Covid-19 Sentry

Contents

• From Preprints
• From Clinical Trials
• From PubMed
• From Patent Search

From Preprints

• Architecture Education During the Covid-19 Pandemic -
  Online learning, also known as e-learning, is the result of the evolution of distance learning that has developed following technological developments, especially information technology. Before the pandemic, online learning was only one alternative that enriched the learning process. Various courses are implemented by combining offline and online learning processes called blended learning. Through the Learning Management System (LMS), the Department of Architecture Unhas combines offline and online learning in studio-based design courses. Lecturers and students are trained to carry out the stages of the learning process guided by online procedures. The ongoing Covid-19 pandemic has made online learning the only way to keep the learning process going as planned. The sudden shift of studio-based courses from offline to totally online resulted in a change in the learning environment and experience. This study found that the online learning process is largely determined by the availability of learning materials and instruction in the LMS, the distance between learning space and time, the learning experience and the meaning of independent learning perceived by students. The study involved student participants at all semester levels, academic administration staff, lecturers, and student parents.
  🖺 Full Text HTML: Architecture Education During the Covid-19 Pandemic
• Indonesian Economic Policy Universal Basic Income During the Covid-19 Pandemic for National Defense -
  The impact of the COVID-19 pandemic has prompted the government to carry out social assistance programs. The purpose of this study is to analyze Universal Basic Income as a response to the COVID-19 pandemic which can simultaneously strengthen economic defenses in Indonesia as a form of peace dividends. This research uses the literature study method to previous relevant research strategy theory by identifying ends, ways, and means. The results of this study support universal basic income as a policy (ways) to deal with the crisis due to COVID-19 pandemic. UBI can provide an increase in Indonesia’s economic growth and empower Indonesian people to be better prepared to face risks, which will lead people to innovate more. UBI can also strengthen the defense economy in Indonesia because by reducing poverty, unemployment and social inequality, the crime rate caused by the economy will decrease, human resources will increase, and community relations will be stronger (ends). The resources (Means) needed to implement UBI in Indonesia are the budget, existing regulations, human resources (HR), and the latest Indonesia’s population data.
  🖺 Full Text HTML: Indonesian Economic Policy Universal Basic Income During the Covid-19 Pandemic for National Defense
• Willingness to Take the Booster Vaccine in a Nationally Representative Sample of Danes -
  We estimate the willingness to taking the booster dose in a representative sample of Danes. We estimate an overall willingness in the adult Danish population of 85.5 percent and a willingness of 94.7 percent among primary vaccine takers. We, moreover, show that these percentages will be significantly lower among younger populations as well as among groups who do not see COVID-19 as a threat towards society and who do not perceive the advice of the health authorities as effective against disease spread.
  🖺 Full Text HTML: Willingness to Take the Booster Vaccine in a Nationally Representative Sample of Danes
• Economic and Emotional Perceptions During and After COVID19 -
  Faced with the SARS-CoV-2pandemic, we decided to investigate if recovery from this large exogenous global shock depended on both emotional and economic recovery. We piloted a survey from May 2020 – August 2020 to examine how exposure to this global pandemic shaped economic outlook, and we documented the innate emotional styles of respondents. We then sought to answer two questions. Do the emotional style dimensions have anything to do with economic recovery? And are wages and emotional dimensions associated with economic outlook? With these questions in mind, we estimated two structural equation models. We jointly estimated all six emotional dimensions for the first question and assessed their impact on economic outlook. We estimated a structural model with a Mincer-wage equation and emotional outlook, resilience, and attention equations for the second question. We found that emotional outlook was positively and significantly correlated with economic outlook. We also found that wages, emotional- outlook, resilience, and attention were correlated with returning to behavior-normal, meaning once the public health crisis abates, fear will cease to restrict mobility in all sectors. We found pessimism over returning to business-normal, patronizing businesses that are significantly affected by the pandemic could have a dampening effect on economic recovery. However, this could be offset by the positive correlations between emotional outlook on economic outlook and returning to behavior-normal, both of which could boost economic recovery. From a public policy standpoint fostering a positive emotional outlook and encouraging emotional resilience could be the mojo needed for faster economic recovery.
