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174 lines
46 KiB
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<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
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<title>16 October, 2022</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-preprints">From Preprints</a></li>
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<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
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<li><a href="#from-pubmed">From PubMed</a></li>
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<li><a href="#from-patent-search">From Patent Search</a></li>
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<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
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<li><strong>Serology assays used in SARS-CoV-2 seroprevalence surveys worldwide: a systematic review and meta-analysis of assay features, testing algorithms, and performance</strong> -
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Background: Many SARS-CoV-2 serological assays were rapidly developed during the COVID-19 pandemic. However, differences in detection mechanism limit the comparability of assay outputs. Methods: As part of the SeroTracker global living systematic review of SARS-CoV-2 seroprevalence studies, we collated serological assays used in serosurveys between January 1, 2020 and November 19, 2021. We mapped performance metrics to the manufacturer, third-party head-to-head, and independent group evaluations, comparing the assay performance data using a mixed-effect beta regression model. Results: Among 1807 serosurveys, 192 distinctive commercial assays and 380 self-developed assays were identified. According to manufacturers, 28.6% of all commercial assays met WHO criteria for emergency use (sensitivity [Sn.] >= 90.0%, specificity [Sp.] >= 97.0%). Third-party and independent evaluations indicated that manufacturers overstated the Sn. of their assays by 5.4% and 2.8%, and Sp. by 6.3% and 1.2%. We found in simulations that inaccurate Sn. and Sp. can substantially bias seroprevalence estimates corrected for assay performance. Conclusions: The Sn. and Sp. of the serological assay are not fixed properties, but varying features depending on testing population. To achieve precise population estimates and to ensure comparability, serosurveys should select assays with strong, independently validated performance and adjust seroprevalence estimates based on assured performance data.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.10.13.22280957v1" target="_blank">Serology assays used in SARS-CoV-2 seroprevalence surveys worldwide: a systematic review and meta-analysis of assay features, testing algorithms, and performance</a>
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</div></li>
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<li><strong>Stability of SARS-CoV-2 spike antigens against mutations</strong> -
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Modern health care needs preventive vaccines and therapeutic treatments with stability against pathogen mutations to cope with current and future viral infections. At the beginning of the COVID-19 pandemic, our analytic and predictive tool identified a set of eight short SARS-CoV-2 S-spike protein epitopes that had the potential to persistently avoid mutation. Here a combination of genetic, Systems Biology and protein structure analyses confirm the stability of our identified epitopes against viral mutations. Remarkably, this research spans the whole period of the pandemic, during which 93.9% of the eight peptides remained invariable in the globally predominant 43 circulating variants, including Omicron. Likewise, the selected epitopes are conserved in 97% of all 1,514 known SARS-CoV-2 lineages. Finally, experimental analyses performed with these short peptides showed their specific immunoreactivity. This work opens a new perspective on the design of next-generation vaccines and antibody therapies that will remain reliable against future pathogen mutations.
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</p>
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.10.13.22280980v1" target="_blank">Stability of SARS-CoV-2 spike antigens against mutations</a>
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<li><strong>The SARS-CoV-2 spike N-terminal domain engages 9-O-acetylated α2-8-linked sialic acids</strong> -
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<div>
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SARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor-binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan-binding cleft. However, for the SARS-CoV-2 NTD protein-glycan binding was only observed weakly for sialic acids with highly sensitive methods. Amino acid changes in the NTD of Variants of Concern (VoC) shows antigenic pressure, which can be an indication of NTD-mediated receptor binding. Trimeric NTD proteins of SARS-CoV-2, Alpha, Beta, Delta, and Omicron did not reveal a receptor binding capability. Unexpectedly, the SARS-CoV-2 Beta subvariant strain (501Y.V2-1) NTD binding to Vero E6 cells was sensitive to sialidase pretreatment. Glycan microarray analyses identified a putative 9-O-acetylated sialic acid as a ligand, which was confirmed by catch-and-release ESI-MS, STD-NMR analyses, and a graphene-based electrochemical sensor. The Beta (501Y.V2-1) variant attained an enhanced glycan binding modality in the NTD with specificity towards 9-O-acetylated structures, suggesting a dual-receptor functionality of the SARS-CoV-2 S1 domain, which was quickly selected against. These results indicate that SARS-CoV-2 can probe additional evolutionary space, allowing binding to glycan receptors on the surface of target cells.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.14.507904v2" target="_blank">The SARS-CoV-2 spike N-terminal domain engages 9-O-acetylated α2-8-linked sialic acids</a>
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</div></li>
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<li><strong>Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single cell resolution</strong> -
