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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Predicting behavioral intentions to prevent or mitigate COVID-19: A cross-cultural meta-analysis of attitudes, norms and perceived behavioral control effects</strong> -
<div>
We examined the effectiveness of attitudes, subjective norms and perceived behavioral control (PBC) of the Theory of Planned Behavior (TPB) on COVID-19 relevant behavioral intentions and behaviors. We conducted a meta-analysis of 335 effect sizes from 83 samples across 31 countries (N = 68,592). We found strongest effects for perceived behavioral control, but contrary to previous research also moderately strong effects of subjective norms. Focusing on systematic context effects: a) norm-behavior associations at individual level were strengthened if population norms were stronger, b) collectivism strengthened norm effects in line with cultural theories, but also attitude and PBC associations, suggesting that COVID-relevant behaviors show collective action properties, c) in line with cultural theory, tightness-looseness strengthened normative effects on behaviors, and d) contrary to post-modernization theory, national wealth weakened attitude and PBC associations. These analyses provide new theoretical and practical insights into behavioral dynamics during an acute public health crisis.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/ek69g/" target="_blank">Predicting behavioral intentions to prevent or mitigate COVID-19: A cross-cultural meta-analysis of attitudes, norms and perceived behavioral control effects</a>
</div></li>
<li><strong>Covid-19: acquired acute porphyria hypothesis</strong> -
<div>
Pandemic Covid-19 pneumonia, of SARS-CoV-2 aetiology, is of global importance to health systems, national economies and individual civil liberties. Multiple therapeutic and prophylactic agents are currently undergoing clinical trial and, while progress towards a curative agent is promising, the principal limiting factor in public health emergency is time. A pre-existing licensed therapeutic would offer reprieve to international citizens currently enduring the adverse consequences of lockdown policies. This brief communication serves as an update on the initial version of the acquired acute porphyria hypothesis and advocates for direct testing of the hypothesis.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/fxz3p/" target="_blank">Covid-19: acquired acute porphyria hypothesis</a>
</div></li>
<li><strong>The 501Y.V2 SARS-CoV-2 variant has an intermediate viral load between the 501Y.V1 and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The 501Y.V2 and the 501Y.V1 SARS-CoV-2 variants emerged and spread rapidly into the world. We analysed the viral load of 643 nasopharyngeal samples of COVID-19 patients at diagnosis and found that the 501Y.V1 and the 501Y.V2 variants presented a viral load three to ten times and two times higher than the historical variants, respectively..
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.21.21253498v2" target="_blank">The 501Y.V2 SARS-CoV-2 variant has an intermediate viral load between the 501Y.V1 and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients</a>
</div></li>
<li><strong>Predicting Emerging Themes in Rapidly Expanding COVID-19 Literature with Dynamic Word Embedding Networks and Machine Learning</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Evidence from peer-reviewed literature is the cornerstone for designing responses to global threats such as COVID-19. The collection of knowledge and interpretation in publications needs to be distilled into evidence by leveraging natural language in ways beyond standard meta-analysis. Several studies have focused on mining evidence from text using natural language processing, and have focused on a handful of diseases. Here we show that new knowledge can be captured, tracked and predicted using the evolution of unsupervised word embeddings and machine learning. Our approach to decipher the flow of latent knowledge in time-varying networks of word-vectors captured thromboembolic complications as an emerging theme in more than 77,000 peer-reviewed publications and more than 11,000 WHO vetted preprints on COVID-19. Furthermore, machine learning based prediction of emerging links in the networks reveals autoimmune diseases, multisystem inflammatory syndrome and neurological complications as a dominant research theme in COVID-19 publications starting March 2021.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.14.21249855v2" target="_blank">Predicting Emerging Themes in Rapidly Expanding COVID-19 Literature with Dynamic Word Embedding Networks and Machine Learning</a>
</div></li>
<li><strong>The impact of pandemic-related worry on cognitive functioning and risk-taking</strong> -
<div>
Here, we sought to quantify the effects of experienced fear and worry, engendered by the COVID-19 pandemic, on both cognitive abilities—speed of information processing, task-set shifting, and proactive control—as well as economic risk-taking. Leveraging a repeated-measures cross-sectional design, we examined the performance of 1517 participants, collected during the early phase of the pandemic in the US (April – June 2020), finding that self-reported pandemic-related worry predicted deficits in information processing speed and maintenance of goal-related context information. Cognitive performance was also impaired relative to pre-pandemic ‘baseline’ samples. In a classic economic risk-taking task, we also observed that more worried individuals’ choices were more sensitive to outcome probabilities of risky actions. Overall, these results elucidate the cognitive consequences of pandemic worry, which may play an important role in individuals’ understanding of—and adherence to—public health directives.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/wxmks/" target="_blank">The impact of pandemic-related worry on cognitive functioning and risk-taking</a>
</div></li>
<li><strong>A semi qualitative study on the perception of the general public to the presence of the first COVID-19 patient in the locality</strong> -
<div>
Introduction: Infectious diseases have had a significant role in shaping human history by engraving a subconscious sense of ‘fear of infection’. The three sequential stages of the rational response to fear- fear, denial, and frustration, have been reported as predominant among quarantined individuals during any outbreak. To our knowledge, this was one of the first studies to assess the impact of the first case of COVID-19 among the neighbouring dwellers. Methods: A semi-qualitative study was conducted through telephonic interviews. Detailed descriptions of the experiences of the inhabitants after coming to know about the first incidence of a patient of COVID-19 in the locality were obtained. Participants were recruited through purposive and snowball sampling. Semi-structured in-depth telephonic interviews were done at a time convenient for participants between April 9 to 11, 2020. Results: Source of information for all the participants was from a neighbour and the participants came to know about the news on 7th of April 2020. All the participants were aware of the correct attitudes and practices of the general public to be followed during the pandemic including hand hygiene, use of face masks, social distancing and adhering to the government lockdown rules. Mixed reactions of panic, fear and confusion were obtained. Most participants were concerned about children and elderly at home, financial constraints due to the blockage of the locality from adjoining areas, everyday hassles that they were about to experience, etc. Despite most participants having minimal fear of contracting the illness themselves, fear of a family member acquiring the same seemed to be significantly higher on hearing the news. Conclusion The study adds to the existing literature that fear and anxiety during a pandemic are mostly due to the uncertainty related to the disease spread and misinformation. There is a need for phased and well informed lockdown implementation and better knowledge propagation among the general public in order to mitigate unwanted fear and panic among the general public.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/wc5y6/" target="_blank">A semi qualitative study on the perception of the general public to the presence of the first COVID-19 patient in the locality</a>
</div></li>
<li><strong>COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal and child health following Cochrane methods and PRISMA statement for reporting (PROSPERO-CRD42020208783). Methods We searched literature databases and COVID-19 research websites from January to October 2020. We selected relevant SRs reporting adequate search strategy, data synthesis, risk of bias assessment, and/or individual description of included studies describing COVID-19 and pregnancy outcomes. Pair of reviewers independently selected studies through COVIDENCE web-software, performed the data extraction, and assessed its quality through the AMSTAR-2 tool. Discrepancies were resolved by consensus. Each SR9s results were synthesized and for the most recent, relevant, comprehensive, and with the highest quality, by predefined criteria, we presented GRADE evidence tables. Results We included 66 SRs of observational studies out of 608 references retrieved and most (61/66) had “critically low” overall quality. We found a relatively low degree of primary study overlap across SRs. The most frequent COVID-19 clinical findings during pregnancy were fever (28-100%), mild respiratory symptoms (20-79%), raised C-reactive protein (28-96%), lymphopenia (34-80%), and pneumonia signs in diagnostic imaging (7-99%). The most frequent maternal outcomes were C-section (23-96%) and preterm delivery (14-64%). Most of their babies were asymptomatic (16-93%) or presented fever (0-50%), low birth weight (5-43%) or preterm delivery (2-69%). The odds ratio (OR) of receiving invasive ventilation for COVID-19 versus non-COVID-19 pregnant women was 1.88 (95% Confidence Interval [CI] 1.36-2.60) and the OR that their babies were admitted to neonatal intensive care unit was 3.13 (95%CI 2.05-4.78). The risk of congenital transmission or via breast milk was estimated to be low, but close contacts may carry risks. Conclusion This comprehensive overview supports that pregnant women with COVID-19 may be at increased risk of adverse pregnancy and birth outcomes and low risk of congenital transmission.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256327v1" target="_blank">COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes</a>
</div></li>