  🖺 Full Text HTML: Economic and Emotional Perceptions During and After COVID19
• ‘Variant fatigue’? Public attitudes to COVID-19 18 months into the pandemic: A qualitative study -
  Objectives: Qualitative study exploring public attitudes to COVID-19 18 months into the pandemic, specifically focused on adherence to infection-reducing behaviours and policy measures during a period of the emergence of a new variant (Omicron) Study design: Qualitative online focus group study Methods: Focus groups were conducted with a diverse sample of 22 adults in the United Kingdom to explore their views. Data were analysed using a framework approach. Findings: Analysis revealed two main groups based on participants’ perceived concern over Omicron: variant fatigue (n=16 (73%)) and deja vu (n=6 (27%)). Those exhibiting variant fatigue reported not adopting any additional caution or infection-reducing behaviours as a result of the new variant. They tended to describe Omicron as ‘just another variant’ and expressed a need to ‘get on’ and ‘live with’ the virus. Those exhibiting deja vu suggested that Omicron was of additional concern to them and for some posed a threat not seen since ‘last year’ (second wave). No demographic patterns emerged, although there was a high amount of variant fatigue (absence of additional caution) (n=5 (83%)) amongst the unvaccinated participants. Those who were concerned about Omicron tended to report reducing social contacts. Few participants reported taking lateral flow tests regularly, except for those required to by their employers. Stated compliance with facemask rules was high. Nearly all participants stated an intention to comply with any future potential policy measures to reduce transmission of COVID-19, including more stringent measures such as lockdowns. Implications: 18 months into the pandemic, there may be habituation to the risk posed by COVID-19, despite the increased risk posed by the new variant Omicron. Due to this risk habituation (‘variant fatigue’) and due to a general decline in engagement with news related to COVID-19, many people may not be, or might be reluctant to, voluntarily adopt additional caution and infection-reducing behaviours. This poses a challenge for public health communication, since a sense of being ‘relaxed’ about, or ‘living with’ COVID-19 may undermine efforts to encourage voluntary adherence to infection-reducing behaviours. However, findings suggest that most people intend to comply (albeit reluctantly) with policy measures (as opposed to ‘advice’)- including stringent measures such as lockdown - if they were required in future.
  🖺 Full Text HTML: ‘Variant fatigue’? Public attitudes to COVID-19 18 months into the pandemic: A qualitative study
• Agreeableness and neuroticism predict being more concerned about COVID-19 and bothered by friends’ risky behavior -
  Given the importance of friendships during challenging times and the mixed associations reported between personality traits and disease-related behaviors, we investigated the influence of personality traits on friendships during the COVID-19 pandemic and how both influenced risky behaviors. In November 2020, we asked participants about their reactions to friends’ behavior as part of a larger study. We found that agreeableness and neuroticism predicted participants being more concerned about COVID-19 and bothered by friends’ risky behavior, and extraversion predicted enjoying helping friends during the pandemic. Our results suggest that personality influences how individuals cope with their friends’ risky behaviors. This work could be relevant for developing interventions to reduce risk taking during the pandemic, such as using friendships to reinforce adherence to public health guidelines.
  🖺 Full Text HTML: Agreeableness and neuroticism predict being more concerned about COVID-19 and bothered by friends’ risky behavior
• A Moderated Mediation Model of Self-Construal, Social Trust, and Compliance on Covid-19 Public Health Regulation: A Cross-country Analysis -
  To address the global Covid-19 pandemic, governments around the world require on the collective cooperation of their citizens to comply with public health regulation. Earlier studies examined the extent to which self-construal has an impact on individual compliance to law. However, existing literature has paid little significant attention to behavioural outcome of self-construal in the pandemic context across countries and cultures. The aim of this study was;