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Synthetic glucocorticoids, such as dexamethasone, have been used as treatment for many immune conditions, such as asthma and more recently severe COVID-19. Single cell data can capture more fine-grained details on transcriptional variability and dynamics to gain a better understanding of the molecular underpinnings of inter-individual variation in drug response. Here, we used single cell RNA-seq to study the dynamics of the transcriptional response to glucocorticoids in activated Peripheral Blood Mononuclear Cells from 96 African American children. We employed novel statistical approaches to calculate a mean-independent measure of gene expression variability and a measure of transcriptional response pseudotime. Using these approaches, we demonstrated that glucocorticoids reverse the effects of immune stimulation on both gene expression mean and variability. Our novel measure of gene expression response dynamics, based on the diagonal linear discriminant analysis, separated individual cells by response status on the basis of their transcriptional profiles and allowed us to identify different dynamic patterns of gene expression along the response pseudotime. We identified genetic variants regulating gene expression mean and variability, including treatment-specific effects, and demonstrated widespread genetic regulation of the transcriptional dynamics of the gene expression response.
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</div>
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.09.30.462672v3" target="_blank">Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single cell resolution</a>
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</div></li>
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<li><strong>TECHNOLOGY BASED LEARNING MODEL DURING THE COVID-19 PANDEMIC</strong> -
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The Covid-19 pandemic has not been completely handled in almost every country in the world up until the end of 2020, its impact was felt by Indonesia. The major changes that continue to occur in all aspects of human life are also targeting the education system. Changes in the education system in Indonesia have a very significant effect on learning and students, where students experience difficulties in following the learning process, especially students at the elementary level. It can be ascertained that the cause is due to the fact that learning is usually carried out conventionally, dominance is still centralized on the educators, and the models used do not vary much. Within a short time period and without preparation, learning must be adapted to the needs, situations and conditions, so that learning can still be carried out. Distance learning process (Pembelajaran Jarak Jauh) using online modes is expected to bridge the relationship and communication between educators and students so that the learning process does not experience obstacles. To make Distance Education implemented optimally, Distance Education cannot be separated from the utilization of Information Technology. This article aims to examine further how the implementation of Distance Education relies on technology, as well as the use of appropriate learning models for students during the Covid-19 pandemic, using descriptive-analytical literature methods. The results and conclusions in this paper indicate that technology-based learning has an important role in the implementation of learning, especially during the Covid-19 pandemic. The management and implementation of technology-based learning is very dependent on Information Technology, facilitating educators so that the continuity of interaction between educators and students does not face any problems. It is hoped that the competence of educators in managing Distance Education using online modes is expected to be continually developed by utilizing various learning models, so that the learning process can be optimized. Although in its implementation there are still several obstacles related to academic culture, including values, attitudes, knowledge, skills, and readiness of technology-related facilities and infrastructure, education management by utilizing various learning models and supporting technology can be one of the solutions in facing challenges of Distance Education during the current Covid-19 pandemic.
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🖺 Full Text HTML: <a href="https://osf.io/kwe59/" target="_blank">TECHNOLOGY BASED LEARNING MODEL DURING THE COVID-19 PANDEMIC</a>
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<li><strong>Examining the influence of user engagement on tourist virtual reality behavioral response from the human-computer interaction perspective: A PLSSEM-IMP-NN hybrid machine learning approach</strong> -
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Due to the impact of the COVID-19 pandemic, new attraction ways are tended to be adapted by compelling sites to provide tours product and services, such as virtual reality (VR) to visitors. Based on human-computer interaction (HCI) user engagement and domain segmentation innovativeness theory, we develop and test a theoretical framework using a hybrid partial least squares structural equation model (PLSSEM) with Importance Performance Matrix (IMP) and neural network machine learning approach (PLSSEM-IMP-NN) that examines key user engagement drivers of visitors’ attitude toward VR (ATT) and in-person tour intentions (ITI) during COVID-19. According to a sample of visitors’ response, the results demonstrate that a) user engagement including aesthetic appeal, focused attention, perceived usability, and reward experience, raise attitude toward VR; b) product-possessing innovativeness positively moderates the relationships between ATT and ITI; c) information-possessing innovativeness negatively moderates the relationships between ATT and ITI; d) ATT exert the mediating effect between user engagement and ITI. The proposed new PLSSEM-IMP-NN approach has been examined and denotes its efficient and effective in HCI and behavioral response assessment. Other contributions to theories and practical implications are discussed accordingly.
