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 <h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-preprints">From Preprints</a></li>
 <li><a href="#from-clinical-trials">From Clinical Trials</a></li>
 <li><a href="#from-pubmed">From PubMed</a></li>
 <li><a href="#from-patent-search">From Patent Search</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
 <ul>
 <li><strong>Conceptual flexibility and the meaning of Covid-19: evidence from the first Italian lockdown</strong> -
 <div>
 Several studies highlighted the flexible character of our conceptual system. However, less is known about the construction of meaning and the impact of novel concepts on the structuring of our conceptual space. We addressed these questions by collecting free listing data from Italian participants on a newly–and yet nowadays critical–introduced concept, i.e., Covid-19, during the first Italian lockdown. We also collected data for other five illness-related concepts. Our results show that Covid-19’s representation is mostly couched in the emotional sphere, predominantly evoking fear—linked to both possible health-related concerns and social-emotional ones. In contrast with initial public debates participants did not assimilate Covid-19 neither completely to severe illnesses (e.g., tumor) nor completely to mild illnesses (e.g., flu). Moreover, we also found that Covid-19 has shaped conceptual relations of other concepts in the illness domain, making certain features and associations more salient (e.g., flu-fear; disease-mask). Overall, our results show for the first time how a novel, real concept molds existing conceptual relations, testifying the malleability of our conceptual system.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://psyarxiv.com/4ndb8/" target="_blank">Conceptual flexibility and the meaning of Covid-19: evidence from the first Italian lockdown</a>
 </div></li>
 <li><strong>Pandemics Initially Spread Among People of High (not Low) Social Status: Evidence from COVID-19 and the Spanish Flu</strong> -
 <div>
 According to a staple in the social sciences, pandemics particularly spread among people of lower social status. Challenging this staple, we hypothesize that it holds true in later phases of pandemics only. In the initial phases, by contrast, people of higher social status should be at the center of the spread. To test this hypothesis, we conducted two studies. In Study 1, we analyzed region-level COVID-19 infection data from 3,132 U.S. regions, 299 English regions, and 400 German regions. In Study 2, we analyzed historical data from 1,159,920 U.S. residents who witnessed the 1918/1919 Spanish Flu pandemic. Both studies supported our hypothesis in full. During the initial phases of both pandemics, the virus spread more rapidly among people of higher social status. In later phases, that effect consistently reversed, rendering people of lower social status the primarily exposed. Our results provide novel insights into the center of the spread during the critical initial phases of pandemics.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://psyarxiv.com/vdqpa/" target="_blank">Pandemics Initially Spread Among People of High (not Low) Social Status: Evidence from COVID-19 and the Spanish Flu</a>
 </div></li>
 <li><strong>Microsecond simulation unravel the structural dynamics of SARS-CoV-2 Spike-C-terminal cytoplasmic tail (residues 1242-1273)</strong> -
 <div>
 Spike protein of human coronaviruses has been a vital drug and vaccine target. The multifunctionality of this protein including host receptor binding and apoptosis has been proved in several coronaviruses. It also interacts with other viral proteins such as membrane (M) protein through its C-terminal domain. The specific dibasic motif signal present in cytosolic region at C-terminal of spike protein helps it to localize within the endoplasmic reticulum (ER). However, the structural conformation of cytosolic region is not known in SARS-CoV-2 using which it interacts with other proteins and transporting vesicles. Therefore, we have demonstrated the conformation of cytosolic region and its dynamics through computer simulations up to microsecond timescale using OPLS and CHARMM forcefields. The simulations have revealed the unstructured conformation of cytosolic region (residues 1242-1273). Also, in temperature dependent replica-exchange molecular dynamics simulations it has shown to form secondary structures. We believe that our findings will surely help us understand the structure-function relationship of the spike protein's cytosolic region.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.11.426227v1" target="_blank">Microsecond simulation unravel the structural dynamics of SARS-CoV-2 Spike-C-terminal cytoplasmic tail (residues 1242-1273)</a>
 </div></li>
 <li><strong>Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment</strong> -
 <div>
 Motivation: The SARS-CoV-2 variants emerging from South Africa (501.V2) and the UK (B.1.1.7) necessitate rapid assessment of the effects of the corresponding amino acid substitutions in the spike (S) receptor-binding domain (RBD) of the variants on the interactions with the human ACE2 receptor and monoclonal antibodies (mAbs) reported earlier to neutralize the spike. Results: Molecular modeling and simulations reveal that N501Y, shared by both variants, increases ACE2 binding affinity, and may impact the collective dynamics of the ACE2-RBD complex, occupying a central hinge site that modulates the overall dynamics of the complex. In contrast, the substitutions K417N and E484K in the South African variant 501.V2 would reduce the ACE2-binding affinity by abolishing two interfacial salt bridges that facilitate RBD binding to ACE2, K417(S)-D30(ACE2) and E484 (S)-K31(ACE2). These two mutations may thus be more than compensating the attractive effect induced by N501Y, overall resulting in an ACE2-binding affinity comparable to that of the wildtype RBD. Further analysis of the impact of these mutations on the interactions with mAbs targeting the spike indicate that the substitutions K417N and E484K may also abolish the salt bridges between the spike and selected mAbs, such as REGN10933, BD23, H11_H4, and C105, thus reducing the binding affinity and effectiveness of these mAbs.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.10.426143v1" target="_blank">Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment</a>
 </div></li>
 <li><strong>Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination</strong> -
 <div>
 The severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) has emerged as the infectious agent causing the pandemic coronavirus disease 2019 (COVID-19) with dramatic consequences for global human health and economics. Previously, we reached clinical evaluation with our vector vaccine based on vaccinia virus MVA against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes an infection in humans similar to SARS and COVID-19. Here, we describe the construction and preclinical characterization of a recombinant MVA expressing full-length SARS-CoV-2 spike (S) protein (MVA-SARS-2-S). Genetic stability and growth characteristics of MVA-SARS-2-S, plus its robust synthesis of S antigen, make it a suitable candidate vaccine for industrial scale production. Vaccinated mice produced S antigen-specific CD8+ T cells and serum antibodies binding to S glycoprotein that neutralized SARS-CoV 2. Prime-boost vaccination with MVA-SARS-2-S protected mice sensitized with a human ACE2-expressing adenovirus from SARS-CoV-2 infection. MVA-SARS-2-S is currently being investigated in a phase I clinical trial as aspirant for developing a safe and efficacious vaccine against COVID-19.
