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+ + + +Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air - Condition: Covid19
Intervention: Diagnostic Test: Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process
Sponsor: Hospices Civils de Lyon
Not yet recruiting
A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Adult - Condition: Covid19 Vaccine
Interventions: Biological: MVC-COV1901(S protein with adjuvant); Biological: MVC-COV1901(Saline)
Sponsor: Medigen Vaccine Biologics Corp.
Recruiting
The Safety and Efficacy of Pyronaridine-artesunate (Pyramax® or Artecom®)in COVID-19 Patients - Condition: Covid19
Interventions: Drug: Artecom® (pyronaridine-artesunate); Drug: Placebo
Sponsor: Shin Poong Pharmaceutical Co. Ltd.
Not yet recruiting
Safety and Immunogenicity of Two Different Strengths of the Inactivated COVID-19 Vaccine ERUCOV-VAC - Condition: COVID-19 Vaccine
Interventions: Biological: ERUCOV-VAC; Other: Placebo Vaccine
Sponsors: Health Institutes of Turkey; TC Erciyes University
Recruiting
Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Participants ≥ 60 Years of Age and Hospitalized With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure - Condition: Covid19
Interventions: Drug: BGE-175; Other: Placebo
Sponsor: BioAge Labs, Inc.
Not yet recruiting
The Effect of Deep Breathing Exercise on Dyspnea, Anxiety and Quality of Life in Patients Treated for COVID-19 - Condition: COVID-19
Intervention: Behavioral: Deep Breathing Exercise with Triflo
Sponsor: Ankara University
Not yet recruiting
RU Anti-SARS-CoV-2 (COVID-19) mAbs in Healthy Volunteers - Condition: Covid19
Intervention: Biological: C144-LS and C-135-LS
Sponsor: Rockefeller University
Recruiting
Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19. - Condition: COVID-19
Interventions: Biological: AZD1222; Biological: rAd26-S
Sponsors: R-Pharm; AstraZeneca
Not yet recruiting
Surgical Face Mask Effects in Patients With COVID-19 - Condition: Covid19
Intervention: Other: Sit-To-Stand test
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Not yet recruiting
Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19 - Condition: Covid19
Interventions: Dietary Supplement: Glycine; Dietary Supplement: N-acetylcysteine; Dietary Supplement: Alanine
Sponsor: Baylor College of Medicine
Recruiting
RespiraConNosotros:a Mobile Application for COVID-19 Respiratory Rehabilitation. - Condition: Covid19
Intervention: Other: Breathing exercise
Sponsor: University of Salamanca
Not yet recruiting
Efficacy of Favipiravir in Treatment of Mild & Moderate COVID-19 Infection in Nepal - Condition: Covid19
Interventions: Drug: Favipiravir; Drug: Placebo; Drug: Remdesivir
Sponsor: Nepal Health Research Council
Recruiting
Dendritic Cell Vaccine, AV-COVID-19, to Prevent COVID-19 Infection - Condition: COVID-19
Interventions: Biological: AV-COVID-19; Other: GM-CSF
Sponsors: Aivita Biomedical, Inc.; PT AIVITA Biomedika Indonesia; Indonesia Ministry of Health; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
Recruiting
Study of the Immunological and Virological Response of Patients With COVID-19 and Presenting an Asymptomatic or Pauci-symptomatic Form (AMBUCOV) - Conditions: Covid19; SARS-CoV-2
Interventions: Diagnostic Test: Blood count; Diagnostic Test: Blood collection; Diagnostic Test: Nasopharyngeal swab; Diagnostic Test: Saliva samples; Diagnostic Test: Faeces samples; Genetic: Genetic blood collection; Other: Data collection
Sponsors: Assistance Publique - Hôpitaux de Paris; Fonds IMMUNOV
Not yet recruiting
A Real World Study of Bamlanivimab in Participants With Mild-to-moderate Coronavirus Disease 2019 (COVID-19) - Condition: COVID-19
Intervention: Drug: Bamlanivimab
Sponsors: Eli Lilly and Company; AbCellera Biologics Inc.
