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<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-new-yorker">From New Yorker</a></li>
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<li><a href="#from-vox">From Vox</a></li>
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<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
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<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
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<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
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<li><a href="#from-ars-technica">From Ars Technica</a></li>
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<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
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</ul>
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<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
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<ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The New COVID-19 Relief Package Is Flawed but Essential</strong> - If Congress had done nothing, the U.S. would soon face a humanitarian disaster as well as an economic one. - <a href="https://www.newyorker.com/news/our-columnists/the-new-covid-19-relief-package-is-flawed-but-essential">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What the Era of Trump and the Coronavirus May Teach America’s Children</strong> - The myths of national nobility do not exist for today’s first graders. - <a href="https://www.newyorker.com/news/daily-comment/what-the-era-of-trump-and-the-coronavirus-may-teach-americas-children">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Ammon Bundy Helped Foment an Anti-Masker Rebellion in Idaho</strong> - The COVID-19 pandemic has pitted establishment Republicans, who defer to public-health officials’ expertise, against hard-right libertarians. - <a href="https://www.newyorker.com/news/us-journal/how-ammon-bundy-helped-foment-an-anti-masker-rebellion-in-idaho">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Georgia Trump Fans Say the Last Election Was a Sham. Will They Vote in This One?</strong> - Kelly Loeffler and David Perdue are trying to placate the President and run for the Senate at the same time. - <a href="https://www.newyorker.com/news/us-journal/georgia-trump-fans-say-the-2020-election-was-a-sham-will-they-vote-in-this-one">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>As the Vaccine Arrives, Death and Denial Rage in a California Coronavirus Epicenter</strong> - In the San Joaquin Valley, medical professionals fear that many in the public still fail to grasp the dangers of COVID-19. - <a href="https://www.newyorker.com/science/medical-dispatch/as-the-vaccine-arrives-death-and-denial-rage-in-a-california-coronavirus-epicenter">link</a></p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
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<ul>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The viral tweet about Trump refusing to give Biden his <span class="citation">@POTUS</span> followers is wrong, even if it is on-brand</strong> -
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<figure>
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/ag6_ZZDPBYBvyZDWL-ZyGsniRQc=/541x0:5490x3712/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68569755/GettyImages_1215876854.0.jpg"/>
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<figcaption>
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President Trump speaks before signing an executive order targeting social media platforms for perceived anti-conservative bias. | Brendan Smialowski/AFP via Getty Images
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</figcaption>
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</figure></li>
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</ul>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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The confusion over what happens to Trump’s official White House Twitter accounts, briefly explained.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hAhZ6b">
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When Joe Biden becomes president on January 20, his administration will gain control of the <a href="https://twitter.com/potus"><span class="citation">@POTUS</span></a> and <a href="https://twitter.com/whitehouse"><span class="citation">@WhiteHouse</span></a> Twitter accounts. But the combined 60 million followers of those accounts may not be going with them.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Qw48Rx">
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The transfer has become an issue between Twitter and the Biden transition team, according to <a href="https://www.wsj.com/articles/trump-will-face-different-twitter-rules-when-he-leaves-office-11608642198">the Wall Street Journal</a>. The Biden team wants to keep the followers of those accounts, as was the case for the Obama-Trump transition. Four years ago, and dealing with this issue for the first time, the Obama administration <a href="https://obamawhitehouse.archives.gov/blog/2016/10/31/digital-transition-how-presidential-transition-works-social-media-age">made it a point</a> to make the digital transition as smooth and seamless as possible. This time, Twitter has other ideas.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PzJ81V">
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“The accounts will not automatically retain their existing followers,” Twitter spokesperson Nick Pacilio said in a statement. “Instead, Twitter will notify followers of these accounts to provide context that the content will be archived and allow them the choice to follow the Biden administration’s new accounts.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0AdmSM">
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Twitter did not provide a reason for the change, but the Wall Street Journal article pointed out that the 2017 Twitter transition had <a href="https://www.cnbc.com/2017/01/21/twitter-unwittingly-forces-users-to-follow-potus-account-after-transition-from-obama-to-trump.html">technical issues</a>. Among them, a glitch caused people who had deliberately unfollowed the <span class="citation">@POTUS</span> account to automatically follow it again, which many people did not appreciate.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rBHWOc">
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What might have been a minor issue blew up on — where else? — Twitter on Tuesday afternoon after a freelance journalist named Hugo Lowell tweeted that the Trump administration refused to give its followers to Biden.
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</p>
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<div id="zz8RiV">
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<blockquote class="twitter-tweet">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
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Biden transition says Trump admin has refused to transfer the <a href="https://twitter.com/POTUS?ref_src=twsrc%5Etfw"><span class="citation">@POTUS</span></a> and <a href="https://twitter.com/WhiteHouse?ref_src=twsrc%5Etfw"><span class="citation">@WhiteHouse</span></a> Twitter accounts with followers and that Biden must start from zero — reversing goodwill gesture from Obama admin in 2016.
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</p>
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— Hugo Lowell (<span class="citation">@hugolowell</span>) <a href="https://twitter.com/hugolowell/status/1341432767888957442?ref_src=twsrc%5Etfw">December 22, 2020</a>
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</blockquote>
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</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="49njt5">
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But that’s not true, according to Twitter, which said it was an “inaccurate characterization.” Biden digital director Rob Flaherty agreed.
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</p>
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<div id="6SXQUn">
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<blockquote class="twitter-tweet">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
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Just to be clear: this is Twitter's decision, not Trump's.<a href="https://t.co/7jqhLmbX9e">https://t.co/7jqhLmbX9e</a>
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</p>
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— Rob Flaherty (<span class="citation">@Rob_Flaherty</span>) <a href="https://twitter.com/Rob_Flaherty/status/1341481779899842561?ref_src=twsrc%5Etfw">December 22, 2020</a>
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</blockquote>
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</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tqdU0I">
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The White House did not respond to a request for comment.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FUnF1N">
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Lowell declined to comment, but he did issue a correction.
