navan
/
Daily-Dose
mirror of https://github.com/navanchauhan/Daily-Dose.git
1
0
Fork 0
Code Issues Projects Releases Wiki Activity

Added daily report

This commit is contained in:
Navan Chauhan 2023-05-11 12:46:12 +00:00
parent 83dacde28c
commit 5353891299
3 changed files with 731 additions and 2 deletions
Show Stats Download Patch File Download Diff File Expand all files Collapse all files

184
archive-covid-19/11 May, 2023.html Normal file
View File

@ -0,0 +1,184 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>11 May, 2023</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
ul.task-list{list-style: none;}
</style>
<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Interaction quality among children, staff and parents in German ECEC centres in the COVID-19 pandemic - Results from a longitudinal study</strong> -
<div>
Early Education and Care (ECEC) centres had implemented a variety of protective and hygiene measures during the COVID-19 pandemic. Some of these measures temporarily restricted the behaviour of pedagogical staff, children and parents, for example keeping distance from each other or wearing face masks. This may have made it difficult for staff to offer high quality interactions with a positive, sensitive attitude towards children and parents, as would be important for good pedagogical work. Long-term effects of these distance measures on the quality of daily interactions in ECEC centres are largely unexplored. Based on a panel survey among German ECEC centre leaders over a period of one and a half years, we provide a long-term assessment of the impact of specific protective measures on different levels of interactions within ECEC centres, namely on staff-child interactions, interactions of children with each other and the cooperation between staff and parents. We found child-child interaction largely unaffected by the measures, while staff-parent interaction suffered the most. Communication with parents and regular implementation of pedagogical practices have a stabilizing effect, while keeping distance from children, face masks and (pandemic-related) staff shortages worsen staff-child interactions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/63xm5/" target="_blank">Interaction quality among children, staff and parents in German ECEC centres in the COVID-19 pandemic - Results from a longitudinal study</a>
</div></li>
<li><strong>Emotional Responses to a Global Stressor: Average Patterns and Individual Differences</strong> -
<div>
Major stressors often challenge emotional well-being—increasing negative emotions and decreasing positive emotions. But how long do these emotional hits last? Prior theory and research contain conflicting views. Some research suggests that most individuals’ emotional well-being will return to, or even surpass, baseline levels relatively quickly. Others have challenged this view, arguing that this type of resilient response is uncommon. The present research provides a strong test of resilience theory by examining emotional trajectories over the first six months of the COVID-19 pandemic. In two pre-registered longitudinal studies (total N =1,147), we examined average emotional trajectories and predictors of individual differences in emotional trajectories across 13 waves of data from February through September 2020. The pandemic had immediate detrimental effects on average emotional well-being. Across the next six months, average negative emotions returned to baseline levels with the greatest improvements occurring almost immediately. Yet, positive emotions remained depleted relative to baseline levels, illustrating the limits of typical resilience. Individuals differed substantially around these average emotional trajectories and these individual differences were predicted by socio-demographic characteristics and stressor exposure. We discuss theoretical implications of these findings that we hope will contribute to more nuanced approaches to studying, understanding, and improving emotional well-being following major stressors.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/g3jr7/" target="_blank">Emotional Responses to a Global Stressor: Average Patterns and Individual Differences</a>
</div></li>
<li><strong>Healthcare resource utilisation and costs of hospitalisation and primary care among adults with COVID-19 in England: a population-based cohort study</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives To quantify healthcare resource utilisation (HCRU) and costs to the National Health Service (NHS) associated with acute COVID-19 in adults in England. Design Population-based retrospective cohort study, using Clinical Practice Research Datalink (CPRD) Aurum primary care electronic medical records linked when available to Hospital Episode Statistics (HES) secondary care administrative data. Setting Patients registered to primary care practices in England. Population 1,706,368 adults with a positive SARS-CoV-2 PCR or antigen test from August 2020 to January 2022 were included; 13,105 within the hospitalised cohort indexed between August 2020 and March 2021, and 1,693,263 within the primary care cohort indexed between August 2020 and January 2022. Main outcome measures Primary and secondary care HCRU and associated costs during the acute phase of COVID-19 (≤4 weeks following positive test), stratified by age group, risk of severe COVID-19 and immunocompromised status. Results Among the hospitalised cohort, average total length of stay, as well as in critical care wards, was longer in older adults. Median healthcare cost per hospitalisation was higher in those aged 75 - 84 (£8,942) and ≥85 years (£8,835) than in those aged &lt;50 years (£7,703). Whilst few (6.0%) patients in critical care required mechanical ventilation, its use was higher in older adults (50 - 74 years: 8.3%; &lt;50 years: 4.3%). HCRU and associated costs were often greater in those at higher risk of severe COVID-19 when compared to the overall cohort, although minimal differences in HCRU were found across the three different high-risk definitions implemented. Among the primary care cohort, GP or nurse consultations were more frequent among older adults and the immunocompromised. Conclusions COVID-19 related hospitalisations in older adults, particularly critical care admissions, were the primary drivers of high resource use of COVID-19 in England. These findings may inform health policy decisions and resource allocation in the prevention and management of COVID-19.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.05.10.23289557v1" target="_blank">Healthcare resource utilisation and costs of hospitalisation and primary care among adults with COVID-19 in England: a population-based cohort study</a>
</div></li>
<li><strong>Angry, sad, or scared? Within-valence mapping of emotion words to facial and body cues in 2- to 4-year-old children</strong> -
<div>
The acquisition of emotion words is critical to children’s socio-emotional development. Previous studies report that children acquire emotion words gradually during ages 3–5 and beyond. The majority of this work, however, has used demanding tasks for young children (e.g., asking children to label emotion-related facial configurations) and has predominantly relied on facial configurations. Here we designed a child-friendly, word-comprehension task incorporating both facial configurations and body language. In two preregistered online experiments, we asked two to four-year-olds (N = 96) to connect emotion words—happy, sad, angry, and scared—to either facial configurations (Experiment 1) or combined facial and body cues (Experiment 2). We found relatively early competence in understanding emotion words, especially those of the same-valence. All age groups, including 2-year-olds, successfully linked emotion words to corresponding facial configurations (Experiment 1). Experiment 2 replicated this pattern and further showed that children performed equally well (though not substantially better) when given additional body cues. Parental reports of children’s exposure to and use of masks during the COVID-19 pandemic did not correlate with children’s performance in either experiment. Even before children can produce emotion words in an adult-like manner, they possess at least a partial understanding of those words and can map them to emotion cues within valence domains.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/ka3ed/" target="_blank">Angry, sad, or scared? Within-valence mapping of emotion words to facial and body cues in 2- to 4-year-old children</a>
</div></li>
<li><strong>Stability and change in young children’s linguistic experience during the COVID-19 pandemic: insight from a citizen-science sample in the United States</strong> -
<div>
Early in the COVID-19 pandemic, extensive lockdowns interrupted daily routines, including childcare. We asked whether these interruptions, and the inevitable changes in the people with whom children spent their waking hours, caused changes in the languages that children heard. We retrospectively queried parents of young children (0-4 years) in the US about childcare arrangements and exposure to English and non-English languages at four timepoints from February 2020 to September 2021. Despite discontinuity in childcare arrangements, we found that children’s exposure to English vs. other languages remained relatively stable. We also identified demographic variables (child age at pandemic onset, parental proficiency in a non-English language) that consistently predicted exposure to non-English languages. Thus, multilingually-exposed children in this population did not appear to significantly gain or lose the opportunity to hear non-English languages overall. These results provide insight into the experiences of this unique cohort and inform our understanding of how language development can be shaped by complex environmental systems.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/8anb9/" target="_blank">Stability and change in young children’s linguistic experience during the COVID-19 pandemic: insight from a citizen-science sample in the United States</a>
</div></li>
<li><strong>Surveillance strategies for the detection of new SARS-CoV-2 variants across epidemiological contexts</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Rapid identification of new SARS-CoV-2 variants is a critical component of the public health response to the COVID-19 pandemic. However, we lack a quantitative framework to assess the expected performance of sampling strategies in varying epidemic contexts. To address this gap, we used a multi-patch stochastic model of SARS-CoV-2 spread in New York City to evaluate the impact of the volume of testing and sequencing, geographic representativeness of sampling, location and timing of variant emergence, and relative variant transmissibility on the time to first detection of a new variant. The strategy of targeted sampling of likely emergence locations offered the most improvement in detection speed. Increasing sequencing capacity reduced detection time more than increasing testing volumes. The relative transmissibility of the new variant and the epidemic context of variant emergence also influenced detection times, showing that individual surveillance strategies can result in a wide range of detection outcomes, depending on the underlying dynamics of the circulating variants. These findings help contextualize the design, interpretation, and trade-offs of genomic surveillance strategies.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.05.09.23289744v1" target="_blank">Surveillance strategies for the detection of new SARS-CoV-2 variants across epidemiological contexts</a>
</div></li>
<li><strong>Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Several XBB subvariants such as XBB.1.5, XBB.1.9, XBB.1.16 and XBB.2.3 co-circulate in Singapore. Despite the different viral properties of XBB.1.16 as compared to other XBB subvariants, comparison on their severity is limited. In this study, we investigate the outcomes of hospitalisation and severe COVID-19 infection in individuals infected with different XBB subvariants, adjusted for potential confounders such as age and vaccination history. Overall, our preliminary analysis showed no difference in the severity of different XBB variants.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.05.04.23289510v1" target="_blank">Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore</a>
</div></li>
<li><strong>Tracking the prevalence and emergence of SARS CoV2 variants of concern using a regional genomic surveillance program</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
SARS-CoV-2 molecular testing coupled with whole genome sequencing is instrumental for real-time genomic surveillance. Genomic surveillance is critical for monitoring the spread of variants of concern (VOC) as well as novel variant discovery. Since the beginning of the pandemic millions of SARS-CoV-2 genomes have been deposited into public sequence databases. This is the result of efforts of both national and regional diagnostic laboratories. Here we describe the results of SARS-CoV-2 genomic surveillance from February 2021 to June 2022 at a metropolitan hospital in the USA. We demonstrate that consistent daily sampling is sufficient to track the regional prevalence and emergence of VOC. Similar sampling efforts should be considered a viable option for local SARS-CoV-2 genomic surveillance at other regional laboratories.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.05.08.23289687v1" target="_blank">Tracking the prevalence and emergence of SARS CoV2 variants of concern using a regional genomic surveillance program</a>