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</div>
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🖺 Full Text HTML: <a href="https://osf.io/hp259/" target="_blank">Examining the influence of user engagement on tourist virtual reality behavioral response from the human-computer interaction perspective: A PLSSEM-IMP-NN hybrid machine learning approach</a>
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<li><strong>Private sector involvement in social and affordable housing</strong> -
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This research investigates models for engaging private sector investors and developers in financing or delivering social and affordable housing, across different market segments and tenures in Australia and internationally. It also identifies key existing and potential players, and financial, regulatory, or development barriers to wider participation. Prior to the COVID-19 pandemic, around 3,000 social and affordable dwellings were being produced per year, against an estimated annual need of around 36,000 homes. To meet the forecast demand, it is clear ‘hybridity’ of the housing system is essential, whereby social and affordable housing is increasingly financed, developed and managed by a combination of government, community-based and market providers, and cross-sector partnerships; no one sector can address the need alone. This study highlighted that a range of established and emerging affordable housing product types can be supported through collaboration with private not-for-profit and for-profit partners. These strategies include public private partnerships, mixed tenure developments, tax subsidies for affordable supply, home ownership schemes, build to rent and inclusionary planning mechanisms. These depend on different combinations of government subsidy, policy settings, and regulation, and are suitable for delivery across a variety of different development contexts.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/9h6qj/" target="_blank">Private sector involvement in social and affordable housing</a>
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<li><strong>Misleading Beyond Visual Tricks: How People Actually Lie with Charts</strong> -
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Data visualizations can empower an audience to make informed decisions. At the same time, deceptive representations of data can lead to inaccurate interpretations while still providing an illusion of data-driven insights. Existing research on misleading visualizations primarily focuses on examples of charts and techniques previously reported to be deceptive. These approaches do not necessarily describe how charts mislead the general population in practice. We instead present an analysis of data visualizations found in a real-world discourse of a significant global event—Twitter posts with visualizations related to the COVID-19 pandemic. Our work shows that, contrary to conventional wisdom, violations of visualization design guidelines are not the dominant way people mislead with charts. Specifically, they do not disproportionately lead to reasoning errors in posters’ arguments. Through a series of examples, we present common reasoning errors and discuss how even faithfully plotted data visualizations can be used to support misinformation online.
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🖺 Full Text HTML: <a href="https://osf.io/ky6th/" target="_blank">Misleading Beyond Visual Tricks: How People Actually Lie with Charts</a>
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<li><strong>Joko Widodo Views on Women’s Interests Before and During the Pandemic Based on Social-Media</strong> -
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The COVID-19 Pandemic has had many impacts on Indonesian women. As one of the pilot countries for the HeForShe project campaigned by UN Women, it is interesting to analyze how the President of Indonesia responds to this phenomenon. Many studies focus on the impact of the COVID-19 Pandemic on women. But, there is a lack of research on how the government responds to women’s interests during the Pandemic compared to the situation before the Pandemic. Using a qualitative approach, this study analyses how the President of Indonesia views women’s interests before and during the COVID-19 Pandemic. Two official social-media of the President of Republic Indonesia Joko Widodo: The Official Twitter Account of the President of Indonesia @jokowi and The Official Facebook Account of The President of Indonesia @Jokowi · Minat are used as the primary data sources. The findings indicate that before the COVID-19 Pandemic, President Joko Widodo gave significant attention to strategic women’s interests such as subordination and gender equality. But the situation changed during the Pandemic. The President views the fulfillment of daily needs such as food and health as more urgent for women in the COVID-19 Pandemic than strategic interests. This study highlights that in a crisis, the focus of the government policy is safe for the people first (women and men) to fulfill their basic needs. The gender equality agenda is becoming marginalized.