1. to determine whether interdependent self-construal predicts compliance of Covid-19 public health regulation, 2) to examine if the association was mediated by individual social trust, and 3) to test whether these associations were moderated by respondent’s country of residence (US x Indonesia). General adult respondents from US (N=231) and Indonesia (N=440) were voluntary participated in a survey measuring their trust to the government, interdependent self-construal orientation and compliance toward Covid-19 public health regulation. While our moderated mediation model involving respondent’s country residence did not support the hypothesis, the mediation analysis demonstrated significant association between interdependent self-construal and compliance via social trust. Our additional simple moderation analysis on direct effect of interdependent self-construal and compliance showed significant findings. Further, theoretical and practical implications of these findings were discussed in the following paper.
   🖺 Full Text HTML: A Moderated Mediation Model of Self-Construal, Social Trust, and Compliance on Covid-19 Public Health Regulation: A Cross- country Analysis

• Rapid COVID-19 Test: Investigating the Willingness to Take a Rapid Test Based on Multiple Factors -
  The COVID-19 Pandemic has had a significant impact on society. Due to the large lose of life, scientists have attempted to develop various rapid testing methods. Several methods have been developed among them, an inexpensive paper test. The researcher has endeavored to determine what factors will influence a person’s willing to take a daily covid-19 test. Via a survey instrument that was disseminated we received a response of N=546 participants. We performed many standard statistical tests, t-tests, and one way ANOVA’s as well as Chi Squared tests and Linear by linear associations. Via this analysis were able to determine that there is a statistical significance between willingness to take daily rapid covid-19 test (p <0.05 and, washing your hand (p <0.001), being cautious of your actions (p <0.001), being concerned about covid-19 (p <0.001) and preventing things before they happen (p <0.001). Risk averse people more likely to take preventative measures to take actions to protect themselves and others around them. The lack of basic knowledge regarding the replication of SAR-CoV-2, has led people to underestimate the rapid spread of the virus. Thus, people are coming in contact with others during the most virulent state of the virus.
  🖺 Full Text HTML: Rapid COVID-19 Test: Investigating the Willingness to Take a Rapid Test Based on Multiple Factors
• Epidemic prevention strategies for COVID-19 key populations -
  Abstract Backgroud: Since 2021, all outbreaks of COVID-19 within mainland China have been associated with imported cases from abroad. The outbreak in Putian, Fujian province, occurred without obvious loopholes in the implementation of epidemic prevention, indicating loopholes in the current epidemic prevention strategies in mainland China. The loopholes should be identified and the epidemic prevention strategies should be improved as soon as possible. Methods: Is there a need to further extend the medical observation period and community health surveillance period for key populations? Is there a need to increase the number of nucleic acid screenings? Is there a need to change the methods of extraction of nucleic acid screening samples? Is there a need to expand the scope of the population for routine epidemic prevention surveillance? The analysis of these questions would contribute to the improvement of the COVID-19 epidemic prevention strategies. Results: There are larger outbreaks following the current intensive isolation medical observation period and community health surveillance period, the phenomenon shows that the loopholes in the assessment of cross-infection risk and health surveillance in China’s current COVID-19 prevention and control strategies, especially during health surveillance after the entry of undetected infected individuals into the community when they emerge during isolation medical observation, and during health surveillance in the community for those who regain positive status after case cure. Conclusions: The key points to improve epidemic prevention strategies includ that a scientific and rational assessment around the mean incubation period, cross-infection risk, and surveillance efficiency of COVID-19, and updating routine epidemic prevention surveillance measures for key populations, recently cured patients of COVID-19, and immersion populations. Keywords: COVID-19, epidemic prevention strategy, incubation period, cross-infection
  🖺 Full Text HTML: Epidemic prevention strategies for COVID-19 key populations
• Coping with COVID: Risk and Resilience Factors for Mental Health in a German Representative Panel Study -
  Background: The COVID-19 pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n=6,684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors with changes in psychological distress (PD; measured via PHQ-4) from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 in 2020 (M=2.45) and 2021 (M=2.21) was elevated compared to 2019 (M=1.79). Several risk factors (catastrophizing, neuroticism, asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. Comparison to pre-pandemic data stress the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.
  🖺 Full Text HTML: Coping with COVID: Risk and Resilience Factors for Mental Health in a German Representative Panel Study
• Preprints & Pandemics: Interventions into the Dynamic Scholarly System of Scholarly Communication -
