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<title>09 November, 2022</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-preprints">From Preprints</a></li>
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<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
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<li><a href="#from-pubmed">From PubMed</a></li>
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<li><a href="#from-patent-search">From Patent Search</a></li>
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</ul>
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<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
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<ul>
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<li><strong>Optimization of the Illumina COVIDSeq™ protocol for decentralized, cost-effective genomic surveillance</strong> -
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<div>
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A decentralized surveillance system to identify local outbreaks and monitor SARS-CoV-2 Variants of Concern is one of the primary strategies for the pandemic’s containment. Although next-generation sequencing (NGS) is a gold standard for genomic surveillance and variant discovery, the technology is still cost-prohibitive for decentralized sequencing, particularly in small independent labs with limited resources. We have optimized the Illumina COVID-seq protocol to reduce cost without compromising accuracy. 90% of genomic coverage was achieved for 142/153 samples analyzed in this study. The lineage was correctly assigned to all samples (152/153) except for one. This modified protocol can help laboratories with constrained resources contribute to decentralized SARS-CoV-2 surveillance in the post-vaccination era.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.07.515545v1" target="_blank">Optimization of the Illumina COVIDSeq™ protocol for decentralized, cost-effective genomic surveillance</a>
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</div></li>
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<li><strong>Normalized Semi-Covariance Co-Efficiency Analysis of Spike Proteins from SARS-CoV-2 variant Omicron and Other Coronaviruses for their Infectivity and Virulence</strong> -
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<div>
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Spectrum-based Mass-Charge modeling is increasingly used in biological analysis. To explain statistical phenomenon with positive and negative fluctuations of amino acid charges in spike protein sequences from Omicron and other coronaviruses, we propose calculation-based Mass-Charge modeling, a normalized derivation algorithm with exact Excel and MATLAB tool involving separate quadrant extension to normalized covariance, which is still compatible with Pearson covariance co-efficiency. The number of amino acids, molecular weight, isoelectric point, amino acid composition, charged residues, mass-charge ratio, hydropathicity of the proteins were taken into consideration in the analyses, and the relative peak and dip of the average with spike protein sequences based on hydrophobic mass to isoelectric charges of amino acids were also examined. The analyses with the algorithm provide more clear insights leading to revealing underline evolving trends of the viral proteins. Spike proteins from SARS-CoV-2 variants, seasonal and murine coronaviruses were taken as representative examples in this study. The analyses demonstrate that the Mass-Charge covariance co-efficiency can distinguish subtle differences between biological properties of spike proteins and correlate well with viral infectivity and virulence.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.07.515557v1" target="_blank">Normalized Semi-Covariance Co-Efficiency Analysis of Spike Proteins from SARS-CoV-2 variant Omicron and Other Coronaviruses for their Infectivity and Virulence</a>
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</div></li>
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<li><strong>Prediction of Transport, Deposition, and Resultant Immune Response of Nasal Spray Vaccine Droplets using a CFPD-HCD Model in a 6-Year-Old Upper Airway Geometry to Potentially Prevent COVID-19</strong> -
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<div>
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This study focuses on the transport, deposition, and triggered immune response of intranasal vaccine droplets to the Angiotensin-converting enzyme 2-rich region (i.e., the olfactory region (OR)) in the nasal cavity of a 6-year-old female to possibly prevent COVID-19. To investigate how administration strategy can influence nasal vaccine efficiency, a validated multiscale model (i.e., computational fluid-particle dynamics (CFPD) and host-cell dynamics (HCD) model) was employed. Droplet deposition fraction, size change, residence time, and the area percentage of OR covered by the vaccine droplets and triggered immune system response were predicted with different spray cone angles, initial droplet velocities, and compositions. Numerical results indicate that droplet initial velocity and composition have negligible influences on the vaccine delivery efficiency to OR. In contrast, the spray cone angle can significantly impact vaccine delivery efficiency. The triggered immunity was not significantly influenced by the administration investigated in this study, due to the low percentage of OR area covered by the droplets. To enhance the effectiveness of the intranasal vaccine to prevent COVID-19 infection, it is necessary to optimize the vaccine formulation and administration strategy so that the vaccine droplets can cover more epithelial cells in OR to minimize the available receptors for SARS-CoV-2.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.08.515673v1" target="_blank">Prediction of Transport, Deposition, and Resultant Immune Response of Nasal Spray Vaccine Droplets using a CFPD-HCD Model in a 6-Year-Old Upper Airway Geometry to Potentially Prevent COVID-19</a>
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</div></li>
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<li><strong>Too much is too much: influence of former stress levels on food cravings and weight gain during the COVID-19 period</strong> -
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<div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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The COVID-19 pandemic and associated social restrictions had an extensive effect on peoples’ lives. Increased rates of weight gain were widely reported, as were declines in the general populations’ mental health, including increases in perceived stress. This study investigated whether higher perceived levels of stress during the pandemic were associated with greater levels of weight gain, and whether poor prior levels of mental health were a factor in higher levels of both stress and weight gain during the pandemic. Underlying changes in eating behaviours and dietary consumption were also investigated. During January-February 2021, UK adults (n=179) completed a self-report online questionnaire to measure perceived levels of stress and changes (current versus pre-COVID-19 restrictions) in weight, eating behaviours, dietary consumption, and physical activity. Participants also reported on how COVID-19 had impacted their lives and their level of mental health prior to the pandemic. Participants with higher levels of stress were significantly more likely to report weight gain and twice as likely to report increased food cravings and comfort food consumption (OR=2.3 and 1.9-2.5, respectively). Participants reporting an increase in food cravings were 6-11 times more likely to snack and to have increased consumption of high sugar or processed foods (OR=6.3, 11.2 and 6.3, respectively). Females reported a far greater number of COVID-19 enforced lifestyle changes and both female gender and having poor mental health prior to the pandemic were significant predictors of higher stress and weight gain during the pandemic. Although COVID-19 and the pandemic restrictions were unprecedented, this study suggests that understanding and addressing the disparity of higher perceived stress in females and individuals’ previous levels of mental health, as well as the key role of food cravings, is key for successfully addressing the continuing societal issue of weight gain and obesity.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.06.22282004v1" target="_blank">Too much is too much: influence of former stress levels on food cravings and weight gain during the COVID-19 period</a>
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</div></li>
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<li><strong>Understanding public support for COVID-19 pandemic mitigation measures over time: Does it wear out?</strong> -
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<div>
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COVID-19 mitigation measures intend to protect public health, but their adverse psychological, social, and economic effects weaken popular support. Less favorable trade-offs may especially weaken support for more restrictive measures. Support for mitigation measures may also differ between population subgroups who experience different benefits and costs, and decrease over time, a phenomenon termed ‘pandemic fatigue’. We examined self-reported support for COVID-19 mitigation measures in The Netherlands over 12 consecutives waves of data collection between April 2020 – May 2021 in an open population cohort study. Participants were recruited through community panels of the 25 regional public health services, and through links to the online surveys advertised on social media. The 54,010 unique participants in the cohort study on average participated in 4 waves of data collection. Most participants were female (65%), middle-aged (57% 40-69 years), highly educated (57%), not living alone (84%), residing in an urban area (60%), and born in the Netherlands (95%). COVID-19 mitigation measures implemented in the Netherlands remained generally well-supported over time (all scores >3 on 5-point scale ranging 1 (low) – 5 (high)). During the whole period studied, support was highest for personal hygiene measures, quarantine and wearing face masks, high but somewhat lower for not shaking hands, testing and self-isolation, and restricting social contacts, and lowest for limiting visitors at home, and not traveling abroad. Women and higher educated people were more supportive of some mitigation measures than men and lower educated people. Older people were more supportive of more restrictive measures than younger people, and support for more socially restrictive measures decreased most over time in higher educated people or in younger people. This study found no support for pandemic fatigue in terms of a gradual decline in support for all mitigation measures over time. Rather, findings suggest that support for mitigation measures reflects a balancing of benefits and cost, which may change over time, and differ between measures and population subgroups.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/yq2az/" target="_blank">Understanding public support for COVID-19 pandemic mitigation measures over time: Does it wear out?</a>
