558 lines
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558 lines
69 KiB
HTML
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<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-new-yorker">From New Yorker</a></li>
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<li><a href="#from-vox">From Vox</a></li>
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<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
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<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
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<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
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<li><a href="#from-ars-technica">From Ars Technica</a></li>
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<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
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</ul>
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<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
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<ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Plague Year</strong> - The mistakes and the struggles behind America’s coronavirus tragedy. - <a href="https://www.newyorker.com/magazine/2021/01/04/the-plague-year">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Trümperdämmerung Is a Fitting End to 2020</strong> - The President is careening through his final days in office with reckless disdain—for everything. - <a href="https://www.newyorker.com/news/letter-from-trumps-washington/the-trumperdammerung-is-a-fitting-end-to-2020">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Next Big Challenge: Trump-Proofing the Presidency</strong> - Trump’s departure will prompt cries of relief in many parts of the country, but there is now vital work to be done. - <a href="https://www.newyorker.com/news/our-columnists/the-next-big-challenge-trump-proofing-the-presidency">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Deep Origins of Latino Support for Trump</strong> - The leaders of the Hispanic Republican movement today haven’t felt such momentum for twenty years. - <a href="https://www.newyorker.com/news/the-political-scene/the-deep-origins-of-latino-support-for-trump">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can Wall Street’s Heaviest Hitter Step Up to the Plate on Climate Change?</strong> - More significant than BlackRock executives’s pledges is the firm’s continued inclusion of fossil-fuel companies in its index funds. - <a href="https://www.newyorker.com/news/annals-of-a-warming-planet/can-wall-streets-heaviest-hitter-step-up-to-the-plate-on-climate-change">link</a></p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
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<ul>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The UK coronavirus mutation has been found in the US</strong> -
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<figure>
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/z4hiXUP3U9Km0646GDsqupBy98M=/260x0:1820x1170/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68569350/Covid_UK.0.jpg"/>
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<figcaption>
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Illustration by Zac Freeland/Vox
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</figcaption>
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</figure></li>
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</ul>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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What scientists have learned about the Covid-19 variants in the UK, South Africa, and now, the US.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7E5mgC">
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A new, seemingly more contagious variety of SARS-CoV-2 — the virus that causes <a href="https://www.vox.com/coronavirus-covid19">Covid-19</a> — that has been spreading rapidly in the United Kingdom has now been found in the United States in at least two locations.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zduS7x">
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California <a href="https://sacramento.cbslocal.com/2020/12/30/covid-19-mutant-variant-strain-b117-california/">Gov. Gavin Newsom</a> announced December 30 that the new strain, known as B.1.1.7 (we’ll call it the UK variant, for simplicity’s sake), was detected in the southern part of the state. It’s the second report of the UK variant in the US in as many days, following news that the variant was found in a male Colorado National Guard member in his 20s with no history of travel, a sign that the virus is spreading locally.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dCIJyi">
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“There is a lot we don’t know about this COVID-19 variant, but scientists in the United Kingdom are warning the world that it is significantly more contagious,” said Colorado Gov. Jared Polis, in a <a href="https://twitter.com/GovofCO/status/1344031800230780933">statement</a>.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BMyEkP">
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The evidence that this new strain spreads more easily between people is not rock solid, but it’s concerning enough to have forced dramatic action, like shutting down travel <a href="https://www.npr.org/sections/coronavirus-live-updates/2020/12/21/948751745/travel-from-the-u-k-shut-down-as-nations-assess-threat-of-new-coronavirus-strain">from the United Kingdom</a> earlier this month. But it wasn’t enough: The variant has now been detected in <a href="https://www.cbc.ca/news/canada/toronto/ontario-confirms-first-cases-covid19-uk-variant-1.5855361">Canada</a>, <a href="https://www.theguardian.com/world/2020/dec/26/spain-and-sweden-report-cases-of-uk-covid-variant">Spain, Sweden</a>,<a href="https://www.aljazeera.com/news/2020/12/26/which-countries-have-reported-new-variants-of-covid-19"> France, and Italy</a>, among others.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2QC8m1">
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At the moment, it doesn’t appear as though the new UK variant of SARS-CoV-2 is more dangerous in individuals. It doesn’t seem to make people sicker, nor is it more likely to kill them. “I think the key point is that there is no evidence now … that this virus is more pathogenic — creates more problems, more morbidity and mortality — than the previous virus,” <a href="https://www.hhs.gov/about/news/2020/05/15/trump-administration-announces-framework-and-leadership-for-operation-warp-speed.html">Moncef Slaoui</a>, the scientific lead for Operation Warp Speed, said during a December 21 <a href="https://www.youtube.com/watch?v=5G8uPGyDjic">press conference</a>.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UQZE1g">
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What it does appear to do, at least based on preliminary evidence, is spread more quickly among people. That alone is a problem: The coronavirus spreads fast enough as it is. Compounding concerns is that the UK variant echoes a similar story in <a href="https://apnews.com/article/new-coronavirus-strain-south-africa-31a0d5840a17fa5c82f2ecd14ba9921b">South Africa</a>, where a strain called 501.V2 has become the dominant version among new cases of the virus. Scientists are wondering whether that strain is more transmissible, too.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xH22Yl">
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The virus has been continually changing its genetics through the course of the pandemic. That’s what RNA-based viruses like SARS-CoV-2 do — they mutate. Most of the time, the mutations mean nothing. But this time, something is different.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FV0paB">
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“I’ve spent a lot of time this year reminding people that mutations are normal,” molecular epidemiologist <a href="http://emmahodcroft.com/">Emma Hodcroft</a>, who works on a project called <a href="https://nextstrain.org/">Nextstrain</a>, said. For the entire pandemic, scientists the world over have been feeding Nextstrain sequences of the virus, and Hodcroft and her colleagues have been tracking its genetic changes closely.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uimlqr">
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In the past, mutations haven’t warranted big newspaper headlines. “I’m now finding myself singing a slightly different tune,” Hodcroft said. This time, there does seem to be evidence that the new strain is something worth being vigilant about. “We probably should consider taking some precautionary measures while we’re trying to find out more,” she added.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EF6z4U">
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At the same time, Covid-19 is surging around the world, even without these new mutations. Scientists are still trying to figure out what these new variants of the coronavirus actually mean for the pandemic. It’s also unclear where else the UK variant may have already spread, aside from the countries where it has been detected. While it was reported in the US only this week, it could have been in the country for much longer. “The variant could already be in the United States without having been detected,” the US Centers for Disease Control and Prevention <a href="https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html">reported</a> December 22.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3WdEPP">
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The good news is that we already know how to respond to these new variants: in the same way we’ve been responding to the pandemic overall. The virus still transmits primarily through viral-laden breaths in the air. Mask-wearing, social distancing, and good indoor ventilation are as critical as ever.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eAp9uo">
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There’s a lot about this story that’s potentially very alarming or confusing. And the story is not yet complete, as scientists need more evidence to understand whether these new variants pose a new threat.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BGroeT">
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To add some clarity, here’s what researchers have learned so far. Let’s start with the basics.
