Covid-19 Sentry

Contents

• From Preprints
• From Clinical Trials
• From PubMed
• From Patent Search

From Preprints

• Knowledge, attitudes, and practices (KAP) towards COVID-19: A quick online cross-sectional survey among Tanzanian residents. -

  Background The COVID19 pandemic is a global health and societal emergency that requires the adoption of Unprecedented measures to control the rapid spread of the ongoing COVID19 epidemic. Residents9 adherence to control measures is affected by their knowledge, attitudes, and practices (KAP) towards the disease, therefore. This study was carried out to investigate KAP towards COVID-19 KAP among residents in Tanzania during the period of the epidemic. Methods This was a crosssectional study that involved a sample of online Tanzanian residents who was recruited randomly by sending an invitation asking to answer my survey". Survey Monkey tool was used to develop a link and KAP questionnaire for data collection. Participants self-selected themselves when they choose to answer the questionnaire. The questionnaire assessed demographic characteristics of participants, Knowledge, attitude, and practice toward COVID. simple descriptive to complex analyses of multivariate was carried out using SPSS 17. Results Four hundred residents completed a survey. The mean age of study participants was 32 years, and majorities were females 216 (54.0%). There were no significant differences in demographic variables (p>0.3). Those who held a bachelor9s degree or above (60.3%) had a more correct score. Overall, (84.4%) of participants had good knowledge which was significantly associated with education level (p=0.001). Nearly all of the participants (96.0%) had confidence that COVID-19 will be eliminated. The majority of the respondents (77%) did not go to a crowded place in recent days. Multiple linear regression analysis showed that male gender, age-group of 16-29 years, and education of secondary or lower were significantly associated with lower knowledge score. Conclusion Our findings revealed good knowledge, optimistic attitudes, and appropriate practices towards COVID-19. Suggesting that a community-based health education program about COVID-19 is helpful and necessary to control the disease.

  🖺 Full Text HTML: Knowledge, attitudes, and practices (KAP) towards COVID-19: A quick online cross-sectional survey among Tanzanian residents.
• New York City Jails: COVID Discharge Policy, Data Transparency, and Reform -
  During the early stages of the COVID-19 pandemic in 2020, Mayor Bill de Blasio ordered the release of individuals incarcerated in New York City jails who were at high risk of contracting the disease and at low risk of committing criminal reoffense. Using public information, we construct and analyze a database of nearly 350,000 incarceration episodes in the city jail system from 2014 – 2020, paying special attention to what happened during the week of March 23 – 29, 2020, immediately following the mayor’s order. In concordance with de Blasio’s stated policy, we find that being discharged during this focus week is associated with a lower probability of readmission as compared to being discharged during the same calendar week in previous years. Furthermore, comparing the individuals discharged during the focus week of 2020 to those discharged during the same calendar week in previous years, we find that the former group was, on average, slightly older than the latter group, although the difference is not large. Additionally, the individuals in the former group had spent substantially longer in jail than those in the latter group. With the release of long-serving individuals demonstrated to be feasible, we also examine how the jail population would have looked over the past six years had caps in incarceration been in place. With a cap of one year, the system would experience a 15% decrease in incarceration. With a cap of 100 days, the reduction would be over 50%. Because our results are only as accurate as New York City’s public-facing jail data, we discuss numerous challenges with this data and suggest improvements related to the incarcerated individual’s age, gender, race, and more. Finally, we discuss the policy implications of our work, highlight some opportunities and challenges posed by incarceration caps, and suggest key areas for reform. One such reform might involve identifying and discharging low-risk individuals sooner in general, which might be feasible given the de Blasio administration’s actions during the early stages of COVID-19.
  🖺 Full Text HTML: New York City Jails: COVID Discharge Policy, Data Transparency, and Reform
• Prioritizing interventions for preventing COVID-19 outbreaks in military basic training -

  Like other congregate living settings, military basic training has been subject to outbreaks of COVID-19. We sought to identify improved strategies for preventing outbreaks in this setting using an agent-based model of a hypothetical cohort of trainees on a U.S. Army post. Our analysis revealed unique aspects of basic training that require customized approaches to outbreak prevention, which draws attention to the possibility that customized approaches may be necessary in other settings, too. In particular, we showed that introductions by trainers and support staff may be a major vulnerability, given that those individuals remain at risk of community exposure throughout the training period. We also found that increased testing of trainees upon arrival could actually increase the risk of outbreaks, given the potential for false-positive test results to lead to susceptible individuals becoming infected in group isolation and seeding outbreaks in training units upon release. Until an effective transmission-blocking vaccine is adopted at high coverage by individuals involved with basic training, need will persist for non-pharmaceutical interventions to prevent outbreaks in military basic training. Ongoing uncertainties about virus variants and breakthrough infections necessitate continued vigilance in this setting, even as vaccination coverage increases.