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</div></li>
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<li><strong>Computer Simulation of the interaction between SARS-CoV-2 Spike Protein and the Surface of Coinage Metals</strong> -
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<div>
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A prominent feature of the SARS-CoV-2 virus is the presence of a large glycoprotein spike protruding from the virus envelope. The spike determines the interaction of the virus with the environment and the host. Here, we used an all-atom molecular dynamics simulation method to investigate the interaction of up and down conformations of the S1 subunit of the SARS-CoV-2 spike with the (100) surface of Au, Ag and Cu. Our results revealed that the spike protein is adsorbed onto the surface of these metals, being Cu the metal with the highest interaction with the spike. In our simulations, we considered the spike protein in both its up conformation Sup (one receptor binding domain exposed) and down conformation Sdown (no exposed receptor binding domain). We found that the affinity of the metals for the up conformation was higher than their affinity for the down conformation. The structural changes in the Spike in the up conformation were also larger than the changes in the down conformation. Comparing the present results for metals with those obtained in our previous MD simulations of Sup with other materials (cellulose, graphite, and human skin models), we see that Au induces the highest structural change in Sup, larger than those obtained in our previous studies.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.28.501856v2" target="_blank">Computer Simulation of the interaction between SARS-CoV-2 Spike Protein and the Surface of Coinage Metals</a>
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</div></li>
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<li><strong>“The new gay plague”: qualitative analysis of public attitudes toward monkeypox</strong> -
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<div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Monkeypox was declared a public health emergency on August 4, 2022, in the United States. The emerging isolation of the virus in the LGBTQ+ community—particularly among gay, bisexual, and men who have sex with men (GBMSM)—has led many to draw parallels between the emerging multi-country outbreak and the 1980s HIV/AIDS crisis. The purpose of this study was to investigate media framing of the monkeypox outbreak in American media through the lens of HIV social constructionist theory. Content analysis of a sample of 59 articles from the top-five most viewed U.S. media outlets was collated against quantitative trends in word frequencies in monkeypox-related tweets (n = 255,363). Results found that coverage often framed monkeypox as a product of GBMSM hypersexuality, leading to potentially stigmatizing perceptions and the drastic increase in tweet content related to sexual activity. While greater attention to stigma was observed in coverage, blame attribution to populations, governments, and practices was one of the most common frames across all media sources. Heavy reporting of systemic barriers to vaccination, testing, or diagnosis serve as continuities from HIV/AIDS and COVID-19 epidemics, underscoring fears around a second plague and influencing public attitudes. Monkeypox conspiracy theories also proliferated heavily on Twitter, with a noticeable increase in conspiracy language over time. These findings can inform the social realities of monkeypox, an understudied dimension, of which an understanding is vital to implementing services that address all elements of the ongoing outbreak.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.01.22281797v1" target="_blank">“The new gay plague”: qualitative analysis of public attitudes toward monkeypox</a>
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</div></li>
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<li><strong>Bivalent BNT162b2mRNA original/Omicron BA.4-5 booster vaccination: adverse reactions and inability to work compared to the monovalent COVID-19 booster</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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In the light of emerging SARS CoV 2 variants of concern (VOC), bivalent COVID 19 vaccines combining the wild-type spike mRNA with an Omicron VOC BA.1 or BA.4-5 spike mRNA became available. This non randomized controlled study examined adverse reactions, PRN (pro re nata) medication intake and inability to work after a fourth COVID-19 vaccination among 76 healthcare workers. As fourth dose either the original, monovalent BNT162b2mRNA (48.7%) or the bivalent BNT162b2mRNA original/Omicron BA.4-5 vaccine (51.3%) was administered. The rate of adverse reactions for the second booster dose was significantly higher among participants receiving the bivalent 84.6% (95% CI 70.3%-92.8%; 33/39) compared to the monovalent 51.4% (95% CI 35.9-66.6%; 19/37) vaccine (p=0.0028). Also, there was a trend towards an increased rate of inability to work and intake of PRN medication following bivalent vaccination. In view of preprints reporting inconclusive results in neutralizing antibody levels between the compared vaccines, our results and further studies on safety and reactogenicity of bivalent COVID-19 booster vaccines are highly important to aid clinical decision making in the choice between bivalent and monovalent vaccinations.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.07.22281982v1" target="_blank">Bivalent BNT162b2mRNA original/Omicron BA.4-5 booster vaccination: adverse reactions and inability to work compared to the monovalent COVID-19 booster</a>
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</div></li>
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<li><strong>Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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With more recent SARS-CoV-2 variants, breakthrough infections in vaccinated individuals and reinfections among previously infected individuals are increasingly common, especially during the Omicron wave. Such infections have led to concerns about controlling transmission and underscore a broader need to understand the contribution of vaccination, including booster doses, and natural immunity to the infectiousness of persons with SARS-CoV-2 infections, especially in high-risk populations with intense transmission such as prisons. Here, we show that both vaccine-derived and naturally acquired immunity independently reduce the infectiousness of persons with Omicron variant SARS-CoV-2 infections in a prison setting. Analyzing data from system-wide SARS-CoV-2 surveillance across 35 California state prisons with a predominately male population, we estimate that Omicron variant infections among unvaccinated cases had a 36% (95% confidence interval (CI): 31-42%) risk of transmitting to close contacts, as compared to 28% (25-31%) risk among vaccinated cases. In adjusted analyses, we estimated that any vaccination, prior infection alone, and both vaccination and prior infection reduced an index case9s risk of transmitting to close contacts by 22% (6-36%), 23% (3-39%) and 40% (20-55%), respectively. Receipt of booster doses and more recent vaccination further reduced infectiousness among vaccinated cases. These findings suggest that although vaccinated and/or previously infected individuals remain highly infectious upon SARS-CoV-2 infection in this prison setting, their infectiousness is reduced compared to individuals without any history of vaccination or infection.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.08.08.22278547v4" target="_blank">Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave</a>
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</div></li>
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<li><strong>Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19 related olfactory disorders</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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It is estimated that 20-67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of this study was to provide a proof-of-concept that SCENTinel 1.1, a rapid, inexpensive, population-wide olfactory test, can discriminate between anosmia (total smell loss), hyposmia (reduced sense of smell), parosmia (distorted odor perception), and phantosmia (odor sensation without a source). Participants were mailed a SCENTinel 1.1 test, which measures odor detection, intensity, identification, and pleasantness, using one of four possible odors. Those who completed the test (N = 381) were divided into groups based on their self-reported olfactory function: quantitative olfactory disorder (anosmia or hyposmia, N = 135), qualitative olfactory disorder (parosmia and/or phantosmia; N = 86), and normosmia (normal sense of smell; N = 66). SCENTinel 1.1 accurately discriminates quantitative olfactory disorders, qualitative olfactory disorders, and normosmia groups. When olfactory disorders were assessed individually, SCENTinel 1.1 discriminates between hyposmia, parosmia and anosmia. Participants with parosmia rated common odors less pleasant than those without parosmia. We provide proof-of-concept that SCENTinel 1.1, a rapid smell test, can discriminate quantitative and qualitative olfactory disorders, and is the only direct test to rapidly discriminate parosmia.
