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<title>12 November, 2020</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-preprints">From Preprints</a></li>
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<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
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<li><a href="#from-pubmed">From PubMed</a></li>
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<li><a href="#from-patent-search">From Patent Search</a></li>
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</ul>
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<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
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<ul>
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<li><strong>Overcoming Anxiety During The Covid-19 Using Five-Finger Hypnotic Therapy</strong> -
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<div>
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COVID-19 is an infectious disease caused by coronavirus 2 Acute respiratory syndrome (Severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2). This Virus can be transmitted from human to human and has spread widely and raises anxiety in all people. People’s anxiety toward Covid-19 should be promptly addressed if unresolved will be poorly engaged. Anxiety towards Covid-19 is higher than the person in general who can lower the quality of life. Anxiety handlers use five-finger hypnotic therapy. Because of the five-finger hypnotic therapy is a process that uses the power of the mind by directing the body to heal self-nourishes health/relaxation through communication in the body involving all visual senses, touch, guidelines, vision, and hearing. The study aims to determine the effect of five-finger hypnotic therapy on anxiety levels in people with Covid-19 mentoring (ODP) at Sari Mutiara Hospital. The research design of the Quasy experiment one group pre-post test. The number of samples used as many as 31 people were selected with the purposive sampling technique. The results showed that the level of anxiety before the five-finger hypnotic therapy was largely in the medium category of 15 people (48.4%) At a severe anxiety level as much as 14 people (45.2%) And at a mild anxiety level as much as 2 people (6.5%). After the five-finger, hypnotic therapy showed that there was a decrease in the number of severe anxiety levels of 2 people (6.5%) Mild anxiety Level 11 people (35.5%) The anxiety level was 18 people (58.1%). The results of this study at Wilcoxon’s statistical test were to get the result of Z = -3,162 and P-value of 0.002 (P < 0.05), there was a significant effect of five-finger hypnotic therapy on the anxiety level of people with Covid-19 (ODP) mentoring.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/q3kew/" target="_blank">Overcoming Anxiety During The Covid-19 Using Five-Finger Hypnotic Therapy</a>
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</div></li>
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<li><strong>Genomic epidemiology of COVID-19 in care homes in the East of England</strong> -
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<div>
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COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, we report on 6,600 COVID-19 cases from the East of England, 1,167 of which were identified as residents from 337 care homes. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data we defined 409 viral clusters within the 292 homes, indicating two different patterns - outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study period, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission between care home residents should be a key target for infection control to reduce COVID-19 mortality in this population.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.08.26.20182279v2" target="_blank">Genomic epidemiology of COVID-19 in care homes in the East of England</a>
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</div></li>
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<li><strong>Socioeconomic Vulnerabilities and the Intensity of RT-PCR SARS-CoV-2 Testing Efforts in the Public Health System in Sao Paulo State</strong> -
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Introduction The testing of infected persons with SARS-CoV-2 is one of the cornerstones to deploy pandemic control strategies. The public diagnostic effort is particularly important among the most vulnerable socioeconomic districts, such as Sao Paulo state, the Brazilian epicenter of the COVID-19 pandemic. Methods We developed an RT-PCR testing intensity effort index (RT-PCR TIEI) composed of seven indicators to assess the intensity testing efforts in the state of Sao Paulo. We used dynamic time-series cross-sectional models to analyze the association between the RT-PCR TIEI in Sao Paulo state, the proportion of the population living under a high socioeconomic vulnerability level, dependent on public health service (SUS), per capita income, and population density. Results On average, the RT-PCR TIEI score was 23.50. The maximum (47.06) was reached in week 11 and declined in subsequent weeks. The lowest score (17.65) was reached in week 25. In the long-run, the RT-PCR TIEI is negatively associated with socioeconomic vulnerability (p-value=0.000, 95% CI -0.896, -0.816), with a higher proportion of the population dependent on SUS (p-value= 0.000, 95% CI -0.877, 0.808) and with population density (p-value=0.000, 95% CI -0.857; -0.806). Conclusion There was a decline in the state9s testing intensity as the pandemic advanced, and the most socioeconomic vulnerable RHDs showed the lowest values where local public laboratory presence is a predictor of a higher RT-PCR TIEI score. Thus, the low testing RT-PCR effort and local laboratory inequality affect surveillance capability, especially for the most socioeconomic vulnerable population.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.10.29.20221960v2" target="_blank">Socioeconomic Vulnerabilities and the Intensity of RT-PCR SARS-CoV-2 Testing Efforts in the Public Health System in Sao Paulo State</a>
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</div></li>
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<li><strong>Efficacy of face masks, neck gaiters and face shields for reducing the expulsion of simulated cough-generated aerosols</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Face masks are recommended to reduce community transmission of SARS-CoV-2. One of the primary benefits of face masks and other coverings is as source control devices to reduce the expulsion of respiratory aerosols during coughing, breathing, and speaking. Face shields and neck gaiters have been proposed as an alternative to face masks, but information about face shields and neck gaiters as source control devices is limited. We used a cough aerosol simulator with a pliable skin headform to propel small aerosol particles (0 to 7 μm) into different face coverings. An N95 respirator blocked 99% of the cough aerosol, a medical grade procedure mask blocked 59%, a 3-ply cotton cloth face mask blocked 51%, and a polyester neck gaiter blocked 47% as a single layer and 60% when folded into a double layer. In contrast, the face shield blocked 2% of the cough aerosol. Our results suggest that face masks and neck gaiters are preferable to face shields as source control devices for cough aerosols.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.10.05.20207241v2" target="_blank">Efficacy of face masks, neck gaiters and face shields for reducing the expulsion of simulated cough-generated aerosols</a>
