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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Potential role of host-mediated RNA editing in intra-host variability of SARS-CoV-2 genomes</strong> -
<div>
Since its zoonotic transmission in the human host, the SARS-CoV-2 virus has infected millions and has diversified extensively. A hallmark feature of viral system survival is their continuous evolution and adaptation within the host. RNA editing via APOBEC and ADAR family of enzymes has been recently implicated as the major driver of intra-host variability of the SARS-CoV-2 genomes. Analysis of the intra-host single-nucleotide variations (iSNVs) in SARS-CoV-2 genomes at spatio-temporal scales can provide insights on the consequence of RNA editing on the establishment, spread and functional outcomes of the virus. In this study, using 1,347 transcriptomes of COVID-19 infected patients across various populations, we find variable prevalence of iSNVs with distinctly higher levels in Indian population. Our results also suggest that iSNVs can likely establish variants in a population. These iSNVs may also contribute to key structural and functional changes in the Spike protein that confer antibody resistance.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.09.417519v2" target="_blank">Potential role of host-mediated RNA editing in intra-host variability of SARS-CoV-2 genomes</a>
</div></li>
<li><strong>Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity</strong> -
<div>
To dissect the mechanisms underlying the inflation of variants in the SARS-CoV-2 genome, we present one of the largest up-to-date analyses of intra-host genomic diversity, which reveals that most samples present heterogeneous genomic architectures, due to the interplay between host-related mutational processes and transmission dynamics. The deconvolution of the set of intra-host minor variants unveils the existence of non overlapping mutational signatures related to specific nucleotide substitutions, which prove that distinct hosts respond differently to SARS-CoV-2 infections, and which are likely ruled by APOBEC, Reactive Oxygen Species (ROS) and ADAR. Thanks to a corrected-for-signatures dN/dS analysis we demonstrate that the mutational processes underlying such signatures are affected by purifying selection, with important exceptions. In fact, several mutations linked to low-rate mutational processes appear to transit to clonality in the population, eventually leading to the definition of new clonal genotypes and to a statistically significant increase of overall genomic diversity. Importantly, the analysis of the phylogenetic model shows the presence of multiple homoplasies, due to mutational hotspots, phantom mutations or positive selection, and supports the hypothesis of transmission of minor variants during infections. Overall, the results of this study pave the way for the integrated characterization of intra-host genomic diversity and clinical outcome of SARS-CoV-2 hosts.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.07.06.189944v2" target="_blank">Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity</a>
</div></li>
<li><strong>In silico design of Multi-epitope-based peptide vaccine against SARS-CoV-2 using its spike protein</strong> -
<div>
SARS-CoV-2 has been efficient in ensuring that many countries are brought to a standstill. With repercussions ranging from rampant mortality, fear, paranoia, and economic recession, the virus has brought together countries to look at possible therapeutic countermeasures. With prophylactic interventions possibly months away from being particularly effective, a slew of measures and possibilities concerning the design of vaccines are being worked upon. We attempted a structure-based approach utilizing a combination of epitope prediction servers and Molecular dynamic (MD) simulations to develop a multi-epitope-based subunit vaccine that involves the two subunits of the spike glycoprotein of SARS-CoV-2 (S1 and S2) coupled with a substantially effective chimeric adjuvant to create stable vaccine constructs. The designed constructs were evaluated based on their docking with Toll-Like Receptor (TLR) 4. Our findings provide an epitope-based peptide fragment that can be a potential candidate for the development of a vaccine against SARS-CoV-2. Recent experimental studies based on determining immunodominant regions across the spike glycoprotein of SARS-CoV-2 indicate the presence of the predicted epitopes included in this study.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.04.23.055467v4" target="_blank">In silico design of Multi-epitope-based peptide vaccine against SARS-CoV-2 using its spike protein</a>
</div></li>
<li><strong>Making the invisible enemy visible</strong> -
<div>
During the COVID-19 pandemic, structural biologists rushed to solve the structures of the 28 proteins encoded by the SARS-CoV-2 genome in order to understand the viral life cycle and enable structure-based drug design. In addition to the 204 previously solved structures from SARS-CoV-1, 548 structures covering 16 of the SARS-CoV-2 viral proteins have been released in a span of only 6 months. These structural models serve as the basis for research to understand how the virus hijacks human cells, for structure-based drug design, and to aid in the development of vaccines. However, errors often occur in even the most careful structure determination - and may be even more common among these structures, which were solved quickly and under immense pressure. The Coronavirus Structural Task Force has responded to this challenge by rapidly categorizing, evaluating and reviewing all of these experimental protein structures in order to help downstream users and original authors. In addition, the Task Force provided improved models for key structures online, which have been used by Folding@Home, OpenPandemics, the EU JEDI COVID-19 challenge and others.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.10.07.307546v2" target="_blank">Making the invisible enemy visible</a>
</div></li>
<li><strong>Proteoforms of the SARS-CoV-2 nucleocapsid protein are primed to proliferate the virus and attenuate the antibody response</strong> -
<div>
The SARS-CoV-2 nucleocapsid (N) protein is the most immunogenic of the structural proteins and plays essential roles in several stages of the virus lifecycle. It is comprised of two major structural domains: the RNA binding domain, which interacts with viral and host RNA, and the oligomerization domain which assembles to form the viral core. Here, we investigate the assembly state and RNA binding properties of the full-length nucleocapsid protein using native mass spectrometry. We find that dimers, and not monomers, of full-length N protein bind RNA, implying that dimers are the functional unit of ribonucleoprotein assembly. In addition, we find that N protein binds RNA with a preference for GGG motifs which are known to form short stem loop structures. Unexpectedly, we found that N undergoes proteolytic processing within the linker region, separating the two major domains. This process results in the formation of at least five proteoforms that we sequenced using electron transfer dissociation, higher-energy collision induced dissociation and corroborated by peptide mapping. The cleavage sites identified are in highly conserved regions leading us to consider the potential roles of the resulting proteoforms. We found that monomers of N-terminal proteoforms bind RNA with the same preference for GGG motifs and that the oligomeric state of a C-terminal proteoform (N156-419) is sensitive to pH. We then tested interactions of the proteoforms with the immunophilin cyclophilin A, a key component in coronavirus replication. We found that N1-209 and N1-273 bind directly to cyclophilin A, an interaction that is abolished by the approved immunosuppressant drug cyclosporin A. In addition, we found the C-terminal proteoform N156-419 generated the highest antibody response in convalescent plasma from patients &gt;6 months from initial COVID-19 diagnosis when compared to the other proteoforms. Overall, the different interactions of N proteoforms with RNA, cyclophilin A, and human antibodies have implications for viral proliferation and vaccine development.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.10.06.328112v2" target="_blank">Proteoforms of the SARS-CoV-2 nucleocapsid protein are primed to proliferate the virus and attenuate the antibody response</a>
</div></li>
<li><strong>IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition</strong> -
<div>
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) are thought to restrict numerous viral pathogens including severe acute respiratory syndrome coronaviruses (SARS-CoVs). However, most evidence comes from single-round pseudovirus infection studies of cells that overexpress IFITMs. Here, we verified that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. Strikingly, however, endogenous IFITM expression was essential for efficient infection of genuine SARS-CoV-2 in human lung cells. Our results indicate that the SARS-CoV-2 Spike protein interacts with IFITMs and hijacks them for efficient viral entry. IFITM proteins were expressed and further induced by interferons in human lung, gut, heart and brain cells. Intriguingly, IFITM-derived peptides and targeting antibodies inhibited SARS-CoV-2 entry and replication in human lung cells, cardiomyocytes and gut organoids. Our results show that IFITM proteins are important cofactors for SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and suitable targets for therapeutic approaches.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.08.18.255935v2" target="_blank">IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition</a>
</div></li>
<li><strong>Are the emerging SARS-COV-2 mutations friend or foe?</strong> -
<div>
The rapid spread of the virus in the community and the widely applied anti-viral treatments may cause new mutations in the virus. This situation raises concerns that potentially more virulent strains with higher mortality rates or the emergence of treatment-resistant strains. SARS-CoV-2 mutates regularly, acquiring about one new mutation in its genome every two weeks. Following rapid spread the original Wuhan form of the virus globally in early 2020, D614G variant of the virus become the dominant form of the virus. While concerns about the D614G variant continue to be debated, the latest UK variant, N501Y, has sparked serious controversy regarding the evolution of the virus, especially at a time when vaccines were available. In this article, the importance of existing mutations in the virus is analyzed in the light of the available data and predictions for the future are discussed.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/zgmk4/" target="_blank">Are the emerging SARS-COV-2 mutations friend or foe?</a>
</div></li>
<li><strong>Measuring COVID-19 Fear and Threat in Australian, Indian, and Nepali University Students</strong> -
<div>