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 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.09.426032v1" target="_blank">Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination</a>
 </div></li>
 <li><strong>Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques</strong> -
 <div>
 Intramuscular vaccination with ChAdOx1 nCoV-19/AZD1222 protected rhesus macaques against pneumonia but did not reduce shedding of SARS-CoV-2. Here we investigate whether intranasally administered ChAdOx1 nCoV-19 reduces shedding, using a SARS-CoV-2 virus with the D614G mutation in the spike protein. Viral load in swabs obtained from intranasally vaccinated hamsters was significantly decreased compared to controls and no viral RNA or infectious virus was found in lung tissue, both in a direct challenge and a transmission model. Intranasal vaccination of rhesus macaques resulted in reduced shedding and a reduction in viral load in bronchoalveolar lavage and lower respiratory tract tissue. In conclusion, intranasal vaccination reduced shedding in two different SARS-CoV-2 animal models, justifying further investigation as a potential vaccination route for COVID-19 vaccines.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.09.426058v1" target="_blank">Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques</a>
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 <li><strong>COVID-19 Severity Is Associated with Differential Antibody Fc-mediated Innate Immune Functions</strong> -
 <div>
 Beyond neutralization, antibodies elicit several innate immune functions including complement deposition (ADCD), phagocytosis (ADCP), and cytotoxicity (ADCC). These functions can be both beneficial (by clearing pathogens) and/or detrimental (by inducing inflammation). We tested the possibility that qualitative differences in SARS-CoV-2 specific antibody-mediated innate immune functions contribute to Coronavirus disease 2019 (COVID-19) severity. We found that antibodies from hospitalized COVID-19 patients elicited higher ADCD but lower ADCP compared to antibodies from non-hospitalized COVID-19 patients. Consistently, higher ADCD was associated with higher systemic inflammation during COVID-19. Our study points to qualitative, differential features of anti-SARS-CoV-2 antibodies as potential contributors to COVID-19 severity.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.11.426209v1" target="_blank">COVID-19 Severity Is Associated with Differential Antibody Fc-mediated Innate Immune Functions</a>
 </div></li>
 <li><strong>Immunogenicity and Protective Efficacy of an Intranasal Live-attenuated Vaccine Against SARS-CoV-2 in Preclinical Animal Models</strong> -
 <div>
 The global deployment of an effective and safe vaccine is currently a public health priority to curtail the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a Newcastle disease virus (NDV)-based intranasal vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy in challenge studies with SARS-CoV-2. The recombinant (r)NDV-S vaccine expressing spike (S) protein of SARS-CoV-2 administrated via intranasal route in mice induced high levels of SARS-CoV-2-specific neutralizing immunoglobulin A (IgA) and IgG2a antibodies and T cell-mediated immunity. Hamsters vaccinated with two doses of vaccine showed complete protection from clinical disease including lung infection, inflammation, and pathological lesions after SARS-CoV-2 challenge. Importantly, a single or double dose of intranasal rNDV-S vaccine completely blocked SARS-CoV-2 shedding in nasal turbinate and lungs within 4 days of vaccine administration in hamsters. Taken together, intranasal administration of rNDV-S has the potential to control infection at the site of inoculation, which should prevent both the clinical disease and transmission to halt the spread of the COVID-19 pandemic.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.08.425974v1" target="_blank">Immunogenicity and Protective Efficacy of an Intranasal Live-attenuated Vaccine Against SARS-CoV-2 in Preclinical Animal Models</a>
 </div></li>
 <li><strong>Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class</strong> -
 <div>
 Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent SARS-CoV-2-neutralizing antibodies yet identified. To provide insight into whether these genetic similarities inform common modes of recognition, we determined structures of the SARS-CoV-2 spike in complex with three VH1-2-derived antibodies: 2-15, 2-43, and H4. All three utilized VH1-2-encoded motifs to recognize the receptor-binding domain (RBD), with heavy chain N53I enhancing binding and light chain tyrosines recognizing F486RBD. Despite these similarities, class members bound both RBD up and down conformations of the spike, with a subset of antibodies utilizing elongated CDRH3s to recognize glycan N343 on a neighboring RBD - a quaternary interaction accommodated by an increase in RBD separation of up to 12 angstrom. The VH1-2-antibody class thus utilizes modular recognition encoded by modular genetic elements to effect potent neutralization, with VH-gene component specifying recognition of RBD and CDRH3 component specifying quaternary interactions.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.11.426218v1" target="_blank">Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class</a>
 </div></li>
 <li><strong>Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain</strong> -
 <div>
 Since the identification of the SARS-CoV-2 virus as the causative agent of the current COVID-19 pandemic, considerable effort has been spent characterizing the interaction between the Spike protein receptor-binding domain (RBD) and the human angiotensin converting enzyme 2 (ACE2) receptor. This has provided a detailed picture of the end point structure of the RBD-ACE2 binding event, but what remains to be elucidated is the conformation and dynamics of the RBD prior to its interaction with ACE2. In this work we utilize molecular dynamics simulations to probe the flexibility and conformational ensemble of the unbound state of the receptor-binding domain from SARS-CoV-2 and SARS-CoV. We have found that the unbound RBD has a localized region of dynamic flexibility in Loop 3 and that mutations identified during the COVID-19 pandemic in Loop 3 do not affect this flexibility. We use a loop-modeling protocol to generate and simulate novel conformations of the CoV2-RBD Loop 3 region that sample conformational space beyond the ACE2 bound crystal structure. This has allowed for the identification of interesting substates of the unbound RBD that are lower energy than the ACE2-bound conformation, and that block key residues along the ACE2 binding interface. These novel unbound substates may represent new targets for therapeutic design.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.08.425965v1" target="_blank">Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain</a>
 </div></li>
 <li><strong>Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2 and heparan sulfate</strong> -
 <div>
 A main clinical parameter of Covid-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor binding domain (RBD) and the S1 subunit (S1) of the spike protein to epithelial cells. In Vero E6 cells, hypoxia reduces the protein levels of ACE2, which might in part explain the observed reduction of the infection rate. However, hypoxia also inhibits the binding of the spike to human lung epithelial cells lacking ACE2 expression, indicating that hypoxia modulates the expression of additional binding partners of SARS-CoV-2. We show that hypoxia also decreases the total cell surface levels of heparan sulfate, a known attachment receptor of SARS-CoV-2, by reducing the expression of syndecan-1 and syndecan3, the main proteoglycans containing heparan sulfate. Our study indicates that hypoxia acts to prevent SARS-CoV-2 infection, suggesting that the hypoxia signaling pathway might offer therapeutic opportunities for the treatment of Covid-19.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.09.426021v1" target="_blank">Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2 and heparan sulfate</a>
 </div></li>
 <li><strong>Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite</strong> -
 <div>
 Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral spike. While RBD-directed antibodies have been extensively studied, far less is known about NTD-directed antibodies. Here we report cryo-EM and crystal structures for seven potent NTD-directed neutralizing antibodies in complex with spike or isolated NTD. These structures defined several antibody classes, with at least one observed in multiple convalescent donors. The structures revealed all seven antibodies to target a common surface, bordered by glycans N17, N74, N122, and N149. This site - formed primarily by a mobile {beta}-hairpin and several flexible loops - was highly electropositive, located at the periphery of the spike, and the largest glycan-free surface of NTD facing away from the viral membrane. Thus, in contrast to neutralizing RBD-directed antibodies that recognize multiple non-overlapping epitopes, potent NTD-directed neutralizing antibodies target a single supersite.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.10.426120v1" target="_blank">Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite</a>
 </div></li>
 <li><strong>The landscape of human brain immune response in patients with severe COVID-19</strong> -
 <div>
 In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between brain tropism, neuroinflammation and host immune response has not been well characterized. We analyzed 68,557 single-nucleus transcriptomes from three brain regions (dorsolateral prefrontal cortex, medulla oblongata and choroid plexus) and identified an increased proportion of stromal cells and monocytes in the choroid plexus of COVID-19 patients. Differential gene expression, pseudo-temporal trajectory and gene regulatory network analyses revealed microglial transcriptome perturbations, mediating a range of biological processes, including cellular activation, mobility and phagocytosis. Quantification of viral spike S1 protein and SARS-CoV-2 transcripts did not support the notion of brain tropism. Overall, our findings suggest extensive neuroinflammation in patients with acute COVID-19.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.08.425999v1" target="_blank">The landscape of human brain immune response in patients with severe COVID-19</a>