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</p>
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<h3 id="JqQobE">
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Viral mutations, explained
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</h3>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A4GeiD">
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Viral mutations. New strains. Increased transmission. It all sounds like scary science fiction. But to demystify things, and to understand why scientists are a little concerned about this new variant — and why most variants don’t faze them — it’s worth understanding how viruses mutate in the first place.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OM33h7">
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“Oftentimes, I think the word mutation in general conjures up a lot of things in people’s minds, like, you know, Ninja Turtles or X-Men or cancer, like zombie apocalypse-type stuff,” <a href="https://ghss.georgetown.edu/people/angela-rasmussen/">Angela Rasmussen</a>, a virologist with Georgetown’s Center for Global Health Science and Security, said. “A mutation is just a lot more mundane than that.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YBXhRm">
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Viruses mutate because they’re constantly making copies of themselves in enormous numbers. To accomplish this, they have to hijack the hardware of a host cell that they infect. However, this process can be a bit sloppy.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1wBIEt">
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Within a human body, a virus can replicate itself millions or billions of times, Hodcroft explains. If you were writing a draft of something millions of times on a computer, extremely quickly, you’d probably make some typos. That’s what’s happening with the viruses. “They make a typo” in their genetic code, she says. One letter of their ribonucleic acid (RNA) chain is replaced with another.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0z91lN">
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Viruses that use RNA as their genetic material, like SARS-CoV-2, are particularly vulnerable to mutations since the RNA molecule itself is more unstable than DNA. The process of copying RNA is also more prone to error.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MH9nOj">
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These typos can be very useful for scientists because they happen at a regular rate, and are passed down through generations of the virus as it spreads through a community. Often, scientists can use these subtle changes to trace certain strains’ lineage and their spread through a population.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l0NhR9">
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The majority of these typos are inconsequential when it comes to human health. “One typo, or even a few typos, doesn’t usually change how the virus works,” Hodcroft says. Some even harm the virus. “You’re much more likely to break it than to make it better” when it comes to mutations, she says.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HGkWRP">
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But in rare instances, some mutations can give a virus an advantage, like allowing it to infect cells more readily or spread among people faster. Those mutant strains can then become dominant within a population.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hav0re">
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That might be what we’re looking at here with the UK variant; this new strain may have accumulated typos that could make it more easily transmitted between people.
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</p>
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<h3 id="2dmw3O">
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Four lines of evidence converging on this new mutation being more transmissible
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</h3>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Y51zQ">
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So why do scientists think this variant is more transmissible?
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Jct7w8">
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They don’t have this nailed down yet for sure, but four converging streams of evidence are all pointing in the same direction. “That’s making people feel like maybe there is something here to be worried about,” Hodcroft says. “Each one of these things on their own, I would say is not necessarily convincing.” But all together, they paint a concerning picture.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HpnQaU">
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One is that in the areas of the UK where this new variant is spreading, it is accounting for a larger proportion of new cases. “What this implies is that this new variant is spreading better than other variants that are circulating in the same region,” she says.
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</p>
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<div id="uHkWsG">
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<blockquote class="twitter-tweet">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
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National testing data shows increased prevalence of the variant in positive cases over time. This is detected incidentally by the commonly used 3-gene PCR test because 69-70del leads to a negative signal. But this does not effect the results of the test. 7/<br/>h/t <a href="https://twitter.com/The_Soup_Dragon?ref_src=twsrc%5Etfw"><span class="citation">@The_Soup_Dragon</span></a> <a href="https://t.co/aPpAjjb35W">pic.twitter.com/aPpAjjb35W</a>
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</p>
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— Muge Cevik (<span class="citation">@mugecevik</span>) <a href="https://twitter.com/mugecevik/status/1341094871822680067?ref_src=twsrc%5Etfw">December 21, 2020</a>
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</blockquote>
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</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aY09i5">
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A second is that the increase didn’t co-occur with any overly obvious change in human behavior. “We don’t really have strong evidence that everyone in the southeast [UK where this variant is spreading] has just ripped their masks off and is, you know, totally violating restrictions,” she says. That said, it could be a coincidence. It could be just that people who happen to have contracted this variant have it are spreading it more often via their behavior.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PqgUXB">
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After all, “this new variant has emerged at a time of the year when there has traditionally been increased family and social mixing,” according to the <a href="https://www.ecdc.europa.eu/en/publications-data/threat-assessment-brief-rapid-increase-sars-cov-2-variant-united-kingdom">European Center for Disease Prevention and Control</a>, which estimated that the transmissibility of the new variant has increased by 70 percent compared to prior versions of the virus. Both Rasmussen and Hodcroft say the 70 percent more transmissible figure is most likely an overestimate. A recent, not yet peer-reviewed study from the London School of Hygiene & Tropical Medicine used a mathematical <a href="https://www.nytimes.com/2020/12/23/health/coronavirus-uk-variant.html">model to estimate that the new strain </a>may be 56 percent more infectious.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1zJydD">
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Third, there’s some early data about how this variant acts in Covid-19 patients. “There may be slightly higher viral loads in patients with the variants,” Hodcroft says, suggesting the virus has an easier time replicating in the body. (Viral load refers to the amount of virus in the patient. Rasmussen also cautions that viral load data is really sensitive to timing and when the patient was sampled in the course of the illness, so there needs to be more data to confirm this.)
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="noaKCM">
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Finally, the genetic changes in the UK variant mirror changes in the South African variant, which has also been associated with rising case numbers. That makes a plausible link: that this particular genetic change may be behind the increased transmissibility in both variants.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JtWl8E">
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However, this is still short of definitive confirmation that the new variant is more transmissible.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jEAEmP">
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According to Slaoui, figuring this out for certain would require laboratory animal testing to see how easily the virus can spread from one organism to another. But this testing can take several weeks.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OEUlSn">
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In the face of that uncertainty, many urge caution.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VVoYm6">
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Again, there’s still no evidence this new variant causes more severe disease. The evidence points only to increased transmissibility. But a more transmissible virus is still a concern. “In general, the more people get infected, the number of hospitalizations and deaths rise accordingly as a proportion of that number,” Hodcroft says. “So more cases is also bad news.”
