+COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, we report on 6,600 COVID-19 cases from the East of England, 1,167 of which were identified as residents from 337 care homes. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data we defined 409 viral clusters within the 292 homes, indicating two different patterns - outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study period, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission between care home residents should be a key target for infection control to reduce COVID-19 mortality in this population. +
++Introduction The testing of infected persons with SARS-CoV-2 is one of the cornerstones to deploy pandemic control strategies. The public diagnostic effort is particularly important among the most vulnerable socioeconomic districts, such as Sao Paulo state, the Brazilian epicenter of the COVID-19 pandemic. Methods We developed an RT-PCR testing intensity effort index (RT-PCR TIEI) composed of seven indicators to assess the intensity testing efforts in the state of Sao Paulo. We used dynamic time-series cross-sectional models to analyze the association between the RT-PCR TIEI in Sao Paulo state, the proportion of the population living under a high socioeconomic vulnerability level, dependent on public health service (SUS), per capita income, and population density. Results On average, the RT-PCR TIEI score was 23.50. The maximum (47.06) was reached in week 11 and declined in subsequent weeks. The lowest score (17.65) was reached in week 25. In the long-run, the RT-PCR TIEI is negatively associated with socioeconomic vulnerability (p-value=0.000, 95% CI -0.896, -0.816), with a higher proportion of the population dependent on SUS (p-value= 0.000, 95% CI -0.877, 0.808) and with population density (p-value=0.000, 95% CI -0.857; -0.806). Conclusion There was a decline in the state9s testing intensity as the pandemic advanced, and the most socioeconomic vulnerable RHDs showed the lowest values where local public laboratory presence is a predictor of a higher RT-PCR TIEI score. Thus, the low testing RT-PCR effort and local laboratory inequality affect surveillance capability, especially for the most socioeconomic vulnerable population. +
++Face masks are recommended to reduce community transmission of SARS-CoV-2. One of the primary benefits of face masks and other coverings is as source control devices to reduce the expulsion of respiratory aerosols during coughing, breathing, and speaking. Face shields and neck gaiters have been proposed as an alternative to face masks, but information about face shields and neck gaiters as source control devices is limited. We used a cough aerosol simulator with a pliable skin headform to propel small aerosol particles (0 to 7 μm) into different face coverings. An N95 respirator blocked 99% of the cough aerosol, a medical grade procedure mask blocked 59%, a 3-ply cotton cloth face mask blocked 51%, and a polyester neck gaiter blocked 47% as a single layer and 60% when folded into a double layer. In contrast, the face shield blocked 2% of the cough aerosol. Our results suggest that face masks and neck gaiters are preferable to face shields as source control devices for cough aerosols. +
++It can be shown that over 94% of COVID-19 superspreading events occurred in limited ventilation areas suggesting that aerosolized transmission is a dominant contributor to COVID-19 infections. This study helps answer the questions “How long may a person safely remain within various environments” and “What exposure levels could result in immunity without becoming ill via asymptomatic graduated inoculation”. Understanding how COVID-19 infection likelihood, symptom severity, and immune response correlate to aerosolized viral load concentration exposure levels and time durations could enable optimized Non-Pharmaceutical Interventions (NPI) that reduce severe case counts and improve at-large epidemiologic responses. The model herein estimates the relationships between aerosolized viral load concentrations present in a given environment containing infected persons, the exposure time duration, ventilation, mask usage, exercise / activity level, and likelihood of infection, severity level, and immune response. This study references peer reviewed and published studies and uses them as data sources. Measured aerosolized viral load concentration data from a hospital environment is used to estimate exposure time durations associated with exposures at multiple viral load levels, within multiple indoor ventilation and outdoor environment scenarios, with the exposed subject