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</p>
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.23.22272807v2" target="_blank">Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19 related olfactory disorders</a>
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<li><strong>An Analysis of e-Commerce Development in Vietnam and Policy Implications for Business after COVID-19</strong> -
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The paper aims to clarify the development of e-commerce in Vietnam, an emerging economy in Southeast Asia. The survey data for the analysis was carried out by the Vietnam e-Commerce and Digital Economy Agency included 4466 enterprises. The study period is two years, from 2019 to 2020. Employing the thematic analysis approach, the study results reveal that e-commerce has been popularly applied in many business activities. E-commerce has helped businesses stabilize supply chains to cope with strict social distancing measures to fight the epidemic. Besides, a large number of companies confirm that e-commerce is necessary for faster business recovery in the post-COVID-19 pandemic era. The result also confirms that e-commerce continues to play an important role in helping enterprises advance to a new normal status in business in the next years. The study has some contributions when highlighting the critical role of e-commerce not only during the outbreak of the pandemic, but also regarding business recovery in the coming time.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/dvq9j/" target="_blank">An Analysis of e-Commerce Development in Vietnam and Policy Implications for Business after COVID-19</a>
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</div></li>
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<li><strong>Cohort profile: The Corona Behavioural Unit COVID-19 cohort, a longitudinal mixed-methods study on COVID-19-related behaviour, well-being and policy support in the Netherlands</strong> -
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<div>
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In response to the COVID-19 pandemic in the Netherlands, the National Institute of Public Health and the Environment (RIVM) established a longitudinal collaborative cohort study to examine adherence to COVID-19 behaviours, its psychosocial determinants, participant well-being, trust in the Dutch government, with additional attention for COVID-19 test and vaccination uptake. The cohort profile gives a comprehensive description of the cohort’s recruitment and its mixed-method design.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/drvq9/" target="_blank">Cohort profile: The Corona Behavioural Unit COVID-19 cohort, a longitudinal mixed-methods study on COVID-19-related behaviour, well-being and policy support in the Netherlands</a>
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<li><strong>Stress, coping, and quality of life in the United States during the COVID-19 pandemic</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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While research has widely explored stress, coping, and quality of life (QOL) individually and the potential links between them, there is a critical dearth in the literature regarding these constructs in the context of the COVID-19 pandemic. Our study aims to identify the salient stressors experienced, describe the coping strategies used, and examine the relationships between stress, coping, and current QOL among individuals during the pandemic. Data are from a nationally representative sample of 1,004 respondents who completed an online survey. Key measures included stressful life events (SLEs), coping strategies, and the physical and psychological health domains of QOL. Staged multivariate linear regression analyses examined the relationships between the two QOL domains and SLEs, controlling for sociodemographic and pre-existing health conditions and testing for the effects of coping strategies on these relationships. The most common SLEs experienced during the pandemic were a decrease in financial status, personal injury or illness, and change in living conditions. Problem-focused coping and emotion-focused coping were significantly related to higher levels of QOL, whereas avoidant coping was associated with lower QOL. Avoidant coping partially mediated the relationship between experiencing SLEs and reduced physical and psychological QOL. Our study informs clinical interventions to help individuals adopt healthy behaviors to effectively manage stressors, especially large-scale traumatic events like the pandemic. Our findings also call for public health and clinical interventions to address the long-term impacts of the most prevalent stressors experienced during the pandemic among vulnerable groups.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.03.22281899v1" target="_blank">Stress, coping, and quality of life in the United States during the COVID-19 pandemic</a>
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</div></li>
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<li><strong>Changes in Alcohol Consumption during the COVID-19 Pandemic: Evidence from Wisconsin</strong> -
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Introduction: The COVID-19 pandemic increased stress levels broadly in the general population. Patterns of alcohol consumption are known to increase in times of increased stress like natural disasters, disease outbreaks, and economic turmoil. Wisconsin is an important place to study changes in alcohol consumption because it is one of the heaviest-drinking states in the United States. The primary aim of this study is to identify changes in alcohol use at three distinct timepoints during the COVID-19 pandemic in a statewide sample. Methods: An online survey was sent to 5,502 previous Survey of the Health of Wisconsin (SHOW) participants to ask about a wide range of topics related to COVID-19. The timepoints were taken May through June 2020 (Wave 1), January to February 2021 (Wave 2), and June 2021 (Wave 3) The sample included 1,290, 1,868, and 1,585 participants in each of the three waves respectively. Changes in alcohol consumption (whether they drank more, about the same, or less) were examined by race, age, gender, educational attainment, annual income, anxiety and depression status, remote work status, whether the participant experienced employment changes due to COVID-19, and whether there were children present in the home. Within-wave univariate changes in alcohol consumption were evaluated by demographics using a chi-squared test. Results: In all three waves, those with anxiety, a bachelors degree or higher, two younger age groups, and those with children in the home were significantly more likely to increase alcohol consumption. Those reporting depression, those in the highest income quartile, and those working remotely were more likely to report increased drinking in the first two surveys, but not in the third survey. Participants reporting changes in employment due to COVID-19 were more likely to increase drinking in the first survey only. Non-white participants were more likely to report decreased drinking in the first survey only. Conclusions: There may be subpopulations in Wisconsin at higher risk for the negative effects of heavy drinking during the pandemic like those with anxiety, those with children in the home, those with a bachelors degree or higher, and those in younger age groups, as these groups had consistently higher alcohol use that did not subside 15 months after lockdowns began.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.07.22282029v1" target="_blank">Changes in Alcohol Consumption during the COVID-19 Pandemic: Evidence from Wisconsin</a>
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<li><strong>Systematic review of the prevalence of Long Covid</strong> -
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Background: Long Covid occurs in those infected with SARSCoV2 whose symptoms persist or develop beyond the acute phase. We conducted a systematic review to determine the prevalence of persistent symptoms, functional disability or pathological changes in adults or children at least 12 weeks post-infection. Methods: We searched MEDLINE (Ovid), Embase (OVID), the Cochrane Covid-19 Study register, WHO ICTRP, medRxiv, Cochrane CENTRAL, MEDLINE (PubMed), ClinicalTrials.gov, and the WHO Global research on coronavirus disease (COVID-19) database from 1st January 2020 to 2nd November 2021, limited to publications in English. We included studies with at least 100 participants. Studies where all participants were critically ill were excluded. Articles were screened independently by two reviewers, with disagreements resolved by a third. Long Covid (primary outcome) was extracted as prevalence of at least one symptom or pathology, or prevalence of the most common symptom or pathology, at 12 weeks or later. Heterogeneity was quantified in absolute terms and as a proportion of total variation and explored across pre-defined subgroups (PROSPERO ID CRD42020218351). Findings: In total 120 studies in 130 publications were included. Length of follow-up varied from 12 weeks to over 12 months. Few studies had low risk of bias. All complete and subgroup analyses except one had I2 ≥ 90%, with prevalence of persistent symptoms ranging between 0% and 93%. Studies using routine healthcare records tended to report lower prevalence of persistent symptoms/pathology than self-report. However, studies systematically investigating pathology in all participants at follow up tended to report the highest estimates of all three. Studies of hospitalised cases had generally higher estimates than community-based studies. Interpretation: The way in which Long Covid is defined and measured affects prevalence estimation. Given the widespread nature of SARSCoV2 infection globally, the burden of chronic illness is likely to be substantial even using the most conservative estimates.