</div></li>
<li><strong>The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Early in the COVID-19 pandemic, peak viral loads coincided with symptom onset. We hypothesized that in a highly immune population, symptom onset might occur earlier in infection, coinciding with lower viral loads. Methods: We assessed SARS-CoV-2 and influenza A viral loads relative to symptom duration in recently-tested adults. Symptomatic participants ≥16y presenting to testing sites in Georgia (4/2022- 4/2023; Omicron variant predominant) provided symptom duration. Nasal swab samples were tested by the Xpert Xpress SARS-CoV-2/Flu/RSV assay and Ct values recorded. Nucleoprotein concentrations in SARS-CoV-2 PCR-positive samples were measured by Single Molecule Array. To estimate hypothetical antigen rapid diagnostic test (Ag RDT) sensitivity on each day after symptom onset, percentages of individuals with Ct value ≤30 or ≤25 were calculated. Results: Of 621 SARS-CoV-2 PCR-positive individuals (64.1% women, median 40.9y), 556/621 (89.5%) had a history of vaccination, natural infection, or both. By both Ct value and antigen concentration measurements, median viral loads rose from the day of symptom onset and peaked on the fourth day. Ag RDT sensitivity estimates were 35.7-71.4% on the first day, 63.9-78.7% on the third day, and 78.6-90.6% on the fourth day of symptoms. In 74 influenza A PCR-positive individuals (55.4% women; median 35.0y), median influenza viral loads peaked on the second day of symptoms. Conclusions: In a highly immune adult population, median SARS-CoV-2 viral loads peaked on the fourth day of symptoms. Influenza A viral loads peaked soon after symptom onset. These findings have implications for ongoing use of Ag RDTs for COVID-19 and influenza.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.05.09.23289735v1" target="_blank">The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs</a>
</div></li>
<li><strong>SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure</strong> -
<div>
Patients with pre-existing heart failure are at a particularly high risk of morbidity and mortality resulting from SARS-CoV-2 infection. Direct acute cardiac injury or cytokine storms have been proposed to contribute to depressed cardiac function. However, the pathogenic mechanisms underlying the increased vulnerability to heart failure in SARS-CoV-2 infected patients are still largely unknown. Here, we found that the senescent outcome of SARS-CoV-2 spike protein (SARS-2-S)-induced syncytia exacerbated heart failure progression. We first demonstrated that syncytium formation in cells expressing SARS-2-S delivered by DNA plasmid or LNP-mRNA exhibits a senescence-like phenotype. Extracellular vesicles containing SARS-2-S (S-EVs) also confer a potent ability to form senescent syncytia without de novo synthesis of SARS-2-S. Mechanistically, SARS-2-S syncytia provoke the formation of functional MAVS aggregates, which regulate the senescence fate of SARS-2-S syncytia by TNF. We further demonstrate that senescent SARS-2-S syncytia exhibit shrinked morphology, leading to the activation of WNK1 and impaired cardiac metabolism. In pre-existing heart failure mice, the WNK1 inhibitor WNK463, anti-syncytial drug niclosamide, and senolytic dasatinib protect the heart from exacerbated heart failure triggered by pseudovirus expressing SARS-2-S (SARS-2-Spp). Signs of senescent multinucleated cells are identified in ascending aorta from SARS-CoV-2 omicron variant-infected patient. Our findings thus suggest a potential mechanism for COVID-19-mediated cardiac pathology and recommend the application of WNK1 inhibitor for therapy.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.10.10.511541v2" target="_blank">SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure</a>
</div></li>
<li><strong>A Solution to the Kermack and McKendrick Integro-Differential Equations</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In this manuscript, we derive a closed form solution to the full Kermack and McKendrick integro-differential equations (Kermack and McKendrick 1927) which we call the KMES. The KMES can be cast in the form of a step function response to the input of new infections; and that response is the time series of the total infections. We demonstrate the veracity of the KMES using independent data from the Covid 19 pandemic and derive many previously unknown and useful analytical expressions for diagnosing and managing an epidemic. These include new expressions for the viral load, the final size, the effective reproduction number, and the time to the peak in infections. Since the publication of the Kermack and McKendrick seminal paper (1927), thousands of authors have utilized the Susceptible, Infected, and Recovered (SIR) approximations; expressions which are putatively derived from the integro-differential equations, to model epidemic dynamics. Implicit in the use of the SIR approximation are the beliefs that there is no closed form solution to the more complex integro-differential equations, that the approximation adequately reproduces the dynamics of the integro-differential equations, and that herd immunity always exists. However, as we explicate in this manuscript, the KMES demonstrates that the SIR models are not adequate representations of the integro-differential equations, and herd immunity is not guaranteed. Our conclusion is that the KMES obsoletes the need for the SIR approximations; and provides a new level of understanding of epidemic dynamics.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.04.28.22274442v2" target="_blank">A Solution to the Kermack and McKendrick Integro-Differential Equations</a>
</div></li>
<li><strong>COVID-19-related conspiracy beliefs and their relationship with perceived stress and pre-existing conspiracy beliefs in a Prolific Academic sample: A replication and extension of Georgiou et al. (2020)</strong> -
<div>
The authors reanalyzed the data and conducted a close replication of a study by Georgiou et al. (2020), who found amongst 660 (reported in abstract) or 640 (reported in participant section) participants that 1) COVID-19 related conspiracy theory beliefs were strongly related to broader conspiracy theory beliefs, that 2) COVID-19 related conspiracy beliefs were higher in those with lower levels of education, and that 3) COVID-19 related conspiracy beliefs were positively (although weakly) correlated with more negative attitudes towards different individual items measuring the government’s response. Finally, Georgiou et al. (2020) found that 4) COVID-19 beliefs were unrelated to self-reported stress. Reanalyzing their data and adjusting the analytical framework, the authors only found that an average of attitudes towards the appropriateness of the government response towards the pandemic was negatively related to conspiracy beliefs in general (not just COVID-19). In the present replication and extension study, random forest analyses show that attitude towards government responses (like the original study), stress (unlike the original study), and attachment avoidance towards the partner (unlike the original study) are the most important predictors of conspiracy beliefs. However, the explained variance of the whole random forest model (3.5-7.5%) was low and model fit of the presently and widely used conspiracy belief inventories was poor. Measurement error is a likely explanation for the differences between the original and replication study and independent development-validation studies therefore need to be conducted to better measure conspiracy beliefs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/t62s7/" target="_blank">COVID-19-related conspiracy beliefs and their relationship with perceived stress and pre-existing conspiracy beliefs in a Prolific Academic sample: A replication and extension of Georgiou et al. (2020)</a>
</div></li>
<li><strong>An agent-based modeling approach for lung fibrosis in response to COVID-19</strong> -
<div>
The severity of the COVID-19 pandemic has created an emerging need to investigate the long-term effects of infection on patients. Many individuals are at risk of suffering pulmonary fibrosis due to the pathogenesis of lung injury and impairment in the healing mechanism. Fibroblasts are the central mediators of extracellular matrix (ECM) deposition during tissue regeneration, regulated by anti-inflammatory cytokines including transforming growth factor beta (TGF-{beta}). The TGF-{beta}-dependent accumulation of fibroblasts at the damaged site and excess fibrillar collagen deposition lead to fibrosis. We developed an open-source, multiscale tissue simulator to investigate the role of TGF-{beta} sources in the progression of lung fibrosis after SARS-CoV-2 exposure, intracellular viral replication, infection of epithelial cells, and host immune response. Using the model, we predicted the dynamics of fibroblasts, TGF-{beta}, and collagen deposition for 15 days post-infection in virtual lung tissue. Our results showed variation in collagen area fractions between 2% and 40% depending on the spatial behavior of the sources (stationary or mobile), the rate of activation of TGF-{beta}, and the duration of TGF-{beta} sources. We identified M2 macrophages as primary contributors to higher collagen area fraction. Our simulation results also predicted fibrotic outcomes even with lower collagen area fraction when spatially-localized latent TGF-{beta} sources were active for longer times. Our results showed that partial removal of TGF-{beta} sources changed the fibrotic patterns; in the presence of persistent TGF-{beta} sources, partial removal of TGF-{beta} from the ECM significantly increased collagen area fraction due to maintenance of chemotactic gradients driving fibroblast movement. The computational findings are consistent with independent experimental and clinical observations of collagen area fractions and cell population dynamics not used in developing the model. These critical insights into the activity of TGF-{beta} sources may find applications in the current clinical trials targeting TGF-{beta} for the resolution of lung fibrosis.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.10.03.510677v2" target="_blank">An agent-based modeling approach for lung fibrosis in response to COVID-19</a>
</div></li>
<li><strong>Sibling Relationships and Parental Interventions to Sibling Bullying During Covid-19: A Qualitative Comparison of British and Turkish Families of Autistic Adolescents</strong> -
<div>
Background and aims: Despite its high potential for affecting sibling relationships, few studies have explored the impact of the Covid-19 pandemic on this important family dynamic. Of these, the reported evidence has been inconsistent across cultures and lacks cross-cultural comparability. For the first time, we investigated cross-cultural variability in the impact of Covid-19, and the restrictions associated with it, on sibling relationships of autistic adolescents from a Western (United Kingdom) and non-Western (Turkey) country. We also explored how British and Turkish parents intervene in negative sibling interactions – i.e., sibling bullying –when witnessed. Methods: Parents of 164 British and 96 Turkish autistic adolescents, aged 9-20 years, were asked how they perceived the effects of Covid-19 on their children’s sibling relationships, and how they were most likely to react to instances of sibling bullying. Free response data from parents were analysed using qualitative content analysis. Results: Our findings indicated more cross-cultural similarities than differences between British and Turkish families. The majority of both British and Turkish parents indicated that Covid-19 worsened sibling relationships between their autistic and non-autistic children. An overwhelming majority of British and Turkish parents also said that they would step in directly when witnessing sibling bullying. Despite the high volume of cross-cultural similarities generally, we also found some cross-cultural differences, for instance in relation to the most common negative impact of Covid-19 on sibling relationships and the most preferred parental responses to sibling bullying. Conclusions and implication: Implications and suggestions are discussed in more detail, drawing on the Etic approach to cross-cultural psychology.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/nqez3/" target="_blank">Sibling Relationships and Parental Interventions to Sibling Bullying During Covid-19: A Qualitative Comparison of British and Turkish Families of Autistic Adolescents</a>
</div></li>
<li><strong>Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen</strong> -
<div>