respirating at both light activity and heavy exercise liter-per-minute volumes, and without and without wearing surgical masks. Information from ASHRAE Office Ventilation standards and an Outdoor Air Exchange model are a part of the model. This estimated total viral load accumulated within specific exposure time durations in the various environmental scenarios is then interpreted using human challenge viral load escalation data into severity categories including Not Ill, Minor Illness, Clinical Mild Illness, and Possible Severe Illness. Immune response data related to these categories is also provided along with discussion related to asymptomatic infection, graduated inoculation, and immunity. When appropriately interpreted for individualized applications, the estimates herein could contribute to guidance for those at low-risk for a severe case that have no obvious COVID-19 co-morbidities, with the understanding that those at higher risk should seek to avoid all exposure risk. The estimates herein may help efforts to strike a balance in developing holistic epidemiologic interventions that consider the effects of these interventions on economic, civic, social, and mental health, which have pathologies within their own realms. +
++The increasing number of positive cases of SARS-CoV-2 worldwide led to a catastrophic breakdown in the global economy and unprecedented social disruptions. These measures have significantly impacted the world9s economy and in many cases has led to the loss of livelihood. Mathematical modeling of pandemics is of critical importance to understand the unfolding of transmission events and to formulate appropriate control measures. In this article, we introduce a physics based approach for forecasting epidemics such as COVID-19. The proposed physics-based mathematical model stems from the fundamental principles of fluid dynamics, and can be utilized to make projections of the number of infected people at any scale. Our model takes into account the diffusive transmission of the virus, the growth of virus inside the human body and the response of the natural immune system of individuals. We demonstrate that the health of individuals plays a critical role in controlling the evolution of the epidemic. In places where the individuals exhibit a strong immune system, the development of pandemic is limited despite high diffusivity of the virus. Overall, the proposed mathematical model can be beneficial for predicting and designing potential strategies to mitigate the spread and impact of pandemics. +
++Rationale: There are increasing worries that lockdowns and stay-at-home orders due to the COVID-19 pandemic could lead to a rise in loneliness, which is recognised as a major public health concern. But profiles of loneliness during the pandemic and risk factors remain unclear. Objective: The current study aimed to examine if and how loneliness levels changed during the strict lockdown and to explore the clustering of loneliness growth trajectories. Methods: Data from 38,217 UK adults in the UCL COVID -19 Social Study (a panel study collecting data weekly during the pandemic) were analysed during the strict lockdown period in the UK (23/03/2020-10/05/2020). The sample was well-stratified and weighted to population proportions of gender, age, ethnicity, education and geographical location. Growth mixture modelling was used to identify the latent classes of loneliness growth trajectories and their predictors. Results: Analyses revealed four classes, with the baseline loneliness level ranging from low to high. In the first a few weeks of lockdown, loneliness levels increased in the highest loneliness group, decreased in the lowest loneliness group, and stayed relatively constant in the middle two groups. Younger adults (OR=2.17-6.81), women (OR=1.59), people with low income (OR=1.3), the economically inactive (OR=1.3-2.04) and people with mental health conditions (OR=5.32) were more likely to be in highest loneliness class relative to the lowest. Further, living with others or in a rural area, and having more close friends or greater social support were protective. +
+Hyperimmune Plasma for Patients With COVID-19 - Condition: Covid19
Intervention: Other: treated with hyperimmune plasma
Sponsor: ANNA FALANGA
Recruiting
Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19 - Condition: COVID-19
Interventions: Drug: FSD201; Drug: Placebo
Sponsor: FSD Pharma, Inc.
Not yet recruiting
Intravenous Infusion of CAP-1002 in Patients With COVID-19 - Condition: Covid19
Interventions: Biological: CAP-1002; Biological: Placebo
Sponsor: Capricor Inc.