 </div></li>
 <li><strong>Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide</strong> -
 <div>
 Cell penetration after recognition of the SARS-CoV-2 virus by the ACE2 receptor, and the fusion of its viral envelope membrane with cellular membranes, are the early steps of infectivity. A region of the Spike protein (S) of the virus, identified as the fusion peptide (FP), is liberated at its N-terminal site by a specific cleavage occurring in concert with the interaction of the receptor binding domain of the Spike. Studies have shown that penetration is enhanced by the required binding of Ca2+ ions to the FPs of corona viruses, but the mechanisms of membrane insertion and destabilization remain unclear. We have predicted the preferred positions of Ca2+ binding to the SARS-CoV-2-FP, the role of Ca2+ ions in mediating peptide-membrane interactions, the preferred mode of insertion of the Ca2+-bound SARS-CoV-2-FP and consequent effects on the lipid bilayer from extensive atomistic molecular dynamics (MD) simulations and trajectory analyses. In a systematic sampling of the interactions of the Ca2+-bound peptide models with lipid membranes SARS-CoV-2-FP penetrated the bilayer and disrupted its organization only in two modes involving different structural domains. In one, the hydrophobic residues F833/I834 from the middle region of the peptide are inserted. In the other, more prevalent mode, the penetration involves residues L822/F823 from the LLF motif which is conserved in CoV-2-like viruses, and is achieved by the binding of Ca2+ ions to the D830/D839 and E819/D820 residue pairs. FP penetration is shown to modify the molecular organization in specific areas of the bilayer, and the extent of membrane binding of the SARS-CoV-2 FP is significantly reduced in the absence of Ca2+ ions. These findings provide novel mechanistic insights regarding the role of Ca2+ in mediating SARS-CoV-2 fusion and provide a detailed structural platform to aid the ongoing efforts in rational design of compounds to inhibit SARS-CoV-2 cell entry.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.03.410472v2" target="_blank">Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide</a>
 </div></li>
 <li><strong>CoronaHiT: High throughput sequencing of SARS-CoV-2 genomes</strong> -
 <div>
 The COVID-19 pandemic has spread to almost every country in the world since it started in China in late 2019. Controlling the pandemic requires a multifaceted approach including whole genome sequencing to support public health interventions at local and national levels. One of the most widely used methods for sequencing is the ARTIC protocol, a tiling PCR approach followed by Oxford Nanopore sequencing (ONT) of up to 96 samples at a time. There is a need, however, for a flexible, platform agnostic, method that can provide multiple throughput options depending on changing requirements as the pandemic peaks and troughs. Here we present CoronaHiT, a method capable of multiplexing up to 96 small genomes on a single MinION flowcell or &gt;384 genomes on Illumina NextSeq, using transposase mediated addition of adapters and PCR based addition of barcodes to ARTIC PCR products. We demonstrate the method by sequencing 95 and 59 SARS-CoV-2 genomes for routine and rapid outbreak response runs, respectively, on Nanopore and Illumina platforms and compare to the standard ARTIC LoCost nanopore method. Of the 154 samples sequenced using the three approaches, genomes with [≥] 90% coverage (GISAID criteria) were generated for 64.3% of samples for ARTIC LoCost, 71.4% for CoronaHiT-ONT, and 76.6% for CoronaHiT-Illumina and have almost identical clustering on a maximum likelihood tree. In conclusion, we demonstrate that CoronaHiT can multiplex up to 96 SARS-CoV-2 genomes per MinION flowcell and that Illumina sequencing can be performed on the same libraries, which will allow significantly higher throughput. CoronaHiT provides increased coverage for higher Ct samples, thereby increasing the number of high quality genomes that pass the GISAID QC threshold. This protocol will aid the rapid expansion of SARS-CoV-2 genome sequencing globally, to help control the pandemic.
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 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.06.24.162156v2" target="_blank">CoronaHiT: High throughput sequencing of SARS-CoV-2 genomes</a>
 </div></li>
 </ul>
 <h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process<br/><b>Sponsor</b>:   Hospices Civils de Lyon<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Adult</strong> - <b>Condition</b>:   Covid19 Vaccine<br/><b>Interventions</b>:   Biological: MVC-COV1901(S protein with adjuvant);   Biological: MVC-COV1901(Saline)<br/><b>Sponsor</b>:   Medigen Vaccine Biologics Corp.<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Safety and Efficacy of Pyronaridine-artesunate (Pyramax® or Artecom®)in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Artecom® (pyronaridine-artesunate);   Drug: Placebo<br/><b>Sponsor</b>:   Shin Poong Pharmaceutical Co. Ltd.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Two Different Strengths of the Inactivated COVID-19 Vaccine ERUCOV-VAC</strong> - <b>Condition</b>:   COVID-19 Vaccine<br/><b>Interventions</b>:   Biological: ERUCOV-VAC;   Other: Placebo Vaccine<br/><b>Sponsors</b>:   Health Institutes of Turkey;   TC Erciyes University<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Participants ≥ 60 Years of Age and Hospitalized With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: BGE-175;   Other: Placebo<br/><b>Sponsor</b>:   BioAge Labs, Inc.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Deep Breathing Exercise on Dyspnea, Anxiety and Quality of Life in Patients Treated for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Behavioral: Deep Breathing Exercise with Triflo<br/><b>Sponsor</b>:   Ankara University<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RU Anti-SARS-CoV-2 (COVID-19) mAbs in Healthy Volunteers</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: C144-LS and C-135-LS<br/><b>Sponsor</b>:   Rockefeller University<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AZD1222;   Biological: rAd26-S<br/><b>Sponsors</b>:   R-Pharm;   AstraZeneca<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Surgical Face Mask Effects in Patients With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Sit-To-Stand test<br/><b>Sponsor</b>:   Cliniques universitaires Saint-Luc- Université Catholique de Louvain<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: Glycine;   Dietary Supplement: N-acetylcysteine;   Dietary Supplement: Alanine<br/><b>Sponsor</b>:   Baylor College of Medicine<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RespiraConNosotros:a Mobile Application for COVID-19 Respiratory Rehabilitation.</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Breathing exercise<br/><b>Sponsor</b>:   University of Salamanca<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Favipiravir in Treatment of Mild &amp; Moderate COVID-19 Infection in Nepal</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Favipiravir;   Drug: Placebo;   Drug: Remdesivir<br/><b>Sponsor</b>:   Nepal Health Research Council<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dendritic Cell Vaccine, AV-COVID-19, to Prevent COVID-19 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AV-COVID-19;   Other: GM-CSF<br/><b>Sponsors</b>:   Aivita Biomedical, Inc.;   PT AIVITA Biomedika Indonesia;   Indonesia Ministry of Health;   National Institute of Health Research and Development, Ministry of Health Republic of Indonesia<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of the Immunological and Virological Response of Patients With COVID-19 and Presenting an Asymptomatic or Pauci-symptomatic Form (AMBUCOV)</strong> - <b>Conditions</b>:   Covid19;   SARS-CoV-2<br/><b>Interventions</b>:   Diagnostic Test: Blood count;   Diagnostic Test: Blood collection;   Diagnostic Test: Nasopharyngeal swab;   Diagnostic Test: Saliva samples;   Diagnostic Test: Faeces samples;   Genetic: Genetic blood collection;   Other: Data collection<br/><b>Sponsors</b>:   Assistance Publique - Hôpitaux de Paris;   Fonds IMMUNOV<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Real World Study of Bamlanivimab in Participants With Mild-to-moderate Coronavirus Disease 2019 (COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Bamlanivimab<br/><b>Sponsors</b>:   Eli Lilly and Company;   AbCellera Biologics Inc.<br/><b>Not yet recruiting</b></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis</strong> - Elucidating virus-cell interactions is fundamental to understanding viral replication and identifying targets for therapeutic control of viral infection. The extracellular signal-regulated kinase (ERK) pathway has been shown to regulate pathogenesis during many viral infections, but its role during coronavirus infection is undetermined. Infectious bronchitis virus is the representative strain of Gammacoronavirus, which causes acute and highly contagious diseases in the poultry farm. In this...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent the need for effective therapeutics. The experience of combating SARS-CoV and MERS-CoV has shown that inhibiting the 3-chymotrypsin-like protease (3CLpro) blocks the replication of the virus. Given the well-studied properties of FDA-approved drugs,...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Experimental Models to Study COVID-19 Effect in Stem Cells</strong> - The new strain of coronavirus (severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)) emerged in 2019 and hence is often referred to as coronavirus disease 2019 (COVID-19). This disease causes hypoxic respiratory failure and acute respiratory distress syndrome (ARDS), and is considered as the cause of a global pandemic. Very limited reports in addition to ex vivo model systems are available to understand the mechanism of action of this virus, which can be used for testing of any drug...