<li><strong>Modelling digital and manual contact tracing for COVID-19. Are low uptakes and missed contacts deal-breakers?</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Comprehensive testing schemes, followed by adequate contact tracing and isolation, represent the best public health interventions we can employ to reduce the impact of an ongoing epidemic when no or limited vaccines are available and the implications of a full lockdown are to be avoided. However, the process of tracing can prove feckless for highly-contagious viruses such as SARS-Cov-2. The interview-based approaches often miss contacts and involve significant delays, while digital solutions can suffer from insufficient adoption rates or inadequate usage patterns. Here we present a novel way of modelling different contact tracing strategies using a generalized multi-site mean-field model, which can naturally assess the impact of both manual and digital approaches. Our methodology can readily be applied to any compartmental formulation, thus enabling the study of several complex pathogens. We use this technique to simulate a new epidemiological model, SEIR-T, and show that, given the right conditions, tracing in a COVID-19 epidemic can be effective even when digital uptakes are sub-optimal or interviewers miss a fair proportion of the contacts.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256307v1" target="_blank">Modelling digital and manual contact tracing for COVID-19. Are low uptakes and missed contacts deal-breakers?</a>
</div></li>
<li><strong>Hypercoagulation detected by Rotational Thromboelastometry predicts mortality in COVID-19: A risk model based on a prospective observational study.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
ABSTRACT Background: Severe disease due to COVID-19 has been shown to be associated with hypercoagulation. Early identification of prothrombotic patients may help guiding anticoagulant treatment and improve survival. The aim of this study was to assess Rotational Thromboelastmetry (ROTEM) as a marker of coagulopathy in hospitalized COVID-19 patients. Methods: This was a prospective, observational study. Patients hospitalized due to a COVID-19 infection were eligible for inclusion. Conventional coagulation tests and ROTEM were taken after hospital admission, and patients were followed for 30 days. Patient characteristics and outcome variables were collected, and a prediction model including variables age, respiratory frequency and ROTEM EXTEM-MCF, was developed using logistic regression to evaluate the probability of death. Results: Out of the 141 patients included, 18 (13%) died within 30 days. D-dimer (p=0.01) and Activated Partial Thromboplastin Time (APTT) (p=0.002) were increased, and ROTEM EXTEM-/INTEM-CT (p&lt;0.001) were prolonged in non-survivors. In the final prediction model, the risk of death within 30 days for a patient hospitalized due to COVID-19 was increased with increased age, respiratory frequency and EXTEM-MCF. Longitudinal ROTEM data in the severely ill subpopulation showed enhanced hypercoagulation. In our in vitro analysis, no heparin effect on EXTEM-CT was observed, supporting a SARS-CoV-2 effect on initiation of coagulation. Conclusions: Here we show that hypercoagulation measured with ROTEM predicts 30-day mortality in COVID-19. Longitudinal ROTEM data strengthen the hypothesis of hypercoagulation as a driver of severe disease in COVID-19. Thus, ROTEM may be a useful tool to assess disease severity in COVID-19, and could potentially guide anticoagulation therapy.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256241v1" target="_blank">Hypercoagulation detected by Rotational Thromboelastometry predicts mortality in COVID-19: A risk model based on a prospective observational study.</a>
</div></li>
<li><strong>A 6-mRNA host response whole-blood classifier trained using patients with non-COVID-19 viral infections accurately predicts severity of COVID-19</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background Determining the severity of COVID-19 remains an unmet medical need. Our objective was to develop a blood-based host-gene-expression classifier for the severity of viral infections and validate it in independent data, including COVID-19. Methods We developed the classifier for the severity of viral infections and validated it in multiple viral infection settings including COVID-19. We used training data (N=705) from 21 retrospective transcriptomic clinical studies of influenza and other viral illnesses looking at a preselected panel of host immune response messenger RNAs. Results We selected 6 host RNAs and trained logistic regression classifier with a cross-validation area under curve of 0.90 for predicting 30-day mortality in viral illnesses. Next, in 1,417 samples across 21 independent retrospective cohorts the locked 6-RNA classifier had an area under curve of 0.91 for discriminating patients with severe vs. non-severe infection. Next, in independent cohorts of prospectively (N=97) and retrospectively (N=100) enrolled patients with confirmed COVID-19, the classifier had an area under curve of 0.89 and 0.87, respectively, for identifying patients with severe respiratory failure or 30-day mortality. Finally, we developed a loop-mediated isothermal gene expression assay for the 6-messenger-RNA panel to facilitate implementation as a rapid assay. Conclusions With further study, the classifier could assist in the risk assessment of COVID-19 and other acute viral infections patients to determine severity and level of care, thereby improving patient management and reducing healthcare burden.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.07.20230235v2" target="_blank">A 6-mRNA host response whole-blood classifier trained using patients with non-COVID-19 viral infections accurately predicts severity of COVID-19</a>
</div></li>
<li><strong>Is WHO International Standard for Anti-SARS-CoV-2 Immunoglobulin Clinically Useful?</strong> -
<div>
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Background: The introduction of vaccination against SARS-CoV-2 infection needs precise instruments for quality control of vaccination procedure, detection of poor immunological response and estimation of the achieved protection against the disease but also against infection and being infective. Objective: To compare new automated SARS-CoV 2 Ig assay performance characteristics from the automated Elecsys SARS CoV 2 S (Roche) with the new LIAISON SARS-CoV-2 TrimericS IgG (DiaSorin) assay and their compatibility with WHO International Standard for anti-SARS-CoV-2 immunoglobulin. In the context of the mass vaccination programs, we undertook the investigation of clinical utility of the two new automated assays by analyzing results in samples collected at specified time points relative to the vaccination time. Design: Prospective assay evaluation. Patients: Medical staff undergoing vaccination with BioNTech/Pfizer Comirnaty vaccine between January and March 2021 (n = 79) and referred for serum antiSARS-CoV 2 Ig testing prior to vaccination, 21 days after the first dose, and 8, 14 and 30 days after the second dose. Main Outcome Measure(s): Serum antibody levels measured with Roche and DiaSorin assays. Results: Intra-assay imprecision was low with DiaSorin at 3.46%; and Roche at 2.5%. The Passing-Bablok regression equation for all tested samples was y (DiaSorin) = 184.61 + (1.03 x Roche) and the correlation between the assays (r=0.587; p &lt; 0.0001). Conclusions: The novel automated assays exhibit strong concordance in calibration, with assay-specific interpretation required for routine clinical use. These results highlight the need for further work on the international standard of measurement of SARS-CoV 2 Ig especially in era of vaccination. The serological assays can be useful to detect IgG/IgM antibodies, to assess the degree of immunization, to trace the contacts, and to support the decision to readmit people to work or vaccinate them again. However, the values generated by both assays can be markedly different, and assay-specific and personalized interpretation is required.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256246v1" target="_blank">Is WHO International Standard for Anti-SARS-CoV-2 Immunoglobulin Clinically Useful?</a>
</div></li>
<li><strong>Rapid implementation of cross-sectional study: Post-acute sequelae of SARS-CoV-2 (PASC) in a racially and ethnically diverse sample in Illinois</strong> -
<div>
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ABSTRACT Little is known about the pattern and course of recovery following acute COVID-19. Increasing numbers of reports describe persistent illness following infection with SARS-COV-2, also known as Post-Acute Sequelae of SARS-CoV-2 (PASC). This report describes the methods and results of a multi-pronged strategy to rapidly identify and enroll, over a one week period in April 2021, a racially and ethnically diverse sample of individuals and to characterize PASC among a this diverse sample. Participants were recruited through community outreach, clinical registries, and research registries across four cities in Illinois to complete an online survey. We examined presence of symptoms among 246 individuals who were at least three months past testing positive for SARS-CoV-2. Respondents were 70% female; 48% Hispanic/Latinx; 18% Black, and 28% White. Most had mild illness (78% were not hospitalized), and 26% reported they had not yet returned to their usual health within 3 months of their diagnosis. The most prevalent symptoms persisting 3-months following COVID-19 diagnosis included fatigue (20%), difficulty thinking (19%), problems with taste or smell (15%), and muscle or body aches (15%). In a multivariable logistic regression model, older age (40-59 vs. 18-39 years: adjusted odds ratio [aOR] = 0.46 [95% confidence interval, 0.24 to 0.90]) and having been hospitalized with COVID-19 (vs. not hospitalized: aOR = 0.28 [0.12 to 0.64]) were independently associated with a lower likelihood of recovery within 3 months. Compromised health continued well beyond the acute phase of COVID-19 in our ethnically diverse sample, especially among older individuals and those who were hospitalized. The partnerships with community- and faith-based organizations developed for the current study offer the potential to broadly disseminate study findings and to further understand and mitigate underlying determinants of risk, severity, and duration of PASC.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256304v1" target="_blank">Rapid implementation of cross-sectional study: Post-acute sequelae of SARS-CoV-2 (PASC) in a racially and ethnically diverse sample in Illinois</a>
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<li><strong>The comparison of vaccine hesitancy of COVID-19 vaccination in China and the United States</strong> -
<div>