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</p>
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<h3 id="TG5rcr">
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What does the mutation ... do?
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</h3>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5q1EBv">
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The UK variant of SARS-CoV-2 actually contains 23 mutations in the genome of the virus. “We don’t really know what they do,” Rasmussen says. Individually, many of these mutations have already been seen in other strains of the virus around the world. But the combination of these changes in a single virus could be making the new variant more likely to spread.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gdDdxa">
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However, scientists do think that some mutations may be more important than others, and there are several mechanisms by which mutations could make the virus more infectious. Those include:
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZtKOm3">
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</p><ol style="list-style-type: decimal">
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<li>The virus could end up with changes to its spike protein that allow it to enter cells more easily.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g29Sx5">
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</p><ol start="2" style="list-style-type: decimal">
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<li>The virus could develop a mechanism to replicate more quickly inside a body, which would lead “to people becoming infectious faster, or contagious faster than they would with another variant,” Rasmussen explains.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hXzAKl">
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</p><ol start="3" style="list-style-type: decimal">
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<li>The virus could theoretically have evolved an ability to counteract the cell’s innate immune defenses, making it easier to infect that cell.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NCa9u7">
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One of the pathways scientists suspect may be at work stems from the N501Y mutation, where the amino acid asparagine is replaced by the amino acid tyrosine in the 501st position of the viral protein sequence. It’s one of several mutations in the virus’s spike protein in the UK variant, but N501Y is in the part of the spike that actually comes into direct contact with human cells. The same mutation has been found in the South African variant of SARS-CoV-2 that’s also quickly spreading.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nNs6Ei">
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Since the virus attaching to a host cell is critical to the virus’s reproduction, the virus’s spike protein is especially important — and delicate.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F6Wo93">
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“If you were just making random changes in the lab, almost any change you make in that area would result in just a dead virus that can no longer get into the cell,” said <a href="https://tamut.edu/academics/Colleges-and-Departments/CASE/Undergraduate-Programs/Biology/bneumanCV.pdf">Benjamin Neuman,</a> a virologist at Texas A&M University Texarkana. “That fact that this thing is able to spread at all tells you that it’s at least as good as the original version. The fact that it’s spreading faster may indicate that it’s a little bit better at grabbing on to host cells, which is the first step of the entry process.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5jxoC7">
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But this particular N501Y mutation has already been detected in strains that have risen and fallen in other parts of the world over the course of the pandemic. So it may be that the other mutations coupled with N501Y are having some sort of compounding effect. And scientists still need to do more work to determine if this is actually what’s causing the rise of the new SARS-CoV-2 variant in the UK. Finding out the answer could help researchers come up with ways to counter this variety of the coronavirus.
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</p>
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<h3 id="PfqUji">
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How did these coronavirus mutations happen?
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</h3>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cptkXt">
|
||
Scientists don’t know exactly how the UK variant came to be. But there may be a clue. Hodcroft is struck by the sheer number of mutations in the UK variant — 23 in all — which makes her suspect it’s possible this variant arose in an immunocompromised person. “It’s an above-average number of mutations,” she says.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NqsUNm">
|
||
In most people, she explains, the immune system mounts a full-on assault on the virus, eliminating it in a matter of a couple of weeks. “In people that have compromised immune systems, though, there’s a very different dynamic,” she says. “So, for one thing, the virus could be in them for months instead of weeks.” That gives the virus more time to evolve, to accumulate mutations that might make it easier to thwart the immune system.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FzgXMP">
|
||
“It’s one scenario,” she says. “We may never know exactly what happened here.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WEpDLh">
|
||
The basic truth: The more this virus spreads, the more chances there are for dangerous new variants to emerge. In any person — or <a href="https://www.vox.com/science-and-health/2020/12/16/21826130/coronavirus-covid-19-in-animals-mink-dog-cats-gorillas-tigers">animal, for that matter</a> — the chance for a dangerous new variant to arise is rare. But rare things can happen when there are so many cases: more than <a href="https://coronavirus.jhu.edu/map.html">80 million confirmed cases worldwide</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L2CjV5">
|
||
Since viruses like SARS-CoV-2 are mutating and since Covid-19 has spread in so many people, it’s theoretically only a matter of time before a certain set of mutations align in a way to give the virus a boost.
|
||
</p>
|
||
<h3 id="l7vml9">
|
||
What can we do about Covid-19 mutants?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ift3lH">
|
||
To stop mutations, quite simply, we need to stop the spread of SARS-CoV-2 in general. For one, that helps us deal with the pandemic overall. But “that’s also conveniently how we get fewer emerging variants,” Rasmussen says. “If the virus isn’t replicating, it can’t mutate. And if it can’t mutate, the new variants can’t emerge.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r3201F">
|
||
We fight the new variant as we would any variant of SARS-CoV-2: with masks, with social distancing, with good hand hygiene. “I don’t think people should be panicking,” Hodcroft says. “Lower case numbers, no matter what the variant, are better.”
|
||
</p>
|
||
<div id="dHLBFg">
|
||
<blockquote class="twitter-tweet">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
|
||
It’s already been said but if we actually follow protocol and have policies that support those protocols a new variant that is more transmissible would be combatted just as an older variant. So like worry less about mutants and more about masking and distancing and vaccination.