Not yet recruiting
Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis - Elucidating virus-cell interactions is fundamental to understanding viral replication and identifying targets for therapeutic control of viral infection. The extracellular signal-regulated kinase (ERK) pathway has been shown to regulate pathogenesis during many viral infections, but its role during coronavirus infection is undetermined. Infectious bronchitis virus is the representative strain of Gammacoronavirus, which causes acute and highly contagious diseases in the poultry farm. In this...
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent the need for effective therapeutics. The experience of combating SARS-CoV and MERS-CoV has shown that inhibiting the 3-chymotrypsin-like protease (3CLpro) blocks the replication of the virus. Given the well-studied properties of FDA-approved drugs,...
Experimental Models to Study COVID-19 Effect in Stem Cells - The new strain of coronavirus (severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)) emerged in 2019 and hence is often referred to as coronavirus disease 2019 (COVID-19). This disease causes hypoxic respiratory failure and acute respiratory distress syndrome (ARDS), and is considered as the cause of a global pandemic. Very limited reports in addition to ex vivo model systems are available to understand the mechanism of action of this virus, which can be used for testing of any drug...
Drug Repurposing: Dipeptidyl Peptidase IV (DPP4) Inhibitors as Potential Agents to Treat SARS-CoV-2 (2019-nCoV) Infection - The current outbreak of severe acute respiratory distress syndrome (SARS) or nCOVID-19 pandemic, caused by the coronavirus-2 (CoV-2), continues to wreak havoc globally. As novel vaccines are being discovered and developed, small molecule drugs still constitute a viable treatment option for SARS-CoV-2 infections due to their advantages such as superior patient compliance for oral therapies, reduced manufacturing costs and ease of large scale distribution due to better stability and storage...
Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease - Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) in response to a variety of stimuli. These NETs are net-like complexes composed of cell-free DNA, histones and neutrophil granule proteins. Besides the evolutionarily conserved mechanism to capture and eliminate pathogens, NETs are also associated with pathophysiological processes of various diseases. Here, we...
COVID-19 in teriflunomide-treated patients with multiple sclerosis: A case report and literature review - CONCLUSION: Available data suggest that teriflunomide therapy should not be discontinued in MS patients who develop SARS-CoV-2 infection, also in presence of significant comorbidities or clinical conditions requiring hospitalization. Additional studies are necessary to assess if the drug can also have a protective role against SARS-CoV-2.
A systematic review of experimental evidence for antiviral effects of ivermectin and an in-silico analysis of ivermectin's possible mode of action against SARS-CoV-2 - Viral infections remain a major cause of economic loss with an unmet need for novel therapeutic agents. Ivermectin is a putative antiviral compound; the proposed mechanism is the inhibition of nuclear translocation of viral proteins, facilitated by mammalian host importins, a necessary process for propagation of infections. We systematically reviewed the evidence for the applicability of ivermectin against viral infections including SARS-CoV-2 regarding efficacy, mechanisms and selective...
ACE2-derived peptides interact with the RBD domain of SARS-CoV-2 spike glycoprotein, disrupting the interaction with the human ACE2 receptor - Vaccines could be the solution to the current SARS-CoV-2 outbreak. However, some studies have shown that the immunological memory only lasts three months. Thus, it is imperative to develop pharmacological treatments to cope with COVID-19. Here, the in silico approach by molecular docking, dynamic simulations and quantum biochemistry revealed that ACE2-derived peptides strongly interact with the SARS-CoV-2 RBD domain of spike glycoprotein (S-RBD). ACE2-Dev-PepI, ACE2-Dev-PepII, ACE2-Dev-PepIII...
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity - Ifenprodil (1) is a potent GluN2B-selective N-methyl-d-aspartate (NMDA) receptor antagonist that is used as a cerebral vasodilator and has been examined in clinical trials for the treatment of drug addiction, idiopathic pulmonary fibrosis, and COVID-19. To correlate biological data with configuration, all four ifenprodil stereoisomers were prepared by diastereoselective reduction and subsequent separation of enantiomers by chiral HPLC. The absolute configuration of ifenprodil stereoisomers was...
ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy - COVID-19 is an infectious respiratory illness caused by the virus strain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and until now, there is no effective therapy against COVID-19. Since SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) for entering into host cells, to target COVID-19 from therapeutic angle, we engineered a hexapeptide corresponding to the ACE2-interacting domain of SARS-CoV-2 (AIDS) that inhibits the association between receptor-binding...
Potentials of Interferons and Hydroxychloroquine for the Prophylaxis and Early Treatment of COVID-19 - The symptoms of the COVID-19 range from asymptomatic or mild disease to severe disease that results in acute respiratory distress syndrome (ARDS) and eventually death. Understanding the molecular mechanisms responsible for the progression from mild to severe disease is the key to decreasing the mortality of COVID-19. Compared to mild cases, severe cases of the COVID-19 have decreased interferon (IFN) α, β, λ production. Type I (IFN α/β) and III IFNs (λ) work coordinately to induce inhibition of...
Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CL(pro) - The COVID-19 has now been declared a global pandemic by the World Health Organization. No approved drug is currently available; therefore, an urgent need has been developed for any antiviral therapy for COVID-19. Main protease 3CL^(pro) of this novel Coronavirus (SARS-CoV-2) play a critical role in the disease propagation, and hence represent a crucial target for the drug discovery. Herein, we have applied a bioinformatics approach for drug repurposing to identify the possible potent inhibitors...
Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2 - The rapidly developing pandemic, known as coronavirus disease 2019 (COVID-19) and caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently spread across 213 countries and territories. This pandemic is a dire public health threat-particularly for those suffering from hypertension, cardiovascular diseases, pulmonary diseases, or diabetes; without approved treatments, it is likely to persist or recur. To facilitate the rapid discovery of inhibitors with clinical...
Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M(pro)) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study - Since the outbreak of the COVID-19 (coronavirus disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants using a molecular docking approach to inhibit the main protease (M^(pro)) and spike (S) glycoprotein of SARS-CoV-2. The evaluation was performed on the...
In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2 - The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12 million people have been infected so far according to the reports from World Health Organization (WHO). Preventive measures are being taken globally to avoid the rapid spread of virus. In the current study, an in silico approach is carried out as a means of inhibiting the spike protein of the novel coronavirus by flavonoids from natural sources that possess both antiviral and anti-inflammatory...
Covid 19 - Chewing Gum - - link
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
抑制病毒受体ACE2的COVID-19防治药物及其应用 - 本发明提供了一种抑制病毒受体ACE2的COVID‑19防治药物及其应用。具体地说,本发明提供了中药鹅不食草在制备调节ACE2表达量的药物中的应用。本发明还提供了中药鹅不食草单独或与其它药物组合在制备COVID‑19防治药物中的应用。本发明发现鹅不食草能够使正常肺上皮细胞中ACE2的表达降低,从而降低新型冠状病毒(SARS‑CoV‑2)感染的风险,发挥预防SARS‑CoV‑2感染及治疗COVID‑19的作用。中药鹅不食草成本低,毒副作用小,疗效显著,为COVID‑19的治疗提供了新策略。 - link
"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link
제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - link
Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link
+
Mundschutz bestehend aus einem Abdeckteil für den Mund- und gegebenenfalls den Nasenbereich des Gesichts und einem Bandteil mit mindestens einem Halteband, welches mit den Seiten des Abdeckteil verbunden ist und zur Befestigung des Mundschutzes dient, wobei das Halteband am seitlichen Ende des Abdeckteils fixiert ist und eine Schlaufe bildet, dadurch gekennzeichnet, dass an der Schlaufe des Haltebands ein Clip befestigt ist.