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</div></li>
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<li><strong>COVID-19 Aerosolized Viral Loads, Environment, Ventilation, Masks, Exposure Time, Severity, And Immune Response: A Pragmatic Guide Of Estimates</strong> -
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It can be shown that over 94% of COVID-19 superspreading events occurred in limited ventilation areas suggesting that aerosolized transmission is a dominant contributor to COVID-19 infections. This study helps answer the questions “How long may a person safely remain within various environments” and “What exposure levels could result in immunity without becoming ill via asymptomatic graduated inoculation”. Understanding how COVID-19 infection likelihood, symptom severity, and immune response correlate to aerosolized viral load concentration exposure levels and time durations could enable optimized Non-Pharmaceutical Interventions (NPI) that reduce severe case counts and improve at-large epidemiologic responses. The model herein estimates the relationships between aerosolized viral load concentrations present in a given environment containing infected persons, the exposure time duration, ventilation, mask usage, exercise / activity level, and likelihood of infection, severity level, and immune response. This study references peer reviewed and published studies and uses them as data sources. Measured aerosolized viral load concentration data from a hospital environment is used to estimate exposure time durations associated with exposures at multiple viral load levels, within multiple indoor ventilation and outdoor environment scenarios, with the exposed subject respirating at both light activity and heavy exercise liter-per-minute volumes, and without and without wearing surgical masks. Information from ASHRAE Office Ventilation standards and an Outdoor Air Exchange model are a part of the model. This estimated total viral load accumulated within specific exposure time durations in the various environmental scenarios is then interpreted using human challenge viral load escalation data into severity categories including Not Ill, Minor Illness, Clinical Mild Illness, and Possible Severe Illness. Immune response data related to these categories is also provided along with discussion related to asymptomatic infection, graduated inoculation, and immunity. When appropriately interpreted for individualized applications, the estimates herein could contribute to guidance for those at low-risk for a severe case that have no obvious COVID-19 co-morbidities, with the understanding that those at higher risk should seek to avoid all exposure risk. The estimates herein may help efforts to strike a balance in developing holistic epidemiologic interventions that consider the effects of these interventions on economic, civic, social, and mental health, which have pathologies within their own realms.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.10.03.20206110v4" target="_blank">COVID-19 Aerosolized Viral Loads, Environment, Ventilation, Masks, Exposure Time, Severity, And Immune Response: A Pragmatic Guide Of Estimates</a>
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</div></li>
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<li><strong>Modelling The Spread of COVID-19 Using The Fundamental Principles of Fluid Dynamics</strong> -
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The increasing number of positive cases of SARS-CoV-2 worldwide led to a catastrophic breakdown in the global economy and unprecedented social disruptions. These measures have significantly impacted the world9s economy and in many cases has led to the loss of livelihood. Mathematical modeling of pandemics is of critical importance to understand the unfolding of transmission events and to formulate appropriate control measures. In this article, we introduce a physics based approach for forecasting epidemics such as COVID-19. The proposed physics-based mathematical model stems from the fundamental principles of fluid dynamics, and can be utilized to make projections of the number of infected people at any scale. Our model takes into account the diffusive transmission of the virus, the growth of virus inside the human body and the response of the natural immune system of individuals. We demonstrate that the health of individuals plays a critical role in controlling the evolution of the epidemic. In places where the individuals exhibit a strong immune system, the development of pandemic is limited despite high diffusivity of the virus. Overall, the proposed mathematical model can be beneficial for predicting and designing potential strategies to mitigate the spread and impact of pandemics.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.06.24.20139071v2" target="_blank">Modelling The Spread of COVID-19 Using The Fundamental Principles of Fluid Dynamics</a>
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</div></li>
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<li><strong>Loneliness during strict lockdown: trajectories and predictors during the COVID-19 pandemic in 38,217 adults in the UK</strong> -
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Rationale: There are increasing worries that lockdowns and stay-at-home orders due to the COVID-19 pandemic could lead to a rise in loneliness, which is recognised as a major public health concern. But profiles of loneliness during the pandemic and risk factors remain unclear. Objective: The current study aimed to examine if and how loneliness levels changed during the strict lockdown and to explore the clustering of loneliness growth trajectories. Methods: Data from 38,217 UK adults in the UCL COVID -19 Social Study (a panel study collecting data weekly during the pandemic) were analysed during the strict lockdown period in the UK (23/03/2020-10/05/2020). The sample was well-stratified and weighted to population proportions of gender, age, ethnicity, education and geographical location. Growth mixture modelling was used to identify the latent classes of loneliness growth trajectories and their predictors. Results: Analyses revealed four classes, with the baseline loneliness level ranging from low to high. In the first a few weeks of lockdown, loneliness levels increased in the highest loneliness group, decreased in the lowest loneliness group, and stayed relatively constant in the middle two groups. Younger adults (OR=2.17-6.81), women (OR=1.59), people with low income (OR=1.3), the economically inactive (OR=1.3-2.04) and people with mental health conditions (OR=5.32) were more likely to be in highest loneliness class relative to the lowest. Further, living with others or in a rural area, and having more close friends or greater social support were protective.