  🖺 Full Text HTML: Prioritizing interventions for preventing COVID-19 outbreaks in military basic training
• Unexposed populations and potential COVID-19 burden in European countries as of 21st November 2021 -

  We estimate the potential remaining COVID-19 burden in 19 European countries by estimating the proportion of each country9s population that has acquired immunity to severe disease through infection or vaccination. Our results suggest that many European countries could still face a substantial burden of hospitalisations and deaths, particularly those with lower vaccination coverage, less historical transmission, and/or older populations. Continued non- pharmaceutical interventions and efforts to achieve high vaccination coverage are required in these countries to limit severe COVID-19 outcomes.

  🖺 Full Text HTML: Unexposed populations and potential COVID-19 burden in European countries as of 21st November 2021
• Interferon Resistance of Emerging SARS-CoV-2 Variants -
  The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-CoV-2 infection, combined with the presence of viral genes that limit these responses, suggest that interferons may also influence SARS-CoV-2 evolution. Here, we compared the potency of 17 different human interferons against multiple viral lineages sampled during the course of the global outbreak, including ancestral and four major variants of concern. Our data reveal increased interferon resistance in emerging SARS-CoV-2 variants, suggesting that evasion of innate immunity may be a significant, ongoing driving force for SARS-CoV-2 evolution. These findings have implications for the increased lethality of emerging variants and highlight the interferon subtypes that may be most successful in the treatment of early infections.
  🖺 Full Text HTML: Interferon Resistance of Emerging SARS-CoV-2 Variants
• Predicting Depression and Anxiety Among Adults with Disabilities During the COVID-19 Pandemic -
  Purpose/Objective: Emerging research has highlighted sources of magnified stress and trauma for people with disabilities during the COVID-19 pandemic, as compared to others in the general population. However, little research has examined the mental health impact of the pandemic on people with disabilities in relation to disability-related stigma, social isolation, and demographic characteristics. The present study therefore sought to identify predictors of depression and anxiety symptoms among U.S. adults with disabilities during the COVID-19 pandemic. Research Methods/Designs: Data were collected online between October and December 2020. U.S. adults with disabilities (n =

441. completed self-report measures of depression, anxiety, psychosocial processes, and a range of demographic and disability characteristics. Results: In our sample, 61.0% and 50.0% of participants met criteria for a probable diagnosis of major depressive disorder and generalized anxiety disorder, respectively. Participants also experienced significantly higher levels of disability-related stigma and social isolation compared to pre-pandemic norms. Hierarchical regression analyses identified higher social isolation, presence of chronic pain, younger age, higher disability-related stigma, and higher worries about contracting COVID-19 as significant predictors of both depression and anxiety symptoms. Conclusion/implications: This study highlights important demographic and psychosocial predictors of mental health risks for people with disabilities in the context of COVID-19. Findings further underscore the need to attend to those at elevated risk within the disability community as rehabilitation professionals, disability organizations, and policymakers work to support people with disabilities in post-pandemic recovery and create a more equitable response to ongoing and future public health crises.
     🖺 Full Text HTML: Predicting Depression and Anxiety Among Adults with Disabilities During the COVID-19 Pandemic

• Narrative identity among people with disabilities during the COVID-19 pandemic: The interdependent self -
  This study examines narrative identity among a large, diverse (American) sample of people with disabilities (PWDs) during the “second wave” of the COVID-19 pandemic (October-December, 2020). The study relied on abductive analyses, combining a purely inductive phase of inquiry followed by two rounds of investigation that filtered inductive insights through three theoretical lenses: social-ecological theory, the theory of narrative identity, and perspectives from the interdisciplinary field of disability studies. The central result was the identification of a particular configuration of self, one that was demonstrably interdependent with both immediate interpersonal contexts and with broader cultural contexts. This interdependent self was interpreted in both positive and negative ways by PWDs. These findings invite future inquiry into commonplace conceptualizations of an independent self at the center of personality research.

• Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2 -
  SARS-CoV-2 infection in immunocompromised individuals is associated with prolonged virus shedding and the evolution of viral variants. Rapamycin and its analogs (rapalogs, including everolimus, temsirolimus, and ridaforolimus) are FDA- approved as mTOR inhibitors in clinical settings such as cancer and autoimmunity. Rapalog use is commonly associated with increased susceptibility to infection, which has been traditionally explained by impaired adaptive immunity. Here, we show that exposure to rapalogs increases susceptibility to SARS-CoV-2 infection in tissue culture and in immunologically naive rodents by antagonizing the cell-intrinsic immune response. By identifying one rapalog (ridaforolimus) lacking this function, we demonstrate that rapalogs promote Spike-mediated entry into cells by triggering the lysosomal degradation of IFITM2 and IFITM3. Rapalogs that promote virus entry inhibit the mTOR-mediated phosphorylation of TFEB, a transcription factor controlling lysosome biogenesis and degradative capacity. In the hamster model of infection, injection of rapamycin four hours prior to virus exposure resulted in elevated virus titers in lungs and accelerated weight loss, while ridaforolimus had milder effects. Furthermore, rapamycin significantly elevated mouse-adapted SARS-CoV-2 titers in lungs of mice. Overall, our findings indicate that preexisting use of certain rapalogs may elevate host susceptibility to SARS-CoV-2 infection and disease by activating a lysosome-mediated suppression of intrinsic immunity.
  🖺 Full Text HTML: Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2
• How common are high-risk coronavirus contacts? A video-observational analysis of outdoor public place behavior during the COVID-19 pandemic -
  Epidemiological evidence and recommendations from the World Health Organization (WHO) suggest that close face-to- face interactions pose a particular coronavirus transmission risk. The real-life prevalence and nature of such high-risk contacts are understudied, however. Here, we video-observed high-risk contacts in outdoor public places in Amsterdam, the Netherlands, during the COVID-19 pandemic. We found that high-risk contacts were relatively uncommon. Of the 7,814 individuals observed, only 20 (0.26%) displayed such contact. The estimated rate of high-risk contacts increased by two percentage points for each additional observation minute. Further, we qualitatively examined the 20 high-risk contacts identified and found that they occurred disproportionally between affiliated persons, engaged in affiliative behaviors. Given the relatively low incident rate of high-risk contacts, the current results alleviate the public health concern regarding coronavirus transmission in outdoor public places.
  🖺 Full Text HTML: How common are high-risk coronavirus contacts? A video- observational analysis of outdoor public place behavior during the COVID-19 pandemic
• COVID-19 Vaccine Segments in Australia: An Audience Segmentation Analysis to Improve Vaccine Uptake -
  Background Knowing your audience is the first step in an effective public health communication campaign. While previous studies provide broad categories of public intentions to get a COVID-19 vaccine, few systematically segment and identify effective ways to engage with distinct publics to improve COVID-19 vaccine uptake. Methods Using data from a national sample of Australian public (N = 1054) and based on the Theory of Planned Behaviour, a latent class analysis of 23 items was undertaken to identify COVID-19 audience segments for potential future message targeting. Findings We found five different segments on COVID-19 vaccine intentions: Vaccine enthusiasts (28%), supporters (26%), socials (20%), hesitant (15%), and sceptics (10%). While the vaccine hesitants have concerns about safety and side- effects of the vaccine, the sceptics hold additional concerns about the need for a vaccine and dismiss the health risks. Vaccine socials hold less favourable attitudes towards a COVID-19 vaccine but are willing to get one to protect others. These audience segments differ on demographic variables and in their level of trust in mainstream media, scientists and health experts, social media, and family and friends. In particular, we found the most vulnerable—the poor and undereducated—may need further help in understanding the need and importance of COVID-19 vaccination. Interpretation Understanding the COVID-19 vaccine attitudinal and information seeking characteristics of these sub-publics will help inform appropriate messaging campaigns to reach out to vaccine hesitant and sceptics for promoting vaccination. It provides insight into what types of message framing may be effective, through which platforms messages should be provided, and by which trusted sources.
  🖺 Full Text HTML: COVID-19 Vaccine Segments in Australia: An Audience Segmentation Analysis to Improve Vaccine Uptake
• SARS CoV-2 Post Vaccination Syndrome and VINAIDS -
  Most children and healthy young adults should have never received SARS CoV-2 Vaccines. Inactivated SARS CoV-2 vaccines are safer than nucleic acid-based ones. 0-14 days regimen is probably better than 0-21 days regimen for inactivated SARS CoV-2 vaccines. Post vaccination syndrome is analogous to post or para COVID-19 syndrome (long haulers). Nucleic acid-based vaccines could cause vaccine induced novel acute immune dysrhythmic syndrome.
  🖺 Full Text HTML: SARS CoV-2 Post Vaccination Syndrome and VINAIDS
• “Any advice for a pre-dad who is freaking out?”: A qualitative analysis of paternal perinatal experiences during the COVID-19 pandemic using the reddit forum predaddit -
  During the COVID-19 pandemic, new parents were disproportionately affected due to public health restrictions that changed service accessibility and increased stressors. Yet, minimal research to date has examined specific pandemic- related stressors and experiences of perinatal fathers in naturalistic anonymous settings. An important and relatively novel way parents seek connection and information is through online forum use, which increased during the social isolation of the pandemic. The current study qualitatively analyzed the experiences of perinatal fathers from September to December 2020 (792 posts, 8011 comments) through Framework Analytic Approach to identify unmet support needs during COVID-19 using the online subforum, predaddit. Five main themes emergent in the thematic framework included forum use, COVID-19, psychosocial distress, family functioning, and child health and development, each of which contained related subthemes. Findings highlight the utility of predaddit as a source of information for and interactions of fathers to inform mental health services.
  🖺 Full Text HTML: “Any advice for a pre-dad who is freaking out?”: A qualitative analysis of paternal perinatal experiences during the COVID-19 pandemic using the reddit forum predaddit
• Goal adjustment capacities in uncontrollable life circumstances: Benefits for psychological well-being during COVID-19 -
  Goal adjustment capacities (i.e., goal disengagement and goal reengagement) are core self-regulatory resources theorized to buffer psychological well-being during intractable life circumstances. However, research has yet to examine whether these capacities protect well-being for individuals who encounter uncontrollable losses in their ability to pursue important life goals due to the COVID-19 pandemic. Using a nationally-representative sample of American adults aged 18-80 (n = 292), the present longitudinal study examined the influence of goal disengagement and reengagement on levels and change in psychological well-being for individuals who differed in perceived control over their goals early in the pandemic. Results from multilevel growth models showed that goal reengagement, but not goal disengagement, capacities predicted higher levels of well-being (lower perceived stress, depressive symptoms; higher life satisfaction, meaning in life) for individuals who reported pandemic-induced declines in control over their goals. Findings inform theories of motivation and self-regulation and point to the adaptive value of goal reengagement capacities during uncontrollable life circumstances.
  🖺 Full Text HTML: Goal adjustment capacities in uncontrollable life circumstances: Benefits for psychological well-being during COVID-19
• Researching Employee Experiences and Behavior in Times of Crisis: Theoretical and Methodological Considerations and Implications for Human Resource Management -
  Over the past two years, numerous empirical studies in the fields of human resource management, organizational behavior, and industrial, work, and organizational psychology have investigated employee experiences and behavior during the COVID-19 pandemic. The goal of this paper is to take a step back and to outline several theoretical and methodological considerations when researching employee experiences and behavior in times of crisis more generally. These insights may be useful when developing conceptual models, designing empirical studies, and managing people in the context of future crises. We first review theoretical approaches that could be applied to explain changes in employee experiences and behavior in times of crisis, including stress theories, theories of adjustment to work-related changes, career construction theory, event system theory, transition-adaptation theories, the crisis management and resilience framework, and the social identity model of identity change. Second, we outline methodological considerations and best practices regarding the research design of quantitative empirical studies, sampling, measurement, and analytic strategies. Throughout, we highlight empirical studies on employee experiences and behavior during the COVID-19 pandemic that have adopted these theoretical approaches and methodological best practices. We conclude with several suggestions for future theory development and empirical studies on employee experiences and behavior as well as human resource management in times of crisis.
  🖺 Full Text HTML: Researching Employee Experiences and Behavior in Times of Crisis: Theoretical and Methodological Considerations and Implications for Human Resource Management
• Estimating Active Cases of COVID-19 -

