told his GOP colleagues in a note <a href="https://www.politico.com/news/2020/12/24/republicans-armed-services-ndaa-veto-450387">obtained by Politico</a> that they should ignore “distortions or misrepresentations” of the bill, and distributed fact sheets about the provisions of the bill with which the president took issue.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fg7Ubc">
 “Your decision should be based upon the oath we all took, which was to the Constitution rather than any person or organization,” he reportedly said.
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 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Netflix’s Death to 2020 rehashes jokes we all spent the last 12 months making</strong> -
 <figure>
 <img alt="" src="https://cdn.vox-cdn.com/thumbor/1hQg7aG-FL1aoY09fw9_RxFs3RU=/200x0:3400x2400/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68590700/DEATH_Unit_00892R.0.jpg"/>
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 Tracey Ullman as Queen Elizabeth II in Death to 2020. | Keith Bernstein/Netflix
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Death to 2020’s most urgent 2020 commentary is that social media is ruining everything. Wow.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LJhI6G">
 In the opening moments of Netflix’s new comedy special <em>Death to 2020</em>, Samuel L. Jackson, playing a jaded veteran reporter named Dash Bracket, asks the fictional filmmakers what their fictional documentary is for.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SV3UMB">
 The offscreen interviewers never answer the question, and that lack of clarity sums up this hour-long parody. A mockumentary “year in review” from Charlie Brooker, a.k.a. the <a href="https://www.vox.com/black-mirror"><em>Black Mirror</em></a> guy, <em>Death to 2020</em> is an experiment that never justifies itself.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oJS4N1">
 Star-studded and full of rote archival footage, <em>Death to 2020</em> is aggressively bland, as if something about 2020 defied Brooker’s attempts to parody it. It’s not as if he doesn’t make the effort: The skit-filled satire boasts nearly 20 writers. There aren’t 20 jokes to be found in this retrospective, however, and that’s not because the subject isn’t rife with absurdity.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qPRZTn">
 But unlike Brooker’s more shrewd comedic efforts — for example, the acerbic satire of <em>Black Mirror</em>’s Gamergate-inspired season four episode “<a href="https://www.vox.com/culture/2017/12/29/16804664/black-mirror-uss-callister-recap-season-4-review">USS Callister</a>” — this outing is completely toothless. Most of the show’s 67 minutes just tell us what we already know, because we just lived through it. The premise of <em>Death to 2020</em> seems to be that the audience will enjoy reliving the year, much in the way that <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fwww.rifftrax.com%2Fabout&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2F22203327%2Fdeath-to-2020-review-social-media" rel="sponsored nofollow noopener" target="_blank">Rifftrax</a> fans enjoy subjecting themselves to bad movies. But the horrors of 2020 aren’t exactly A-list box office draws or must-watch material — and without quality commentary to enliven the trip down memory lane, the film is a tedious hour wasted.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SjQKOy">
 From the beginning, <em>Death to 2020 </em>is palpably unfunny. Hugh Grant dons a blond wig and plays a historian who snarks about politicians. Tracey Ullman dons a blonde wig and plays the queen, who snarks about Meghan Markle. There’s an Elon Musk parody named Bark Multiverse (<a href="https://www.imdb.com/name/nm3529685/?ref_=tt_cl_t4">Kumail Nanjiani</a>), who builds a survival bunker, because of course there is and of course he does. A scientist named Pyrex Flask (<a href="https://www.imdb.com/name/nm4478685/?ref_=tt_cl_t6">Samson Kayo</a>) drops the mildest humor imaginable about Covid-19 and the pandemic.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Yfl07y">
 It’s all incredibly banal and deeply uninspired. The most stringent thing the documentary has to say about Republicans who support Trump is — wait for it — they’re <em>creating their own reality. </em>The most stringent thing it can find to fling at Joe Biden is — wait for it — he’s <em>really old</em>. I bet you can already guess exactly what the writers think of <a href="https://www.vox.com/culture/2019/12/30/20879720/what-is-cancel-culture-explained-history-debate">cancel culture</a>. That’s right: They’re not fans!