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</p>
|
||||
</div>
|
||||
<div class="article-link article-html-link">
|
||||
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.06.22281979v1" target="_blank">Systematic review of the prevalence of Long Covid</a>
|
||||
</div></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Bivalent Booster Megastudy</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Behavioral: COVID Booster text messages<br/><b>Sponsor</b>: University of Pennsylvania<br/><b>Enrolling by invitation</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Using a Community-level Just-in-Time Adaptive Intervention to Address COVID-19 Testing Disparities</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Behavioral: Multi-Level Multi-Component Intervention (MLI); Behavioral: Community Just-In-Time Adaptive Intervention (Community JITAI)<br/><b>Sponsors</b>: The University of Texas Health Science Center, Houston; National Center for Advancing Translational Sciences (NCATS)<br/><b>Active, not recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Medications COVID-19</strong> - <b>Condition</b>: Severe Covid-19<br/><b>Intervention</b>: Drug: Oral bedtime melatonin<br/><b>Sponsor</b>: Hospital San Carlos, Madrid<br/><b>Completed</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Use of Multiple Doses of Convalescent Plasma in Mechanically Intubated Patients With COVID-19</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Biological: Multiple doses of anti-SARS-CoV-2 Convalescent Plasma<br/><b>Sponsors</b>: Hospital Regional Dr. Rafael Estévez; Complejo Hospitalario Dr. Arnulfo Arias Madrid; Hospital Santo Tomas; Hospital Punta Pacífica, Pacífica Salud; Insituto Conmemorativo Gorgas de Estudios para la Salud; Sociedad Panameña de Hematología; Institute of Scientific Research and High Technology Services (INDICASAT AIP); University of Panama; Sistema Nacional de Investigación de Panamá<br/><b>Completed</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Examining How a Facilitated Self-Sampling Intervention and Testing Navigation Intervention Influences COVID-19 Testing</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Behavioral: Facilitated Self-Sampling Intervention (FSSI); Behavioral: Testing Navigation Intervention (TNI).; Behavioral: Control<br/><b>Sponsors</b>: The University of Texas Health Science Center, Houston; National Center for Advancing Translational Sciences (NCATS)<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Assessing Performance of the Testing Done Simple Covid 19 Antigen Test</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Diagnostic Test: Testing Done Simple SARS CoV-2 Antigen Test<br/><b>Sponsors</b>: Testing Done Simple; Nao Medical Urgent Care<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase III of COVID-19 Vaccine EuCorVac-19 in Healthy Adults Aged 18 Years and Older</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: EuCorVac-19; Biological: ChAdOx1<br/><b>Sponsor</b>: EuBiologics Co.,Ltd<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Open Multicenter Study for Assessment of Efficacy and Safety of Molnupiravir in Adult Patients With COVID-19</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: Molnupiravir (Esperavir); Drug: Standard of care<br/><b>Sponsor</b>: Promomed, LLC<br/><b>Completed</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Open Multicentre Study of the Safety and Efficacy Against COVID-19 of Nirmatrelvir/Ritonavir in the Adult Population</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: nirmatrelvir/ritonavir; Drug: Standard of care<br/><b>Sponsors</b>: Promomed, LLC; Sponsor GmbH<br/><b>Completed</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study Evaluating GS-5245 in Participants With COVID-19 Who Have a High Risk of Developing Serious or Severe Illness</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: GS-5245; Drug: GS-5245 Placebo<br/><b>Sponsor</b>: Gilead Sciences<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Respiratory Muscle Training in Individuals With Long-term Post-COVID-19 Symptoms</strong> - <b>Conditions</b>: Covid19; Post-acute COVID-19 Syndrome<br/><b>Interventions</b>: Other: Inspiratory + expiratory muscle training group; Other: Inspiratory + expiratory muscle training sham group; Other: Exercise training program<br/><b>Sponsors</b>: Universidad Complutense de Madrid; Colegio Profesional de Fisioterapeutas de la Comunidad de Madrid<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recombinant COVID-19 Vaccine (CHO Cell, NVSI-06-09) Phase III Clinical Trial</strong> - <b>Conditions</b>: COVID-19; Coronavirus Infections<br/><b>Interventions</b>: Biological: LIBP-Rec-Vaccine; Biological: BIBP-Rec-Vaccine; Biological: placebo<br/><b>Sponsors</b>: National Vaccine and Serum Institute, China; China National Biotec Group Company Limited; Lanzhou Institute of Biological Products Co., Ltd; Beijing Institute of Biological Products Co Ltd.<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Combined Modified RNA Vaccine Candidates Against COVID-19 and Influenza</strong> - <b>Conditions</b>: Influenza, Human; COVID-19<br/><b>Interventions</b>: Biological: bivalent BNT162b2 (original/Omi BA.4/BA.5); Biological: qIRV (22/23); Biological: QIV<br/><b>Sponsors</b>: BioNTech SE; Pfizer<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate Safety, Tolerability, Efficacy and Pharmacokinetics of ASC10 in Mild to Moderate COVID-19 Patients</strong> - <b>Condition</b>: SARS CoV 2 Infection<br/><b>Interventions</b>: Drug: ASC10; Drug: Placebo<br/><b>Sponsor</b>: Ascletis Pharmaceuticals Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase I/II Study of GLB-COV2-043 as a COVID-19 Vaccine Booster</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: GLB-COV2-043; Drug: BNT162b2/COMIRNATY®<br/><b>Sponsor</b>: GreenLight Biosciences, Inc.<br/><b>Not yet recruiting</b></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Two-helix supramolecular proteomimetic binders assembled via PNA-assisted disulfide cross-linking</strong> - Peptidic motifs folded in a defined conformation are able to inhibit protein-protein interactions (PPIs) covering large interfaces and as such they are biomedical molecules of interest. Mimicry of such natural structures with synthetically tractable constructs often requires complex scaffolding and extensive optimization to preserve the fidelity of binding to the target. Here, we present a novel proteomimetic strategy based on a 2-helix binding motif that is brought together by hybridization of…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Determination of Binding Affinity of Tunicamycin with SARS-CoV-2 Proteins: Proteinase, Protease, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, Envelope and RBD of Spike Glycoprotein</strong> - Introduction: Despite the availability of several COVID-19 vaccines, the incidence of infections remains a serious issue. Tunicamycin (TM), an antibiotic, inhibited tumor growth, reduced coronavirus envelope glycoprotein subunit 2 synthesis, and decreased N-linked glycosylation of coronavirus glycoproteins. Objectives: Our study aimed to determine how tunicamycin interacts with certain coronavirus proteins (proteinase, protease, nsp9, ORF7a, ORF3a, ORF9b, ORF8, envelope protein, nsp2, and RBD of…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Environmental Impacts on COVID-19: Mechanisms of Increased Susceptibility</strong> - CONCLUSIONS: Exposure to particulate matter (PM) pollution enhanced morbidity and mortality to COVID-19 in a pediatric population associated with induction of oxidative stress. In addition, free radicals present on PM can induce rapid changes in the viral genome that can lead to vaccine escape, altered host susceptibility, and viral pathogenicity. Nutritional antioxidant supplements have been shown to reduce the severity of viral infections, inhibit the inflammatory cytokine storm, and boost…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral response</strong> - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, causes respiratory failure and damage to multiple organ systems. The emergence of viral variants poses a risk of vaccine failures and prolongation of the pandemic. However, our understanding of the molecular basis of SARS-CoV-2 infection and subsequent COVID-19 pathophysiology is limited. In this study, we have uncovered a critical role for the evolutionarily conserved…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge</strong> - The Mediterranean diet is a dietary pattern typical of the populations living in the Mediterranean basin during the 50s-60s of the last century. This diet has demonstrated beneficial effects in the prevention of several pathologies such as cardiovascular diseases, metabolic syndrome, or several cancer types, at least in part, due to its antioxidant compounds. Since the COVID-19 pandemic started, different authors have been studying the effects of certain dietary habits on the presence of…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Automated detection of neutralizing SARS-CoV-2 antibodies in minutes using a competitive chemiluminescence immunoassay</strong> - The SARS-CoV-2 pandemic has shown the importance of rapid and comprehensive diagnostic tools. While there are numerous rapid antigen tests available, rapid serological assays for the detection of neutralizing antibodies are and will be needed to determine not only the amount of antibodies formed after infection or vaccination but also their neutralizing potential, preventing the cell entry of SARS-CoV-2. Current active-virus neutralization assays require biosafety level 3 facilities, while…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Quest for mRNA Vaccines</strong> - The success of mRNA vaccines against COVID-19 is nothing short of a medical revolution. Given its chemical lability the use of mRNA as a therapeutic has been counterintuitive and met with skepticism. The development of mRNA-based COVID-19 vaccines was the culmination of long and painstaking efforts by many investigators spanning over 30 years and culminating with the seminal studies of Kariko and Weissman. This review will describe one chapter in this saga, studies that have shown that mRNA can…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages</strong> - Human respiratory syncytial virus (hRSV) infection is a leading cause of severe respiratory tract infections. Effective, directly acting antivirals against hRSV are not available. We aimed to discover new and chemically diverse candidates to enrich the hRSV drug development pipeline. We used a two-step screen that interrogates compound efficacy after primary infection and a consecutive virus passaging. We resynthesized selected hit molecules and profiled their activities with hRSV lentiviral…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Advances And Challenges In Using Nirmatrelvir And Its Derivatives Against Sars-Cov-2 Infection</strong> - On 22 December 2021, the United States Food and Drug Administration (FDA) approved the first M^(pro) inhibitor, i.e., oral antiviral nirmatrelvir (PF-07321332)/ritonavir (Paxlovid), for the treatment of early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Nirmatrelvir inhibits SARS-CoV-2 infection, but high doses or long-term treatment may cause embryonic developmental toxicity and changes in host gene expression. The chiral structure of nirmatrelvir plays a key role in…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protocol for characterizing the inhibition of SARS-CoV-2 infection by a protein of interest in cultured cells</strong> - Here, we present a protocol to characterize the antiviral ability of a protein of interest to SARS-CoV-2 infection in cultured cells, using MUC1 as an example. We use SARS-CoV-2 ΔN trVLP system, which utilizes transcription and replication-competent SARS-CoV-2 virus-like particles lacking nucleocapsid gene. We describe the optimized procedure to analyze protein interference of viral attachment and entry into cells, and qRT-PCR-based quantification of viral infection. The protocol can be applied…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Current insights and molecular docking studies of the drugs under clinical trial as rdrp inhibitors in COVID-19 treatment</strong> - CONCLUSION: The drug repurposing approach provides a new avenue in COVID-19 treatment.