The present study describes the adaption and validation of a brief measure of contagion-related fear and threat in Australian, Indian, and Nepali university students in Australia at the height of the first wave of the COVID-19 pandemic. Adapted from Ho, Kwong-Lo, Mak, and Wong’s (2005) SARS-related fear scale, the Contagion Fear and Threat Scale (CFTS) was rapidly adapted to capture the experience of COVID-19 pandemic-related fear. The factor structure and validity of the 6-item scale were established among Australian (n=155), Indian (n=111), and Nepali (n=148) university students studying in Australia in May-June 2020. Factor analysis revealed two 3-item factors in the Australian student sample: Fear of Infection and Existential Threat. These factors were confirmed in the Indian and Nepali student samples and mirror those found by the Ho et al. (2005) in their original instrument. The convergent and discriminant validity of the full CFTS, Fear of Infection, and Existential Threat scales are indicated via correlations with established measures of depression, anxiety, stress, subjective wellbeing, and religiosity. Differences in the performance of the Fear of Infection and Existential Threat scales are considered in terms of the respective objective and subjective nature of the constructs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/4s65q/" target="_blank">Measuring COVID-19 Fear and Threat in Australian, Indian, and Nepali University Students</a>
</div></li>
<li><strong>Receipt, spending, and clinical correlates of economic impact payments among middle and low-income U.S. adults</strong> -
<div>
This study examined characteristics and planned expenses of U.S. adults who received the economic impact payment (EIP) during the coronavirus disease 2019 (COVID-19) pandemic. Using a nationally representative sample of 6,607 low and middle-income U.S. adults, this study examined the proportion and correlates of EIP receipt among eligible adults; and associations between planned expenses using the EIP, problems paying expenses, and clinical characteristics. In the total sample, 79% reported they received the EIP and 82% of recipients reported the EIP had a positive impact on their life. Being a veteran (OR= 2.59), married (OR= 1.82), with a history of schizophrenia-spectrum disorder (OR= 1.74) or posttraumatic stress disorder (OR= 1.51), and screening negative for recent suicidal ideation (OR= 0.49) were associated with EIP receipt. Planned expenses using the EIP for savings, paying debt, and rent accounted for 63% of the total amount. Greater planned expenses on substance use or gambling were correlated with lower rated impact of the EIP on life. Additionally, EIP receipt was associated with fewer problems paying daily expenses, but participants who screened positive for mental health or alcohol use problems were more likely to report problems paying daily expenses in the past month. Together, these findings suggest unconditional cash transfers, like the EIP, are important for low and middle-income populations to sustain their living situation. The management of funds are important to consider, especially among those experiencing mental health problems, and may represent opportunities for financial literacy and money management interventions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/tpvbs/" target="_blank">Receipt, spending, and clinical correlates of economic impact payments among middle and low-income U.S. adults</a>
</div></li>
<li><strong>Māori and Pacific People in New Zealand have higher risk of hospitalisation for COVID-19</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Aims. We aim to quantify differences in clinical outcomes from COVID-19 infection by ethnicity with a focus on risk of hospitalisation. Methods. We used data on age, ethnicity, deprivation index, pre-existing health conditions, and clinical outcomes on 1,829 COVID-19 cases reported in New Zealand. We used a logistic regression model to calculate odds ratios for the risk of hospitalisation by ethnicity. We also consider length of hospital stay and risk of fatality. Results. Māori have 2.5 times greater odds of hospitalisation than non-Māori, non-Pacific people, after controlling for age and pre-existing conditions. Similarly, Pacific people have 3 times greater odds. Conclusions. Structural inequities and systemic racism in the healthcare system mean that Māori and Pacific communities face a much greater health burden from COVID-19. Older people and those with pre-existing health conditions are also at greater risk. This should inform future policy decisions including prioritising groups for vaccination.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.25.20248427v1" target="_blank">Māori and Pacific People in New Zealand have higher risk of hospitalisation for COVID-19</a>
</div></li>
<li><strong>In silico evaluation of isatin-based derivatives with RNA-dependent RNA polymerase of the novel coronavirus SARS-CoV-2</strong> -
<div>
Isatin (1H-indole-2,3-dione)-containing compounds have been shown to possess several remarkable biological activities. We had previously explored a few isatin-based imidazole derivatives for their predicted dual activity against both inflammation and cancer. We explored 47 different isatin-based derivatives (IBDs) for other potential biological activities using in silico tools and found them to possess anti-viral activity. Using AUTODOCK tools, the binding site, binding energy, inhibitory constant/Ki and receptor-ligand interactions for each of the compounds was analyzed against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). The partition coefficient (logP) values were predicted using MedChem Designer tool. Based on the best Ki, binding energy and the ideal range of logP (between 1.0-3.0), 10 out of total 47 compounds were deemed to be prospective RdRp inhibitors. Some of these compounds gave better Ki, binding energy and logP values when compared to standard RdRp inhibitors such as remdesivir (Ki = 15.61 μM, logP = 2.2; binding energy = -6.95), a clinically approved RdRp inhibitor which is widely used for critical care of COVID-19 patients. The same in silico parameters were assessed for 9 other popular RdRp inhibitors (other than remdesivir), which were earlier used to target RdRp of other viruses, and are now repurposed to target SARS-CoV-2 RdRp. The results showed that the 10 selected isatin-based derivatives (IBDs) could be further explored for activity against SARS-Cov-2. In the present study we evaluated the efficacy of these compounds in silico.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/rkz9n/" target="_blank">In silico evaluation of isatin-based derivatives with RNA-dependent RNA polymerase of the novel coronavirus SARS-CoV-2</a>
</div></li>
<li><strong>Did people really drink bleach to prevent COVID-19? A tale of problematic respondents and a guide for measuring rare events in survey data</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Society is becoming increasingly dependent on survey research. However, surveys can be impacted by participants who are non-attentive, respond randomly to survey questions, and misrepresent who they are and their true attitudes. The impact that such respondents can have on public health research has rarely been systematically examined. In this study we examine whether Americans began to engage in dangerous cleaning practices to avoid Covid-19 infection. Prior reports have suggested that people began to engage in highly dangerous cleaning practices during the Covid-19 pandemic, including ingesting household cleansers such as bleach. In a series of studies totaling close to 1400 respondents, we show that 80-90% of reports of household cleanser ingestion are made by problematic respondents. These respondents report impossible claims such as "recently having had a fatal heart attack" and "eating concrete for its iron content" at a similar rate to ingesting household cleaners. Additionally, respondents frequent misreading or misinterpreting the intent of questions accounted for the rest of such claims. Once inattentive, mischievous, and careless respondents are taken out of the analytic sample we find no evidence that people ingest cleansers. The relationship between dangerous cleaning practices and health outcomes also becomes non-significant once problematic respondents are taken out of the analytic sample. These results show that reported ingestion of household cleaners and other similar dangerous practices are an artifact of problematic respondent bias. The implications of these findings for public health and medical survey research, as well as best practices for avoiding problematic respondents in surveys are discussed.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.11.20246694v2" target="_blank">Did people really drink bleach to prevent COVID-19? A tale of problematic respondents and a guide for measuring rare events in survey data</a>
</div></li>
<li><strong>Relationships of total COVID-19 cases and deaths with ten demographic, economic and social indicators</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The statistical relationships of total COVID-19 Cases and Deaths per million populations in 45 countries, where 85.8% of the world9s population lives with 10 demographic, economic and social indicators were studied. Data for 28 May 2020 were used in the main calculations. The relationship of Deaths per million population and total Cases per million population is very close and reaches correlation coefficient R = 0.926. It is interesting that the close correlations were found of Cases and Deaths per 1 million with a purely economic index like GDP PPP per capita, where R = 0.687 and R = 0.660, respectively. Even more close correlations were found of Cases and Deaths per 1 million with a composite index HDI, where the correlation coefficients reach 0.724 and 0.680, respectively. The main reason for these paradoxical results is the underestimation of pandemic restrictions in the form of masks, social distance and disinfection in most of these countries. Other indicators (excluding Gini index and Population Density) also show statistically significant correlations with Cases and Deaths per 1 million with correlation coefficients from 0.432 to 0.634. The statistical significance of the found correlations determined using Student9s t-test was p &lt;0.0001. Surprisingly, there was no statistically significant correlation between Cases and Deaths with Population Density. To check whether there is a change in the correlations with the development of the pandemic, a statistical analysis was made for four different dates - 9 April, 28 May, 7 August and 30 November 2020. It was found that the correlation coefficients of COVID-19 cases and Deaths with the rest indicators decrease during the pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.09.05.20188953v2" target="_blank">Relationships of total COVID-19 cases and deaths with ten demographic, economic and social indicators</a>
</div></li>
<li><strong>The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies</strong> -
<div>