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J9BRPd">
 This type of paint-by-numbers humor doesn’t really lend itself to tackling deeper aspects of the culture war, such as the ongoing <a href="https://www.vox.com/policy-and-politics/2017/11/2/16588964/america-epistemic-crisis">epistemic crisis</a> or the protests against <a href="https://www.vox.com/police-violence">police brutality</a>, but Brooker and company have, of course, given themselves the assignment of raising those issues too. It’s all in the service of painting the coronavirus as a four-in-one apocalyptic horseman, bearing down on us for our sin of spending too much time screaming at one another on Twitter.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6sxo1u">
 <a href="https://www.vox.com/2019/6/5/18648965/black-mirror-smithereens-recap-season-5-review">Brooker does love skewering</a> narcissistic, extremely online types for being too addicted to social media. But if that sermon felt empty when it was dressed up in <em>Black Mirror</em>’s fancier clothing, here, where it’s framed as the mockumentary’s main, threadbare takeaway, it just comes off as vapid and unoriginal. Perhaps <em>Death to 2020</em>’s absolute worst offense is that it wastes <em>Stranger Things</em>’ <a href="https://www.vox.com/culture/2017/10/30/16569330/dad-steve-harrington-stranger-things-2-memes">resident teen dad, Joe Keery</a>, on its dumb social media jokes, tarnishing his hitherto flawless track record. We get it, Charlie Brooker: YouTubers and influencers are all shallow and clout-obsessed, and 2008 wants its punchlines back. Thank u, next.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LIrDSx">
 Brooker achieves something close to meaningful commentary on the year only when he and the rest of the writers stop cracking tired jokes and allow the absurdity of the year’s images to speak for themselves. For example, during a clip from an anti-Covid-19 protest, one would-be patriot holds a sign that proclaims, “The vaccine is in the boxcar” — an apparent reference to the Holocaust. This moment goes unaddressed by the film, because it’s nearly unaddressable. How do you respond to that level of disconnect from reality?
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k88H0p">
 Unfortunately for us, those moments of silent commentary are much too rare. Brooker and his army of writers cover every major beat from the last 14 months — if not exhaustively, then exhaustedly (and exhaustingly). The infamous US presidential debate? “A rap battle in a senior home.” As for Trump, perhaps he’d have been less susceptible to Covid “if someone told him white hoods protect against the virus.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PnFs3C">
 I take it back. The worst offense of <em>Death to 2020</em> isn’t that it wastes so many of its star-studded cast members, from Leslie Jones to Lisa Kudrow. It’s that, for all it wants to paint social media as the enemy, every bit of its humor feels like a social media rehash. It’s as if the humor writers searched Twitter for the algorithmically generated “top” tweets on every one of their assigned topics, scribbled down anything with more than 1,500 likes, and called it a day.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="56WjMR">
 Maybe if you truly weren’t paying any attention to world news, or social media, during the last 12 months, you might get something out of this hit parade. But otherwise, <em>Death to 2020</em> is ultimately just more of the same painfully humorless noise that’s made up most of the year.
 </p>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The House has voted to increase stimulus checks to $2,000</strong> -
 <figure>
 <img alt="Nancy Pelosi at the podium wearing a mask." src="https://cdn.vox-cdn.com/thumbor/gzzi0iee5fr5a_BJFREUvZlcfEg=/304x0:5168x3648/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68590606/1292320951.0.jpg"/>
 <figcaption>
 House Speaker Nancy Pelosi during a press conference on Capitol Hill on December 2020. | Tasos Katopodis/Getty Images
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 It’s probably dead in the Senate.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="afLys0">
 The House of Representatives has voted to increase the latest round of <a href="https://www.vox.com/coronavirus-covid19">Covid-19</a> <a href="https://www.vox.com/22193651/second-stimulus-check-2020-update-when-how-much">stimulus checks</a> from $600 to $2,000. Even though President <a href="https://www.vox.com/donald-trump">Donald Trump</a> supports the move, it is unlikely to get far in the Senate.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E2JApO">
 On Monday, House Speaker Nancy Pelosi held a recorded vote on a standalone bill to increase “economic impact payments” — in other words, stimulus checks — to $2,000. House Democrats attempted a vote by unanimous consent on the matter on Christmas Eve, but <a href="https://www.vox.com/2020/12/24/22197748/stimulus-checks-2000-congress-trump-pelosi-mcconnell">it was blocked by House Republicans</a>. This time, it passed the House by a 275-134 vote.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M3NVLI">
 The <a href="https://www.vox.com/2020/12/21/22193134/covid-19-stimulus-deal-house-senate">$900 billion stimulus package</a> passed by Congress last week and signed into law by President Trump on Sunday has in it stimulus checks for $600 for individuals who made up to $75,000 a year in 2019, or $1,200 for couples who made up to $150,000 as well as an additional $600 per child. Many politicians, activists, and experts have called for that number to be higher — under the CARES Act in the spring, stimulus checks were for $1,200 for individuals.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0TIX4Y">