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</p>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.05.29.20116657v2" target="_blank">Loneliness during strict lockdown: trajectories and predictors during the COVID-19 pandemic in 38,217 adults in the UK</a>
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<li><strong>Rational Curiosity and Information-Seeking in the COVID-19 Pandemic</strong> -
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Curiosity is a powerful determinant of behavior. The past decade has seen a surge of scientific research on curiosity, an endeavor recently imbibed with urgency by the WHO, which set managing information-seeking as a public health goal during pandemics. And yet, a fundamental aspect of curiosity has remained unresolved: its relationship to utility. Is curiosity a drive towards information simply for the sake of obtaining that information, or is it a rational drive towards optimal learning? We leveraged people’s curiosity about COVID-19 to study information-seeking and learning in a large sample (n=5376) during the spring of 2020. Our findings reveal that curiosity is goal-rational in that it maximizes the personal utility of learning. Personal utility, unlike normative economic utility, is contingent on a person’s motivational state. On the basis of these findings, we explain information-seeking during the pandemic with a rational theoretical framework for curiosity.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/hcta4/" target="_blank">Rational Curiosity and Information-Seeking in the COVID-19 Pandemic</a>
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</div></li>
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<li><strong>A RECURRENT QUESTION FROM A PRIMARY CARE PHYSICIAN: HOW SHOULD I TREAT MY COVID-19 PATIENTS AT HOME?</strong> -
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<div>
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Rationale and Objectives How should I treat my patients with initial symptoms of COVID-19 at home? This is a recurrent question we have received from many primary care physicians, particularly in less fortunate parts of the world. Given the rising global death toll associated with the COVID-19 pandemic, in the past few months we have witnessed a race to find drugs/biologic treatments to save the lives of hospitalised, severely ill patients, as well as to develop vaccines. To this end, randomised clinical trials are underway to test experimental drug candidates or repurposed medicines. Therapeutic approaches to the early phase of COVID-19 are also being debated, and here, too, there is an emphasis on the need for randomised clinical trials. We agree that rigorous clinical trials are needed. However, there are times, like the present, when patients with SARS-CoV-2 infection are dying at home, and solutions are needed immediately, so we do not have the time to wait for robust results of trials that will take, at best, several months, or possibly up to 1 or 2 years. Thus, it is crucial to provide recommendations to primary care physicians, especially those practicing in resource-poor settings, on treating patients at home during the early phase of COVID-19 when they have mild initial symptoms. Key recommendations We have prepared recommendations for treatment focused on a combination of two drug classes (NSAIDs and corticosteroids) that target the most common symptoms, and prophylactic therapy (low-molecular-weight heparin) and oxygen therapy when needed. These are based on the pathophysiological and pharmacological rationale and the available clinical evidence of efficacy in COVID-19 patients, including results of published randomized clinical trials, for each of our recommended class of drugs. Conclusion These recommendations may be even more helpful to primary care physicians in resource-poor-settings in Latin America and Africa.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/ezwdv/" target="_blank">A RECURRENT QUESTION FROM A PRIMARY CARE PHYSICIAN: HOW SHOULD I TREAT MY COVID-19 PATIENTS AT HOME?</a>
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<li><strong>Place attachment and acceptance of smart city technologies</strong> -
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<div>
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Recent studies on smart cities have emphasised that smart solution initiatives should take into account citizens’ different needs and concerns. The main aim of this paper is to examine the role of different types of place attachment – emotional bonds that residents have with their city – in predicting the acceptance of future smart city technologies. In our study conducted among residents of multiple cities in Poland (N = 627), we found that while active place attachment (i.e. conscious identification with a place) predicted more favourable attitudes towards enabling technologies, traditional (natural and unintentional) place attachment was positively associated with acceptance of surveillance technologies regarding everyday monitoring and anti– Covid-19 measures. We also found that the relationship between place attachment and acceptance of future technologies is partially mediated by the use of existing smart city technologies. The implications for city governments and planners are discussed.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/zrky8/" target="_blank">Place attachment and acceptance of smart city technologies</a>
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<li><strong>Association of coping strategies with mental health trajectories during the first twenty-one weeks of COVID-19 lockdown</strong> -
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The negative impact of the COVID-19 pandemic on mental health is well evidenced. However, there is little research on how individuals’ coping strategies during the pandemic were related to changes in mental health over time. The current study used data from the COVID-19 Social Study (N=26,505) to explore whether particular coping strategies (problem-focused, emotion-focused, avoidant, and supportive) were associated with (i) better mental health as lockdown was introduced, and (ii) faster recovery from symptoms across 21 weeks. People with greater use of problem-focused, avoidant, and supportive coping displayed more mental health symptoms, while greater use of emotion-focused coping was associated with fewer mental health symptoms. Symptoms decreased over time for all coping strategies, but only supportive coping was associated with a faster decrease in anxiety and depressive symptoms, indicating a potential protective effect of social support on psychological distress.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/hy5wb/" target="_blank">Association of coping strategies with mental health trajectories during the first twenty-one weeks of COVID-19 lockdown</a>
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</div></li>
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<li><strong>Lockdown Lives: A longitudinal study of inter-relationships amongst feelings of loneliness, social contacts and solidarity during the COVID-19 lockdown in early 2020.</strong> -
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<div>