The Case for Removing Donald Trump - There will be time to assess Trump’s criminal liability for his role in inciting the insurrection. Right now, the urgent issue is the danger of having him remain President. - link
Black America Has Reason to Question Authorities - From vaccines to public schools, a history of cruelty and neglect informs Black communities’ relation to the state. - link
Trump Can’t Be Allowed to Escape Justice Yet Again - Despite all the outrage sparked by last week’s riot, the President has grounds for believing that he won’t receive any immediate punishment for openly inciting an insurrection. - link
Deciding Who Should Be Vaccinated First - The immunologist Barry Bloom discusses how to balance the vaccination needs of older Americans and frontline workers. - link
Sunday Reading: Waiting for the Vaccine - From The New Yorker’s archive: stories about the impact of vaccinations and the consequences of anti-vax propaganda. - link
+He’s the latest Cabinet official to step down in the wake of last week’s insurrection at the Capitol. +
++Acting Homeland Security Secretary Chad Wolf announced his resignation Monday, joining a long line of Trump administration officials who have stepped down since the president’s supporters stormed the US Capitol building last week. +
++Wolf — who has served in the position since November 2019 and become the public face of President Donald Trump’s immigration policies — had been planning to remain in his post until President-elect Joe Biden was inaugurated on January 20. He had been overseeing security measures for the inauguration, and announced Monday that he was extending the “national special security event” period, a designation that facilitates cooperation among federal law enforcement agencies to respond to terrorist or other criminal threats. +
++But he reportedly told agency staff later on Monday that ongoing legal challenges to his appointment to the position had precluded him from staying on. +
++Pete Gaynor, the current Federal Emergency Management Agency administrator, will succeed Wolf. +
++“Unfortunately, this action is warranted by recent events, including the ongoing and meritless court rulings regarding the validity of my authority as Acting Secretary,” he told agency staff, according to the New York Times. “These events and concerns increasingly serve to divert attention and resources away from the important work of the Department in this critical time of a transition of power.” +
++Other Trump administration officials who recently stepped down from their posts since last week’s insurrection at the Capitol include Education Secretary Betsy DeVos, Transportation Secretary Elaine Chao, Deputy National Security Adviser Matthew Pottinger, Trump’s special envoy to Northern Ireland Mick Mulvaney, and chief of staff to the first lady Stephanie Grisham. +
++Though Wolf has frequently gone to bat for the president in the media, reportedly becoming his favorite homeland security secretary, Wolf had publicly urged Trump to strongly condemn last week’s violence. +
++“This is unacceptable. These violent actions are unconscionable, and I implore the President and all elected officials to strongly condemn the violence,” he said in a statement on Thursday. “Any appearance of inciting violence by an elected official goes against who we are as Americans. Every American is guaranteed the right to peacefully protest, but once those protests become violent, we should enforce our laws and bring those responsible to justice — regardless of political motivations.” +
++But his resignation did not appear to be directly tied to last week’s events. Rather, he cited several court rulings that he was unlawfully appointed to his position. Judges found that Trump had sidestepped the Senate confirmation process to install him, running afoul of the Federal Vacancies Reform Act. Trump had attempted to rectify the issues with Wolf’s appointment by formally nominating him for the position but abruptly withdrew the nomination from the Senate last Thursday. +
++With Wolf continuing to serve in his position without legal authority, his legacy has come into question. One court already invalidated his memo halting new applications to the Deferred Action for Childhood Arrivals program on the basis of his illegitimate appointment. +
++There is no telling whether further legal challenges could invalidate other DHS policies promulgated under Wolf’s watch — or even whether the incoming Biden administration could argue that Wolf’s appointment was unlawful in order to refrain from enforcing agency policies that it opposes. +
++Wolf and his deputy Ken Cuccinelli were at the forefront of Trump’s “law and order” messaging over the summer and have been staunch defenders of the president’s restrictionist immigration policies. +
++Wolf led the crackdown against Black Lives Matter protests in Portland, Oregon, sending federal agents from Immigration and Customs Enforcement and Customs and Border Protection there on the premise of protecting federal buildings that had been vandalized. The agents later drew criticism for escalating tensions by using tear gas on crowds and detaining protesters in unmarked vehicles. +
++And in the final weeks before the presidential election, he and Cuccinelli went on a tour of several battleground states — Pennsylvania, Arizona, Minnesota, and Texas — holding at least five press conferences to showcase Trump’s immigration policies. Some of the press conferences concerned routine enforcement actions that would typically be publicized with a simple press release. +