Effective therapies are needed to combat emerging viruses. Seventeen candidates that rescue cells from SARS-CoV-2-induced lethality and target diverse functions emerged in a screen of 4,413 compounds. Among the hits was lapatinib, an approved inhibitor of the ErbB family of receptor tyrosine kinases. Lapatinib and other pan-ErbB inhibitors suppress replication of SARS-CoV-2 and unrelated viruses with a high barrier to resistance. ErbB4, but not lapatinib’s cancer targets ErbB1 and ErbB2, is required for SARS-CoV-2 entry and encephalitic alphavirus infection and is a molecular target mediating lapatinib’s antiviral effect. In human lung organoids, lapatinib protects from SARS-CoV-2-induced activation of pathways implicated in non-infectious acute lung injury and fibrosis downstream of ErbBs (p38-MAPK, MEK/ERK, and AKT/mTOR), pro-inflammatory cytokine production, and epithelial barrier injury. These findings reveal regulation of viral infection, inflammation, and lung injury via ErbBs and propose approved candidates to counteract these effects with implications for pandemic coronaviruses and unrelated viruses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.15.444128v3" target="_blank">Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Standard of Care Combined With Glucocorticoid in Elderly People With Mild or Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Glucocorticoid<br/><b>Sponsor</b>:   Huashan Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Arginine Replacement Therapy in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Arginine Hydrochloride<br/><b>Sponsor</b>:   Emory University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effectiveness of a Second COVID-19 Vaccine Booster in Chinese Adults</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Intramuscularly administered Ad5-nCoV vaccine;   Biological: Aerosolized Ad5-nCoV;   Biological: DelNS1-2019-nCoV-RBD-OPT1;   Biological: SYS6006<br/><b>Sponsor</b>:   Jiangsu Province Centers for Disease Control and Prevention<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Long COVID-19 Syndrome Lifestyle Intervention Study</strong> - <b>Condition</b>:   Long COVID-19 Syndrome<br/><b>Intervention</b>:   Dietary Supplement: Low carbohydrate diet intervention<br/><b>Sponsor</b>:   University of Southern California<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in Norway</strong> - <b>Conditions</b>:   Post COVID-19 Condition, Unspecified;   SARS-CoV2 Infection;   COVID-19<br/><b>Interventions</b>:   Drug: Nirmatrelvir/ritonavir;   Drug: Placebo<br/><b>Sponsors</b>:   Haukeland University Hospital;   University of Bergen<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Working Towards Empowered Community-driven Approaches to Increase Vaccination and Preventive Care Engagement</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Other: mHealth Outreach;   Other: Care Coordination<br/><b>Sponsors</b>:   University of California, San Diego;   San Ysidro Health Center<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety, Tolerability and Immunogenicity of Alveavax-v1.2, a BA.2/Omicron-optimized, DNA Vaccine for COVID-19 Prevention</strong> - <b>Condition</b>:   Sars-CoV-2 Infection<br/><b>Interventions</b>:   Drug: Alveavax-v1.2;   Drug: Janssen Ad26.COV2.S<br/><b>Sponsor</b>:   Alvea Holdings, LLC<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effectiveness of Modified Diaphragmatic Training for Gastroesophageal Reflux Disease Post Covid-19</strong> - <b>Conditions</b>:   GERD;   Post COVID-19 Condition;   Diaphragm Issues<br/><b>Interventions</b>:   Other: modified diaphragmatic training;   Other: standard diaphragmatic training<br/><b>Sponsor</b>:   Indonesia University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Role of Anthropometric Indices and Vit-D Supplementation on BioNTech, Pfizer Vaccine Side Effect and Immunoglobulin G Response Against SARS-CoV-2 in Individuals Infected With COVID-19; A Randomized Control Trial</strong> - <b>Condition</b>:   Role of Anthropometric Indices and Vit-D Supplementation on BioNTech, Pfizer Vaccine Side Effect and IgG Response Against SARS-CoV-2<br/><b>Intervention</b>:   Combination Product: Vitamin-D<br/><b>Sponsor</b>:   Sulaimany Polytechnic university<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Vaccination Detoxification in LDL-C</strong> - <b>Conditions</b>:   COVID-19 Stress Syndrome;   COVID-19 Vaccine Adverse Reaction;   COVID-19-Associated Thromboembolism;   COVID-19 Post-Intensive Care Syndrome;   COVID-19-Associated Stroke;   COVID-19 Respiratory Infection<br/><b>Intervention</b>:   Combination Product: Atorvastatin Calcium Tablets<br/><b>Sponsor</b>:   Yang I. Pachankis<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial</strong> - <b>Conditions</b>:   Post-Acute COVID-19 Syndrome;   Dysautonomia<br/><b>Interventions</b>:   Procedure: Rehabilitation;   Procedure: Standard of Care<br/><b>Sponsors</b>:   Evangelismos Hospital;   National and Kapodistrian University of Athens;   LONG COVID GREECE;   414 Military Hospital of Special Diseases<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exercise for Health in Patients With Post-acute Sequelae of COVID-19</strong> - <b>Condition</b>:   Long COVID<br/><b>Intervention</b>:   Other: Rehabilitation program<br/><b>Sponsors</b>:   Campus docent Sant Joan de Déu-Universitat de Barcelona;   Hospital de Mataró;   University of Barcelona<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Digital Multimodal Rehabilitation for People With Post-acute COVID-19 Syndrome.</strong> - <b>Condition</b>:   Post-COVID Syndrome<br/><b>Interventions</b>:   Behavioral: RehabCovid_Telematic;   Behavioral: RehabCovid_ImmersiveVR;   Behavioral: Control_Condition<br/><b>Sponsors</b>:   Consorci Sanitari de Terrassa;   University of Barcelona;   Universitat de Girona;   Unitat Assistencial i Preventiva de l’Esport- Centre d’Alt rendiment;   Politecnic University of Catalonia;   Corporación Fisiogestión<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Drug-Drug Interaction Potential of Single and Multiple Doses of ALG-097558</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: ALG-097558;   Drug: Placebo;   Drug: Midazolam;   Drug: Itraconazole;   Drug: Carbamazepine;   Drug: ALG-097558 in solution formulation;   Drug: ALG-097558 in tablet formulation<br/><b>Sponsor</b>:   Aligos Therapeutics<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome</strong> - <b>Conditions</b>:   Post-COVID-19 Syndrome;   Post-COVID Syndrome;   Post COVID-19 Condition<br/><b>Interventions</b>:   Device: Immunoadsorption;   Device: Sham-apheresis<br/><b>Sponsor</b>:   University Medical Center Mainz<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nature-inspired catalytic asymmetric rearrangement of cyclopropylcarbinyl cation</strong> - In nature, cyclopropylcarbinyl cation is often involved in cationic cascade reactions catalyzed by natural enzymes to produce a great number of structurally diverse natural substances. However, mimicking this natural process with artificial organic catalysts remains a daunting challenge in synthetic chemistry. We report a small molecule-catalyzed asymmetric rearrangement of cyclopropylcarbinyl cations, leading to a series of chiral homoallylic sulfide products with good to excellent yields and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Designer DNA NanoGripper</strong> - DNA has shown great biocompatibility, programmable mechanical properties, and structural addressability at the nanometer scale, making it a versatile material for building high precision nanorobotics for biomedical applications. Herein, we present design principle, synthesis, and characterization of a DNA nanorobotic hand, called the “NanoGripper”, that contains a palm and four bendable fingers as inspired by human hands, bird claws, and bacteriophages evolved in nature. Each NanoGripper finger…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Transcriptome Analysis Reveals Organ-Specific Effects of 2-Deoxyglucose Treatment in Healthy Mice</strong> - CONCLUSIONS: These findings suggest that 2DG has a systemic impact that varies across organs, potentially affecting multiple pathways and functions. The study provides insights into the potential therapeutic benefits of 2DG across different diseases and highlights the importance of understanding its systemic effects for future research and clinical applications.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection</strong> - Glycoprotein 90K, encoded by the interferon-stimulated gene LGALS3BP, displays broad antiviral activity. It reduces HIV-1 infectivity by interfering with Env maturation and virion incorporation, and increases survival of Influenza A virus-infected mice via antiviral innate immune signaling. Its antiviral potential in SARS-CoV-2 infection remains largely unknown. Here, we analyzed the expression of 90K/LGALS3BP in 44 hospitalized COVID-19 patients at multiple levels. We quantified 90K protein…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice</strong> - The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has raised concerns about reduced vaccine effectiveness and the increased risk of infection, and while repeated homologous booster shots are recommended for elderly and immunocompromised individuals, they cannot completely protect against breakthrough infections. In our previous study, we assessed the immunogenicity of an adenovirus-based vaccine expressing SARS-CoV-2 S1 (Ad5.S1) in mice, which induced robust…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Frontline Worker Safety in the Age of COVID-19: A Global Perspective</strong> - The third annual Health Watch USAsm webinar conference assembled 16 speakers from 4 continents who shared information regarding frontline worker safety in the age of COVID-19. The U.S. Bureau of Labor Statistics reported a nearly 4000% increase in workplace illness in 2020 compared with 2019. It is estimated that 2% of the U.S. workforce is not working because of long COVID. In addition, the impact is growing with each surge. After the acute illness, patients are often described as recovered,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reparixin improves survival in critically ill and transplant patients: A meta-analysis</strong> - CONCLUSIONS: The findings of this meta-analysis indicate that reparixin, an anti-inflammatory drug, improved survival in critically ill or transplant patients (including both COVID-19 and non-COVID-19 patients) without increasing the risk of infection.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bioinformatics approach to analyse COVID-19 biomarkers accountable for generation of intracranial aneurysm in COVID-19 patients</strong> - COVID-19 became a health emergency on January 30, 2020. SARS-CoV-2 is the causative agent of the coronavirus disease known as COVID-19 and can develop cardiometabolic and neurological disorders. Intracranial aneurysm (IA) is considered the most significant reason for hemorrhagic stroke,and it accounts for approximately 85% of all subarachnoid hemorrhages (SAH). Retinoid signaling abnormalities may explain COVID-19’s pathogenesis with inhibition of AEH2, from which COVID-19 infection may enhance…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Adjunctive therapy with lipid-lowering agents in COVID-19: a systematic review and meta-analysis of randomized controlled trials</strong> - CONCLUSION: Although some observational studies found improved outcomes in patients using lipid-lowering agents, our study found no benefit in adding statins, fenofibrate, or nicotinamide to COVID-19 treatment. On the other hand, PCSK9 inhibitors can be a good candidate for further assessment. Finally, there are major limitations in the use of omega-3 supplements in treating COVID-19 and more trials are warranted to evaluate this efficacy.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice</strong> - CONCLUSIONS: Our study demonstrates that envelope protein could directly induce depression-like behaviors, dysosmia, and obvious neuroinflammation in CNS. TLR2 mediated depression-like behaviors and dysosmia induced by envelope protein, which could serve as a promising therapeutic target for neurological manifestation in COVID-19 patients.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eight-Month Follow-up After the Third Dose of BNT162b2 Vaccine in Healthcare Workers: The Question of a Fourth Dose</strong> - CONCLUSION: For HCWs who had coronavirus disease 2019 infection after completing a third vaccination, a sufficient antibody response was maintained until eight months after the third dose. The recommendation of the fourth dose may not be prioritized in subjects with hybrid immunity.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Polyphenylene carboxymethylene (PPCM), the active component of the topical contraceptive Yaso-GEL, exhibits potent antimicrobial activity against <em>Neisseria gonorrhoeae</em> in preclinical studies</strong> - CONCLUSIONS: Yaso-GEL containing the API PPCM showed significant activity against N. gonorrhoeae in vitro and in vivo in a female mouse model. These data support further development of Yaso-GEL as an inexpensive, non-hormonal and non-systemic product with both contraceptive and antimicrobial activity against gonorrhea and other common sexually transmitted infections (STIs). Such multipurpose prevention technology products are needed by women in all economic, social and cultural circumstances to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of Potential TMPRSS2 Inhibitors for COVID-19 Treatment in Chinese Medicine by Computational Approaches and Surface Plasmon Resonance Technology</strong> - CONCLUSIONS: Specific active compounds including narirutin, saikosaponin B1, and rutin in CM recipes potentially target and inhibit TMPS2, probably exerting a therapeutic effect on COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comparison of antibody responses following natural infection with Severe Acute Respiratory Syndrome Coronavirus 2 or receipt of CoronaVac or ChAdOx1 (AZD1222) vaccination in Chiang Mai, Thailand</strong> - CONCLUSIONS: ChAdOx1 vaccine may provide superior immunogenicity than CoronaVac and natural infection.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In-Silico Approaches for the Screening and Discovery of Broad-Spectrum Marine Natural Product Antiviral Agents Against Coronaviruses</strong> - The urgent need for SARS-CoV-2 controls has led to a reassessment of approaches to identify and develop natural product inhibitors of zoonotic, highly virulent, and rapidly emerging viruses. There are yet no clinically approved broad-spectrum antivirals available for beta-coronaviruses. Discovery pipelines for pan-virus medications against a broad range of betacoronaviruses are therefore a priority. A variety of marine natural product (MNP) small molecules have shown inhibitory activity against…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<script>AOS.init();</script></body></html>