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Drug Repurposing: Dipeptidyl Peptidase IV (DPP4) Inhibitors as Potential Agents to Treat SARS-CoV-2 (2019-nCoV) Infection</strong> - The current outbreak of severe acute respiratory distress syndrome (SARS) or nCOVID-19 pandemic, caused by the coronavirus-2 (CoV-2), continues to wreak havoc globally. As novel vaccines are being discovered and developed, small molecule drugs still constitute a viable treatment option for SARS-CoV-2 infections due to their advantages such as superior patient compliance for oral therapies, reduced manufacturing costs and ease of large scale distribution due to better stability and storage...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease</strong> - Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) in response to a variety of stimuli. These NETs are net-like complexes composed of cell-free DNA, histones and neutrophil granule proteins. Besides the evolutionarily conserved mechanism to capture and eliminate pathogens, NETs are also associated with pathophysiological processes of various diseases. Here, we...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 in teriflunomide-treated patients with multiple sclerosis: A case report and literature review</strong> - CONCLUSION: Available data suggest that teriflunomide therapy should not be discontinued in MS patients who develop SARS-CoV-2 infection, also in presence of significant comorbidities or clinical conditions requiring hospitalization. Additional studies are necessary to assess if the drug can also have a protective role against SARS-CoV-2.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A systematic review of experimental evidence for antiviral effects of ivermectin and an in-silico analysis of ivermectin's possible mode of action against SARS-CoV-2</strong> - Viral infections remain a major cause of economic loss with an unmet need for novel therapeutic agents. Ivermectin is a putative antiviral compound; the proposed mechanism is the inhibition of nuclear translocation of viral proteins, facilitated by mammalian host importins, a necessary process for propagation of infections. We systematically reviewed the evidence for the applicability of ivermectin against viral infections including SARS-CoV-2 regarding efficacy, mechanisms and selective...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACE2-derived peptides interact with the RBD domain of SARS-CoV-2 spike glycoprotein, disrupting the interaction with the human ACE2 receptor</strong> - Vaccines could be the solution to the current SARS-CoV-2 outbreak. However, some studies have shown that the immunological memory only lasts three months. Thus, it is imperative to develop pharmacological treatments to cope with COVID-19. Here, the in silico approach by molecular docking, dynamic simulations and quantum biochemistry revealed that ACE2-derived peptides strongly interact with the SARS-CoV-2 RBD domain of spike glycoprotein (S-RBD). ACE2-Dev-PepI, ACE2-Dev-PepII, ACE2-Dev-PepIII...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity</strong> - Ifenprodil (1) is a potent GluN2B-selective N-methyl-d-aspartate (NMDA) receptor antagonist that is used as a cerebral vasodilator and has been examined in clinical trials for the treatment of drug addiction, idiopathic pulmonary fibrosis, and COVID-19. To correlate biological data with configuration, all four ifenprodil stereoisomers were prepared by diastereoselective reduction and subsequent separation of enantiomers by chiral HPLC. The absolute configuration of ifenprodil stereoisomers was...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy</strong> - COVID-19 is an infectious respiratory illness caused by the virus strain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and until now, there is no effective therapy against COVID-19. Since SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) for entering into host cells, to target COVID-19 from therapeutic angle, we engineered a hexapeptide corresponding to the ACE2-interacting domain of SARS-CoV-2 (AIDS) that inhibits the association between receptor-binding...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potentials of Interferons and Hydroxychloroquine for the Prophylaxis and Early Treatment of COVID-19</strong> - The symptoms of the COVID-19 range from asymptomatic or mild disease to severe disease that results in acute respiratory distress syndrome (ARDS) and eventually death. Understanding the molecular mechanisms responsible for the progression from mild to severe disease is the key to decreasing the mortality of COVID-19. Compared to mild cases, severe cases of the COVID-19 have decreased interferon (IFN) α, β, λ production. Type I (IFN α/β) and III IFNs (λ) work coordinately to induce inhibition of...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CL(pro)</strong> - The COVID-19 has now been declared a global pandemic by the World Health Organization. No approved drug is currently available; therefore, an urgent need has been developed for any antiviral therapy for COVID-19. Main protease 3CL^(pro) of this novel Coronavirus (SARS-CoV-2) play a critical role in the disease propagation, and hence represent a crucial target for the drug discovery. Herein, we have applied a bioinformatics approach for drug repurposing to identify the possible potent inhibitors...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2</strong> - The rapidly developing pandemic, known as coronavirus disease 2019 (COVID-19) and caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently spread across 213 countries and territories. This pandemic is a dire public health threat-particularly for those suffering from hypertension, cardiovascular diseases, pulmonary diseases, or diabetes; without approved treatments, it is likely to persist or recur. To facilitate the rapid discovery of inhibitors with clinical...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M(pro)) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study</strong> - Since the outbreak of the COVID-19 (coronavirus disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants using a molecular docking approach to inhibit the main protease (M^(pro)) and spike (S) glycoprotein of SARS-CoV-2. The evaluation was performed on the...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2</strong> - The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12 million people have been infected so far according to the reports from World Health Organization (WHO). Preventive measures are being taken globally to avoid the rapid spread of virus. In the current study, an in silico approach is carried out as a means of inhibiting the spike protein of the novel coronavirus by flavonoids from natural sources that possess both antiviral and anti-inflammatory...</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid 19 - Chewing Gum</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313269181">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313300659">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19</strong> - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN313339294">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251184">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251182">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>抑制病毒受体ACE2的COVID-19防治药物及其应用</strong> - 本发明提供了一种抑制病毒受体ACE2的COVID‑19防治药物及其应用。具体地说，本发明提供了中药鹅不食草在制备调节ACE2表达量的药物中的应用。本发明还提供了中药鹅不食草单独或与其它药物组合在制备COVID‑19防治药物中的应用。本发明发现鹅不食草能够使正常肺上皮细胞中ACE2的表达降低，从而降低新型冠状病毒(SARS‑CoV‑2)感染的风险，发挥预防SARS‑CoV‑2感染及治疗COVID‑19的作用。中药鹅不食草成本低，毒副作用小，疗效显著，为COVID‑19的治疗提供了新策略。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN313773195">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN312324209">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물</strong> - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR313434044">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU311608060">link</a></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mundschutz für Brillenträger und Brillenadapter</strong> -
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 </p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Mundschutz bestehend aus einem Abdeckteil für den Mund- und gegebenenfalls den Nasenbereich des Gesichts und einem Bandteil mit mindestens einem Halteband, welches mit den Seiten des Abdeckteil verbunden ist und zur Befestigung des Mundschutzes dient, wobei das Halteband am seitlichen Ende des Abdeckteils fixiert ist und eine Schlaufe bildet, dadurch gekennzeichnet, dass an der Schlaufe des Haltebands ein Clip befestigt ist.</p></li>
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 <li><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313866570">link</a></li>
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 <h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-new-yorker">From New Yorker</a></li>
 <li><a href="#from-vox">From Vox</a></li>
 <li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
 <li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
 <li><a href="#from-bbc-europe">From BBC: Europe</a></li>
 <li><a href="#from-ars-technica">From Ars Technica</a></li>
 <li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Case for Removing Donald Trump</strong> - There will be time to assess Trump’s criminal liability for his role in inciting the insurrection. Right now, the urgent issue is the danger of having him remain President. - <a href="https://www.newyorker.com/news/our-columnists/the-case-for-removing-donald-trump">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Black America Has Reason to Question Authorities</strong> - From vaccines to public schools, a history of cruelty and neglect informs Black communities’ relation to the state. - <a href="https://www.newyorker.com/news/our-columnists/black-america-has-reason-to-question-authorities">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump Can’t Be Allowed to Escape Justice Yet Again</strong> - Despite all the outrage sparked by last week’s riot, the President has grounds for believing that he won’t receive any immediate punishment for openly inciting an insurrection. - <a href="https://www.newyorker.com/news/our-columnists/trump-cant-be-allowed-to-escape-justice-yet-again">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Deciding Who Should Be Vaccinated First</strong> - The immunologist Barry Bloom discusses how to balance the vaccination needs of older Americans and frontline workers. - <a href="https://www.newyorker.com/news/q-and-a/deciding-who-should-be-vaccinated-first">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sunday Reading: Waiting for the Vaccine</strong> - From The New Yorker’s archive: stories about the impact of vaccinations and the consequences of anti-vax propaganda. - <a href="https://www.newyorker.com/books/double-take/sunday-reading-waiting-for-the-vaccine">link</a></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-vox">From Vox</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chad Wolf just resigned as acting homeland security secretary</strong> -