  Having accurate and timely data on active COVID-19 cases is challenging, since it depends on the availability of an appropriate infrastructure to perform tests and aggregate their results. In this paper, we consider a case to be active if it is infectious, and we propose methods to estimate the number of active infectious cases of COVID-19 from the official data (of confirmed cases and fatalities) and from public survey data. We show that the latter is a viable option in countries with reduced testing capacity or infrastructures.

  🖺 Full Text HTML: Estimating Active Cases of COVID-19

From Clinical Trials

• Using MOST to Optimize an Intervention to Increase COVID-19 Testing for Frontline Essential Workers - Conditions:   COVID-19;   COVID-19 Testing
  Interventions:   Behavioral: Motivational interviewing

1001. counseling;   Behavioral: Text messages (TMs) and quiz questions (QQs);   Behavioral: Peer education;   Behavioral: Access to COVID testing
      Sponsor:   New York University
      Not yet recruiting

• Australian Phase 2/3b Study to Assess Effectiveness of a Protein-based Covid-19 Vaccine (Spikogen) - Condition:   COVID-19
  Intervention:   Biological: Spikogen/Covax-19
  Sponsors:  
  Vaxine Pty Ltd;   Australian Respiratory and Sleep Medicine Institute;   Cinnagen
  Not yet recruiting

• COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age - Condition:   COVID-19
  Intervention:   Drug: casirivimab+imdevimab
  Sponsor:  
  Regeneron Pharmaceuticals
  Recruiting