Recruiting
Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection - Condition: Covid19
Interventions: Drug: Clarithromycin 500mg; Drug: Azithromycin; Drug: Placebo
Sponsor: South Valley University
Completed
Efficacy of Probiotics in Reducing Symptoms of COVID-19 - Condition: COVID-19
Interventions: Dietary Supplement: Probiotics (2 strains 10x10^9 UFC); Dietary Supplement: Placebo (potato starch and magnesium stearate)
Sponsors: Centre de recherche du Centre hospitalier universitaire de Sherbrooke; Lallemand Health Solutions
Not yet recruiting
Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants - Condition: Covid19
Interventions: Drug: CNM-ZnAg; Drug: Placebo
Sponsors: Clene Nanomedicine; ICL Pharma; Azidus Brazil
Not yet recruiting
Mesenchymal Stem Cells in Patients Diagnosed With COVID-19 - Condition: Covid19
Interventions: Biological: MSC; Other: Control
Sponsors: Hospital Reg. Lic. Adolfo Lopez Mateos; Instituto de Terapia Celular: ITC
Recruiting
Efficacy and Safety of Two Hyperimmune Equine Anti Sars-CoV-2 in COVID-19 Patients - Condition: Covid19
Intervention: Biological: Administration of Equine immunoglobulin anti SARS-CoV-2
Sponsors: Caja Costarricense de Seguro Social; Universidad de Costa Rica; Ministry of Health Costa Rica
Recruiting
Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19 - Condition: COVID-19
Interventions: Biological: COVI-VAC; Other: Placebo
Sponsor: Codagenix, Inc
Not yet recruiting
Diagnostic Performance Evaluation of a Novel SARS-CoV-2 (COVID-19) Antigen Detection Test - Conditions: Covid19; SARS-CoV-2 Infection
Interventions: Diagnostic Test: RT-qPCR test; Diagnostic Test: COVID-VIRO® test
Sponsor: Centre Hospitalier Régional d’Orléans
Recruiting
plasmApuane CoV-2 : Efficacy and Safety of Immune Covid-19 Plasma in Covid-19 Pneumonia in Non ITU Patients - Condition: Covid-19 Pneumonia
Intervention: Biological: immune plasma
Sponsor: Azienda USL Toscana Nord Ovest
Recruiting
Evaluation of the Efficacy of Xylitol Nasal Spray Against SARS-CoV-2 - Condition: Covid19
Intervention: Drug: Nasal Spray
Sponsors: Larkin Community Hospital; Ferrer Medical Innovations; Xlear
Recruiting
Randomised Study of Plasma Exchange in Severe COVID-19 - Condition: COVID19
Intervention: Drug: OCTAPLAS
Sponsor: University College, London
Recruiting
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Respiratory Distress - Condition: Covid19
Intervention: Device: Hyperbaric Oxygen Therapy (HBOT)
Sponsor: NYU Langone Health
Not yet recruiting
HLA-G Immuno-Inhibitor Checkpoint Study in Patients With COVID-19 Infection: Molecular and Cellular Assessment - Condition: Covid19
Interventions: Other: Baseline and during hospitalization blood samples; Other: Baseline blood sample
Sponsor: Hopital Foch
Recruiting
Computational Hot-Spot Analysis of the SARS-CoV-2 Receptor Binding Domain / ACE2 Complex - Infection and replication of SARS CoV-2 (the virus that causes COVID-19) requires entryto the interior of host cells. In humans, a Protein-Protein Interaction (PPI) between theSARS CoV-2 Receptor-Binding Domain (RBD) and the extracellular peptidase domain ofACE2, on the surface of cells in the lower respiratory tract, is an initial step in the entrypathway. Inhibition of the SARS CoV-2 RBD / ACE2 PPI is currently being evaluated asa target for therapeutic and/or prophylactic intervention….
The other possible mechanism of the benefits of RAAS inhibition in the athogenesis of COVID-19 - No abstract
Structure of nonstructural protein 1 from SARS-CoV-2 - The periodic emergence of novel coronaviruses (CoVs) represents an ongoing public health concern with significant health and financial burden worldwide. The most recent occurrence originated in the city of Wuhan, China where a novel coronavirus (SARS-CoV-2) emerged causing severe respiratory illness and pneumonia. The continual emergence of novel coronaviruses underscores the importance of developing effective vaccines as well as novel therapeutic options that target either viral functions or…
Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: A proof-of-concept study - BACKGROUND: Complement pathway inhibition may provide benefit for severe acute respiratory illnesses caused by viral infections such as COVID-19. We present results from a nonrandomized proof-of-concept study of complement C5 inhibitor eculizumab for treatment of severe COVID-19.