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</p>
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<div id="ew95DP">
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<blockquote class="twitter-tweet">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
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Correction: Digital Director for Joe Biden <a href="https://twitter.com/Rob_Flaherty?ref_src=twsrc%5Etfw"><span class="citation">@Rob_Flaherty</span></a> says <a href="https://twitter.com/POTUS?ref_src=twsrc%5Etfw"><span class="citation">@POTUS</span></a> and <a href="https://twitter.com/WhiteHouse?ref_src=twsrc%5Etfw"><span class="citation">@WhiteHouse</span></a> accounts being reset to zero followers is Twitter’s decision, not the Trump admin. Unclear still whether Trump admin has asked for followers to roll over as Obama did in 2016. <a href="https://t.co/T659ZZgC89">https://t.co/T659ZZgC89</a>
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</p>
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— Hugo Lowell (<span class="citation">@hugolowell</span>) <a href="https://twitter.com/hugolowell/status/1341530333074874370?ref_src=twsrc%5Etfw">December 22, 2020</a>
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</blockquote>
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</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EwrFtU">
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Lowell’s incorrect tweet has gotten thousands of retweets and “Likes,” and understandably so: It is consistent with Trump’s brand to do something like this. Trump is <a href="https://www.rollingstone.com/politics/politics-news/trump-twitter-followers-obama-826471/">obsessed</a> with how many followers he has and with having more of them than anyone else, so it would make sense if he were loath to give away the tens of millions of followers acquired during his presidency to the person who beat him.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="skut04">
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Such pettiness would have also been a fitting end to the <a href="https://www.vox.com/the-highlight/22170168/trump-twitter-social-media-presidency-aoc-biden">Twitter presidency</a>. Twitter helped Trump get elected, as he used the platform to raise his profile, speak out against Obama, and spread racist birther conspiracies. The platform also enabled Trump to run a successful presidential campaign, run the country, and, finally, run an unsuccessful presidential campaign — all without changing his behavior or tone one bit.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sLXWbv">
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It’s therefore ironic that Trump would be the victim of viral misinformation-by-tweet after being <a href="https://www.nytimes.com/2020/11/23/technology/election-misinformation-facebook-twitter.html">a misinformation superspreader</a> himself. He has lied, frequently, and then watched those lies spread across social media before making their way onto traditional media formats to be seen and heard by millions if not billions.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u0maKp">
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President Trump has faced few consequences for his tweets. <a href="https://www.vox.com/recode/2020/5/26/21271210/twitter-fact-check-trump-tweets-mail-voting-fraud-rigged-election-misleading-statements">Only in the last year</a>, when it became apparent that there was a real chance he would lose the election, did social media platforms try to curb the misinformation he expertly used them to spread. It will be interesting to see how they treat him once his account isn’t subject to special rules for public officials; Twitter has already said it would consider taking down Trump tweets that violate its rules (currently, it only tags them with a fact-check). When he leaves office in January, Trump will still have control over his personal account, <span class="citation">@realDonaldTrump</span>, which he used far more than the official accounts and which has millions more followers than <span class="citation">@POTUS</span> and <span class="citation">@WhiteHouse</span> combined.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZkawAr">
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So after all that, maybe it’s for the best that the official White House accounts get a fresh start and a chance to rebuild from the ground up. Hopefully, the people who followed those accounts purely out of interest in and respect for the offices — as opposed to whoever happens to be in them — will see and accept the offer to follow them again.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mvsPe3">
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<strong>Update, December 22, 7 pm ET:</strong> Added Hugo Lowell’s correction tweet and decline to comment.
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</p>
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<ul>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The political chief at Mark Zuckerberg’s philanthropy is stepping down</strong> -
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<figure>
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<img alt="Priscilla Chan and Mark Zuckerberg speak with another person in front of a sign reading, “Chan Zuckerberg Initiative.”" src="https://cdn.vox-cdn.com/thumbor/VkWZAmCEdQT6hZpykFdKmmlovxM=/0x136:5185x4025/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68569573/1MP_CZI.0.jpg"/>
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<figcaption>
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Courtesy of The Chan Zuckerberg Initiative
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</figcaption>
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</figure></li>
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</ul>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Mike Troncoso is a former top aide to Kamala Harris, so this move is stirring speculation about a move to the White House.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pwcoX9">
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The political chief of Mark Zuckerberg’s philanthropy is leaving his post, Recode has learned, which is stirring some speculation that he could take on a new role with his former boss, Kamala Harris.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BXU8CA">
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Mike Troncoso, once a top aide to Harris, is stepping down from his position as the head of the Chan Zuckerberg Initiative’s Justice and Opportunity Initiatives (JOI), CZI confirmed to Recode. The leader of JOI is one of the top positions at the organization that Zuckerberg and his wife, Priscilla Chan, founded in 2015. As the head of JOI, Troncoso oversaw one of Silicon Valley’s biggest political advocacy operations that has spent hundreds of millions of dollars pushing for immigration reform, changes to the criminal justice system, and more affordable housing.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Khq1aU">
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The departure is notable for two reasons: Zuckerberg’s political team at his philanthropy has had to <a href="https://www.vox.com/recode/2020/6/26/21303664/mark-zuckerberg-facebook-chan-zuckerberg-initiative-philanthropy-tension">navigate tricky tensions</a> that are rooted in political challenges in Zuckerberg’s day job at Facebook, challenges that will only intensify under Joe Biden. And secondly, the timing of Troncoso’s departure raises the possibility that he could be in line for a senior position staffing with Harris, which would serve as another possible link between the Biden administration and Zuckerberg, who is facing antitrust scrutiny and a skeptical public.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sD32Ai">
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Troncoso served as chief counsel to Harris when she was California’s attorney general. He <a href="https://www.theatlantic.com/politics/archive/2020/08/kamala-harris-biden-mortgage-settlement/615394/">oversaw a major investigation</a> into the state’s banking actions during the financial crisis, one of her landmark accomplishments, and he later co-chaired her transition team when she was elected to the Senate. Harris name-checks Troncoso in her autobiography’s acknowledgments.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TTss6u">
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Troncoso had recently told people he works with at CZI that he did not currently have plans to join the administration, according to sources, but that no decision had been made. CZI said that Troncoso planned to return to public service and is relocating with his family to the East Coast.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CkR6JO">
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Harris has only unveiled the names of a few of her top aides. The Biden-Harris transition team didn’t return a request for comment.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7ovCSh">