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Insight into the role of clathrin-mediated endocytosis inhibitors in SARS-CoV-2 infection</strong> - Emergence of SARS-CoV-2 variants warrants sustainable efforts to upgrade both the diagnostic and therapeutic protocols. Understanding the details of cellular and molecular basis of the virus-host cell interaction is essential for developing variant-independent therapeutic options. The internalization of SARS-CoV-2, into lung epithelial cells, is mediated by endocytosis, especially clathrin-mediated endocytosis (CME). Although vaccination is the gold standard strategy against viral infection,…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cytotoxicity may involve inhibition of peroxisome proliferator-activated receptor alpha. Fenofibrate activates peroxisome proliferator-activated receptor alpha and inhibits SARS-CoV-2 replication in vitro. Whether fenofibrate can be used to treat coronavirus disease 2019 (COVID-19) infection in humans remains unknown. Here, we randomly assigned inpatients and outpatients with COVID-19 within 14 d of symptom onset to 145 mg of oral…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 public health and social measures: a comprehensive picture of six Asian countries</strong> - The COVID-19 pandemic will not be the last of its kind. As the world charts a way towards an equitable and resilient recovery, Public Health and Social Measures (PHSMs) that were implemented since the beginning of the pandemic need to be made a permanent feature of health systems that can be activated and readily deployed to tackle sudden surges in infections going forward. Although PHSMs aim to blunt the spread of the virus, and in turn protect lives and preserve health system capacity, there…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Use of a Bacterial Artificial Chromosome to Generate Recombinant SARS-CoV-2 Expressing Robust Levels of Reporter Genes</strong> - Reporter-expressing recombinant virus represents an excellent option and a powerful tool to investigate, among others, viral infection, pathogenicity, and transmission, as well as to identify therapeutic compounds that inhibit viral infection and prophylactic vaccines. To combat the ongoing coronavirus disease 2019 (COVID-19) pandemic, we have established a robust bacterial artificial chromosome (BAC)-based reverse genetics (RG) system to rapidly generate recombinant severe acute respiratory…</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
|
||||
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
|
||||
<li><a href="#from-new-yorker">From New Yorker</a></li>
|
||||
<li><a href="#from-vox">From Vox</a></li>
|
||||
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
|
||||
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
|
||||
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
|
||||
<li><a href="#from-ars-technica">From Ars Technica</a></li>
|
||||
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Affirmative Action and the Supreme Court’s Troubled Treatment of Asian Americans</strong> - Students for Fair Admissions is one of only a few Supreme Court cases about the rights of Asian Americans. But what will it achieve on their behalf? - <a href="https://www.newyorker.com/news/our-columnists/affirmative-action-and-the-supreme-courts-troubled-treatment-of-asian-americans">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chuck Schumer’s Final Call</strong> - The Senate Majority Leader navigated one of the most sweeping legislative sessions in memory—why haven’t voters seemed to notice? - <a href="https://www.newyorker.com/news/the-political-scene/chuck-schumers-final-call">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Republican Insiders Think the G.O.P. Is Poised for a Blowout</strong> - The consensus among pollsters and consultants is this Tuesday’s election will be a “bloodbath” for the Democratic Party. - <a href="https://www.newyorker.com/news/the-political-scene/why-republican-insiders-think-the-gop-is-poised-for-a-blowout">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Unlikely Victory of John Fetterman</strong> - In the early hours of the morning, as it became clear that Fetterman had won his crucial Senate race, his watch party turned from tension to celebration. - <a href="https://www.newyorker.com/news/news-desk/the-unlikely-victory-of-john-fetterman">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Midterm Elections Deliver a Stunning Return to the Status Quo</strong> - The red wave never materialized, Trump’s handpicked candidates underperformed, some new faces emerged—but the country appears as evenly divided as ever. - <a href="https://www.newyorker.com/news/the-political-scene/the-midterm-elections-deliver-a-stunning-return-to-the-status-quo">link</a></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
|
||||
<ul>
|
||||
<li><strong>South Dakota voters decide to extend Medicaid coverage to 45,000 people</strong> -
|
||||
<figure>
|
||||
<img alt="" src="https://cdn.vox-cdn.com/thumbor/8-wCy1vPkHSNxNwKzhcXtU0csnM=/254x0:1694x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71604565/medicaid_SD.0.jpg"/>
|
||||
<figcaption>
|
||||
Getty Images, Vox
|
||||
</figcaption>
|
||||
</figure>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Yet another Medicaid expansion ballot measure passed in a Republican state.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lhfeK4">
|
||||
Medicaid expansion has extended its extraordinary winning streak at the ballot box in <a href="https://www.vox.com/health-care/2022/9/30/23377495/medicaid-expansion-states-south-dakota-ballot-initiative">South Dakota</a>.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V4g9aT">
|
||||
Six times before this Election Day, voters in a state had weighed in directly on whether to <a href="https://www.vox.com/ad/18307627/medicaid-expansion-states-income-requirements">expand Medicaid</a> under the Affordable Care Act and make more low-income adults eligible for free public health coverage. Six times, the ballot measure had passed.
|
||||
</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZpX9FD">
|
||||
That undefeated streak has now reached seven wins with the passage of South Dakota Constitutional Amendment D on Tuesday, according to <a href="https://electionresults.sd.gov/resultsSW.aspx?type=BQ&map=CTY">the election results from the South Dakota secretary of state’s office</a>.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J5cqdH">
|
||||
Voters there approved <a href="https://ballotpedia.org/South_Dakota_Constitutional_Amendment_D,_Medicaid_Expansion_Initiative_(2022)">a constitutional amendment</a> that would extend Medicaid eligibility under the Affordable Care Act. Anybody making less than 133 percent of the federal poverty level (about $18,000 for an individual or $36,900 for a family of four) would qualify for Medicaid coverage.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wxYJEH">
|
||||
Right now, 5 percent of South Dakotans are uninsured. Childless adults of working age can not qualify for coverage at all. Pregnant women, children, and the elderly can currently receive Medicaid benefits, but working parents must have a very low income — less than 63 percent of the federal poverty level, about $17,500 for a family of four — to enroll.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d5YZRO">
|
||||
An estimated <a href="https://www.healthinsurance.org/medicaid/south-dakota/">45,000 South Dakotans</a> would be covered by the expansion, adding to <a href="https://www.kff.org/health-reform/state-indicator/medicaid-expansion-enrollment/?currentTimeframe=0&sortModel=%7B%22colId%22:%22Location%22,%22sort%22:%22asc%22%7D">20.4 million low-income Americans nationwide</a> already insured by the Medicaid expansion since the program took full effect in 2014. Many of those who would qualify for Medicaid in South Dakota — <a href="https://www.startribune.com/american-indians-in-south-dakota-slip-through-cracks-of-health-overhaul/278603381/">about 14,000</a> — are American Indians currently ineligible for coverage.
|
||||
</p>
|
||||
<div class="c-float-right">
|
||||
<div id="ablWTz">
|
||||
<div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
</div>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bgGrdv">
|
||||
Initially, the Affordable Care Act was meant to expand Medicaid coverage to low-income adults nationwide. The law offered a good deal: Expand eligibility and receive a generous federal funding match, 90 percent of the cost in perpetuity. But a 2012 Supreme Court decision made Medicaid expansion optional for states, and a dozen states still have not accepted the expansion a full decade later, leaving <a href="https://www.kff.org/medicaid/issue-brief/the-coverage-gap-uninsured-poor-adults-in-states-that-do-not-expand-medicaid/">4 million people without Medicaid coverage</a> who would otherwise be eligible.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ettKeD">
|
||||
In the face of that obstruction from Republican state officials, health care advocates have taken the issue directly to voters in largely Republican states, with remarkable success.