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Background: To investigate the differences in vaccine hesitancy and preference of the currently available COVID-19 vaccines between two countries, viz. China and the United States (US). Method: A cross-national survey was conducted in both China and the US, and discrete choice experiments as well as Likert scales were utilized to assess vaccine preference and the underlying factors contributing to the vaccination acceptance. A propensity score matching (PSM) was performed to enable a direct comparison between the two countries. Results: A total of 9,077 (5,375 and 3,702, respectively, from China and the US) respondents have completed the survey. After propensity score matching, over 82.0% respondents from China positively accept the COVID-19 vaccination, while 72.2% respondents form the US positively accept it. Specifically, only 31.9% of Chinese respondents were recommended by a doctor to have COVID-19 vaccination, while more than half of the US respondents were recommended by a doctor (50.2%), local health board (59.4%), or friends and families (64.8%). The discrete choice experiments revealed that respondents from the US attached the greatest importance to the efficacy of COVID-19 vaccines (44.41%), followed by the cost of vaccination (29.57%), whereas those from China held a different viewpoint that the cost of vaccination covers the largest proportion in their trade-off (30.66%), and efficacy ranked as the second most important attribute (26.34%). Also, respondents from China tend to concern much more about the adverse effect of vaccination (19.68% vs 6.12%) and have lower perceived severity of being infected with COVID-19. Conclusion: While the overall acceptance and hesitancy of COVID-19 vaccination in both countries are high, underpinned distinctions between countries are observed. Owing to the differences in COVID-19 incidence rates, cultural backgrounds, and the availability of specific COVID-19 vaccines in two countries, the vaccine rollout strategies should be nation-dependent.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256317v1" target="_blank">The comparison of vaccine hesitancy of COVID-19 vaccination in China and the United States</a>
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<li><strong>Transition in Learning Approach for Undergraduate Medical Students of Bangladesh in Covid 19 Pandemic: A Situation Analysis</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background and Objectives: The outbreak of Covid 19 pandemic has fundamentally transformed the landscape of medical education system upside down worldwide. And this unanticipated transition of medical education without any pre build infrastructure has made this altered prospect more challenging in Bangladesh. Though many countries across the world utilize web based learning along with traditional approach, but medical students of Bangladesh are mostly unfamiliar and unaccustomed with this newly imposed online learning avenue. Therefore, this study has evaluated the familiarity, usage, attitude of students towards online class and figured out the barriers witnessed by students in web based learning in Bangladesh prospect. Methods: This cross sectional, questionnaire based study was conducted in medical colleges across Bangladesh. A questionnaire linked to google form were distributed to undergraduate medical students all over Bangladesh through different social platforms. Students who showed interest, filled up the questionnaire with consent and submitted voluntarily. Those answered questionnaires were automatically stored in Google drive in a specific email ID. After completion of data collection, all data were transferred in a spread sheet and statistical analysis was done. Results: A total of 1709 students participated in this study willingly from around Bangladesh. Among the respondents 45.1% were satisfied with online class. Though most of the students (45.8%) think online class in medical education is not effective like traditional lectures but many of them (47.4%) agrees to the point that online class should have complementary role in medical education. One of the strong attitude of medical students regarding web based learning revealed in this study that, most of them undoubtedly in unison (49.5% disagree, 30.3% strongly disagree) with that web based learning can never replace traditional lecture class in medical education. 77.2% students responded that web based learning is interactive. 54.9% students pointed out that they experienced interrupted internet connections with low internet speed during class time which is a barrier to WBL. 83.2% of the respondents complained about facing audio visual problem during online class which is attributed to the poor network connectivity. Most students in Bangladesh (74.8%) found online classes costly and 53.8% of the students needed technical supports for continued online class. Conclusion: This study finding can suggest a potential reform for medical education system of Bangladesh addressing the obstacles and expectations of students which can execute a fruitful web based learning in Bangladesh.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256358v1" target="_blank">Transition in Learning Approach for Undergraduate Medical Students of Bangladesh in Covid 19 Pandemic: A Situation Analysis</a>
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<li><strong>Quantifying COVID-19 vaccination hesitancy during early vaccination rollout in Canada</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Understanding vaccination hesitancy during early vaccination rollout in Canada can help the government9s vaccination efforts in education and outreach, which may help eventually achieving herd immunity. This study uses an online survey to assess vaccination hesitancy in population subgroups in Canada. Method: Panel members from the nationally representative Angus Reid Forum were randomly invited to complete an online survey on their experiencing with COVID-19 symptoms and testing, as well as intention to vaccination against COVID-19. Respondents were asked “when a vaccine against the coronavirus becomes available to you, will you get vaccinated or not?” Vaccination hesitancy was defined as choosing “No - I will not get a coronavirus vaccination” as a response. Results: 14,621 panel members (46% male and 53% female) completed the survey. Although the respondents overrepresent age 60+ and higher levels of education, other demographics, the prevalences of smoking, obesity, diabetes and hypertension were comparable to the Canadian national census and health surveys. COVID-19 vaccination hesitancy is relatively low overall (9%). Being a resident of Alberta (predicted probability = 15%), aged 40-59 (OR = 0.87, 0.78-0.97, predicted probability = 12%), identifying as a visible minority (OR = 0.56, 0.37-0.84, predicted probability = 15%), having some college level education or lower (predicted probability = 14%), or living in households of at least 5 are related to greater vaccination hesitancy (OR = 0.82, 0.76-0.88, predicted probability = 13%). Conclusion: Our study enhances the understanding of COVID-19 vaccination hesitancy and identifies key population groups with higher vaccination hesitancy. As the Canadian COVID-19 vaccination effort continues, policymakers may focus outreach, education, and other efforts on these groups, which also represent groups with higher risks for contracting and dying from COVID-19. Furthermore, Canada would need to vaccinate virtually the entire population to reach herd immunity due to its relatively low infection level, and a high vaccination hesitancy would be a major hurdle to achieving that.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.29.21256333v1" target="_blank">Quantifying COVID-19 vaccination hesitancy during early vaccination rollout in Canada</a>
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</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Oestrogen Treatment for COVID-19 Symptoms</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Transdermal estradiol gel<br/><b>Sponsors</b>:   Hamad Medical Corporation;   Laboratoires Besins International<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virgin Coconut Oil as Adjunctive Therapy for Hospitalized COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Virgin Coconut Oil<br/><b>Sponsors</b>:   University of the Philippines;   Philippine Coconut Authority;   Philippine Council for Health Research &amp; Development<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impact of GSE and Xylitol (Xlear) on COVID-19 Symptoms and Time to PCR Negativisation in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: GSE and Xylitol<br/><b>Sponsor</b>:   Larkin Community Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19</strong> - <b>Conditions</b>:   Covid19;   COVID-19 Prevention<br/><b>Interventions</b>:   Drug: Hydroxychloroquine (HCQ);   Other: Standard care;   Other: Placebo<br/><b>Sponsor</b>:   Postgraduate Institute of Medical Education and Research<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate a Single Dose of LTX-109 in Subjects With COVID-19 (Coronavirus Disease 2019) Infection.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: LTX-109 gel, 3%;   Drug: Placebo gel<br/><b>Sponsors</b>:   Pharma Holdings AS;   Clinical Trial Consultants AB<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Detection of Covid-19 in Nasopharyngeal Swabs by Using Multi-Spectral Spectrophotometry</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: AP-23<br/><b>Sponsor</b>:   Fable Biyoteknoloji San ve Tic A.S<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Clinical Trial to Evaluate the Recombinant SARS-CoV-2 Vaccine (CHO Cell) for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: low-dose Recombinant SARS-CoV-2 Vaccine (CHO cell);   Biological: high-dose Recombinant SARS-CoV-2 Vaccine (CHO cell);   Biological: placebo<br/><b>Sponsors</b>:   National Vaccine and Serum Institute, China;   Lanzhou Institute of Biological Products Co., Ltd;   Beijing Zhong Sheng Heng Yi Pharmaceutical Technology Co., Ltd.;   Zhengzhou University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Demi-dose of Two Covid-19 mRNA Vaccines in Healthy Population</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: immunogenicity after first and second dose<br/><b>Sponsors</b>:   Sciensano;   Mensura EDPB;   Institute of Tropical Medicine, Belgium;   Erasme University Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Niclosamide in Patients With COVID-19 With Gastrointestinal Infection</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Niclosamide;   Drug: Placebo<br/><b>Sponsor</b>:   AzurRx BioPharma, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Immunobridging and Immunization Schedules Study of COVID-19 Vaccine (Vero Cell), Inactivated</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: 3-doses schedule 1 of COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: 3-doses schedule 2 of COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: 3-doses schedule 3 of COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: 2 doses of vaccine<br/><b>Sponsors</b>:   China National Biotec Group Company Limited;   Beijing Institute of Biological Products Co Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Selenium (as Selenious Acid);   Other: Placebo<br/><b>Sponsors</b>:   CHRISTUS Health;   Pharco Pharmaceuticals<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Estradiol and Progesterone in Hospitalized COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Placebo injection and placebo pill;   Drug: Estradiol Cypionate 5 MG/ML;   Drug: Progesterone 200 MG Oral Capsule<br/><b>Sponsor</b>:   