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In this work, we study how social contacts and feelings of solidarity shape experiences of loneliness during the COVID-19 lockdown in early 2020. We draw on cross-national data, collected across four time points between mid-March until early May 2020. We situate our work within the public debate on these issues and discuss to what extent the public understanding of the impact of lockdown is borne out in the data. Results show, first, that although online contacts are beneficial in combating feelings of loneliness, people who feel more lonely are less likely to make use of this strategy. Second, online contacts do not function as a substitute to face-to-face contacts - in fact, more frequent online contacts in earlier weeks predicted an increase in face-to-face contacts in later weeks. Finally, solidarity played only a small role in shaping people’s feelings of loneliness during lockdown. In sum, our findings suggest that we must look beyond the current focus on online contact and solidarity, if we want to help people address their feelings of loneliness. We hope that this work will be instrumental not only in understanding the impact of the lockdown in early 2020, but also in preparing for possible future lockdown periods.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/hx5kt/" target="_blank">Lockdown Lives: A longitudinal study of inter-relationships amongst feelings of loneliness, social contacts and solidarity during the COVID-19 lockdown in early 2020.</a>
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<li><strong>THE SOONER THE BETTER? ANXIETY AND DELIBERATE EXPOSURE TO COVID-19 RISK AMONG YOUNG ADULTS IN FRANCE</strong> -
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<div>
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The COVID-19 outbreak has generated significant uncertainty about the future, especially for young adults. Health and economic threats, as well as more diffuse concerns about the consequences of COVID-19, can trigger feelings of anxiety, leading individuals to adopt uncertainty-reducing behaviours. We tested whether anxiety was associated with an increase in willingness to be exposed to the risk of COVID-19 infection (WiRE) using an online survey administered to 3,110 French individuals aged between 18 and 35 years old during the lockdown period (April 2020). Overall, 56.5% of the sample declared a positive WiRE. Unemployment was associated with a higher WiRE (+8.2 percentage points (pp); 95% CI +0.9-15.4 pp). One standard deviation increases in income (+1160€) and psychological state anxiety raised the WiRE by +2.7 pp (95% CI: +1.1-4.4 pp) and +3.9 pp (95% CI: +1.6-6.2 pp), respectively. A one standard deviation increase in perceived hospitalisation risk was associated with a -4.1 pp (95% CI: -6.2-2.1 pp) decrease in the WiRE. Overall, our results suggest that both the prospect of economic losses and psychological anxiety can undermine young adults’ adherence to physical distancing recommendations. Public policies targeting young adults must consider both their economic situation and their mental health, and they must use uncertainty-reducing communication strategies.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/5ntzc/" target="_blank">THE SOONER THE BETTER? ANXIETY AND DELIBERATE EXPOSURE TO COVID-19 RISK AMONG YOUNG ADULTS IN FRANCE</a>
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<li><strong>Voluntary adoption of social welfare-enhancing behavior: Mask-wearing in Spain during the COVID-19 outbreak</strong> -
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With the spread of COVID-19, more countries now recommend their citizens to wear facemasks in public. The uptake of facemasks, however, remains far from universal in countries where this practice lacks cultural roots. In this paper, we aim to identify the barriers to mask-wearing in Spain, a country with no mask-wearing culture. We conduct one of the first nationally representative surveys (n = 4,000) about this unprecedented public health emergency and identify the profile of citizens who are more resistant to face-masking: young, educated, unconcerned with being infected, and with an introverted personality. Our results further indicate a positive correlation between a social norm of mask-wearing and mask uptake and demonstrate that uptake of facemasks is especially high among the elderly living in localities where mask-wearing behavior is popular. These results are robust when controlling for respondents’ demographics, time spent at home, and occupation fixed effects. Our findings can be useful for policymakers to devise effective programs for improving public compliance.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/6m85q/" target="_blank">Voluntary adoption of social welfare-enhancing behavior: Mask-wearing in Spain during the COVID-19 outbreak</a>
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<li><strong>The Pandemic and my PhD: Lessons from a Policy Research Placement with the Reset Initiative</strong> -
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In this brief reflection, I explore three key lessons learned from conducting a policy research placement during the COVID-19 pandemic. I explore how the placement changed my perspective on my PhD research, working life, and suggest how academics may better engage with policymakers in the future.
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🖺 Full Text HTML: <a href="https://psyarxiv.com/jg67m/" target="_blank">The Pandemic and my PhD: Lessons from a Policy Research Placement with the Reset Initiative</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hyperimmune Plasma for Patients With COVID-19</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Other: treated with hyperimmune plasma<br/><b>Sponsor</b>: ANNA FALANGA<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: FSD201; Drug: Placebo<br/><b>Sponsor</b>: FSD Pharma, Inc.<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intravenous Infusion of CAP-1002 in Patients With COVID-19</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Biological: CAP-1002; Biological: Placebo<br/><b>Sponsor</b>: Capricor Inc.