545
archive-daily-dose/11 May, 2023.html Normal file
View File

@ -0,0 +1,545 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>11 May, 2023</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
ul.task-list{list-style: none;}
</style>
<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tony Hsieh and the Emptiness of the Tech-Mogul Myth</strong> - A new biography of the Zappos executive depicts him as a narcissist and an addict who tossed around half-baked ideas and rarely saw them through. - <a href="https://www.newyorker.com/news/our-columnists/tony-hsieh-and-the-emptiness-of-the-tech-mogul-myth">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Joe Biden’s Economic Ratings Could Rebound with Voters</strong> - Strong job growth and falling inflation may still pay off in 2024. - <a href="https://www.newyorker.com/news/our-columnists/how-joe-bidens-economic-ratings-could-rebound-with-voters">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Enduring Panic About Cow Mutilations</strong> - Aliens, the government, or unspecified shadowy forces—another round of “mutes” incites familiar fears. - <a href="https://www.newyorker.com/news/letter-from-the-southwest/the-enduring-panic-about-cow-mutilations">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Supreme Court Ruling the Fossil-Fuel Industry Doesn’t Like</strong> - Communities can now sue in state courts for compensation for the costs of climate change—something oil companies have fought against for years. - <a href="https://www.newyorker.com/news/daily-comment/a-supreme-court-ruling-the-fossil-fuel-industry-doesnt-like">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Vindication of E. Jean Carroll</strong> - In response to a writer’s accusation of sexual assault, nine jurors in Manhattan finally held Donald Trump accountable. - <a href="https://www.newyorker.com/news/our-local-correspondents/the-vindication-of-e-jean-carroll">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>AI is moving fast. Washington is not.</strong> -
<figure>
<img alt="President Biden looking at a quantum computer." src="https://cdn.vox-cdn.com/thumbor/rjY6W1LKOrnZWaR1eE_UOWpwmc4=/0x0:3747x2810/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72269442/GettyImages_1243772656.0.jpg"/>
<figcaption>
The Biden administration has a lot of cutting-edge technology on its plate, from quantum computers like the one above to generative AI. | Mandel Ngan/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Is DC doomed to make the same mistakes with AI that it made with social media?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xojnbw">
Joe Biden has used ChatGPT, and he’s <a href="https://www.axios.com/2023/05/04/biden-ai-chatgpt-white-house">reportedly</a> “fascinated” by it. That makes him a lot like most of us, who have marveled over <a href="https://www.vox.com/recode/2023/3/4/23624033/openai-bing-bard-microsoft-generative-ai-explained">generative AI’s</a> <a href="https://www.vox.com/recode/2023/1/5/23539055/generative-ai-chatgpt-stable-diffusion-lensa-dall-e">ability</a> to create words, images, audio, and video from simple prompts, since the technology became widely available to the general public in 2022. But Biden is also different from everyone because he’s the president of the United States, with the authority and the responsibility for making sure that technological advances are also safe.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4x4bPs">
His administration is now trying to figure out how to do that. Congress might be, too. Europe <a href="https://www.reuters.com/technology/eu-lawmakers-committee-reaches-deal-artificial-intelligence-act-2023-04-27/">definitely is</a>, and at a comparatively rapid pace. While the US government wants to at least appear to be considering and mitigating any potential harms from generative AI, how it will do that remains to be seen. Especially given Washington’s spotty track record when it comes to reining in Big Tech.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aQnG6o">
The latest entrant to the generative AI arms race is Google, which has <a href="https://www.vox.com/recode/2023/2/7/23590069/bing-openai-microsoft-google-bard">lagged behind</a> rival Microsoft with its generative AI-powered chatbot and search. Google <a href="https://www.vox.com/e/23482918">announced</a><strong> </strong>on Wednesday that it would be integrating its AI offerings into just about all of its major products, including Google Docs. That includes Google Search, the tool that most of America uses all the time to navigate the internet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FsLad7">
AI isn’t new, and neither are attempts to regulate it. But generative AI is a big leap forward, and so are the problems or dangers it could unleash on a world that isn’t ready for it. Those include disinformation spread by convincing deepfakes and misinformation spread by chatbots that “<a href="https://www.nytimes.com/2023/05/01/business/ai-chatbots-hallucination.html">hallucinate</a>,” or make up facts and information. <a href="https://www.businessinsider.com/ai-art-generators-dalle-stable-diffusion-racial-gender-bias-ceo-2023-3">Inherent biases</a> could cause people to be discriminated against. Millions of people might suddenly be put out of work, while intellectual property and privacy rights are bound to be threatened by the technology’s appetite for data to train on. And the computing power needed to support AI technology makes it prohibitively expensive to develop and run, leaving all but a few rich and powerful companies to rule the market.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E6FiP6">
We’ve been largely relying on these big technology companies to regulate themselves. That strategy hasn’t worked so well in the past because businesses only voluntarily play things safe when it’s in their own best interests to do so. But the government has a chance to get ahead of things now, rather than try to deal with problems after they come up and are far harder to solve. The government is also historically slow or unable to take on tech companies, between administrations with limited powers, courts that tend to rule in businesses’ best interests, and a Congress that <a href="https://www.axios.com/2020/12/14/congress-legislation-covid-19-2020">can’t seem to pass any laws</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5vIXba">
“Congress is behind the eight ball. If our incapacity was a problem with traditional internet platforms like Facebook, the issue is ten times as urgent with AI,” Sen. Michael Bennet (D-CO) told Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G6FZFZ">
With Google, Microsoft, and a host of other tech companies now rushing their AI services out to as many of their products as possible, it might be even more urgent than that.
</p>
<h3 id="faNhoY">
The White House can move faster than Congress — and it is
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F7dF6j">
The Biden administration has recently stepped up its ongoing efforts to ensure that AI is responsible and safe. On May 4, after several members of the Biden administration met with the CEOs of companies on the forefront of generative AI — Google, Anthropic, Microsoft, and OpenAI — the White House <a href="https://www.whitehouse.gov/briefing-room/statements-releases/2023/05/04/fact-sheet-biden-harris-administration-announces-new-actions-to-promote-responsible-ai-innovation-that-protects-americans-rights-and-safety/">announced several actions</a> meant to “protect people’s rights and safety” while promoting “responsible AI innovation.” Those include funding for several <a href="https://new.nsf.gov/news/nsf-announces-7-new-national-artificial">new research institutes</a>, a “public evaluation” of some existing generative AI systems <a href="https://www.wired.com/story/joe-biden-hackers-chatgpt-ai-chatbots/">at DEF CON</a>, a security conference in Las Vegas, this August, and having the Office of Management and Budget provide policy guidance for how the federal government uses AI systems.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lNtHZy">
This builds on the administration’s previous actions, which have ramped up alongside generative AI. Last fall’s <a href="https://www.vox.com/future-perfect/23387228/ai-bill-of-rights-white-house-artificial-intelligence-bias">AI Bill of Rights</a> established a set of protections Americans should have from AI systems. According to the document, the public is entitled to safe and effective systems; it deserves protections from algorithmic discrimination and data privacy invasions; and it should be told when AI is being used and given the ability to opt out. And while these sound all well and good, they’re just recommendations, to which compliance is voluntary.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k9mE0y">
To a certain extent, federal agencies are already empowered to create regulations that may apply to generative AI products and enforce consequences for companies that violate them. The Biden administration has directed agencies to protect Americans from harmful AI according to their own purview. For example, the Equal Employment Opportunity Commission <a href="https://www.eeoc.gov/ai">tackles issues</a> related to employment and discrimination, and the <a href="https://www.copyright.gov/ai/">Copyright Office</a> and the <a href="https://www.federalregister.gov/documents/2023/02/14/2023-03066/request-for-comments-regarding-artificial-intelligence-and-inventorship">Patent and Trademark Office</a> are looking into if and how to apply their intellectual property rules to generative AI.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TjR3CG">
The National Telecommunications and Information Administration is <a href="https://www.federalregister.gov/documents/2023/04/13/2023-07776/ai-accountability-policy-request-for-comment">currently asking</a> for comments on accountability policies that would ensure AI tools are “legal, effective, ethical, safe, and otherwise trustworthy.” These, the agency says, will include “adequate internal or external enforcement to provide for accountability.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GT0osY">
And there are things agencies already have the power to do. The heads of the EEOC, Consumer Financial Protection Bureau, Department of Justice’s Civil Rights Division, and Federal Trade Commission recently issued a <a href="https://www.ftc.gov/system/files/ftc_gov/pdf/EEOC-CRT-FTC-CFPB-AI-Joint-Statement%28final%29.pdf">joint statement</a> declaring that they have the authority to regulate AI within their respective spaces and that they will enforce those rules when needed. The AI Now Institute, which is run by two former AI advisers to the FTC, recently <a href="https://www.vox.com/future-perfect/2023/4/12/23677917/ai-artificial-intelligence-regulation-big-tech-microsoft-openai">put out a report</a> that, among other things, made the case for how competition policy can be used to keep AI companies in check.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T7oHzy">
“This flavor of artificial intelligence that involves massive amounts of data and massive amounts of computational power to process it has structural dependencies on resources that only a few firms have access to,” said Sarah Myers West, managing director of AI Now Institute. “Competition law is central to regulating generative AI and AI more broadly.”