 Negotiators settled on $600, and the general belief was that Trump agreed with whatever Treasury Secretary Steven Mnuchin, who called the bill “fabulous,” agreed with. But then after Congress passed the bill and went home, Trump <a href="https://twitter.com/realDonaldTrump/status/1341537886315950080?s=20">released a video</a> on Twitter slamming it as a “disgrace” and calling for checks to be bumped up to $2,000.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="z65LB6">
 Democrats were quick to act and tried to use the president’s support for bigger checks as leverage to get Republicans in Congress to budge on the issue — or at the very least highlight that they won’t. Pelosi <a href="https://twitter.com/speakerpelosi/status/1341557535732604935">responded</a> to Trump’s tweet saying that Republicans had “repeatedly refused to say what amount” the president wanted for checks and that “at last” he had agreed to $2,000. “Let’s do it!” she wrote.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="grxc3o">
 Rep. Alexandria Ocasio-Cortez (D-NY) echoed Pelosi’s sentiment, noting that she and Rep. Rashida Tlaib (D-MI) had <a href="https://twitter.com/AOC/status/1341572295769415682">co-written an amendment for $2,000 checks</a>. The House voted on <a href="https://waysandmeans.house.gov/media-center/press-releases/chairman-neal-introduces-cash-act-provide-2000-payments-americans-need">the CASH Act</a> to increase stimulus payments, which was put forth by House Ways and Means Committee Chair Richard Neal (D-MA) on Christmas Eve.
 </p>
 <div id="udrOOn">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 Me and <a href="https://twitter.com/AOC?ref_src=twsrc%5Etfw"><span class="citation">@AOC</span></a> have the amendment ready. Send the bill back, and we will put in the $2,000 we’ve been fighting for that your party has been blocking. <a href="https://t.co/GGXtJt77D9">pic.twitter.com/GGXtJt77D9</a>
 </p>
 — Rashida Tlaib (<span class="citation">@RashidaTlaib</span>) <a href="https://twitter.com/RashidaTlaib/status/1341568309955874818?ref_src=twsrc%5Etfw">December 23, 2020</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rWH2G2">
 After the president signed the stimulus bill on Sunday, Pelosi <a href="https://www.speaker.gov/newsroom/122720">said in a statement</a> that he “must immediately call on Congressional Republicans to end their obstruction and to join him and Democrats in support of our stand-alone legislation to increase direct payment checks to $2,000,” to be brought to the floor on Monday. “Every Republican vote against this bill is a vote to deny the financial hardship that families face and to deny the American people the relief they need,” she said.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dGD4H2">
 Monday’s House vote was conducted under a “<a href="https://about.bgov.com/news/what-to-know-in-washington-trump-yields-and-signs-virus-package/">suspension of rules</a>,” which required a two-thirds majority for it to pass.
 </p>
 <h3 id="7E0jTD">
 Just because Trump is into $2,000 stimulus checks doesn’t mean the rest of his party is
 </h3>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6V6OsO">
 The big question after the vote on $2,000 stimulus checks passed the House on Monday is what happens next. And the answer is probably not much.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xuedHe">
 Many Republicans have never been into the idea of bigger stimulus checks — Sen. Josh Hawley (R-MO) tried to advocate for $1,200 checks alongside Sen. Bernie Sanders (I-VT) and <a href="https://www.axios.com/ron-johnson-hawley-stimulus-checks-e5bff298-9207-407e-bcc2-79caa833c37c.html">was blocked by a member of his own party</a>. As <a href="https://www.vox.com/2020/12/23/22197037/trump-2000-stimulus-checks">Vox’s Li Zhou explained</a>, Republicans have chafed at a bigger relief bill because of concerns about the deficit, and one bipartisan proposal in the lead-up to the final deal didn’t have checks in it at all.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0aA4sD">
 Senate Minority Leader Chuck Schumer <a href="https://twitter.com/SenSchumer/status/1343374127479083008?s=20">said on Twitter</a> that he will move to pass $2,000 checks in the Senate and that no Democrats will object. “Will Senate Republicans?” he asked. The answer is almost surely yes.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eYHdsC">
 When asked by reporters whether $2,000 checks would get 60 votes in the Senate, Sen. Roy Blunt (R-MO) <a href="https://www.nbcnews.com/politics/white-house/pelosi-says-house-vote-bigger-stimulus-payments-after-gop-blocks-n1252335">said they would not</a>. Senate Majority Leader Mitch McConnell has not weighed in on the matter. His office did not respond to a request for comment on how he’s thinking about the issue, but he is unlikely to support it. In a <a href="https://twitter.com/senatemajldr/status/1343365527851429888?s=20">statement</a> commending Trump for signing the $900 billion relief bill on Sunday, he didn’t acknowledge the measure at all.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wuJwE9">
 The president has complicated the matter further by tacking onto his $2,000 ask some unrelated items. In a <a href="https://twitter.com/senatemajldr/status/1343365527851429888?s=20">statement</a> after signing the stimulus package, Trump said he wants the Senate to “start the process” for a vote on increasing checks, <a href="https://www.vox.com/recode/2020/5/28/21273241/section-230-explained-trump-social-media-twitter-facebook">repealing Section 230</a> — an internet speech law — and commencing an investigation into (unfounded) claims of voter fraud. Sen. Lindsey Graham (R-SC) <a href="https://twitter.com/LindseyGrahamSC/status/1343367962007363584?s=20">has been calling for</a> the Senate to increase checks at the same time it scraps Section 230 as well.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eAXeU6">