<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Clarithromycin 500mg; Drug: Azithromycin; Drug: Placebo<br/><b>Sponsor</b>: South Valley University<br/><b>Completed</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Probiotics in Reducing Symptoms of COVID-19</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Dietary Supplement: Probiotics (2 strains 10x10^9 UFC); Dietary Supplement: Placebo (potato starch and magnesium stearate)<br/><b>Sponsors</b>: Centre de recherche du Centre hospitalier universitaire de Sherbrooke; Lallemand Health Solutions<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: CNM-ZnAg; Drug: Placebo<br/><b>Sponsors</b>: Clene Nanomedicine; ICL Pharma; Azidus Brazil<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mesenchymal Stem Cells in Patients Diagnosed With COVID-19</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Biological: MSC; Other: Control<br/><b>Sponsors</b>: Hospital Reg. Lic. Adolfo Lopez Mateos; Instituto de Terapia Celular: ITC<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Two Hyperimmune Equine Anti Sars-CoV-2 in COVID-19 Patients</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Biological: Administration of Equine immunoglobulin anti SARS-CoV-2<br/><b>Sponsors</b>: Caja Costarricense de Seguro Social; Universidad de Costa Rica; Ministry of Health Costa Rica<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: COVI-VAC; Other: Placebo<br/><b>Sponsor</b>: Codagenix, Inc<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Diagnostic Performance Evaluation of a Novel SARS-CoV-2 (COVID-19) Antigen Detection Test</strong> - <b>Conditions</b>: Covid19; SARS-CoV-2 Infection<br/><b>Interventions</b>: Diagnostic Test: RT-qPCR test; Diagnostic Test: COVID-VIRO® test<br/><b>Sponsor</b>: Centre Hospitalier Régional d’Orléans<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>plasmApuane CoV-2 : Efficacy and Safety of Immune Covid-19 Plasma in Covid-19 Pneumonia in Non ITU Patients</strong> - <b>Condition</b>: Covid-19 Pneumonia<br/><b>Intervention</b>: Biological: immune plasma<br/><b>Sponsor</b>: Azienda USL Toscana Nord Ovest<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the Efficacy of Xylitol Nasal Spray Against SARS-CoV-2</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Drug: Nasal Spray<br/><b>Sponsors</b>: Larkin Community Hospital; Ferrer Medical Innovations; Xlear<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Randomised Study of Plasma Exchange in Severe COVID-19</strong> - <b>Condition</b>: COVID19<br/><b>Intervention</b>: Drug: OCTAPLAS<br/><b>Sponsor</b>: University College, London<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Respiratory Distress</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Device: Hyperbaric Oxygen Therapy (HBOT)<br/><b>Sponsor</b>: NYU Langone Health<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>HLA-G Immuno-Inhibitor Checkpoint Study in Patients With COVID-19 Infection: Molecular and Cellular Assessment</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Other: Baseline and during hospitalization blood samples; Other: Baseline blood sample<br/><b>Sponsor</b>: Hopital Foch<br/><b>Recruiting</b></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational Hot-Spot Analysis of the SARS-CoV-2 Receptor Binding Domain / ACE2 Complex</strong> - Infection and replication of SARS CoV-2 (the virus that causes COVID-19) requires entryto the interior of host cells. In humans, a Protein-Protein Interaction (PPI) between theSARS CoV-2 Receptor-Binding Domain (RBD) and the extracellular peptidase domain ofACE2, on the surface of cells in the lower respiratory tract, is an initial step in the entrypathway. Inhibition of the SARS CoV-2 RBD / ACE2 PPI is currently being evaluated asa target for therapeutic and/or prophylactic intervention….</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The other possible mechanism of the benefits of RAAS inhibition in the athogenesis of COVID-19</strong> - No abstract</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure of nonstructural protein 1 from SARS-CoV-2</strong> - The periodic emergence of novel coronaviruses (CoVs) represents an ongoing public health concern with significant health and financial burden worldwide. The most recent occurrence originated in the city of Wuhan, China where a novel coronavirus (SARS-CoV-2) emerged causing severe respiratory illness and pneumonia. The continual emergence of novel coronaviruses underscores the importance of developing effective vaccines as well as novel therapeutic options that target either viral functions or…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: A proof-of-concept study</strong> - BACKGROUND: Complement pathway inhibition may provide benefit for severe acute respiratory illnesses caused by viral infections such as COVID-19. We present results from a nonrandomized proof-of-concept study of complement C5 inhibitor eculizumab for treatment of severe COVID-19.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Adaptive Evolution of Peptide Inhibitors for Mutating SARS-CoV-2</strong> - The SARS-CoV-2 virus is currently causing a worldwide pandemic with dramatic societal consequences for the humankind. In the past decades, disease outbreaks due to such zoonotic pathogens have appeared with an accelerated rate, which calls for an urgent development of adaptive (smart) therapeutics. Here, a computational strategy is developed to adaptively evolve peptides that could selectively inhibit mutating S protein receptor binding domains (RBDs) of different SARS-CoV-2 viral strains from…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Early Effects of the COVID-19 Pandemic on Physical Activity Locations and Behaviors in Adults Living in the United States</strong> - COVID-19 restrictions and social-distancing may inhibit adults from attaining recommended levels of physical activity. This study examined early impact of COVID-19 pandemic on physical activity in adults during the first two months of restrictions in the U.S. and how physical activity locations were associated with physical activity levels during this period. Adults (N = 268) completed an online survey between April 10-May 25, 2020. Participants reported minutes of vigorous, moderate, and…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biomimetic Human Disease Model of SARS-CoV-2 Induced Lung Injury and Immune Responses on Organ Chip System</strong> - Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The models that can accurately resemble human-relevant responses to viral infection are lacking. Here, we create a biomimetic human disease model on chip that allows to recapitulate lung injury and immune responses induced by SARS-CoV-2 in vitro at organ level. This human alveolar chip reproduced the key features of alveolar-capillary barrier by co-culture of human…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Solar heating to inactivate thermal-sensitive pathogenic microorganisms in vehicles: application to COVID-19</strong> - Disinfection is a common practice to inhibit pathogens, yet success is limited by microbial adaptation and our poor knowledge of viral transmission, notably in the current COVID-19 pandemic. There is a need for alternative disinfection strategies and techniques that are adapted to the actual behavior of humans living in densely populated mega-cities. Here, high public circulation in shared passenger vehicles such as taxis, buses and personal cars represents a major risk of viral transmission due…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Herbal plants coordinate COVID-19 in multiple dimensions - An insight analysis for clinically applied remedies</strong> - The use of multipronged measures, including traditional Chinese medicine (TCM), has greatly increased in response to the COVID-19 pandemic, and we found the use of TCM and is positively correlated with the regional cure rate in China (R=0.77, P<10^(-5)). We analyzed 185 commonly administered TCM recipes comprised of 210 herbs nationwide to reveal mechanistic insight. Eight out of the 10 most commonly used herbs showed anti-coronavirus potential by intersecting with COVID-19 targets….