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Troncoso <a href="https://www.bloomberg.com/news/articles/2019-10-10/david-plouffe-moves-to-part-time-role-at-zuckerberg-philanthropy">succeeded David Plouffe</a>, Barack Obama’s longtime political adviser, in the role overseeing CZI’s JOI programming. While Troncoso was a lower-profile figure, he oversaw a number of high-profile political projects, such as the <a href="https://www.vox.com/recode/21508914/mark-zuckerberg-priscilla-chan-proposition-13-split-roll-california-politics">$10 million</a> that CZI spent on its ultimately unsuccessful attempt to add billions to California’s budget, CZI’s most expensive electoral play yet. Troncoso originally oversaw CZI’s work on criminal justice reform, and CZI eventually was <a href="https://www.facebook.com/zuck/posts/10111969612272851">spending about $40 million a year</a> on that effort, becoming one of the area’s largest philanthropic funders.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9dq3PU">
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He had to navigate making these plays at a time when CZI’s co-founder, Zuckerberg, and the source of its wealth, Facebook, grew to become a greater liability. <a href="https://www.vox.com/recode/2020/6/26/21303664/mark-zuckerberg-facebook-chan-zuckerberg-initiative-philanthropy-tension">Some of that antagonism has ricocheted onto Zuckerberg’s philanthropy,</a> even though CZI is entirely distinct from Facebook. Some people who have worked at CZI have alleged that its political work is overly sensitive to what could impact Facebook, and a former JOI employee last month publicly <a href="https://rayholgado.medium.com/chan-zuckerberg-initiative-racial-discrimination-claim-4d4637f054d8">filed a discrimination complaint</a> against the organization, claiming in part that Troncoso’s team did not center racial equity enough in its political programming. <a href="https://www.theverge.com/2020/11/10/21559126/chan-zuckerberg-initiative-raymond-holgado-racial-discrimination-complaint">CZI has said</a> that it investigated these claims and they are “unsubstantiated.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="spnGLU">
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Troncoso will be succeeded at least in the interim by Osi Imeokparia, who comes from a more technical background and oversaw the JOI team’s product development.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JeFArh">
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Like other political advocacy shops, CZI will probably have to rethink some of its programming under a new president and in a new political climate, especially its work on federal immigration reform. CZI recently <a href="https://chanzuckerberg.com/about/annual-letter/year-2020/">released an internal report card of sorts</a> on its five-year anniversary this month, which disclosed that it had spent $436 million on its JOI work during that time.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RNBqhy">
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As part of that review, CZI also said it would spend $500 million over the next five years on initiatives focused on racial equity, something that Zuckerberg critics <a href="https://www.vox.com/recode/2020/6/1/21277108/facebook-employees-protest-mark-zuckerberg-trump-looting-shooting-george-floyd-fact-check">say he has fumbled at Facebook</a>.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="11rUqX">
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</p>
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<ul>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The new UK coronavirus mutations, explained</strong> -
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<figure>
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/z4hiXUP3U9Km0646GDsqupBy98M=/260x0:1820x1170/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68569350/Covid_UK.0.jpg"/>
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<figcaption>
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Illustration by Zac Freeland/Vox
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</figcaption>
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</figure></li>
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</ul>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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What scientists have learned about the Covid-19 variants in the UK, South Africa, and other parts of the world.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7E5mgC">
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Health officials in the United Kingdom and around the world are worried about a new, seemingly more contagious variety of SARS-CoV-2 (the virus that causes <a href="https://www.vox.com/coronavirus-covid19">Covid-19</a>), which has emerged in the country and was announced over the weekend. The evidence that this new strain spreads more easily between people is not rock solid, but it’s concerning enough to have forced dramatic action.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e3OSDv">
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Nations are already shutting down travel <a href="https://www.npr.org/sections/coronavirus-live-updates/2020/12/21/948751745/travel-from-the-u-k-shut-down-as-nations-assess-threat-of-new-coronavirus-strain">from the United Kingdom</a>, where the new strain, known as B.1.1.7 (we’ll call it the UK variant, for simplicity’s sake), is rapidly spreading in the southeastern part of the country. Within the UK, officials are imposing <a href="https://abcnews.go.com/International/coronavirus-variant-uk-prompts-lockdown-travel-bans-evidence/story?id=74842248">stricter limits on movement and public spaces</a>.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2QC8m1">
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Right now it doesn’t appear as though the new UK variant of SARS-CoV-2 is more dangerous in individuals. It doesn’t seem to make people sicker, nor is it more likely to kill them. “I think the key point is that there is no evidence now … that this virus is more pathogenic — creates more problems, more morbidity and mortality — than the previous virus,” <a href="https://www.hhs.gov/about/news/2020/05/15/trump-administration-announces-framework-and-leadership-for-operation-warp-speed.html">Moncef Slaoui</a>, the scientific lead for Operation Warp Speed, said during a Monday <a href="https://www.youtube.com/watch?v=5G8uPGyDjic">press conference</a>.
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||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UQZE1g">
|
||
What it does appear to do, at least based on preliminary evidence, is spread more quickly among people. That alone is a problem: The coronavirus spreads fast enough as it is. Compounding concerns is that the UK variant echoes a similar story in <a href="https://apnews.com/article/new-coronavirus-strain-south-africa-31a0d5840a17fa5c82f2ecd14ba9921b">South Africa</a>, where a strain called 501.V2 has become the dominant version among new cases of the virus. Scientists are wondering whether that strain is more transmissible, too.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xH22Yl">
|
||
The virus has been continually changing its genetics through the course of the pandemic. That’s what RNA-based viruses like SARS-CoV-2 do — they mutate. Most of the time, the mutations mean nothing. But this time, something is different.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FV0paB">
|
||
“I’ve spent a lot of time this year reminding people that mutations are normal,” molecular epidemiologist <a href="http://emmahodcroft.com/">Emma Hodcroft</a>, who works on a project called <a href="https://nextstrain.org/">Nextstrain</a>, said. For the entire pandemic, scientists the world over have been feeding Nextstrain sequences of the virus, and Hodcroft and her colleagues have been tracking its genetic changes closely.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uimlqr">
|
||
In the past, mutations haven’t warranted big newspaper headlines. “I’m now finding myself singing a slightly different tune,” Hodcroft said. This time, there does seem to be evidence that the new strain is something worth being vigilant about. “We probably should consider taking some precautionary measures while we’re trying to find out more,” she added.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EF6z4U">
|
||
At the same time, Covid-19 is surging around the world, even without these new mutations. Scientists are still trying to figure out what these new variants of the coronavirus actually mean for the pandemic. It’s also unclear where else the UK variant may have already spread. “The variant could already be in the United States without having been detected,” the US Centers for Disease Control and Prevention <a href="https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html">reported</a> Tuesday.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3WdEPP">
|
||
The good news is that we already know how to respond to these new variants: in the same way we’ve been responding to the pandemic overall. The virus still transmits primarily through viral-laden breaths in the air. Mask-wearing, social distancing, and good indoor ventilation are as critical as ever.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eAp9uo">
|
||
There’s a lot about this story that’s potentially very alarming, or confusing. And the story is not yet complete, as scientists need more evidence to understand whether these new variants pose a new threat.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BGroeT">
|
||
To add some clarity, here’s what researchers have learned so far. Let’s start with the basics.