Tulane University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Close Contact Self-Testing Study</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Behavioral: COVID-19 self-test;   Behavioral: COVID-19 test referral<br/><b>Sponsors</b>:   University of Pennsylvania;   Public Health Management Corporation<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>#SafeHandsSafeHearts: An eHealth Intervention for COVID-19 Prevention and Support</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Behavioral: eHealth for Covid-19 prevention and support<br/><b>Sponsor</b>:   University of Toronto<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Vaccination Take-Up</strong> - <b>Conditions</b>:   Covid19;   Vaccination<br/><b>Interventions</b>:   Behavioral: Financial incentives;   Behavioral: Convenient scheduling link;   Behavioral: Race concordant;   Behavioral: Gender concordant<br/><b>Sponsors</b>:   University of Southern California;   Contra Costa Health Services;   J-PAL North America, State and Local Innovation Initiative;   National Bureau of Economic Research Roybal Center;   National Institute on Aging (NIA)<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Modelling studies reveal the importance of the C-terminal inter motif loop of NSP1 as a promising target site for drug discovery and screening of potential phytochemicals to combat SARS-CoV-2</strong> - COVID-19 pandemic causative SARS-CoV-2 coronavirus is still rapid in progression and transmission even after a year. Understanding the viral transmission and impeding the replication process within human cells are considered as the vital point to control and overcome COVID-19 infection. Non-structural Protein 1, one among the proteins initially produced upon viral entry into human cells, instantly binds with the human ribosome and inhibit the host translation process by preventing the mRNA…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bile acids LCA and CDCA inhibited porcine deltacoronavirus replication in vitro</strong> - Porcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus that causes gastroenteritis in pigs and no vaccines or antiviral drugs are available. Bile acids are active factors in intestines and influence the replication of enteric viruses. Currently, the role of bile acids on PDCoV replication is unknown. In this study, we tested the effects of different types of bile acids on the replication of PDCoV in cell culture. We found that physiological concentrations of bile acids…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reconstitution and functional characterization of SARS-CoV-2 proofreading complex</strong> - The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) has led to a world-wild pandemic. The replication of SARS-CoV-2 RNA genome involves the core replication-transcription complex (RTC, nsp12-nsp7-nsp8) and the proofreading complex (nsp14-nsp10) that can correct mismatched base pairs during replication. Structures and functions of SARS-CoV-2 RTC have been actively studied, yet little is known about SARS-CoV-2 nsp14-nsp10. Here, we purified, reconstituted, and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Endothelin Antagonism and Sodium Glucose Co-transporter 2 Inhibition A Potential Combination Therapeutic Strategy for COVID-19</strong> - The novel coronavirus 2019 (COVID-19) infection caused by SARS-CoV-2 is a global pandemic that requires a multi-faceted approach to tackle this unprecedent health crisis. Therapeutics to treat COVID-19 are an integral part of any such management strategy and there is a substantial unmet need for treatments for individuals most at risk of severe disease. This perspective review provides rationale of a combined therapeutic regimen of selective endothelin-A (ET-A) receptor antagonism and sodium…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus</strong> - Feline infectious peritonitis (FIP) is a fatal systemic disease of felids caused by a Coronavirus (CoV) (FIPV). In spite of its clinical relevance and impact on feline health, currently the therapeutic possibilities for treatment of FIP in cats are limited. The emergence of the pandemic Severe Respiratory Syndrome (SARS) coronavirus (CoV) type 2 (SARS-CoV-2), etiological agent of the 2019 Coronavirus Disease (COVID-19), able to infect a broad spectrum of animal species including cats, triggered…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The systemic pro-inflammatory response: targeting the dangerous liaison between COVID-19 and cancer</strong> - Inflammation is an established driver of severe SARS-CoV-2 infection and a mechanism linked to the increased susceptibility to fatal COVID-19 demonstrated by patients with cancer. As patients with cancer exhibit a higher level of inflammation compared with the general patient population, patients with cancer and COVID-19 may uniquely benefit from strategies targeted at overcoming the unrestrained pro-inflammatory response. Targeted and non-targeted anti-inflammatory therapies may prevent…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro</strong> - Since the beginning of December 2019, a novel Coronavirus severe respiratory disease, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which also been termed 2019-new CoV (2019-nCoV), has continued to spread worldwide. As of August 27, 2020, a total of 24,232,429 people have been infected and 826,518 people have died. In our study, we found that astemizole can antagonize ACE2 and inhibit the entry of SARS-COV-2 spike pseudovirus into ACE2-expressed HEK293T cells (ACE2hi…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule</strong> - LianhuaQingwen capsule, prepared from an herbal combination, is officially recommended as treatment for COVID-19 in China. Of the serial pharmacokinetic investigations we designed to facilitate identifying LianhuaQingwen compounds that are likely to be therapeutically important, the current investigation focused on the component Glycyrrhiza uralensis roots (Gancao). Besides its function in COVID-19 treatment, Gancao is able to induce pseudoaldosteronism by inhibiting renal 11β-HSD2. Systemic and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Overlap of immunotherapy-related pneumonitis and COVID-19 pneumonia: diagnostic and vaccine considerations</strong> - The clinically indistinguishable overlap between pneumonitis caused due to immune checkpoint inhibition (ICI) and pneumonia associated with COVID-19 has posed considerable challenges for patients with cancer and oncologists alike. The cancer community continues to face the challenges that lay at the complex immunological intersection of immune-based cancer therapy and immune dysregulation that results from COVID-19. Is there compounded immune dysregulation that could lead to poor outcomes? Could…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Functional landscape of SARS-CoV-2 cellular restriction</strong> - A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular effectors that govern IFN control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function analysis that evaluated the impact of human IFN-stimulated genes (ISGs) on viral replication. A limited subset of ISGs were found to control viral infection, including…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro</strong> - We recently discovered a superantigen-like motif sequentially and structurally similar to a staphylococcal enterotoxin B (SEB) segment, near the S1/S2 cleavage site of the SARS-CoV-2 spike protein, which might explain the multisystem inflammatory syndrome (MIS-C) observed in children and the cytokine storm in severe COVID-19 patients. We show here that an anti-SEB monoclonal antibody (mAb), 6D3, can bind this viral motif at its polybasic (PRRA) insert to inhibit infection in live virus assays….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment</strong> - COVID-19 has been diffusely pandemic around the world, characterized by massive morbidity and mortality. One of the remarkable threats associated with mortality may be the uncontrolled inflammatory processes, which were induced by SARS-CoV-2 in infected patients. As there are no specific drugs, exploiting safe and effective treatment strategies is an instant requirement to dwindle viral damage and relieve extreme inflammation simultaneously. Here, highly biocompatible glycyrrhizic acid (GA)…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human beta-Coronavirus Infection</strong> - Hexameric structure formation through packing of three C-terminal helices and an N-terminal trimeric coiled-coil core has been proposed as a general mechanism of class I enveloped virus entry. In this process, the C-terminal helical repeat (HR2) region of viral membrane fusion proteins becomes transiently exposed and accessible to N-terminal helical repeat (HR1) trimer-based fusion inhibitors. Herein, we describe a mimetic of the HIV-1 gp41 HR1 trimer, N3G, as a promising therapeutic against…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Screening for inhibitory effects of crude drugs on furin-like enzymatic activities</strong> - The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a cleavage motif R-X-X-R for furin-like enzymes at the boundary of the S1/S2 subunits. The cleavage of the site by cellular proteases is essential for S protein activation and virus entry. We screened the inhibitory effects of crude drugs on in vitro furin-like enzymatic activities using a fluorogenic substrate with whole-cell lysates. Of the 124 crude drugs listed in the Japanese Pharmacopeia, aqueous…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors</strong> - The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main protease M^(pro) to cleave the virus-encoded polyproteins. Despite a wealth of experimental information already available, there is wide disagreement about the M^(pro) monomer-dimer equilibrium dissociation constant. Since the functional unit of M^(pro) is a homodimer, the detailed knowledge of the thermodynamics of this equilibrium is a key piece of information for…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A COMPREHENSIVE DISINFECTION SYSTEM DURING PANDEMIC FOR PERSONAL ITEMS AND PROTECTIVE EQUIPMENT (PPE) TO SAFEGUARD PEOPLE</strong> - The current Covid-19 pandemic has led to an enormous demand for gadgets / objects for personal protection. To prevent the spread of virus, it is important to disinfect commonly touched objects. One of the ways suggested is to use a personal UV-C disinfecting box that is “efficient and effective in deactivating the COVID-19 virus. The present model has implemented the use of a UV transparent material (fused silica quartz glass tubes) as the medium of support for the objects to be disinfected to increase the effectiveness of disinfection without compromising the load bearing capacity. Aluminum foil, a UV reflecting material, was used as the inner lining of the box for effective utilization of the UVC light emitted by the UVC lamps. Care has been taken to prevent leakage of UVC radiation out of the system. COVID-19 virus can be inactivated in 5 minutes by UVC irradiation in this disinfection box - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN322882412">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USE OF IMINOSUGAR COMPOUND IN PREPARATION OF ANTI-SARS-COV-2 VIRUS DRUG</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU322897928">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU321590214">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD FOR QUANTIFICATION OF PIRFENIDONE, A COVID-19 ANTI-FIBROTIC AGENT, BY SENSITIVE ANALYTICAL TECHNIQUES</strong> - This invention relates to the development of specific methods for quantification of pirfenidone, an anti-fibrotic drug which is used to treat Covid-19 for curing lung infections. Ultra-Violet spectroscopy detection and quantification conducted using HPLC grade water as solvent. Linearity constructed for the concentration range of 3-15µL for UV spectroscopy, 2-10 µg/ml for HPLC using methanol as diluent and 5-25µg/ml using methanol as diluent for HPTLC. The chromatographic system comprised of HPLC system equipped with quaternary gradient pump and Shim-Pack GIST C18 (250X 4.6 mm, 5µm) column with PDA detector monitored at 310nm. HPTLC performed on silica gel 60 F254 plates using mobile phase in the ratio of toluene and methanol 8:2 v/v. Analytical method validation done according to ICH Q2 (R1) guidelines. System suitability, intraday precision and inter day precision calculations performed and reported which found to be within limits (%RSD&lt;2%). Recovery studies performed and amount recovered is found between 98.20-102.20%. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN322881663">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>5-(4-TERT-BUTOXY PHENYL)-3-(4N-OCTYLOXYPHENYL)-4,5-DIHYDROISOXAZOLE MOLECULE (C-I): A PROMISING DRUG FOR SARS-COV-2 (TARGET I) AND BLOOD CANCER (TARGET II)</strong> - The present invention relates to a method ofmolecular docking of crystalline compound (C-I) with SARS-COV 2 proteins and its repurposing with proteins of blood cancer, comprising the steps of ; employing an algorithmto carry molecular docking calculations of the crystalized compound (C-I); studying the compound computationally to understand the effect of binding groups with the atoms of the amino acids on at least four target proteins of SARS-COV 2; downloading the structure of the proteins; removing water molecules, co enzymes and inhibitors attached to the enzymes; drawing the structure using Chem Sketch software; converting the mol file into a PDB file; using crystalized compound (C-I) for comparative and drug repurposing with two other mutated proteins; docking compound into the groove of the proteins; saving format of docked molecules retrieved; and filtering and docking the best docked results. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN320884617">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>新闻传播速度测评方法和系统</strong> - 本发明实施例提供一种新闻传播速度测评方法和系统，核心是基于新闻媒体权重计算新闻事件主题的传播速度，再通过聚类分析确定传播速度测评体系，最后评定新闻事件主题的传播等级。其中方法包括：确定待测评的新闻事件主题，获取新闻事件主题的新闻数据；基于新闻数据中每一新闻文本的传播媒体信息，计算新闻事件主题的初始传播速度；基于初始传播速度，以及预先设定的传播速度测评体系，确定新闻事件主题的传播速度等级；其中，传播速度测评体系包括多个传播速度等级与初始传播速度之间的对应关系。本发明实施例提供的方法和系统，实现了基于大数据的新闻事件舆情监测，能够有效提高新闻事件舆情响应效率，有利于决策管理者及时做出舆情应对。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN322592921">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AQUEOUS ZINC OXIDE NANOSPRAY COMPOSITIONS</strong> - Disclosed herein is aqueous zinc oxide nano spray compositions comprising zinc oxide nanoparticles and a synthetic surfactant for controlling the spread of Covid-19 virus. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN321836709">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bettverlängerungssystem</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Bettverlängerungssystem (1) für in Bauchlage beatmungspflichtige Patienten in Gestalt mit zumindest einer Platte (16), dadurch gekennzeichnet, dass die Platte (16) im Kopflagerungsbereich einen Luftwegezugangsdurchbruch (8) mit einem den Luftwegezugangsdurchbruch (8) umgebenden Auflagerbereich für ein durchbrochenes Kopfauflagepolster (14) aufweist, durch den von der Bettunterseite her und durch das Kopfauflagepolster (14) hindurch die Ver- und Entsorgungsschläuche für eine orotracheale Intubation oder eine nasotracheale Intubation ventral an das Gesicht des Patienten herangeführt werden können, und dass die Platte (16) im Bereich ihrer dem Kopfende eines Bettrosts (15) zugeordneten Stirnseite (6) ein Fixierelement (2) zur Befestigung der Platte (16) am Bettrost (15) nach Art eines einseitig frei über das Kopfende des Bettrosts hinausragenden Kragträgers aufweist.</p></li>
</ul>
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<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE322212040">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种肝素类药物组合物、喷鼻剂及其制备方法及应用</strong> - 本发明公开了一种肝素类药物组合物、喷鼻剂及其制备方法及应用。该肝素类药物组合物包括肝素钠和阿比朵尔。本发明中的肝素类药物组合物首次采用肝素钠和阿比朵尔联合使用，普通肝素钠联合1μM/L以上的阿比朵尔病毒抑制效率显著高于单独普通肝素钠或单独阿比多尔组（p&lt;0.05）。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN321712860">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USING CLINICAL ONTOLOGIES TO BUILD KNOWLEDGE BASED CLINICAL DECISION SUPPORT SYSTEM FOR NOVEL CORONAVIRUS (COVID-19) WITH THE ADOPTION OF TELECONFERENCING FOR THE PRIMARY HEALTH CENTRES/SATELLITE CLINICS OF ROYAL OMAN POLICE IN SULTANATE OF OMAN</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU320796026">link</a></p></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Bodies Piled High, Whatever Boris Johnson Said</strong> - The Prime Minister is known for his gaffes, but it’s hard to minimize the grief of the family members of those lost to COVID-19. - <a href="https://www.newyorker.com/news/letter-from-the-uk/the-bodies-piled-high-whatever-boris-johnson-said">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bargaining with China Today to Save the World Tomorrow</strong> - As climate czar, John Kerry has been tasked with a moral balancing act that few leaders have ever faced. - <a href="https://www.newyorker.com/news/daily-comment/bargaining-with-china-today-to-save-the-world-tomorrow">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biden’s Speech Offers an Alternative Vision for Democrats to Love</strong> - The President, channelling his inner Elizabeth Warren, pitches an American utopia after a dystopian plague year. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/bidens-speech-offers-an-alternate-reality-for-democrats-to-love-after-four-years-of-trumpian-fantasy">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Facebook and the Normalization of Deviance</strong> - The trouble with waiting to address problems long after you know that they exist. - <a href="https://www.newyorker.com/news/daily-comment/facebook-and-the-normalization-of-deviance">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Surviving the Crackdown in Xinjiang, in Mandarin</strong> - The New Yorker translates its recent report on China’s mass internment of Uyghurs and Kazakhs. - <a href="https://www.newyorker.com/news/news-desk/surviving-the-crackdown-in-xinjiang-in-mandarin">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Voters already love technology. They don’t need anti-China messaging to get there.</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/jeL91e_swqtIuImRFQHYKfXuDJ8=/0x0:2533x1900/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69226750/GettyImages_1232584905.0.jpg"/>
<figcaption>
U.S. President Joe Biden addresses a joint session of Congress in the House chamber of the U.S. Capitol April 28, 2021. In the speech he highlighted the need for increased investment in research and design and cast China as a key geopolitical adversary. | Melina Mara/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Poll: Americans are tech optimists.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9SvU7H">
In his address to the joint session of Congress on April 28, President Joe Biden made the case for reinvigorating the government’s role in technological investment, laying out a vision for what you could call “<a href="https://www.vox.com/2021/4/28/22408111/winners-and-losers-biden-joint-session-speech">progressive tech optimism</a>”: the idea that government investment in tech is the path forward to solving Democratic priorities like the climate crisis and developing treatments for illnesses like Alzheimer’s, diabetes, and cancer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q0Y2fl">
The president’s vision for the role of technology was striking given that both Republicans and Democrats have become incensed by the behavior of different big tech companies and their founders — from Amazon’s treatment of its workers and Twitter’s decision to ban former President Donald Trump. But while both sides of the aisle have been critical of tech companies lately, tech optimism resonates strongly with voters, according to a <a href="https://www.filesforprogress.org/datasets/2021/4/dfp-vox-endless-frontier-splits.pdf">new poll with Data for Progress (DFP) and Vox</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vyOMs7">
The poll, conducted between April 16 and 19, surveyed 1,138 likely voters. It found 80 percent of respondents agreed with the relatively anodyne statement: “Technology is generally a force for good,” and then, when given both tech optimist and tech pessimist messages, voters again agreed that tech is a force for good.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/4a2Ia47Ev9aIue64Z9xp25uDHno=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22481151/image__15_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PSvONs">
Seventy-one percent of likely voters agreed with the tech-optimist statement: “Technology is generally a force for good. Large tech companies have provided innovations like vaccines, electric vehicles, bringing down the cost of batteries that store green energy, vegetarian meat options, and other ways that have improved our quality of life.” Only 19 percent agreed with the tech-pessimist statement: “Technology is generally a force for bad. Large tech companies are bad for workers, inequality, and democracy. The technological innovations they produce are not worth the cost.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZOkMef">
Republicans, perhaps scarred by the wave of tech companies that banned Trump and some of his allies from their platforms, are more likely to agree with the tech-pessimist statement: 30 percent of Republicans as opposed to only 12 percent of Democrats. Still, 59 percent of Republicans agreed with the tech-optimist message along with 78 percent of Democrats.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gOxlnc">
Traditionally, presidents of both parties have argued in favor of pursuing new technological advancements by citing America’s need to remain “first” in the world. And in their fight for increased funding for technological research and development, Democrats have repeatedly highlighted China as a growing adversary. This new survey data suggests specific appeals about the danger any one country poses to dominance are likely unnecessary in garnering public support.