Small molecule inhibitors have previously been investigated in different studies as possible therapeutics in the treatment of SARS-CoV-2. In the current drug repurposing study, we identified the leukotriene (D4) receptor antagonist Montelukast as a novel agent that simultaneously targets two important drug targets of SARS-CoV-2. We initially demonstrated the dual inhibition profile of Montelukast through multiscale molecular modeling studies. Next, we characterized its effect on both targets by different in vitro experiments including the Fluorescent Resonance Energy Transfer (FRET)-based main protease enzyme inhibition assay, surface plasmon resonance (SPR) spectroscopy, pseudovirus neutralization on HEK293T / hACE2, and virus neutralization assay using xCELLigence MP real time cell analyzer. Our integrated in silico and in vitro results confirmed the dual potential effect of the Montelukast both on virus entry into the host cell (Spike/ACE2) and on the main protease enzyme inhibition. The virus neutralization assay results showed that while no cytotoxicity of the Montelukast was observed at 12 micro-molar concentration, the cell index time 50 (CIT50) value was delayed for 12 hours. Moreover, it was also shown that Favipiravir, a well-known antiviral used in COVID-19 therapy, should be used by 16-fold higher concentrations than Montelukast in order to have the same effect of Montelukast. The rapid use of new small molecules in the pandemic is very important today. Montelukast, whose pharmacokinetic and pharmacodynamic properties are very well characterized and has been widely used in the treatment of asthma since 1998, should urgently be completed in clinical phase studies and if its effect is proven in clinical phase studies, it should be used against COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.26.424423v1" target="_blank">The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies</a>
</div></li>
<li><strong>The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins</strong> -
<div>
The coronavirus nucleocapsid protein (N) controls viral genome packaging and contains numerous phosphorylation sites located within unstructured regions. Phosphorylated SARS-CoV N was shown to bind to the host 14-3-3 protein in the cytoplasm. Proteomic data indicate that seven human 14-3-3 proteins are highly abundant in human tissues vulnerable to SARS-CoV-2 infection, collectively reaching ~1.8% of all proteins in the lungs, ~1.4% in the gastrointestinal system, ~2.3% in the nervous system. Although the association between 14-3-3 and SARS-CoV-2 N proteins can represent one of the key host-pathogen interactions, its mechanism and the specific critical phosphosites were unknown. Here, we show that phosphorylated SARS-CoV-2 N protein (pN) dimers, reconstituted via bacterial co-expression with protein kinase A, directly associate, in a phosphorylation-dependent manner, with the dimeric 14-3-3 protein hub, but not with its monomeric mutant. We demonstrate that pN is recognized by all seven human 14-3-3 isoforms with various efficiencies and determine the apparent KD to selected isoforms in a low micromolar range. Serial truncations pinpointed a critical phosphorylation site to Ser197, located within the SR-rich region of N. The tight 14-3-3/pN association suggests it could regulate nucleocytoplasmic shuttling of N, while hijacking cellular pathways by 14-3-3 sequestration. As such, the assembly may represent a valuable target for therapeutic intervention.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.26.424450v1" target="_blank">The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Changes in Viral Load in COVID-19 After Probiotics</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Dietary Supplement: Dietary supplementation in patients with covid disease admitted to hospital<br/><b>Sponsors</b>:   Hospital de Sagunto;   Biopolis S.L.;   Laboratorios Heel España<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dendritic Cell Vaccine to Prevent COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: AV-COVID-19<br/><b>Sponsors</b>:   Indonesia-MoH;   Aivita Biomedical, Inc.;   PT AIVITA Biomedika Indonesia;   National Institute of Health Research and Development, Ministry of Health Republic of Indonesia;   RSUP Dr. Kariadi Semarang, indonesia;   Faculty of Medicine University of Diponegoro, Indonesia<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (SARS-CoV-2 Infected)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: AZVUDINE;   Drug: AZVUDINE placebo<br/><b>Sponsors</b>:   HRH Holdngs Limited;   GALZU INSTITUTE OF RESEARCH, TEACHING, SCIENCE AND APPLIED TECHNOLOGY, Brazil;   SANTA CASA DE MISERICORDIA DE CAMPOS HOSPITAL (SCMCH), Brazil;   UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE (UENF), Brazil<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhaled Ivermectin and COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ivermectin Powder<br/><b>Sponsor</b>:   Mansoura University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mushroom-based Product for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: FoTv<br/><b>Sponsors</b>:   Gordon Saxe;   University of California, Los Angeles;   University of California, Irvine<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Investigate the Treatment Effect of Colchicine in Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Colchicine;   Drug: Standard COVID-19 care<br/><b>Sponsors</b>:   Ayub Teaching Hospital;   Universidad de Murcia<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of hzVSF-v13 in Patients With COVID-19 Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: hzVSF-v13;   Drug: Placebo (Normal saline solution)<br/><b>Sponsor</b>:   ImmuneMed, Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of hzVSFv13 in Patients With COVID-19 Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: hzVSF-v13;   Drug: Placebo (Normal saline solution)<br/><b>Sponsor</b>:   ImmuneMed, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity Study of AdCLD-CoV19: A COVID-19 Preventive Vaccine in Healthy Volunteers</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: AdCLD-CoV19<br/><b>Sponsor</b>:   Cellid Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of hzVSF-v13 in Moderate to Severe Patients With COVID-19 Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: hzVSF-v13;   Drug: Placebo (Normal saline solution)<br/><b>Sponsor</b>:   ImmuneMed, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AZD1222 Vaccine in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AZD1222;   Biological: rAd26-S<br/><b>Sponsors</b>:   AstraZeneca;   R-Pharm<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AS03-adjuvanted SCB-2019 vaccine;   Biological: Placebo; 0.9% saline<br/><b>Sponsors</b>:   Clover Biopharmaceuticals AUS Pty Ltd;   The Coalition for Epidemic Preparedness Innovations;   International Vaccine Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Assess the Virologic Efficacy of REGN10933+REGN10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: REGN10933+REGN10987 combination therapy;   Drug: Placebo<br/><b>Sponsor</b>:   Regeneron Pharmaceuticals<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the Efficacy of High Doses of Methylprednisolone in SARS-CoV2 ( COVID-19) Pneumonia Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Methylprednisolone, Placebo<br/><b>Sponsor</b>:   Azienda Unità Sanitaria Locale Reggio Emilia<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Ivermectin;   Drug: Hydroxychloroquine;   Behavioral: personal protective Measures<br/><b>Sponsor</b>:   Benha University<br/><b>Completed</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Tocilizumab in COVID-19 patients: a cohort study</strong> - CONCLUSIONS: Majority of patients demonstrated clinical improvement and were successfully discharged alive from the hospital after receiving tocilizumab. We observed a rebound effect with CRP, which may suggest the need for higher or subsequent doses to adequately manage cytokine storm. Based on our findings, we believe that tocilizumab may have a role in the early treatment of COVID-19, however larger randomized controlled studies are needed to confirm this.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19</strong> - CONCLUSION: The in vitro activity of GaM against SARS-CoV-2, together with GaM's known anti-inflammatory activity, provide justification for testing GaM in COVID-19 patients.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform</strong> - BACKGROUND: Hydroxychloroquine has been shown to inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro, but clinical studies found no evidence of reduced mortality when treating patients with COVID-19. We aimed to evaluate the effectiveness of hydroxychloroquine for prevention of COVID-19 mortality, as opposed to treatment for the disease.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of FDA approved drugs and nucleoside analogues as potential SARS-CoV-2 A1pp domain inhibitor: An in silico study</strong> - Coronaviruses are known to infect respiratory tract and intestine. These viruses possess highly conserved viral macro domain A1pp having adenosine diphosphate (ADP)-ribose binding and phosphatase activity sites. A1pp inhibits adenosine diphosphate (ADP)-ribosylation in the host and promotes viral infection and pathogenesis. We performed in silico screening of FDA approved drugs and nucleoside analogue library against the recently reported crystal structure of SARS-CoV-2 A1pp domain. Docking...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA</strong> - Self-amplifying RNA (saRNA) is a cutting-edge platform for both nucleic acid vaccines and therapeutics. saRNA is self-adjuvanting, as it activates types I and III interferon (IFN), which enhances the immunogenicity of RNA vaccines but can also lead to inhibition of translation. In this study, we screened a library of saRNA constructs with cis-encoded innate inhibiting proteins (IIPs) and determined the effect on protein expression and immunogenicity. We observed that the PIV-5 V and Middle East...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure-Based Screening to Discover New Inhibitors for Papain-like Proteinase of SARS-CoV-2: An In Silico Study</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses a multifunctional papain-like proteinase (PLpro), which mediates the processing of the viral replicase polyprotein. Inhibition of PLpro has been shown to suppress the viral replication. This study aimed to explore new anti-PLpro candidates by applying virtual screening based on GRL0617, a known PLpro inhibitor of SARS coronavirus (SARS-CoV). The three-dimensional (3D) structure of SARS-CoV-2 PLpro was built by homology...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A ligand selection strategy identifies chemical probes targeting the proteases of SARS-CoV-2</strong> - Activity-based probes are valuable tools for chemical biology. However, finding probes that specifically target the active site of an enzyme remains a challenging task. Here we present a ligand selection strategy that allows to rapidly tailor electrophilic probes to a target of choice and showcase its application for the two cysteine proteases of SARS-CoV-2 as proof of concept. The resulting probes were specific for the active site labelling of 3CL pro and PL pro with sufficient selectivity in a...