|
||
</p>
|
||
— K. Taylor, Ph.D., M.S. (<span class="citation">@KYT_ThatsME</span>) <a href="https://twitter.com/KYT_ThatsME/status/1340823722136104961?ref_src=twsrc%5Etfw">December 21, 2020</a>
|
||
</blockquote></div></li>
|
||
</ol></li>
|
||
</ol></li>
|
||
</ol>
|
||
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gFk3MS">
|
||
Scientists have one more tool, though: genetic tracking. At Nextstrain, Hodcroft and her colleagues receive viral genetic sequences from all over the world to try to paint a real-time picture of transmission chains and keep tabs on how the virus is changing. But not every place in the world is providing the same amount of data.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="inHwvY">
|
||
The UK does a lot of viral sequencing, for instance. It was able to pick up on the new viral strain quickly because of that. In other locations around the globe, that might not have happened so fast.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="At2rFP">
|
||
“In the US, it’s a really spotty picture,” Hodcroft says when it comes to sequencing. “Some states have really invested in sequencing; some states haven’t. So for some states, we probably have a fair idea of what’s going on. In other states, we really don’t have many sequences.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gtSP21">
|
||
Overall, the CDC <a href="https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html">reports</a> that the US has sequenced only 51,000 of the more than 17 million cases reported in the country. That’s 0.07 percent. In comparison, the UK aims to sequence <a href="https://www.cogconsortium.uk/news_item/how-do-we-collect-and-sequence-sars-cov-2-samples/">10,000 virus samples <em>per week</em></a>, and plans to increase that capacity further. (In addition: The UK sequences the genomes faster than the US,<a href="https://twitter.com/trvrb/status/1341806651225980929"> according to</a> infectious disease researcher Trevor Bedford.) That lack of viral genetic testing creates a big blind spot in the US. The UK variant could have already arrived here undetected “given the small fraction of US infections that have been sequenced,” the CDC <a href="https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html">states</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EqiasJ">
|
||
More sequencing, overall, would lead to the faster detection of new strains and faster means to contain them if they were deemed problematic.
|
||
</p>
|
||
<h3 id="ql7mht">
|
||
Do mutations mean a Covid-19 vaccine won’t work anymore?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WWvya2">
|
||
With new mutations, there is a concern that a new strain of SARS-CoV-2 could arise that would be different enough from previous versions such that prior exposures — whether through a vaccine or an infection — won’t offer protection. So, yes, it’s possible that the coronavirus could someday mutate in a way that would elude a vaccine or previous immunity.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hO8TOl">
|
||
Right now, though, scientists think this UK variant would still fall under the same umbrella of protection as earlier strains. If someone received a Covid-19 vaccine for an older generation of the virus, they would likely have protection against this one.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ugSSo9">
|
||
To explain why, it helps to understand how the immune system deals with viruses. When the human body detects a hostile foreign entity like a virus, it starts to produce antibodies (proteins that attach to the virus or to infected cells). Antibodies can then interfere with how the virus works. They can also flag the virus or virus-infected cells for destruction by other immune cells.
|
||
</p>
|
||
<aside id="dXhC3v">
|
||
<div>
|
||
|
||
</div>
|
||
</aside>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eSM0jG">
|
||
The specific places where the antibodies attach to the virus are called <a href="https://www.britannica.com/science/epitope">epitopes</a>, and most Covid-19 vaccines target epitopes on the virus’s spike protein (which is what the virus uses to attach to human cells and enter them).
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y5VF51">
|
||
“The good thing with the vaccine is that it induces an immune response against several epitopes that have been mapped around the spike protein,” Slaoui said. “The chances that one set of mutations would alter all those epitopes, I think, are extremely very low. The expectation, scientifically, is that these kinds of variations are unlikely to escape fully the protective response by the vaccine.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wLCNdm">
|
||
More good news: Scientists at the University of Texas Medical Branch have announced (<a href="https://twitter.com/TheMenacheryLab/status/1341460341293723650">via a tweet</a>) preliminary evidence that antibodies that neutralize the more common strain of the virus also neutralize a strain with the N501Y mutation (the one that impacts the part of the virus that comes into direct contact with human cells, as mentioned above). That suggests that an immune system primed — by a natural infection, at least — to fight the old variant can also fight one with this specific mutation.
|
||
</p>
|
||
<div id="MO9JSj">
|
||
<blockquote class="twitter-tweet">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
|
||
Some good news (and incredibly fast work) on one of the mutations scientists are worried about: N501Y.<br/>In these lab experiments serum from recovered <a href="https://twitter.com/hashtag/covid19?src=hash&ref_src=twsrc%5Etfw">#covid19</a> patients was just as good at neutralizing virus with the mutation as without it. <a href="https://t.co/SIxfo2x3qp">https://t.co/SIxfo2x3qp</a>
|
||
</p>
|
||
— Kai Kupferschmidt (<span class="citation">@kakape</span>) <a href="https://twitter.com/kakape/status/1341496927318388739?ref_src=twsrc%5Etfw">December 22, 2020</a>
|
||
</blockquote>
|
||
</div>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x22GKL">
|
||
Texas A&M’s Neuman noted that there’s also evidence right now showing how well vaccines can protect against mutated forms of the virus in clinical trials. Many of the vaccines being administered were engineered to counter the earliest generations of SARS-CoV-2 but are still showing themselves to be highly effective against Covid-19 caused by more recent versions of the virus.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XBfVdc">
|
||
“All the tests are being done, all the papers being published, are being done with current strains, which have several mutations relative to [the first iterations of the virus], and it does still seem to be working,” Neuman said.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sKE4P5">
|
||
Covid-19 vaccine developers say they are keeping a close eye on these changes and testing to make sure their vaccines are still effective. “In terms of the new variant, <a href="https://www.vox.com/22167841/fda-vaccine-approval-pfizer-biontech-covid-19-eua-coronavirus">Pfizer and BioNTech</a> are monitoring SARS-CoV-2 sequence changes and the companies are working to generate data on how well serum from people immunized with [the Pfizer/BioNTech vaccine] may be able to neutralize the new strain,” said a Pfizer spokesperson via email.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vRxui9">
|
||
And the new Covid-19 vaccines are well equipped to adapt. The two that have received emergency use authorizations from the Food and Drug Administration — the Pfizer/BioNTech vaccine and the <a href="https://www.vox.com/2020/12/18/22188715/moderna-vaccine-covid-19-fda-emergency-use-authorization-coronavirus">Moderna vaccine</a> — both use <a href="https://www.vox.com/2020/8/13/21359025/coronavirus-vaccine-covid-19-moderna-oxford-mrna-adenovirus">mRNA as their platform</a>. These vaccines deliver the instructions for making the spike protein of SARS-CoV-2 to human cells. Those human cells then manufacture the component themselves, allowing the immune system to use it to prepare for an infection. One huge advantage of this approach is that the mRNA sequence can be altered quickly; the first such vaccines for Covid-19 were <a href="https://nymag.com/intelligencer/2020/12/moderna-covid-19-vaccine-design.html">developed within days</a> after the genetic sequence of the virus was posted online.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UyAQ8q">
|
||
Could manufacturers like Moderna or Pfizer/BioNTech then retool their vaccines to target the new variants without going through the whole tedious clinical trial process again?