</p>
<h3 id="we3f7O">
Does public support for investing in R&amp;D require anti-China rhetoric?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PHlThI">
Bipartisan messaging pitting the US’s future against China’s <a href="https://www.vox.com/22350402/biden-infrastructure-plan-foreign-policy-china">has taken root</a>. In his joint address, Biden warned that “China and other countries are closing in fast” as he urged Congress to increase public investments in research and development.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="niPJer">
He’s not alone in this.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xZMF3k">
The Endless Frontier Act, a bill championed by Senate Majority Leader Chuck Schumer, seeks to “bolster US technology research and development efforts in a bid to address Chinese competition,” Reuters’ David Shepardson <a href="https://www.reuters.com/article/us-usa-china-technology/u-s-senate-panel-to-hold-hearing-on-tech-bill-to-combat-china-idUSKBN2BU3A8">reported</a>. Schumer himself has repeatedly warned of the threat the Chinese Communist Party poses as he urges his colleagues to support the legislation — in one <a href="https://www.democrats.senate.gov/newsroom/press-releases/majority-leader-schumer-senator-young-and-representatives-khanna-and-gallagher-introduce-endless-frontier-act-with-12-bipartisan-senators-and-5-representatives-to-dramatically-increase-us-investment-and-leadership-in-science-and-tech-innovation-strengthen-economic-and-national-security-and-keep-the-us-strategically-competitive-with-china-and-other-countries">statement</a>, he references China three times.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8Xmyjt">
Some <a href="https://twitter.com/DecampDave/status/1387587048601706496?s=20">commentators</a> have <a href="https://twitter.com/JordanUhl/status/1387808873571045376?s=20">criticized</a> the rise in this oppositional rhetoric, pointing to the attacks on AAPI people over the past year; <a href="https://twitter.com/rokwon/status/1387849289527795713?s=20">author R.O. Kwon</a> called Biden’s remarks before Congress “absolutely fucking terrifying.” Trump has been widely excoriated for referring to Covid-19 as the “China virus” or “Kung flu” — rhetoric which may have fueled the flames of anti-Asian sentiment over the last year — and these critics feel Democrats’ language isn’t helping matters.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m7BBap">
In the new poll, DFP and Vox tested whether this focus on China was necessary to build public support for new technological investments. Respondents were divided into two groups: In the first, respondents were told that increasing public investment in science and tech would help in “maintaining our competitive edge over China.” In the second, they were told it would help in “maintaining our competitive edge over Europe.” Support for the anti-China message was nearly indistinguishable from the anti-Europe one.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/FeHU2lpa_3-OfgeWVUuTp8MAojQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22481135/image__14_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7rZiax">
The study found 66 percent of respondents agreed that the US should “invest more in scientific and technological innovations” when they were told it would help the nation compete with China and 67 percent agreed with that statement when they were told it would help the nation compete with Europe. Looking at the partisan split, Republicans and Democrats are actually more motivated (4 percentage points and 2 percentage points, respectively) by competition with Europe.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ATvCSb">
In pursuit of drumming up public support for public investments in R&amp;D, voters may be motivated by the desire to maintain American hegemony, but specific references to China do not appear to increase support for the policies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rTFhb1">
But, as Vox’s Ella Nilsen and Alex Ward <a href="https://www.vox.com/22350402/biden-infrastructure-plan-foreign-policy-china">report</a>, Democrats’ anti-China rhetoric may not be about convincing the public but rather a way to get Republican elected officials on board:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IaJUv2">
“The best way to enact a progressive agenda is to use China [as a] threat,” a Democratic congressional aide told Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tPPNww">
The theory that America is at its best when it’s united against a common adversary can motivate members of both parties, especially using the idea that the US will lose its competitive edge or cede ground to another country. Indeed, one of the few things both parties can agree on is the need to compete with China.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OG2qg2">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="99ZYzZ">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FlwyVJ">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="q7CbPW">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="q1janC">
</p></li>
<li><strong>Are we really in for a summer of love? A post-vaccine dating investigation.</strong> -
<figure>
<img alt="A kissing couple silhouetted against a twilit sky." src="https://cdn.vox-cdn.com/thumbor/f2n5MO9iuy2Eo45UkrwZfTDPN9c=/0x0:3315x2486/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69226705/GettyImages_1222218688.0.jpg"/>
<figcaption>
How much kissing will happen this summer? | Annette Riedl/picture alliance via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Dating podcasters, condom companies, bartenders, and college students weigh in on the horny months to come.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XpUhmM">
“I’m excited to go a bit buck wild and feel so much safer,” says Elena, a recently vaccinated college student. “Just go on a lot of dates, make out with some guys, nothing serious.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ok41EE">
The 20-year-old Salt Lake City resident, who asked that her last name be withheld to protect her privacy, is ready to make up for lost time in her romantic life. She did some app dating during the pandemic, but Covid-19 was a constant presence, with several of her dates later telling her they’d been exposed (though she never caught the coronavirus). During quarantine, Elena spent time rehashing missed chances in her love life. “I was just thinking, ‘When I’m out of this, I’m going to make the most of every opportunity,’” she says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="byxEjM">
In Manhattan, Marc Hernandez, a bartender at the cocktail bar Ampersand, says that even at 50 percent capacity, the scene — “which has always been one for first dates” — is already feeling like its pre-Covid days. “That gets me thinking that the summer is going to be a little wild,” he says.
</p>
<div class="c-float-right">
<aside id="vcD51W">
<q>“When I’m out of this, I’m going to make the most of every opportunity”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CR22bV">
“<a href="https://www.refinery29.com/en-us/go-off-sis-season-4-jessica-franklin">Shot girl summer</a>.” “<a href="https://twitter.com/GrillmoreSlim/status/1379184293138857986">Vaxxed and waxed</a>.” The “whoring 20s.” As the US becomes increasingly inoculated and the weather continues to warm, the number of Americans who are ready to date is on the rise: A Morning Consult survey for the week ending April 25 found that 53 percent of adults feel “comfortable” dating right now, <a href="https://www.businessinsider.com/men-feel-more-comfortable-dating-in-the-pandemic-than-women-2021-4">up 9 percent</a> from the last week in March (although women still feel less comfortable than men). Everyone from <a href="https://twitter.com/andrewyang/status/1382326738097741827">Andrew Yang</a> to the bidet company Tushy — which is maintaining a herd-immunity countdown clock at <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fhellotushy.com%2Fpages%2Fcan-we-eat-ass-yet&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2Fthe-goods%2F22410017%2Fdating-post-vaccine-kinsey-relationships-hookups" rel="sponsored nofollow noopener" target="_blank">CanIEatAssYet.com</a> — are building anticipation for a hedonistic release of pent-up sexual energy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ipgDz1">
“<a href="https://www.insider.com/hot-vaxx-summer-pandemic-horniness-is-coming-blissful-release-2021-3">Hot vax summer is coming</a>,” Insider proclaimed in March. “<a href="https://nypost.com/2021/04/08/nyc-singles-ready-for-2021s-slutty-summer-of-casual-sex/">NYC singles ready for ‘slutty summer’ of casual sex</a>,” screamed the New York Post. Clearly, many are ready to throw themselves back into the social melee. “<a href="https://www.webmd.com/lung/news/20200615/how-to-cope-when-covid-steals-loving-touch-hugs">Touch starvation</a>” is real, and it can increase stress, depression, and anxiety. But after a year of such intense isolation, fear, suffering, and grief — and as the pandemic continues to rage across many parts of the world — the answer to how people will try to make up for lost time and lost touch is more complex than the orgiastic fantasy hawked by <a href="https://www.vox.com/the-goods/22334165/brands-post-pandemic-advertising">Suitsupply</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EmnZml">
According to psychologist <a href="https://kinseyinstitute.org/about/profiles/agesselman.php">Amanda Gesselman</a>, associate director for research at Indiana University’s <a href="https://kinseyinstitute.org/about/index.php">Kinsey Institute</a>, the pandemic has motivated American singles to look for partners rather than casual sex. While “there will [certainly] be people having the time of their lives” when it’s safe to do so, Gesselman says, “we actually found that people are less interested in no-strings-attached sex than they used to be.” In a recent Kinsey Institute <a href="https://blogs.iu.edu/kinseyinstitute/2021/04/21/new-study-on-post-pandemic-sex/">study on post-pandemic sex</a> (conducted in partnership with Cosmopolitan<em> </em>and Esquire),<em> </em>which surveyed 2,000 Americans between the ages of 18 and 45, more than half — 52 percent — of singles said they want to find a committed relationship post-pandemic, while about only one in 10 said they’re looking for no-strings-attached sex.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9zTNXV">
“That was a bit lower than we expected, considering everyone’s locked up and has been for a year,” Gesselman says. That said, as most people have spent more than a year worrying about infection and thinking about how to protect themselves from germs, she reasons the mindset “might be extending to sex with unfamiliar partners.”