 One thing does not have to do with the other — getting people much-needed help in a time of crisis and whether Twitter can slap a label onto the president’s false tweets are two different things.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E4u3Yl">
 Despite the House’s vote on Monday, it remains unlikely that $2,000 checks are on the way.
 </p>
 <h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aus vs Ind | Rahane brought calmness in dressing room, says Ashwin</strong> - Adjudged Player of the Match, Rahane led by example by scoring a century.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nekhbet, Mzilikazi, Sanctuary Cove, Shelomi and Crown Of Stars excel</strong> - Nekhbet, Mzilikazi, Sanctuary Cove, Shelomi and Crown Of Stars excelled when the horses were exercised here on Tuesday (Dec. 29).Outer sand: 800m: St</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Former New Zealand batsman John F. Reid dies aged 64</strong> - In a Test career that ran from 1979 to 1986 he scored 1,296 runs at an average of 46</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs India | I have let Ashwin dictate terms, no spinner has done that to me before this: Smith</strong> - The series is currently level at 1-1 after India secured an eight-wicket triumph in the second game here on Tuesday</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gill and Siraj showed character: Ajinkya Rahane</strong> - Rahane said it is never easy for debutants to be consistently disciplined in their game but Gill and Siraj showed how it is done.</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 dry run | ‘Beneficiaries’ undergo dummy vaccination in Gujarat</strong> - According to a WHO official, the dry run was vital and was being conducted as per the training protocol related to actual vaccination.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Duck deaths in Kuttanad: samples to be sent to Bhopal</strong> - Around 22,000 ducks die in Thalavady, Pallippad</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Government bulldozed three farm laws, agriculture can't be run sitting in Delhi: Sharad Pawar</strong> - The NCP supremo said the Centre has passed farm bills on the basis of their own strength in Parliament, didn’t consult the States and that's why all the problems started</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>No mutation in virus reported in Kerala: Minister</strong> - ‘State on high alert and ready to meet any situation’</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Services of fully reserved special trains extended</strong> - Hinting at further delay in restoring normal train services in the railway network, the Railways have extended fully reserved special trains, includi</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russian Covid deaths three times the official toll</strong> - The country's deputy prime minister reveals more than 80% of excess deaths are linked to coronavirus.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pierre Cardin: French fashion giant dies aged 98</strong> - He helped revolutionise fashion with his futuristic and stylish designs in the 1950s and 60s.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cardin: Futuristic man of fashion</strong> - The legendary French fashion designer will be remembered for his futuristic designs and huge range.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bell stolen by Nazis to be returned to Poland</strong> - A Polish church pastor has spent two years looking for the bell, which dates back to 1555.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Spain to keep register of those who refuse Covid vaccine</strong> - Vaccination will not be mandatory, officials say, and the register will not be made public.</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The best accessories and MagSafe gear for your new iPhone 12</strong> - We tested the latest MagSafe cases, stands, and mounts—and some tried and true favorites. - <a href="https://arstechnica.com/?p=1731447">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why AI is so power-hungry</strong> - It takes a lot of energy for machines to be trained with data sets. - <a href="https://arstechnica.com/?p=1732190">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How your digital trails wind up in the hands of the police</strong> - Phone calls. Web searches. Location tracks. Smart speaker requests. - <a href="https://arstechnica.com/?p=1732186">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>All I want for Christmas is an awesome new curriculum</strong> - Revitalizing a curriculum in the middle of a chaos-inducing pandemic? Sure. - <a href="https://arstechnica.com/?p=1731628">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antibodies and SARS-CoV-2 infections: The more the better</strong> - Oxford University Hospital tracked infections in 12,500 of its healthcare workers. - <a href="https://arstechnica.com/?p=1732205">link</a></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
 <ul>
 <li><strong>A local business was looking for office help. They put a sign in the window saying: "HELP WANTED. Must be able to type, must be good with a computer and must be bilingual. We are an Equal Opportunity Employer."</strong> - <!-- SC_OFF -->
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 A short time afterwards, a dog trotted up to the window, saw the sign and went inside. He looked at the receptionist and wagged his tail, then walked over to the sign, looked at it and whined. Getting the idea, the receptionist got the office manager. The office manager looked at the dog and was surprised, to say the least. However, the dog looked determined, so he led him into the office.