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Pt4BOR">
|
||
Possibly, according to <a href="https://globalhealth.georgetown.edu/people/jesse-goodman">Jesse Goodman</a>, a former chief scientist at the FDA and a professor of medicine at Georgetown University. He told Vox that vaccines for new variants of the influenza virus are approved every year without large-scale trials. New versions of a Covid-19 vaccine to accommodate mutations similarly might not need another round of study in tens of thousands of people, but may require some testing to figure out dosing and immune response. With such a new virus and brand new vaccines, the regulations for these situations have not yet been laid out.
|
||
</p>
|
||
<h3 id="ELyZ9T">
|
||
Should we expect more mutations in the future?
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tlkzXx">
|
||
Short answer: yes.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ArUqoF">
|
||
The UK and South African variants are unlikely to be the last to make headlines. Coronavirus is constantly evolving. We should expect it to keep changing slightly.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZEciZz">
|
||
“There will be new variants that emerge,” Rasmussen says. The thing is, with each new significant strain, scientists will have to do careful work to determine whether it’s more dangerous.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uLanYV">
|
||
And there are some mutations we can perhaps even expect — if not in the coming weeks, over the next several years.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pdUaUb">
|
||
Recently, virology researchers at the Fred Hutch Cancer Research Center published a <a href="https://www.biorxiv.org/content/10.1101/2020.12.17.423313v1">preprint</a> (i.e., not yet peer-reviewed) study, looking at how a coronavirus that causes the common cold evolved from the 1980s onward. To accomplish that, they got old blood samples, which included antibodies that cling to this particular virus. They also reconstructed pieces of the cold virus from other eras. Basically, they wanted to see if older blood could still neutralize newer virus. If it couldn’t, that would indicate the virus has evolved over time to evade the immune system.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KBGZ3A">
|
||
Here’s what the researchers found: “This other human coronavirus does indeed evolve over the course of multiple years to gradually escape human immunity,” <a href="https://www.fredhutch.org/en/faculty-lab-directory/bloom-jesse.html">Jesse Bloom</a>, a virologist who co-authored the study, says. “So we think this suggests that there’s the potential for SARS-CoV-2 to do the same thing.” But Bloom stresses that this process takes years. It’s enough time to prepare, to monitor, and to potentially tweak vaccine formulations to keep up with the virus’s evolution.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lZ6YS1">
|
||
It’s not like the virus can evolve into an entirely different beast. “It can mutate to maybe escape antibodies,” <a href="https://twitter.com/eguia_rachel">Rachel Eguia</a>, the study’s lead author, says. But it can’t change so much that it alters its ability to enter cells.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hJ7slj">
|
||
Scientists are also keeping their eyes out for a rapid, major mutation event known as <a href="https://www.ncbi.nlm.nih.gov/books/NBK8439/#:~:text=Viral%20recombination%20occurs%20when%20viruses,some%20genes%20from%20both%20parents.">recombination</a>. That’s where an individual is infected with two different strains of the virus at the same time, allowing the virus strains to swap parts. These new viruses could then evade the antibodies that targeted their predecessors. Some researchers think that recombination might be how <a href="https://advances.sciencemag.org/content/6/27/eabb9153">SARS-CoV-2 originated</a> in the first place.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4VYYyZ">
|
||
“This is all hypothetical in this particular virus, but it happens in other viruses all the time,” Neuman said.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1Rc9ZK">
|
||
Faced with these looming challenges, reducing the transmission of the coronavirus in general is still the best way to protect the fragile progress made in the Covid-19 pandemic so far. Reducing transmissions is also one of the best ways to make sure powerful tools like vaccines remain potent for as long as possible. The fact that multiple Covid-19 vaccines are coming out is not a cause for complacency, and these new variants of SARS-CoV-2 highlight how important it is to remain vigilant.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F9NmeZ">
|
||
</p>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The US is getting an official women’s history museum</strong> -
|
||
<figure>
|
||
<img alt="People walking on the National Mall with the US Capitol in the background." src="https://cdn.vox-cdn.com/thumbor/bW84JbjwN3ERpJUeazO1qHHQoFs=/263x0:4524x3196/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68600105/1207278533.0.jpg"/>
|
||
<figcaption>
|
||
Visitors walk the National Mall in Washington, DC, on March 13, 2020. | Jonathan Newton/The Washington Post via Getty Images
|
||
</figcaption>
|
||
</figure></li>
|
||
</ul>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
The Smithsonian Women’s History Act will establish a women’s history museum on the National Mall. Supporters say it’s long overdue.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="76EiKr">
|
||
It has gotten less attention than expanded unemployment insurance or <a href="https://www.vox.com/2020/12/29/22204468/bernie-sanders-2000-stimulus-checks">the battle over stimulus checks</a>, but tucked into the year-end legislation passed by Congress last week was a provision that could change the way the United States commemorates its history.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lDDXeN">
|
||
The legislation included the Smithsonian Women’s History Act, the culmination of a years-long effort to establish a women’s history museum in Washington, DC. Backed by Democrats like Rep. Carolyn Maloney of New York and Republicans like Sen. Susan Collins of Maine, the act authorizes the creation of the museum on the National Mall, funded by a combination of federal and private money.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Jd3O6Y">
|
||
“For too long, women’s stories have been left out of the telling of our nation’s history, but with this vote, we begin to rectify that,” Maloney said in a statement last week.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I2wgwd">
|
||
The omnibus legislation also included <a href="https://www.congress.gov/bill/116th-congress/house-bill/2420/text">a provision</a> to establish a National Museum of the American Latino, which will focus on “Latino contributions to life, art, history, and culture in the United States.” Both will be located <a href="https://www.washingtonpost.com/entertainment/museums/smithsonian-museums-latino-womens-history/2020/12/22/4f9211ac-43c6-11eb-b0e4-0f182923a025_story.html">on or around the National Mall</a>, with an exact location to be specified within two years, <a href="https://www.cnn.com/2020/12/22/politics/smithsonian-museums-american-latinos-women-trnd/index.html">according to CNN</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q5PywZ">
|
||
The bills establishing the museums were blocked earlier this month by Utah Republican Sen. Mike Lee, who argued that they were divisive. “At this moment in the history of our diverse nation, we need our federal government and the Smithsonian Institution itself to pull us closer together and not further apart,” <a href="https://www.cnbc.com/2020/12/22/congress-agrees-to-fund-national-latino-and-womens-history-museums.html">he said</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yrNMMc">
|
||
But many say that, on the contrary, the museums are long overdue. “Having a museum that features women’s experiences in US history should not be a controversial undertaking by any stretch of the imagination,” Kali Nicole Gross, a professor at Emory University and Rutgers University and co-author of <em>A Black Women’s History of the United States</em>, told Vox. “The fact that it is shows that we have a long way to go still.”