</p>
<div class="c-float-left">
<aside id="rI7qsV">
<q>“We actually found that people are less interested in no-strings-attached sex than they used to be”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="icZeCx">
Ilana Dunn, co-host of the dating podcast <a href="https://open.spotify.com/show/1WbueOKKqctpjJGcgdNfyW"><em>Seeing Other People</em></a>, says she’s been hearing similar feedback from listeners and friends. “Everyone’s like, ‘Yeah, of course, I’m going to get really drunk and go wild for like, a week. Because we need to do that. But my goal is to find someone.’” In an Instagram poll that received more than 1,000 responses, Dunn says she was surprised to see 88 percent say that as people get vaccinated and the world opens up, they feel more inclined to look for something serious, while 52 percent said they’ll be open to hookups once they’re vaccinated.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5L69Sj">
Gesselman believes the pandemic has pushed many people to be more introspective about what they want in their lives, particularly <a href="https://www.vox.com/first-person/22169447/coronavirus-pandemic-2020-young-adulthood-twenties">younger adults</a>. “When you’re in your mid-20s and you have your entire future ahead of you, and then you just sat through an entire year of social isolation and halted progress, it really makes you think about the things you want in your life,” she says. “I think a lot of people are thinking more towards what would make their future the best rather than what would be good short-term gratification.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aircCo">
Meanwhile, condom companies are cautiously hopeful demand for their products will continue to grow along with the vaccinated portion of the US population. Male contraceptives saw a 2.5 percent uptick in sales at the beginning of April, according to Ken DeBaene, <a href="http://www.lifestyles.com/">LifeStyles’</a> vice president of sales in the Americas, who says he’s “optimistic this is a return to more normalized consumption levels.” (Between late March and mid-April, the sexual wellness industry overall saw a 4 percent sales bump.) LifeStyles is looking at returns to employment in the hospitality and service industries, as well as colleges’ fall opening plans, to help anticipate demand, DeBaene added.
</p>
<div class="c-float-right">
<div id="DIFcNU">
<div>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A2QiOd">
At <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fwww.mylola.com%2F&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2Fthe-goods%2F22410017%2Fdating-post-vaccine-kinsey-relationships-hookups" rel="sponsored nofollow noopener" target="_blank">LOLA</a>, a feminine care and sexual wellness company, chief marketing officer Monica Belsito says both “self-play and partner play” have been prevalent this year, with the brand seeing a 40 percent spike in lubricant sales and a record number of preorders for its new vibrator. However, as vaccinations of younger populations increase, the company “expects STI protection to steadily increase, creating a demand spike in condoms this summer and fall.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wiZEMR">
Many people are also searching for a historical precedent that can shed light on what awaits us in the post-Covid recovery period, from the Roaring ’20s — when the nation indulged after the ravages of World War I and the 1918 pandemic — to 1967’s Summer of Love, when tens of thousands of young people gathered in San Francisco to listen to rock ’n’ roll, experiment with sex and drugs, and protest the Vietnam War.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4RoYQT">
“If you look at the middle to late 1960s as an opening up after a period of considerable repression in the ’50s, I think the parallel is not unreasonable,” says historian <a href="https://www.dennismcnally.com/">Dennis McNally</a>, who also worked as a publicist for the Grateful Dead. However, he points to the FDA’s 1960 approval of the first birth control pill as a key influence in the sexual liberation movement that climaxed that summer. Even after <a href="https://www.buzzfeednews.com/article/katebubacz/miami-spring-break-parties-curfew-covid">seeing the hordes</a> of spring breakers that descended upon Miami in March, before vaccines were widely available to younger adults, McNally isn’t convinced the vigilant “pandemic safety” mindset will be banished with vaccines. “The message of all of this is that reality is dangerous, which is a very repressive lesson, and it’s going to take a while, I think, to unlearn that lesson and be able to go out and relax,” he says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YlwJhO">
As for the Roaring ’20s comparison <a href="https://www.theguardian.com/world/2020/dec/21/epidemiologist-1918-flu-pandemic-roaring-20s-post-covid">often attributed</a> to social epidemiologist Dr. Nicholas Christakis, the timeline he’s laid out doesn’t predict a pendulum swing away from the risk aversion of the present moment until 2024, when vaccines will have been distributed around the world and there’s been more of a recovery from some of the pandemic’s economic devastation. He sees this summer as having the potential to offer “a taste of the past and a hope for the future,” Christakis recently told <a href="https://www.npr.org/2021/04/17/987865318/life-in-the-roaring-2020s-young-people-prepare-to-party-reclaim-lost-pandemic-ye">NPR</a>.
</p>
<div class="c-float-left">
<aside id="Z9eV9Y">
<q>“People go on a date and nobody knows how to talk about anything besides Covid”</q>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2swEkM">
Gesselman and Dunn also cite lingering pandemic-induced social anxiety as another obstacle to a bacchanal this summer. “A lot of people didn’t date last year, and I keep hearing from our listeners that people go on a date and nobody knows how to talk about anything besides Covid, and it’s not leading to good date conversations,” Dunn says. And in Gesselman’s research, one of the top fears respondents have cited is not having the ability to protect their own mental health as they reemerge from quarantine. “It seems like people’s biggest concern is when life opens back up and they’re finally able to pursue these connections, ‘What if I get rejected or things go wrong? What happens if disappointment strikes?’” Gesselman says.
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Elena, the college student who’s excited to get back to more carefree dating, is also wary of <a href="https://www.vox.com/the-goods/22336425/summer-2021-post-pandemic-vaccine-hot-girl">the expectations</a> she and many of her peers are putting on this post-vaccine summer. “I do think people have very, very high expectations, because you kind of need to live your entire life that’s been put on hold for the past year all in this summer, and if they’re not met it’s going to be tough,” she says. “But I think for the most part, people are really down to do anything.”