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Spiky nanostructures for virus inhibition and infection prevention</strong> - The outbreak of a novel highly infectious virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has aroused people's concern about public health. The lack of ready-to-use vaccines and therapeutics makes the fight with these pathogens extremely difficult. To this point, rationally designed virus entry inhibitors that block the viral interaction with its receptor can be novel strategies to prevent virus infection. For ideal inhibition of the virus, the virus-inhibitor interaction...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The SARS-CoV-2 RNA-protein interactome in infected human cells</strong> - Characterizing the interactions that SARS-CoV-2 viral RNAs make with host cell proteins during infection can improve our understanding of viral RNA functions and the host innate immune response. Using RNA antisense purification and mass spectrometry, we identified up to 104 human proteins that directly and specifically bind to SARS-CoV-2 RNAs in infected human cells. We integrated the SARS-CoV-2 RNA interactome with changes in proteome abundance induced by viral infection and linked interactome...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension</strong> - The coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread to &gt;200 countries posing a global public health concern. Patients with comorbidity, such as hypertension suffer more severe infection with elevated mortality. The development of effective antiviral drugs is in urgent need to treat COVID-19 patients. Here, we report that calcium channel blockers (CCBs), a type of antihypertensive drug that is widely used in clinics,...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beneficial effect of Indigo Naturalis on acute lung injury induced by influenza A virus</strong> - CONCLUSION: The results showed that INAE alleviated IAV induced ALI in mice. The mechanisms of INAE were associated with its anti-influenza, anti-inflammatory and anti-oxidation properties. Indigo Naturalis might have clinical potential to treat ALI induced by IAV.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Action of dipeptidyl peptidase-4 inhibitors on SARS-CoV-2 main protease</strong> - In a recent publication in this journal Eleftheriou et al. proposed inhibitors of dipeptidyl peptidase-4 (DPP-4) to be functional inhibitors of the main protease (M pro ) of SARS-CoV-2. Their predictions prompted the authors to suggest linagliptin, a DPP-4 inhibitor and approved anti-diabetes drug, as a repurposed drug candidate against the ongoing COVID-19 pandemic. We used an enzymatic assay measuring inhibition of M pro catalytic activity in the presence of four different commercially...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"Silent hypoxaemia in COVID-19 patients"</strong> - The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labeled with 'happy hypoxia,' in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recognition of Plausible Therapeutic Agents to Combat COVID-19: An Omics Data Based Combined Approach</strong> - Coronavirus disease-2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has become an immense threat to global public health. In this study, more than 67,000 reference sequences including a complete genome sequence of SARS-CoV-2 isolate performed by us and several in silico techniques were merged to propose prospective therapeutics. Through meticulous analysis, several conserved and therapeutically suitable regions of SARS-CoV-2 such as RNA-dependent RNA...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Understanding the immunopathogenesis of COVID-19: Its implication for therapeutic strategy</strong> - Although 80% of individuals infected with the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) recover without antiviral treatments, the other 20% progress to severe forms of pulmonary disease, suggesting that the host's immune response to the virus could influence the outcome of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects alveolar epithelial type 2 cells expressing angiotensin-converting enzyme 2, and these infected epithelial cells recruit dendritic cells, neutrophils...</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid 19 - Chewing Gum</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313269181">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313300659">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19</strong> - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN313339294">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251184">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251182">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN312324209">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물</strong> - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR313434044">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU311608060">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 RBD共轭纳米颗粒疫苗</strong> - 本发明涉及免疫医学领域，具体而言，涉及一种SARS‑CoV‑2 RBD共轭纳米颗粒疫苗。该疫苗包含免疫原性复合物，所述免疫原性复合物包含：a）与SpyCatcher融合表达的载体蛋白自组装得到的纳米颗粒载体；b）与SpyTag融合表达的SARS‑CoV‑2病毒的RBD抗原；所述载体蛋白选自Ferritin、mi3和I53‑50；所述载体蛋白与所述抗原之间通过SpyCatcher‑SpyTag共价连接。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN313355625">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Устройство электронного контроля и дистанционного управления аппарата искусственной вентиляции легких</strong> - Полезная модель относится к медицинской технике, а именно к устройствам для воздействия на дыхательную систему пациента смесью различных газов, в частности, к устройствам для проведения искусственной вентиляции легких (ИВЛ). Технический результат предлагаемой полезной модели заключается в решении технической проблемы, состоящей в необходимости расширения арсенала технических средств, предназначенных для электронного контроля и управления ИВЛ, путем реализации возможности дистанционного управления аппаратами ИВЛ в медицинских учреждениях, не оборудованных кабельными вычислительными сетями. Указанный технический результат достигается благодаря тому, что в известное устройство электронного контроля и дистанционного управления аппарата ИВЛ, содержащее центральный микроконтроллер, а также программно-аппаратные средства управления функциями доставки воздушной смеси пациенту и многоуровневой тревожной сигнализации об отклонениях от нормативных условий и технических неполадках в аппарате ИВЛ, введены связанные друг с другом микроконтроллер связи и дистанционного управления и радиомодем, выполненный с возможностью связи с точками доступа радиканальной сети, при этом центральный микроконтроллер устройства выполнен с дополнительными входом/выходом, которые связаны с управляющими выходом/входом микроконтроллера связи и дистанционного управления, а, в зависимости от типа применяемой в медицинском учреждении радиоканальной сети связи и передачи данных, радиомодем может быть выполнен в виде интерфейсного аудиомодуля Bluetooth 4.0 BLE, приемопередающего модуля Wi-Fi либо устройства "малого радиуса действия", работающего по технологии LoRa на нелицензируемых частотах мегагерцового диапазона, например, в диапазоне 868 МГц. 3 з.п. ф-лы, 1 ил. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=RU313244211">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Plague Year</strong> - The mistakes and the struggles behind America’s coronavirus tragedy. - <a href="https://www.newyorker.com/magazine/2021/01/04/the-plague-year">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can Wall Street’s Heaviest Hitter Step Up to the Plate on Climate Change?</strong> - More significant than BlackRock executives’s pledges is the firm’s continued inclusion of fossil-fuel companies in its index funds. - <a href="https://www.newyorker.com/news/annals-of-a-warming-planet/can-wall-streets-heaviest-hitter-step-up-to-the-plate-on-climate-change">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump Directs His Wrecking Ball at the COVID-19 Relief Bill and Mitch McConnell</strong> - After a week spent largely out of the public eye, the President reappeared with a flurry of pardons and an attack on the House Speaker’s coronavirus relief bill. - <a href="https://www.newyorker.com/news/our-columnists/trump-directs-his-wrecking-ball-at-the-covid-19-relief-bill-and-mitch-mcconnell">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Georgia Trump Fans Say the Last Election Was a Sham. Will They Vote in This One?</strong> - Kelly Loeffler and David Perdue are trying to placate the President and run for the Senate at the same time. - <a href="https://www.newyorker.com/news/us-journal/georgia-trump-fans-say-the-2020-election-was-a-sham-will-they-vote-in-this-one">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>As the Vaccine Arrives, Death and Denial Rage in a California Coronavirus Epicenter</strong> - In the San Joaquin Valley, medical professionals fear that many in the public still fail to grasp the dangers of COVID-19. - <a href="https://www.newyorker.com/science/medical-dispatch/as-the-vaccine-arrives-death-and-denial-rage-in-a-california-coronavirus-epicenter">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Lost Year: Chronic pain, an unusual love story, and reassurance via pickle</strong> -
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/tWIEMpLVnVVpJFmLcS9LNlEr4eQ=/529x0:4529x3000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68584426/hearts02.0.jpg"/>
<figcaption>
Amanda Northrop/Vox
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“There are certain ways — and maybe it’s not cool to say this — in which quarantine has been helpful.”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HTtuzr">
<em>This is </em><a href="https://www.vox.com/22160175/2020-tarot-covid"><em><strong>The Lost Year</strong></em></a><em>, a series of stories about our lived experiences in 2020, as told to Vox critic at large Emily VanDerWerff.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rZLxqh">
Before Covid-19 hit, Honey rarely left the house. Much of their work as an artist and photographer could happen within their home, and they were used to spending a lot of time alone. Chronic physical and mental conditions made staying at home a strong preference.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6RSoli">
But that hasn’t been true in the midst of the pandemic. In the past nine months, Honey has taken a job with the post office as a delivery driver and gotten married (to someone they met <em>during</em> the pandemic). I’m fascinated by the ways so many of our worlds have shrunk over this period, but Honey’s has actually expanded, to encompass both a spouse and a new job that takes them out on the road a few days a week.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6SGa2M">
I’m also fascinated by Honey’s story of managing a chronic pain condition in the midst of a pandemic, especially when so many of their symptoms present similarly to Covid-19 symptoms. Their solution for making sure they’re “just” suffering from chronic pain and not the virus is clever. Throughout our chat, I was blown away by Honey’s observations on a world in isolation, a world that resembles the one they’ve lived in for most of their life.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IUAtVN">
Here’s Honey’s story, as told to me.