|
||
</p>
|
||
<h3 id="p9erJ1">
|
||
The legislation is the culmination of a years-long process
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JYc6y4">
|
||
The idea of a national women’s history museum first came before Congress in 2003, when Collins and others introduced a bill to establish one, <a href="https://www.cnbc.com/2020/12/22/congress-agrees-to-fund-national-latino-and-womens-history-museums.html">according to CNBC</a>. It didn’t pass, but in 2014, a congressional commission recommended the building of a museum.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vbV2SF">
|
||
Then, in February 2020, <a href="https://www.cnn.com/2020/12/22/politics/smithsonian-museums-american-latinos-women-trnd/index.html">the House passed the Smithsonian Women’s History Act</a> to establish the museum. But passage of both this bill and legislation to establish the Museum of the American Latino was blocked in the Senate by Lee, who said the US does not need “separate but equal museums,” <a href="https://www.cnn.com/2020/12/22/politics/smithsonian-museums-american-latinos-women-trnd/index.html">according to CNN</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YDxAiI">
|
||
The Smithsonian “should not have an exclusive museum of American Latino history or a museum of women’s history or museum of American men’s history or Mormon history or Asian American history or Catholic history. American history is an inclusive story that should unite us,” he added.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FhBYaY">
|
||
But many disagreed, and both proposals ended up included in the omnibus legislation passed last week that included $600 stimulus checks and other Covid-19 relief.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mrpof1">
|
||
Lawmakers have applauded the plans for both museums, expressing hope that they will tell the stories of Americans too often left out of history classes and textbooks.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="olqqoh">
|
||
“With this vote, Latinos and Latinas across our nation will finally have their stories, struggles, and impact on our country validated by the United States Congress,” Sen. Bob Menendez (D-NJ) said in a statement after the legislation’s passage.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="obmR8P">
|
||
And Maloney <a href="https://maloney.house.gov/media-center/press-releases/maloney-celebrates-women-s-museum-legislation-in-omnibus">said in a statement</a> that it was “fitting” that the bill establishing the women’s history museum was passed “as we mark the centennial of the 19th Amendment and in the year in which we elected our first woman vice president.”
|
||
</p>
|
||
<h3 id="rdA9XN">
|
||
There’s a lot of work left to be done
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7zCB0L">
|
||
The museums will likely take years to build. The National Museum of African American History, the most recent addition to the Smithsonian, was authorized by Congress in 2003 and opened in 2016, <a href="https://www.cnn.com/2020/12/22/politics/smithsonian-museums-american-latinos-women-trnd/index.html">CNN notes</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="axqyly">
|
||
And in the planning process, the key will be an “expansive view” of women’s history, Gross said, including women of different abilities, trans and queer communities, and the experiences of women from all walks of life: “women who were performers, women who were writers, women who were seamstresses, women who were farmers, women who were domestics,” she explained. “I want it all.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ue0Tqo">
|
||
Such an expansive view could also extend to more experiential ways of teaching history, Gross said, including the history of street harassment in the US. “From the first women starting to work and having to navigate public streets, there were all kinds of perils,” she explained, especially for Black women. “They carried hatpins; they learned how to use their purses and bags defensively to protect themselves.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v5f6bX">
|
||
It will be interesting to see if the museum could find a way to recreate or use “that embodied experience” to teach about the misogyny that has been a major part of American history, Gross said.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rcQODX">
|
||
Neither the women’s history museum nor the Museum of the American Latino will start from zero. <a href="https://www.washingtonpost.com/entertainment/museums/smithsonian-museums-latino-womens-history/2020/12/22/4f9211ac-43c6-11eb-b0e4-0f182923a025_story.html">According to the Washington Post</a>, they will build on the work of the American Women’s History Initiative, established in 2018, and the Smithsonian Latino Center, founded in 1997. The Women’s History Initiative has launched several exhibitions and has continued to produce virtual events during the pandemic, including <a href="https://womenshistory.si.edu/events">forthcoming programs</a> on female spies during World War II and sexism in science.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MeYtl6">
|
||
Officials at the Smithsonian say their work on such programs will help make the new museums a success. “The Smithsonian has unparalleled experience building national museums, and is already doing significant work to tell the stories of American Women and Latinos,” the institution <a href="https://www.cnn.com/2020/12/22/politics/smithsonian-museums-american-latinos-women-trnd/index.html">said in a statement to CNN</a>. “We look forward to building two world-class museums to further amplify these stories and help our country learn more about the impact that women and Latinos have had on the fabric of our nation.”