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🖺 Full Text HTML: <a href="https://osf.io/p5kfu/" target="_blank">Joko Widodo Views on Women’s Interests Before and During the Pandemic Based on Social-Media</a>
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<li><strong>The Effect of Chairobic Dance Program on Cardiorespiratory Endurance in Faculty of Education Staff, Thaksin University</strong> -
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The COVID-19 pandemic has impacted all aspects of daily life, especially exercise, where restrictions on location, time, and work can make exercise even more difficult. Hence, this study aims to create a Chairobic dance program dancing with a chair that uses few spaces, able to sit and dance in your chair. It was developed from the aerobics dance. In addition, to compare the effect of the Chairobic dance program on Cardiorespiratory endurance before and after training. The target group is 24 staff of the Faculty of Education at Thaksin University. The participants were trained through a Chairobic dance program created by the researcher for eight weeks (3 days/week, i.e., Monday, Wednesday, and Friday). They have to practice 45 minutes a day after work. The Cardiorespiratory endurance was tested using a 3-minute knee-up and down test and compared before and after eight weeks of training by the Pair t-test statistics. The results showed that in the Chairobic dance program created by the researcher, there is an IOC (Index of Item-Objective Congruence) in the range of 0.6 -1.00, which is acceptable and usable. In addition, the target group had better Cardiorespiratory endurance than before training. Therefore, It will be helpful for anyone interested in an alternative to exercise. This is because it takes up less space, is convenient to exercise, fun, and can develop Cardiorespiratory endurance.
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🖺 Full Text HTML: <a href="https://osf.io/5g8wu/" target="_blank">The Effect of Chairobic Dance Program on Cardiorespiratory Endurance in Faculty of Education Staff, Thaksin University</a>
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<li><strong>Did the pandemic increase social media-induced appearance pressures? A longitudinal analysis of social media caused appearance-related pressures before and during the Covid-19 pandemic</strong> -
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Has the use of social media intensified and increased appearance-related pressures during the Covid-19 pandemic? A growing body of research has suggested that body image concerns and disordered eating have increased during the Covid-19 pandemic. One of the potential pathways includes an increase in social media use. However, examinations of this pathway have been limited because of the lack of longitudinal data. Drawing on a four-wave population-based survey, we demonstrate that social media-based appearance pressures did not increase at the beginning of the pandemic, but rather at the later stage, and among women only. However, the changes in social media use do not explain this subtle increase. These findings suggest that other pathways than intensified use of social media might be more useful in explaining increased appearance-related pressures during the Covid-19 pandemic.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/9q7xj/" target="_blank">Did the pandemic increase social media-induced appearance pressures? A longitudinal analysis of social media caused appearance-related pressures before and during the Covid-19 pandemic</a>
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<li><strong>Coping with Covid 19 lockdown: Optimism and Intolerance of Uncertainty in India</strong> -
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Background: Kerala state in India has been hailed as an exceptional model in containing the Covid 19 pandemic within a low resource setting Insights from such a setting are valuable for mental health research during an epidemic situation, especially for resource poor countries. Aims:The study examined the relationship between optimism intolerance of uncertainty (IU), and socio- demographic factors among participants from Kerala, India. Methods: An observational design was used and data was collected using online survey. Snowball sampling method was employed. Sample consisted of 121 adults belonging to Kerala. Standardised tools and customised questionnaire were used for data collection. Descriptive and inferential statistics were employed. Results: A strong relationship existed between inhibitory anxiety and optimism. Socio-demographic factors did not determine either intolerance of uncertainty or optimism. The unprecedented uncertainty brought about by the pandemic needs further exploration. Conclusions: The present pandemic has presented an unprecedented situation regarding well being of individuals. Further studies on anxiety and related issues, and protective factors during situations of uncertainty are needed for policy and practice related to community level disaster preparedness.