 <figure>
 <img alt="" src="https://cdn.vox-cdn.com/thumbor/2rgrC1U54y3jnNC_ZKmnHddLxkA=/146x0:2813x2000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68653031/1228671229.0.jpg"/>
 <figcaption>
 Acting Homeland Security Secretary Chad Wolf looks on prior to his confirmation hearing before the Senate Homeland Security and Governmental Affairs Committee on September 23, 2020, in Washington, DC. | Greg Nash/Getty Images
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 He’s the latest Cabinet official to step down in the wake of last week’s insurrection at the Capitol.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oDOqgo">
 Acting Homeland Security Secretary Chad Wolf announced his resignation Monday, joining a long line of Trump administration officials who have stepped down since the president’s supporters stormed the US Capitol building last week.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BDN33T">
 Wolf — who has served in the position since November 2019 and become the public face of President Donald Trump’s immigration policies — had been <a href="https://www.cnbc.com/2021/01/07/trump-withdraws-chad-wolf-nomination-to-lead-homeland-security.html">planning to remain in his post </a>until President-elect Joe Biden was inaugurated on January 20. He had been overseeing security measures for the inauguration, and <a href="https://twitter.com/courtneyknorris/status/1348735974377926659?s=20">announced Monday </a>that he was extending the “national special security event” period, a designation that facilitates cooperation among federal law enforcement agencies to respond to terrorist or other criminal threats.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P6dMTZ">
 But he reportedly told agency staff later on Monday that ongoing legal challenges to his appointment to the position had precluded him from staying on.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qtTs1q">
 Pete Gaynor, the current Federal Emergency Management Agency administrator, will succeed Wolf.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="841Sa2">
 “Unfortunately, this action is warranted by recent events, including the ongoing and meritless court rulings regarding the validity of my authority as Acting Secretary,” he told agency staff, according to the <a href="https://twitter.com/KannoYoungs/status/1348752728282030085?s=20">New York Times</a>. “These events and concerns increasingly serve to divert attention and resources away from the important work of the Department in this critical time of a transition of power.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AzqsZD">
 Other Trump administration officials who recently stepped down from their posts since last week’s insurrection at the Capitol include Education Secretary Betsy DeVos, Transportation Secretary Elaine Chao, Deputy National Security Adviser Matthew Pottinger, Trump’s special envoy to Northern Ireland Mick Mulvaney, and chief of staff to the first lady Stephanie Grisham.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nQjq3l">
 Though Wolf has frequently gone to bat for the president in the media, reportedly becoming his <a href="https://www.washingtonpost.com/national/chad-wolf-dhs-trump/2020/08/03/38b6adf8-d1d4-11ea-af07-1d058ca137ae_story.html">favorite homeland security secretary</a>, Wolf had publicly urged Trump to strongly condemn last week’s violence.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1OLagh">
 “This is unacceptable. These violent actions are unconscionable, and I implore the President and all elected officials to strongly condemn the violence,” he said in a statement on Thursday. “Any appearance of inciting violence by an elected official goes against who we are as Americans. Every American is guaranteed the right to peacefully protest, but once those protests become violent, we should enforce our laws and bring those responsible to justice — regardless of political motivations.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nGGYq6">
 But his resignation did not appear to be directly tied to last week’s events. Rather, he cited<a href="https://www.vox.com/2020/11/15/21566268/daca-ruling-chad-wolf-dreamers"> several court rulings </a>that he was unlawfully appointed to his position. Judges found that Trump had sidestepped the Senate confirmation process to install him, running afoul of the Federal Vacancies Reform Act. Trump had attempted to rectify the issues with Wolf’s appointment by formally nominating him for the position but <a href="https://www.buzzfeednews.com/article/hamedaleaziz/trump-withdraws-chad-wolf-dhs-nomination">abruptly withdrew</a> the nomination from the Senate last Thursday.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ys1KTM">
 With Wolf continuing to serve in his position without legal authority, his legacy has come into question. One court already <a href="https://www.vox.com/2020/11/15/21566268/daca-ruling-chad-wolf-dreamers">invalidated his memo</a> halting new applications to the Deferred Action for Childhood Arrivals program on the basis of his illegitimate appointment.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QtX8Y2">
 There is no telling whether further legal challenges could invalidate other DHS policies promulgated under Wolf’s watch — or even whether the incoming Biden administration could argue that Wolf’s appointment was unlawful in order to refrain from enforcing agency policies that it opposes.
 </p>
 <h3 id="5HYgp2">
 Wolf became Trump’s mouthpiece on the border
 </h3>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1q4yXk">
 Wolf and his deputy Ken Cuccinelli were at the forefront of Trump’s “law and order” messaging over the summer and have been staunch defenders of the president’s restrictionist immigration policies.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="09CtZV">
 Wolf led the crackdown against Black Lives Matter protests in Portland, Oregon, sending federal agents from Immigration and Customs Enforcement and Customs and Border Protection there on the premise of protecting federal buildings that had been vandalized. The agents later drew criticism for escalating tensions by using tear gas on crowds and detaining protesters in unmarked vehicles.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LOWT4c">
 And in the final weeks before the presidential election, he and Cuccinelli went on a tour of several battleground states — Pennsylvania, <a href="https://www.dhs.gov/news/2020/10/22/remarks-prepared-acting-secretary-chad-f-wolf-highlighting-border-security-and">Arizona</a>, Minnesota, and Texas — holding at least five press conferences to showcase Trump’s immigration policies. Some of the press conferences concerned <a href="https://www.ice.gov/news/releases/ice-announces-arrests-more-100-large-aliens">routine enforcement actions</a> that would typically be publicized with a simple press release.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aW7Tod">
 Wolf made the border wall a prop in the agency’s public messaging. After racing to finish the border wall in the months leading up to the election, he has been eager to claim that Trump made good on his campaign vow. (Some 500 miles of wall have been completed, but Mexico never paid for it — rather, that $15 billion burden fell on taxpayers and largely was transferred from the Pentagon’s budget.)
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SuREEY">
 Wolf traveled to the border on October 29 to tout the progress on construction, making abundantly clear what he thought was at stake in the presidential election. He said that Biden’s policies would create a surge of migration at the border and pose a threat to national security.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yIxjax">
 “Let me be clear, each of those policies would endanger the lives of the border patrol and Americans across the country,” he <a href="https://twitter.com/Haleaziz/status/1321834851629064193?s=20">said</a>.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EagAW3">
 He also tweeted out a video jabbing at journalists who cast doubt on whether Trump would complete the border wall and whether it would even serve its intended purpose of “securing the border.” It’s not clear whether the video was produced by the Department of Homeland Security, but it might as well have been a campaign ad:
 </p>
 <div id="DZw7RE">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 They said it couldn’t be done…<br/><br/>They tried to block it<br/>They tried to spin it<br/>They tried to hide the truth<br/><br/>They were wrong. 400 times and counting. <a href="https://t.co/MWWP4cgoPi">pic.twitter.com/MWWP4cgoPi</a>
 </p>
 — Acting Secretary Chad Wolf (<span class="citation">@DHS_Wolf</span>) <a href="https://twitter.com/DHS_Wolf/status/1321817215910486018?ref_src=twsrc%5Etfw">October 29, 2020</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eHihQY">
 David Lapan, a former spokesperson for DHS, <a href="https://twitter.com/DaveLapanDC/status/1321844966822449153?s=20">called it</a> a “misuse of [government] resources” and “clear electioneering.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zFA5UB">
 The announcement of Wolf’s resignation comes just before Trump’s planned trip to the US-Mexico border on Tuesday, where he is expected to again tout his legacy on immigration.