</p></li>
<li><strong>Republicans feared Democrats’ voting bill polls well. A new poll says they’re right.</strong> -
<figure>
<img alt="Sen. Jeff Merkley, Senate Majority Leader Chuck Schumer, and Sen. Amy Klobuchar outside the Capitol." src="https://cdn.vox-cdn.com/thumbor/ze_FxAEqtbrmgzorPlhaXRu6JeU=/364x0:7280x5187/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69226665/GettyImages_1307603470.0.jpg"/>
<figcaption>
Sen. Jeff Merkley, Senate Majority Leader Chuck Schumer, and Sen. Amy Klobuchar outside the Capitol on March 17, 2021. | Getty Images
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</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
When partisan cues aren’t present, voters say they like many ideas in the For the People Act.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RLywAB">
Back in March, the New Yorker’s Jane Mayer <a href="https://www.newyorker.com/news/news-desk/inside-the-koch-backed-effort-to-block-the-largest-election-reform-bill-in-half-a-century">obtained a recording</a> of an adviser to Mitch McConnell privately bemoaning, on a call with conservative group leaders, that Democrats’ big voting rights bill, the <a href="https://www.vox.com/22346812/voting-rights-bill-hr1-for-the-people-act">For the People Act</a>, polled quite well. “When presented with a very neutral description” of it, “people were generally supportive,” the adviser said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9noxIy">
A new <a href="https://www.filesforprogress.org/datasets/2021/4/dfp-vox-hr-1.pdf">Data for Progress poll</a> conducted as part of a partnership with Vox backs up that assessment. The poll surveyed 1138 likely voters nationally between April 16 to April 19, and it finds that much of what the 800-page bill claims to do is overwhelmingly popular.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hA8ImM">
More than 80 percent of respondents said they supported preventing foreign interference in elections, limiting the influence of money in politics, and modernizing election infrastructure to increase election security. More than 60 percent of respondents supported requiring nonpartisan redistricting commissions, a 15-day early voting period for all federal elections, same-day registration for all eligible voters, automatic voter registration for all eligible voters, and giving every voter the option to vote by mail.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hsejXb">
There are, of course, a few caveats. The poll presented these questions without partisan cues about which party supports which proposal. Indeed, the one question that mentioned the parties — about whether Democrats should change Senate rules so they could pass redistricting reform without Republican support — was much more closely divided. (Forty-seven percent of respondents said they supported doing this, and 42 percent said they opposed it.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6vvtB8">
The questions also didn’t spotlight Republicans’ preferred arguments — for instance, Republicans would stress concerns that same-day and automatic registration could allow ineligible people to vote, which would likely make some respondents more concerned about these proposals.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QziDPi">
And other parts of the bill not asked about in this poll, like its limits to voter ID laws (it would allow voters without ID to submit a sworn statement vouching for their identity) and its creation of a public financing system to match small donations, may be more controversial. Voter ID requirements <a href="https://fivethirtyeight.com/features/americans-oppose-many-voting-restrictions-but-not-voter-id-laws/">generally poll quite well</a> and public financing often <a href="https://twitter.com/EchelonInsights/status/1374755869322321924">polls poorly</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UkuiF4">
The poll also asked about a competing redistricting reform proposal not currently in the For the People Act — setting proportional standards such that, if a party wins about half of votes in a state, it should win about half the seats. (I <a href="https://www.vox.com/22346812/voting-rights-bill-hr1-for-the-people-act">recently wrote about</a> the debate among Democrats over this idea). This got less support than any of the other provisions above but still was backed by 51 percent of poll respondents, with 34 percent saying they opposed this.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G2qd5R">
In any case, Democrats’ problem when it comes to enacting the For the People Act isn’t the polls — it’s the Senate filibuster. The bill that already passed in a near party-line vote in the House will require a 60-vote supermajority to pass in the Senate. Since no Republican support appears to be in the offing, activists have argued that the Senate should change its rules to let the bill pass. But moderate Democratic senators don’t want to do this.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9ek6BS">
One key holdout, Joe Manchin, told me <a href="https://www.vox.com/22339531/manchin-filibuster-bipartisanship-senate-west-virginia">in a recent profile</a> that he fears passing a major voting bill on party lines would only further divide the country. He argued that 20 to 25 percent of the public already doesn’t trust the system and that a party-line overhaul would “guarantee” that number would increase, leading to more “anarchy” like that at the Capitol on January 6. He added, “I just believe with all my heart and soul that’s what would happen, and I’m not going to be part of it.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="53ObOX">
Unless he changes his mind, the For the People Act can’t pass the Senate.
</p>
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</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2021 | No charter flight for Australia players at this moment: Cricket Australia chief</strong> - On Monday, two KKR players tested positive for COVID-19</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sri Lanka all-rounder Thisara Perera retires from international cricket</strong> - Thisara Perera has represented Sri Lanka in six Tests, 166 ODIs and 84 T20s.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2021: KKR-RCB match rescheduled after two players test positive for COVID-19</strong> - Confirming that today’s match has been rescheduled, a statement issued by IPL said the KKR camp will be tested on a daily basis now</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2021 | Resurgent Mumbai Indians favourites against SunRisers Hyderabad</strong> - Mumbai Indians openers Rohit Sharma and Quinton De Kock would be itching to give the five-time champions another strong platform and also convert their starts into big scores</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Man United-Liverpool match postponed after fans storm pitch</strong> - While the protest had been planned and was largely peaceful, it descended into chaos as fans infiltrated the stadium.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Op CO-JEET launched by armed forces to fight COVID-19 in India: Lt. Gen. Kanitkar</strong> - Lt. Gen. Madhuri Kanitkar, who is the third woman to become a three-star general in the armed forces, is working round the clock to strategise and monitor steps to provide relief to COVID-19 patients</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>West Bengal Assembly polls | This is Mamata Banerjee’s victory over Modi and Shah: Derek O’ Brien</strong> - We will get all parties together to demand reforms in the functioning of the EC, says TMC MP</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Congress seeks judicial probe into COVID deaths</strong> - The Opposition Congress has demanded a judicial probe into the death of 23 COVID-19 patients at the district hospital in Chamarajanagar, allegedly owi</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phone tapping: IPS officer Rashmi Shukla moves Bombay HC against FIR</strong> - Senior IPS officer Rashmi Shukla’s advocate sought an urgent hearing of the plea, saying the petitioner was apprehending arrest in the case.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘Ullam’ narrates the plight of women through a song about lost love</strong> - Composed and sung by Pranav CP, the song is about a relationship that gets burnt at the altar of inequality</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Child sexual abuse: Four held in German-led raid on huge network</strong> - German police say a dark web club for sharing images of child sex abuse had more than 400,000 users.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>EU unveils plans for overseas tourists to return</strong> - The proposals will allow fully vaccinated non-EU travellers to enter for non-essential purposes.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: French lockdown eased to help schools and travel</strong> - Most French secondary pupils return to class and a domestic travel ban is lifted.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rome Colosseum: Italy unveils plan for new floor with gladiator’s view</strong> - Work on a wooden, retractable floor at the Roman landmark is expected to be finished by 2023.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sarah Halimi: How killer on drugs escaped French trial for anti-Semitic murder</strong> - The decision not to prosecute a Jewish woman’s killer because of his drug use sparks a legal row in France.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Ars Technica Mother’s Day 2021 gift guide</strong> - Who needs flowers? We pick out a few gadgets to make Mom’s life more convenient. - <a href="https://arstechnica.com/?p=1761492">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Invincible S1: Clearly TV’s most fun superhero shows are on Amazon these days</strong> - Not even <em>Smallville</em> could combine YA drama and superhero DNA this well. - <a href="https://arstechnica.com/?p=1761469">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Will Virgin Galactic ever be successful? A new book provides insights</strong> - “It’s hard to make decisions around here sometimes.” - <a href="https://arstechnica.com/?p=1761463">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why are game-makers creating new Game Boy games in 2021?</strong> - New tools and wide-eyed nostalgia are driving a monochrome portable renaissance. - <a href="https://arstechnica.com/?p=1761698">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How one naughty bird cheats with fancy feather structures</strong> - Male tanager birds have more than one way to make their colors really pop for the ladies. - <a href="https://arstechnica.com/?p=1761656">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Three men walk into a bar. One works for Budweiser, one works for Corona, and one works for Guinness.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“What would you like?” the bartender asks the Budweiser worker.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I’ll have a Budweiser,” says the Budweiser worker.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“And you?” the bartender asks the Corona worker.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I’ll have a Corona,” responds the Corona worker.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Let me guess,” the bartender says to the Guinness worker, “you’d like a Guinness?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“No thank you,” comes the reply. “I’ll just have some water.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Water?” The bartender is taken aback. “Why not Guinness?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Because,” says the Guinness worker, “if the other two aren’t gonna have beer, I’m not gonna have it either.”
</p>
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/wimpykidfan37"> /u/wimpykidfan37 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n3n464/three_men_walk_into_a_bar_one_works_for_budweiser/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n3n464/three_men_walk_into_a_bar_one_works_for_budweiser/">[comments]</a></span></p></li>
<li><strong>What did Yoda say when he saw himself in 4k?</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
HDMI
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/DaDank_69"> /u/DaDank_69 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n3g6f4/what_did_yoda_say_when_he_saw_himself_in_4k/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n3g6f4/what_did_yoda_say_when_he_saw_himself_in_4k/">[comments]</a></span></p></li>
<li><strong>A man goes to a hospital and sees a man masturbating.</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He asks the nurse why is he doing so. The nurse explains to him that if he doesn’t masturbate every 6 hours there would be a clot and he would die. Then in the next room, he sees a nurse giving a blowjob to a guy. He then says, “You will have to explain this.” The nurse replies, “Same problem better insurance.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/samiransamantroy"> /u/samiransamantroy </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n365in/a_man_goes_to_a_hospital_and_sees_a_man/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n365in/a_man_goes_to_a_hospital_and_sees_a_man/">[comments]</a></span></p></li>
<li><strong>Why did the sperm cross the road? (NSFW)</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Cause I put on the wrong sock this morning.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Bigpapanasty432"> /u/Bigpapanasty432 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n3jrye/why_did_the_sperm_cross_the_road_nsfw/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n3jrye/why_did_the_sperm_cross_the_road_nsfw/">[comments]</a></span></p></li>
<li><strong>Three babies in the womb discuss what they would like to be when they grow up.</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Three babies in the womb discuss what they would like to be when they grow up. The first one says, “I wanna be a plumber, so I can fix the pipes in here.” The second one says, “I wanna be an electrician, so I can get some lights in here.” The third one says, “I wanna be a boxer.” The others look confused and ask, “Why do you want to be a boxer?” He proudly replies, “So I can beat the hell out of that rude bald guy who keeps coming in here and spitting on us.”
</p>
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/JuliaSeth"> /u/JuliaSeth </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/n3j6sx/three_babies_in_the_womb_discuss_what_they_would/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/n3j6sx/three_babies_in_the_womb_discuss_what_they_would/">[comments]</a></span></p></li>
</ul>
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