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<title>04 May, 2021</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<li><a href="#from-preprints">From Preprints</a></li>
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<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
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<li><a href="#from-pubmed">From PubMed</a></li>
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<li><a href="#from-patent-search">From Patent Search</a></li>
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<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
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<li><strong>Ivermectin and the odds of hospitalization due to COVID-19: evidence from a quasi-experimental analysis based on a public intervention in Mexico City</strong> -
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Objective To measure the effect of Mexico City’s population-level intervention –an ivermectin-based Medical Kit – – in hospitalizations during the COVID-19 pandemic. Methods A quasi-experimental research design with a Coarsened Exact Matching method using administrative data from hospitals and phone-call monitoring. We estimated logistic-regression models with matched observations adjusting by age, sex, COVID severity, and comorbidities. For robustness checks separated the effect of the kit from phone medical monitoring; changed the comparison period; and subsetted the sample by hospitalization occupancy, Results We found a significant reduction in hospitalizations among patients who received the ivermectin-based medical kit; the range of the effect is 52%- 76% depending on model specification. Conclusions The study supports ivermectin-based interventions to assuage the effects of the COVID-19 pandemic on the health system.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/r93g4/" target="_blank">Ivermectin and the odds of hospitalization due to COVID-19: evidence from a quasi-experimental analysis based on a public intervention in Mexico City</a>
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<li><strong>Reframing Project Management Process Paralysis: An Autoethnographic Study of the UK Fire Service</strong> -
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The Covid-19 pandemic has created new social, environmental, and economic challenges for organisational routines, and a multilevel perspective of project management processes and decision making is required to untangle the complex nature of projects and phenomena. This research hence aims to investigate reframing of traditional project failure reasoning in pressurised situations by adopting a wider organisational view of the causation of failure using models from high-risk industries which support good decision-making practices and highlighting the project, programme and organisational structures which inherently position a project manager to fail in conditions with cognitive overload, limitations, and constraints. Through an institutional perspective, both individuals (the project managers) and organisations are considered under the influence of normative and cognitive pressures, and both are sources of change.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/hxm68/" target="_blank">Reframing Project Management Process Paralysis: An Autoethnographic Study of the UK Fire Service</a>
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<li><strong>Starch-based diet, plant-based diet or fasting may be beneficial to individuals suffering from sequelae of SARS-CoV-2 infection</strong> -
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High valine plus glycine content is a hallmark of the proteins in SARS-CoV-2 and SARS viruses, and it triggers the formation of aggregates between the two amino acid residues and calcium oxalate. As a result, SARS-CoV-2 infected individuals suffer from breathing difficulties. Human proteins with high valine plus glycine percentages can be induced during infection and these proteins may be partially retained in the body post-infection, giving rise to sequelae after disease recovery. To ameliorate such problems, starch-based diet, plant-based diet, or intermittent fasting with boiled rice water or fruit juice may be favorable to patients recovered from SARS-CoV-2 infections as they limit the intake of essential amino acids or all amino acids. Lysine supplement can be beneficial as lysine rich proteins attract chloride and solubilize insoluble and stiff calcium oxalate. However, clinical trials must be conducted to fully justify the use of lysine.
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🖺 Full Text HTML: <a href="https://osf.io/svbfy/" target="_blank">Starch-based diet, plant-based diet or fasting may be beneficial to individuals suffering from sequelae of SARS-CoV-2 infection</a>
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<li><strong>ACE2 expression in rat brain: implications for COVID-19 associated neurological manifestations</strong> -
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We examined cell type-specific expression and distribution of rat brain angiotensin converting enzyme 2 (ACE2), the receptor for SARS-CoV-2, in rodent brain. ACE2 is ubiquitously present in brain vasculature, with the highest density of ACE2 expressing capillaries found in the olfactory bulb, the hypothalamic paraventricular, supraoptic and mammillary nuclei, the midbrain substantia nigra and ventral tegmental area, and the hindbrain pontine nucleus, pre-Botzinger complex, and nucleus of tractus solitarius. ACE2 was expressed in astrocytes and astrocytic foot processes, pericytes and endothelial cells, key components of the blood-brain-barrier. We found discrete neuronal groups immunopositive for ACE2 in brainstem respiratory rhythm generating centers including the pontine nucleus, the parafascicular/retrotrapezoid nucleus, the parabrachial nucleus, the Botzinger and pre-Botzinger complex and the nucleus of tractus solitarius; in arousal-related pontine reticular nucleus and in gigantocellular reticular nuclei; in brainstem aminergic nuclei, including substantia nigra, ventral tegmental area, dorsal raphe, and locus coeruleus; in the epithalamic habenula, hypothalamic paraventricular and suprammamillary nuclei; and in the hippocampus. Identification of ACE2-expressing neurons in rat brain within well-established functional circuits facilitates prediction of possible neurological manifestations of brain ACE2 dysregulation during and after COVID-19 infection.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.01.442293v1" target="_blank">ACE2 expression in rat brain: implications for COVID-19 associated neurological manifestations</a>
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<li><strong>In silico and in vitro Demonstration of Homoharrintonine Antagonism of RBD-ACE2 Binding and its Anti-inflammatory and anti-thrombogenic Properties in a 3D human vascular lung model</strong> -
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Since 2019 the world has seen severe onslaught of SARS-CoV-2 viral pandemic. There is an urgent need for drugs that can be used to either prevent or treat the potentially fatal disease COVD-19. To this end, we screened FDA approved antiviral drugs which could be repurposed for COVID-19 through molecular docking approach in the various active sites of receptor binding domain (RBD). The RBD domain of SARS-CoV-2 spike protein is a promising drug target due to its pivotal role in viral-host attachment. Specifically, we focussed on identifying antiviral drugs which could a) block the entry of virus into host cells, b) demonstrate anti-inflammatory and/or anti-thrombogenic properties. Drugs which poses both properties could be useful for prevention and treatment of the disease. While we prioritized a few antiviral drugs based on molecular docking, corroboration with in vitro studies including a new 3D human vascular lung model strongly supported the potential of Homoharringtonine, a drug approved for chronic myeloid leukaemia to be repurposed for COVID-19. This natural product drug not only antagonized the biding of SARS-CoV-2 spike protein RBD binding to human angiotensin receptor 2 (ACE-2) protein but also demonstrated for the first time anti-thrombogenic and anti-leukocyte adhesive properties in a human cell model system. Overall, this work provides an important lead for development of rapid treatment of COVID-19 and also establishes a screening paradigm using molecular modelling and 3D human vascular lung model of disease to identify drugs with multiple desirable properties for prevention and treatment of COVID-19.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.02.442384v1" target="_blank">In silico and in vitro Demonstration of Homoharrintonine Antagonism of RBD-ACE2 Binding and its Anti-inflammatory and anti-thrombogenic Properties in a 3D human vascular lung model</a>
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<li><strong>The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro)</strong> -
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The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague the globe. The SARS-CoV-2 main protease, or Mpro, is a promising target for development of novel antiviral therapeutics. Previous X-ray crystal structures of Mpro were obtained at cryogenic temperature or room temperature only. Here we report a series of high-resolution crystal structures of unliganded Mpro across multiple temperatures from cryogenic to physiological, and another at high humidity. We interrogate these datasets with parsimonious multiconformer models, multi-copy ensemble models, and isomorphous difference density maps. Our analysis reveals a temperature-dependent conformational landscape for Mpro, including a mobile water interleaved between the catalytic dyad, mercurial conformational heterogeneity in a key substrate-binding loop, and a far-reaching intramolecular network bridging the active site and dimer interface. Our results may inspire new strategies for antiviral drug development to counter-punch COVID-19.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.03.437411v1" target="_blank">The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro)</a>
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<li><strong>SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection</strong> -
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COVID-19 is a respiratory disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes vascular-mediated neurological disorders via still elusive mechanisms. SARS-CoV-2 infects host cells by binding to angiotensin-converting enzyme 2 (ACE2), a transmembrane receptor that recognizes the viral spike (S) protein. Brain pericytes were recently shown to express ACE2 at the neurovascular interface, outlining their possible implication in microvasculature injury in COVID-19. Yet, pericyte responses to SARS-CoV-2 is still to be fully elucidated. Using cell-based assays, we report that ACE2 expression in human brain vascular pericytes is highly dynamic and is increased upon S protein stimulation. Pericytes exposed to S protein underwent profound phenotypic changes translated by increased expression of contractile and myofibrogenic proteins, namely -smooth muscle actin (-SMA), fibronectin, collagen I, and neurogenic locus notch homolog protein-3 (NOTCH3). These changes were associated to an altered intracellular calcium (Ca2+) dynamic. Furthermore, S protein induced lipid peroxidation, oxidative and nitrosative stress in pericytes as well as triggered an immune reaction translated by activation of nuclear factor-kappa-B (NF-{kappa}B) signalling pathway, which was potentiated by hypoxia, a condition associated to vascular comorbidities, which exacerbate COVID-19 pathogenesis. S protein exposure combined to hypoxia enhanced the production of pro-inflammatory cytokines involved in immune cell activation and trafficking, namely interleukin-8 (IL-8), IL-18, macrophage migration inhibitory factor (MIF), and stromal cell-derived factor-1 (SDF-1). Finally, we found that S protein could reach the mouse brain via the intranasal route and that reactive ACE2-expressing pericytes are recruited to the damaged tissue undergoing fibrotic scarring in a mouse model of cerebral multifocal micro-occlusions, a main reported vascular-mediated neurological condition associated to COVID-19. Our data demonstrate that the released S protein is sufficient to mediate pericyte immunoreactivity, which may contribute to microvasculature injury in absence of a productive viral infection. Our study provides a better understanding for the possible mechanisms underlying cerebrovascular disorders in COVID-19, paving the way to develop new therapeutic interventions.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.30.442194v1" target="_blank">SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection</a>