• GlowTest COVID-19 Antigen Home Test Kit QRI Use Study - Condition:   Covid 19
  Intervention:   Diagnostic Test: GlowTest COVID-19 Antigen Home Test
  Sponsors:   Arion Bio;   CSSi Life Sciences
  Not yet recruiting

• Efficacy of Different COVID-19 Vaccine Combinations in Inducing Long-term Humoral Immunity [PRIBIVAC] - Condition:   COVID-19
  Interventions:   Biological: Homologous mRNA booster vaccine;   Biological: Heterologous mRNA booster vaccine;   Biological: Non-mRNA booster vaccine A;   Biological: Non- mRNA booster vaccine B;   Biological: Non-mRNA booster vaccine C
  Sponsors:   Tan Tock Seng Hospital;   A*Star;   Duke-NUS Graduate Medical School;   KK Women’s and Children’s Hospital
  Recruiting

• Study of GRT-R910 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Boost Vaccine in Healthy Volunteers - Condition:   COVID-19
  Interventions:   Biological: GRT-R910 booster 113 days after prime;   Biological: GRT-R910 booster 28 days after prime
  Sponsor:   Gritstone Oncology, Inc.
  Recruiting

• Safety and Immunogenicity of COVID-19 Vaccine, Inactivated in Healthy Population Aged From 3 to 11 Years - Condition:   COVID-19
  Intervention:   Biological: COVID-19 Vaccine,Inactivated
  Sponsor:   Sinovac Biotech Co., Ltd
  Not yet recruiting

• Study of Immunogenicity Equivalence of a Homologous Third Dose of Covid-19 (Recombinante) Vaccine - Condition:   COVID-19
  Intervention:   Biological: Covid -19 (recombinante) vaccine
  Sponsor:   The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
  Recruiting

• Study to Evaluate the Safety and Efficacy of a Monoclonal Antibody Cocktail for the Prevention of COVID-19 - Condition:   COVID-19
  Interventions:   Drug: ADM03820;   Other: Placebo
  Sponsors:  
  Ology Bioservices;   Enabling Biotechnologies (EB)
  Not yet recruiting

• Communities Fighting COVID-19! - Condition:   Covid19
  Interventions:   Other: COVID-19 Testing Home-based (Aim 1);   Other: COVID-19 Testing Mobile (Aim 1);   Other: COVID-19 Testing Mobile Approach 1 (Aim 2);   Other: COVID-19 Testing Mobile Approach 2 (Aim 2)
  Sponsors:   San Diego State University;   National Cancer Institute (NCI)
  Recruiting

• Usefulness of DORNASE in COVID-19 on HFNO - Condition:   COVID-19 Pneumonia
  Intervention:   Procedure: inhalations
  Sponsor:  
  University Medical Centre Ljubljana
  Not yet recruiting

• Communities Fighting COVID Return to School - Condition:   COVID-19
  Interventions:   Behavioral: At-home COVID-19 testing;   Behavioral: Family- based model;   Behavioral: Onsite COVID-19 testing
  Sponsors:   San Diego State University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  Recruiting

• Phase Ⅱ and Ⅲ Trial of a SARS-CoV-2 Vaccine LYB001 - Condition:   COVID-19
  Interventions:   Biological: LYB001;   Biological: Placebo
  Sponsor:   Yantai Patronus Biotech Co., Ltd.
  Not yet recruiting

• The Effect of Micellized Food Supplements on Health-related Quality of Life in Patients With Post-acute COVID-19 Syndrome. - Condition:   Post-acute COVID-19 Syndrome
  Intervention:   Dietary Supplement: Curcumin/Boswellia Serrata/Ascorbic acid mixture
  Sponsor:   PhysioMetrics
  Not yet recruiting

• Safety and Immunogenicity of Recombinant Protein RBD Fusion Dimer Vaccine Against the Virus That Cause COVID-19, Known as Severe Acute Respiratoy Syndrome Coronavirus 2 (SARS-CoV-2) - Conditions:   COVID-19;   SARS-CoV-2 Acute Respiratory Disease
  Interventions:  
  Biological: COVID-19 Vaccine HIPRA;   Biological: Cominarty (Pfizer-BioNtech)
  Sponsors:  
  Hipra Scientific, S.L.U;   Laboratorios Hipra, S.A.;   National Institute of Hygiene and Epidemiology, Vietnam
  Recruiting

From PubMed

• The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting - Programmed ribosomal frameshifting (PRF) is a fundamental gene expression event in many viruses, including SARS-CoV-2. It allows production of essential viral, structural and replicative enzymes that are encoded in an alternative reading frame. Despite the importance of PRF for the viral life cycle, it is still largely unknown how and to what extent cellular factors alter mechanical properties of frameshift elements and thereby impact virulence. This prompted us to comprehensively dissect the…

• Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies - Lectins or clusters of carbohydrate-binding proteins of non-immune origin are distributed chiefly in the Plantae. Lectins have potent anti-infectivity properties for several RNA viruses including SARS-CoV-2. The primary purpose of this review is to review the ability of lectins mediated potential biotherapeutic and bioprophylactic strategy against coronavirus causing COVID-19. Lectins have binding affinity to the glycans of SARS-COV-2 Spike glycoprotein that has N-glycosylation sites. Apart from…

• A rapid real-time polymerase chain reaction-based live virus microneutralization assay for detection of neutralizing antibodies against SARS-CoV-2 in blood/serum - CONCLUSION: We describe a rapid RT-PCR-based SARS-CoV-2 microneutralization assay for the detection of neutralizing antibodies. This can effectively be used to test the antiviral activity of serum antibodies for the investigation of both disease-driven and vaccine-induced responses.

• Unexplained arterial thrombosis: approach to diagnosis and treatment - Arterial thrombotic events in younger patients without a readily apparent etiology present significant diagnostic and management challenges. We present a structured approach to diagnosis with consideration of common causes, including atherosclerosis and embolism, as well as uncommon causes, including medications and substances, vascular and anatomic abnormalities, systemic disorders, and thrombophilias. We highlight areas of management that have evolved within the past 5 years, including the use…

• Is pregnancy a risk factor for in-hospital mortality in reproductive-aged women with SARS-CoV-2 infection? A nationwide retrospective observational cohort study - CONCLUSIONS: With the adjustment for intervention that was shown to be an independent factor associated with mortality, pregnancy appeared to have a favorable effect on SARS-CoV-2 infection. Given the immunosuppressed state of pregnancy, this finding is in line with the hypothetical protective role of a weaker immune response that inhibits the production of proinflammatory cytokine. With the adjustment for intervention, pregnancy was found associated with more favorable outcome of COVID-19, in…

• A Report on Multi-Target Anti-Inflammatory Properties of Phytoconstituents from Monochoria hastata (Family: Pontederiaceae) - This study aims to investigate the potential analgesic properties of the crude extract of Monochoria hastata (MH) leaves using in vivo experiments and in silico analysis. The extract, in a dose-dependent manner, exhibited a moderate analgesic property (~54% pain inhibition in acetic acid-induced writhing test), which is significant (** p < 0.001) as compared to the control group. The complex inflammatory mechanism involves diverse pathways and they are inter- connected. Therefore, multiple…

• Computational Simulation of HIV Protease Inhibitors to the Main Protease (Mpro) of SARS-CoV-2: Implications for COVID-19 Drugs Design - SARS-CoV-2 is highly homologous to SARS-CoV. To date, the main protease (Mpro) of SARS-CoV-2 is regarded as an important drug target for the treatment of Coronavirus Disease 2019 (COVID-19). Some experiments confirmed that several HIV protease inhibitors present the inhibitory effects on the replication of SARS-CoV-2 by inhibiting Mpro. However, the mechanism of action has still not been studied very clearly. In this work, the interaction mechanism of four HIV protease inhibitors Darunavir…

• Involvement of the ACE2/Ang-(1-7)/MasR Axis in Pulmonary Fibrosis: Implications for COVID-19 - Pulmonary fibrosis is a chronic, fibrotic lung disease affecting 3 million people worldwide. The ACE2/Ang-(1-7)/MasR axis is of interest in pulmonary fibrosis due to evidence of its anti-fibrotic action. Current scientific evidence supports that inhibition of ACE2 causes enhanced fibrosis. ACE2 is also the primary receptor that facilitates the entry of SARS-CoV-2, the virus responsible for the current COVID-19 pandemic. COVID-19 is associated with a myriad of symptoms ranging from asymptomatic…

• Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity - Human cytomegalovirus (HCMV) is a major pathogenic herpesvirus that is prevalent worldwide and it is associated with a variety of clinical symptoms. Current antiviral therapy options do not fully satisfy the medical needs; thus, improved drug classes and drug-targeting strategies are required. In particular, host-directed antivirals, including pharmaceutical kinase inhibitors, might help improve the drug qualities. Here, we focused on utilizing PROteolysis TArgeting Chimeras (PROTACs), i.e.,…

• Efficacy, Safety and Future Perspectives of JAK Inhibitors in the IBD Treatment - Although development of biologics has importantly improved the effectiveness in inducing and maintaining remission in inflammatory bowel disease (IBD), biologic therapies still have several limitations. Effective, low-cost drug therapy with good safety profile and compliance is therefore a substantial unmet medical need. A promising target for IBD treatment strategies are Janus kinase (JAK) inhibitors, which are small molecules that interact with cytokines implicated in pathogenesis of IBD. In…

• The Impact of COVID-19 Pandemic on Management and Outcome in Patients with Heart Failure - CONCLUSIONS: Mortality rates in HF patients infected with COVID-19 were high. The COVID-19 pandemic resulted in the reduced usage of health services but without increased overall mortality.

• Prevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19 - CONCLUSION: In patients admitted to the hospital for COVID-19, higher serum UA levels were independently associated with AKI, MAKE, and in-hospital mortality in a dose-dependent manner. In addition, hyperuricemia was associated with higher procalcitonin and troponin I levels.

• Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL(pro) inhibitors for treating COVID-19 - The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious therapeutics are urgently needed. 3-Chymotrypsin-like cysteine protease (3CL^(pro)) is an indispensable protein in viral replication and represents an attractive drug target for fighting COVID-19. Herein, we report the discovery of 9,10-dihydrophenanthrene derivatives as non-peptidomimetic and non-covalent inhibitors of the SARS-CoV-2…

• Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation - Avian infectious bronchitis (IB) was caused by infectious bronchitis virus (IBV), a coronavirus, which leads to enormous economic losses in the poultry industry. Studies have shown that lithium chloride (LiCl) is a good virus inhibitor. Through cell culture, virus infection, and RT-qPCR, we found that LiCl could down-regulate the apoptosis-related genes Caspase-3 and Bax, up-regulate Bcl-2, and down-regulate the inflammatory-related genes (NF-κB, NLRP3, TNF-α, and IL-1β) via inhibiting virus…

• Nanotilus: Generator of Immersive Guided-Tours in Crowded 3D Environments - Immersive virtual reality environments are gaining popularity for studying and exploring crowded three-dimensional structures. When reaching very high structural densities, the natural depiction of the scene produces impenetrable clutter and requires visibility and occlusion management strategies for exploration and orientation. Strategies developed to address the crowdedness in desktop applications, however, inhibit the feeling of immersion. They result in nonimmersive, desktop-style outside-in…

From Patent Search

• REAL-TIME REST BREAK MANAGEMENT SYSTEM FOR WORKPLACE - The present invention relates to a real-time rest break management system for workplace that comprises of a work desk, wherein first portion is incorporated with a biometric unit 4 for authenticating first user, and a second portion with a telescopic panel 2 associated with a weight sensor 6 and timer unit 7 calculating weight of head/hand manifesting user presence and their resting time period is mounted with an inflated cushion 5, an interactive primary display unit 1 attached over desk enables user to set first/second threshold time for sleeping/taking break, further linked with a tracking interface keeping track of activities and a vibrating unit crafted inside the cushion 5 which is linked to a secondary display unit 8 of second user, giving them access to actuate vibrating unit generating impulses to wake first user when threshold time period is exceeded by the first user. - link

• P2P 네트워크를 이용한 내장된 화상회의 시스템 - 본 발명은 P2P 네트워크를 이용한 내장된 화상회의 시스템에 관한 것으로, 상태표시부(1), 영상송출부(2), 제어부(3), 광고부(4), 입력부(5)를 포함한다. - link

• A DOORBELL SYSTEM FOR MONITORING AND RECORDING A PHYSIOLOGICAL DATA OF A PERSON - AbstractTitle: A doorbell system for monitoring and recording a physiological data of a person The present invention provides a doorbell system 500 for monitoring and recording a physiological data of a person. The doorbell system 500 having a transmitter module 100 and a receiving module 200. The transmitter module 100 is having a TOF sensor module 110, an ultrasound detector 120, and an infrared detector 130. Further, a speech recognition system 150, a facial recognition system 160, and a temperature detector 190 are provided for recognizing speech, face, and temperature of the person by comparing pre-stored data. A controlling module 180 is set with a predefined commands for communicating with the transmitter module 100 and receiving module 200. The collected facial and speech data is compared and matched with the pre-stored data then the temperature detector 190 triggers and the door opens when the captured body temperature of the person is matched within the predefined range of temperature.Figure 1 - link

• A study of contemporary trends in investing patterns, household savings, and economic investment. - Because household savings and household investments are intertwined and interdependent, they are discussed briefly in this paper. Household savings account for more than half of a country’s capital formation, which fluctuates due to a variety of economic factors such as inflation and interest rates. Households should gradually shift their savings and investments from physical assets to financial assets to avoid a sudden change in wealth. They should also save and invest using a variety of platforms. Trends in investing and saving will be easier to track and measure this way. This year’s domestic saving rate in India is 2.3 percent lower than last year’s and 1.2 percent lower than the year before. Since 2011, general domestic savings have been steadily declining, with the trend continuing into the following year. According to official data, the GDP in 2020 shrank by 23.9%, the least in previous years and the least since the Covid-19 pandemic in previous years. As a result, the information presented in this paper is drawn from and evaluated from other sources - link