++Wolf made the border wall a prop in the agency’s public messaging. After racing to finish the border wall in the months leading up to the election, he has been eager to claim that Trump made good on his campaign vow. (Some 500 miles of wall have been completed, but Mexico never paid for it — rather, that $15 billion burden fell on taxpayers and largely was transferred from the Pentagon’s budget.) +
++Wolf traveled to the border on October 29 to tout the progress on construction, making abundantly clear what he thought was at stake in the presidential election. He said that Biden’s policies would create a surge of migration at the border and pose a threat to national security. +
++“Let me be clear, each of those policies would endanger the lives of the border patrol and Americans across the country,” he said. +
++He also tweeted out a video jabbing at journalists who cast doubt on whether Trump would complete the border wall and whether it would even serve its intended purpose of “securing the border.” It’s not clear whether the video was produced by the Department of Homeland Security, but it might as well have been a campaign ad: +
++++They said it couldn’t be done…
+— Acting Secretary Chad Wolf (@DHS_Wolf) October 29, 2020 +
They tried to block it
They tried to spin it
They tried to hide the truth
They were wrong. 400 times and counting. pic.twitter.com/MWWP4cgoPi +
+David Lapan, a former spokesperson for DHS, called it a “misuse of [government] resources” and “clear electioneering.” +
++The announcement of Wolf’s resignation comes just before Trump’s planned trip to the US-Mexico border on Tuesday, where he is expected to again tout his legacy on immigration. +
++Historic snowfall brought Madrid to a standstill. +
++Spain is still digging itself out after the biggest snowstorm to hit the Mediterranean country in 50 years slammed the capital, Madrid, and surrounding regions over the weekend, disrupting transit and efforts to distribute coronavirus vaccines, and causing at least four deaths. +
++The bulk of the snow from Storm Filomena began falling Friday evening and left 20 inches in the capital and nearby provinces by the end of Saturday. +
++Rail service in some areas was suspended, and the New York Times reported that 12,500 miles of roads were closed or disrupted. Firefighters, members of the military, and emergency crews worked to clear runways and roads from Friday into Saturday, freeing more than 1,500 people trapped in their cars in freezing temperatures. +
++Although hundreds of roads had been cleared by Sunday and outgoing flights had resumed at the Madrid-Barajas airport, the Associated Press reported that roads in parts of the country were still largely blocked, and officials warned the country was not yet in the clear. +
++“A week of extreme cold is coming and that will transform all the snow on the ground to ice, thereby multiplying the risk,” Interior Minister Fernando Grande-Marlaska told reporters on Sunday. “The storm is bringing with it a cold wave that could push temperatures down to record levels,” he added. +
++At least four people died as a result of the storm. Two people experiencing homelessness died from exposure — one near Madrid and another in Calatayud, a city located in the country’s northeast. A woman and a man also drowned after their car was swept away in floods when a river burst close to the southern town of Malaga. +
++Government authorities on Sunday cautioned people to stay off the roads as much as possible, the AP reported, saying that although everyone trapped in their vehicles had been rescued, many abandoned vehicles remained on roadways. +
++Many Spaniards took advantage of the snow to enjoy some winter fun. On social media, scenes of Spaniards in the streets, happily engaging in mass snowball fights made the rounds. +
++++Madrid's Gran Via today was the scene of an epic snowball battle interumpted briefly by a skier who swiftly became the target #NieveInMadrid #Filomena #NevadaMadrid #Madrid #nievemadrid #snow pic.twitter.com/cGsD4Y1ig1 +
+— The Local Spain (@TheLocalSpain) January 9, 2021 +
+Some revelers were even seen skiing through Madrid’s streets. +
++++Skiing the streets of MADRID! #spain #Espana #snow #madridsnow pic.twitter.com/kNdED5x7Yb +
+— Evan Kirstel #CES2021 (@EvanKirstel) January 10, 2021 +
+Although Spanish reports predicted snow, few expected it would be so intense. +
++Rubén del Campo, a spokesperson for Spain’s government meteorological office, Aemet, told reporters that “you’d probably have to look back to the 1970s for snowfall of a similar magnitude in and around the capital.” +
++It can be incredibly difficult to pinpoint exactly what combination of factors produced this (or any) extreme weather event, but experts I spoke to said Filomena’s historic snowfall might have happened because high levels of moisture combined with temperatures that are perfect for snow, at just the right time. +
++In general, the warmer the air, the more moisture it can hold, increasing the potential for precipitation. It’s possible the air before Filomena contained more moisture and then met the “Goldilocks conditions” of about 28°F to 32°F that’s necessary for snowfall to stick on the Earth’s surface. +
++As Kevin Trenberth of the US National Center for Atmospheric Research told me, “Maximum snows occur when surface temperatures are about 28 degrees Fahrenheit and there is plenty of moisture flowing into the storm from the oceans, where moisture is abundant, and more abundant than it used to be because of global warming.” +