Adaptive Evolution of Peptide Inhibitors for Mutating SARS-CoV-2 - The SARS-CoV-2 virus is currently causing a worldwide pandemic with dramatic societal consequences for the humankind. In the past decades, disease outbreaks due to such zoonotic pathogens have appeared with an accelerated rate, which calls for an urgent development of adaptive (smart) therapeutics. Here, a computational strategy is developed to adaptively evolve peptides that could selectively inhibit mutating S protein receptor binding domains (RBDs) of different SARS-CoV-2 viral strains from…
Early Effects of the COVID-19 Pandemic on Physical Activity Locations and Behaviors in Adults Living in the United States - COVID-19 restrictions and social-distancing may inhibit adults from attaining recommended levels of physical activity. This study examined early impact of COVID-19 pandemic on physical activity in adults during the first two months of restrictions in the U.S. and how physical activity locations were associated with physical activity levels during this period. Adults (N = 268) completed an online survey between April 10-May 25, 2020. Participants reported minutes of vigorous, moderate, and…
Biomimetic Human Disease Model of SARS-CoV-2 Induced Lung Injury and Immune Responses on Organ Chip System - Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The models that can accurately resemble human-relevant responses to viral infection are lacking. Here, we create a biomimetic human disease model on chip that allows to recapitulate lung injury and immune responses induced by SARS-CoV-2 in vitro at organ level. This human alveolar chip reproduced the key features of alveolar-capillary barrier by co-culture of human…
Solar heating to inactivate thermal-sensitive pathogenic microorganisms in vehicles: application to COVID-19 - Disinfection is a common practice to inhibit pathogens, yet success is limited by microbial adaptation and our poor knowledge of viral transmission, notably in the current COVID-19 pandemic. There is a need for alternative disinfection strategies and techniques that are adapted to the actual behavior of humans living in densely populated mega-cities. Here, high public circulation in shared passenger vehicles such as taxis, buses and personal cars represents a major risk of viral transmission due…
Herbal plants coordinate COVID-19 in multiple dimensions - An insight analysis for clinically applied remedies - The use of multipronged measures, including traditional Chinese medicine (TCM), has greatly increased in response to the COVID-19 pandemic, and we found the use of TCM and is positively correlated with the regional cure rate in China (R=0.77, P<10^(-5)). We analyzed 185 commonly administered TCM recipes comprised of 210 herbs nationwide to reveal mechanistic insight. Eight out of the 10 most commonly used herbs showed anti-coronavirus potential by intersecting with COVID-19 targets….
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives - Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, effective therapeutic or prophylactic. Like other betacoronaviruses, attachment and entry of SARS-CoV-2 is mediated by the spike glycoprotein (SGP). In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been…
Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 M(pro) Protease - Wuhan, China was the epicenter of the first zoonotic transmission of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) in December 2019 and it is the causative agent of the novel human coronavirus disease 2019 (COVID-19). Almost from the beginning of the COVID-19 outbreak several attempts were made to predict possible drugs capable of inhibiting the virus replication. In the present work a drug repurposing study is performed to identify potential SARS-CoV-2 protease…
Pilot study for the evaluation of safety profile of a potential inhibitor of SARS-CoV-2 endocytosis - CONCLUSIONS: We demonstrated that Endovir Stop spray is safe. The next step would be the administration of the efficacy of the spray by testing it to a wider range of people and see whether there is a reduced infection rate of SARS-CoV-2 in the treated subjects than in the non-treated individuals.
Natural compounds as inhibitors of SARS-CoV-2 endocytosis: A promising approach against COVID-19 - CONCLUSIONS: We reviewed natural compounds with potential antiviral activity against SARS-CoV-2 that could be used as a treatment for COVID-19.