 </p>
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 Inside, the dog jumped up on the chair and stared at the manager. The manager said, "I can't hire you. The sign says you have to be able to type." The dog jumped down, went to the typewriter and proceeded to type out a perfect letter. He took out the page and trotted over to the manager and gave it to him, then jumped back on the chair. The manager was stunned, but then told the dog, "The sign says you have to be good with a computer." The dog jumped down again and went to the computer. The dog proceeded to demonstrate his expertise with various programs and produced a sample spreadsheet and database and presented them to the manager. By this time the manager was totally dumbfounded! He looked at the dog and said, "I realize that you are a very intelligent dog and have some interesting abilities. However, I still can't give you the job." The dog jumped down and went to a copy of the sign and put his paw on the part about being an Equal Opportunity Employer. The manager said, "Yes, but the sign also says that you have to be bilingual."
 </p>
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 The dog looked at him straight in the face and said, "Meow."
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/throughmethroughyou"> /u/throughmethroughyou </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/klzneg/a_local_business_was_looking_for_office_help_they/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/klzneg/a_local_business_was_looking_for_office_help_they/">[comments]</a></span></p></li>
 <li><strong>A shooting club was holding a competition. The winner was to get a somewhat ugly trophy, the second-placed shooter - a crate of champagne.</strong> - <!-- SC_OFF -->
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 By the end of the final round, two shooters were tied for first place, so they were told to do a tiebreaker round - 5 shots at maximum distance. To keep things more dramatic, they had to shoot at the same time.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 After both had stopped firing and were awaiting the results, one shooter turned to his rival and said with a little smile: "I'm sorry, pal. I put all five shots in the wall."
 </p>
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 "I'm sorry, too," replied the other, "because I put all of mine into your target."
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/NorthernStarLV"> /u/NorthernStarLV </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/km43wl/a_shooting_club_was_holding_a_competition_the/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/km43wl/a_shooting_club_was_holding_a_competition_the/">[comments]</a></span></p></li>
 <li><strong>I proposed to my Russian girlfriend and she said yes!</strong> - <!-- SC_OFF -->
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 I proposed to my Russian girlfriend and she said Yes!
 </p>
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 For the wedding, my whole family and friends flew over to her home town of Moscow.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 It was a beautiful ceremony, however I did find some things strange. For instance, the priest never said, "You may now kiss the bride", but I just assumed it was purely an American thing and didn't mind.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Later during the reception, we were both starving and decided to head over to the buffet to get food. On the way we passed the drink table, where about six people were waiting to get a fruity drink from a bowl.
 </p>
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 As we passed, they all said in unison, "You may now kiss the bride!" My wife got giddy and gave me a big kiss, which I of course returned.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 As we walked away I asked, "Why did <em>they</em> tell us to kiss and not the priest?"
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 My wife answered,
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 "In Soviet Russia, the punchline tells you!"
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/coolfunaboud"> /u/coolfunaboud </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/km88ff/i_proposed_to_my_russian_girlfriend_and_she_said/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/km88ff/i_proposed_to_my_russian_girlfriend_and_she_said/">[comments]</a></span></p></li>
 <li><strong>A very attractive girl goes to confession (NSFW)</strong> - <!-- SC_OFF -->
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "Forgive me Father for I have sinned"
 </p>
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 Priest: "What did you do Child?"
 </p>
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 Girl: "I called a man a son of a bitch."
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 Priest: "Why did you call him a son of a bitch?"
 </p>
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 Girl: "Because he touched my hand."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "Like this?" (as he touches her hand)
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 Girl: "Yes father."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "That's no reason to call a man a son of a bitch."