|
||
</p>
|
||
<h3 id="JqQobE">
|
||
Viral mutations, explained
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A4GeiD">
|
||
Viral mutations. New strains. Increased transmission. It all sounds like scary science fiction. But to demystify things, and to understand why scientists are a little concerned about this new variant — and why most variants don’t faze them — it’s worth understanding how viruses mutate in the first place.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OM33h7">
|
||
“Oftentimes, I think the word mutation in general conjures up a lot of things in people’s minds, like, you know, Ninja Turtles or X-Men or cancer, like zombie apocalypse-type stuff,” <a href="https://ghss.georgetown.edu/people/angela-rasmussen/">Angela Rasmussen</a>, a virologist with Georgetown’s Center for Global Health Science and Security, said. “A mutation is just a lot more mundane than that.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YBXhRm">
|
||
Viruses mutate because they’re constantly making copies of themselves in enormous numbers. To accomplish this, they have to hijack the hardware of a host cell that they infect. However, this process can be a bit sloppy.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1wBIEt">
|
||
Within a human body, a virus can replicate itself millions or billions of times, Hodcroft explains. If you were writing a draft of something millions of times on a computer, extremely quickly, you’d probably make some typos. That’s what’s happening with the viruses. “They make a typo” in their genetic code, she says. One letter of their ribonucleic acid (RNA) chain is replaced with another.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0z91lN">
|
||
Viruses that use RNA as their genetic material, like SARS-CoV-2, are particularly vulnerable to mutations since the RNA molecule itself is more unstable than DNA. The process of copying RNA is also more prone to error.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MH9nOj">
|
||
These typos can be very useful for scientists because they happen at a regular rate, and are passed down through generations of the virus as it spreads through a community. Often, scientists can use these subtle changes to trace certain strains’ lineage and their spread through a population.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l0NhR9">
|
||
The majority of these typos are inconsequential when it comes to human health. “One typo, or even a few typos, doesn’t usually change how the virus works,” Hodcroft says. Some even harm the virus. “You’re much more likely to break it than to make it better” when it comes to mutations, she says.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HGkWRP">
|
||
But in rare instances, some mutations can give a virus an advantage, like allowing it to infect cells more readily or spread among people faster. Those mutant strains can then become dominant within a population.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hav0re">
|
||
That might be what we’re looking at here with the UK variant; this new strain may have accumulated typos that could make it more easily transmitted between people.
|
||
</p>
|
||
<h3 id="2dmw3O">
|
||
Four lines of evidence converging on this new mutation being more transmissible
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Y51zQ">
|
||
So why do scientists think this variant is more transmissible?
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Jct7w8">
|
||
They don’t have this nailed down yet for sure, but four converging streams of evidence are all pointing in the same direction. “That’s making people feel like maybe there is something here to be worried about,” Hodcroft says. “Each one of these things on their own, I would say is not necessarily convincing.” But all together, they paint a concerning picture.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HpnQaU">
|
||
One is that in the areas of the UK where this new variant is spreading, it is accounting for a larger proportion of new cases. “What this implies is that this new variant is spreading better than other variants that are circulating in the same region,” she says.
|
||
</p>
|
||
<div id="uHkWsG">
|
||
<blockquote class="twitter-tweet">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
|
||
National testing data shows increased prevalence of the variant in positive cases over time. This is detected incidentally by the commonly used 3-gene PCR test because 69-70del leads to a negative signal. But this does not effect the results of the test. 7/<br/>h/t <a href="https://twitter.com/The_Soup_Dragon?ref_src=twsrc%5Etfw"><span class="citation">@The_Soup_Dragon</span></a> <a href="https://t.co/aPpAjjb35W">pic.twitter.com/aPpAjjb35W</a>
|
||
</p>
|
||
— Muge Cevik (<span class="citation">@mugecevik</span>) <a href="https://twitter.com/mugecevik/status/1341094871822680067?ref_src=twsrc%5Etfw">December 21, 2020</a>
|
||
</blockquote>
|
||
</div>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aY09i5">
|
||
A second is that the increase didn’t co-occur with any overly obvious change in human behavior. “We don’t really have strong evidence that everyone in the southeast [UK where this variant is spreading] has just ripped their masks off and is, you know, totally violating restrictions,” she says. That said, it could be a coincidence. It could be just that people who happen to have contracted this variant have it are spreading it more often via their behavior.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PqgUXB">
|
||
After all, “this new variant has emerged at a time of the year when there has traditionally been increased family and social mixing,” according to the <a href="https://www.ecdc.europa.eu/en/publications-data/threat-assessment-brief-rapid-increase-sars-cov-2-variant-united-kingdom">European Center for Disease Prevention and Control</a>, which estimated that the transmissibility of the new variant has increased by 70 percent compared to prior versions of the virus. (Both Rasmussen and Hodcroft say the 70 percent more transmissible figure is most likely an overestimate.)
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1zJydD">
|
||
Third, there’s some early data about how this variant acts in Covid-19 patients. “There may be slightly higher viral loads in patients with the variants,” Hodcroft says, suggesting the virus has an easier time replicating in the body. (Viral load refers to the amount of virus in the patient. Rasmussen also cautions that viral load data is really sensitive to timing and when the patient was sampled in the course of the illness, so there needs to be more data to confirm this.)