|
||||
</p>
|
||||
<div class="c-float-right">
|
||||
<div id="Rcxd7w">
|
||||
<div>
|
||||
|
||||
</div>
|
||||
</div>
|
||||
</div>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BnrySd">
|
||||
Across the six states that had already expanded Medicaid <a href="https://www.kff.org/medicaid/issue-brief/status-of-state-medicaid-expansion-decisions-interactive-map/">through a ballot measure</a> — Idaho, Maine, Missouri, Nebraska, Oklahoma, and Utah — an estimated 811,000 people have either enrolled or become eligible for Medicaid coverage. It’s a new frontier for expanding access to health insurance in America. Before the election, I asked Paul Starr, a Princeton University sociologist and the preeminent historian of the American health system, whether there was any precedent for direct democracy leading to such significant coverage expansions.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fplJeJ">
|
||||
“The history of health insurance protection until the Supreme Court’s decision on the ACA in 2012 was almost entirely a history of legislation and administrative decisions,” he told me. “Ballot measures weren’t very significant.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sz4qXI">
|
||||
But ballot initiatives have become, in the last few years, almost exclusively the path for Medicaid expansion to keep advancing. In the first few years after the Supreme Court’s decision, a number of Republican state leaders decided to adopt Medicaid expansion on their own, driven by the financial benefits and lobbying from local health care groups. The Obama administration accepted waivers — including one from future Vice President Mike Pence, then governor of Indiana — to tweak the program to make it more amenable to these GOP politicians.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="alyhKy">
|
||||
But by 2017, with Donald Trump entering the White House, the prospects for future action by Republican governors and legislatures looked grim. So the Fairness Project, an offshoot of an SEIU health care workers union in California that was supporting minimum wage ballot initiatives at the time, started coordinating with local organizers to put Medicaid expansion directly on the ballot.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZsHCZz">
|
||||
“Direct democracy has been a path for important change and also a path of last resort,” Kelly Hall, a former Obama administration health official who is now the executive director of the Fairness Project, said. “Expanding Medicaid anywhere helps protect it everywhere.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zchvgr">
|
||||
The last few years have been a revelation of Medicaid’s political potency. Concerns about ending the expansion and cutting Medicaid spending helped doom the Republican plans to repeal and replace the ACA. And these six expansion ballot initiatives have all passed since 2017, with South Dakota becoming the seventh.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dFuyXE">
|
||||
Hall said the campaign’s goal has been “helping to place Medicaid alongside the other third-rail public programs like Medicare and Social Security.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jpH5k0">
|
||||
“Medicaid has a much wider base of support than many people appreciate,” Starr told me. “It’s not just the poor who benefit. It’s also people with disabilities and seniors, plus their families and the providers that benefit from Medicaid payment.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LahaoE">
|
||||
GOP leaders have still tried — unsuccessfully to date — to stop or subvert these ballot initiatives, first in <a href="https://www.vox.com/policy-and-politics/2019/2/11/18220721/utah-medicaid-expansion-prop-3-sb96">Utah</a> and <a href="https://www.vox.com/policy-and-politics/22440101/missouri-medicaid-expansion-joe-biden">Missouri</a>, and also in South Dakota. For the primary election in June, the state legislature put up a ballot measure that would have required a 60 percent supermajority for any future ballot initiatives to be adopted, with the intent of making it harder for the Medicaid expansion measure to pass. But <a href="https://ccf.georgetown.edu/2022/06/24/south-dakotas-journey-to-medicaid-expansion-an-update/">it was rejected</a> by two-thirds of South Dakota primary voters.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yuyWLT">
|
||||
Why does Medicaid expansion keep finding success with red-state voters, if not their elected representatives? Hall pointed to three successful messages: hearing from neighbors who will benefit, bringing federal tax dollars back to the state, and protecting the solvency of rural hospitals and health clinics. <a href="https://www.youtube.com/watch?v=eBuC6-HuzPE">One of the ads</a> that ran in South Dakota featured a farmer who says he wants to keep his family farm running but can’t afford health care right now.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TffLVM">
|
||||
To date, Medicaid expansion ballot initiatives have been an unqualified success. But their usefulness might soon be running out. Only about half of states allow citizen-initiated ballot measures and, of the 12 states that haven’t expanded Medicaid, only four of them permit such initiatives: South Dakota — which has now voted on it — plus Florida, Mississippi, and Wyoming.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5im0Hi">
|
||||
Florida is the second biggest state, after Texas, that is still refusing Medicaid expansion. Those two states are home to <a href="https://www.kff.org/medicaid/issue-brief/the-coverage-gap-uninsured-poor-adults-in-states-that-do-not-expand-medicaid/">more than half of the 2.2 million people nationwide</a> who have been left without a viable option for coverage because their state has not expanded Medicaid. But while ballot initiatives are permitted there, they require a 60 percent supermajority and the state legislature has shown <a href="https://www.theguardian.com/us-news/2020/aug/06/republicans-florida-amendment-4-voting-rights">a willingness to undermine ballot measures after their passage</a>.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4k6KMj">
|
||||
The entire Mississippi ballot initiative process, meanwhile, was <a href="https://www.mississippifreepress.org/12260/in-blow-to-voters-mississippi-supreme-court-kills-medical-marijuana-and-all-ballot-initiatives/">upended by a state court decision in 2021</a>; advocates are working to restore the rights of citizens to collect signatures and put issues directly to voters. In Wyoming, there is some hope that the legislature and governor <a href="https://cowboystatedaily.com/2022/08/30/wyoming-legislature-discussing-medicaid-expansion-again/">may yet get on board with Medicaid expansion</a> as the state faces budget woes.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fF5Wkx">
|
||||
So while ballot measures could still make more gains in expanding Medicaid coverage, expansion advocates are running out of opportunities. Texas, for example, is one of the states that does not allow citizen-sponsored ballot initiatives. Neither do Georgia and North Carolina, the next biggest states after Florida not to expand Medicaid.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3mrgEQ">
|
||||
“We’re pretty close to working ourselves out of a job on this topic,” Hall said.
|
||||
</p></li>
|
||||
<li><strong>The 2022 midterm elections, explained</strong> -
|
||||
<figure>
|
||||
<img alt="" src="https://cdn.vox-cdn.com/thumbor/VX863FWJfP3q0sJhQWeFfMbbdY0=/0x142:2995x2388/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71431201/GettyImages_1350833520c.0.jpg"/>
|
||||
<figcaption>
|
||||
A person votes in Brooklyn, New York, in November 2021. | Michael M. Santiago/Getty Images
|
||||
</figcaption>
|
||||
</figure>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Weoy5W">
|
||||
The 2022 midterms are coming up on November 8, when voters across the US will decide the makeup of Congress, determine who will hold key offices in their states and cities, and weigh in on policies directly via ballot measures.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xdmmg5">
|
||||
Democrats currently have narrow majorities in both chambers, and because the same party holds the White House, conditions are ideal for them to pass bills President Joe Biden will sign. But forecasts suggest Democrats are likely to lose control of the House and keep the Senate this fall — though many key races are so close that anything is possible.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Hzzh93">
|
||||
Beyond Washington, governors, secretaries of state, and attorneys general, along with members of the legislature, are up for election in dozens of states. The winners of those contests will affect state policies on issues as varied as abortion, voting rights, and Covid-19.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KXHezI">
|
||||
Vox has been digging into the stakes of individual races and the entire country and will continue to through and even after Election Day. If you’re just starting to follow the elections, you can get a better understanding of what’s on the line <a href="https://www.vox.com/policy-and-politics/2022/9/12/23344632/midterms-2022-elections-key-house-senate-races-control-congress">here</a>, and if you’re trying to figure out what you need to do to vote, <a href="https://www.vox.com/even-better/23363748/voting-guide-registration-polling-place-voter-suppression">start here</a>.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RslRk5">
|
||||
Do you have something you want explained that you don’t see on this page? Ask a Vox reporter your questions about Congress <a href="https://docs.google.com/forms/d/e/1FAIpQLSf6isuraAwbdnBBVVKorqU-b6TdYQFuHmQKqcrW5TC-N1Y4bg/viewform">here</a>, about what’s going on in the states <a href="http://vox.com/ask-nicole-narea.">here</a>, and about the politics of the midterms <a href="https://docs.google.com/forms/d/e/1FAIpQLSfgKliYTFIvitGbPSxGzMyiB1PnfUWBq_Ef81sdv0y5-R8qGw/viewform">here</a>.
|
||||
</p></li>
|
||||
<li><strong>2 winners and 3 losers from the midterm results so far</strong> -
|
||||
<figure>
|
||||
<img alt="An illustration on a red background with blue shapes shows Florida Gov. Ron DeSantis with his fist raised and House Minority Leader Kevin McCarthy with a sad expression. " src="https://cdn.vox-cdn.com/thumbor/HpsLuCIme6hgWhOsm3sgwTNb18M=/0x0:1440x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71604250/winners_losers_midterms_v2.0.jpg"/>
|
||||
<figcaption>
|
||||
Dion Lee/Vox
|
||||
</figcaption>
|
||||
</figure>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Big races and congressional majorities haven’t been called, but we have a few clear lessons.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EYTTPl">
|
||||
The votes are still being tallied in the 2022 midterms. Many key races haven’t been called as of early Wednesday morning, and we don’t know who will control either chamber of Congress. That means we also don’t know the answer to <a href="https://www.vox.com/policy-and-politics/2022/11/7/23441115/midterm-election-questions-answers-results">many of the big questions</a> these midterms presented.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9Oq3UA">
|
||||
Those questions may take weeks to resolve. But before <a href="https://www.bangordailynews.com/2022/09/01/politics/alaskas-foray-into-ranked-choice-voting-xoasq1i29i/">ranked-choice tabulations</a> occur in Maine and Alaska, let alone a potential Senate runoff in Georgia, there are a few clear lessons to be taken from the races called so far.