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kZV6X2">
|
||
And however they approach the task ahead, the goal should be to make sure “that any woman can walk into that museum and learn about something that they can relate to,” Gross said.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6KTAr4">
|
||
</p>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The UK approved the Oxford/AstraZeneca Covid-19 vaccine. The US might not get it until April.</strong> -
|
||
<figure>
|
||
<img alt="" src="https://cdn.vox-cdn.com/thumbor/fTycZQquwhrTteUHBQvuzmLtlTU=/237x0:4021x2838/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68599797/1230359489.7.jpg"/>
|
||
<figcaption>
|
||
People line up to receive vaccinations on December 30 in London. | Hollie Adams/Getty Images
|
||
</figcaption>
|
||
</figure></li>
|
||
</ul>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
The AstraZeneca vaccine is cheaper and easier to distribute than other vaccines being deployed.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DQYzVR">
|
||
The <a href="https://www.gov.uk/government/news/oxford-universityastrazeneca-covid-19-vaccine-approved">United Kingdom</a> on Wednesday authorized its second <a href="https://www.vox.com/covid-19-coronavirus-treatment-prevention-cure-vaccines">Covid-19 vaccine</a> for distribution. Developed by the University of Oxford and AstraZeneca, the newly approved vaccine costs less and is easier to store than the <a href="https://www.vox.com/2020/12/2/21983642/uk-first-approves-pfizer-vaccine-biontech-covid-19">Pfizer/BioNTech</a> vaccine that received similar approval in the UK on December 2.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NhvZGd">
|
||
Officials said the advantages of the Oxford/AstraZeneca vaccine could accelerate the vaccination effort as the UK contends with a new, <a href="https://www.vox.com/science-and-health/22192061/mutant-coronavirus-covid-19-uk-mutation-vaccine">more transmissible variant</a> of SARS-CoV-2, the virus that causes Covid-19.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GRNvFU">
|
||
“This approval means more people can be protected against this virus and will help save lives,” June Raine, chief executive of the UK’s health regulator, the Medicines and Healthcare products Regulatory Agency, said in a <a href="https://www.gov.uk/government/news/oxford-universityastrazeneca-covid-19-vaccine-approved">statement</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="H3PyEa">
|
||
The UK aims to vaccinate 1 million people per week and is shifting to a more aggressive vaccination schedule, according to the <a href="https://www.nytimes.com/2020/12/30/world/europe/uk-covid-19-vaccine-oxford-astrazeneca.html">New York Times</a>. The country will administer the first vaccine dose to “as many people as possible,” rather than try to keep supplies in reserve to ensure everyone receives a second dose, as other countries, including the United States, have done so far.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Kep7Fp">
|
||
The Oxford/AstraZeneca vaccine’s high stability and low cost could also be a boon to less wealthy nations. If its efficacy is high — and if the vaccine is distributed quickly — it could save countless lives. However, some lingering questions about the results of clinical trials for this vaccine are holding it back from approval in the US, which is conducting its own trials of the vaccine’s effectiveness.
|
||
</p>
|
||
<h3 id="eo9Dv5">
|
||
Why the Oxford/AstraZeneca Covid-19 vaccine is different from those developed by Pfizer/BioNTech and Moderna
|
||
</h3>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YY5UbR">
|
||
In the UK, the Oxford/AstraZeneca vaccine is approved for people over the age of 18 and will normally be administered as two doses spaced four to 12 weeks apart. It<strong> </strong>costs $3 to $4 a dose and can be stored in regular refrigerators. By comparison, the <a href="https://www.vox.com/2020/12/17/22180356/moderna-covid-19-vaccine-approved-fda-emergency-use-pfizer">Moderna</a> and Pfizer/BioNTech vaccines that have received emergency use authorizations in the US cost between $15 and $25 per dose and require freezers. The Pfizer/BioNTech vaccine in particular needs <a href="https://www.vox.com/21552934/moderna-pfizer-covid-19-vaccine-biontech-coronavirus-cold-chain">cold storage</a> at minus 70 degrees Celsius (minus 94 degrees Fahrenheit) or lower.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="isbaDh">
|
||
The Oxford/AstraZeneca vaccine also uses a <a href="https://www.vox.com/2020/8/13/21359025/coronavirus-vaccine-covid-19-moderna-oxford-mrna-adenovirus">different technology</a> from the Covid-19 immunizations approved so far. The Pfizer/BioNTech and Moderna vaccines harness a molecule called mRNA as their platform to deliver the instructions for making a part of the SARS-CoV-2 virus. Oxford and AstraZeneca used a different innovative method, reprogramming another virus to transmit DNA instructions for making parts of the SARS-CoV-2 virus. Using another virus to package and deliver genetic material helps the Oxford/AstraZeneca vaccine remain stable even at higher temperatures.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Cmhk28">
|
||
However, Oxford and AstraZeneca <a href="https://www.vox.com/21590994/oxford-vaccine-results-covid-19-astrazeneca-trial-pfizer-moderna">encountered some problems in their clinical trials</a>, including a dosage mistake that led to one group receiving less than a full dose for their initial shot. So far, its efficacy seems to be less than that of the Moderna and Pfizer/BioNTech vaccines, though well above the 50 percent threshold the Food and Drug Administration and the European Medicines Agency set for vaccine approval.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ahBvS8">
|
||
But the <a href="https://www.vox.com/21590994/oxford-vaccine-results-covid-19-astrazeneca-trial-pfizer-moderna">actual efficacy value</a> remains unclear, ranging between 70 percent and 90 percent efficacy in preventing Covid-19. And Oxford and AstraZeneca have been cagey about certain details surrounding their research.
|
||
</p>
|
||
<aside id="IYTImU">
|
||
<div>
|
||
|
||
</div>
|
||
</aside>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d47yx9">
|
||
One reason the Oxford/AstraZeneca vaccine has been approved in the UK but not in the US is that UK regulators evaluate clinical trial data on a rolling basis. The FDA prefers to have more complete trial data. In the US, <a href="https://clinicaltrials.gov/ct2/show/NCT04516746">phase 3 clinical trials</a> of the Oxford/AstraZeneca vaccine are still being conducted.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KJJBNI">
|
||
During a <a href="https://www.politico.com/news/2020/12/30/astrazeneca-vaccine-april-452371">press call on December 30</a>, Moncef Slaoui, the scientific lead for the US government’s Operation Warp Speed, said it might be months before the US gives this vaccine the green light. “We project, if everything goes well, that the readout and emergency use authorization may be granted somewhere early in the month of April,” Slaoui said.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AZ8gmN">
|
||
But as in the UK, having another vaccine available in the US, particularly one that’s cheaper and easier to store, would help control the spread of Covid-19. The US government has already invested <a href="https://www.hhs.gov/coronavirus/explaining-operation-warp-speed/index.html">$1.2 billion</a> in the Oxford/AstraZeneca vaccine and has committed to purchasing <a href="https://www.hhs.gov/about/news/2020/05/21/trump-administration-accelerates-astrazeneca-covid-19-vaccine-to-be-available-beginning-in-october.html">300 million doses</a>.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="C7HkBL">
|
||
</p>
|
||