  The COVID-19 pandemic is an exemplar of how scholarly communication can change in response to external shocks, even as the scholarly knowledge ecosystem is evolving rapidly, and many argue that swift and fundamental interventions are needed. However, it is much easier to identify ongoing changes and emerging interventions than to understand their immediate and long term impacts. This is illustrated by comparing the approaches applied by the scientific community to understand public health risks and interventions with those applied by the scholarly communications community to the science of COVID-19. There are substantial disagreements over the short- and long- term benefits of most proposed approaches to changing the practice of science communication, and the lack of systematic, empirically-based research in this area makes these controversies difficult to resolve. We argue that the methodology of analysis and intervention developed within public health can be usefully applied to the science-of-science. Starting with the history of DDT application, we illustrate four ways complex human systems threaten reliable predictions and blunt ad-hoc interventions. We then show how these four threats apply lead to the last major intervention in scholarly publication – the article publishing charge based open access model – to yield surprising results. Finally, we outline how these four threats may affect the impact of preprint initiatives, and we identify approaches drawn from public health to mitigate these threats.
  🖺 Full Text HTML: Preprints & Pandemics: Interventions into the Dynamic Scholarly System of Scholarly Communication
• Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response -
  A damaging inflammatory response is strongly implicated in the pathogenesis of severe COVID-19 but mechanisms contributing to this response are unclear. In two prospective cohorts, early non-neutralizing, afucosylated, anti-SARS- CoV-2 IgG predicted progression from mild, to more severe COVID-19. In contrast to the antibody structures that predicted disease progression, antibodies that were elicited by mRNA SARS-CoV-2 vaccines were low in Fc afucosylation and enriched in sialylation, both modifications that reduce the inflammatory potential of IgG. To study the biology afucosylated IgG immune complexes, we developed an in vivo model which revealed that human IgG-Fc{gamma}R interactions can regulate inflammation in the lung. Afucosylated IgG immune complexes induced inflammatory cytokine production and robust infiltration of the lung by immune cells. By contrast, vaccine elicited IgG did not promote an inflammatory lung response. Here, we show that IgG-Fc{gamma}R interactions can regulate inflammation in the lung and define distinct lung activities associated with the IgG that predict severe COVID-19 and protection against SARS-CoV-2.
  🖺 Full Text HTML: Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response
• Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype -
  The mutational landscape of SARS-CoV-2 varies at both the dominant viral genome sequence and minor genomic variant population. An early change associated with transmissibility was the D614G substitution in the spike protein. This appeared to be accompanied by a P323L substitution in the viral polymerase (NSP12), but this latter change was not under strong selective pressure. Investigation of P323L/D614G changes in the human population showed rapid emergence during the containment phase and early surge phase of wave 1 in the UK. This rapid substitution was from minor genomic variants to become part of the dominant viral genome sequence. A rapid emergence of 323L but not 614G was observed in a non- human primate model of COVID-19 using a starting virus with P323 and D614 in the dominant genome sequence and 323L and 614G in the minor variant population. In cell culture, a recombinant virus with 323L in NSP12 had a larger plaque size than the same recombinant virus with P323. These data suggest that it may be possible to predict the emergence of a new variant based on tracking the distribution and frequency of minor variant genomes at a population level, rather than just focusing on providing information on the dominant viral genome sequence e.g., consensus level reporting. The ability to predict an emerging variant of SARS-CoV-2 in the global landscape may aid in the evaluation of medical countermeasures and non-pharmaceutical interventions.
  🖺 Full Text HTML: Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype
• Repurposing BCG Vaccine to Protect my Parents, Children, and my Family against COVID-19: A Real-life Experience. -
  A first global family report, how a physician & scientist safely and effectively repurposed the very safe, very old, very economic live attenuated BCG vaccine to protect against COVID-19 complications for immunocompetent children, adults and geriatric participants.
  🖺 Full Text HTML: Repurposing BCG Vaccine to Protect my Parents, Children, and my Family against COVID-19: A Real-life Experience.
• Impacts of the COVID-19 Pandemic on a Human Research Islet Program -
  Designated a pandemic in March 2020, the spread of severe acute respiratory syndrome virus 2 (SARS-CoV2), the virus responsible for coronavirus disease 2019 (COVID-19), led to new guidelines and restrictions being implemented for individuals, businesses, and societies in efforts to limit the impacts of COVID-19 on personal health and healthcare systems. Here we report the impacts of the COVID-19 pandemic on pancreas processing and islet isolation/distribution outcomes at the Alberta Diabetes Institute IsletCore, a facility specialising in the processing and distribution of human pancreatic islets for research. While the number of organs processed was significantly reduced, organ quality and the function of cellular outputs were minimally impacted during the pandemic when compared to an equivalent period immediately prior. Despite the maintained quality of isolated islets, recipient groups reported poorer feedback regarding the samples. Our findings suggest this is likely due to disrupted distribution which led to increased transit times to recipient labs, particularly those overseas. Thus, to improve overall outcomes in a climate of limited research islet supply, prioritization of tissue recipients based on likely tissue transit times may be needed.
  🖺 Full Text HTML: Impacts of the COVID-19 Pandemic on a Human Research Islet Program