</p>
<figure class="e-image">
<img alt="FTC chair Lina Khan." src="https://cdn.vox-cdn.com/thumbor/Q7brnaygM2lp4g0eiVPfSxgAhzQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24648628/GettyImages_1249642645.jpg"/> <cite>Al Drago/Bloomberg via Getty Images</cite>
<figcaption>
FTC chair Lina Khan is ready and willing to use her agency’s tools to protect consumers and competition from generative AI.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mmzjYp">
West noted that Microsoft has already done a few questionable things to disadvantage competitors, like reportedly <a href="https://www.bloomberg.com/news/articles/2023-03-25/microsoft-threatens-to-restrict-bing-data-from-rival-ai-search-tools">forbidding companies</a> from using its Bing search index to power their own chatbots. That’s the kind of thing the FTC or the antitrust arm of the Department of Justice could potentially act on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LTNfxu">
Meanwhile, FTC chair Lina Khan has indicated that she is ready and willing to use the agency’s competition and consumer protection mandates to keep AI companies in check. She recently <a href="https://www.nytimes.com/2023/05/03/opinion/ai-lina-khan-ftc-technology.html">wrote a New York Times op-ed</a> saying that the consequences of unchecked growth of Web 2.0 should serve as an impetus for agencies to act now on AI. The FTC, she said, will be vigilant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iQKG4c">
“Although these tools are novel, they are not exempt from existing rules, and the FTC will vigorously enforce the laws we are charged with administering, even in this new market,” Khan wrote.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1Bs1aT">
The problem with the administration’s efforts here is that administrations change, and the next one may not have the same vision for AI regulations. The Trump administration, which predated the meteoric rise of generative AI, was open to some agency oversight, but it also <a href="https://www.vox.com/recode/2020/1/8/21056809/artificial-intelligence-new-ai-principles-white-house">didn’t want</a> those agencies to “needlessly hamper AI innovation and growth” — especially not in the face of <a href="https://www.nytimes.com/2017/07/20/business/china-artificial-intelligence.html">China’s 2017</a> vow to become the world leader by 2030. If Republicans win the White House in 2024, we’ll likely see a more hands-off, business-friendly approach to AI regulations. And even if not, agencies are still limited by what laws give them the authority to oversee.
</p>
<h3 id="LaJ96L">
The self-regulating option that always fails
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ONuPyy">
Many federal lawmakers have learned that Big Tech and social media companies can operate recklessly when guardrails are self-imposed. But those lessons haven’t resulted in much by way of actual laws, even after the consequences of not having them became obvious and even when both parties say they want them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I9E3yF">
Before generative AI was widely released, AI was still a concern for the government. There were fears, for example, about algorithmic accountability and facial recognition. The House has had an AI Caucus <a href="https://www.nextgov.com/emerging-tech/2017/06/congressional-ai-caucus-wants-separate-fact-fiction/139064/">since 2017</a>, and the Senate’s respective caucus dates <a href="https://www.heinrich.senate.gov/newsroom/press-releases/heinrich-portman-launch-bipartisan-artificial-intelligence-caucus">back to 2019</a>. Federal, state, and even <a href="https://www.vox.com/recode/2019/5/14/18623897/san-francisco-facial-recognition-ban-explained">local</a> governments have been considering those aspects for years. Illinois has had a facial recognition law on its books since 2008, which says businesses must get users’ permission to collect their biometric information. Meta is <a href="https://www.vox.com/recode/2020/7/23/21335806/facebook-settlement-illinois-facial-recognition-photo-tagging">one of</a> several companies that has run afoul of this law over the years, and had to pay big fines as a result.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KhdCgN">
There’s plenty of reason to believe that tech companies won’t adequately regulate themselves when it comes to AI. While they often make it a point to say that they value safety, want to develop responsible AI platforms, and employ responsible AI teams, those concerns are secondary to their business interests. Responsible AI researchers <a href="https://www.vox.com/recode/22465301/google-ethical-ai-timnit-gebru-research-alex-hanna-jeff-dean-marian-croak">risk getting fired</a> if they speak out negatively about the products they’re investigating, or <a href="https://www.theverge.com/2023/3/13/23638823/microsoft-ethics-society-team-responsible-ai-layoffs">laid off</a> if their employer needs to reduce its headcount. Google held off on releasing its AI systems to the public for years, fearing that it hadn’t yet considered all of the problems those could cause. But when Microsoft and OpenAI made their offerings widely available early this year, Google <a href="https://www.nytimes.com/2023/01/20/technology/google-chatgpt-artificial-intelligence.html">aggressively accelerated</a> the development and release of its AI products to compete. Its chatbot, Bard, came out <a href="https://www.vox.com/technology/2023/3/22/23651093/google-bard-ai-chatbot-microsoft-chat-gpt-generative">six weeks</a> after Microsoft’s.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zec8y0">
On the same day that Biden met with several AI CEOs in May, Microsoft <a href="https://blogs.microsoft.com/blog/2023/05/04/announcing-the-next-wave-of-ai-innovation-with-microsoft-bing-and-edge/">announced</a> it was expanding its new Bing and Edge, which incorporate OpenAI’s tools. They’re now more widely available and have a few new features. And while Microsoft says it’s committed to a “responsible approach” to AI, Bing’s chatbot <a href="https://www.washingtonpost.com/technology/2023/04/05/chatgpt-lies/">still has issues</a> with hallucinating. Microsoft is forging ahead and monetizing the results of its investment in OpenAI, waving off concerns by saying that Bing is still in preview and mistakes are bound to happen.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SFnI35">
A week after that, Google made its announcement about integrating AI into pretty much everything, making sure to <a href="https://blog.google/technology/ai/google-responsible-ai-io-2023/">highlight</a> some of the tools it has developed to ensure that Google’s AI products are responsible (according to Google’s parameters).
</p>
<h3 id="fDGUyg">
Congress has yet to come together on a plan for AI
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s1noPJ">
Finally, Congress can always pass laws that would directly address generative AI. It’s far from certain that it will. Few bills that deal with online dangers — from <a href="https://www.vox.com/recode/22189727/2020-pandemic-ruined-digital-privacy">privacy</a> to <a href="https://www.vox.com/recode/2020/7/3/21307873/facial-recognition-ban-law-enforcement-apple-google-facebook">facial recognition</a> to AI — get passed. Big Tech-specific <a href="https://www.vox.com/recode/22529779/antitrust-bills-house-big-tech">antitrust bills</a> largely languished last Congress. But several members of Congress have been outspoken about the need for or desire to create laws to deal with AI. Rep. Ted Lieu (D-CA) <a href="https://lieu.house.gov/media-center/press-releases/rep-lieu-introduces-first-federal-legislation-ever-written-artificial">asked ChatGPT</a> to write a bill that directs Congress to “focus on AI” to ensure that it’s a safe and ethical technology. He has also <a href="https://www.nytimes.com/2023/01/23/opinion/ted-lieu-ai-chatgpt-congress.html">written</a> that AI “freaks me out.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="loFICI">
Bennet, the Colorado senator, <a href="https://www.bennet.senate.gov/public/index.cfm/2023/4/bennet-introduces-legislation-to-stand-up-an-ai-task-force-to-ensure-responsible-use-of-the-technology-by-the-federal-government">recently introduced</a> the Assuring Safe, Secure, Ethical, and Stable Systems for AI (ASSESS) Act, which would ensure that the federal government uses AI in an ethical way.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MkrNq5">
“As the government begins to use AI, we need to make sure we do so in a way that’s consistent with our civil liberties, civil rights, and privacy rights,” Bennet said.
</p>
<figure class="e-image">
<img alt="A Google executive on stage at the I/O developers conference." src="https://cdn.vox-cdn.com/thumbor/J06aCwsO44CCfI5u8_zpnhI0Vv0=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24648651/GettyImages_1253654037.jpg"/> <cite>Josh Edelson/AFP via Getty Images</cite>
<figcaption>
Google’s James Manyika announces the company’s AI offerings, being sure to stress how responsible they are, as per Google’s definition of responsible.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZaKpIu">
Bennet would also like to see a new agency dedicated to regulating Big Tech, including its use of generative AI. He <a href="https://www.bennet.senate.gov/public/index.cfm/2022/5/bennet-introduces-landmark-legislation-to-establish-federal-commission-to-oversee-digital-platforms">introduced a bill</a> last session that would create such an agency, the Digital Platform Commission Act. But getting Congress to go for standing up a new agency is a tall order when so many lawmakers bristle at the idea of the existing agencies exerting the powers they already have.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LDadxH">
Congress has a well-deserved reputation for being very much behind the times, both in understanding what new technologies are and in passing legislation that deals with new and unique harms they may cause. They’ve also been reluctant to make laws that could inhibit these companies’ growth or give any kind of advantage to another country, especially to China (which, by the way, is <a href="https://www.axios.com/2023/05/08/china-ai-regulation-race">developing its own AI regulations</a>).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="54pehq">
Daren Orzechowski, a lawyer who often represents tech companies, said it’s important for regulations not to be so heavy-handed that they stop companies from developing technologies that may well improve society.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="peO5UK">
“The more prudent approach might be to set some guardrails and some guidelines versus being overly restrictive,” he said. “Because if we are overly restrictive, we may lose out on some really good innovation that can help in a lot of ways.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Wh6Ml0">
That said, it does at least appear that some legislation will be coming out of Congress in the coming months. Sen. Chuck Schumer (D-NY) <a href="https://www.democrats.senate.gov/newsroom/press-releases/schumer-launches-major-effort-to-get-ahead-of-artificial-intelligence">announced in April</a> that he has created a “framework” for laws that deal with AI. While his position as Senate majority leader means he has control over which bills get a floor vote, the Democrats don’t have the majority needed to pass them without at least some Republicans jumping on board. And getting it past the Republican-controlled House is another story altogether. It’s also not known how much support Schumer’s plan will get within his own party; <a href="https://www.politico.com/news/2023/05/04/congresss-scramble-build-ai-agenda-00095135">reportedly</a>, very few members of Congress knew about this plan at all.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WFi3Iy">
“Look at how privacy laws have progressed on the federal level,” Orzechowski said. “I think that’s probably an indicator that it’s not likely something will be passed to touch on this area when they haven’t been able to get something passed with respect to privacy.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="434Yko">
Real guardrails for generative AI may not come from the US at all. The European Union appears to have taken the lead on regulating the technology. The <a href="https://digital-strategy.ec.europa.eu/en/policies/european-approach-artificial-intelligence">AI Act</a>, which has been in the works for years, would classify AI technology by risk levels, with corresponding rules according to those risks. The European Commission recently added a new section for generative AI, including copyright rules. ChatGPT was also <a href="https://www.bbc.com/news/technology-65431914">temporarily banned</a> in Italy over possible breaches of the EU’s General Data Protection Regulation, illustrating how some of the EU’s existing regulations for online services can be applied to new technologies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QfY715">
It all just shows how other countries are already willing and able to deal with AI’s potential for harm, while the US scrambles to figure out what, if anything, it will do.