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<li><strong>SARS-CoV-2 Genome Sequencing Methods Differ In Their Ability To Detect Variants From Low Viral Load Samples</strong> -
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SARS-CoV-2 genomic surveillance has been vital in understanding the spread of COVID-19, the emergence of viral escape mutants and variants of concern. However, low viral loads in clinical specimens affect variant calling for phylogenetic analyses and detection of low frequency variants, important in uncovering infection transmission chains. We systematically evaluated three widely adopted SARS-CoV-2 whole genome sequencing methods for their sensitivity, specificity, and ability to reliably detect low frequency variants. Our analyses highlight that the ARTIC v3 protocol consistently displays high sensitivity for generating complete genomes at low viral loads compared with the probe-based Illumina respiratory viral oligo panel, and a pooled long-amplicon method. We show substantial variability in the number and location of low-frequency variants detected using the three methods, highlighting the importance of selecting appropriate methods to obtain high quality sequence data from low viral load samples for public health and genomic surveillance purposes.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.01.442304v1" target="_blank">SARS-CoV-2 Genome Sequencing Methods Differ In Their Ability To Detect Variants From Low Viral Load Samples</a>
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<li><strong>Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7</strong> -
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A new phase of the COVID-19 pandemic has started as several SARS-CoV-2 variants are rapidly emerging globally, raising concerns for increased transmissibility. As animal models and traditional in vitro systems may fail to model key aspects of the SARS-CoV-2 replication cycle, representative in vitro systems to assess variants phenotypically are urgently needed. We found that the British variant (clade B.1.1.7), compared to an ancestral SARS-CoV-2 clade B virus, produced higher levels of infectious virus late in infection and had a higher replicative fitness in human airway, alveolar and intestinal organoid models. Our findings unveil human organoids as powerful tools to phenotype viral variants and suggest extended shedding as a correlate of fitness for SARS-CoV-2.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.03.441080v1" target="_blank">Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7</a>
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<li><strong>Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19</strong> -
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Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflammation and pre-existing cardiovascular disease. Platelets are important mediators and sensors of inflammation and are directly affected by cardiovascular stressors. In this report, we found that platelets from severely ill, hospitalized COVID-19 patients exhibit higher basal levels of activation measured by P-selectin surface expression, and have a poor functional reserve upon in vitro stimulation. Correlating clinical features to the ability of plasma from COVID-19 patients to stimulate control platelets identified ferritin as a pivotal clinical marker associated with platelet hyperactivation. The COVID-19 plasma-mediated effect on control platelets was highest for patients that subsequently developed inpatient thrombotic events. Proteomic analysis of plasma from COVID-19 patients identified key mediators of inflammation and cardiovascular disease that positively correlated with in vitro platelet activation. Mechanistically, blocking the signaling of the Fc{gamma}RIIa-Syk and C5a-C5aR pathways on platelets, using antibody-mediated neutralization, IgG depletion or the Syk inhibitor fostamatinib, reversed this hyperactivity driven by COVID-19 plasma and prevented platelet aggregation in endothelial microfluidic chamber conditions, thus identifying these potentially actionable pathways as central for platelet activation and/or vascular complications in COVID-19 patients. In conclusion, we reveal a key role of platelet-mediated immunothrombosis in COVID-19 and identify distinct, clinically relevant, targetable signaling pathways that mediate this effect. These studies have implications for the role of platelet hyperactivation in complications associated with SARS-CoV-2 infection.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.01.442279v1" target="_blank">Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19</a>
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<li><strong>Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity</strong> -
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Tissue-resident macrophages exert critical but conflicting effects on the progression of coronavirus infections by secreting both anti-viral type I Interferons and tissue-damaging inflammatory cytokines. Steroids, the only class of host-targeting drugs approved for Covid19, indiscriminately suppress both responses, possibly impairing viral clearance, and provide limited clinical benefit. Here we set up a mouse in vitro co-culture system that reproduces the macrophage response to SARS-CoV2 seen in patients and allows quantitation of inflammatory and antiviral activities. We show that the NFKB-dependent inflammatory response can be selectively inhibited by ablating the lysine-demethylase LSD1, which additionally unleashed interferon-independent ISG activation and blocked viral egress through the lysosomal pathway. These results provide a rationale for repurposing LSD1 inhibitors, a class of drugs extensively studied in oncology, for Covid-19 treatment.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.02.441948v1" target="_blank">Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity</a>
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<li>**Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 Mice** -
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New strains of SARS-CoV-2 have emerged, including B.1.351 and P.1, that demonstrate increased transmissibility and the potential of rendering current SARS-CoV-2 vaccines less effective. A concern is that existing SARS-CoV-2 spike subunit vaccines produce neutralizing antibodies to three dimensional spike epitopes that are subject to change during viral drift. Here we provide an initial report on the hypothesis that adaptive T cell based immunity may provide a path for a pan-COVID-19 vaccine that is resilient to viral drift. T cell based adaptive immunity can be based on short peptide sequences selected from the viral proteome that are less subject to drift, and can utilize multiple such epitopes to provide redundancy in the event of drift. We find that SARS-CoV-2 peptides contained in a mRNA-LNP T cell vaccine for SARS-CoV-2 are immunogenic in mice transgenic for the human HLA-A<em>02:01 gene. We plan to test the efficacy of this vaccine with SARS-CoV-2 B.1.351 challenge trials with HLA-A</em>02:01 mice.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.02.442052v1" target="_blank">Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 Mice</a>
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<li><strong>Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals</strong> -
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Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different infectious diseases as well as healthy individuals. Here we identify 37 public clonotypes in memory B cells from convalescent survivors of SARS-CoV-2 infection or in plasmablasts from an individual after vaccination with mRNA-encoded spike protein. We identified 29 public clonotypes, including clones recognizing the receptor-binding domain (RBD) in the spike protein S1 subunit (including a neutralizing, ACE2-blocking clone that protects in vivo), and others recognizing non-RBD epitopes that bound the heptad repeat 1 region of the S2 domain. Germline-revertant forms of some public clonotypes bound efficiently to spike protein, suggesting these common germline-encoded antibodies are preconfigured for avid recognition. Identification of large numbers of public clonotypes provides insight into the molecular basis of efficacy of SARS-CoV-2 vaccines and sheds light on the immune pressures driving the selection of common viral escape mutants.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.02.442326v1" target="_blank">Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals</a>
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<li><strong>SARS -CoV-2 T-cell immunity to variants of concern following vaccination</strong> -
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Recently, two mRNA vaccines to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become available, but there is also an emergence of SARS-CoV-2 variants with increased transmissibility and virulence. A major concern is whether the available vaccines will be equally effective against these variants. The vaccines are designed to induce an immune response against the SARS-CoV-2 spike protein, which is required for viral entry to host cells. Immunity to SARS-CoV-2 is often evaluated by antibody production, while less is known about the T-cell response. Here we developed, characterized, and implemented two standardized, functional assays to measure T-cell immunity to SARS-CoV-2 in uninfected, convalescent, and vaccinated individuals. We found that vaccinated individuals had robust T-cell responses to the wild type spike and nucleocapsid proteins, even more so than convalescent patients. We also found detectable but diminished T-cell responses to spike variants (B.1.1.7, B.1.351, and B.1.1.248) among vaccinated but otherwise healthy donors. Since decreases in antibody neutralization have also been observed with some variants, investigation into the T-cell response to these variants as an alternative means of viral control is imperative. Standardized measurements of T-cell responses to SARS-CoV-2 are feasible and can be easily adjusted to determine changes in response to variants.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.03.442455v1" target="_blank">SARS -CoV-2 T-cell immunity to variants of concern following vaccination</a>
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<li><strong>“Tell me what I’m doing wrong”: Criticism of parenting choices and mental health during COVID-19</strong> -
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Objective: To explore longitudinal associations between receiving criticism about parenting choices with parental anxiety, depression, and financial worries during COVID-19. Background: During COVID-19, parents have struggled with high levels of economic insecurity, parenting stress, and mental health difficulties. Parents were also forced to make difficult parenting decisions with little evidence-based guidance. Social cognitive theory suggests that receiving criticism (i.e., negative feedback) from others can contribute to psychological distress. Methods: Data were collected via an online survey at two time points during April 2020 from a national U.S. sample of 359 parents. Quantitative analyses were conducted using logistic and linear regression, and qualitative responses were coded to elucidate topics of criticism. Results: Mothers received more parenting criticism and reported higher levels of anxiety, depression, and financial worries than fathers. The most common sources of criticism were from one’s spouse/child’s other parent (T1: 67.65%; T2: 73.86%), one’s parents (T1: 30.77%; T2: 33.33%), in-laws (T1: 23.60%; T2: 25.00%), and social media (T1: 19.54%; T2: 14.08%). Criticism about parenting choices at T1 was associated with increased parental anxiety, depression, and financial worries at T2, after controlling for these outcomes at T1. Parents were criticized for lenient parenting (20.63%) and being too strict when making decisions related to COVID-19, (18.13%), illustrating the paradox of parenting during a pandemic. Conclusion and Implications: Receiving criticism about parenting choices may exacerbate mental health problems. Parents may benefit from receiving positive feedback about their parenting, either through social media or in conversations with family members.