++In the case of Filomena, Trenberth added, “conditions were just right.” +
++That doesn’t necessarily mean climate change is directly responsible for Spain’s snowstorm, though. +
++“It isn’t possible to associate this one storm with anything directly associated with climate change,” Robinson, from Rutgers, told me. “However, having said this, there is nothing in the weather world these days where climate change doesn’t have some underlying influence on what transpires.” +
++A new Vox/DFP poll finds that most Republicans are still questioning the election results. +
++Despite the congressional certification of the presidential election results last week, an overwhelming majority of Republicans still don’t trust the outcome — and almost half don’t think that President-elect Joe Biden should be inaugurated, according to a new poll from Vox and Data for Progress. +
++In a survey fielded in the days after a group of President Donald Trump’s supporters stormed the US Capitol (January 8 to 11), 72 percent of likely Republican voters said they continue to question the presidential election results. Nearly three-quarters of Republicans, or 74 percent, said allegations of voter fraud have contributed to these concerns. Those are overwhelming majorities, but even among independents, 42 percent said they do not currently trust the election results. +
++The GOP is more split on the presidential transition, with 49 percent of Republicans saying they have doubts about the election outcome and oppose Biden’s inauguration, 29 percent saying they still have doubts about the outcome but believe Biden should be inaugurated, and 16 percent saying they trust the election results and think Biden should be inaugurated. A total of 1,233 likely voters were polled for the survey, which has a margin of error of 2.8 percentage points. +
++More broadly, Trump’s repeated unfounded allegations of election fraud appear to be affecting how people perceive the electoral system overall — not just the 2020 presidential contest. While 55 percent of people said they continue to trust the electoral process in the United States, 39 percent of people said they don’t trust it, including 65 percent of Republicans, compared to 12 percent of Democrats. +
++These findings are consistent with those in other recent surveys: A Quinnipiac poll out Monday also found that 73 percent of Republicans believe there’s widespread voter fraud, compared to 5 percent of Democrats who felt the same. +
++These results indicate that the allegations raised by Trump and his Republican allies have resonated with a large majority of the Republican base, so much so that some remain opposed to the presidential transition because of the doubts they harbor about the election results. This sharp divide in perceptions about the election outcome is also evident in how people interpreted the storming of the Capitol last week, this Vox/DFP poll finds. Such splits could have major implications for how Republican lawmakers approach policies under the incoming Biden administration, particularly if much of their base is wary of the legitimacy of his presidency. +
++People’s perceptions of the attack on the Capitol last week also differed significantly based on their party affiliation. Eighty-one percent of Democrats viewed the riot — which took place as Congress was certifying the presidential election results — as a threat to democracy, while 64 percent of independents and 47 percent of Republicans felt the same. +
++Democrats were also far more likely to say that President Donald Trump and congressional lawmakers were to blame for inciting the violence that took place at the Capitol, while Republicans were more likely to blame Democrats in Congress, President-elect Biden, and anti-fascist protesters, or antifa. As Vox’s Jerusalem Demsas reported, some conservative lawmakers began falsely blaming the violence on antifa shortly after the attacks took place last week, an explanation that appears to have caught on with some members of the party. +
++Overall, 63 percent of people blame Trump for inciting the violence, including 90 percent of Democrats and 32 percent of Republicans, and 51 percent of people blame Republican lawmakers, including 78 percent of Democrats and 25 percent of Republicans. Meanwhile, 37 percent of people blame Democratic lawmakers, including 11 percent of Democrats and 61 percent of Republicans, and 30 percent blame Biden, including 9 percent of Democrats and 53 percent of Republicans. Forty-seven percent of people blame antifa, including 29 percent of Democrats and 68 percent of Republicans. +
++Opinions regarding how lawmakers should respond to the attack also fall largely along party lines. Fifty-two percent of all people think the 25th Amendment should be invoked and Vice President Mike Pence should force Trump to step down, while 51 percent of people think Trump should be impeached. Eighty-five percent of Democrats back impeachment, while 17 percent of Republicans do. The House is poised to vote on Trump’s impeachment for the second time this week, this time charging him with inciting an insurrection. +
++As this poll makes clear, many Republicans still believe allegations of voter fraud that Trump has misleadingly raised for months, and some are even doubting the Democratic process because of them. +
+Ankita moves to final round, Ramkumar bows out of Australian Open Qualifiers - Only Nirupama Vaidyanathan and Sania Mirza have competed in the women’s singles main draw of a Grand Slam from India till date.