• 靶向刺激体液免疫和细胞免疫的新冠病毒mRNA疫苗 - 本发明公开了一种靶向刺激体液免疫和细胞免疫的新冠病毒mRNA疫苗。本申请的第一方面提供一种分离的DNA分子组合，该DNA分子组合包括第一DNA分子和第二DNA分子和第三DNA分子中的至少一种。通过第一DNA分子以及第二DNA分子和/或第三DNA分子的组合，利用第一DNA分子最终合成的mRNA诱导高滴度的交叉中和抗体，利用第二DNA分子和/或第三DNA分子最终合成的mRNA诱导新冠病毒特异性的细胞毒性T淋巴细胞，从而高效地同时激活相对独立的体液免疫应答和细胞免疫应答，应对新冠病毒在流行传播过程中产生的突变毒株所引发的突破性感染。 - link

• 跨膜丝氨酸蛋白酶2抑制剂在制备治疗和/或预防冠状病毒感染药物中的用途 - 本发明公开了跨膜丝氨酸蛋白酶2抑制剂在制备治疗和/或预防冠状病毒感染药物中的用途。本发明通过亲和垂钓及活性导向分离获得3种化合物，证实该类化合物可以直接地与跨膜丝氨酸蛋白酶2结合，KD<13μM，且能够显著抑制跨膜丝氨酸蛋白酶2的催化活性。在细胞水平上可以有效的抑制新型冠状病毒SARS‑CoV‑2假病毒入侵，表明该类化合物对于制备治疗和/或预防病毒感染药物具有非常积极的作用。化合物1 化合物2 化合物3。 - link

• PROLIPOSOMAL DRY POWDER INHALER OF REMDESIVIR - The present invention is related to Proliposomal Dry Powder Inhaler of Remdesivir and its method thereof for the treatment of viral infections such Coronaviridae (including COVID-19 infection). - link

• Use of Diminazene Aceturate, Xanthenone, ACE 2 activators or analogs for the Treatment and therapeutic use of COVID-19 on human patients. - - link

• ACTIVE RIDER SAFETY SYSTEM FOR TWO WHEELERS - The present invention relates to an active rider safety system for two wheelers comprising, a protective case equipped by a user for riding, where the case is integrated with multiple piezoelectric sensor that determines fastening of the case by user, a processing unit linked to the sensor, where the unit detects absence of case upon fetching data from the sensor below a threshold value and thereby terminates operation of ignition by stopping a coupled motor operated via a radio frequency module, an alcohol detection sensor that detects presence of alcohol and send data to processing unit, a temperature sensor that measures temperature of the user, an accelerometer sensor that activates upon ignition us tuned on to determine presence of a crash and a navigation module that via communication module sends location of user to pre saved users and concerned authorities. - link

• Medizintechnische Haltevorrichtung und Haltevorrichtungs-Kit jeweils zum Halten von allgemeinmedizinischen, chirurgischen oder diagnostischen Einrichtungen oder Instrumenten sowie deren Verwendung insbesondere zur Datenerfassung -

  Medizintechnische Haltevorrichtung (10) eingerichtet zum Halten von allgemeinmedizinischen, chirurgischen oder diagnostischen Einrichtungen oder Instrumenten, insbesondere Diagnose-Einrichtungen oder -instrumenten für den Mund-/Rachenraum aus der folgenden Gruppe: Spatel (1), Abstrich-Einrichtung (2), Lichtquelle (3), Kamera (4); wobei die Haltevorrichtung (10) aufweist:

• einen Kontaktbereich (15) zum manuellen Kontaktieren der Haltevorrichtung (10) durch einen Nutzer;
• wenigstens eine mit dem Kontaktbereich (15) verbundene Haltekupplung (11, 12, 13) zum reversiblen Kuppeln, insbesondere form- und/oder kraftschlüssigen Kuppeln, der jeweiligen Einrichtung oder des Instruments; dadurch gekennzeichnet, dass der Kontaktbereich (15) eine Mindest-Längserstreckung (x15) von 20cm aufweist, wobei die wenigstens eine Haltekupplung (11, 12) an einem Längs-Ende des Kontaktbereichs (15) angeordnet ist, und wobei der Kontaktbereich

15. zumindest teilweise aus Kupfer besteht oder Kupfer als Oberflächenmaterial/-werkstoff aufweist, wobei die medizintechnische Haltevorrichtung (10) eingerichtet ist zum Kuppeln einer/der Kamera im Kontaktbereich, insbesondere bei Verwendung einer Kamera mit einem Gehäuse mit integrierter Kuppelfunktion.

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