From Clinical Trials

• Trial to Evaluate Nitazoxanide for Treatment of Mild COVID-19 in Subjects Not at High Risk of Severe Illness - Condition:   COVID-19
  Interventions:   Drug: Nitazoxanide;   Drug: Placebo;   Dietary Supplement: Vitamin Super-B Complex
  Sponsor:   Romark Laboratories L.C.
  Not yet recruiting

• Trial to Evaluate Nitazoxanide for Treatment of Mild or Moderate COVID-19 in Subjects at High Risk of Severe Illness - Condition:   COVID-19
  Interventions:   Drug: Nitazoxanide;   Dietary Supplement: Vitamin Super-B Complex;   Drug: Placebo;   Other: Standard of Care
  Sponsor:  
  Romark Laboratories L.C.
  Not yet recruiting

• A Safety, Tolerability, and Efficacy Study of IBI314 in Ambulatory Patients With COVID-19 - Condition:   COVID-19
  Interventions:   Biological: IBI314;   Other: Placebo
  Sponsor:   Innovent Biologics (Suzhou) Co. Ltd.
  Not yet recruiting

• Adrecizumab (HAM8101) to Improve Prognosis and Outcomes in COVID-19 Trial - Condition:   COVID-19
  Interventions:   Biological: Adrecizumab (HAM 8101);   Drug: Placebo
  Sponsor:   Universitätsklinikum Hamburg-Eppendorf
  Not yet recruiting

• Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19 - Condition:   COVID-19
  Interventions:   Drug: Belnacasan;   Drug: Placebo
  Sponsor:  
  MedStar Health
  Recruiting

• A Study Evaluating Tocilizumab in Pediatric Patients Hospitalized With COVID-19 - Condition:   COVID-19
  Intervention:   Drug: Tocilizumab
  Sponsor:   Hoffmann- La Roche
  Not yet recruiting

• Immunogenicity Study of the Covid-19 (Recombinante) Vaccine With a 4 or 8 Week Interval Between the First Doses. - Condition:   COVID-19
  Intervention:   Biological: Covid-19 (recombinante) vaccine
  Sponsor:   The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
  Active, not recruiting

• A Study to Evaluate Efficacy and Safety of the Combination of SCTA01 & SCTA01C in Outpatients With COVID-19 - Condition:   COVID-19
  Interventions:   Drug: SCTA01 and SCTA01C;   Drug: Placebo
  Sponsor:   Sinocelltech Ltd.
  Not yet recruiting

• Efficacy,Immunogenicity and Safety of COVID-19 Vaccine , Inactivated Booster Dose in Adults Aged 18 Years and Above - Condition:   COVID-19
  Interventions:   Biological: Medium-dosage COVID-19 Vaccine,Inactivated;   Biological: High-dosage COVID-19 Vaccine,Inactivated;   Biological: Placebo-comparator group
  Sponsor:  
  Sinovac Research and Development Co., Ltd.
  Not yet recruiting

• Safety and Immunogenicity Study of Booster Vaccination in Different Doses of COVID-19 Vaccine (Vero Cell),Inactivated for Prevention of COVID-19 - Condition:   COVID-19
  Interventions:   Biological: High-dosage of COVID-19 vaccine (Vero cell), Inactivated;   Biological: Medium-dose COVID-19 Vaccine(Vero Cell),Inactivated
  Sponsor:  
  Sinovac Research and Development Co., Ltd.
  Active, not recruiting

• Clinical Trial for Oral Formula of Vanillin and Wheat Germ Oil for Treatment of Mild and Moderate COVID-19 Viral Disease - Condition:   Mild-to-moderate COVID-19
  Intervention:   Drug: Oral Capsule
  Sponsors:  
  Alexandria University;   Assoc. Prof. Ayman Baeis;   Dr. Noha Alaa Eldine Hassan Hamdy;   Ph. Hanya Hesham Sweilam
  Recruiting

• Safety and Immunogenicity Study of Booster Vaccination With COVID-19 Vaccine (Vero Cell),Inactivated From Different Manufactures for Prevention of COVID-19 - Condition:   COVID-19
  Interventions:   Biological: Experimental vaccine 1;   Biological: Experimental vaccine 2;   Biological: Experimental vaccine 3
  Sponsor:  
  Sinovac Research and Development Co., Ltd.
  Not yet recruiting

• Combination Assessment Trial of COVID-19 Vaccines (COMBAT-COVID) - Condition:   COVID 19 Vaccine
  Interventions:   Biological: BIBP (CNBG, Sinopharm) WIV;   Biological: CanSinoBIO;   Biological: AstraZeneca ChAdOx
  Sponsors:  
  Aga Khan University Hospital, Pakistan;   Coalition for Epidemic Preparedness Innovations;   University of Oxford;   International Vaccine Institute;   Harvard Medical School (HMS and HSDM);   Chughtai Lab;   National Institute of Health, Pakistan
  Not yet recruiting

• Oral Neutralizing Antibody Booster for Post-vaccinated People With COVID19 Vaccine - Condition:   COVID-19 Pandemic
  Intervention:   Dietary Supplement: Bacillus subtilis spore extract
  Sponsors:   DreamTec Research Limited;   Hong Kong Metropolitan University;   DreamTec Cytokine Limited
  Recruiting

• Transplantation of Deceased Donors With COVID-19 Into COVID-19 Negative Recipients Utilizing Casirivimab and Imdevimab Antibody Cocktail - Conditions:   COVID-19;   Organ Transplant
  Intervention:  
  Drug: Casirivimab and Imdevimab Antibody Cocktail
  Sponsors:   Northwell Health;   Regeneron Pharmaceuticals
  Not yet recruiting