 </p>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Spain is still digging itself out from its worst snowstorm in 50 years</strong> -
 <figure>
 <img alt="" src="https://cdn.vox-cdn.com/thumbor/WGYSrXJ2O1jYyOi0qNkMkkU_6oE=/281x0:4353x3054/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68652959/GettyImages_1295828849.0.jpg"/>
 <figcaption>
 Vehicles trapped by snow on the M-40 in Madrid, Spain, on January 11, 2021. | Eduardo Parra/Europa Press via Getty Images
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Historic snowfall brought Madrid to a standstill.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GLg4Nu">
 Spain is still digging itself out after the biggest snowstorm to hit the Mediterranean country in <a href="https://www.nytimes.com/2021/01/11/world/europe/spain-snow-storm-filomena.html">50 years</a> slammed the capital, Madrid, and surrounding regions over the weekend, disrupting transit and efforts to distribute coronavirus vaccines, and causing at least four deaths.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3wCwqK">
 The bulk of the snow from Storm Filomena began falling Friday evening and <a href="https://abcnews.go.com/Health/wireStory/spain-shovels-snowdrifts-left-storm-filomena-75160598">left 20 inches</a> in the capital and nearby provinces by the end of Saturday.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bQr64c">
 Rail service in some areas was suspended, and the <a href="https://www.nytimes.com/2021/01/11/world/europe/spain-snow-storm-filomena.html">New York Times</a> reported that 12,500 miles of roads were closed or disrupted. Firefighters, members of the military, and emergency crews worked to clear runways and roads from Friday into Saturday, freeing more than <a href="https://abcnews.go.com/Health/wireStory/spain-shovels-snowdrifts-left-storm-filomena-75160598">1,500 people trapped</a> in their cars in freezing temperatures.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hbPqol">
 Although hundreds of roads had been cleared by Sunday and outgoing flights had resumed at the Madrid-Barajas airport, the Associated Press reported that roads in parts of the country were still largely blocked, and officials warned the country was not yet in the clear.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jtE8Pq">
 “A week of extreme cold is coming and that will transform all the snow on the ground to ice, thereby multiplying the risk,” Interior Minister Fernando Grande-Marlaska <a href="https://apnews.com/article/international-news-madrid-storms-coronavirus-pandemic-weather-155da8d9d3943ae2564fbabf624f9336">told reporters</a> on Sunday. “The storm is bringing with it a cold wave that could push temperatures down to record levels,” he added.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MruhYV">
 At least <a href="https://www.reuters.com/article/idUSKBN29E0B1?edition-redirect=ca">four people died</a> as a result of the storm. Two people experiencing homelessness died from exposure — one near Madrid and another in Calatayud, a city located in the country’s northeast. A woman and a man also drowned after their car was swept away in floods when a river burst close to the southern town of Malaga.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uraHhz">
 Government authorities on Sunday cautioned people to stay off the roads as much as possible, the <a href="https://apnews.com/article/international-news-madrid-storms-coronavirus-pandemic-weather-155da8d9d3943ae2564fbabf624f9336">AP reported</a>, saying that although everyone trapped in their vehicles had been rescued, many abandoned vehicles remained on roadways.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yaPWjU">
 Many Spaniards took advantage of the snow to enjoy some winter fun. On social media, scenes of Spaniards in the streets, happily engaging in mass snowball fights made the rounds.
 </p>
 <div id="d3VvqK">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 Madrid's Gran Via today was the scene of an epic snowball battle interumpted briefly by a skier who swiftly became the target <a href="https://twitter.com/hashtag/NieveInMadrid?src=hash&amp;ref_src=twsrc%5Etfw">#NieveInMadrid</a> <a href="https://twitter.com/hashtag/Filomena?src=hash&amp;ref_src=twsrc%5Etfw">#Filomena</a> <a href="https://twitter.com/hashtag/NevadaMadrid?src=hash&amp;ref_src=twsrc%5Etfw">#NevadaMadrid</a> <a href="https://twitter.com/hashtag/Madrid?src=hash&amp;ref_src=twsrc%5Etfw">#Madrid</a> <a href="https://twitter.com/hashtag/nievemadrid?src=hash&amp;ref_src=twsrc%5Etfw">#nievemadrid</a> <a href="https://twitter.com/hashtag/snow?src=hash&amp;ref_src=twsrc%5Etfw">#snow</a> <a href="https://t.co/cGsD4Y1ig1">pic.twitter.com/cGsD4Y1ig1</a>
 </p>
 — The Local Spain (<span class="citation">@TheLocalSpain</span>) <a href="https://twitter.com/TheLocalSpain/status/1347968078127226880?ref_src=twsrc%5Etfw">January 9, 2021</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tLKL7N">
 Some revelers were even seen skiing through Madrid’s streets.
 </p>
 <div id="OfvGlB">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 Skiing the streets of MADRID! <a href="https://twitter.com/hashtag/spain?src=hash&amp;ref_src=twsrc%5Etfw">#spain</a> <a href="https://twitter.com/hashtag/Espana?src=hash&amp;ref_src=twsrc%5Etfw">#Espana</a> <a href="https://twitter.com/hashtag/snow?src=hash&amp;ref_src=twsrc%5Etfw">#snow</a> <a href="https://twitter.com/hashtag/madridsnow?src=hash&amp;ref_src=twsrc%5Etfw">#madridsnow</a> <a href="https://t.co/kNdED5x7Yb">pic.twitter.com/kNdED5x7Yb</a>
 </p>
 — Evan Kirstel #CES2021 (<span class="citation">@EvanKirstel</span>) <a href="https://twitter.com/EvanKirstel/status/1348065846288125964?ref_src=twsrc%5Etfw">January 10, 2021</a>
 </blockquote>
 </div>
 <h3 id="zDuErJ">
 What’s behind Spain’s historic snow?
 </h3>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6m1QLS">
 Although Spanish reports predicted snow, few expected it would be so intense.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="trojdd">
 Rubén del Campo, a spokesperson for Spain’s government meteorological office, Aemet, <a href="https://www.theguardian.com/world/2021/jan/09/army-rescues-motorists-after-storm-filomena-blankets-spain-in-snow#:~:text=Storm%20Filomena%20hit%20Spain%20on,parts%20of%20the%20Madrid%20region.">told reporters</a> that “you’d probably have to look back to the 1970s for snowfall of a similar magnitude in and around the capital.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SwpbVj">
 It can be incredibly difficult to pinpoint exactly what combination of factors produced this (or any) extreme weather event, but experts I spoke to said Filomena’s historic snowfall might have happened because high levels of moisture combined with temperatures that are perfect for snow, at just the right time.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9FcZMx">
 In general, the warmer the air, the more moisture it can hold, increasing the potential for precipitation. It’s possible the air before Filomena contained more moisture and then met the “<a href="https://theconversation.com/does-global-warming-mean-more-or-less-snow-36936">Goldilocks conditions</a>” of about 28°F to 32°F that’s necessary for snowfall to stick on the Earth’s surface.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iB6R4S">
 As Kevin Trenberth of the US National Center for Atmospheric Research<strong> </strong>told me, “Maximum snows occur when surface temperatures are about 28 degrees Fahrenheit and there is plenty of moisture flowing into the storm from the oceans, where moisture is abundant, and more abundant than it used to be because of global warming.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lrovbe">
 In the case of Filomena, Trenberth added, “conditions were just right.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2G0IA6">
 That doesn’t necessarily mean climate change is directly responsible for Spain’s snowstorm, though.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OpiL0v">
 “It isn’t possible to associate this one storm with anything directly associated with climate change,” Robinson, from Rutgers, told me. “However, having said this, there is nothing in the weather world these days where climate change doesn’t have some underlying influence on what transpires.”