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🖺 Full Text HTML: <a href="https://psyarxiv.com/vp985/" target="_blank">“Tell me what I’m doing wrong”: Criticism of parenting choices and mental health during COVID-19</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Oestrogen Treatment for COVID-19 Symptoms</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Drug: Transdermal estradiol gel<br/><b>Sponsors</b>: Hamad Medical Corporation; Laboratoires Besins International<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impact of GSE and Xylitol (Xlear) on COVID-19 Symptoms and Time to PCR Negativisation in COVID-19 Patients</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Drug: GSE and Xylitol<br/><b>Sponsor</b>: Larkin Community Hospital<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19</strong> - <b>Conditions</b>: Covid19; COVID-19 Prevention<br/><b>Interventions</b>: Drug: Hydroxychloroquine (HCQ); Other: Standard care; Other: Placebo<br/><b>Sponsor</b>: Postgraduate Institute of Medical Education and Research<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate a Single Dose of LTX-109 in Subjects With COVID-19 (Coronavirus Disease 2019) Infection.</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: LTX-109 gel, 3%; Drug: Placebo gel<br/><b>Sponsors</b>: Pharma Holdings AS; Clinical Trial Consultants AB<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Clinical Trial to Evaluate the Recombinant SARS-CoV-2 Vaccine (CHO Cell) for COVID-19</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: low-dose Recombinant SARS-CoV-2 Vaccine (CHO cell); Biological: high-dose Recombinant SARS-CoV-2 Vaccine (CHO cell); Biological: placebo<br/><b>Sponsors</b>: National Vaccine and Serum Institute, China; Lanzhou Institute of Biological Products Co., Ltd; Beijing Zhong Sheng Heng Yi Pharmaceutical Technology Co., Ltd.; Zhengzhou University<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Niclosamide in Patients With COVID-19 With Gastrointestinal Infection</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Niclosamide; Drug: Placebo<br/><b>Sponsor</b>: AzurRx BioPharma, Inc.<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Immunobridging and Immunization Schedules Study of COVID-19 Vaccine (Vero Cell), Inactivated</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Biological: 3-doses schedule 1 of COVID-19 Vaccine (Vero Cell), Inactivated; Biological: 3-doses schedule 2 of COVID-19 Vaccine (Vero Cell), Inactivated; Biological: 3-doses schedule 3 of COVID-19 Vaccine (Vero Cell), Inactivated; Biological: 2 doses of vaccine<br/><b>Sponsors</b>: China National Biotec Group Company Limited; Beijing Institute of Biological Products Co Ltd.<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Selenium (as Selenious Acid); Other: Placebo<br/><b>Sponsors</b>: CHRISTUS Health; Pharco Pharmaceuticals<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Estradiol and Progesterone in Hospitalized COVID-19 Patients</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Other: Placebo injection and placebo pill; Drug: Estradiol Cypionate 5 MG/ML; Drug: Progesterone 200 MG Oral Capsule<br/><b>Sponsor</b>: Tulane University<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Detection of Covid-19 in Nasopharyngeal Swabs by Using Multi-Spectral Spectrophotometry</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Diagnostic Test: AP-23<br/><b>Sponsor</b>: Fable Biyoteknoloji San ve Tic A.S<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Vaccination Take-Up</strong> - <b>Conditions</b>: Covid19; Vaccination<br/><b>Interventions</b>: Behavioral: Financial incentives; Behavioral: Convenient scheduling link; Behavioral: Race concordant; Behavioral: Gender concordant<br/><b>Sponsors</b>: University of Southern California; Contra Costa Health Services; J-PAL North America, State and Local Innovation Initiative; National Bureau of Economic Research Roybal Center; National Institute on Aging (NIA)<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>#SafeHandsSafeHearts: An eHealth Intervention for COVID-19 Prevention and Support</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Behavioral: eHealth for Covid-19 prevention and support<br/><b>Sponsor</b>: University of Toronto<br/><b>Recruiting</b></p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Demi-dose of Two Covid-19 mRNA Vaccines in Healthy Population</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Diagnostic Test: immunogenicity after first and second dose<br/><b>Sponsors</b>: Sciensano; Mensura EDPB; Institute of Tropical Medicine, Belgium; Erasme University Hospital<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Remdesivir Efficacy In Management Of COVID-19 Patients</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Remdesivir; Drug: Standard of care_1; Drug: Standard of care_2<br/><b>Sponsor</b>: Ain Shams University<br/><b>Completed</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Niclosamide; Drug: Placebo<br/><b>Sponsors</b>: Cambridge University Hospitals NHS Foundation Trust; LifeArc; Kidney Research UK (KRUK); UNION therapeutics; Addenbrookes Charitable Trust<br/><b>Recruiting</b></p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
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<ul>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Complement inhibition in severe COVID-19 - Blocking C5a seems to be key: Author’s reply</strong> - No abstract</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses</strong> - Type I interferons (IFNs) are our first line of defence against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production is associated with manifestation of COVID-19 severity. In spite of progress in understanding how SARS-CoV-2 activates antiviral responses, mechanistic studies into wildtype SARS-CoV-2-mediated induction and inhibition of human type I IFN responses are scarce….</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019</strong> - Although immune dysfunction is a key feature of coronavirus disease 2019 (COVID-19), the metabolism-related mechanisms remain elusive. Here, by reanalyzing single-cell RNA sequencing data, we delineated metabolic remodeling in peripheral blood mononuclear cells (PBMCs) to elucidate the metabolic mechanisms that may lead to the progression of severe COVID-19. After scoring the metabolism-related biological processes and signaling pathways, we found that mono-CD14^(+) cells expressed higher levels…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights</strong> - CONCLUSION: Entheseal pDCs link microbes to TNF/IFNα production. SARS-CoV-2 infection is associated with PsA Flares and JAK inhibition suppressed activated entheseal plasmacytoid dendritic Type-1 interferon responses as pointers towards a novel mechanism of PsA and SpA-related arthropathy.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>From Resilience to Burnout in Healthcare Workers During the COVID-19 Emergency: The Role of the Ability to Tolerate Uncertainty</strong> - The COVID-19 outbreak has placed extraordinary demands upon healthcare systems worldwide. Italy’s hospitals have been among the most severely overwhelmed, and as a result, Italian healthcare workers’ (HCWs) well-being has been at risk. The aim of this study is to explore the relationships between dimensions of burnout and various psychological features among Italian healthcare workers (HCWs) during the COVID-19 emergency. A group of 267 HCWs from a hospital in the Lazio Region completed…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Na(+)/K(+)-ATPase as a Target of Cardiac Glycosides for the Treatment of SARS-CoV-2 Infection</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified for the first time in Wuhan, China, causes coronavirus disease 2019 (COVID-19), which moved from epidemic status to becoming a pandemic. Since its discovery in December 2019, there have been countless cases of mortality and morbidity due to this virus. Several compounds such as chloroquine, hydroxychloroquine, lopinavir-ritonavir, and remdesivir have been tested as potential therapies; however, no effective treatment is…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studies</strong> - The human-to-human transmitted respiratory illness in COVID-19 affected by the pathogenic Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), which appeared in the last of December 2019 in Wuhan, China, and rapidly spread in many countries. Thereon, based on the urgent need for therapeutic molecules, we conducted in silico based docking and simulation molecular interaction studies on repurposing drugs, targeting SARS-CoV-2 spike protein. Further, the best binding energy of doxorubicin…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Modelling studies reveal the importance of the C-terminal inter motif loop of NSP1 as a promising target site for drug discovery and screening of potential phytochemicals to combat SARS-CoV-2</strong> - COVID-19 pandemic causative SARS-CoV-2 coronavirus is still rapid in progression and transmission even after a year. Understanding the viral transmission and impeding the replication process within human cells are considered as the vital point to control and overcome COVID-19 infection. Non-structural Protein 1, one among the proteins initially produced upon viral entry into human cells, instantly binds with the human ribosome and inhibit the host translation process by preventing the mRNA…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bile acids LCA and CDCA inhibited porcine deltacoronavirus replication in vitro</strong> - Porcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus that causes gastroenteritis in pigs and no vaccines or antiviral drugs are available. Bile acids are active factors in intestines and influence the replication of enteric viruses. Currently, the role of bile acids on PDCoV replication is unknown. In this study, we tested the effects of different types of bile acids on the replication of PDCoV in cell culture. We found that physiological concentrations of bile acids…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reconstitution and functional characterization of SARS-CoV-2 proofreading complex</strong> - The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) has led to a world-wild pandemic. The replication of SARS-CoV-2 RNA genome involves the core replication-transcription complex (RTC, nsp12-nsp7-nsp8) and the proofreading complex (nsp14-nsp10) that can correct mismatched base pairs during replication. Structures and functions of SARS-CoV-2 RTC have been actively studied, yet little is known about SARS-CoV-2 nsp14-nsp10. Here, we purified, reconstituted, and…</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Endothelin Antagonism and Sodium Glucose Co-transporter 2 Inhibition A Potential Combination Therapeutic Strategy for COVID-19</strong> - The novel coronavirus 2019 (COVID-19) infection caused by SARS-CoV-2 is a global pandemic that requires a multi-faceted approach to tackle this unprecedent health crisis. Therapeutics to treat COVID-19 are an integral part of any such management strategy and there is a substantial unmet need for treatments for individuals most at risk of severe disease. This perspective review provides rationale of a combined therapeutic regimen of selective endothelin-A (ET-A) receptor antagonism and sodium…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus</strong> - Feline infectious peritonitis (FIP) is a fatal systemic disease of felids caused by a Coronavirus (CoV) (FIPV). In spite of its clinical relevance and impact on feline health, currently the therapeutic possibilities for treatment of FIP in cats are limited. The emergence of the pandemic Severe Respiratory Syndrome (SARS) coronavirus (CoV) type 2 (SARS-CoV-2), etiological agent of the 2019 Coronavirus Disease (COVID-19), able to infect a broad spectrum of animal species including cats, triggered…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The systemic pro-inflammatory response: targeting the dangerous liaison between COVID-19 and cancer</strong> - Inflammation is an established driver of severe SARS-CoV-2 infection and a mechanism linked to the increased susceptibility to fatal COVID-19 demonstrated by patients with cancer. As patients with cancer exhibit a higher level of inflammation compared with the general patient population, patients with cancer and COVID-19 may uniquely benefit from strategies targeted at overcoming the unrestrained pro-inflammatory response. Targeted and non-targeted anti-inflammatory therapies may prevent…</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro</strong> - Since the beginning of December 2019, a novel Coronavirus severe respiratory disease, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which also been termed 2019-new CoV (2019-nCoV), has continued to spread worldwide. As of August 27, 2020, a total of 24,232,429 people have been infected and 826,518 people have died. In our study, we found that astemizole can antagonize ACE2 and inhibit the entry of SARS-COV-2 spike pseudovirus into ACE2-expressed HEK293T cells (ACE2hi…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule</strong> - LianhuaQingwen capsule, prepared from an herbal combination, is officially recommended as treatment for COVID-19 in China. Of the serial pharmacokinetic investigations we designed to facilitate identifying LianhuaQingwen compounds that are likely to be therapeutically important, the current investigation focused on the component Glycyrrhiza uralensis roots (Gancao). Besides its function in COVID-19 treatment, Gancao is able to induce pseudoaldosteronism by inhibiting renal 11β-HSD2. Systemic and…</p></li>