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🖺 Full Text HTML: <a href="https://osf.io/bzfp7/" target="_blank">Coping with Covid 19 lockdown: Optimism and Intolerance of Uncertainty in India</a>
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<li><strong>Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual</strong> -
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The worldwide pandemic caused by SARS-CoV-2 has remained a human medical threat due to the continued evolution of multiple variants that acquire resistance to vaccines and prior infection. Therefore, it is imperative to discover monoclonal antibodies (mAbs) that neutralize a broad range of SARS-CoV-2 variants for therapeutic and prophylactic use. A stabilized autologous SARS-CoV-2 spike glycoprotein was used to enrich antigen-specific B cells from an individual with a primary Gamma variant infection. Five mAbs selected from those B cells showed considerable neutralizing potency against multiple variants of concern, with COVA309-35 being the most potent against the autologous virus, as well as against Omicron BA.1 and BA.2. When combining the COVA309 mAbs as cocktails or bispecific antibody formats, the breadth and potency was significantly improved against all tested variants. In addition, the mechanism of cross-neutralization of the COVA309 mAbs was elucidated by structural analysis. Altogether these data indicate that a Gamma-infected individual can develop broadly neutralizing antibodies.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.10.14.512216v1" target="_blank">Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual</a>
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<li><strong>Computational Prediction of Binding Affinities of Human Angiotensin Converting Enzyme-2 with SARS-CoV-2 Spike Protein Variants: Omicron Variants and Potentially Deleterious Mutations</strong> -
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The Omicron variant (BA.1) and its sub-variants of the SARS-CoV-2 virus which causes the COVID-19 disease continues to spread across the United States and the World at large. As new sub-variants of SARS-CoV-2 continue to proliferate, a reliable computational method of quickly determining the potential infectivity of these new variants is needed to assess their potential threat. In the present study, we have tested and validated an efficient computational protocol, which includes an efficient energy minimization and subsequent molecular mechanics/Poisson Boltzmann surface area (MM-PBSA) calculation of the binding free energy between the SARS-CoV-2 spike protein and human angiotensin converting enzyme-2 (ACE2), to predict the binding affinities of these spike/ACE2 complexes based upon the calculated binding free energies and a previously calibrated linear correlation relationship. The predicted binding affinities are in good agreement with available experimental data including those for Omicron variants, suggesting that the predictions based on this protocol should be reasonable. Further, we have investigated several hundred potential mutations of both the wildtype and Omicron variants of the SARS-CoV-2 spike protein. Based on the predicted binding affinity data, we have identified several mutations that have the potential to vastly increase the binding affinity of the spike protein to ACE2 within both the wildtype and Omicron variants.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.10.14.512203v1" target="_blank">Computational Prediction of Binding Affinities of Human Angiotensin Converting Enzyme-2 with SARS-CoV-2 Spike Protein Variants: Omicron Variants and Potentially Deleterious Mutations</a>
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<li><strong>TCID50 Measurements of anti-viral efficacy on metal printed masks and plastic surfaces</strong> -
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The SARS-CoV-2 pandemic has created a need for effective personal protective equipment (PPE) to prevent viral spread. PPE like face masks contain the spread of virus-filled droplets and thus reduce infection rates, has been a critical tool in stopping the spread of SARS-CoV-2. PET plastic barriers have also been used in public settings to reduce face to face viral transmission. However, in some cases, they have provided additional contact with the virus due to contamination. In order study, we evaluated the effectiveness of face masks and PET plastics coated in different metals in reducing viral load. We compared PPE printed with silver, copper, or zinc for their ability to inactivate live human coronavirus HCoV 229E. Our results show that silver and copper have significant anti-viral efficacy when printed on nonwoven fabric compared to the controls. The metal-printed PET showed around 70% anti-viral efficacy with any formulations, with copper performing the best. This work builds more data to support the development of metal printed materials for enhanced protection against coronaviruses.