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets - CONCLUSIONS: This study, for the first time, revealed the niacin-associated molecular functions and pharmacological targets for treating CRC/COVID-19, as COVID-19 remains a serious pandemic. But the findings were not validated in actual CRC patients infected with COVID-19, so further investigation is needed to confirm the potential use of niacin for treating CRC/COVID-19.
Optimization and Evaluation of Propolis liposomes as a promising therapeutic approach for COVID-19 - The present work aimed to develop an optimized liposomal formulation for enhancing the anti-viral activity of propolis against COVID-19. Docking studies were performed for certain components of Egyptian Propolis using Avigan, Hydroxychloroquine and Remdesivir as standard antivirals against both COVID-19 3CL-protease and S1 spike protein. Response surface methodology and modified injection method were implemented to maximize the entrapment efficiency and release of the liposomal formulation. The…
SARS-CoV-2 예방을 위한 mRNA기반 항원보강제 혼합물 합성 방법 - 본 발명은 SARS-CoV-2(코로나 바이러스) 예방을 위한 mRNA 항원보강제에 관한 것으로 코로나 바이러스에 대한 백신으로서 상기의 항원에 대한 예방을 목적으로 하고 있다. 아이디어에는 보강제에 해당하는 완전프로인트항원보강제(CFA)와 불완전프로인트항원보강제(IFA), 번역과 안정성의 최적화가 된 mRNA, mRNA 운반체, 양이온성 지질 나노입자(lipid nanoparticles)로 구성되며 기존의 백신에 비해 효율성과 안정성의 측면에서 더 향상된 효과를 가지고 있다.
Methods for treating Arenaviridae and Coronaviridae virus infections - Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I:
wherein the ’ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
++Atemschutz-Baukastensystem, das aufweist:
+Vorrichtung zur Übergabe von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen nach einer Dekontamination, umfassend eine Einrichtung zur Dekontamination der mit Krankheitserregern kontaminierten Gegenstände oder Erzeugnisse mit mindestens einer UV-Strahlungsquelle (24), eine Durchzugseinrichtung mit Ein- und/oder Ausgabebereichen für die kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse, dadurch gekennzeichnet, dass die Durchzugseinrichtung im Eingang bzw. im Ausgang zum Ein- und/oder Ausgabebereich angeordnete sich paarweise gegenüberliegende Walzen (17) und Räder (4) umfasst, die zum Einzug bzw. zur Ausgabe der kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse vorgesehen sind, wobei die Walzen (17) und die Räder (4) durch im Ein- und/oder Ausgabebereich angeordnete Sensoren (23) und einer elektronische Kontrolleinheit (27) in Bewegung bringbar sind, wobei die Gegenstände oder Erzeugnisse in den Bereich der Einrichtung zur Dekontamination förderbar sind, der zwischen den paarweise angeordneten Walzen (17) und Rädern (4) vorgesehen ist, welcher sich gegenüberliegende Platten (25) aus Quarzglas oder einem UV-transparenten Polymermaterial, wie Graphen oder Kunstglas umfasst, über bzw. unter welchen die UV-Strahlungsquelle (24) angeordnet ist, welche als UVC-LED-Leiste und/oder Modul mit mindestens einer LED-Lampe ausgebildet ist.
제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. [화학식 1] .
+ JPEG
+ 112020094463686-pat00017.jpg
+ 48
+ 135新型冠状病毒中和性抗体滴度检测ELISA试剂盒 - 本发明提供一种新型冠状病毒中和性抗体滴度检测ELISA试剂盒，其中包括：包被有生物素‑链霉亲和素标记的人ACE2蛋白的酶标板、辣根过氧化酶标记的新型冠状病毒RBD蛋白、新型冠状病毒中和性抗体阳性对照、包被液、洗涤液、稀释液、封闭液、显色液和终止液等。该试剂盒具有成本低，操作简单，高灵敏度、高特异性、高准确度的特点，可用于新型冠状病毒中和抗体的批量、快速检测。
Zahnbürstenaufsatz, elektrische Versorgungseinheit einer elektrischen Zahnbürste, elektrische Zahnbürste mit einem Zahnbürstenaufsatz, Zahnbürste sowie Testaufsatz für eine elektrische Zahnbürste -
++
Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.