|
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|
</ul>
|
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|
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
|
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<ul>
|
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A COMPREHENSIVE DISINFECTION SYSTEM DURING PANDEMIC FOR PERSONAL ITEMS AND PROTECTIVE EQUIPMENT (PPE) TO SAFEGUARD PEOPLE</strong> - The current Covid-19 pandemic has led to an enormous demand for gadgets / objects for personal protection. To prevent the spread of virus, it is important to disinfect commonly touched objects. One of the ways suggested is to use a personal UV-C disinfecting box that is “efficient and effective in deactivating the COVID-19 virus. The present model has implemented the use of a UV transparent material (fused silica quartz glass tubes) as the medium of support for the objects to be disinfected to increase the effectiveness of disinfection without compromising the load bearing capacity. Aluminum foil, a UV reflecting material, was used as the inner lining of the box for effective utilization of the UVC light emitted by the UVC lamps. Care has been taken to prevent leakage of UVC radiation out of the system. COVID-19 virus can be inactivated in 5 minutes by UVC irradiation in this disinfection box - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN322882412">link</a></p></li>
|
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|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USE OF IMINOSUGAR COMPOUND IN PREPARATION OF ANTI-SARS-COV-2 VIRUS DRUG</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU322897928">link</a></p></li>
|
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU321590214">link</a></p></li>
|
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|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD FOR QUANTIFICATION OF PIRFENIDONE, A COVID-19 ANTI-FIBROTIC AGENT, BY SENSITIVE ANALYTICAL TECHNIQUES</strong> - This invention relates to the development of specific methods for quantification of pirfenidone, an anti-fibrotic drug which is used to treat Covid-19 for curing lung infections. Ultra-Violet spectroscopy detection and quantification conducted using HPLC grade water as solvent. Linearity constructed for the concentration range of 3-15µL for UV spectroscopy, 2-10 µg/ml for HPLC using methanol as diluent and 5-25µg/ml using methanol as diluent for HPTLC. The chromatographic system comprised of HPLC system equipped with quaternary gradient pump and Shim-Pack GIST C18 (250X 4.6 mm, 5µm) column with PDA detector monitored at 310nm. HPTLC performed on silica gel 60 F254 plates using mobile phase in the ratio of toluene and methanol 8:2 v/v. Analytical method validation done according to ICH Q2 (R1) guidelines. System suitability, intraday precision and inter day precision calculations performed and reported which found to be within limits (%RSD<2%). Recovery studies performed and amount recovered is found between 98.20-102.20%. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN322881663">link</a></p></li>
|
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>5-(4-TERT-BUTOXY PHENYL)-3-(4N-OCTYLOXYPHENYL)-4,5-DIHYDROISOXAZOLE MOLECULE (C-I): A PROMISING DRUG FOR SARS-COV-2 (TARGET I) AND BLOOD CANCER (TARGET II)</strong> - The present invention relates to a method ofmolecular docking of crystalline compound (C-I) with SARS-COV 2 proteins and its repurposing with proteins of blood cancer, comprising the steps of ; employing an algorithmto carry molecular docking calculations of the crystalized compound (C-I); studying the compound computationally to understand the effect of binding groups with the atoms of the amino acids on at least four target proteins of SARS-COV 2; downloading the structure of the proteins; removing water molecules, co enzymes and inhibitors attached to the enzymes; drawing the structure using Chem Sketch software; converting the mol file into a PDB file; using crystalized compound (C-I) for comparative and drug repurposing with two other mutated proteins; docking compound into the groove of the proteins; saving format of docked molecules retrieved; and filtering and docking the best docked results. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN320884617">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>新闻传播速度测评方法和系统</strong> - 本发明实施例提供一种新闻传播速度测评方法和系统，核心是基于新闻媒体权重计算新闻事件主题的传播速度，再通过聚类分析确定传播速度测评体系，最后评定新闻事件主题的传播等级。其中方法包括：确定待测评的新闻事件主题，获取新闻事件主题的新闻数据；基于新闻数据中每一新闻文本的传播媒体信息，计算新闻事件主题的初始传播速度；基于初始传播速度，以及预先设定的传播速度测评体系，确定新闻事件主题的传播速度等级；其中，传播速度测评体系包括多个传播速度等级与初始传播速度之间的对应关系。本发明实施例提供的方法和系统，实现了基于大数据的新闻事件舆情监测，能够有效提高新闻事件舆情响应效率，有利于决策管理者及时做出舆情应对。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN322592921">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AQUEOUS ZINC OXIDE NANOSPRAY COMPOSITIONS</strong> - Disclosed herein is aqueous zinc oxide nano spray compositions comprising zinc oxide nanoparticles and a synthetic surfactant for controlling the spread of Covid-19 virus. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN321836709">link</a></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bettverlängerungssystem</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Bettverlängerungssystem (1) für in Bauchlage beatmungspflichtige Patienten in Gestalt mit zumindest einer Platte (16), dadurch gekennzeichnet, dass die Platte (16) im Kopflagerungsbereich einen Luftwegezugangsdurchbruch (8) mit einem den Luftwegezugangsdurchbruch (8) umgebenden Auflagerbereich für ein durchbrochenes Kopfauflagepolster (14) aufweist, durch den von der Bettunterseite her und durch das Kopfauflagepolster (14) hindurch die Ver- und Entsorgungsschläuche für eine orotracheale Intubation oder eine nasotracheale Intubation ventral an das Gesicht des Patienten herangeführt werden können, und dass die Platte (16) im Bereich ihrer dem Kopfende eines Bettrosts (15) zugeordneten Stirnseite (6) ein Fixierelement (2) zur Befestigung der Platte (16) am Bettrost (15) nach Art eines einseitig frei über das Kopfende des Bettrosts hinausragenden Kragträgers aufweist.</p></li>
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</ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE322212040">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种肝素类药物组合物、喷鼻剂及其制备方法及应用</strong> - 本发明公开了一种肝素类药物组合物、喷鼻剂及其制备方法及应用。该肝素类药物组合物包括肝素钠和阿比朵尔。本发明中的肝素类药物组合物首次采用肝素钠和阿比朵尔联合使用，普通肝素钠联合1μM/L以上的阿比朵尔病毒抑制效率显著高于单独普通肝素钠或单独阿比多尔组（p<0.05）。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN321712860">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USING CLINICAL ONTOLOGIES TO BUILD KNOWLEDGE BASED CLINICAL DECISION SUPPORT SYSTEM FOR NOVEL CORONAVIRUS (COVID-19) WITH THE ADOPTION OF TELECONFERENCING FOR THE PRIMARY HEALTH CENTRES/SATELLITE CLINICS OF ROYAL OMAN POLICE IN SULTANATE OF OMAN</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU320796026">link</a></p></li>
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<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-new-yorker">From New Yorker</a></li>
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<li><a href="#from-vox">From Vox</a></li>
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<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
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<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
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<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
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<li><a href="#from-ars-technica">From Ars Technica</a></li>
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<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
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</ul>
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<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
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<ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kathryn Garcia Doesn’t Want Andrew Yang’s Praise</strong> - The city-government veteran and mayoral hopeful talks about management, wastewater, and the viability trap. - <a href="https://www.newyorker.com/news/our-local-correspondents/kathryn-garcia-doesnt-want-andrew-yangs-praise">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Facebook and the Normalization of Deviance</strong> - The trouble with waiting to address problems long after you know that they exist. - <a href="https://www.newyorker.com/news/daily-comment/facebook-and-the-normalization-of-deviance">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Joe Biden, the Republicans, and Kids’ Stuff</strong> - As the new Administration enters its next hundred days, the child wars are likely to grow more intense and, in some quarters, more detached from reality. - <a href="https://www.newyorker.com/magazine/2021/05/10/joe-biden-the-republicans-and-kids-stuff">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biden’s Great Economic Rebalancing</strong> - The President is looking to correct a capitalist economy that has gone askew, and reclaim a lost vision of shared prosperity. - <a href="https://www.newyorker.com/news/our-columnists/joe-bidens-great-economic-rebalancing">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Surviving the Crackdown in Xinjiang, in Mandarin</strong> - The New Yorker translates its recent report on China’s mass internment of Uyghurs and Kazakhs. - <a href="https://www.newyorker.com/news/news-desk/surviving-the-crackdown-in-xinjiang-in-mandarin">link</a></p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
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<li><strong>Reality TV used to be about getting famous. 90 Day Fiancé is about the American dream.</strong> -
|
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<figure>
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<img alt="A couple embraces and looks at the camera, against a colorful backdrop." src="https://cdn.vox-cdn.com/thumbor/YS3ezu_4gx8hVd3oKvwQbans_R8=/52x0:1193x856/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69233496/90_Day_Fiance.0.jpeg"/>
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<figcaption>
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Jorge and Anfisa, from the fourth season of <em>90 Day Fiancé.</em> | TLC
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</figcaption>
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</figure>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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The sprawling TLC franchise changed the game in reality TV.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X4rlK4">
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When you stop to think about it, reality TV and documentaries are cousins, if not siblings. The family resemblance may seem unlikely, but it’s there. Both documentaries and reality shows use the raw material of “real life,” then selectively edit and craft a narrative that’s funny or thrilling or dramatic, with characters, stakes, and something to tell us about ourselves. You might even say that documentary walked so that reality TV could fly — or vice versa?