|
||||
</p>
|
||||
<h3 id="lscWuA">
|
||||
Winner: Ron DeSantis
|
||||
</h3>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NeVBM3">
|
||||
Ron DeSantis may have had the best night of any Republican in the country. The Florida governor won what was once a swing state by a margin of nearly 20 points, and won base Democratic counties — or at least what were once base Democratic counties — like Palm Beach and <a href="https://nymag.com/intelligencer/2020/11/republican-socialism-attacks-haunt-democrats-in-florida.html">Miami Dade</a>. DeSantis built on Republican gains among Hispanic voters in Florida in 2020, including among Cuban Americans and Venezuelan Americans in metro Miami, and Puerto Ricans in metro Orlando. He also ended up carrying 62 of Florida’s 67 counties.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4kBFrb">
|
||||
The huge win positions DeSantis for a <a href="https://www.vox.com/policy-and-politics/23448695/trump-2024-republicans-desantis-abbott-scott-sununu">potential 2024 presidential campaign</a>, and it makes him the symbol of Republican success on a night that was underwhelming for the rest of the GOP. Florida was the one of the few states where expectations for a “red wave” came to pass.
|
||||
</p>
|
||||
<h3 id="ux9Y9X">
|
||||
Loser: Waves
|
||||
</h3>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A51ubI">
|
||||
Beyond Florida, the red wave didn’t wash ashore on Tuesday.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="unsjDK">
|
||||
Given all the hype of a big night for Republicans in the days and weeks before Election Day, it was a disappointing evening for them. The expectation that Republicans would not just win toss-up races, but carry races where they were underdogs, did not come to pass. <a href="https://www.axios.com/2022/11/08/republican-midterms-credit-mccarthy-mcconnell-scott">The frantic fight to take credit</a> for the wins on Tuesday afternoon was already turning into a frenetic effort to avoid taking the blame on Wednesday morning.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TNL6Ez">
|
||||
The GOP may still end up capturing control of both chambers of Congress when all the votes are counted, but it would not be the type of win that some Republicans expected even in the hours before polls closed on Tuesday. Instead, it would be by narrow margins that will prove far short of GOP dreams of winning historic majorities in the House and picking up enough seats in the Senate to set themselves up for a filibuster-proof supermajority after 2024. And wins at this point will represent incremental gains for Republicans who were only able to grasp the lowest-hanging fruit.
|
||||
</p>
|
||||
<h3 id="Q3fLmg">
|
||||
Loser: Donald Trump
|
||||
</h3>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LfXOfC">
|
||||
Former President Donald Trump’s candidates had a lackluster night on Tuesday, and there’s potential for this to turn into an embarrassing election season for him as more races are called.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rPCoNE">
|
||||
In Georgia, his handpicked Senate candidate <a href="https://www.vox.com/policy-and-politics/23412672/herschel-walker-georgia-football-jeff-pearlman">Herschel Walker</a> ran far behind the rest of the GOP ticket. While Brian Kemp and Brad Raffensperger, the incumbent governor and secretary of state whom Trump backed unsuccessful primary challenges against, won easily, Walker lagged behind them. With <a href="https://www.nytimes.com/interactive/2022/11/08/us/elections/results-georgia.html">over 95 percent of the vote reporting</a>, the former NFL player was just behind incumbent Sen. Raphael Warnock.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y2TLVP">
|
||||
In Pennsylvania, Trump-endorsed Dr. Mehmet <a href="https://www.vox.com/policy-and-politics/23425073/midterm-elections-2022-pennsylvania-senate-fetterman-oz">Oz lost a Senate seat</a> to the state’s Lt. Gov. John Fetterman. Oz’s primary win over hedge fund mogul Dave McCormick and conservative activist Kathy Barnette was attributed to Trump’s endorsement, and he trailed Fetterman for most of the general election. In Michigan, Trump endorsed a former official in his administration, John Gibbs, against incumbent Republican Rep. Peter Meijer, who voted for impeachment. Gibbs won the primary, but lost on Tuesday night.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qbLI1k">
|
||||
There were some wins for Trump: J.D. Vance <a href="https://www.vox.com/policy-and-politics/2022/10/21/23415211/ohio-senate-jd-vance-tim-ryan-midterm-elections">won handily</a> in the Ohio Senate race, for example<strong>,</strong> after Trump picked him in the primary and rallied for him throughout the general. But several races remain to be called where Trump put his finger on the scale (like Arizona Senate candidate Blake Masters and Arizona governor candidate Kari Lake). All of that will call into question Trump’s political acumen as his favored candidates underperformed, while a top 2024 rival — DeSantis — had a successful night.
|
||||
</p>
|
||||
<h3 id="V42xLe">
|
||||
Winner: Baseline partisanship
|
||||
</h3>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gVJVXQ">
|
||||
The incumbent Republican governor won handily in Oklahoma on Tuesday night while the incumbent Democrat notched a victory in New York. The quick, clear results were mildly surprising, based on public polls that had Democrat Joy Hofmeister ahead of Gov. Kevin Stitt in Oklahoma and Gov. Kathy Hochul neck and neck with GOP challenger Lee Zeldin in New York.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LbzgT0">
|
||||
But it turned out Democrats in Democratic states ended up voting for Democrats, while Republicans in Republican states voted for Republicans.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X3yOlg">
|
||||
This didn’t hold everywhere. Incumbent Democrat Laura Kelly was in a strong position in the Kansas governor’s race early Wednesday, while Republicans seemed well placed in open congressional seats in New York. But more often than not, voters voted how one would expect them to. Republicans couldn’t pull off upsets they were optimistic about in Democratic-leaning congressional districts in Virginia and Rhode Island, and MAGA candidates couldn’t win statewide in states like Minnesota and New Hampshire, where Trump had never won in a general election. The result was a night that resembled the same political terrain fought over in 2020, with candidates winning narrowly in swing states after hard-fought and expensive races.
|
||||
</p>
|
||||
<h3 id="ahDggx">
|
||||
Loser: Kevin McCarthy
|
||||
</h3>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xR51Ni">
|
||||
House Republicans are still favored to regain the majority in Congress, four years after losing it in the 2018 midterms, and current House Minority Leader Kevin McCarthy is still favored to be the speaker of the House if they do. He sounded upbeat in remarks early Wednesday. “You are out late, but when you wake up tomorrow, we will be the majority and [House Speaker] Nancy Pelosi will be in the minority,” he said.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bjVXRK">
|
||||
But if McCarthy’s hair was not already uniformly silver, it would be turning gray after this Election Day.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="saFQoo">
|
||||
If the GOP prevails, the House Republican leader will have to manage a far smaller majority than he had hoped. One member of Congress <a href="https://nymag.com/intelligencer/2022/10/2022-midterms-kevin-mccarthy-is-the-man-in-the-maga-middle.html">said</a> earlier in the fall that McCarthy would need a big majority — one greater than 20 seats — to be guaranteed to win the speaker’s gavel in 2023.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qCwyye">
|
||||
Projections early Wednesday morning left it unclear he will hit that total, and the GOP will certainly fall short of the 60 seats that McCarthy boasted were in play just a year ago after Glenn Youngkin’s win in <a href="https://thehill.com/homenews/house/579895-gop-leader-says-republicans-could-flip-60-seats-next-year/">the Virginia governor’s race</a>. That leaves him likely to manage a slender majority, a task that drove the last two Republican speakers, John Boehner and Paul Ryan, out of politics, as fractious right-wingers constantly rebelled against them.