Aus vs Ind fourth Test | BCCI intervenes after Team India denied basic facilities in Brisbane hotel - BCCI president Sourav Ganguly, secretary Jay Shah and CEO Hemang Amin have all got in touch with their Cricket Australia counterparts.
Thailand Open: Sindhu, Praneeth lose on return to competition - No coaches, managers or other personnel are allowed to attend matches of Indian players after Saina and HS Prannoy tested positive for COVID-19.
Syed Mushtaq Ali Trophy | Kerala has it easy against Puducherry - Jalaj stifles the middle-order to claim three wickets; Sreesanth impresses on comeback
Tokyo Olympic president tries to reassure doubting country - In what was billed as a New Year's address, Mori gave a little pep talk aimed at the July 23 opening of the Olympics.
Watch | All about the bird flu outbreak in India - A video explainer on the Avian Influenza outbreak in India
DC vs MLAs again or much ado about nothing ? - Rohini Sindhuri leaves meeting of Assembly panel
54.72 lakh COVID-19 vaccine doses received till Tuesday afternoon, says Centre - A massive pan-India inoculation drive against COVID-19 was set in process with Covishield vaccine leaving Pune for 13 cities.
Manipur completes urban local bodies reforms; gets nod for ₹75 crore additional borrowing - Andhra Pradesh, Madhya Pradesh and Telangana are the other States which have undertaken urban local bodies reforms stipulated by the Department of Expenditure, Ministry of Finance.
CBI can probe LIFE Mission CEO: HC - Court dismisses petitions filed by U.V. Jose, Santhosh Eappen
Irish report to expose mother-and-baby homes cruelty - Taoiseach Micheál Martin said the findings of the report are a "shocking and difficult read".
Diary Sow: Talented Senegal student disappears in France - An investigation is opened into the disappearance of Diary Sow who has not been seen since 4 January.
Brexit leaves Spain's Costa Brits facing dilemmas - British expats in Spain tell the BBC how the new post-Brexit rules have changed their lives.
Brexit: UK driver has ham sandwiches confiscated at Dutch border - Dutch TV films officials confiscating ham sandwiches from UK drivers under new food import rules.
Beny Steinmetz: Mining tycoon in Swiss trial over Guinea deal - Billionaire Beny Steinmetz denies alleged corruption over a huge iron ore deal in Guinea.