 </p>
 <h3 id="joqPIx">
 </h3>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>About half of Republicans don’t think Joe Biden should be sworn in as president</strong> -
 <figure>
 <img alt="" src="https://cdn.vox-cdn.com/thumbor/94xrTCsSjxB1OHPWxVJLwBeM_EM=/182x0:3922x2805/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68652896/GettyImages_1267250919.0.jpg"/>
 <figcaption>
 Then-presidential nominee Joe Biden at the Democratic National Convention in August in Wilmington, Delaware. | Win McNamee/Getty Images
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 A new Vox/DFP poll finds that most Republicans are still questioning the election results.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mmOqPK">
 <a href="https://www.vox.com/22218006/congress-electoral-vote-count-joe-biden-president">Despite the congressional certification of the presidential election results last week</a>, an overwhelming majority of Republicans still don’t trust the outcome — and almost half don’t think that President-elect Joe Biden should be inaugurated, <a href="https://filesforprogress.org/datasets/2021/1/dfp_vox_election_trust.pdf">according to a new poll from Vox and Data for Progress</a>.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u55wAk">
 In a survey fielded in the days after a group of President Donald Trump’s supporters stormed the US Capitol (January 8 to 11), 72 percent of likely Republican voters said they continue to question the presidential election results. Nearly three-quarters of Republicans, or 74 percent, said allegations of voter fraud have contributed to these concerns. Those are overwhelming majorities, but even among independents, 42 percent said they do not currently trust the election results.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iqAcXV">
 The GOP is more split on the presidential transition, with 49 percent of Republicans saying they have doubts about the election outcome and oppose Biden’s inauguration, 29 percent saying they still have doubts about the outcome but believe Biden should be inaugurated, and 16 percent saying they trust the election results and think Biden should be inaugurated. A total of 1,233 likely voters were polled for the survey, which has a margin of error of 2.8 percentage points.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e3wib2">
 More broadly, <a href="https://www.vox.com/22214061/trump-congress-2020-election-steal-democracy-authoritarian-coup">Trump’s repeated unfounded allegations of election fraud</a> appear to be affecting how people perceive the electoral system overall — not just the 2020 presidential contest. While 55 percent of people said they continue to trust the electoral process in the United States, 39 percent of people said they don’t trust it, including 65 percent of Republicans, compared to 12 percent of Democrats.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V2rL4c">
 These findings are consistent with those in other recent surveys: <a href="https://poll.qu.edu/images/polling/us/us01112021_usmk38.pdf">A Quinnipiac poll out Monday</a> also found that 73 percent of Republicans believe there’s widespread voter fraud, compared to 5 percent of Democrats who felt the same.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NuqwwN">
 These results indicate that the allegations raised by Trump and his Republican allies have resonated with a large majority of the Republican base, so much so that some remain opposed to the presidential transition because of the doubts they harbor about the election results. This sharp divide in perceptions about the election outcome is also evident in how people interpreted the storming of the Capitol last week, this Vox/DFP poll finds. Such splits could have major implications for how Republican lawmakers approach policies under the incoming Biden administration, particularly if much of their base is wary of the legitimacy of his presidency.
 </p>
 <h3 id="h2GeDo">
 Reactions to the storming of the Capitol fell heavily along party lines
 </h3>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jUpDBt">
 People’s perceptions of the attack on the Capitol last week also differed significantly based on their party affiliation. Eighty-one percent of Democrats viewed the riot — which took place as Congress was certifying the presidential election results — as a threat to democracy, while 64 percent of independents and 47 percent of Republicans felt the same.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CyPeAU">
 Democrats were also far more likely to say that President Donald Trump and congressional lawmakers were to blame for inciting the violence that took place at the Capitol, while Republicans were more likely to blame Democrats in Congress, President-elect Biden, and anti-fascist protesters, or antifa. <a href="https://www.vox.com/22217747/republicans-antifa-storm-the-capitol-trump-washington-dc-stop-steal-impeachment-election-hawley-cruz">As Vox’s Jerusalem Demsas reported</a>, some conservative lawmakers began falsely blaming the violence on antifa shortly after the attacks took place last week, an explanation that appears to have caught on with some members of the party.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kZkZ9Z">
 Overall, 63 percent of people blame Trump for inciting the violence, including 90 percent of Democrats and 32 percent of Republicans, and 51 percent of people blame Republican lawmakers, including 78 percent of Democrats and 25 percent of Republicans. Meanwhile, 37 percent of people blame Democratic lawmakers, including 11 percent of Democrats and 61 percent of Republicans, and 30 percent blame Biden, including 9 percent of Democrats and 53 percent of Republicans. Forty-seven percent of people blame antifa, including 29 percent of Democrats and 68 percent of Republicans.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wJOARV">
 Opinions regarding how lawmakers should respond to the attack also fall largely along party lines. Fifty-two percent of all people think the 25th Amendment should be invoked and Vice President Mike Pence should force Trump to step down, while 51 percent of people think Trump should be impeached. Eighty-five percent of Democrats back impeachment, while 17 percent of Republicans do. The House is poised to vote on Trump’s impeachment for the second time this week, <a href="https://www.vox.com/22220587/why-democrats-are-moving-toward-impeachment-trump">this time charging him with inciting an insurrection</a>.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VKd7QD">
 As this poll makes clear, many Republicans still believe allegations of voter fraud that Trump has misleadingly raised for months, and some are even doubting the Democratic process because of them.