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DgXiqI">
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That link is something that writer, critic, and comedian Ashley Ray-Harris has been thinking about a lot. A connoisseur of reality TV of all kinds, she writes for outlets like <a href="https://www.vulture.com/author/ashley-ray-harris/">Vulture</a> and the <a href="https://tv.avclub.com/author/ashleyrayharris">AV Club</a> — including a lot about <a href="https://www.vulture.com/article/90-day-fiance-how-to-watch-franchise-guide.html">the TLC show <em>90 Day Fiancé</em></a> — as well as <a href="https://ashleyray.substack.com/">her own newsletter</a><em>. </em>And her weekly podcast <a href="https://theashleyray.com/tvisaypod"><em>TV, I Say with Ashley Ray</em></a> is a wide-ranging exploration of the medium, often with fun special guests. (When it was time to talk <em>90 Day Fiancé</em>, <a href="https://www.buzzsprout.com/1395490/6788944-ep-8-roxane-gay-and-seth-rogen-in-conversation-90-day-fiance">she chatted with Seth Rogen and Roxane Gay</a>.)
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y4ZDXZ">
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So it makes sense that Ray-Harris was asked by the <a href="https://truefalse.org/">True/False Film Festival</a> — one of the premier all-documentary festivals in the US — to curate this year’s “Neither/Nor” section, an exploration of the margins of documentary. The program will be available for free online from May 5 through May 9 and will focus on shifts in reality TV and how its “constructed reality” functioned during the Trump era. Viewers can watch episodes of <em>90 Day Fiancé </em>and read Ray-Harris’s writing on the subject, all <a href="https://truefalse.org/program/neither-nor/">collected on the True/False website</a> beginning May 5.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nUMwan">
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I am a longtime True/False fan and someone who thinks about nonfiction filmmaking a lot. So I was fascinated when I heard about this year’s program, especially because I’ve only dipped my toes into reality TV. So I watched a few episodes of <em>90 Day Fiancé </em>(which bucked my expectations, in a good way) and then called Ray-Harris to talk about why she loves the reality empire <em>90 Day Fiancé</em> has spawned, the way Donald Trump changed reality TV, the relationship between reality TV and documentary filmmaking, and more.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o22TWA">
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<strong>You’ve watched a lot of reality TV and docuseries. Why do you think </strong><em><strong>90 Day Fiancé </strong></em><strong>is so important?</strong>
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0mI2yD">
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<em>90 Day Fiancé</em> is one of the most pivotal reality shows. From when it debuted in 2014 to now, you actively get to see it react to the culture. You see it react to ICE and immigration under Trump; that impacts and changes the show. It became so popular — to the point where you get all of these spinoffs [of which there are now nearly a dozen] — because people recognized it as not being a product of the early 2000s Trump/Kardashian reality machine, which is losing steam.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eT8mCf">
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When it comes to the reality shows like <em>The Apprentice, </em>the shows that made people like Trump — this idea that you could have someone pick you up and lift you out of poverty and make it as a reality star — I think today we see that reality as false. You can get famous being on Instagram, being on TikTok, being on Twitter, but the idea that you can even go on reality TV to get famous nowadays feels so false. The cast and crew of <em>90 Day Fiancé</em> — sure, people know them and follow their lives outside of the show. But they wouldn’t call themselves celebrities. We don’t see them as the type of celebrity that you saw created with shows like <em>Laguna Beach</em>.
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<aside id="VcZqv5">
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<q>“Viewers have become more focused on whether what they’re watching is ethical”</q>
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</aside>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D5NDgF">
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That’s created this really interesting conundrum for producers. With some reality shows, things like <em>My 600-Pound Life</em>, <em>Intervention</em>, <em>Hoarders</em> — there’s always been the question of how exploitative they are. How much are we using these people? This isn’t manufactured like <em>Real Housewives </em>of whatever; this is people’s real lives.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="N0G5ZQ">
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In the early days of <em>90 Day Fiancé,</em> like in season two, there’s some fairly exploitative TV. There are moments when you’re like, “Someone please help this 19-year-old girl who is about to marry a 50-year-old, please!” Or with [<em>90 Day Fiancé</em> couple] <a href="https://screenrant.com/90-day-fiance-danielle-mohamed-season-2/">Danielle and Mohammed</a>, where it’s so clearly a manipulative, abusive relationship on both ends.
|
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</p>
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<figure class="e-image">
|
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|
<img alt="A young man and a middle-aged woman stand in a garden." src="https://cdn.vox-cdn.com/thumbor/XWZn7XaQ-4g6l1h89eMdwuI55t8=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22489339/danielle_mohamed2.jpeg"/> <cite>TLC</cite>
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|
<figcaption>
|
||||||
|
Mohamed and Danielle, whose engagement plays out in season two of <em>90 Day Fiancé.</em>
|
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|
</figcaption>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DbyXIM">
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But <em>90 Day Fiancé</em> is one of the rare shows that, when called out, has said, “Okay, yeah.” You shouldn’t call ICE on these people who are coming here for love. We’ll paint the American as the villain, rather than always siding with the American, or always siding with whoever American society might say is the hero for falling in line with the American dream.
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<strong>I had not watched </strong><em><strong>90 Day Fiancé </strong></em><strong>at all until recently, but when I dipped into it I discovered that it’s not just a show, it’s like an entire universe.</strong>
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A whole universe! I wrote <a href="https://www.vulture.com/article/90-day-fiance-how-to-watch-franchise-guide.html">a guide on how to watch it</a>. On Discovery+, there’s <a href="https://screenrant.com/discovery-plus-90-day-fiance-property-brothers-channels/">a <em>90 Day Fiancé</em> “channel,”</a> where you can just hop in and follow one couple if you want. You can just watch all of the <a href="https://www.imdb.com/title/tt13990474/"><em>90 Day: The Single Life</em></a> spinoffs. They call it their own Marvel Universe. At this point, they’ve got 11 spinoffs.
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<strong>It’s so much to absorb! But the concept of the whole franchise is also really simple. It’s different from some reality shows I’ve seen — </strong><em><strong>Real Housewives</strong></em><strong>, </strong><em><strong>The Apprentice</strong></em><strong>, that sort of thing. One thing that struck me while I watched </strong><em><strong>90 Day Fiancé</strong></em><strong> was how much it felt like a documentary. If you told me the show was just a documentary about people who are going through this specific visa process, rather than a “reality show,” I completely would have believed you. </strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LlSDTK">
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<strong>I think some of that comes from the filmmaking. But some of it also comes from what it expects us to feel as we watch it. </strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rVehIW">
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That is the thing that shocks people the most. When people first hear about <em>90 Day Fiancé</em>, they’re like, “Okay, is it some sort of competition? Is it some sort of thing where people have to fall in love in 90 days?”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CEirus">
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<strong>That’s what I thought at first.</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="esFP7U">
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Then you start watching and you realize that these are people who already loved each other and would be doing this without the show. They aren’t making their decisions because they want to be on a TV show — most of them, anyhow. In the later seasons, with some of them, you’re definitely like, “Okay, this person just wanted to be on TV.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YSn7Nc">
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<strong>There’s always a moment on a long-running reality show when you can feel the show becoming self-aware, because the people on the show now were watching the show before they were cast. </strong>
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Mx2nlE">
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Yes. But with the <em>90 Day Fiancé</em> universe, because the show kind of peeks in at different moments [in couples’ lives], that doesn’t really happen. You see them go through the visa process, and then you might not see that couple again until three years later, when they’re on <em>90 Day Fiancé: Happily Ever After</em>. That gives it a more natural feeling — “I’m checking in on this family that I like, and they got married, and now they have three kids.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5fmYsh">
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That kind of self-awareness can really go wrong. An example is the <a href="https://popculture.com/reality-tv/news/teen-mom-every-16-and-pregnant-spinoff-ever/"><em>Teen Mom</em></a> franchise. [<em>Teen Mom</em> is a spinoff from MTV’s <em>16 and Pregnant</em>; both launched in 2009. <em>Teen Mom</em> now has four spinoffs of its own.] When the franchise first started, it was about 16-year-old girls who were going through stuff they’d never been through before. It was messy, and it was about their lives.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q5BgK3">
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But by the fifth season of <em>Teen Mom</em>, they’re girls who grew up watching reality TV and who understand how to manipulate the producers just as much as they’ve been manipulated. On top of that, their children, who grew up on camera since they were on<em> 16 And Pregnant</em>, understand being on camera. You see these kids talking to the producers like they’re family members. The show becomes so much more staged. They understand how they should act on camera versus off camera. They start to understand their double consciousness.