</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives</strong> - Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, effective therapeutic or prophylactic. Like other betacoronaviruses, attachment and entry of SARS-CoV-2 is mediated by the spike glycoprotein (SGP). In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 M(pro) Protease</strong> - Wuhan, China was the epicenter of the first zoonotic transmission of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) in December 2019 and it is the causative agent of the novel human coronavirus disease 2019 (COVID-19). Almost from the beginning of the COVID-19 outbreak several attempts were made to predict possible drugs capable of inhibiting the virus replication. In the present work a drug repurposing study is performed to identify potential SARS-CoV-2 protease…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis</strong> - CONCLUSIONS: We demonstrated that Endovir Stop spray is safe. The next step would be the administration of the efficacy of the spray by testing it to a wider range of people and see whether there is a reduced infection rate of SARS-CoV-2 in the treated subjects than in the non-treated individuals.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19</strong> - CONCLUSIONS: We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets</strong> - CONCLUSIONS: This study, for the first time, revealed the niacin-associated molecular functions and pharmacological targets for treating CRC/COVID-19, as COVID-19 remains a serious pandemic. But the findings were not validated in actual CRC patients infected with COVID-19, so further investigation is needed to confirm the potential use of niacin for treating CRC/COVID-19.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Optimization and Evaluation of Propolis liposomes as a promising therapeutic approach for COVID-19</strong> - The present work aimed to develop an optimized liposomal formulation for enhancing the anti-viral activity of propolis against COVID-19. Docking studies were performed for certain components of Egyptian Propolis using Avigan, Hydroxychloroquine and Remdesivir as standard antivirals against both COVID-19 3CL-protease and S1 spike protein. Response surface methodology and modified injection method were implemented to maximize the entrapment efficiency and release of the liposomal formulation. The…</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 예방을 위한 mRNA기반 항원보강제 혼합물 합성 방법</strong> - 본 발명은 SARS-CoV-2(코로나 바이러스) 예방을 위한 mRNA 항원보강제에 관한 것으로 코로나 바이러스에 대한 백신으로서 상기의 항원에 대한 예방을 목적으로 하고 있다. 아이디어에는 보강제에 해당하는 완전프로인트항원보강제(CFA)와 불완전프로인트항원보강제(IFA), 번역과 안정성의 최적화가 된 mRNA, mRNA 운반체, 양이온성 지질 나노입자(lipid nanoparticles)로 구성되며 기존의 백신에 비해 효율성과 안정성의 측면에서 더 향상된 효과를 가지고 있다.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Methods for treating Arenaviridae and Coronaviridae virus infections</strong> - Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I:</p></li>
|
||||
</ul>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">wherein the ’ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.</p>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Atemschutz-Baukastensystem</strong> -
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Atemschutz-Baukastensystem, das aufweist:</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">eine auf zumindest Mund und Nase einer Person aufsetzbare Maske (1), die einen Eingang (11) und einen Ausgang (12) aufweist, und</li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">mindestens einen Schlauch (3, 31, 32),</li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">wobei sämtliche Komponenten des Atemschutz-Baukastensystems modular ausgebildet und über Steckverbindungen oder Schraubverbindungen (115, 125, 155, 165, 175, 215, 315, 75, 915) miteinander verbindbar sind, um der Maske (1) Luft über deren Eingang (11) zuzuführen und/oder ausgeatmete Luft vom Ausgang (12) der Maske (1) wegzuführen.</li>
|
||||
</ul>
|
||||
<img alt="embedded image" id="EMI-D00000"/>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vorrichtung zur Übergabe und Dekontamination von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen</strong> -
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Vorrichtung zur Übergabe von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen nach einer Dekontamination, umfassend eine Einrichtung zur Dekontamination der mit Krankheitserregern kontaminierten Gegenstände oder Erzeugnisse mit mindestens einer UV-Strahlungsquelle (24), eine Durchzugseinrichtung mit Ein- und/oder Ausgabebereichen für die kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse, dadurch gekennzeichnet, dass die Durchzugseinrichtung im Eingang bzw. im Ausgang zum Ein- und/oder Ausgabebereich angeordnete sich paarweise gegenüberliegende Walzen (17) und Räder (4) umfasst, die zum Einzug bzw. zur Ausgabe der kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse vorgesehen sind, wobei die Walzen (17) und die Räder (4) durch im Ein- und/oder Ausgabebereich angeordnete Sensoren (23) und einer elektronische Kontrolleinheit (27) in Bewegung bringbar sind, wobei die Gegenstände oder Erzeugnisse in den Bereich der Einrichtung zur Dekontamination förderbar sind, der zwischen den paarweise angeordneten Walzen (17) und Rädern (4) vorgesehen ist, welcher sich gegenüberliegende Platten (25) aus Quarzglas oder einem UV-transparenten Polymermaterial, wie Graphen oder Kunstglas umfasst, über bzw. unter welchen die UV-Strahlungsquelle (24) angeordnet ist, welche als UVC-LED-Leiste und/oder Modul mit mindestens einer LED-Lampe ausgebildet ist.</p></li>
|
||||
</ul>
|
||||
<img alt="embedded image" id="EMI-D00000"/>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물</strong> - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. [화학식 1] .</p>
|
||||
<pre><code> JPEG
|
||||
112020094463686-pat00017.jpg
|
||||
48
|
||||
135</code></pre></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>新型冠状病毒中和性抗体滴度检测ELISA试剂盒</strong> - 本发明提供一种新型冠状病毒中和性抗体滴度检测ELISA试剂盒，其中包括：包被有生物素‑链霉亲和素标记的人ACE2蛋白的酶标板、辣根过氧化酶标记的新型冠状病毒RBD蛋白、新型冠状病毒中和性抗体阳性对照、包被液、洗涤液、稀释液、封闭液、显色液和终止液等。该试剂盒具有成本低，操作简单，高灵敏度、高特异性、高准确度的特点，可用于新型冠状病毒中和抗体的批量、快速检测。</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Zahnbürstenaufsatz, elektrische Versorgungseinheit einer elektrischen Zahnbürste, elektrische Zahnbürste mit einem Zahnbürstenaufsatz, Zahnbürste sowie Testaufsatz für eine elektrische Zahnbürste</strong> -</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.</p></li>
|
||||
</ul>
|
||||
<img alt="embedded image" id="EMI-D00000"/>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wasserpfeife mit Hygienefunktion</strong> -
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Hygiene-Mundstückelement (100), aufweisend einen ersten Endabschnitt (103), welcher ausgebildet ist zur Verbindung mit einem Griff-Mundstückelement (200) einer Wasserpfeife (400) und aufweisend einen zweiten Endabschnitt (104), welcher als mundseitiges, freies Ende ausgebildet ist, wobei das Hygiene-Mundstückelement (100) ein erstes Filterelement (101) aufweist, wobei das erste Filterelement (101) wenigstens ein adsorbierendes Material umfasst und/oder wobei das Hygiene-Mundstückelement (100) ein zweites Filterelement (102) aufweist, wobei das zweite Filterelement (102) Metalloxid und/oder elektrostatisch geladene Fasern umfasst.</p></li>
|
||||
</ul>
|
||||