</p>
<hr class="p-entry-hr" id="YtcBjN"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G70SRC">
Before the pandemic, I did a lot of film photography. I was creating all the time. Now, I shifted gears and got into other formats. I’ve been doing a lot of collage work. I’ve been doing sewing and embroidery and stuff. Some people have hired me to do paid photo shoots, and I always tell them I’m going to wear a mask and shoot with my close lens, so I can be far away from them. But I do them. Money’s money.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LQmwUV">
Honestly, changing art forms has been really good for me. I don’t think I would have done it [if not for the pandemic]. I wouldn’t have been able to discover all the things that I can do.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sPn6yw">
My quarantine experience probably hasn’t been like other people’s. Before the pandemic, I didn’t go to parties or anything, and I just left [the house] for things like grocery shopping. I have some mental health conditions, like autism, ADHD, and PTSD, but I also have physical health struggles, like endometriosis and arthritis. Those are definitely a challenge.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="riYWLS">
If anything, there are certain ways — and maybe it’s not cool to say this — in which quarantine has been helpful. When I used to tell people, “Oh, I can’t hang out,” it was much harder to get them to understand why. And now it’s like, “Oh, there’s a pandemic. I can’t come.” And a lot of jobs beforehand were not at all accommodating, or they didn’t have a lot of infrastructure for that. And now if I say that I’m sick and I can’t come in, they’ll say, “Oh, my gosh, stay home!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="INaQfn">
I even got a job as a delivery driver with the post office. So it’s interesting — I’m definitely leaving my house more [than I did before the pandemic], but I’m leaving my house to be alone in a car by myself, which is the ideal situation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1KPHz8">
I live in South Carolina, and in the upstate area [where I live], we shut down for maybe two weeks max. It was so quiet and weird. And a lot of people were home when I would deliver, which I wouldn’t like. But what was <em>really</em> weird was that very shortly after that, everything was back to normal. Everybody was out, like the pandemic didn’t exist. No one was wearing masks. The times when I’m in the building, loading my packages in my truck, I have my mask on. Some of my coworkers do, but most of them absolutely do not wear their masks. And it’s so stressful to me. I want to say something. I’m scared to say something.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eTXeVp">
I think many white people will always see inconvenience as oppression. And it’s not even that much of an inconvenience! They just hate that they have to do what everybody else is doing. They have this obsession with hyper-individualization that carries through not only to wearing a mask like everybody else; hyper-individualization in America also means that you’re responsible for your own health. It’s your fault if you get sick. It’s not my fault for not wearing a mask. You got sick, and that’s on you.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hYWsUX">
I grew up in a very isolated setting, and that prepared me for a lot [of this experience]. My parents had seven kids, and we pretty much didn’t interact with anyone outside our family. It was complete lockdown. I couldn’t watch TV or read unapproved books. So most of the relationships I formed in my life, I’ve formed over the internet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0x5BJJ">
I feel like this pandemic has been less challenging for people who grew up in specifically traumatizing households and people who have certain mental illnesses. For us, it’s often normal to conduct all our relationships over the internet. And some neurotypical people and people who love going out to meet people are having a lot of trouble adjusting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Er4j1v">
I’m living with my wife now, and I’ve been semi on my own since I was 17, but I never had my own space. And now I have my own space. I get to control the experiences I have. I’m just starting with movies and TV and books. There’s no end to the entertainment and the new things I can discover. I just watched an anime called <a href="https://en.wikipedia.org/wiki/Fruits_Basket"><em>Fruits Basket</em></a>. It’s really gay, and it’s awesome.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wL3I5e">
I met my wife at the start of the pandemic, on Tinder. I met them at the perfect time. I was learning a lot of important things on how to be independent, and they, as a person, are extremely independent. We’re around each other, because we enjoy each other’s company, but whenever we need our own space, we just take our own space. There’s a mutual understanding and a flow to it. It helped to almost approach the marriage like a business arrangement and not put pressure and stress on it and see where things went. It progressed very naturally, and it’s easy to be in a relationship with them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wp5ZmC">
Neither of us really believes in marriage, but they are ex-military, and they have health benefits and a retirement fund. I really needed surgery at the time, and it worked out, because we like each other. We met, and we saw each other every day since the first time we met up, and then we got married.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T97t0a">
It’s been good. It’s been pretty easy. We’ve made sure to take precautions. If we mutually agree that we don’t want to be together in a romantic or sexual way, we have everything planned out for that. We’re not stupid.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u7WuyC">
The pandemic has exacerbated certain struggles we have. But because we have different things to manage, there is a balance. I’m able to be there for them, and they’re able to be there for me. The issues that affect me the most right now are my physical issues, and they are affected by their mental issues. So they’re able to help me with physical things, and I can help them with mental things.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RIteSe">
Everything that I deal with — chronic pain, nausea, having trouble moving — mimics the symptoms of Covid-19. And every couple of weeks, I’ll have a freakout and be like, “Oh, my god, what if I have it.” But the one symptom I don’t get with my chronic illnesses is a loss of taste or smell. So if I’m experiencing symptoms, I can easily spiral. “What if the hospital is full? What if the bill is so expensive we can’t pay it?” Just freaking out. So now whenever I start freaking out, I just go eat a pickle or something to calm myself down and reassure myself. But it took me a lot of months to get there!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iuZR87">
One of the biggest struggles has been that both of us are learning we don’t have to hide things from each other. It’s difficult, because we both grew up in environments where we had to hide things, just from us being queer and growing up in very homophobic families. At the beginning, it almost helped with the honesty [between us] being thrust immediately into a situation where we can take our own space if we want, but because of the pandemic, we are like, “Okay, you’re the only person that I’m going to see now.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dRG7Eb">
Knowing we have [a plan] but also being stuck in a house together helps with two things. First, [we have that plan], so I don’t have to be afraid to bring things up to my partner. And second, we are kind of stuck here, so to speak, so me keeping things to myself is stupid and childish. It’s just better to talk it out.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0w5M3R">
<em><strong>Next: </strong></em><em>A new baby who didn’t know your face for days because you were always wearing a mask</em>
</p>
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<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bridgerton has a rape scene, but it’s not treated like one</strong> -
<figure>
<img alt="A couple in Regency clothing link arms and gaze at each other at a ball." src="https://cdn.vox-cdn.com/thumbor/dw_VKMfj2AngxBZYJdncd1CfzJw=/379x0:3584x2404/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68581758/bridg1.0.jpg"/>
<figcaption>
Regé-Jean Page as Simon Basset and Phoebe Dynevor as Daphne Bridgerton in <em>Bridgerton</em>. | Liam Daniel/Netflix
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Bridgerton wants to explore consent while it ignores its own glaring consent issue.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dstiiB">
<em>Bridgerton</em>, Shonda Rimes’s first collaboration with Netflix, may be a sumptuous, scandal-laced frolic through Regency London. But like many Shondaland series, it has plenty of dark and disturbing moments, and the show’s first season leaves us with more questions than answers. Chief among them: Does the creative team realize how badly they handled the rape scene?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WOZQwn">
Romance novelist Julia Quinn wrote the novel series on which <em>Bridgerton</em> is based, starting with <em>The Duke and I</em> in 2000. The first season, written by Shondaland veteran <a href="https://www.imdb.com/name/nm2547449/">Chris Van Dusen</a> (<em>Scandal, Grey’s Anatomy</em>), follows <em>The Duke and I</em> fairly closely — including one scene that’s central to the plot but that has been called out repeatedly by romance readers over the years <a href="https://www.reddit.com/r/BridgertonNetflix/comments/jg36i8/how_will_this_controversial_part_of_the_plot_be/">as a rape</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UcvmU6">
In the two decades since the book’s release, <a href="https://www.vox.com/metoo">much of society</a> has become more aware of what is and isn’t consensual sex, and the show deliberately made changes to the scene to make it less explicitly nonconsensual. That indicates to me that Van Dusen and his fellow creatives knew the problems with the scene they were adapting. But the version of this scene that ended up in the show is still nonconsensual, despite the tweaks. And although it’s framed as a serious violation of trust between consenting parties, it passes without any explicit acknowledgment on the show’s part that what just occurred was a deeply disturbing violation of consent.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pYxx9K">
<em>Bridgerton </em>is thematically concerned with the dynamics of informed consent, which makes it even stranger that this scene was left unaddressed; indeed, if there are any lasting repercussions for the victim of the assault or their dynamic with their rapist, we don’t actually see them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h8lwuF">
Because it happens pretty quickly and the narrative moves on immediately from the specifics of the sexual encounter itself, I’m not sure everyone will judge this scene in the same way I do. But that’s why we should discuss it.