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</p>
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<div class="c-float-right">
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<aside id="p1R5Ij">
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<q>“If America is a melting pot, <em>90 Day Fiancé</em> is when it reaches its boiling point”</q>
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</aside>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BbK30Q">
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With <em>90 Day Fiancé</em>, the producers are very good about allowing the people on the show to have boundaries in their lives. A lot of the people on the show do get into legal trouble or have personal issues. But the show is very clear that that’s not what it’s about; it’s about exploring the K1 visa process. It’s about exploring the idea and promise of the American dream, and what we make of it.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h54CAp">
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That’s why it’s so good at showing that the American dream isn’t all it’s cracked up to be. It’s a show that says, “Yeah, people think America is great. And then they get here and they realize, Oh, now I live in Kentucky and we don’t have clean water. What is this place? We can’t even afford an apartment!” It’s unflinching and doesn’t really try to paint a better picture. I give it a lot of credit for that.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ksl81o">
|
||||||
|
I think that’s why it does feel so much like a documentary, and why it has influenced documentary makers. In some ways, it elevates the genre of reality TV. If America is a melting pot, <em>90 Day Fiancé</em> is when it reaches its boiling point, where you see it all come together. They somehow managed to find a way to spin that off into 11 different versions of that stew, and they all taste great.
|
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IO6CNZ">
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|
<strong>When I watch the more Bravo-style reality shows, I know that when I’m watching, they don’t really want you to empathize with anyone. At best there’s a character you might root for. But </strong><em><strong>90 Day Fiancé </strong></em><strong>definitely feels like it’s attempting to help you understand all the characters, to feel what it’s like to be them in this position.</strong>
|
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E6PtQH">
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Yes. In the end, it’s a show about people who want love — who in some cases desperately want love — which puts people in this really vulnerable position. And somehow the producers and makers of the show find a way to treat it with such empathy and sympathy. You want these people to find the love they want. When they’re with people who you know they shouldn’t be with, you’re not like, “Oh, this is gonna be good drama.” Instead, you’re just like, “No girl, you deserve better. Don’t date him. Don’t marry him. You should have someone else.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mShXAp">
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It’s never a facetious thing, even when it’s like [<em>90 Day Fiancé: Before the 90 Days s</em>eason two’s] Angela and Michael — and I mean, those two have so many issues. Angela is a white woman from Georgia. Michael is her Nigerian lover. I think they’re probably one of the most famous examples from the show of how twisted American exceptionalism can be.
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||||||
|
Michael proudly says, “I’m a Trump supporter! I want to go to America.” Angela is like, “He’s my Nigerian king. How can I be racist when I have him?” If I just was reading about them, I would be like, “What is happening here? What is this?”
|
||||||
|
</p>
|
||||||
|
<div class="c-float-right">
|
||||||
|
<aside id="JeTyvi">
|
||||||
|
<q>“This is about how people love, what people are afraid of and love, how people change, how people grow”</q>
|
||||||
|
</aside>
|
||||||
|
</div>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Igxes">
|
||||||
|
And then when you watch their story, and you see Michael <em>does</em> love her. They have real issues — she’s too old to have a child, they’re not sure if they’ll be able to surrogate. It’s way more empathetic than if it was just this Black guy who clearly has some internalized issues with racism and is trying to just get a visa. It’s about so much more.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SpLmEV">
|
||||||
|
It’s about how he is going to carry on his legacy and honor his family when he knows he really does love this American woman. It just warms your heart, even though on paper, you’d be like, “Oh, my God, this is terrible, it’s exploitative, and these people shouldn’t be together<em>.”</em> But then when you watch it, you’re like, “Oh, my gosh, no, Michael really does just want to help Angela take care of her horde of grandkids. That is his dream.”
|
||||||
|
</p>
|
||||||
|
<figure class="e-image">
|
||||||
|
<img alt="A white woman and a Black man smile." src="https://cdn.vox-cdn.com/thumbor/mhtprhLuA-sUkEzd4HOk8p6x3MM=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22489343/angelamichael.jpg"/> <cite>TLC</cite>
|
||||||
|
<figcaption>
|
||||||
|
Angela and Michael, who first appear in <em>90 Day Fiancé: Before the 90 Days</em>,<em> s</em>eason two.
|
||||||
|
</figcaption>
|
||||||
|
</figure>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OJ9OSp">
|
||||||
|
<strong>Several people in the documentary world have told me that reality TV — particularly early shows like </strong><em><strong>The Real World</strong></em><strong> — taught people how to watch documentaries.</strong>
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Cox4ua">
|
||||||
|
I really think that that is true. There’s a phenomenon going on recently: We are seeing fewer documentary movies and more four- and five-part documentary series. And in some cases it’s warranted. When it’s something like <a href="https://www.vox.com/culture/2020/10/21/21525430/vow-finale-nxivm-interview-explained-raniere-noujaim-amer"><em>The Vow</em></a> and <em>Seduced</em>, series that get into deep topics, people don’t just want to sit down for an hour and a half. With episodes, people feel as though they’re getting more information, they’re getting more in-depth, they’re getting a whole episode about this person’s background story versus just the first 10 minutes of a film.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Drtn0Z">
|
||||||
|
And I think that mirrors how people watch reality TV shows. I never was a big fan of <em>The Real Housewives</em> and other shows like that because there’s no longevity. You don’t need to know what happened the previous season to care about what is happening in these people’s lives, because really, it has nothing to do with their real lives. Whereas with <em>90 Day Fiancé</em>, you have to know what happened in their lives before the show to see how they got there. You grow with them.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X9cXJY">
|
||||||
|
I think we’ve seen that mirrored in the documentary space, where people realize you can allow more space for empathy. There’s a template people expect for documentary movies — this is what this is about, and by this point, I should have this type of closure. When it’s more open-ended, you don’t get forced into that box. With series like <em>Murder on Middle Beach</em>,<em> Heaven’s Gate</em>,<em> </em>and<em> </em><a href="https://www.vox.com/culture/21417306/love-fraud-interview-review-showtime-ewing-grady"><em>Love Fraud</em></a>, they focus on empathy for the victims. They get into the villain, but without making it the villain’s story.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OvDIYK">
|
||||||
|
And viewers have gotten more used to that because we’ve seen reality documentary series on TV change. Shows like <em>Hoarders</em> and <em>Intervention</em> have also grown. I’ve been obsessed with <em>Hoarders</em> since it first came on the air. People would be like, “How can you watch that show? It’s so exploitative. You know, they’re just making fun of these people with horrible homes.” But now they show you every step of the process: bringing in the family, the psychiatrists, the aftercare help that they get.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2cav94">
|
||||||
|
Viewers have become more focused on whether what they’re watching is ethical. Is what I’m watching fair? Is what I’m watching giving me two sides of a story, or is it just trying to get me to root for a plot, or some sort of overall villain or story? I think reality TV has had a huge impact on that.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F0d0f7">
|
||||||
|
And I love where we are in the documentary age. I am constantly just seeing new things I’m excited about. I kind of wish we could go back and redo some of my favorite documentaries as four-part series, because you just get so much more.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8U6Sxv">
|
||||||
|
<strong>Okay, so: Tell me how this True/False program about </strong><em><strong>90 Day Fiancé</strong></em><strong> came together.</strong>
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r2zMsw">
|
||||||
|
I’ve been such a fan of this festival and their programming for a long time. When my friend Amir [George, one of the festival’s programmers], first hit me up, he was like, “Ashley, we want to do something really different this year.”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HsazHD">
|
||||||
|
And I was like, “First of all, what do you want from me? Because I’m a TV person.” He said they wanted to look at the current surge of reality TV and how it’s changed over the last four years because of Trump, and the ways reality TV is starting to mirror documentary filmmaking. That was something that I had also seen.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7ZxplP">
|
||||||
|
So I thought we could do an in-depth look at reality TV, and specifically<em> 90 Day Fiancé</em>. At how we’ve seen that exploration of exploitation influence not just reality TV, but also docuseries and true crime, with more people saying, “<a href="https://www.vox.com/culture/22272863/redhanded-true-crime-podcast-interview-hosts-suruthi-bala-hannah-maguire">Let’s focus on victims’ stories</a>. Let’s focus on <a href="https://www.vox.com/culture/22240673/netflix-night-stalker-docuseries-frank-salerno-gil-carrillo">the untold stories</a> rather than focusing <a href="https://www.vox.com/22258961/netflix-the-ripper-review-yorkshire-ripper-documentary">on the murderer</a> or the serial killer or the victor.”