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.10.13.512105v1" target="_blank">TCID50 Measurements of anti-viral efficacy on metal printed masks and plastic surfaces</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Learn About a Repeat 5-Day Treatment With the Study Medicines (Called Nirmatrelvir/Ritonavir) in People 12 Years Old or Older With Return of COVID-19 Symptoms and SARS-CoV-2 Positivity After Finishing Treatment With Nirmatrelvir/Ritonavir</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: nirmatrelvir; Drug: ritonavir; Drug: placebo for nirmatrelvir<br/><b>Sponsor</b>: Pfizer<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recombinant Omicron-Delta COVID-19 Vaccine (CHO Cell)</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: Recombinant Omicron-Delta COVID-19 Vaccine (CHO Cell); Biological: Inactivated COVID-19 vaccine (Vero Cell)<br/><b>Sponsors</b>: Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.; First Affiliated Hospital Bengbu Medical College<br/><b>Active, not recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase III Study to Evaluate Immunogenicity and Safety of COVID-19 Vaccine EuCorVac-19 in Healthy Adults</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: EuCorVac-19; Biological: ChAdOx1<br/><b>Sponsor</b>: EuBiologics Co.,Ltd<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study Evaluating Diltiazem in Combination With Standard Treatment in the Management of Patients Hospitalized With COVID-19 Pneumonia</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Drug: DILTIAZEM TEVA 60 mg or placebo<br/><b>Sponsors</b>: Hospices Civils de Lyon; Signia Therapeutics<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>VAX-MOM COVID-19: Increasing Maternal COVID-19 Vaccination</strong> - <b>Conditions</b>: Immunization; Infection; Pregnancy Related; COVID-19<br/><b>Interventions</b>: Behavioral: VAX-MOM COVID-19 Intervention; Other: Standard of Care<br/><b>Sponsors</b>: University of Rochester; Centers for Disease Control and Prevention; University of California, Los Angeles<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Simulation Education on Nursing Students</strong> - <b>Conditions</b>: COVID-19 Pandemic; Simulation of Physical Illness<br/><b>Interventions</b>: Behavioral: Simulation training; Other: Control Group<br/><b>Sponsor</b>: Mehmet Akif Ersoy University<br/><b>Completed</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Booster Dose Reminder/Recall for Adolescents</strong> - <b>Condition</b>: COVID-19 Vaccines<br/><b>Intervention</b>: Behavioral: Reminder/Recall Sent Via Preferred Method of Communication<br/><b>Sponsor</b>: Marshfield Clinic Research Foundation<br/><b>Active, not recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of AdCLD-CoV19-1 OMI as a Booster: A SARS-CoV-2 (COVID-19) Preventive Vaccine</strong> - <b>Conditions</b>: COVID-19; Vaccines<br/><b>Interventions</b>: Biological: AdCLD-CoV19-1 OMI (Part A); Biological: AdCLD-CoV19-1 OMI (Part B); Other: Placebo (Part B)<br/><b>Sponsor</b>: Cellid Co., Ltd.<br/><b>Active, not recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Different Masks Used by Pregnant Women on Vital Signs and Non Stress Test During The COVID-19</strong> - <b>Conditions</b>: Covid-19; Pregnant; Fetus; Mask<br/><b>Intervention</b>: Behavioral: Single surgical mask group, Double surgical mask group, N95 mask group<br/><b>Sponsor</b>: Bozok University<br/><b>Completed</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Personalized Computerized Training Program for Cognitive Dysfunction After COVID-19</strong> - <b>Conditions</b>: Post-Acute COVID-19; Long COVID<br/><b>Intervention</b>: Device: CogniFit’s CCT Post COVID-19<br/><b>Sponsor</b>: Universidad Antonio de Nebrija<br/><b>Completed</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Understanding the Impact of Death Conditions Linked to the COVID-19 Crisis on the Grieving Process in Bereaved Families</strong> - <b>Condition</b>: Psychological Disorder<br/><b>Intervention</b>: Other: Qualitative research interview<br/><b>Sponsor</b>: Assistance Publique - Hôpitaux de Paris<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) in People With Post Covid-19 Condition.</strong> - <b>Conditions</b>: Emotional Disorder; Post COVID-19 Condition; Anxiety Disorders; Depressive Disorder<br/><b>Intervention</b>: Behavioral: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders<br/><b>Sponsor</b>: Instituto de Investigación Sanitaria Aragón<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sequential Enhanced Safety Study of a Novel Coronavirus Messenger RNA (mRNA) Vaccine in Adults Aged 18 Years and Older.</strong> - <b>Condition</b>: Corona Virus Disease 2019(COVID-19)<br/><b>Intervention</b>: Biological: 0.3ml of mRNA vaccine<br/><b>Sponsor</b>: Yu Qin<br/><b>Enrolling by invitation</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impact of Teeth Brushing in Ventilated COVID-19 Patients.