From PubMed

• Inhibiting TGF-[Formula: see text] 1-Mediated Cellular Processes as an Effective Strategy for the Treatment of Pulmonary Fibrosis with Chinese Herbal Medicines - Pulmonary fibrosis (PF) is a chronic and irreversible interstitial lung disease that even threatens the lives of some patients infected with COVID-19. PF is a multicellular pathological process, including the initial injuries of epithelial cells, recruitment of inflammatory cells, epithelial-mesenchymal transition, activation and differentiation of fibroblasts, etc. TGF-[Formula: see text]1 acts as a key effect factor that participates in these cellular processes of PF. Recently, much attention…

• Phytochemical rich Himalayan Rhododendron arboreum petals inhibit SARS-CoV-2 infection in vitro - Phytochemicals with potential to competitively bind to the host receptors or inhibit SARS-CoV-2 replication, may prove to be useful as adjunct therapeutics for COVID-19. We profiled and investigated the phytochemicals of Rhododendron arboreum petals sourced from Himalayan flora, undertook in vitro studies and found it as a promising candidate against SARS-CoV-2. The phytochemicals were reported in various scientific investigations to act against a range of virus in vitro and in vivo, which…

• Licorice (Glycyrrhiza glabra) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review - Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome…

• Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model - The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro. Herein, we examined the inhibitory effect of green tea polyphenols on coronavirus replication in a mouse model. We used epigallocatechin gallate (EGCG) and green tea polyphenols…

• Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro - Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, causes neonatal pig acute gastrointestinal infection with a characterization of severe diarrhea, vomiting, high morbidity, and high mortality, resulting in tremendous damages to the swine industry. Neither specific antiviral drugs nor effective vaccines are available, posing a high priority to screen antiviral drugs. The aim of this study is to investigate anti-PEDV effects of carbazole alkaloid derivatives. Eighteen carbazole…

• SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response - In the past year and a half, SARS-CoV-2 has caused 240 million confirmed cases and 5 million deaths worldwide. Autophagy is a conserved process that either promotes or inhibits viral infections. Although coronaviruses are known to utilize the transport of autophagy-dependent vesicles for the viral life cycle, the underlying autophagy-inducing mechanisms remain largely unexplored. Using several autophagy-deficient cell lines and autophagy inhibitors, we demonstrated that SARS-CoV-2 ORF3a was able…

• Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro - Epidemic RNA viruses seem to arise year after year leading to countless infections and devastating disease. SARS-CoV-2 is the most recent of these viruses, but there will undoubtedly be more to come. While effective SARS-CoV-2 vaccines are being deployed, one approach that is still missing is effective antivirals that can be used at the onset of infections and therefore prevent pandemics. Here, we screened FDA-approved compounds against SARS-CoV-2. We found that atovaquone, a pyrimidine…

• Soliris to Stop Immune-Mediated Death in COVID-19 (SOLID-C19)-A Compassionate-Use Study of Terminal Complement Blockade in Critically Ill Patients with COVID-19-Related Adult Respiratory Distress Syndrome - Eculizumab, a terminal complement (C5)-inhibiting monoclonal antibody, was administered in five mechanically ventilated patients in life-threatening condition due to COVID-19-related acute respiratory distress syndrome (ARDS) between 23 March 2020 and 3 April 2020. Their clinical progress was monitored. The primary endpoint was mortality. One patient was excluded while two passed away. The remaining two patients survived. At the time of this study, the mortality rate in mechanically ventilated…

• Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection - Murine hepatitis virus strain A59 (MHV-A59) was shown to induce pyroptosis, apoptosis, and necroptosis of infected cells, especially in the murine macrophages. However, whether ferroptosis, a recently identified form of lytic cell death, was involved in the pathogenicity of MHV-A59 is unknown. We utilized murine macrophages and a C57BL/6 mice intranasal infection model to address this. In primary macrophages, the ferroptosis inhibitor inhibited viral propagation, inflammatory cytokines released,…

• Hydroxypropyl Methylcellulose-Based Nasal Sprays Effectively Inhibit In Vitro SARS-CoV-2 Infection and Spread - The ongoing coronavirus disease (COVID-19) pandemic has required a variety of non-medical interventions to limit the transmission of the causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One such option is over-the-counter nasal sprays that aim to block virus entry and transmission within the nasal cavity. In this study, we assessed the ability of three hydroxypropyl methylcellulose (HPMC)-based powder nasal sprays, produced by Nasaleze, to inhibit SARS-CoV-2…

• Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA Assay - This protocol describes an ELISA-based procedure for accurate measurement of SARS-CoV-2 spike protein-receptor binding domain (RBD) neutralization efficacy by murine immune serum. The procedure requires a small amount of S-protein/RBD and angiotensin converting enzyme-2 (ACE2). A high-throughput, simple ELISA technique is employed. Plate-coated-RBDs are allowed to interact with the serum, then soluble ACE2 is added, followed by secondary antibodies and substrate. The key steps in this procedure…

• Serum Antibody Response Comparison and Adverse Reaction Analysis in Healthcare Workers Vaccinated with the BNT162b2 or ChAdOx1 COVID-19 Vaccine - The COVID-19 pandemic is changing rapidly and requires different strategies to maintain immunization. In Korea, different COVID-19 vaccines are recommended and available for various populations, including healthcare workers (HCWs) at high risk of SARS-CoV-2 infection. We plan to evaluate the adverse events (AEs) and immunogenicity of the BNT162b2 and ChAdOx1 vaccines in HCWs at a single center. This cohort study included HCWs fully vaccinated with either BNT162b2 or ChAdOx1. Blood samples were…

• Dracocephalum moldavica Ethanol Extract Suppresses LPS-Induced Inflammatory Responses through Inhibition of the JNK/ERK/NF-kappaB Signaling Pathway and IL-6 Production in RAW 264.7 Macrophages and in Endotoxic-Treated Mice - The excessive synthesis of interleukin-6 (IL-6) is related to cytokine storm in COVID-19 patients. Moreover, blocking IL-6 has been suggested as a treatment strategy for inflammatory diseases such as sepsis. Sepsis is a severe systemic inflammatory response syndrome with high mortality. In the present study, we investigated the anti-inflammatory and anti-septic effects and the underlying mechanisms of Dracocephalum moldavica ethanol extract (DMEE) on lipopolysaccharide (LPS)-induced inflammatory…

• Inhibition Ability of Natural Compounds on Receptor-Binding Domain of SARS-CoV2: An In Silico Approach - The lack of medication to treat COVID-19 is still an obstacle that needs to be addressed by all possible scientific approaches. It is essential to design newer drugs with varied approaches. A receptor-binding domain (RBD) is a key part of SARS-CoV-2 virus, located on its surface, that allows it to dock to ACE2 receptors present on human cells, which is followed by admission of virus into cells, and thus infection is triggered. Specific receptor-binding domains on the spike protein play a pivotal…

• Promising Antiviral Activity of Agrimonia pilosa Phytochemicals against Severe Acute Respiratory Syndrome Coronavirus 2 Supported with In Vivo Mice Study - The global emergence of the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has focused the entire world’s attention toward searching for a potential remedy for this disease. Thus, we investigated the antiviral activity of Agrimonia pilosa ethanol extract (APEE) against SARS-CoV-2 and it exhibited a potent antiviral activity with IC(50) of 1.1 ± 0.03 µg/mL. Its mechanism of action was elucidated, and it exhibited a virucidal activity and an inhibition of…

From Patent Search

• Hung Thanh Phan COVID-19 NEW SOLUTION - - link

• METHODS OF TREATING SARS-COV-2 INFECTION - - link

• REAL-TIME REST BREAK MANAGEMENT SYSTEM FOR WORKPLACE - The present invention relates to a real-time rest break management system for workplace that comprises of a work desk, wherein first portion is incorporated with a biometric unit 4 for authenticating first user, and a second portion with a telescopic panel 2 associated with a weight sensor 6 and timer unit 7 calculating weight of head/hand manifesting user presence and their resting time period is mounted with an inflated cushion 5, an interactive primary display unit 1 attached over desk enables user to set first/second threshold time for sleeping/taking break, further linked with a tracking interface keeping track of activities and a vibrating unit crafted inside the cushion 5 which is linked to a secondary display unit 8 of second user, giving them access to actuate vibrating unit generating impulses to wake first user when threshold time period is exceeded by the first user. - link

• P2P 네트워크를 이용한 내장된 화상회의 시스템 - 본 발명은 P2P 네트워크를 이용한 내장된 화상회의 시스템에 관한 것으로, 상태표시부(1), 영상송출부(2), 제어부(3), 광고부(4), 입력부(5)를 포함한다. - link

• 小分子化合物肌醇六磷酸酯钠水合物在制备抗SARS-CoV-2药物中的应用 - 本发明公开了小分子化合物肌醇六磷酸酯钠水合物在制备抗严重急性呼吸综合征冠状病毒2(SARS‑CoV‑2)药物中的应用，所述抗SARS‑CoV‑2药物是以肌醇六磷酸酯钠水合物为唯一的活性成份，或包含肌醇六磷酸酯钠水合物的药物组合物，所述抗SARS‑CoV‑2药物是指预防或治疗SARS‑CoV‑2感染的药物。本发明利用SARS‑CoV‑2的易感细胞系，包括非洲绿猴肾细胞Vero