|
||||||
|
</p>
|
||||||
|
<figure class="e-image">
|
||||||
|
<img alt="Two men stand and smile at the camera." src="https://cdn.vox-cdn.com/thumbor/Tbb2UsjUmfrkwad3Ic_WOdyYDi4=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22489348/kennetharmando.jpg"/> <cite>TLC</cite>
|
||||||
|
<figcaption>
|
||||||
|
Kenneth and Armando, the franchise’s first gay male couple, who appeared on <em>90 Day Fiancé: The Other Way.</em>
|
||||||
|
</figcaption>
|
||||||
|
</figure>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cx9HkN">
|
||||||
|
<strong>So for people who might watch the program, since it’s online, what will they experience?</strong>
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wi3AYs">
|
||||||
|
We’ll be exploring how <em>90 Day Fiancé</em> has not only changed in the time it’s been on TV, but how it’s impacted the culture of documentary making, as well as the current reality TV landscape. How it became a ratings juggernaut, a powerful thing that could set the tone for the reality TV landscape.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qSsQKV">
|
||||||
|
And we’ll look at why it’s doing that in a positive way that gives us more reality, more capability, more empathy, than previous generations of reality TV like <a href="https://www.vox.com/culture/22338679/keeping-up-with-the-kardashians-final-season-20-hulu">the Kardashian era</a> — or as I like to call it, the “fake it till you make it” era. Everyone knew Donald Trump had been bankrupt, but <em>The Apprentice</em> made some people believe, “No, he’s a legit businessman, he knows business.” That’s not true. The Kardashians weren’t actually a conglomerate family that’s done all these things — but now it is true, because they faked it until they made it.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZbCu30">
|
||||||
|
We can’t really do that anymore with reality TV. People don’t want to see the fake. So we’re going to be exploring that transition and how it happened under Trump and how the show reacted to it.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8jKr1E">
|
||||||
|
We’re also going to dig into some of the most pivotal moments in <em>90 Day Fiancé</em>, for people who’ve never watched the show and for people who are fans. Characters like <a href="https://www.intouchweekly.com/posts/90-day-fiance-paul-and-karines-relationship-timeline/">Paul and Karine</a>, who really define why the show is so good — Paul, confessing that he was an arsonist and running into the woods. Angela and Michael, and how they have to explore interracial dynamics, how someone can move from Nigeria to the American South and not realize racism still exists in America; Michael literally had no idea until he had to talk to Americans.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zBd8No">
|
||||||
|
We’ll also look at <a href="https://screenrant.com/90-day-fiance-armando-rubio-kenneth-niedermeier-update/">Kenneth and Armando</a>, the show’s first gay male couple. They’re on <a href="https://screenrant.com/90-day-fiance-armando-rubio-kenneth-niedermeier-update/"><em>90 Day Fiancé: The Other Way</em></a>, a spinoff that shows Americans moving to other countries [to be with their partner]. That’s a pivot for the show, saying this isn’t only about American exceptionalism. This is about how people love, what people are afraid of and love, how people change, how people grow.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cCwQNd">
|
||||||
|
We’ll look at the moments on the show that hit on something important, special things that I think changed the landscape and made other reality shows go, “That’s what we need. That’s how you pull people in nowadays.” The glitz and glamour of seeing people on private jets, it’s gone<em>.</em>
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wxCzXW">
|
||||||
|
<em>A full guide to participating in Ray-Harris’s Neither/Nor program </em><a href="https://truefalse.org/program/neither-nor/"><em>is available on the True/False website</em></a><em>. It will take place May 5-9, 2021.</em>
|
||||||
|
</p></li>
|
||||||
|
<li><strong>Bill and Melinda Gates’s divorce could rock the world of charity</strong> -
|
||||||
|
<figure>
|
||||||
|
<img alt="Melinda and Bill Gates." src="https://cdn.vox-cdn.com/thumbor/LxG-eLltQiSmRSxKabgcDZyRDZM=/368x0:2575x1655/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69230224/1219646941.0.jpg"/>
|
||||||
|
<figcaption>
|
||||||
|
Bill and Melinda Gates’ divorce will be closely watched, with possibly huge implications. | Getty Images for Global Citizen
|
||||||
|
</figcaption>
|
||||||
|
</figure>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The billionaire couple is getting a divorce.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oO3x1K">
|
||||||
|
Bill and Melinda Gates, the leaders of the world’s most venerated and powerful philanthropy, said on Monday that they were getting a divorce — an earthquake moment in the nonprofit sector.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LVPJHI">
|
||||||
|
The billionaire couple sets the strategic vision for the $50 billion Bill and Melinda Gates Foundation, which they co-founded and which spends more than $5 billion a year on causes like US education and worldwide disease eradication. Their divorce potentially has enormous implications for their work.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jY7Yir">
|
||||||
|
The Gateses are America’s most famous billionaire philanthropists, with the power and profile to corral foreign governments, lobby for policy change, and <a href="https://www.vox.com/recode/2020/5/13/21254870/bill-gates-coronavirus-giving-pledge-billionaires-gates-foundation">inspire other billionaires</a> to donate their money to charity. During the coronavirus pandemic, Bill Gates in particular has been one of the nation’s leading public health experts, appearing seemingly everywhere in the media and encouraging people to take the virus seriously.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s5aEa4">
|
||||||
|
The couple made the surprise announcement in concurrent posts on their personal Twitter pages. Upon posting the announcement, Melinda Gates added her maiden name, French, to her Twitter profile, suggesting that she may use the full name “Melinda French Gates” going forward.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A7sNVE">
|
||||||
|
In their <a href="https://twitter.com/BillGates/status/1389316412259270657">statement</a>, the Gateses said they would “continue our work together at the foundation.”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kKW9z5">
|
||||||
|
“But we no longer believe we can grow together as a couple in this next phase of our lives.”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1QUWJQ">
|
||||||
|
A Gates Foundation spokesperson said that the philanthropy did not anticipate changes to its work. Both Bill Gates and Melinda Gates will remain co-chairs and trustees of the foundation in their name, a spokesman said.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ihb1sJ">
|
||||||
|
“They will continue to work together to shape and approve foundation strategies, advocate for the foundation’s issues, and set the organization’s overall direction,” a Foundation spokesman said.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tzbgUp">
|
||||||
|
Bill Gates founded Microsoft decades ago but has increasingly turned more and more to his charitable work, resigning from Microsoft’s board last year. Melinda Gates was an early employee at Microsoft herself and has been a hands-on presence for years at their foundation; she also has her own interest in women’s issues that she coordinates through a separate outfit called Pivotal Ventures.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Fm9VTU">
|
||||||
|
Disentangling a fortune of this size — the Gates family, for instance, is <a href="https://www.theguardian.com/commentisfree/2021/apr/05/bill-gates-climate-crisis-farmland#:~:text=Gates'%20achievement%2C%20according%20to%20the,helped%20him%20get%20that%20title.">the country’s largest private owner of farmland</a> — is sure to be complicated. The Gates family has a net worth over $100 billion, and their separation could set records for the largest divorce settlement to date. The largest settlement ever was recorded a few years ago when Jeff Bezos, the world’s wealthiest man, <a href="https://www.vox.com/2019/1/9/18175344/jeff-bezos-divorce-mackenzie-amazon-ceo">finalized a divorce</a> from MacKenzie Scott for about $36 billion.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZiRK1W">
|
||||||
|
While a divorce proceeding is typically a private affair, given how important Bill and Melinda Gates are to the world, this separation could have massive consequences for public life.
|
||||||
|
</p></li>
|
||||||
|
<li><strong>A majority of voters see an urgent need for police reform following the Chauvin verdict</strong> -
|
||||||
|
<figure>
|
||||||
|
<img alt="" src="https://cdn.vox-cdn.com/thumbor/2mHyY_lUDmsLe1TbayGOX4K15Ac=/175x0:2926x2063/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69229651/1228248343.0.jpg"/>
|
||||||
|
<figcaption>
|
||||||
|
A participant holds an End Police Brutality sign at a protest in August 2020. | Erik McGregor/LightRocket/Getty Images
|
||||||
|
</figcaption>
|
||||||
|
</figure>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
A new poll suggests the public is looking to Congress to act on police reform.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LYNG20">
|
||||||
|
A majority of American voters think the need for police reform is even more urgent in the wake of <a href="https://www.vox.com/2021/4/20/22387556/derek-chauvin-verdict-guilty-murder-manslaughter">former police officer Derek Chauvin’s conviction</a> for the murder of George Floyd, according to a <a href="https://www.filesforprogress.org/datasets/2021/4/dfp-vox-chauvin-trial.pdf">new Vox/Data For Progress poll</a>.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7H1JcG">
|
||||||
|
In a survey fielded in the week after his conviction, 55 percent of likely voters said they felt this way, compared to 30 percent who said they believe there was no change in urgency, and 9 percent who said there was less urgency following the trial. The results differed significantly along partisan lines, with 77 percent of Democrats saying police reform was more urgent, and 50 percent of independents and 34 percent of Republicans saying the same.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QbTJkc">
|
||||||
|
<a href="https://www.axios.com/chauvin-verdict-congress-police-reform-1b0472bf-67c8-4b69-9d82-d9e18d62d3e3.html">Previously, Axios has reported</a> that congressional aides felt the verdict helped alleviate pressure on lawmakers to take more action in the near term, because it was the result that many activists and voters supported. “An acquittal or mistrial involving the former police officer would have unleashed violence and days<strong> </strong>more of protests — and added bipartisan pressure to act on criminal and police reform,” <a href="https://www.axios.com/chauvin-verdict-congress-police-reform-1b0472bf-67c8-4b69-9d82-d9e18d62d3e3.html">Axios’s Alayna Treene and Kadia Goba reported</a>. Large-scale demonstrations along those lines might have ramped up the public outcry even more. But as this poll indicates, even absent that, most people still view police reform as a vital issue that lawmakers need to address.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I6ge4r">
|
||||||
|
The poll was conducted as lawmakers in Congress continue negotiations on police reform, and was fielded in two parts, between <a href="https://www.filesforprogress.org/datasets/2021/4/dfp-vox-attitudes-towards-police-reform-toplines.pdf">April 21 and 23</a>, with 1,438 likely voters, and <a href="https://www.filesforprogress.org/datasets/2021/4/dfp-vox-chauvin-trial.pdf">April 23 and 25</a>, with 1,189 likely voters. Both surveys have a 3 percentage point margin of error.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="O0Y348">
|
||||||
|
<a href="https://www.vox.com/2021/5/2/22416155/tim-scott-optimistic-police-reform-senate">As Gabby Birenbaum wrote for Vox</a>, Sen. Tim Scott (R-SC), the lead Republican negotiator on police reform, signaled renewed optimism about a potential deal on the issue this Sunday. The main question now if a deal is reached, is how ambitious — or not — it actually is.
|
||||||
|
</p>
|
||||||
|
<h3 id="eNcgOB">
|
||||||
|
Police reform has floundered in Congress for a year
|
||||||
|
</h3>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kpVq9z">
|
||||||
|
Congress has been here before. Just last year, Senate Democrats had rejected Republicans’ proposal for being too narrow, while GOP leaders argued that House Democrats’ legislation would unnecessarily curb police officers’ legal protections.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Yf0oRn">
|
||||||
|
This year, Scott, along with Sen. Cory Booker (D-NJ) and Rep. Karen Bass (D-CA), are spearheading efforts to find a bipartisan agreement. President Joe Biden has urged Congress to “find a consensus” on police reform by May 25, the anniversary of Floyd’s death, a date Bass has cited as a loose deadline as well.