+Hygiene-Mundstückelement (100), aufweisend einen ersten Endabschnitt (103), welcher ausgebildet ist zur Verbindung mit einem Griff-Mundstückelement (200) einer Wasserpfeife (400) und aufweisend einen zweiten Endabschnitt (104), welcher als mundseitiges, freies Ende ausgebildet ist, wobei das Hygiene-Mundstückelement (100) ein erstes Filterelement (101) aufweist, wobei das erste Filterelement (101) wenigstens ein adsorbierendes Material umfasst und/oder wobei das Hygiene-Mundstückelement (100) ein zweites Filterelement (102) aufweist, wobei das zweite Filterelement (102) Metalloxid und/oder elektrostatisch geladene Fasern umfasst.
알츠하이머병 혹은 뇌졸중의 뉴로인플라마섬의 치료제로서 디디에스 혹은 그 유도체 - 목표 / 배경 :이 연구는 신경-정신과 증상을 측면과 구별하기 위해 2018 ‘NIA-AA 연구 프레임 워크’에 따라 뉴로인플라마섬 경쟁자로서 4, 4’- 디아미노디 페닐설폰(DDS, 디디에스)으로 치료받은 알츠하이머병(AD) 환자를 조사했습니다. 방법 : 서울 연구에서는 AD 진단 기준에 따라 2005 년 1 월부터 2020 년 6 월까지 보관된 소록도 국립병원 EDI 데이터베이스의 AD와 항AD약물(AAD)의 효과를 분석하여 ICD-9와 10 개의 코드를 이용하여 검색 하였습니다. 새로운 바이오마커 (D)를 사용하여 AAD로 인한 AD 증상과 신경정신병적 증상을 관리하여 수치 임상 병기를 분류했습니다. 우리는 서울 연구에서 뉴로인플라마섬 경쟁자로서 뇌경색 및 DDS 관련 사례를 보고합니다. 결과 : DDS는 DDS를 처방했거나 처방하지 않은 사람들과 AD의 비율을 비교할 때 뉴로인플라마섬 경쟁자였습니다. (D)를 도입함으로써, AD의 진행은 NCS 병기 결정을 통해 모니터링 하였습니다. AAD 또는 신경병리 증상을 구별하고 DDS로 치료했습니다. AD는 AAD에 의해 악화될 수 있고 DDS에 의해 경미한 인지 장애로 회복될 수 있습니다. 우리는 서울 연구에서 뇌경색이 발생하기 전과 후에 뉴로인플라마섬 경쟁자로서 DDS가 어떤 역할을 하는지를 임상적으로 확인했습니다. 결론 : DDS는 RBS 분할에 의한 정규/비정규적 우비퀴틴화, NLRP3 inflammasome 형성, Higgins의 캐스케이드 및 철이 풍부한 강자성 나노 입자를 차단하는 역할을 합니다. 바이오마커 (D)를 통하여 DDS로 AD를 예방하고 치료할 수 있습니다. AD에 대한 예방 및 치료 방법으로 뉴로인플라마섬을 치료하는 것을 수치 임상 병기(NCS, Numeric clinical staging)를 통하여 증명하고 있습니다.
A electronic biometric system - An electronic biometric system, the system comprising:
a biometric detection means arranged to:
detect at least one biological characteristic of a person
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Voting Trump Out Is Not Enough - The need in this country dwarfs the best of what Joe Biden has put on the table for changing our current condition.
Kamala Harris Makes History - Biden’s selection of Harris is tantamount to an anointment: she is going to be the Democratic Party.
Outside the White House, the Site of Anti-Trump Protests Hosts a Celebration - Five months ago, protesters in Lafayette Square were tear-gassed to make way for a Presidential photo op. On Saturday, after Joe Biden’s victory was announced, the streets around the square were the scene of a party.