<img alt="embedded image" id="EMI-D00000"/>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
|
||||
<ul>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>알츠하이머병 혹은 뇌졸중의 뉴로인플라마섬의 치료제로서 디디에스 혹은 그 유도체</strong> - 목표 / 배경 :이 연구는 신경-정신과 증상을 측면과 구별하기 위해 2018 ‘NIA-AA 연구 프레임 워크’에 따라 뉴로인플라마섬 경쟁자로서 4, 4’- 디아미노디 페닐설폰(DDS, 디디에스)으로 치료받은 알츠하이머병(AD) 환자를 조사했습니다. 방법 : 서울 연구에서는 AD 진단 기준에 따라 2005 년 1 월부터 2020 년 6 월까지 보관된 소록도 국립병원 EDI 데이터베이스의 AD와 항AD약물(AAD)의 효과를 분석하여 ICD-9와 10 개의 코드를 이용하여 검색 하였습니다. 새로운 바이오마커 (D)를 사용하여 AAD로 인한 AD 증상과 신경정신병적 증상을 관리하여 수치 임상 병기를 분류했습니다. 우리는 서울 연구에서 뉴로인플라마섬 경쟁자로서 뇌경색 및 DDS 관련 사례를 보고합니다. 결과 : DDS는 DDS를 처방했거나 처방하지 않은 사람들과 AD의 비율을 비교할 때 뉴로인플라마섬 경쟁자였습니다. (D)를 도입함으로써, AD의 진행은 NCS 병기 결정을 통해 모니터링 하였습니다. AAD 또는 신경병리 증상을 구별하고 DDS로 치료했습니다. AD는 AAD에 의해 악화될 수 있고 DDS에 의해 경미한 인지 장애로 회복될 수 있습니다. 우리는 서울 연구에서 뇌경색이 발생하기 전과 후에 뉴로인플라마섬 경쟁자로서 DDS가 어떤 역할을 하는지를 임상적으로 확인했습니다. 결론 : DDS는 RBS 분할에 의한 정규/비정규적 우비퀴틴화, NLRP3 inflammasome 형성, Higgins의 캐스케이드 및 철이 풍부한 강자성 나노 입자를 차단하는 역할을 합니다. 바이오마커 (D)를 통하여 DDS로 AD를 예방하고 치료할 수 있습니다. AD에 대한 예방 및 치료 방법으로 뉴로인플라마섬을 치료하는 것을 수치 임상 병기(NCS, Numeric clinical staging)를 통하여 증명하고 있습니다.</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A electronic biometric system</strong> - An electronic biometric system, the system comprising:</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">a biometric detection means arranged to:</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">detect at least one biological characteristic of a person</p></li>
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<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
|
||||
<li><a href="#from-apple-subreddit">From Apple Subreddit</a></li>
|
||||
<li><a href="#from-hacker-news">From Hacker News</a></li>
|
||||
<li><a href="#from-new-yorker">From New Yorker</a></li>
|
||||
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
|
||||
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
|
||||
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
|
||||
<li><a href="#from-ars-technica">From Ars Technica</a></li>
|
||||
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-apple-subreddit">From Apple Subreddit</h1>
|
||||
<ul>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wallpaper Wednesday - [November 11]</strong></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why is there a comical difference in the new MacBook Air specs?</strong></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Select Roku devices and TVs now support AirPlay 2 and HomeKit</strong></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anandtech estimates M1 perf (super detailed write up)</strong></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>With Its Own Chips, Apple Aims to Define the Future of PCs</strong></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-hacker-news">From Hacker News</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Doomsday prepping – Disaster planning for less crazy folk</strong> - <a href="https://news.ycombinator.com/item?id=25060418">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Show HN: Self-hosted offline Internet from your browsing history</strong> - <a href="https://news.ycombinator.com/item?id=25059554">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Introduction to Linear Algebra for Applied Machine Learning with Python</strong> - <a href="https://news.ycombinator.com/item?id=25058619">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Swiss report reveals new details on CIA spying operation</strong> - <a href="https://news.ycombinator.com/item?id=25058783">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Postgres Observability</strong> - <a href="https://news.ycombinator.com/item?id=25058045">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring PGO for the Rust Compiler</strong> - <a href="https://news.ycombinator.com/item?id=25060762">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PySDR: A Guide to SDR and DSP Using Python</strong> - <a href="https://news.ycombinator.com/item?id=25060152">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Are Package Registries Holding Open-Source Hostage?</strong> - <a href="https://news.ycombinator.com/item?id=25059755">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google Fiber 2 Gig</strong> - <a href="https://news.ycombinator.com/item?id=25060515">Comments</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Shasqi (YC W15) Is Hiring Dir Translational Sciences and Dir. Medicinal Chemistry</strong> - <a href="https://news.ycombinator.com/item?id=25060126">Comments</a></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Voting Trump Out Is Not Enough</strong> - The need in this country dwarfs the best of what Joe Biden has put on the table for changing our current condition.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kamala Harris Makes History</strong> - Biden’s selection of Harris is tantamount to an anointment: she is going to be the Democratic Party.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Outside the White House, the Site of Anti-Trump Protests Hosts a Celebration</strong> - Five months ago, protesters in Lafayette Square were tear-gassed to make way for a Presidential photo op. On Saturday, after Joe Biden’s victory was announced, the streets around the square were the scene of a party.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Georgia Republicans Turn Trump’s Baseless Claims of Voter Fraud Into an Electoral Strategy</strong> - In a pair of Senate runoffs, the incumbents, Kelly Loeffler and David Perdue, are clinging tightly to the lame-duck President, hoping his voters will turn out for them in January.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>William Barr Can Stop Donald Trump’s Attempted Coup</strong> - The Attorney General is the one Administration official with the power to discredit the President’s spurious legal claims.</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>West Indies broke COVID isolation rules: NZ official</strong> - The West Indies cricket squad repeatedly broke isolation rules inside their team hotel, New Zealand health officials said Wednesday, adding that the t</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rohit Sharma not on Team India flight to Sydney</strong> - MI skipper expected to travel to NCA</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tata Steel chess tournament cancelled</strong> - This year’s Tata Steel India Rapid and Blitz chess tournament has been cancelled due to the COVID-19 pandemic, the organisers said here on Wednesday.W</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Napoli loses appeal over Juve no-show</strong> - Napoli on Tuesday lost its appeal over a 3-0 defeat and one-point deduction for failing to turn up to play Juventus in October.The Italian Football Fe</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Built to operate at peak efficiency, MI has cracked the T20 code</strong> - The side has all bases covered — fearless top-order batsmen, destructive finishers, match-winning quicks, crafty spinners and a tactically astute captain</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Home Ministry amends FCRA rules</strong> - Norms relaxed for farmer, student, religious and other groups not involved in ‘active politics’.