</p></li>
<li><strong>The blatant discrimination of Ron DeSantis’s anti-China housing law</strong> -
<figure>
<img alt="Ron DeSantis speaks into a handheld microphone, gesturing with his other hand. He’s wearing a blue suit and white shirt, and stands in front of a tall blue backdrop showing the state of Florida." src="https://cdn.vox-cdn.com/thumbor/JWg9Aj1dxY536wB_KKW4sdecPdw=/654x0:5879x3919/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72269380/1251988408.0.jpg"/>
<figcaption>
Florida Gov. Ron DeSantis speaks to a crowd at the North Charleston Coliseum on April 19, 2023, in North Charleston, South Carolina. | Sean Rayford/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
DeSantis wants to beef up his “tough on China” cred. The result is a racist law.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZHtUlB">
This week, <a href="https://www.vox.com/politics/23622719/ron-desantis-2024-presidential-opportunism">Florida Gov. Ron DeSantis</a> signed <a href="https://www.theguardian.com/us-news/2023/may/09/ron-desantis-bills-ban-chinese-citizens-buying-land-florida#:~:text=Governor%20Ron%20DeSantis%20of%20Florida,buying%20land%20in%20the%20state">disturbing legislation</a> that could fuel racial profiling of <a href="https://thehill.com/homenews/state-watch/3994861-desantis-signs-bill-that-will-ban-chinese-citizens-from-buying-land-in-florida/">Chinese immigrants in the state</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="534zHh">
<a href="https://www.flsenate.gov/Session/Bill/2023/264/BillText/er/PDF">The bill,</a> which bars many Chinese citizens from buying property in Florida, is the latest in an ongoing state and federal effort from Republican lawmakers to emphasize that they are <a href="https://www.vox.com/22558949/china-violence-asian-americans">“tough on China”</a> as geopolitical and economic tensions have grown between the two countries. Activists, however, fear that it codifies and emboldens racial profiling in the state, making it harder for Chinese immigrants and Asian Americans to buy homes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JmfmKM">
The Florida policy is theoretically intended to combat the influence of the Chinese Communist Party on US affairs, according to DeSantis. However, its broad scope and focus on Chinese people who have no ties to the government has fueled concerns about who will actually be impacted by it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="N6iQMT">
“The reality will be that any seller, when they see a Chinese name … will think, ‘Too much trouble,’ and they’ll refuse to sell,” says Echo King, a Chinese American attorney based in Orlando, Florida, who has helped organize opposition to the legislation as part of the Florida Asian American Justice Alliance. “My community, lots of people are scared.”
</p>
<aside id="u5qJdk">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rNHezO">
The policy allows some Chinese citizens — those with non-tourist visas — to purchase land, though they aren’t allowed to buy more than two acres, and can only do so at least five miles from military sites. That provision is still extremely restrictive, given the number of places in Florida that could be classified as military sites, activists note. Another provision in the bill bars citizens of Russia, Iran, North Korea, Cuba, Venezuela, and Syria from purchasing farmland that’s within 10 miles of specific sites. It’s set to go into effect on July 1.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fpEwNI">
The legislation underscores how broad, xenophobic policies can result as a product of the anti-China rhetoric that has grown in the last few years. There’s much that the US should hold the Chinese government accountable for, including horrific human rights violations such as the mass internment of the Uyghur population. But the framing often used by lawmakers regarding issues like economic competition creates an “us versus them” mentality that, historically, has spurred discrimination and racial profiling of Asian Americans.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q586M1">
The spike in anti-China sentiment and policies is reminiscent of past instances when foreign policy concerns were conflated with the domestic treatment of Asian Americans. During World War II, 120,000 Japanese Americans were sent to internment camps because the US was at war with Japan, for example.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5cUCNV">
“It is frankly what we’ve seen throughout history, that when there are issues involving a foreign nation, there’s a backlash against the Asian American community in the United States,” John Yang, the executive director of Asian Americans Advancing Justice, <a href="https://www.vox.com/2022/6/19/23172702/vincent-chin-murder-fortieth-anniversary">previously told Vox</a>.
</p>
<h3 id="GADW72">
The threat of xenophobic policies
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qybpUr">
DeSantis isn’t the only lawmaker backing anti-China policies. Republicans — and some Democrats, like Senate Majority Leader Chuck Schumer — have made proposals countering China a major focus, <a href="https://www.nbcnews.com/politics/congress/senate-democrats-launch-renewed-effort-counter-china-rcna82703">as they’ve sought to bolster the United States’s ability</a> to compete in manufacturing and other sectors. That’s not to say that all these proposals take the same broadly discriminatory approach as the Florida law, but that there is bipartisan interest in curbing the Chinese government’s economic and political power.
</p>
<aside id="EAMZs2">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kD63Fh">
<a href="https://www.texastribune.org/2023/04/03/chinese-americans-texas-rights/">In Texas</a>, there’s similarly been an outcry in Asian American and immigrant communities about a bill working its way through the state legislature that would be comparable to Florida’s new law, and bar many Chinese citizens from owning property. King says she and others plan to file a lawsuit against the Florida law.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NVTiHz">
“You can target foreign governments, you can target [the] foreign Chinese Communist Party, but you have to separate that from the individuals that are already in this country and protected by the Constitution,” Hugh Li, president of the Austin Chinese-American Network, <a href="https://www.texastribune.org/2023/04/03/chinese-americans-texas-rights/">previously told the Texas Tribune</a>. “This is our land too. This is our home too.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Um67sg">
Republican lawmakers and some Democrats have responded to criticism of the policies by saying they only want to target land purchases by the Chinese government. They argue allowing those aligned with the Chinese government to purchase land creates a national security risk if they’re able to establish a presence near sensitive sites like naval bases, or agricultural areas involved with the US food supply. However, the bills are so broadly written that many individuals with no affiliation to the government are likely to be affected by them as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YByggL">
No barriers to land ownership have passed at the federal level, though there has been discussion about bills focused on <a href="https://flood.house.gov/media/press-releases/congressman-flood-and-house-republicans-push-end-chinese-communist-partys-land">limiting purchases of farmland</a>. House Republicans have also set up a specific select committee to scrutinize China, trafficking in xenophobic rhetoric as tensions with the country have grown. In one instance, <a href="https://thehill.com/homenews/house/3875852-texas-republican-doubles-down-on-attack-on-judy-chus-heritage/">Texas Rep. Lance Gooden</a> questioned Chinese American Rep. Judy Chu’s loyalty to the United States, a statement that received widespread pushback from both Democrats and Republicans and that Chu has described as “outrageous” and “racist.”