</strong> - <b>Conditions</b>: Microbial Colonization; COVID-19 Respiratory Infection; Dysbiosis; VAP - Ventilator Associated Pneumonia; HAI<br/><b>Intervention</b>: Procedure: Oral Procedure<br/><b>Sponsor</b>: University Hospital in Krakow<br/><b>Completed</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Physiology of Long COVID and the Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity</strong> - <b>Condition</b>: Post-acute Sequelae of SARS-CoV-2 Infection<br/><b>Intervention</b>: Behavioral: Exercise<br/><b>Sponsor</b>: University of Colorado, Denver<br/><b>Not yet recruiting</b></p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Developing PI3K Inhibitors for Respiratory Diseases</strong> - A number of different experimental models using both non-selective and selective PI3K inhibitors have shown that many pathogenic steps of respiratory disorders, such as bronchial asthma, Chronic Obstructive Pulmonary Disease (COPD), Idiopathic Pulmonary Fibrosis (IPF), Acute Respiratory Distress Syndrome (ARDS) and Lung Cancer (LC) are, at least in part, regulated by the PI3K signaling pathway, suggesting that the inhibition of PI3K could represent an ideal therapeutic target for the treatment…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glucocorticoids and COVID-19</strong> - Coronavirus Disease 19 (COVID-19) is associated with high morbidity and mortality rates globally, representing the greatest health and economic challenge today. Several drugs are currently approved for the treatment of COVID-19. Among these, glucocorticoids (GCs) have received particular attention due to their anti-inflammatory and immunosuppressive effects. In fact, GC are widely used in current clinical practice to treat inflammatory, allergic and autoimmune diseases. Major mechanisms of GC…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Thrombopoietin participates in platelet activation in COVID-19 patients</strong> - BACKGROUND: The pathogenesis of coronavirus disease 2019 (COVID-19) is characterized by enhanced platelet activation and diffuse hemostatic alterations, which may contribute to immunothrombosis/thromboinflammation and subsequent development of target-organ damage. Thrombopoietin (THPO), a growth factor essential to megakariocyte proliferation, is known to prime platelet activation and leukocyte-platelet interaction. In addition, THPO concentrations increase in several critical diseases, such as…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bioactive compounds of Jingfang Granules against SARS-CoV-2 virus proteases 3CL<sup>pro</sup> and PL<sup>pro</sup></strong> - CONCLUSION: Prim-O-glucosylcimifugin, neohesperidin, and naringin as the major compounds from Jingfang Granules could inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus proteases 3CL^(pro) and PL^(pro). The results are valuable for rational clinical use of Jingfang Granules.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synergistic action of organophosphates and COVID-19 on inflammation, oxidative stress, and renin-angiotensin system can amplify the risk of cardiovascular maladies</strong> - Organophosphates (OPs) are ubiquitous environmental contaminants, widely used as pesticides in agricultural fields. In addition, they serve as flame-retardants, plasticizers, antifoaming or antiwear agents in lacquers, hydraulic fluids, and floor polishing agents. Therefore, world-wide and massive applications of these compounds have increased the risk of unintentional exposure to non-targets including the human beings. OPs are neurotoxic agents as they inhibit the activity of acetylcholine…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immune-Related Adverse Events Among COVID-19-Vaccinated Patients With Cancer Receiving Immune Checkpoint Blockade</strong> - CONCLUSIONS: These findings should reassure providers that COVID-19 vaccination during ICI therapy is safe and efficacious.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational molecular interaction between SARS-CoV-2 main protease and theaflavin digallate using free energy perturbation and molecular dynamics</strong> - Our objective was to identify the molecule which can inhibit SARS-CoV-2 main protease and can be easily procured. Natural products may provide such molecules and can supplement the current custom chemical synthesis-based drug discovery for this objective. A combination of docking approaches, scoring functions, classical molecular dynamic simulation, binding pose metadynamics, and free energy perturbation calculations have been employed in this study. Theaflavin digallate has been observed in…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Acriflavine and proflavine hemisulfate as potential antivirals by targeting M<sup>pro</sup></strong> - The