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Copper Queen, Eagle Prince, Beauteous Maximus and Towns End please</strong> - Copper Queen, Eagle Prince, Beauteous Maximus and Towns End pleased when the horses were exercised here on Thursday (Dec. 31). Inner sand: 600m: Star</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aus vs Ind third Test | Rohit gears up for Sydney Test with first practice session at MCG</strong> - While Rohit Sharma trained, the rest of the squad took a brief two-day break after India''s fine win in the second Test at MCG.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Goa’s 14-year-old Leon Mendonca becomes India’s 67th Grandmaster</strong> - Mendonca, who achieved the feat at 14 years, 9 months and 17 days, is the second GM from the coastal State.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ICC Test Ranking: Rahane climbs to 6th, Ashwin to 7th, Kohli remains at No. 2</strong> - New Zealand skipper Williamson described it as “humbling” to overtake Smith, who held the top spot for 313 days this year.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs India | Shardul likely to play in Sydney Test, Umesh out of series</strong> - Umesh Yadav had hobbled off the field after suffering the injury during the third day of the Boxing Day Test.</p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBSE Class X, XII exams from May 4 to June 10</strong> - Union Education Minister Ramesh Pokhriyal Nishank on Thursday said Central Board of Secondary Education (CBSE) Class X and Class XII board examination</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ladakh standoff | China, India in talks to hold 9th round of Commander-level meet: Defence Ministry</strong> - At the latest round of foreign ministry-level talks on December 18, the two sides said that they have agreed to continue work towards ensuring complete disengagement of troops</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CVC calls for probe into pending corruption cases to be completed by May 2021</strong> - The vigilance body issues order to secretaries of all central government departments, chief executives of public sector banks, insurance companies and undertakings.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Data firm puts Narendra Modi’s net approval at 55%</strong> - Morning Consult, which carries out surveys and research globally, said in its latest survey that over 75% people approve of Modi while 20% disapprove</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Council of Architecture, architects urge IIM-A not to demolish dorms</strong> - Letters term decision ‘cultural vandalism’, call for restoration of iconic buildings</p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
||
<ul>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: France mobilises 100,000 police to stop New Year's Eve gatherings</strong> - Like other European countries, France will see muted celebrations to mark the last night of the year.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Norway landslide: Houses buried in Gjerdrum village near Oslo</strong> - Ten people are injured and a further 10 are still unaccounted for in Gjerdrum, authorities say.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bosnia: Hundreds of migrants stuck at fire-gutted camp</strong> - About 900 migrants are stranded in the freezing cold after plans to relocate them are blocked.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Giulio Regeni: Italy condemns Egypt for ruling out charges against police</strong> - Italian prosecutors had accused four Egyptian officers of the murder of a Cambridge student in 2016.</p></li>
|
||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: New EU trade arrangements to begin after Parliament vote</strong> - The UK's hard-fought agreement with the EU is set to come into force at 23:00 GMT on Thursday.</p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
|
||
<ul>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Basking shark families go on road trips in search of fine dining</strong> - Genetic tagging offers insight into the secret lives of basking sharks. - <a href="https://arstechnica.com/?p=1732410">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ars Technica’s 2021 Deathwatch—2020 was just the beginning</strong> - These companies might have survived COVID and a recession, but will they survive 2021? - <a href="https://arstechnica.com/?p=1728271">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>That time physicist John Wheeler left classified H-bomb documents on a train</strong> - The whereabouts of the documents remains a mystery to this day. - <a href="https://arstechnica.com/?p=1732329">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Corellium notches partial victory in Apple iOS copyright case</strong> - Security firm's actions both may and may not qualify under fair use, judge held. - <a href="https://arstechnica.com/?p=1732395">link</a></p></li>
|
||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>With the right catalyst, we might make jet fuel from CO₂</strong> - As carbon capture gets cheaper, new applications could look attractive. - <a href="https://arstechnica.com/?p=1732362">link</a></p></li>
|
||
</ul>
|
||
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
|
||
<ul>
|
||
<li><strong>My girlfriend surprised me tonight: she dressed up sexy like a police woman, handcuffed me to the bed and arrested me on suspicion of being good in bed.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
2 minutes later I was released due to lack of evidence.
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Po1sonator"> /u/Po1sonator </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/knjyuo/my_girlfriend_surprised_me_tonight_she_dressed_up/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/knjyuo/my_girlfriend_surprised_me_tonight_she_dressed_up/">[comments]</a></span></p></li>
|
||
<li><strong>In 2017, i didn’t jog. In 2018 i didn’t jog. In 2019 i didn’t jog. In 2020 i didn’t jog.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
This is a running joke
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/theblackviper69"> /u/theblackviper69 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/knjt2p/in_2017_i_didnt_jog_in_2018_i_didnt_jog_in_2019_i/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/knjt2p/in_2017_i_didnt_jog_in_2018_i_didnt_jog_in_2019_i/">[comments]</a></span></p></li>
|
||
<li><strong>Reddit should rename 'share' to 'spreddit', 'delete' to 'shreddit' and 'karma' to 'creddit'.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
Yet they haven't. I don't geddit.
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/RockManDan"> /u/RockManDan </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kneldj/reddit_should_rename_share_to_spreddit_delete_to/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kneldj/reddit_should_rename_share_to_spreddit_delete_to/">[comments]</a></span></p></li>
|
||
<li><strong>A blonde, a brunette, and a redhead walk into a restaurant.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
They are having a fun time and give their waitress a huge tip. Super excited about the tip, the waitress decides to tell them a secret: In the women's bathroom, there is a magical mirror. If you tell it something truthful, you will be greatly rewarded. However, if you lie to the mirror, you will disappear in a poof."
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
Excited to try this mirror out, the women rush to the restroom. The brunette decides to show off and claim she is the most beautiful girl there. "I think I'm the most beautiful person at this restaurant." A million dollars appears in her hands.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
The redhead is feeling a little offended. She decides to show off how smart she is: "I think I'm the smartest person in this restaurant." The keys to a lamborghini magically show up in her purse.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
The blonde, super excited to get something really cool, starts to tell the mirror something: "I think--" poof. she is never seen again
|
||
</p>
|
||
</div>
|
||
<!-- SC_ON -->
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/ZealousidealRise7"> /u/ZealousidealRise7 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kngxkr/a_blonde_a_brunette_and_a_redhead_walk_into_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kngxkr/a_blonde_a_brunette_and_a_redhead_walk_into_a/">[comments]</a></span></p></li>
|
||
<li><strong>A man tells his friend he just opened a brothel.</strong> - <!-- SC_OFF -->
|
||
<div class="md">
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||
“$100 for anal and $50 for a blow job”, says the man.
|
||
</p>
|
||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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His friend asks “How much for the pussy?”.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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“Nah” says the man, “I don’t have any employees yet”.
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</p>
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</div>
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<!-- SC_ON -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/RhinoVanHorn"> /u/RhinoVanHorn </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kn4v5r/a_man_tells_his_friend_he_just_opened_a_brothel/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kn4v5r/a_man_tells_his_friend_he_just_opened_a_brothel/">[comments]</a></span></p></li>
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</ul>
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