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="noaKCM">
|
||
Finally, the genetic changes in the UK variant mirror changes in the South African variant, which has also been associated with rising case numbers. That makes a plausible link: that this particular genetic change may be behind the increased transmissibility in both variants.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JtWl8E">
|
||
However, this is still short of definitive confirmation that the new variant is more transmissible.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jEAEmP">
|
||
According to Slaoui, figuring this out for certain would require laboratory animal testing to see how easily the virus can spread from one organism to another. But this testing can take several weeks.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OEUlSn">
|
||
In the face of that uncertainty, many urge caution.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VVoYm6">
|
||
Again, there’s still no evidence this new variant causes more severe disease. The evidence only points to increased transmissibility. But a more transmissible virus is still a concern. “In general, the more people get infected, the number of hospitalizations and deaths rise accordingly as a proportion of that number,” Hodcroft says. “So more cases is also bad news.”
|
||
</p>
|
||
<h3 id="TG5rcr">
|
||
What does the mutation ... do?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5q1EBv">
|
||
The UK variant of SARS-CoV-2 actually contains 23 mutations in the genome of the virus. “We don’t really know what they do,” Rasmussen says. Individually, many of these mutations have already been seen in other strains of the virus around the world. But the combination of these changes in a single virus could be making the new variant more likely to spread.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gdDdxa">
|
||
However, scientists do think that some mutations may be more important than others, and there are several mechanisms by which mutations could make the virus more infectious. Those include:
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZtKOm3">
|
||
</p><ol style="list-style-type: decimal">
|
||
<li>The virus could end up with changes to its spike protein that allow it to enter cells more easily.
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g29Sx5">
|
||
</p><ol start="2" style="list-style-type: decimal">
|
||
<li>The virus could develop a mechanism to replicate more quickly inside a body, which would lead “to people becoming infectious faster, or contagious faster than they would with another variant,” Rasmussen explains.
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hXzAKl">
|
||
</p><ol start="3" style="list-style-type: decimal">
|
||
<li>The virus could theoretically have evolved an ability to counteract the cell’s innate immune defenses, making it easier to infect that cell.
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NCa9u7">
|
||
One of the pathways scientists suspect may be at work stems from the N501Y mutation, where the amino acid asparagine is replaced by the amino acid tyrosine in the 501st position of the viral protein sequence. It’s one of several mutations in the virus’s spike protein in the UK variant, but N501Y is in the part of the spike that actually comes into direct contact with human cells. The same mutation has been found in the South African variant of SARS-CoV-2 that’s also quickly spreading.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nNs6Ei">
|
||
Since the virus attaching to a host cell is critical to the virus’s reproduction, the virus’s spike protein is especially important — and delicate.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F6Wo93">
|
||
“If you were just making random changes in the lab, almost any change you make in that area would result in just a dead virus that can no longer get into the cell,” said <a href="https://tamut.edu/academics/Colleges-and-Departments/CASE/Undergraduate-Programs/Biology/bneumanCV.pdf">Benjamin Neuman,</a> a virologist at Texas A&M University Texarkana. “That fact that this thing is able to spread at all tells you that it’s at least as good as the original version. The fact that it’s spreading faster may indicate that it’s a little bit better at grabbing on to host cells, which is the first step of the entry process.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5jxoC7">
|
||
But this particular N501Y mutation has already been detected in strains that have risen and fallen in other parts of the world over the course of the pandemic. So it may be that the other mutations coupled with N501Y are having some sort of compounding effect. And scientists still need to do more work to determine if this is actually what’s causing the rise of the new SARS-CoV-2 variant in the UK. Finding out the answer could help researchers come up with ways to counter this variety of the coronavirus.
|
||
</p>
|
||
<h3 id="PfqUji">
|
||
How did these coronavirus mutations happen?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cptkXt">
|
||
Scientists don’t know exactly how the UK variant came to be. But there may be a clue. Hodcraft is struck by the sheer number of mutations in the UK variant — 23 in all — which makes her suspect it’s possible this variant arose in an immunocompromised person. “It’s an above-average number of mutations,” she says.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NqsUNm">
|
||
In most people, she explains, the immune system mounts a full-on assault on the virus, eliminating it in a matter of a couple of weeks. “In people that have compromised immune systems, though, there’s a very different dynamic,” she says. “So, for one thing, the virus could be in them for months instead of weeks.” That gives the virus more time to evolve, to accumulate mutations that might make it easier to thwart the immune system.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FzgXMP">
|
||
“It’s one scenario,” she says. “We may never know exactly what happened here.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WEpDLh">
|
||
The basic truth: The more this virus spreads, the more chances there are for dangerous new variants to emerge. In any person — or <a href="https://www.vox.com/science-and-health/2020/12/16/21826130/coronavirus-covid-19-in-animals-mink-dog-cats-gorillas-tigers">animal, for that matter</a> — the chance for a dangerous new variant to arise is rare. But rare things can happen when there are so many cases: more than <a href="https://coronavirus.jhu.edu/map.html">77 million confirmed cases worldwide</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L2CjV5">
|
||
Since viruses like SARS-CoV-2 are mutating and since Covid-19 has spread in so many people, it’s theoretically only a matter of time before a certain set of mutations align in a way to give the virus a boost.
|
||
</p>
|
||
<h3 id="l7vml9">
|
||
What can we do about Covid-19 mutants?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ift3lH">
|
||
To stop mutations, quite simply, we need to stop the spread of SARS-CoV-2 in general. For one, that helps us deal with the pandemic overall. But “that’s also conveniently how we get fewer emerging variants,” Rasmussen says. “If the virus isn’t replicating, it can’t mutate. And if it can’t mutate, the new variants can’t emerge.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r3201F">
|
||
We fight the new variant as we would any variant of SARS-CoV-2: with masks, with social distancing, with good hand hygiene. “I don’t think people should be panicking,” Hodcroft says. “Lower case numbers, no matter what the variant, are better.”
|
||
</p>
|
||
<div id="dHLBFg">
|
||
<blockquote class="twitter-tweet">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
|
||
It’s already been said but if we actually follow protocol and have policies that support those protocols a new variant that is more transmissible would be combatted just as an older variant. So like worry less about mutants and more about masking and distancing and vaccination.