E6以及人肺腺癌细胞Calu‑3，检测肌醇六磷酸酯钠水合物的抗SARS‑CoV‑2活性。实验结果显示，肌醇六磷酸酯钠水合物能有效抑制SARS‑CoV‑2对上述易感细胞的感染，且细胞毒性较小，有希望作为有效抗SARS‑CoV‑2感染的药物，具有应用前景。 - link

• A DOORBELL SYSTEM FOR MONITORING AND RECORDING A PHYSIOLOGICAL DATA OF A PERSON - AbstractTitle: A doorbell system for monitoring and recording a physiological data of a person The present invention provides a doorbell system 500 for monitoring and recording a physiological data of a person. The doorbell system 500 having a transmitter module 100 and a receiving module 200. The transmitter module 100 is having a TOF sensor module 110, an ultrasound detector 120, and an infrared detector 130. Further, a speech recognition system 150, a facial recognition system 160, and a temperature detector 190 are provided for recognizing speech, face, and temperature of the person by comparing pre-stored data. A controlling module 180 is set with a predefined commands for communicating with the transmitter module 100 and receiving module 200. The collected facial and speech data is compared and matched with the pre-stored data then the temperature detector 190 triggers and the door opens when the captured body temperature of the person is matched within the predefined range of temperature.Figure 1 - link

• Schnelltestsystem -

  Schnelltestsystem, aufweisend: eine Testkassette (11), die ein Testfeld (111) und einen einem bestimmten Benutzer entsprechenden Identifikationsstrichcode (113) aufweist, wobei das Testfeld (111) eine Probe (115) empfängt, um eine Testreaktion (R) zu bewirken, wodurch sich ein der Testreaktion (R) entsprechendes Muster (G) ergibt; und ein tragbares elektronisches Gerät (13), das eine Bildaufnahmeeinheit (131) aufweist, wobei die Bildaufnahmeeinheit (131) das Muster

7. und den Identifikationsstrichcode (113) liest und anschließend an einen Server (15) sendet.

• link

• A study of contemporary trends in investing patterns, household savings, and economic investment. - Because household savings and household investments are intertwined and interdependent, they are discussed briefly in this paper. Household savings account for more than half of a country’s capital formation, which fluctuates due to a variety of economic factors such as inflation and interest rates. Households should gradually shift their savings and investments from physical assets to financial assets to avoid a sudden change in wealth. They should also save and invest using a variety of platforms. Trends in investing and saving will be easier to track and measure this way. This year’s domestic saving rate in India is 2.3 percent lower than last year’s and 1.2 percent lower than the year before. Since 2011, general domestic savings have been steadily declining, with the trend continuing into the following year. According to official data, the GDP in 2020 shrank by 23.9%, the least in previous years and the least since the Covid-19 pandemic in previous years. As a result, the information presented in this paper is drawn from and evaluated from other sources - link

• 靶向刺激体液免疫和细胞免疫的新冠病毒mRNA疫苗 - 本发明公开了一种靶向刺激体液免疫和细胞免疫的新冠病毒mRNA疫苗。本申请的第一方面提供一种分离的DNA分子组合，该DNA分子组合包括第一DNA分子和第二DNA分子和第三DNA分子中的至少一种。通过第一DNA分子以及第二DNA分子和/或第三DNA分子的组合，利用第一DNA分子最终合成的mRNA诱导高滴度的交叉中和抗体，利用第二DNA分子和/或第三DNA分子最终合成的mRNA诱导新冠病毒特异性的细胞毒性T淋巴细胞，从而高效地同时激活相对独立的体液免疫应答和细胞免疫应答，应对新冠病毒在流行传播过程中产生的突变毒株所引发的突破性感染。 - link

• 跨膜丝氨酸蛋白酶2抑制剂在制备治疗和/或预防冠状病毒感染药物中的用途 - 本发明公开了跨膜丝氨酸蛋白酶2抑制剂在制备治疗和/或预防冠状病毒感染药物中的用途。本发明通过亲和垂钓及活性导向分离获得3种化合物，证实该类化合物可以直接地与跨膜丝氨酸蛋白酶2结合，KD<13μM，且能够显著抑制跨膜丝氨酸蛋白酶2的催化活性。在细胞水平上可以有效的抑制新型冠状病毒SARS‑CoV‑2假病毒入侵，表明该类化合物对于制备治疗和/或预防病毒感染药物具有非常积极的作用。化合物1 化合物2 化合物3。 - link