</p>
<figure class="e-image">
<pre><code> &lt;img alt="Spoilers below!" src="https://cdn.vox-cdn.com/thumbor/NRVFKBJOWkX6yayj9JEVuLDSUh4=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/8635113/spoilers_below.png" /&gt;</code></pre>
</figure>
<h3 id="0B7iTy">
Our hero has a secret that sets the stage for everything
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YdTy7I">
<em>Bridgerton </em>is a historical romance set during London’s Regency era, a period of whirling 19th-century ballrooms and high-society intrigues. Our story revolves around gorgeous debutante Daphne Bridgerton (<a href="https://www.imdb.com/name/nm3697443/">Phoebe Dynevor</a>) and the fake courtship she arranges during her debut on London’s “marriage mart,” the upper-class ritual of social functions that help eligible ladies and gentlemen make a match.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IFyokc">
Despite coming from a powerful family and making a splash at her debut, Daphne is having trouble attracting suitors — so she bets (correctly) that faking a courtship with a very eligible duke will reignite the attention of other gentlemen. Her choice of bachelor: Simon, the hunky Duke of Hastings (<a href="https://www.imdb.com/name/nm2074546/?ref_=tt_cl_t20">R</a><a href="https://www.imdb.com/name/nm2074546/">egé-Jean Page</a>), a Black man whose family was recently elevated to the peerage. Simon is trying to avoid matrimonial plots because he’s sworn off marriage, due to his solemn vow never to father children in order to let his entire family line, title and all, die with him. It’s a promise he made in order to spite his abusive late father, who emotionally abused Simon all his life and cared more about his dukedom than anything else.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DraNdG">
The relationship ruse is mutually beneficial for Daphne and Simon, as it allows him to avoid seriously participating in the marriage mart. But of course, in between bickering and pretending to be in love, the two fake lovebirds soon develop a very real romance. Through an unlucky turn of events involving epic misunderstandings, secret love trysts, and a duel — y’know, the usual — the storyline scoots Daphne and Simon into a hastily arranged marriage. This leads to lots and lots of sex scenes because they’re a hot couple who are hot for each other. But their newfound love also creates a whole new set of problems arising from Simon’s vow never to sire a family — a vow Daphne knows nothing about.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nwmUh1">
This subplot contributes to <em>Bridgerton</em>’s most interesting thematic idea, if one it ultimately squanders: the relationship between scandal, secrets, and informed consent. The plot revolves around Simon’s choice not to tell Daphne that he has vowed not to have children. Instead, he only tells her that he “can’t” have children, a clear difference from “won’t.” This deception places her in a doubly vulnerable position: Daphne’s in the dark about sex generally, as a woman who’s had no sexual education, and since she’s getting most of her tutelage from him directly, she has no way of knowing that he’s hiding things from her about his sexual health and practices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BKxHjB">
Simon’s duplicity is, to some extent, unwitting — he doesn’t intend to trap Daphne into marriage, but when events conspire to make marriage a necessity, he goes along with it, spinning a story that implies his inability to father children rather than tell her the truth. The narrative treats the difference between “can’t” and “won’t” as a crucial distinction, one that fills Daphne with horror and bitterness when she realizes it. It’s an interesting turn because <em>Bridgerton</em> frames Simon’s deceptive phrasing as deliberate, along with his choice to continue lying to her by omission. This deception placed Daphne in the position of being unable to give informed consent, either to sex or to their entire relationship.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uA6UhA">
The problem is that she only figures this out by raping him.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UUhJfs">
Let me back up. <strong>(Warning: This is about to get pretty graphic and gross.)</strong>
</p>
<h3 id="FG11zJ">
The rape scene is brief and disturbing, but it’s not treated as a rape
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RSauxb">
Daphne knows nothing about sex when she gets married. Her mother, too embarrassed to give her the specifics, sends her off to her marriage bed completely unprepared. Meanwhile, instead of telling his new wife what’s up, Simon enjoys ravenous sex with Daphne<strong> </strong>but adopts the ol’ tried-and-true contraceptive method of pulling out every time. Eventually, Daphne figures out that there’s some connection between Simon never completing the act and his insistence that he can’t have children. Determined to figure out whether he’s capable of it, she takes control during sex and positions herself on top of him so he can’t pull out.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wZj86M">
When he realizes his predicament right before orgasm, Simon looks alarmed and tries to stop — he cries out twice for Daphne to wait — but it’s too late. Once she’s achieved her goal, she stops, and he processes what just happened in shock.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0M9nPy">
The strangest thing about this moment is that I’m not sure the show’s writers consider<em> </em>this scene to be a rape scene. Daphne is immediately furious with Simon for lying to her, and the show then focuses on her betrayal and rage; she even has a semantic speech about the difference between “won’t” and “can’t.” It’s clearly intended to spell out the intricacies of informed consent, but none of Simon’s duplicity justifies the way Daphne pulls his secret —<strong> </strong>and, to be clear, his semen — out of him. One bad moment of uninformed consent does not justify a moment of nonconsensual sex. And depriving Simon of his consent to both sex and fatherhood, even at the moment of climax, is still rape.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="66bnDU">
If the show had really explored the idea that Simon’s lie led to another similar violation of consent, that could have resulted in some really interesting narrative choices involving the two of them dealing with the fallout of both their betrayals and learning to communicate more clearly and carefully and sensitively.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LZFYew">
But the show doesn’t dwell on Daphne’s choices, or on any long-term aftermath from that moment. The incident doesn’t seem to impact Simon’s ability to trust Daphne in bed. Instead, the show turns toward Daphne’s distrust of him for lying to her, dwelling on Simon’s need to win her forgiveness and give up his vow for the sake of their happiness.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tVcvVa">
I should note here that an <a href="https://bookbinge.com/2013/03/book-club-the-dukes-sperm-tdai/">even more nonconsensual version</a> of this scene also occurs in the novel. Quinn clearly wrote the scenario as a violation: “Daphne had aroused him in his sleep, taken advantage of him while he was still slightly intoxicated, and held him to her while he poured his seed into her.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kQ1kkU">
Since the book was written, countless romance writers and readers have inserted <a href="https://smartbitchestrashybooks.com/2005/09/talking_about_the_r_word/">productive</a> <a href="https://dearauthor.com/features/letters-of-opinion/sexual-force-and-reader-consent-in-romance/">commentaries</a> on <a href="http://www.jprstudies.org/2012/04/a-parody-of-love-the-narrative-uses-of-rape-in-popular-romance-by-angela-toscano/">the role</a> of rape (and tropes of dubious consent like “forced seduction”) in romance fiction. But according to Quinn herself in a <a href="https://www.youtube.com/watch?app=desktop&amp;v=attmZbMFgO0&amp;t=22m10s">reported recent exchange</a> with romance vlogger <a href="https://www.youtube.com/user/krystina885/about">BooksandKrys</a>, the consent issues in that scene flew under the radar at the time <em>The Duke and I</em> was published.<strong> </strong>“Yes, it was shocking, but no one seemed to feel that Daphne had done anything morally wrong,” she told BooksandKrys. “It was only as years passed and we gained new understanding of ‘consent’ that people started to question her actions.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1W2zl3">
Quinn offered some perspective on the dynamics of rape as early as 2003; speaking then to <em>Time</em>, she <a href="http://content.time.com/time/magazine/article/0,9171,411434,00.html">commented</a>, “I can’t imagine a romance novel published today where the hero rapes the heroine and she falls in love with him ... I can’t think of anything in my books that any feminist would find objectionable. ... And I consider myself a feminist.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="420qaI">
Yet by 2010, the scene was being <a href="https://dearauthor.com/features/letters-of-opinion/is-there-an-irredeemable-trait/#comment-232319">discussed</a> <a href="https://dearauthor.com/features/letters-of-opinion/is-there-an-irredeemable-trait/#comment-232335">among</a> readers as an example of sexual assault and lack of consent. By 2015, readers were <a href="https://allaboutromance.com/winsome-or-loathsome-daphne-bridgerton/">dissecting the scene</a> to point out its disturbing dynamics.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fQAcgx">
That the show’s creatives included this scene while making it less broadly, but still explicitly, nonconsensual, suggests they knew it needed fixing. But it seems like they failed to see how badly they ultimately handled it. Without signaling more effectively that Daphne’s choice was just as violating for Simon as his secrecy was for Daphne, <em>Bridgerton</em> undermines its entire experiment in exploring the boundaries of consent.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CC3vNT">
Through this moment, the show also undermines its central relationship, causing us to question the whole foundation of Daphne and Simon’s affection for each other. Because <em>Bridgerton</em> doesn’t make an effort to depict Daphne’s rape of Simon as a huge issue that must be addressed for them to heal their marriage, we don’t really have much way of understanding whether their mutual trust is really fully repaired in the end. And we’re given no assurance that she won’t violate his trust the next time she decides he might be lying to her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x1LwIe">
It’s also frankly a giant gaslight; even as I write this, I’m wondering if maybe I’m wrong and that the scene <em>wasn’t</em> rape — or if, perhaps, maybe this is the one time in history where somebody gets raped and it’s just not that big a deal, so it’s just kinda okay that the show glosses over it and moves on and Simon seems totally fine afterward.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5DsmQh">
Obviously, these are horrible takeaways for a show to leave us with. The dynamics of consent are complex and often frustrating and confusing, but one thing is almost universally certain: Rape is a big deal, and it often hugely impacts and alters both the rape survivor and the rapist. For <em>Bridgerton</em> to ineffectively convey that Daphne raped Simon and then treat it like it was a minor side note to the much bigger issue of him lying to her makes it more difficult for audiences watching it to understand what consent looks like.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ueFNyN">
The fact that the rape victim here is both male and a person of color makes it even more egregious that the show is glossing over the incident. Men are often considered <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067991/">silent victims</a> of sexual assault, and Black men in particular are often <a href="https://slate.com/news-and-politics/2015/06/the-deadly-history-of-theyre-raping-our-women-racists-have-long-defended-their-worst-crimes-in-the-name-of-defending-white-womens-honor.html">made scapegoats</a> for sexual violence, which further erases the status of Black male victims of sexual assault. In this context, the show’s emphasis on Simon as the instigator of Daphne’s choice basically paints him as being responsible for his own rape. This aligns with the broader cultural gaslighting of Black men and the shifting of blame away from the white men and women who enact violence upon them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Nhbqvu">
Bridgerton has drawn its fair share of rave reviews as, among other things, “<a href="https://www.vanityfair.com/hollywood/2020/12/bridgerton-netflix-shonda-rhimes-review">delightful trash</a>.” As a huge, lifelong lover of the sorts of romance stories <em>Bridgerton</em> is adapting, what I hate most about this summation is that it implies that the ingredients of this story are a part of the inherent nature of the raunchy, racy historical romance. Not only is that a condescending attitude toward a genre that is frequently very literary and very serious, but it’s flatly wrong: Rape, especially unacknowledged rape, is by no means a feature of historical romance writing, nor was it going unaddressed and undebated back when Quinn wrote this story 20 years ago. Countless romance writers have done better than this. <em>Bridgerton</em> could and should have followed their example.