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bhatti faults new farm laws</strong> - ‘TRS govt. dictating terms to farmers on cultivation of crops’</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>U.P. districts now under FRRO ambit</strong> - The Ministry of Home Affairs (MHA) has redefined the jurisdiction of some of the Foreigners Regional Registration Office (FRRO) for services related t</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Slain jawan’s last rites performed with military honours</strong> - CM announces ₹50 lakh aid for bereaved kin, govt. job for one family member</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Marginal dip in State’s daily COVID cases</strong> - 1,196 test positive, five patients succumb to the virus</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nagorno-Karabakh: Protesters in Armenia condemn ‘treacherous’ peace</strong> - They want the prime minister to quit by midnight over a deal to end fighting in the disputed region.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: EU buys 300m doses of BioNTech-Pfizer vaccine</strong> - It comes after early data showed it protects more than 90% of people from developing Covid symptoms.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russian Covid vaccine shows encouraging results</strong> - The full trial results have not yet been published, but scientists welcomed the positive news.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hungary government proposes same-sex adoption ban</strong> - Legislation that would permit only married couples to adopt children is condemned by rights groups.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Several wounded in Remembrance Day bomb attack at Saudi cemetery</strong> - A device exploded as European and US diplomats marked Remembrance Day in Jeddah.</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>US healthcare on brink as COVID-19 hospitalizations hit all-time high</strong> - There’s a “very dark winter” ahead as hospitals struggle to cope and cases keep rising. - <a href="https://arstechnica.com/?p=1722614">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The PlayStation 5 has a hidden Web browser; here’s how to find it</strong> - Twitter login backdoor lets you hop around to any site with a convenient link. - <a href="https://arstechnica.com/?p=1722534">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TikTok says it’s been waiting weeks for a Trump response on US ban</strong> - TikTok parent ByteDance is asking a court to block Trump’s TikTok ban. - <a href="https://arstechnica.com/?p=1722539">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Improperly installed Ring doorbells are catching on fire</strong> - Amazon has issued a recall for 350,000 of its 2nd-generation Ring doorbells. - <a href="https://arstechnica.com/?p=1722571">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ajit Pai urged to accept Trump loss and stop controversial rulemakings</strong> - Dems tell Pai to follow tradition, work only on consensus items during transition. - <a href="https://arstechnica.com/?p=1722563">link</a></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Praying mantises don’t all follow the same religion.</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
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|
||||
They’re in sects.
|
||||
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|
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|
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<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/PeoplesHero87"> /u/PeoplesHero87 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js6gl2/praying_mantises_dont_all_follow_the_same_religion/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js6gl2/praying_mantises_dont_all_follow_the_same_religion/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Bible tells us to love each other.</strong> - <!-- SC_OFF --></p>
|
||||
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|
||||
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|
||||
The Kama Sutra is a little more specific.
|
||||
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|
||||
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|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/pleple_128"> /u/pleple_128 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js53ei/the_bible_tells_us_to_love_each_other/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js53ei/the_bible_tells_us_to_love_each_other/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How many clickbait articles does it take to change a lightbulb?</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The answer will shock you…
|
||||
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|
||||
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|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/wcslater"> /u/wcslater </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js3nfy/how_many_clickbait_articles_does_it_take_to/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js3nfy/how_many_clickbait_articles_does_it_take_to/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What is the difference between a literalist and a kleptomaniac?</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
A comma. A literalist takes everything literally. A kleptomaniac takes everything, literally.
|
||||
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|
||||
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|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Pizzareno"> /u/Pizzareno </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js29m4/what_is_the_difference_between_a_literalist_and_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js29m4/what_is_the_difference_between_a_literalist_and_a/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>My girlfriend dressed up as a policewoman and told me I was under arrest on suspicion of being good in bed.</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
After 2 minutes all charges were dropped due to a lack of evidence.
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||||
</p>
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||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/F12BIXXH"> /u/F12BIXXH </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/js14zi/my_girlfriend_dressed_up_as_a_policewoman_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/js14zi/my_girlfriend_dressed_up_as_a_policewoman_and/">[comments]</a></span></p></li>
|
||||
</ul>
|
||||
|
||||
|
||||
<script>AOS.init();</script></body></html>
|
||||
|
|
@ -13,9 +13,9 @@ Archive | Daily Reports
|
|||
<li> <a href="#covid-19">Covid-19</a>
|
||||
</li></li></ul>
|
||||
<h2 id="daily-dose">Daily Dose</h2>
|
||||
<ul id="daily-dose-list"><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
|
||||
<ul id="daily-dose-list"><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
|
||||
</ul>
|
||||
<h2 id="covid-19">Covid-19</h2>
|
||||
<ul id="covid-19-list"><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
|
||||
<ul id="covid-19-list"><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
|
||||
</ul>
|
||||
</body></html>
|
||||
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Reference in New Issue