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "Then he touched my breast."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "Like this?" (as he touched her breast)
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "Yes father."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "That's no reason to call him a son of a bitch."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "Then he took off my clothes, father."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "Like this?" (as he takes off her clothes)
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "Yes father."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "That's no reason to call him a son of a bitch."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "Then he stuck his you know what into my you know where."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "Like this?" (as he stuck his you know what into her you know where)
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "YES FATHER, YES FATHER, YES FATHER!!!"
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: (after a few minutes): "That's no reason to call him a son of a bitch."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Girl: "But father he had AIDS!"
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Priest: "THAT SON OF A BITCH!!!"
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/S2Charlie"> /u/S2Charlie </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/klsmpy/a_very_attractive_girl_goes_to_confession_nsfw/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/klsmpy/a_very_attractive_girl_goes_to_confession_nsfw/">[comments]</a></span></p></li>
 <li><strong>Several years ago, Andy was sentenced to prison. During his stay, he got along well with the guards and all his fellow inmates. The warden saw that deep down, Andy was a good person and made arrangements for Andy to learn a trade while doing his time.</strong> - <!-- SC_OFF -->
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 After three years, Andy was recognized as one of the best carpenters in the local area.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Often he would be given a weekend pass to do odd jobs for the citizens of the community and he always reported back to prison before Sunday night was over.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The warden was thinking of remodeling his kitchen and in fact had done much of the work himself.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 But he lacked the skills to build a set of kitchen cupboards and a large counter top, which he had promised his wife.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 So he called Andy into his office and asked him to complete the job for him.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 But, alas, Andy refused.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 He told the warden, "Gosh, I'd really like to help you but counter fitting is what got me into prison in the first place."
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/honolulu_oahu_mod"> /u/honolulu_oahu_mod </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kmcf6r/several_years_ago_andy_was_sentenced_to_prison/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kmcf6r/several_years_ago_andy_was_sentenced_to_prison/">[comments]</a></span></p></li>
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 <h2 id="daily-dose">Daily Dose</h2>
-<ul id="daily-dose-list"><li><a href="./archive-daily-dose/28 December, 2020.html">28 December, 2020</a></li><li><a href="./archive-daily-dose/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-daily-dose/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-daily-dose/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-daily-dose/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-daily-dose/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-daily-dose/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-daily-dose/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-daily-dose/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-daily-dose/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-daily-dose/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-daily-dose/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-daily-dose/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-daily-dose/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-daily-dose/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-daily-dose/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-daily-dose/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-daily-dose/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-daily-dose/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-daily-dose/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-daily-dose/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
+<ul id="daily-dose-list"><li><a href="./archive-daily-dose/29 December, 2020.html">29 December, 2020</a></li><li><a href="./archive-daily-dose/28 December, 2020.html">28 December, 2020</a></li><li><a href="./archive-daily-dose/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-daily-dose/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-daily-dose/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-daily-dose/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-daily-dose/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-daily-dose/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-daily-dose/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-daily-dose/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-daily-dose/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-daily-dose/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-daily-dose/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-daily-dose/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-daily-dose/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-daily-dose/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-daily-dose/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-daily-dose/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-daily-dose/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-daily-dose/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-daily-dose/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-daily-dose/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
 </ul>
 <h2 id="covid-19">Covid-19</h2>
-<ul id="covid-19-list"><li><a href="./archive-covid-19/28 December, 2020.html">28 December, 2020</a></li><li><a href="./archive-covid-19/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-covid-19/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-covid-19/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-covid-19/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-covid-19/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-covid-19/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-covid-19/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-covid-19/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-covid-19/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-covid-19/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-covid-19/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-covid-19/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-covid-19/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-covid-19/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-covid-19/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-covid-19/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-covid-19/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-covid-19/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-covid-19/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-covid-19/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
+<ul id="covid-19-list"><li><a href="./archive-covid-19/29 December, 2020.html">29 December, 2020</a></li><li><a href="./archive-covid-19/28 December, 2020.html">28 December, 2020</a></li><li><a href="./archive-covid-19/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-covid-19/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-covid-19/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-covid-19/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-covid-19/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-covid-19/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-covid-19/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-covid-19/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-covid-19/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-covid-19/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-covid-19/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-covid-19/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-covid-19/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-covid-19/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-covid-19/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-covid-19/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-covid-19/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-covid-19/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-covid-19/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-covid-19/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
 </ul>
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