</p>
<aside id="DfUKSn">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EXHWuB">
Outside of Congress, efforts like the Trump-era China Initiative by the Justice Department — which has <a href="https://www.npr.org/2022/02/23/1082593735/justice-department-china-initiative">been ended</a> — have also led to the racial profiling of Chinese American scientists, including some who were <a href="https://www.science.org/content/article/controversial-u-s-china-initiative-gets-new-name-tighter-focus-industrial-espionage">wrongly prosecuted for alleged espionage</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jlz8Xi">
In the past, there have been many cases in which inflammatory rhetoric led to violence and punitive policies, particularly when the US has had economic or military conflict with other countries, as is currently the case with China. The parallels with those instances are part of why there’s been such a strong reaction to the Florida and Texas bills, and why language like Gooden’s has caused such alarm.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h07uQu">
After the 9/11 terrorist attacks, South Asian Americans and Muslim Americans were racially profiled domestically as the US aimed to address terrorism in the Middle East. During the <a href="https://www.pbs.org/wgbh/americanexperience/features/mccarthy-numbed-with-fear-chinese-americans/">Korean</a> and <a href="https://www.hklaw.com/en/insights/media-entities/2021/06/a-brief-history-of-discrimination-against-asian-and-pacific-islander">Vietnam</a> Wars, there were violent attacks on Chinatowns and Asian American people in the US. <a href="https://www.vox.com/2022/6/19/23172702/vincent-chin-murder-fortieth-anniversary">In 1982,</a> 27-year-old Chinese American Vincent Chin was killed by two white auto workers who blamed him for the industry’s increasing competition from Japan. And during the Covid-19 pandemic, thousands of Asian Americans were scapegoated as Trump and other lawmakers <a href="https://www.vox.com/2020/6/23/21300332/trump-coronavirus-racism-asian-americans">used racist rhetoric</a> to emphasize the virus’s origins in China.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UeEUTb">
The Asian Pacific American Caucus in Congress as well as <a href="https://peoplesaction.org/wp-content/uploads/2021/06/JIG_AntiAsianRacismReport_2021_0608.pdf">progressive foreign policy organization Justice is Global</a> has <a href="https://capac-chu.house.gov/press-release/capac-leaders-issue-guidance-anti-china-messaging-and-anti-asian-violence">released guidance</a> with recommendations of how to discuss competition and other concerns with China, while being cognizant of the impact on Asian Americans. One key takeaway is focusing any attacks on the Chinese government, rather than levying them against Chinese people as a whole.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Cn84F">
“Any rhetoric and any policy that treats every single person from China as a potential agent of the government is both going to lead to these sorts of racist policies and also completely unjustified,” says Tobita Chow, the executive director of Justice is Global. “That is a myth that’s grounded in racist tropes and isn’t going to serve the purposes of US national security.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QCWnpr">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FG7z7b">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dz1dDF">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HUd17z">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mupC3M">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iJG8mt">
</p></li>
<li><strong>A giant patch of seaweed is growing to record sizes in the Atlantic. Sorry, Florida.</strong> -
<figure>
<img alt="A white sand beach with umbrellas faces a line of turquoise water with dark bobs of seaweed, seen from above." src="https://cdn.vox-cdn.com/thumbor/MovgbFsOaBh4r0bMqNxk31B7y8M=/423x0:3800x2533/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72269273/GettyImages_1482260796.0.jpg"/>
<figcaption>
Dark patches of Sargassum seaweed can be seen in the water in Miami Beach, Florida, in March. | Jeffrey Greenberg/Universal Images Group via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It’s a stinky ecological wonder.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zJnWAi">
Florida is known for many things: amusement parks, warm weather, <a href="https://www.vox.com/23021971/florida-gay-trans-lgbtq-laws">anti-LGBTQ politics</a>, retirees, manatees.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dZKzeM">
Oh, and increasingly, seaweed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LxBVIo">
This spring, large blobs of a Sargassum, a kind of algae, have been washing ashore in southeast Florida. It looks bad and smells worse: As the golden algae decompose, they release hydrogen sulfide, a gas that reeks of rotten eggs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TDDmXy">
Florida and other regions of the Caribbean are used to influxes of Sargassum in the spring and summer, but the invasion appears to be getting worse on average, year over year.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/QH03igjjylrMLXiiNefrSI6gTrU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24647230/Apr_2023_GASB.png"/> <cite>Courtesy of Brian Barnes/<a class="ql-link" href="https://optics.marine.usf.edu/projects/SaWS.html" target="_blank">Sargassum Watch System</a>/University of South Florida</cite>
<figcaption>
The Great Atlantic Sargassum Belt in April 2023, as detected by satellite imagery. Darker red corresponds to denser quantities of seaweed; density decreases from yellow to green to blue.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5mV5tl">
The source of this seaweed — which looks a bit like a brambly plant — is an enormous patch of Sargassum in the open ocean, known as the Great Atlantic Sargassum Belt. It stretches more than 5,000 miles from West Africa to the Caribbean. And the amount of algae it contains has <a href="https://optics.marine.usf.edu/projects/SaWS.html">exploded</a> in recent years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wyRIBD">
In March, satellite data detected 13 million tons of Sargassum in the belt, a <a href="https://optics.marine.usf.edu/projects/SaWS/pdf/Sargassum_outlook_2023_bulletin3_USF.pdf">monthly record</a>, according to data from the University of South Florida, and April saw <a href="https://optics.marine.usf.edu/projects/SaWS/pdf/Sargassum_outlook_2023_bulletin4_USF.pdf">similarly large amounts</a> of the algae. Some scientists speculate, based on recent trends, that seaweed blooms in spring and summer may continue to grow in the years to come.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IUx7AA">
It’s this growing belt that inundates beaches in Florida and the Caribbean with seaweed. Ocean currents push the patch westward, and mats of algae break off and wash ashore.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/hkSaZmbP6Ck8Qo6-MjLuSj8M_WU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24647244/GettyImages_1480566133.jpg"/> <cite>Federica Grassi/Getty Images</cite>
<figcaption>
Mounds of Sargassum piled up on the beach in Akumal in Mexico’s Yucatan Peninsula on March 31, 2023.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Hcxbyw">
All this seaweed can be a problem for tourism, fishing, and other coastal industries, especially on Caribbean islands like Puerto Rico and Trinidad and Tobago. In large amounts, hydrogen sulfide gas can also irritate the eyes and throat, although this is mostly a concern in enclosed spaces.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fiP06m">
But there’s a flip side: Sargassum is an essential component of marine ecosystems in the open ocean, and it may even help fight climate change.
</p>
<h3 id="56sDmM">
A golden rainforest in the open ocean
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9Fbq7R">
The stretch of ocean between Florida and West Africa may seem pretty desolate — there are few islands and a lot of open sea. Yet this region boasts a tremendous diversity of life, from young fish and crabs to turtles and seabirds, some of which are found nowhere else on Earth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IJbMI7">
Sargassum is the linchpin of this open-ocean ecosystem. The seaweed floats in tangled, island-like mats that are concentrated in two main areas of the North Atlantic: the Great Atlantic Sargassum Belt and, just north of it, the Sargasso Sea.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/KaS5H_5AgrFaGLGHOuYvVWzMbak=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24647347/fmars_08_768470_g001.jpeg"/> <cite>José Luis López Miranda et al./<a class="ql-link" href="https://www.frontiersin.org/articles/10.3389/fmars.2021.768470/full" target="_blank"><em>Frontiers in Marine Science</em></a></cite>
<figcaption>
A map showing the Sargasso Sea and the Great Atlantic Sargassum Belt.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uMjhkU">
The expanse of Sargassum here <a href="https://mpa.highseasalliance.org/sargasso-sea">has been compared</a> to a rainforest because it provides shelter and food for a variety of animals.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i3JFlY">
“It’s an essential habitat for so many species,” Brian Barnes, an oceanographer at the University of South Florida, said of Sargassum. “There are so many different organisms that have evolved to live in these random aggregations in the middle of the ocean.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HpHXTT">
The Sargasso Sea is among the planet’s most interesting ecosystems. It’s the only sea with no land borders; it’s bounded instead by ocean currents that form a soft barrier between the sea and the rest of the ocean.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3X9UWA">
The sea is a nursery for jacks, tuna, mackerel, and other fish that people eat. It’s home to <a href="http://www.sargassoseacommission.org/index.php?option=com_content&amp;view=article&amp;id=106">a number of species</a> found only in Sargassum ecosystems, such as the Sargassum shrimp and Sargassum frogfish (which <a href="https://ocean.si.edu/ocean-life/fish/world-adrift-life-sargassum-slideshow">both look</a> a whole lot like algae). The Sargasso Sea is also the <a href="https://mpa.highseasalliance.org/sargasso-sea">only known</a> place on Earth where American and European eels spawn.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/5OURv2hFyyTyFIHGCYRbGrZ9hw0=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24647259/GettyImages_1221739909.jpg"/> <cite>Aleksei Permiakov/Getty Images</cite>
<figcaption>
A Sargassum frogfish.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2d6fqA">
Sargassum is a nuisance when it washes ashore, and it can <a href="https://coral.org/en/blog/the-stench-of-sargassum-season-how-seaweed-is-threatening-mesoamerica/#:~:text=Without%20clean%20ocean%20water%2C%20there,the%20habits%20of%20other%20animals.">smother coral reefs</a> and <a href="https://www.frontiersin.org/files/Articles/699664/fmars-08-699664-HTML/image_m/fmars-08-699664-t002.jpg">harm other coastal ecosystems</a>. Yet beached seaweed also harbors critters that provide food for shorebirds, and it can fertilize plants growing along the beach, helping reduce coastal erosion, David Die, a marine scientist at the University of Miami, <a href="https://voxmedia.stories.usechorus.com/compose/14bc869c-531d-4ff8-a1d9-d89e96c8c78b#:~:text=https%3A//www.cnn.com/videos/world/2023/05/08/exp%2Dseaweed%2Dblob%2Ddavid%2Ddie%2Dintv%2D050802aseg2%2Dcnni%2Dworld.cnn">told CNN</a>.
</p>
<h3 id="NHqbpt">
The giant Sargassum patch is growing. Why?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BrwfUf">
There have likely always been floating chunks of seaweed between the Caribbean and West Africa. But in 2011, something changed and the amount of Sargassum exploded. The scale was so massive that even satellite images could see it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JJSydp">
With few exceptions, the abundance of Sargassum in this region — which became known as the Great Atlantic Sargassum Belt — has been rising ever since. In the last six years, the amount of seaweed in the belt <a href="https://optics.marine.usf.edu/projects/SaWS.html">doubled</a> compared to the previous six years, according to the University of South Florida, which tracks the blooms.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/_dk1Qk9gp29K3G68wf3pO5c4aXo=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24647290/365_83_f3.jpeg"/> <cite><a class="ql-link" href="https://www.science.org/doi/10.1126/science.aaw7912" target="_blank">Mengqiu Wang et al./<em>Science</em></a></cite>
<figcaption>
The amount of Sargassum in the Great Atlantic Sargassum belt has been steadily increasing since it first exploded in 2011.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vI8Qeg">
What’s causing this constant growth — and the 2011 tipping point — is still something of a mystery, though humans are likely partially to blame.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zni3W9">
One explanation is tied to pollution. An enormous amount of fertilizer runoff and other chemicals enter rivers like the Amazon that flow into the Atlantic, where they can fuel algae blooms. Deforestation also <a href="https://www.sciencedirect.com/science/article/abs/pii/S2213305415300126">increases the amount of nutrient-rich sediment</a> that flows into rivers, and that sediment feeds algae, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k1lHMS">
<a href="https://phys.org/news/2023-05-experts-discuss-facts-fiction-florida.html">Some researchers</a> also suspect that rising ocean temperatures, as well as changes in wind patterns, may be behind the recent blooms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="suOcMP">
Off the West Coast of Africa, cold, nutrient-rich water rises from the deep ocean, which feeds Sargassum in the eastern portion of the belt. Changes in wind patterns, possibly linked to climate change, can strengthen or weaken this coldwater upwelling. Under the right conditions, winds can also push the seaweed patch closer to the mouths of rivers, including the Amazon and Orinoco in South America, stoking the bloom even more.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/wpXREPWN6SynuwNwX15pZucGB8M=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24647268/GettyImages_1474705629.jpg"/> <cite>Heather Paul/Getty Images</cite>
<figcaption>
A mat of Sargassum seaweed floating in waters near Cozumel, Mexico.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Okf5LQ">
A combination of these forces likely triggered the 2011 boom, and they continue to cause algae to balloon. Yet it’s still not clear how climate change will shape ocean currents and wind patterns — and what that means for the Sargassum belt.