 </p>
 <h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ankita moves to final round, Ramkumar bows out of Australian Open Qualifiers</strong> - Only Nirupama Vaidyanathan and Sania Mirza have competed in the women’s singles main draw of a Grand Slam from India till date.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aus vs Ind fourth Test | BCCI intervenes after Team India denied basic facilities in Brisbane hotel</strong> - BCCI president Sourav Ganguly, secretary Jay Shah and CEO Hemang Amin have all got in touch with their Cricket Australia counterparts.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Thailand Open: Sindhu, Praneeth lose on return to competition</strong> - No coaches, managers or other personnel are allowed to attend matches of Indian players after Saina and HS Prannoy tested positive for COVID-19.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Syed Mushtaq Ali Trophy | Kerala has it easy against Puducherry</strong> - Jalaj stifles the middle-order to claim three wickets; Sreesanth impresses on comeback</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tokyo Olympic president tries to reassure doubting country</strong> - In what was billed as a New Year's address, Mori gave a little pep talk aimed at the July 23 opening of the Olympics.</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watch | All about the bird flu outbreak in India</strong> - A video explainer on the Avian Influenza outbreak in India</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DC vs MLAs again or much ado about nothing ?</strong> - Rohini Sindhuri leaves meeting of Assembly panel</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>54.72 lakh COVID-19 vaccine doses received till Tuesday afternoon, says Centre</strong> - A massive pan-India inoculation drive against COVID-19 was set in process with Covishield vaccine leaving Pune for 13 cities.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Manipur completes urban local bodies reforms; gets nod for ₹75 crore additional borrowing</strong> - Andhra Pradesh, Madhya Pradesh and Telangana are the other States which have undertaken urban local bodies reforms stipulated by the Department of Expenditure, Ministry of Finance.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBI can probe LIFE Mission CEO: HC</strong> - Court dismisses petitions filed by U.V. Jose, Santhosh Eappen</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Irish report to expose mother-and-baby homes cruelty</strong> - Taoiseach Micheál Martin said the findings of the report are a "shocking and difficult read".</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Diary Sow: Talented Senegal student disappears in France</strong> - An investigation is opened into the disappearance of Diary Sow who has not been seen since 4 January.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit leaves Spain's Costa Brits facing dilemmas</strong> - British expats in Spain tell the BBC how the new post-Brexit rules have changed their lives.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: UK driver has ham sandwiches confiscated at Dutch border</strong> - Dutch TV films officials confiscating ham sandwiches from UK drivers under new food import rules.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beny Steinmetz: Mining tycoon in Swiss trial over Guinea deal</strong> - Billionaire Beny Steinmetz denies alleged corruption over a huge iron ore deal in Guinea.</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jared Mauch didn’t have good broadband—so he built his own fiber ISP</strong> - "I had to start a telephone company to get [high-speed] Internet access." - <a href="https://arstechnica.com/?p=1731541">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sean Bean joins cast as the elusive Mr. Wilford in Snowpiercer S2 trailer</strong> - "The apocalypse isn't so bad, really." - <a href="https://arstechnica.com/?p=1734341">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Codebreaker honors Quaker woman who helped bring down Nazi spy ring</strong> - Elizebeth Smith Friedman and her husband William Friedman helped pioneer cryptology. - <a href="https://arstechnica.com/?p=1734072">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Facebook says it’s blocking posts with the phrase “stop the steal”</strong> - Salesforce says it won't let Trump send out incendiary fundraising emails. - <a href="https://arstechnica.com/?p=1734287">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Parler goes dark, sues Amazon to demand immediate reinstatement</strong> - Bereft of other options, Parler is trying to petition the courts for resurrection. - <a href="https://arstechnica.com/?p=1734089">link</a></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
 <ul>
 <li><strong>The son of a bitch</strong> - <!-- SC_OFF -->
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 Henry was doing maths homework, saying to himself...
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 "2+5, the son of a bitch is 7"
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 "3+6, the son of a bitch is 9"
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 His mother heard this &amp; asked, " Henry ! What is this nonsense you are doing?"
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 "Oh Mom. Don't disturb. I am doing my maths homework"
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 Mom: "Is this how your teacher taught you?"
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 "Yes mom "
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Infuriated mother picked up her cell phone and called the teacher:
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 "Are you teaching maths to children by saying... 2+2, the son of a bitch is 4?"
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 There was silence for a moment
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 Then the teacher started laughing :
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 "What I taught them was... 2+2 THE SUM OF WHICH IS 4."
 </p>
 <hr/>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/humanaura"> /u/humanaura </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kvjjdl/the_son_of_a_bitch/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kvjjdl/the_son_of_a_bitch/">[comments]</a></span></p></li>
 <li><strong>When I woke up this morning, my girlfriend was cooking breakfast in nothing than a T-shirt...</strong> - <!-- SC_OFF -->
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 ...when I came downstairs, she told me she needed me to have sex with her right away...
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 Needless to say I was thrilled, so we did it right there in the kitchen...
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 ...she immediately went back to cooking... we didn't usually do stuff like that, so I hesitantly asked, "so...what was that all about?"
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 She said, "I had 5 minutes left on the casserole, but the timer broke."
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/Flip_Six_Three_Hole"> /u/Flip_Six_Three_Hole </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kv8pmm/when_i_woke_up_this_morning_my_girlfriend_was/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kv8pmm/when_i_woke_up_this_morning_my_girlfriend_was/">[comments]</a></span></p></li>
 <li><strong>A guy is browsing in a pet shop and sees a parrot sitting on a little perch. It doesn't have any feet or legs. The guy says aloud, "Jeeez, I wonder what happened to this parrot?" The parrot says, "I was born this way. I'm a defective parrot."</strong> - <!-- SC_OFF -->
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 "Holy crap," the guy replies. "You actually understood and answered me!" "I got every word," says the parrot. "Ask me anything, I'll answer whatever you want."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 "Okay," the guy says. "How can you hang onto your perch without any feet?" "Well," the parrot says, "this is very embarrassing but since you asked, I wrap my weenie around this wooden bar like a little hook. You can't see it because of my feathers." "Wow," says the guy. "You really can understand and speak English, can't you?" "Actually, I speak both Spanish and English, and I can converse with reasonable competence on almost any topic: politics, religion, sports, physics, philosophy. I'm especially good at ornithology. You really ought to buy me. I'd be a great companion."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The guy looks at the $200.00 price tag. "Sorry, but I just can't afford that." "Pssssssst," says the parrot, "I'm defective, so the truth is, nobody wants me cause I don't have any feet. You can probably get me for $20; just make the guy an offer!" The guy offers $20 and walks out with the parrot. Weeks go by. The parrot is sensational. He has a great sense of humor, he's interesting, he's a great pal, he understands everything, he sympathizes, and he's insightful. The guy is delighted. One day the guy comes home from work and the parrot goes, "Pssssssst," and motions him over with one wing.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 "I don't know if I should tell you this or not, but it's about your wife and the postman." "What are you talking about?" asks the guy. "When the postman delivered the mail today, your wife greeted him at the door in a sheer black nightie." "WHAT???" the guy asks incredulously. "THEN what happened?" "Well, then the postman came into the house and lifted up her nightie and began petting her all over," reported the parrot. "NO!" he exclaims. "And she let him?" "Yes. Then he continued taking off the nightie, got down on his knees and began to kiss her all over..." Then the frantic guy demands, "THEN WHAT HAPPENED?"
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 "Damned if I know... I got a hard-on and fell off my perch!"
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/throughmethroughyou"> /u/throughmethroughyou </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kved0r/a_guy_is_browsing_in_a_pet_shop_and_sees_a_parrot/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kved0r/a_guy_is_browsing_in_a_pet_shop_and_sees_a_parrot/">[comments]</a></span></p></li>
 <li><strong>A math professor, Dave, has a problem with his sink so he calls a plumber.</strong> - <!-- SC_OFF -->
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The plumber comes over and quickly fixes the sink. The professor is happy until he gets the bill. He tells the plumber, "How can you charge this much? This is half of my paycheck." But he pays it anyways.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The plumber tells him, "Hey, we are looking for more plumbers. You could become a plumber and triple your salary. Just make sure you say you only made it to 6th grade, they don't like educated people."
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The professor takes him up on the offer and becomes a plumber. His salary triples and he doesn't have to work nearly as hard. But the company makes an announcement that all of their plumbers must get a 7th grade education. So they all go to night school.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 On the first day of night school they all attend math class. The teacher wants to gauge the class so he asks Dave, "What is the formula for the area of a circle?"
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Dave walks up to the board and is about to write the formula when he realizes he has forgotten it. So he begins to attempt to derive the formula, filling the board with complicated mathematics. He ends up figuring out it is negative pi times radius squared. He thinks the minus doesn't belong so he starts over, but again he comes up with the same equation. After staring at the board for a minute he looks out at the other plumbers and sees that they are all whispering,
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 "Switch the limits on the integral!"
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/MudakMudakov"> /u/MudakMudakov </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kvjhsk/a_math_professor_dave_has_a_problem_with_his_sink/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kvjhsk/a_math_professor_dave_has_a_problem_with_his_sink/">[comments]</a></span></p></li>
 <li><strong>If I’m reading their lips correctly,</strong> - <!-- SC_OFF -->
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 my neighbors are arguing about some creepy guy next door.
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/bot_10"> /u/bot_10 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kvls2x/if_im_reading_their_lips_correctly/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kvls2x/if_im_reading_their_lips_correctly/">[comments]</a></span></p></li>
 </ul>
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