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The history of Jews, Chinese food, and Christmas, explained by a rabbi</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/jgrqFmvO6V44p5Fe3Rq4GnDtACw=/445x0:7556x5333/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/62724267/GettyImages_980080036.0.jpg"/>
<figcaption>
Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In the US, Jews have been eating American Chinese food on Christmas for over 100 years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s93koV">
For over a century, American Jews have eaten American Chinese food on Christmas. The annual feast is a holiday tradition that is likely to go on as usual this year, even in the midst of COVID-19 — albeit in the form of delivery or takeout.<strong> </strong>This pastime has evolved to a near-holy tradition, <a href="https://www.youtube.com/watch?v=BGzO1ghRKp4">parodied</a> on <em>Saturday Night Live</em>, <a href="https://www.researchgate.net/publication/249714266_New_York_Jews_and_Chinese_Food_The_Social_Construction_of_an_Ethnic_Pattern">analyzed</a> in academic papers, and <a href="https://www.youtube.com/watch?v=Tku61sKhPGo&amp;feature=youtu.be&amp;t=29s">reaffirmed</a> by Supreme Court Justice Elena Kagan.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Wiwl9">
Perhaps the foremost expert on the practice is Rabbi Joshua Eli Plaut, PhD, executive director of American Friends of Rabin Medical Center, rabbi of Metropolitan Synagogue in New York, and author of <a href="http://akosherchristmas.org"><em>A Kosher Christmas</em></a>, the premier (and only?) comprehensive study of what Jews do at Christmastime.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zU0Ue6">
I spoke to Plaut about Chinese food on Christmas, and why he used to sit on Santa Claus’s lap.
</p>
<div class="c-float-right">
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<pre><code> &lt;img alt=" " src="https://cdn.vox-cdn.com/thumbor/VlBPsAhqj7tlJ1Ga0NbabSDocCw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/13644078/51regy_EccL._SX331_BO1_204_203_200_.jpg" /&gt;</code></pre>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VCX9hc">
<strong>Both Jews and Christmas have existed for a while. When did Jews first ask, “What should we do on Christmas?” </strong><br/>It has been a question for as long as Christmas has existed, because Jews have always felt like outsiders. But how they felt specifically was really a function of their status in society. In Eastern Europe, for instance, Jews were not very assimilated. Christmas was a night of possible pogroms and violence, with so many celebrants, often drunk, going from house to house. Jews did not go to the synagogue to study. They stayed at home for physical safety reasons. If they did anything, they might play cards or chess.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U5bKG6">
In Western Europe, after the French Revolution, Jews were more assimilated. There, they had more freedom to wonder, “Do I bring a Christmas tree into my home? Do I have a holiday meal? Do I give out gifts?” The early Zionist Theodor Herzl was a secular Jew, and he had a Christmas tree in his salon. After the Chief Rabbi of Vienna came to visit, he <a href="https://forward.com/news/israel/356767/when-theodor-herzl-lit-his-christmas-tree/">wrote something in his diary</a> like, ”I hope the Rabbi doesn’t think less of me because of this. Then again, what do I care what he thinks?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xeTz1u">
<strong>Okay, so tell me when eating Chinese food on Christmas first comes into the picture. Is that a Jewish-American tradition? </strong><br/>Yes. It begins at the end of the 19th century, on the Lower East Side, where Jewish and Chinese immigrants lived in close proximity. The very first mention of American Jews eating in a Chinese restaurant dates to 1899, when the American Hebrew<em> </em>journal criticized Jews for eating at non-kosher restaurants. By 1936, a publication called the East Side Chamber News reported at least 18 Chinese tea gardens and chop suey eateries in heavily-populated Jewish neighborhoods. All of these were within close walking distance of Ratner’s, which was then the most famous Jewish dairy restaurant in Manhattan.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lF15t7">
Jews would go out for Chinese food on Sundays, when they felt left out of church lunch. It was a gradual transition from the traditional diet of Eastern Europe, to eating American Chinese food, to eating other pan-Asian cuisines, like Indian food. I like to say that, within a hundred years of arriving in New York, the average Jew was more familiar with sushi than gefilte fish.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5mDxHr">
In the last 35 years, Chinese restaurants on Christmas have really become this sort of temporary community where Jews in the United States can gather to be with friends and family. It’s a secular way to celebrate Christmas, but it’s also a time to shut out Christmas and announce your Jewish identity in a safe environment.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ULFjt4">
<strong>Was there any reason, beyond proximity, that Jews wound up eating Chinese food, as opposed to some other immigrant cuisine? </strong><br/>In terms of kosher law, a Chinese restaurant is a lot safer than an Italian restaurant. In Italian food, there is mixing of meat and dairy. A Chinese restaurant doesn’t mix meat and dairy, because Chinese cooking is virtually dairy-free.