|
||
</p>
|
||
— K. Taylor, Ph.D., M.S. (<span class="citation">@KYT_ThatsME</span>) <a href="https://twitter.com/KYT_ThatsME/status/1340823722136104961?ref_src=twsrc%5Etfw">December 21, 2020</a>
|
||
</blockquote></div></li>
|
||
</ol></li>
|
||
</ol></li>
|
||
</ol>
|
||
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gFk3MS">
|
||
Scientists have one more tool, though: genetic tracking. At Nextstrain, Hodcroft and her colleagues receive viral genetic sequences from all over the world to try to paint a real-time picture of transmission chains and keep tabs on how the virus is changing. But not every place in the world is providing the same amount of data.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="inHwvY">
|
||
The UK does a lot of viral sequencing, for instance. It was able to pick up on the new viral strain quickly because of that. In other locations around the globe, that might not have happened so fast.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="At2rFP">
|
||
“In the US, it’s a really spotty picture,” Hodcroft says when it comes to sequencing. “Some states have really invested in sequencing; some states haven’t. So for some states, we probably have a fair idea of what’s going on. In other states, we really don’t have many sequences.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gtSP21">
|
||
Overall, the CDC <a href="https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html">reports</a> that the US has only sequenced 51,000 of the 17 million cases reported here (that’s .07 percent. In comparison, the UK aims to sequence <a href="https://www.cogconsortium.uk/news_item/how-do-we-collect-and-sequence-sars-cov-2-samples/">10,000 virus <em>per week</em></a>, and plans to increase that capacity further). That lack of viral genetic testing creates a big blindspot. The UK variant could have already arrived here undetected “given the small fraction of US infections that have been sequenced,” the CDC <a href="https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html">states</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EqiasJ">
|
||
More sequencing, overall, would lead to the faster detection of new strains and faster means to contain them if they were deemed problematic.
|
||
</p>
|
||
<h3 id="ql7mht">
|
||
Do mutations mean a Covid-19 vaccine won’t work anymore?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WWvya2">
|
||
With new mutations, there is a concern that a new strain of SARS-CoV-2 could arise that would be different enough from previous versions such that prior exposures — whether through a vaccine or an infection — won’t offer protection. So, yes, it’s possible that the coronavirus could someday mutate in a way that would elude a vaccine or previous immunity.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hO8TOl">
|
||
Right now, though, scientists think this UK variant would still fall under the same umbrella of protection as earlier strains. If someone received a Covid-19 vaccine for an older generation of the virus, they would likely have protection against this one.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ugSSo9">
|
||
To explain why, it helps to understand how the immune system deals with viruses. When the human body detects a hostile foreign entity like a virus, it starts to produce antibodies (proteins that attach to the virus or to infected cells). Antibodies can then interfere with how the virus works. They can also flag the virus or virus-infected cells for destruction by other immune cells.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eSM0jG">
|
||
The specific places where the antibodies attach to the virus are called <a href="https://www.britannica.com/science/epitope">epitopes</a>, and most Covid-19 vaccines target epitopes on the virus’s spike protein (which is what the virus uses to attach to human cells and enter them).
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y5VF51">
|
||
“The good thing with the vaccine is that it induces an immune response against several epitopes that have been mapped around the spike protein,” Slaoui said. “The chances that one set of mutations would alter all those epitopes, I think, are extremely very low. The expectation, scientifically, is that these kinds of variations are unlikely to escape fully the protective response by the vaccine.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wLCNdm">
|
||
More good news: Scientists at the University of Texas Medical Branch have announced (<a href="https://twitter.com/TheMenacheryLab/status/1341460341293723650">via a tweet</a>) preliminary evidence that antibodies that neutralize the more common strain of the virus also neutralize a strain with the N501Y mutation (the one that impacts the part of the virus that comes into direct contact with human cells, as mentioned above). That suggests that an immune system primed — by a natural infection, at least — to fight the old variant can also fight one with this specific mutation.
|
||
</p>
|
||
<div id="MO9JSj">
|
||
<blockquote class="twitter-tweet">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
|
||
Some good news (and incredibly fast work) on one of the mutations scientists are worried about: N501Y.<br/>In these lab experiments serum from recovered <a href="https://twitter.com/hashtag/covid19?src=hash&ref_src=twsrc%5Etfw">#covid19</a> patients was just as good at neutralizing virus with the mutation as without it. <a href="https://t.co/SIxfo2x3qp">https://t.co/SIxfo2x3qp</a>
|
||
</p>
|
||
— Kai Kupferschmidt (<span class="citation">@kakape</span>) <a href="https://twitter.com/kakape/status/1341496927318388739?ref_src=twsrc%5Etfw">December 22, 2020</a>
|
||
</blockquote>
|
||
</div>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x22GKL">
|
||
Texas A&M’s Neuman noted that there’s also evidence right now showing how well vaccines can protect against mutated forms of the virus in clinical trials. Many of the vaccines being administered were engineered to counter the earliest generations of SARS-CoV-2 but are still showing themselves to be highly effective against Covid-19 caused by more recent versions of the virus.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XBfVdc">
|
||
“All the tests are being done, all the papers being published, are being done with current strains, which have several mutations relative to [the first iterations of the virus], and it does still seem to be working,” Neuman said.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sKE4P5">
|
||
Covid-19 vaccine developers say they are keeping a close eye on these changes and testing to make sure their vaccines are still effective. “In terms of the new variant, <a href="https://www.vox.com/22167841/fda-vaccine-approval-pfizer-biontech-covid-19-eua-coronavirus">Pfizer and BioNTech</a> are monitoring SARS-CoV-2 sequence changes and the companies are working to generate data on how well serum from people immunized with [the Pfizer/BioNTech vaccine] may be able to neutralize the new strain,” said a Pfizer spokesperson via email.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vRxui9">
|
||
And the new Covid-19 vaccines are well-equipped to adapt. The two that have received emergency use authorizations from the Food and Drug Administration — the Pfizer/BioNTech vaccine and the <a href="https://www.vox.com/2020/12/18/22188715/moderna-vaccine-covid-19-fda-emergency-use-authorization-coronavirus">Moderna vaccine</a> — both use <a href="https://www.vox.com/2020/8/13/21359025/coronavirus-vaccine-covid-19-moderna-oxford-mrna-adenovirus">mRNA as their platform</a>. These vaccines deliver the instructions for making the spike protein of SARS-CoV-2 to human cells. Those human cells then manufacture the component themselves, allowing the immune system to use it to prepare for an infection. One huge advantage of this approach is that the mRNA sequence can be altered quickly; the first such vaccines for Covid-19 were <a href="https://nymag.com/intelligencer/2020/12/moderna-covid-19-vaccine-design.html">developed within days</a> after the genetic sequence of the virus was posted online.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UyAQ8q">
|
||
Could manufacturers like Moderna or Pfizer/BioNTech then retool their vaccines to target the new variants without going through the whole tedious clinical trial process again?