</p>
<h3 id="IdZAwZ">
Florida will be fine (at least in terms of seaweed)
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xPGxX8">
Frightening media reports refer to a “<a href="https://www.nytimes.com/2023/03/14/us/seaweed-blob-florida-mexico.html">giant blob</a>” of seaweed barreling toward Florida. That’s not quite right. The Great Atlantic Sargassum Belt is not one big blob; it’s a vast stretch of ocean spotted with clumps of algae. And it’s not like the whole thing is about to ram into Florida.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JwqJv9">
Plus, Florida doesn’t get the brunt of the algae that does wash ashore, Barnes said. Caribbean islands, like Turks and Caicos, Trinidad and Tobago, and Hispaniola are the places that tend to get inundated, he said, and this can cause serious issues.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qDgbtH">
Last year, there was so much of the seaweed in the US Virgin Islands that the territory’s governor <a href="https://www.vi.gov/governor-bryan-declares-state-of-emergency-to-mitigate-impact-of-sargassum-inundation-on-territory/">declared</a> a state of emergency after Sargassum clogged a desalinization plant on St. Croix. Problems like these are real, and likely to get worse if the belt keeps growing.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/ynBPDLyVgpi47j9M0PK6-TnFQwo=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24647256/GettyImages_1161853047.jpg"/> <cite>Alejandro Cegarra/Washington Post via Getty Images</cite>
<figcaption>
Sargassum seaweed in the coastal waters in Cancun, Mexico, on July 17, 2019.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MXii60">
Yet there are also some benefits to this abundance, beyond the value of Sargassum for animals and commercial fish in the open ocean. Like kelp and other seaweeds, Sargassum sucks up carbon dioxide, a greenhouse gas, as it grows. And at least some of that carbon is stored for long periods, meaning it doesn’t decay and send carbon back into the atmosphere.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aO9vHo">
“Carbon sequestration can be a positive outlook of this phenomena,” authors of a <a href="https://www.frontiersin.org/articles/10.3389/fmars.2021.699664/full">2021 study</a> said of the growing abundance of Sargassum in the Atlantic. This is especially important, the authors added, considering that many other marine environments that remove carbon, including mangrove forests and seagrass beds, have been destroyed. (Seaweed left on the shore, however, can decay and release carbon back into the atmosphere.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QYbPlT">
Entrepreneurs are also trying to turn Sargassum into useful products, such as <a href="https://www.sanpedrosun.com/community-and-society/2019/05/27/sargassum-solution-mexican-entrepreneur-says-turn-it-into-building-material-on-ambergris-caye/">bricks</a>, <a href="https://mexicodailypost.com/2022/08/24/quintana-roo-based-company-is-transforming-sargassum-into-organic-fertilizer/">fertilizers</a>, and food additives.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BveoxF">
That’s not to say we should all be celebrating Sargassum. It can, however, be worth recognizing that this giant bloom is not some evil, uncontrollable force threatening to destroy our vacations. It is a phenomenon humans help fuel and on which many marine creatures rely.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NHRC notice to sports ministry over ‘absence’ of panel in federations to address sexual harassment charges</strong> - The notices come at a time when several wrestlers are protesting at Jantar Mantar.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fighton, Shabelle, Mojito, Fast Pace and Snowpiercer impress</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2023 | India call-up is not far away for Rinku Singh: Harbhajan Singh</strong> - With 337 runs at a strike rate of 151 in 11 games, the diminutive left-hander Rinku Singh has made a name for himself as a finisher</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Diksha, Amandeep and Tvesa to lead the Indian challenge in Jabra Ladies Open in France</strong> - Five Indian golf players to take part in Jabra Ladies Open, as part of the Ladies European Tour. Diksha Dagar, Amandeep Drall and Tvesa Malik are set to lead the Indian challenge.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inter beats AC Milan 2-0 in 1st leg of derby Champions League semifinal</strong> - Edin Džeko and Henrikh Mkhitaryan scored two goals in three minutes to put Inter firmly in command in the Champions League semifinal fixture against rivals AC Milan</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protest march over surgeon’s murder in Kollam</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indian Maritime University announces admissions</strong> - Around 1,000 seats are available on the six campuses in Chennai, Kochi, Kolkata, Nerul-Navi Mumbai, Sewri-Mumbai and Visakhapatnam and 17 maritime training institutes are affiliated to the university</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NHRC notice to sports ministry over ‘absence’ of panel in federations to address sexual harassment charges</strong> - The notices come at a time when several wrestlers are protesting at Jantar Mantar.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Punalur suspension bridge reopened</strong> - The renovation of the 135-year-old bridge was carried out as part of Kerala government’s 100-day action plan.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Work on 17.5-km stretch of Chennai - Tirupati highway likely to be completed by September 2024</strong> - This stretch connects Thiruninravur and Tiruvallur and includes construction of three major bridges across waterbodies, six minor bridges and 13 underpasses, all with six provision for lane road</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UK confirms supply of Storm Shadow long-range missiles in Ukraine</strong> - The Storm Shadow cruise missile will give Ukraine new capabilities in its conflict with Russia.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Zelensky says Ukraine needs more time for counter-offensive</strong> - Ukraine’s president says in an interview his country would “lose a lot of people” if it attacks now.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Muharrem Ince: Turkish candidate dramatically pulls out before election</strong> - The main rival to President Erdogan gets a boost from Muharrem Ince’s decision to pull out.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Germany explosion: Police and firefighters hurt in blast at high-rise block</strong> - Officers had responded to reports of a vulnerable person in a high-rise flat, police told the BBC.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mercedes-Benz shooting: Two killed at factory in Germany</strong> - A suspect has been arrested after opening fire at the plant in south-western Germany.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clever hybrid tech impresses with 40 mpg 2023 Honda CR-V Sport</strong> - The SUV uses Honda’s fourth-generation two-motor hybrid system. - <a href="https://arstechnica.com/?p=1938362">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leak of MSI UEFI signing keys stokes fears of “doomsday” supply chain attack</strong> - With no easy way to revoke compromised keys, MSI, and its customers, are in a real pickle. - <a href="https://arstechnica.com/?p=1938422">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google jumps into the AI coding assistant fray with Codey and Studio Bot</strong> - Google says it’s still early days, though. - <a href="https://arstechnica.com/?p=1938356">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dealmaster: Lenovo’s ThinkPad X1 Carbon Gen 10 tops our list</strong> - Plus: discounts on several Mac laptops. - <a href="https://arstechnica.com/?p=1937672">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google’s answer to ChatGPT is now open to everyone in US, packing new features</strong> - More languages, image inputs, and extension support among Bard features at I/O ’23. - <a href="https://arstechnica.com/?p=1938256">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The IRS decides to audit Grandpa, and summons him to the IRS office</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The IRS auditor was not surprised when Grandpa showed up with his attorney.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The auditor said, “Well, sir, you have an extravagant lifestyle and no full-time employment, which you explain by saying that you win money gambling. I’m not sure the IRS finds that believable.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I’m a great gambler, and I can prove it,” says Grandpa. “How about a demonstration?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The auditor thinks for a moment and says, “OK. Go ahead.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Grandpa says, “I’ll bet you a thousand dollars that I can bite my own eye.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The auditor thinks a moment and says, “It’s a bet.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Grandpa removes his glass eye and bites it. The auditor’s jaw drops.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Grandpa says, “Now, I’ll bet you two thousand dollars that I can bite my other eye.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The auditor can tell Grandpa isn’t blind, so he takes the bet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Grandpa removes his dentures and bites his good eye. The stunned auditor now realizes he has wagered and lost three grand, with Grandpa’s attorney as a witness. He starts to get nervous.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Want to go double or nothing?” Grandpa asks. “I’ll bet you six thousand dollars that I can stand on one side of your desk, and pee into that wastebasket on the other side, and never get a drop anywhere in between.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The auditor, twice burned, is cautious now, but decides there’s no way this old guy could possibly manage that stunt, so he agrees again. Grandpa stands beside the desk and unzips his pants, but although he strains mightily, he can’t make the stream reach the wastebasket on the other side, so he pretty much urinates all over the auditor’s desk.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The auditor leaps with joy, realizing that he has just turned a major loss into a huge win. But Grandpa’s attorney moans and puts his head in his hands.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Are you OK?” the auditor asks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Not really,” says the attorney. “This morning, when Grandpa told me he’d been summoned for an audit, he bet me twenty-five thousand dollars that he could come in here and pee all over your desk and that you’d be happy about it.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/HelpingHandsUs"> /u/HelpingHandsUs </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/13e4lyb/the_irs_decides_to_audit_grandpa_and_summons_him/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/13e4lyb/the_irs_decides_to_audit_grandpa_and_summons_him/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>My wife asked me what “mansplaining” means</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
…now what am I supposed to do?
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/VoiceOfSoftware"> /u/VoiceOfSoftware </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/13eayca/my_wife_asked_me_what_mansplaining_means/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/13eayca/my_wife_asked_me_what_mansplaining_means/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Child-proof secret code for sex: “turn on the washing machine tonight, I want to wash my clothes”</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
There was a couple who lived with their 4 year old son. Since they didn’t want to talk about sex in front of the child, they decided to talk in code language. So the code was “turn on the washing machine tonight, I want to wash my clothes”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
That evening the husband requested his son to ask his mom to “turn on the washing machine tonight, I want to wash my clothes”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Child goes running to his mom and delivers the message. Wife who is not in a mood to have sex declines and tells her son to tell his dad that there is no power/electricity, so you can’t wash clothes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
That night the wife feels sorry that she declined, and tells their kid “turn on the washing machine tonight, I want to wash my clothes” and to get ready.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The husband then responds through the kid saying.. “thanks but I hand-washed all my clothes already. “
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/original_don_dada"> /u/original_don_dada </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/13ehlhw/childproof_secret_code_for_sex_turn_on_the/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/13ehlhw/childproof_secret_code_for_sex_turn_on_the/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>When you pull a pin out of a grenade, how do you put it back?</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Urgent and quick answers, plea
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/moneynah"> /u/moneynah </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/13dpw1i/when_you_pull_a_pin_out_of_a_grenade_how_do_you/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/13dpw1i/when_you_pull_a_pin_out_of_a_grenade_how_do_you/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What do a vibrator and a farmer’s alarm clock have in common?</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
They’re both electronic replacements for cocks.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Tilthelastpetalfall"> /u/Tilthelastpetalfall </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/13eba8s/what_do_a_vibrator_and_a_farmers_alarm_clock_have/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/13eba8s/what_do_a_vibrator_and_a_farmers_alarm_clock_have/">[comments]</a></span></p></li>
</ul>
<script>AOS.init();</script></body></html>

4
index.html
View File

File diff suppressed because one or more lines are too long