Jared Mauch didn’t have good broadband—so he built his own fiber ISP - "I had to start a telephone company to get [high-speed] Internet access." - link
Sean Bean joins cast as the elusive Mr. Wilford in Snowpiercer S2 trailer - "The apocalypse isn't so bad, really." - link
The Codebreaker honors Quaker woman who helped bring down Nazi spy ring - Elizebeth Smith Friedman and her husband William Friedman helped pioneer cryptology. - link
Facebook says it’s blocking posts with the phrase “stop the steal” - Salesforce says it won't let Trump send out incendiary fundraising emails. - link
Parler goes dark, sues Amazon to demand immediate reinstatement - Bereft of other options, Parler is trying to petition the courts for resurrection. - link
+Henry was doing maths homework, saying to himself... +
++"2+5, the son of a bitch is 7" +
++"3+6, the son of a bitch is 9" +
++His mother heard this & asked, " Henry ! What is this nonsense you are doing?" +
++"Oh Mom. Don't disturb. I am doing my maths homework" +
++Mom: "Is this how your teacher taught you?" +
++"Yes mom " +
++Infuriated mother picked up her cell phone and called the teacher: +
++"Are you teaching maths to children by saying... 2+2, the son of a bitch is 4?" +
++There was silence for a moment +
++Then the teacher started laughing : +
++"What I taught them was... 2+2 THE SUM OF WHICH IS 4." +
+ submitted by /u/humanaura
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+...when I came downstairs, she told me she needed me to have sex with her right away... +
++Needless to say I was thrilled, so we did it right there in the kitchen... +
++...she immediately went back to cooking... we didn't usually do stuff like that, so I hesitantly asked, "so...what was that all about?" +
++She said, "I had 5 minutes left on the casserole, but the timer broke." +
+ submitted by /u/Flip_Six_Three_Hole
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+"Holy crap," the guy replies. "You actually understood and answered me!" "I got every word," says the parrot. "Ask me anything, I'll answer whatever you want." +
++"Okay," the guy says. "How can you hang onto your perch without any feet?" "Well," the parrot says, "this is very embarrassing but since you asked, I wrap my weenie around this wooden bar like a little hook. You can't see it because of my feathers." "Wow," says the guy. "You really can understand and speak English, can't you?" "Actually, I speak both Spanish and English, and I can converse with reasonable competence on almost any topic: politics, religion, sports, physics, philosophy. I'm especially good at ornithology. You really ought to buy me. I'd be a great companion." +
++The guy looks at the $200.00 price tag. "Sorry, but I just can't afford that." "Pssssssst," says the parrot, "I'm defective, so the truth is, nobody wants me cause I don't have any feet. You can probably get me for $20; just make the guy an offer!" The guy offers $20 and walks out with the parrot. Weeks go by. The parrot is sensational. He has a great sense of humor, he's interesting, he's a great pal, he understands everything, he sympathizes, and he's insightful. The guy is delighted. One day the guy comes home from work and the parrot goes, "Pssssssst," and motions him over with one wing. +
++"I don't know if I should tell you this or not, but it's about your wife and the postman." "What are you talking about?" asks the guy. "When the postman delivered the mail today, your wife greeted him at the door in a sheer black nightie." "WHAT???" the guy asks incredulously. "THEN what happened?" "Well, then the postman came into the house and lifted up her nightie and began petting her all over," reported the parrot. "NO!" he exclaims. "And she let him?" "Yes. Then he continued taking off the nightie, got down on his knees and began to kiss her all over..." Then the frantic guy demands, "THEN WHAT HAPPENED?" +
++"Damned if I know... I got a hard-on and fell off my perch!" +
+ submitted by /u/throughmethroughyou
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+The plumber comes over and quickly fixes the sink. The professor is happy until he gets the bill. He tells the plumber, "How can you charge this much? This is half of my paycheck." But he pays it anyways. +
++The plumber tells him, "Hey, we are looking for more plumbers. You could become a plumber and triple your salary. Just make sure you say you only made it to 6th grade, they don't like educated people." +
++The professor takes him up on the offer and becomes a plumber. His salary triples and he doesn't have to work nearly as hard. But the company makes an announcement that all of their plumbers must get a 7th grade education. So they all go to night school. +
++On the first day of night school they all attend math class. The teacher wants to gauge the class so he asks Dave, "What is the formula for the area of a circle?" +
++Dave walks up to the board and is about to write the formula when he realizes he has forgotten it. So he begins to attempt to derive the formula, filling the board with complicated mathematics. He ends up figuring out it is negative pi times radius squared. He thinks the minus doesn't belong so he starts over, but again he comes up with the same equation. After staring at the board for a minute he looks out at the other plumbers and sees that they are all whispering, +
++"Switch the limits on the integral!" +
+ submitted by /u/MudakMudakov
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+my neighbors are arguing about some creepy guy next door. +
+ submitted by /u/bot_10
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