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Pt4BOR">
|
||
Possibly, according to <a href="https://globalhealth.georgetown.edu/people/jesse-goodman">Jesse Goodman</a>, a former chief scientist at the FDA and a professor of medicine at Georgetown University. He told Vox that vaccines for new variants of the influenza virus are approved every year without large-scale trials. New versions of a Covid-19 vaccine to accommodate mutations similarly might not need another round of study in tens of thousands of people, but may require some testing to figure out dosing and immune response. With such a new virus and brand new vaccines, the regulations for these situations have not yet been laid out.
|
||
</p>
|
||
<h3 id="ELyZ9T">
|
||
Should we expect more mutations in the future?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tlkzXx">
|
||
Short answer: yes.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ArUqoF">
|
||
The UK and South African variants are unlikely to be the last to make headlines. Coronavirus is constantly evolving. We should expect it to keep changing slightly.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZEciZz">
|
||
“There will be new variants that emerge,” Rasmussen says. The thing is, with each new significant strain, scientists will have to do careful work to determine whether it’s more dangerous.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uLanYV">
|
||
And there are some mutations we can perhaps even expect — if not in the coming weeks, over the next several years.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pdUaUb">
|
||
Recently, virology researchers at the Fred Hutch Cancer Research Center published a <a href="https://www.biorxiv.org/content/10.1101/2020.12.17.423313v1">preprint</a> (i.e., not yet peer-reviewed) study, looking at how a coronavirus that causes the common cold evolved from the 1980s onward. To accomplish that, they got old blood samples, which included antibodies that cling to this particular virus. They also reconstructed pieces of the cold virus from other eras. Basically, they wanted to see if older blood could still neutralize newer virus. If it couldn’t, that would indicate the virus has evolved over time to evade the immune system.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KBGZ3A">
|
||
Here’s what the researchers found: “This other human coronavirus does indeed evolve over the course of multiple years to gradually escape human immunity,” <a href="https://www.fredhutch.org/en/faculty-lab-directory/bloom-jesse.html">Jesse Bloom</a>, a virologist who co-authored the study, says. “So we think this suggests that there’s the potential for SARS-CoV-2 to do the same thing.” But Bloom stresses that this process takes years. It’s enough time to prepare, to monitor, and to potentially tweak vaccine formulations to keep up with the virus’s evolution.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lZ6YS1">
|
||
It’s not like the virus can evolve into an entirely different beast. “It can mutate to maybe escape antibodies,” <a href="https://twitter.com/eguia_rachel">Rachel Eguia</a>, the study’s lead author, says. But it can’t change so much that it alters its own ability to enter cells.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hJ7slj">
|
||
Scientists are also keeping their eyes out for a rapid, major mutation event known as <a href="https://www.ncbi.nlm.nih.gov/books/NBK8439/#:~:text=Viral%20recombination%20occurs%20when%20viruses,some%20genes%20from%20both%20parents.">recombination</a>. That’s where an individual is infected with two different strains of the virus at the same time, allowing the virus strains to swap parts. These new viruses could then evade the antibodies that targeted their predecessors. Some researchers think that recombination might be how <a href="https://advances.sciencemag.org/content/6/27/eabb9153">SARS-CoV-2 originated</a> in the first place.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4VYYyZ">
|
||
“This is all hypothetical in this particular virus, but it happens in other viruses all the time,” Neuman said.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1Rc9ZK">
|
||
Faced with these looming challenges, reducing the transmission of the coronavirus in general is still the best way to protect the fragile progress made in the Covid-19 pandemic so far. Reducing transmissions is also one of the best ways to make sure powerful tools like vaccines remain potent for as long as possible. The fact that multiple Covid-19 vaccines are coming out is not a cause for complacency, and these new variants of SARS-CoV-2 highlight how important it is to remain vigilant.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F9NmeZ">
|
||
</p>
|
||
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bishan Bedi asks DDCA to remove his name from stands, quits membership</strong> - The former India captain was angry with idea of an Arun Jaitley statue at the Feroz Shah Kotla in Delhi</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Polls can be held electronically, come with confirmed schedule: HC to Boxing Federation of India</strong> - “A large number of associations are conducting elections through electronic form,” the court observed.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Warner, Abbott to miss second Test against India</strong> - Both the Australian cricketers were outside the team's bio-secure hub to get treatment for their respective groin and calf injuries.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Messi passes Pele as top scorer at a single club</strong> - The Argentine scored his 644th goal for Barcelona</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indian Super League | Four goals but no winner</strong> - Odisha FC and NorthEast United FC (NEUFC) slugged it out in an eventful Indian Super League (ISL) contest which ended 2-2 at Bambolim on Tuesday. Odis</p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘Khaps’ spearhead farmers agitation in Haryana</strong> - State has witnessed a late surge in agitation</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>National Herald case | Subramanian Swamy delaying proceedings: Sonia, Rahul Gandhi tell court</strong> - Sonia Gandhi and Rahul made the submission before the court while opposing an application filed by Subramanian Swamy, seeking summoning of various documents and witnesses in the case.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rajinikanth’s ‘Annaatthe’ shoot postponed after few crew members test positive for coronavirus</strong> - “Superstar Rajinikanth and other crew members have tested negative,” Sun Pictures said through a message on its official twitter page</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gujarat HC discharges NCP MLA Kandhal Jadeja in Arms Act case</strong> - The case was lodged against Jadeja in Porbandar after he was allegedly caught with weapons in 1998.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>High Court rejects Yediyurappa’s plea to quash proceedings in illegal land denotification case</strong> - Declining to quash the case against Mr. Yediyurappa on Tuesday, Justice Michael Cunha directed the Lokayukta special court to monitor the investigation ordered by the courts with regard to the misconduct of MPs, MLAs involved in criminal offences.</p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid-19: Scuffles as hauliers face 'a few days' at UK border</strong> - France has eased its travel ban but lorry drivers need a negative Covid test to travel from the UK.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: Johnson and EU chief in 'close contact' over trade deal push</strong> - Fishing and competition rules remain sticking points in push for pre-Christmas trade agreement.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>France police shootings: Three officers killed by gunman who is later found dead</strong> - Police were investigating domestic violence in a village, and the suspect has now been found dead.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Erdogan attacks Europe court's order for Demirtas's release</strong> - Turkey's president condemns a call by Europe's rights court to free a jailed Kurdish political leader.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Macron's dog Nemo in video plea to be kind to pets</strong> - The French president's pooch sends the Christmas message "adopt with awareness!"</p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