</p>
<div class="c-float-left">
<aside id="2m9YQC">
<q>Within a hundred years of arriving in New York, the average Jew was more familiar with sushi than gefilte fish</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7xt0gD">
In Chinese-American cooking, if there is any pork [which is not a kosher food], it is usually concealed inside something, like a wonton. A lot of Jews back then — and even now — kept strict kosher inside the home but were more flexible with foods they ate at restaurants. Sociologist Gaye Tuchman <a href="https://qcpages.qc.cuny.edu/~hlevine/SAFE-TREYF.pdf">wrote about this practice</a>. She described [the plausible deniability of non-kosher ingredients] as <em>safe treyf. </em>[<em>Treyf</em> is the Yiddish word for non-kosher.] A lot of Jews considered the pork in Chinese food to be <em>safe treyf</em>, because they couldn’t see it. That made it easier to eat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QHj3Lu">
<strong>In your research for this book, did you come across anything about Chinese food and Christmas written from a Chinese-American perspective? </strong><br/>I actually found a citation from 1935, in the New York Times, about a restaurant owner named Eng Shee Chuck who brought chow mein to the Jewish Children’s Home on Christmas Day. If you were to interview Chinese restaurant owners, they’d tell you that Christmas is their biggest day of the year, outside of probably the Chinese New Year. If you want a more thorough understanding, though, you should probably go talk to some restaurant owners in Chinatown.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Z2OFTw">
<strong>Sometimes my family eats Chinese food on Christmas, but we always go to the movies. When did that become an established Jewish Christmas tradition? </strong><br/>When Jews began to settle on the Lower East Side of Manhattan between the 1880s and the 1920s, they were poor immigrants. They worked in sweatshops and lived in tenement housing. In their time off, they would go to the newly opened <a href="https://www.history.com/this-day-in-history/first-nickelodeon-opens">nickelodeons</a>. For between one cent and five cents, they could see a very early form of a movie. By 1909, there were 42 nickelodeons adjacent to the Lower East Side and 10 uptown in Jewish Harlem. Christmas was just another day off, so these early movies attracted big crowds.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BjauN9">
We know from the Yiddish press that Christmas became a popular day for the opening of new Yiddish theater productions. It was a day off from work, so what do you do? You can stay home, or you can go to the nickelodeons, or the Yiddish theater. Eventually, decades later, you could go have a meal in a Chinese restaurant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HFH8jH">
<strong>What do you usually do on Christmas? </strong><br/>For many years I was researching this book. This year, I’ll be with my family in a small town, where there are no real restaurants open. We will probably play a board game or watch Netflix.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pJ1BOy">
<strong>What did you do on Christmas growing up? </strong><br/>I never went to Chinese restaurants. We’d go skating in front of the Rockefeller Center Christmas tree, and then we’d have hot chocolate with marshmallows. I have great memories of Christmas. My mother would take me to sit on Santa Claus’s lap. When I was writing this book, I asked her, “Why did you take me — the son of a rabbi! — to sit on Santa Claus’s lap?” She said, “Everybody in America does it, so why shouldn’t we?” She knew I was secure in my Jewish identity.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Queen Justitia, Full Bloom, Indian Coral and Sentosa impress</strong> - Queen Justitia, Full Bloom, Indian Coral and Sentosa impressed when the horses were exercised here on Monday (Dec. 28).Outer sand: 600m: Rafaele (App</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs India | Pitch is getting slower, hitting one area consistently is key: Mohammed Siraj</strong> - His senior pace bowling partner Jasprit Bumrah told him that the only way to get wickets on a flat deck is to build pressure with a lot of dot balls.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs India, 2nd test | Unhappy with Paine’s dismissal, Wade calls for consistent implementation of DRS</strong> - Paine didn''t hide his disappointment over the decision while leaving the field, prompting Wade to compare it with Australia''s review of Cheteshwar Pujara on the second day's play on Sunday.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I can’t help but wonder if I am in Sydney or Wankhede, says Erin Holland on the India vs Australia series</strong> - The beauty queen-turned-cricket presenter gets candid about her career and presenting at the ongoing India vs Australia series</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Home Minister Amit Shah unveils Arun Jaitley’s statue at DDCA premises</strong> - Former India cricketer Bishan Singh Bedi had severely criticised the DDCA for choosing to install the statue of an administrator instead of an inspirational cricketer</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Injured leopard tranquilised, shifted to Bannerghatta</strong> - It was found near Devikere atop Chamundi Hills</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Centre invites farmers for talks on December 30</strong> - Committed to a logical solution, it says</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ABVP will seek refund of ‘extra’ school fees during lockdown</strong> - It will also request the Centre and respective State governments to reopen campuses of higher education in a phase-wise manner.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mamata Banerjee’s Nandigram meeting on January 7 deferred: West Bengal Minister</strong> - Mr. Mukherjee, also the State Rural Development Minister, told the reporters in Kolkata the meeting has not been cancelled.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hassan administration readying for schools’ reopening</strong> - The Hassan district administration has made preparations to reopen schools for students of Class X and II PU from January 1, 2021. The classes will be</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Hundreds of British skiers flee Swiss Verbier quarantine</strong> - More than 200 Britons flee Verbier, defying a Swiss order to remain in their hotels and chalets.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: EU ambassadors approve EU-UK trade deal</strong> - The landmark trade deal is on its way to becoming law provisionally on 1 January.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: 'Bumpy' period expected as UK adjusts to new EU rules</strong> - Ministers warn of "practical and procedural changes" when the Brexit transition period ends this week.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: EU starts mass vaccination in 'touching moment of unity'</strong> - Care home residents and health staff are first to get jabs as the 27-state bloc begins immunisations.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: EU countries begin mass vaccination</strong> - Countries across the EU received their first shipments of the Pfizer/BioNTech Covid-19 vaccines.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>2020 had its share of merorable hacks and breaches. Here are the top 10</strong> - The past 12 months teaches us that, yes, attacks <em>do</em> only get better. - <a href="https://arstechnica.com/?p=1731509">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Grubhub gig workers react angrily to change in tipping policy</strong> - Default tip amount slashed following introduction of California's new employment rules. - <a href="https://arstechnica.com/?p=1732036">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dark Archives: Come for the floating goat balls, stay for the fascinating science</strong> - Explore the macabre history of "anthropodermic bibliopegy": books bound in human skin - <a href="https://arstechnica.com/?p=1717384">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Divers recover a WWII Enigma Machine from the Baltic Sea</strong> - Divers trying to clean fishing nets come up with a bit of history. - <a href="https://arstechnica.com/?p=1731736">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The best cars, SUVs, and crossovers we drove in 2020</strong> - The Civic Type-R brought the most smiles and a pair of hybrid SUVs surprised me. - <a href="https://arstechnica.com/?p=1731665">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>An electrician comes home late....</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Wife: "Wire you insulate?"
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Electrician: "Watts it to you? I'm ohm, aren't I."
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/VERBERD"> /u/VERBERD </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/klfkdi/an_electrician_comes_home_late/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/klfkdi/an_electrician_comes_home_late/">[comments]</a></span></p></li>
<li><strong>A kid is playing video games in his room, minding his business.</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His mother walks in. "Honey, come meet my new boyfriend!"
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"I'm kind of busy right now. Can you bring him in here instead?"
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A minute or so later, her boyfriend walks in. "Hey, champ! How you doing?"
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The kid ignores him.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
"Don't like champ, huh? That's fine. How about BlueDragon72?"
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The kid turns his head quickly. "I haven't heard that name since I was ten..." He then realized. "It can't be.."
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
"Call of Duty, right? I told you I'd bang your mom."
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MudakMudakov"> /u/MudakMudakov </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/klfkzu/a_kid_is_playing_video_games_in_his_room_minding/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/klfkzu/a_kid_is_playing_video_games_in_his_room_minding/">[comments]</a></span></p></li>
<li><strong>I came home really drunk last night and my wife wasn’t happy at all. “How much have you had to drink?” she asked sternly, staring at me. “Nothing” I slurred. “Look at me!” she shouted. “It’s either me or the pub, which one is it?”</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I paused for a second while I thought and mumbled, “It’s you. I can tell by the voice.”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/moiKeshav"> /u/moiKeshav </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/klegd9/i_came_home_really_drunk_last_night_and_my_wife/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/klegd9/i_came_home_really_drunk_last_night_and_my_wife/">[comments]</a></span></p></li>
<li><strong>Why did the art thief’s van run out of gas as he drove away from the museum?</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Because he had no Monet to buy Degas to make the Van Gogh.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MarkyChoco"> /u/MarkyChoco </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kl3kik/why_did_the_art_thiefs_van_run_out_of_gas_as_he/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kl3kik/why_did_the_art_thiefs_van_run_out_of_gas_as_he/">[comments]</a></span></p></li>
<li><strong>What's made of leather and sounds like a sneeze?</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A shoe
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@ -13,9 +13,9 @@ Archive | Daily Reports
<li> <a href="#covid-19">Covid-19</a>
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<h2 id="daily-dose">Daily Dose</h2>
<ul id="daily-dose-list"><li><a href="./archive-daily-dose/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-daily-dose/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-daily-dose/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-daily-dose/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-daily-dose/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-daily-dose/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-daily-dose/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-daily-dose/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-daily-dose/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-daily-dose/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-daily-dose/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-daily-dose/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-daily-dose/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-daily-dose/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-daily-dose/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-daily-dose/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-daily-dose/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-daily-dose/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-daily-dose/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-daily-dose/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
<ul id="daily-dose-list"><li><a href="./archive-daily-dose/28 December, 2020.html">28 December, 2020</a></li><li><a href="./archive-daily-dose/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-daily-dose/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-daily-dose/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-daily-dose/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-daily-dose/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-daily-dose/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-daily-dose/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-daily-dose/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-daily-dose/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-daily-dose/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-daily-dose/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-daily-dose/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-daily-dose/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-daily-dose/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-daily-dose/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-daily-dose/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-daily-dose/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-daily-dose/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-daily-dose/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-daily-dose/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
</ul>
<h2 id="covid-19">Covid-19</h2>
<ul id="covid-19-list"><li><a href="./archive-covid-19/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-covid-19/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-covid-19/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-covid-19/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-covid-19/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-covid-19/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-covid-19/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-covid-19/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-covid-19/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-covid-19/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-covid-19/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-covid-19/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-covid-19/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-covid-19/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-covid-19/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-covid-19/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-covid-19/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-covid-19/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-covid-19/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-covid-19/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
<ul id="covid-19-list"><li><a href="./archive-covid-19/28 December, 2020.html">28 December, 2020</a></li><li><a href="./archive-covid-19/27 December, 2020.html">27 December, 2020</a></li><li><a href="./archive-covid-19/26 December, 2020.html">26 December, 2020</a></li><li><a href="./archive-covid-19/25 December, 2020.html">25 December, 2020</a></li><li><a href="./archive-covid-19/24 December, 2020.html">24 December, 2020</a></li><li><a href="./archive-covid-19/23 December, 2020.html">23 December, 2020</a></li><li><a href="./archive-covid-19/22 December, 2020.html">22 December, 2020</a></li><li><a href="./archive-covid-19/21 December, 2020.html">21 December, 2020</a></li><li><a href="./archive-covid-19/20 December, 2020.html">20 December, 2020</a></li><li><a href="./archive-covid-19/19 December, 2020.html">19 December, 2020</a></li><li><a href="./archive-covid-19/18 December, 2020.html">18 December, 2020</a></li><li><a href="./archive-covid-19/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-covid-19/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-covid-19/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-covid-19/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-covid-19/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-covid-19/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-covid-19/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-covid-19/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-covid-19/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-covid-19/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
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