|
||||
</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL auction to be held on December 23 in Kochi</strong> - Istanbul, Bengaluru, New Delhi, Mumbai and Hyderabad were also in contention to host the mini auction ahead of the 2023 season</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bullish Tamil Nadu looks sharp for the upcoming Vijay Hazare Trophy</strong> - It’s recent outing against the visiting Bangladesh XI will hold it in good stead, says skipper Indrajith</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Petronia, Rodrigo and Django catch the eye</strong> -</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mahendra Kumar Sharma no more</strong> -</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Griner sent to Russian penal colony to serve sentence</strong> - A Russian court rejected an appeal of Brittney Griner’s nine-year sentence last month</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UDF will oppose LDF Ordinance to remove Kerala Governor as Chancellor: K. Sudhakaran</strong> - The Governor should be ready to legally implement his powers and rights, and the State government should ensure that it does not encroach upon his rights, he says</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Government stipulations for new varsities may inhibit their growth</strong> - Redeployment of staff as directed by the govt. fraught with difficulties</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intellectuals pen open letter to Modi</strong> - Demands implementation of promises mentioned in Reorganisation Act</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Forest routes to Sabarimala set for full-scale opening after pandemic</strong> - The Forest department expects the path to witness heavy rush right from the season’s beginning and has kick-started works to restore the path</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Risk of blindness double among diabetics in urbanised States, says study</strong> - In India, about 30 lakh diabetics, aged over 40, are in danger of losing their sight, say researchers in an article published in The Lancet</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Italy earthquake felt in several countries</strong> - A 5.5-magnitude earthquake off Italy’s east coast is felt in Rome and parts of the Balkans.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>France calls time on anti-jihadist Operation Barkhane in Sahel</strong> - The Ukraine war shows France’s military might be better directed elsewhere than a thankless campaign.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>2023 Rugby World Cup: French prosecutors search headquarters</strong> - Financial prosecutors search the headquarters of France’s 2023 Rugby World Cup organisers.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ancient Rome: Stunningly preserved bronze statues found in Italy</strong> - The discovery of 24 statues thought to be around 2,300 years old may “rewrite history”, an expert says.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Norway princess quits royal duties for alternative medicine</strong> - Princess Märtha Louise and her fiancé, shaman Durek Verrett, have attracted criticism in Norway.</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Patches for 6 zero-days under active exploit are now available from Microsoft</strong> - Exchange, Windows, and a bunch of other Microsoft software all affected. - <a href="https://arstechnica.com/?p=1896179">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ars OpenForum & Commenting System are getting a big upgrade</strong> - Comments and the OpenForum will be down from 1 am ET until Wednesday afternoon. - <a href="https://arstechnica.com/?p=1896147">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Elizabeth Holmes loses bid for new trial despite bizarre visit from key witness</strong> - Holmes is expected to appeal her conviction. - <a href="https://arstechnica.com/?p=1896155">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Redditor discovers legendary 1956 computer in grandparents’ basement</strong> - The 1956 LGP-30 computer, subject of hacker lore, is one of only 45 made in Europe. - <a href="https://arstechnica.com/?p=1895927">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>US renewable growth puts them on par with nuclear</strong> - Coal, wind, and solar all went up as hydro took a dive. - <a href="https://arstechnica.com/?p=1896112">link</a></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
|
||||
<ul>
|
||||
<li><strong>Voting is like doing a group project in school</strong> - <!-- SC_OFF -->
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
I did my part, but I’m worried the rest of you are going to fuck this up
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MisterB78"> /u/MisterB78 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/yq7gzw/voting_is_like_doing_a_group_project_in_school/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/yq7gzw/voting_is_like_doing_a_group_project_in_school/">[comments]</a></span></p></li>
|
||||
<li><strong>As a butcher is shooing away a dog from his shop, he sees a $25 bill and a note in his mouth, reading: “10 pork chops, please.”</strong> - <!-- SC_OFF -->
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Amazed, he takes the money, puts a bag of pork chops in the dog’s mouth, and quickly closes the shop.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
He follows the dog and watches him wait for a green light, look both ways, and trot across the road to a bus stop. The dog checks the timetable and sits on the bench. When a bus arrives, he walks around to the front and looks at the number, then boards the bus. The butcher follows, dumbstruck. As the bus travels out into the suburbs, the dog takes in the scenery. After a while he stands on his back paws to push the “stop” bell, then the butcher follows him off. The dog runs up to a house and drops his bag on the step. He goes back down the path, takes a big run, and throws himself -WHAP!- against the door. He does this again and again. No answer. So he jumps on a wall, walks around the garden, beats his head against a window, jumps off, and waits at the front door. A big guy opens it and starts cursing and shouting at the dog.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The butcher runs up and screams at the guy: “What in hell are you doing? This dog’s a genius!” The owner responds, “Genius, my ass… It’s the second time this week he’s forgotten his keys!”
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/regwregarvfse"> /u/regwregarvfse </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ypuey0/as_a_butcher_is_shooing_away_a_dog_from_his_shop/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ypuey0/as_a_butcher_is_shooing_away_a_dog_from_his_shop/">[comments]</a></span></p></li>
|
||||
<li><strong>The billionaire and the mermaid whisperer</strong> - <!-- SC_OFF -->
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
A billionaire is sailing his yacht past a lighthouse, and he sees the elderly lighthouse keeper out on the rocks at the base of the lighthouse, getting a blowjob from a mermaid - the top half was a stunning, curvy redhead, and the bottom half was a tiger shark. As he watches, the pair finish the act and the mermaid swims away.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The billionaire is stunned, and anchors his yacht there to see if it happens again. Sure enough, the next afternoon, the lighthouse keeper comes out, blows on a conch shell, and a gorgeous blonde merman with the bottom half of a swordfish swims up, and thoroughly satisfies him.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The next day this happens again! This time he blows on a different conch and the mermaid is a petite brunette with the bottom half of a seahorse.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The billionaire decides he must have this, and every night for the next two weeks, he scours the local bars to find the lighthouse keeper. He finally runs him down at a fisherman’s bar and sits down next to him.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“I’ll give you a million dollars if you tell me how you get those mermaids to come up to you. Only the female ones, though, I’m prejudiced.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“No,” says the lighthouse keeper “it’s too difficult and dangerous, and I don’t want the liability”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Two million dollars and a waiver” says the billionaire.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Fine” says the lighthouse keeper, and they handle the paperwork.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Okay, here’s what you do. You learn to hold your breath for five minutes, and go to the rock pool behind the lighthouse. Stay underwater for five minutes without any help, and a mermaid will be impressed and swim up and give you a conch. And that’s how you get Seahorse Julie.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Too hard!” says the billionaire. “What else do you have?”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
" Get really good at swimming in the open ocean. At exactly midnight, leave from the lighthouse shore, and swim due east for exactly four miles, without your GPS watch, and a mermaid will be impressed and give you a conch. That’s how you get Tiger shark Alice. "
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
" Too complicated!" fumes the billionaire, “Try again!”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Fine, here’s an easy but gross one” says the lighthouse keeper. “Go to the chicken farm three miles north of here and ask for their sickliest chicken. Pluck it, and then soak it in their sewage runoff for a day. Then grind it up into a smoothie, let it ferment for two days, and then go onto the bow of your yacht and chug it at high noon. That’s how…”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“At last!” shouts the billionaire, and rushes off to get the chicken. Three days later, he’s standing on the pointy end of his yacht, holding his nose and drinking a greyish pink smoothie.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
And that’s how he got Salmon Ella.
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/SopwithTurtle"> /u/SopwithTurtle </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/yq1qlv/the_billionaire_and_the_mermaid_whisperer/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/yq1qlv/the_billionaire_and_the_mermaid_whisperer/">[comments]</a></span></p></li>
|
||||
<li><strong>Voting is a lot like driving</strong> - <!-- SC_OFF -->
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
To go backwards, choose “R”.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
To go forward, choose “D”.
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/hearsdemons"> /u/hearsdemons </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ypp8pf/voting_is_a_lot_like_driving/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ypp8pf/voting_is_a_lot_like_driving/">[comments]</a></span></p></li>
|
||||
<li><strong>What do you call a flying nun?</strong> - <!-- SC_OFF -->
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
A bird? A plane?
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Nope, nun of the above
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/itsisdd69"> /u/itsisdd69 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/yqb5y8/what_do_you_call_a_flying_nun/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/yqb5y8/what_do_you_call_a_flying_nun/">[comments]</a></span></p></li>
|
||||
</ul>
|
||||
|
||||
|
||||
<script>AOS.init();</script></body></html>
|
||||
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Reference in New Issue