|
||||||
|
</p>
|
||||||
|
<aside id="jSHsvB">
|
||||||
|
<div>
|
||||||
|
|
||||||
|
</div>
|
||||||
|
</aside>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Romtru">
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||||||
|
Although the existing Democratic and Republican proposals have a lot of differences, Scott has said that he hopes a potential compromise on qualified immunity, a legal shield that makes it tougher to sue police officers for wrongdoing, could lead to a deal. In his proposal, police departments, rather than individual officers, would bear the legal liability in incidents of wrongdoing, an attempt to deter such behavior that wouldn’t put all the risk on the individual.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZRXjzm">
|
||||||
|
“How do we change the culture of policing?” Scott said <a href="https://www.cbsnews.com/news/transcript-sen-tim-scott-on-face-the-nation-may-2-2021/">during a <em>Face the Nation</em> appearance on Sunday</a>. “I think we do that by making the employer responsible for the actions of the employee. We do that with doctors. We do that with lawyers. We do that in most all of our industries. If we do that in law enforcement, the employer will change the culture. As opposed to having one officer change or not change, we’ll have all officers transforming because the departments are taking on more of that burden.”
|
||||||
|
</p>
|
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|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d94gKV">
|
||||||
|
That idea has already prompted some backlash from progressives, <a href="https://www.cnn.com/2021/04/21/politics/policing-reform-talks-congress-latest-negotiations/index.html">including Rep. Jamaal Bowman</a> (D-NY), though Scott is hoping he can eventually get both Democrats and Republicans on board.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="utJ9Ar">
|
||||||
|
<a href="https://www.vox.com/22372342/police-reform-derek-chauvin">As an earlier Vox/DFP poll found in April</a>, a majority of likely voters back police reforms including bans on chokeholds and no-knock warrants, grants for body cameras, and changes to qualified immunity, in some cases by large margins.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P1qrPZ">
|
||||||
|
In <a href="https://www.filesforprogress.org/datasets/2021/4/dfp-vox-attitudes-towards-police-reform-toplines.pdf">the latest survey</a>, the support for curbing qualified immunity has stayed consistent, though far from overwhelming: 51 percent of those polled think people should be able to more easily sue police officers for actions they’ve taken while on duty.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i7D88m">
|
||||||
|
The survey <a href="https://www.filesforprogress.org/datasets/2021/4/dfp-vox-chauvin-trial.pdf">also found</a> that 72 percent of people believed the Chauvin verdict was rightly decided, including 91 percent of Democrats, 72 percent of independents and 51 percent of Republicans. Polling conducted by other outlets following the trial also found strong support for some type of reform effort, though the questions were broader in scope: <a href="https://www.langerresearch.com/wp-content/uploads/1220a1PolicingandRacialJustice.pdf">In an ABC News/Washington Post survey</a>, 60 percent of people said lawmakers should hold the police accountable for the mistreatment of Black people, <a href="https://www.cnn.com/2021/04/27/politics/cnn-poll-chauvin-trial/index.html">and in a CNN survey</a>, 53 percent of people said policing needs major changes.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k5ELmS">
|
||||||
|
Ultimately, <a href="https://theappeal.org/the-lab/polling-memos/voters-support-broad-reforms-to-scope-of-police-work-and-accountability-after-chauvin-verdict/">as</a> these polls revealed, most people are looking to lawmakers to do more, after Congress has stalled on the issue in the past.
|
||||||
|
</p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 surge | India’s FIH Pro League matches in Europe postponed</strong> - The Indian men’s hockey team was scheduled to play against Spain on May 15 and 16, followed by the two-leg tie in Germany on May 23 and 24</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL broadcaster supports BCCI move to indefinitely suspend league</strong> - Star India added that it was “indebted” to its employees, on-air talent, production and broadcast crews for delivering the broadcast to millions of houses in these challenging times</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>After IPL postponement, World T20 could be moved to UAE</strong> - While a final decision will be taken in a month’s time, it is understood that even the Indian cricket board is jittery about holding the 16-team tournament in October-November</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>BCCI suspends IPL 2021 after players test positive for COVID-19</strong> - “We have suspended the IPL for now. The new window will be worked out later on. A statement will follow soon,” IPL chairman Brijesh Patel said</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2021 | CSK-RR match rescheduled after Balaji tests positive for COVID-19</strong> - All CSK playing members have tested negative during their scheduled RT-PCR tests.</p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Number of women MLAs in Assam Assembly declining</strong> - It’s is six this time against a high of 14 in 2011</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>West Bengal post-poll violence: NCW takes suo motu cognisance of attacks on women</strong> - BJP leaders shared videos of the party office in Nandigram being ransacked as well as women supporters of the party being physically assaulted</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ECI asks Bengal govt to give protection, counselling to Nandigram RO</strong> - Mamata has claimed that he did not order a recount of votes as he feared for his life</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watch: DMK takes action against its men who vandalise Amma Unavagam</strong> - A video of Amma Unavagam being vandalised</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mahajot members trade blame for Assam loss</strong> - While the AIUDF held the Congress responsible, the latter pointed to a division of votes by the Raijor Dal-Assam Jatiya Parishad</p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Senior Swiss diplomat in Iran ‘dies in fall from high-rise building’</strong> - Iranian media report that the 51-year-old woman fell from the high-rise building where she lived.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Belgian farmer accidentally moves French border</strong> - The farmer moved a two-century-old border stone into French territory as it was blocking his tractor.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>G7: Foreign ministers discuss global threats at London summit</strong> - Foreign ministers hold their first face-to-face talks for two years, amid tight Covid restrictions.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pandora says laboratory-made diamonds are forever</strong> - The world’s biggest jeweller says it will no longer use mined diamonds in a bid to become more sustainable.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: French lockdown eased to help schools and travel</strong> - Most French secondary pupils return to class and a domestic travel ban is lifted.</p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
|
||||||
|
<ul>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Martian’s Andy Weir is back to form with Project Hail Mary</strong> - Some quick and spoiler-free thoughts on the new book, out today. - <a href="https://arstechnica.com/?p=1761902">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FDA reportedly plans to authorize Pfizer’s COVID vaccine for teens 12-15 in days</strong> - Pfizer previously reported the vaccine was safe and effective in adolescents. - <a href="https://arstechnica.com/?p=1762150">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Epic vs. Apple opening arguments suggest a bitter battle over iOS’ future</strong> - Epic says it’s “suing for change.” Apple says Epic “just doesn’t want to pay.” - <a href="https://arstechnica.com/?p=1762079">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Yet another Google AI leader has defected to Apple</strong> - He will work under John Giannandrea, who also left Google for Apple. - <a href="https://arstechnica.com/?p=1762074">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ajit Pai joins American Enterprise Institute and a firm that invests in ISPs</strong> - Post-FCC Pai will apparently keep pushing deregulation of broadband industry. - <a href="https://arstechnica.com/?p=1762057">link</a></p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
|
||||||
|
<ul>
|
||||||
|
<li><strong>A man decided to join a monastery where you were only allowed to say two words every 10 years</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
[LONG]
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
After 10 years in the monastery the head monk summons’ him and says ‘You’ve been with us for 10 years. What two words would you like to say.’
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The monk replies ‘I’m hungry’, so the head monk organises for an extra ration be given to him each day.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
After 20 years the head monk calls him in again and asks ‘What two words would you like to say?’
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The monk replies with ‘Too cold’, so the head monk organises for him to get another blanket.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
After 30 years the head monk calls him in and says ‘What two words would you like to say’.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The monk replies with ‘Wanna leave’.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The head monk says ‘I’m not surprised. You’ve done nothing but complain since you’ve been here’.
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/AndrewMacSydney"> /u/AndrewMacSydney </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n4dzod/a_man_decided_to_join_a_monastery_where_you_were/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n4dzod/a_man_decided_to_join_a_monastery_where_you_were/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>Now that Bill and Melinda Gates are getting divorced</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
She will be his Xbox
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/ElbowRoni"> /u/ElbowRoni </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n4a9xn/now_that_bill_and_melinda_gates_are_getting/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n4a9xn/now_that_bill_and_melinda_gates_are_getting/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>So there was an assassin who charged $10,000 a bullet</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
A guy comes up to him in the bar one day and says,
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
“Are you the guy who charges $10,000 a bullet?”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
“Yup.”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
“What if you miss?”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
He looks at the man, deadly serious. “I don’t miss…”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
“Okay, well I’ve got $20,000. I just found out my wife is having an affair with my best friend. They’re at the motel together right now.”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
“Let’s go,” the assassin says. So they drive to a store across the street from the motel and climb up on the roof. The assassin takes out his rifle and attaches the scope.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
“They’re in room 21. I want you to shoot her in the head, and I want you to blow his dick off.” The assassin looks through his scope. He keeps staring for several minutes, not taking the shot.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
“Well? What are you waiting for!?” the husband asks. “Hold on a minute,” said the assassin, “I may be able to save you 10 grand.”
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/sidtheslothy23"> /u/sidtheslothy23 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n405js/so_there_was_an_assassin_who_charged_10000_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n405js/so_there_was_an_assassin_who_charged_10000_a/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>Can we ban “yo momma” jokes from this sub? They’re old, stupid and have been done by literally everyone hundreds of times</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Just like yo mamma
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/merio67"> /u/merio67 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n3x0hc/can_we_ban_yo_momma_jokes_from_this_sub_theyre/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n3x0hc/can_we_ban_yo_momma_jokes_from_this_sub_theyre/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>During interviews he seems like such a nice guy, but the actor who plays Wolverine is a real phoney</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
It’s a huge act, man..
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/thiscantberealbutter"> /u/thiscantberealbutter </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n4cwd1/during_interviews_he_seems_like_such_a_nice_guy/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n4cwd1/during_interviews_he_seems_like_such_a_nice_guy/">[comments]</a></span></p></li>
|
||||||
|
</ul>
|
||||||
|
|
||||||
|
|
||||||
|
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|
||||||
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Reference in New Issue