evolving SARS-CoV-2 epidemic buffets the world, and the concerted efforts are needed to explore effective drugs. M^(pro) is an intriguing antiviral target for interfering with viral RNA replication and transcription. In order to get potential anti-SARS-CoV-2 agents, we established an enzymatic assay using a fluorogenic substrate to screen the inhibitors of M^(pro). Fortunately, Acriflavine (ACF) and Proflavine Hemisulfate (PRF) with the same acridine scaffold were picked out for their good…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intradermal Testing With COVID-19 mRNA Vaccines Predicts Tolerance</strong> - CONCLUSION: Sensitization to SARS-CoV-2 mRNA vaccines can be detected with intradermal testing. Significantly more individuals were sensitized to mRNA vaccines in the post-vaccination cohort. A two-step 10-90%-vaccination protocol can be safely administered upon negative skin testing.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution</strong> - The genome of SARS-CoV-2 encodes for a helicase called nsp13 that is essential for viral replication and highly conserved across related viruses, making it an attractive antiviral target. Here we use nanopore tweezers, a high-resolution single-molecule technique, to gain detailed insight into how nsp13 turns ATP-hydrolysis into directed motion along nucleic acid strands. We measured nsp13 both as it translocates along single-stranded DNA or unwinds short DNA duplexes. Our data confirm that nsp13…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prophylactic treatment of <em>Glycyrrhiza glabra</em> mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis</strong> - Severe coronavirus disease (COVID-19) is accompanied by acute respiratory distress syndrome and pulmonary pathology, and is presented mostly with an inflammatory cytokine release, a dysregulated immune response, a skewed neutrophil/lymphocyte ratio, and a hypercoagulable state. Though vaccinations have proved effective in reducing the COVID-19-related mortality, the limitation of the use of vaccine against immunocompromised individuals, those with comorbidity, and emerging variants remains a…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signaling</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has becoming globally public health threat. Recently studies were focus on SARS-CoV-2 RNA to design vaccine and drugs. It was demonstrated that virus RNA could play as sponge to host noncoding RNAs to regulate cellular processes. Bioinformatic research predicted a series of motif on SARS-CoV-2 genome where are targets of human miRNAs. In this study, we used dual-luciferase reporter assays to validate the interaction between 3’UTR of…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synthesis and Evaluation of a Silver Nanoparticle/Polyurethane Composite That Exhibits Antiviral Activity against SARS-CoV-2</strong> - In this proof-of-concept study, we aim to produce a polyurethane (PU)-based composite that can reduce the amount of viable SARS-CoV-2 virus in contact with the surface of the polymeric film without further interventions such as manual cleaning. Current protocols for maintaining the hygiene of commonly used touchpoints (door handles, light switches, shop counters) typically rely on repeated washing with antimicrobial products. Since the start of the SARS-CoV-2 pandemic, frequent and costly…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antibacterial, Antifungal and Antiviral Polymeric Food Packaging in Post-COVID-19 Era</strong> - Consumers are now more concerned about food safety and hygiene following the COVID-19 pandemic. Antimicrobial packaging has attracted increased interest by reducing contamination of food surfaces to deliver quality and safe food while maintaining shelf life. Active packaging materials to reduce contamination or inhibit viral activity in packaged foods and on packaging surfaces are mostly prepared using solvent casting, but very few materials demonstrate antiviral activity on foods of animal…</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mulberrofuran G, a Mulberry Component, Prevents SARS-CoV-2 Infection by Blocking the Interaction between SARS-CoV-2 Spike Protein S1 Receptor-Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor</strong> - Despite the recent development of RNA replication-targeted COVID-19 drugs by global pharmaceutical companies, their prescription in clinical practice is limited by certain factors, including drug interaction, reproductive toxicity, and drug resistance. COVID-19 drugs with multiple targets for the SARS-CoV-2 life cycle may lead to a successful reduction in drug resistance as well as enhanced therapeutic efficacy, and natural products are a potential source of molecules with therapeutic effects…</p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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