|
||
<ul>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rocket Report: SN9 rolls to the launch pad, SLS “wet dress” test ends early</strong> - "It has surely been a year of challenges." - <a href="https://arstechnica.com/?p=1731449">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The omnibus bill was packed with energy and environment policy</strong> - DOE gets a long list of clean energy R&D projects. - <a href="https://arstechnica.com/?p=1731609">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Let’s Encrypt comes up with workaround for abandonware Android devices</strong> - When you haven't been updated since 2016, expiring certificates are a problem. - <a href="https://arstechnica.com/?p=1731408">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leonardo da Vinci’s drawings have unique microbiomes, study finds</strong> - Research could help slow down deterioration of aging artwork, unmask counterfeits - <a href="https://arstechnica.com/?p=1724965">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Congress creates new copyright court that could make trolling easier</strong> - Congress also made streaming pirated works a felony. - <a href="https://arstechnica.com/?p=1731441">link</a></p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
|
||
<ul>
|
||
<li><strong>I got my covid test results and I'm so confused.. it was just the number 83...</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
On the plus side my IQ test came back positive
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/childsy441"> /u/childsy441 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kidg19/i_got_my_covid_test_results_and_im_so_confused_it/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kidg19/i_got_my_covid_test_results_and_im_so_confused_it/">[comments]</a></span></p></li>
|
||
<li><strong>An Italian guy is out picking up women in Rome. While at his favorite bar, he manages to attract one rather attractive-looking blonde.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
They go back to his place, and sure enough, they go at it. After a long while, he climaxes. Then he rolls over, lights up a cigarette and asks her, “So… you finish?”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
After a short pause, she replies, “No.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
Surprised, but pleasantly, he puts out his cigarette, rolls back on top of her, and has his way with her again, this time lasting even longer than the first. Again he rolls over, lights a cigarette, and asks, “So… you finish?”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
And again, after a short pause, she just says “No.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
Stunned, but still acting reflexively on his macho pride, he once again puts out the cigarette and entertains his companion du jour. This time, with all the strength he can muster up, he barely manages to end the task, but he does, after expending quite a lot of time and energy.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
Barely able to roll over, he reaches for his cigarette, lights it again, and then asks tiredly, “So… you finish?”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
“No. I’m Swedish.”
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ki3me5/an_italian_guy_is_out_picking_up_women_in_rome/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ki3me5/an_italian_guy_is_out_picking_up_women_in_rome/">[comments]</a></span></p></li>
|
||
<li><strong>A young lady in the maternity ward is asked by the midwife if she would like her husband to be present at the birth of her child.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
“I'm afraid I don't have a husband" she replies. "Okay do you have a boyfriend?" asks the Midwife. "No, no boyfriend either".
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
"Do you have a partner then?" "No, I'm not attached to anyone. I'll be having my baby on my own".
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
After the birth the midwife again speaks to the young woman. “You have a healthy bouncing baby girl, but I must warn you before you see her that the baby is black.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
“Well,” replies the girl "I was very down on my luck, with no money and nowhere to live, and so I accepted a job in a porn film. The lead man was black.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
"Oh, I'm very sorry" says the midwife, “that's really none of my business and I'm sorry that I have to ask you these awkward questions but I must also tell you that the baby has blonde hair.” “Well, yes" the girl again replies "you see the co-star in the movie was this Swedish guy.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
"Oh, I'm sorry" the midwife repeats "that's really none of my business either and I hate to pry further but your baby also has slanted eyes.” Yes,” continues the girl "there was a little Chinese man in the movie also, I really had no choice.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
At this, the midwife again apologizes, collects the baby and presents her to the girl, who immediately proceeds to give the baby a slap on the butt.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
The baby starts crying and the mother exclaims "Thank god for that!"
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
“What do you mean?" says the midwife, shocked.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
"Well,” says the girl extremely relieved "I had this horrible feeling that she was going to bark..."
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/nothinlefttochoose"> /u/nothinlefttochoose </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kib4cd/a_young_lady_in_the_maternity_ward_is_asked_by/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kib4cd/a_young_lady_in_the_maternity_ward_is_asked_by/">[comments]</a></span></p></li>
|
||
<li><strong>My SUV needs all 4 tires replaced at a total cost of $800. That's more than the stimulus they gave us and so the wife freaked out a little.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
I told her that it's no big deal and we can just rent a SUV for a day and it would only cost $50.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
She said I was an idiot and that we would need an SUV for more then 24 hours.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
Then I explained to her that it's more then enough time for me to swap the tires.
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Doobiem87"> /u/Doobiem87 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kib747/my_suv_needs_all_4_tires_replaced_at_a_total_cost/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kib747/my_suv_needs_all_4_tires_replaced_at_a_total_cost/">[comments]</a></span></p></li>
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<li><strong>Why did the mermaid wear seashells?</strong> - <!-- SC_OFF -->
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<div class="md">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Because she grew out of b shells
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</p>
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</div>
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<!-- SC_ON -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/ilandedhereyesterday"> /u/ilandedhereyesterday </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kiqncm/why_did_the_mermaid_wear_seashells/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kiqncm/why_did_the_mermaid_wear_seashells/">[comments]</a></span></p></li>
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</ul>
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