Georgia Republicans Turn Trump’s Baseless Claims of Voter Fraud Into an Electoral Strategy - In a pair of Senate runoffs, the incumbents, Kelly Loeffler and David Perdue, are clinging tightly to the lame-duck President, hoping his voters will turn out for them in January.
William Barr Can Stop Donald Trump’s Attempted Coup - The Attorney General is the one Administration official with the power to discredit the President’s spurious legal claims.
West Indies broke COVID isolation rules: NZ official - The West Indies cricket squad repeatedly broke isolation rules inside their team hotel, New Zealand health officials said Wednesday, adding that the t
Rohit Sharma not on Team India flight to Sydney - MI skipper expected to travel to NCA
Tata Steel chess tournament cancelled - This year’s Tata Steel India Rapid and Blitz chess tournament has been cancelled due to the COVID-19 pandemic, the organisers said here on Wednesday.W
Napoli loses appeal over Juve no-show - Napoli on Tuesday lost its appeal over a 3-0 defeat and one-point deduction for failing to turn up to play Juventus in October.The Italian Football Fe
Built to operate at peak efficiency, MI has cracked the T20 code - The side has all bases covered — fearless top-order batsmen, destructive finishers, match-winning quicks, crafty spinners and a tactically astute captain
Home Ministry amends FCRA rules - Norms relaxed for farmer, student, religious and other groups not involved in ‘active politics’.
Bhatti faults new farm laws - ‘TRS govt. dictating terms to farmers on cultivation of crops’
U.P. districts now under FRRO ambit - The Ministry of Home Affairs (MHA) has redefined the jurisdiction of some of the Foreigners Regional Registration Office (FRRO) for services related t
Slain jawan’s last rites performed with military honours - CM announces ₹50 lakh aid for bereaved kin, govt. job for one family member
Marginal dip in State’s daily COVID cases - 1,196 test positive, five patients succumb to the virus
Nagorno-Karabakh: Protesters in Armenia condemn ‘treacherous’ peace - They want the prime minister to quit by midnight over a deal to end fighting in the disputed region.
Coronavirus: EU buys 300m doses of BioNTech-Pfizer vaccine - It comes after early data showed it protects more than 90% of people from developing Covid symptoms.
Russian Covid vaccine shows encouraging results - The full trial results have not yet been published, but scientists welcomed the positive news.
Hungary government proposes same-sex adoption ban - Legislation that would permit only married couples to adopt children is condemned by rights groups.
Several wounded in Remembrance Day bomb attack at Saudi cemetery - A device exploded as European and US diplomats marked Remembrance Day in Jeddah.
US healthcare on brink as COVID-19 hospitalizations hit all-time high - There’s a “very dark winter” ahead as hospitals struggle to cope and cases keep rising. - link
The PlayStation 5 has a hidden Web browser; here’s how to find it - Twitter login backdoor lets you hop around to any site with a convenient link. - link
TikTok says it’s been waiting weeks for a Trump response on US ban - TikTok parent ByteDance is asking a court to block Trump’s TikTok ban. - link
Improperly installed Ring doorbells are catching on fire - Amazon has issued a recall for 350,000 of its 2nd-generation Ring doorbells. - link
Ajit Pai urged to accept Trump loss and stop controversial rulemakings - Dems tell Pai to follow tradition, work only on consensus items during transition. - link
Praying mantises don’t all follow the same religion. -
++They’re in sects. +
+ submitted by /u/PeoplesHero87
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The Bible tells us to love each other. -
++The Kama Sutra is a little more specific. +
+ submitted by /u/pleple_128
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How many clickbait articles does it take to change a lightbulb? -
++The answer will shock you… +
+ submitted by /u/wcslater
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What is the difference between a literalist and a kleptomaniac? -
++A comma. A literalist takes everything literally. A kleptomaniac takes everything, literally. +
+ submitted by /u/Pizzareno
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My girlfriend dressed up as a policewoman and told me I was under arrest on suspicion of being good in bed. -
++After 2 minutes all charges were dropped due to a lack of evidence. +
+ submitted by /u/F12BIXXH
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