Covid-19 Sentry

Contents

• From Preprints
• From Clinical Trials
• From PubMed
• From Patent Search

From Preprints

• A Perspective on Mature Gratitude as a Way of Coping with COVID-19 -
  Aim and Method: This perspective searches presents evidence of mature gratitude as a way of coping with the threats and boundaries of COVID-19. This narrative, non-systematic review will be based on studies from the COVID-19 period in association with more general literature on the characteristics of mature gratitude related to good mental health. Results: The results from the literature suggest that a confrontation with our existential vulnerability during a pandemic is not only a crisis but also an opportunity to view our lives in a different way. Mature gratitude, as proposed in this perspective, can help us in coping with the threats and boundaries that are part of our lives due to the COVID-19 pandemic. This time of crisis gives us the opportunity to self-reflect on our current life and plans for the future and to reframe them through a positive lens which can encourage individuals to actively strengthen their psychological resilience and coping skills. Conclusion: Cultivating an attitude of mature gratitude through actions of kindness, expressing being thankful for life and God, and enjoying all the small things in life helps in coping with the current threats of COVID-19 and building lifelong resilience for the future Knowledge about these associations can help psychologists, counselors, and coaches to support people who experience psychological issues due to the current pandemic and all crises to come.
  🖺 Full Text HTML: A Perspective on Mature Gratitude as a Way of Coping with COVID-19
• Temporal Distancing during the COVID-19 pandemic: Letter Writing with Future Self can Mitigate Negative Affect -
  Novel coronavirus disease (COVID-19) is spreading across the world, threatening not only physical health but also psychological well-being. We reasoned that a broadened temporal perspective may attenuate current mental distress and tested a letter-writing manipulation designed to connect people to their post-COVID-19 future selves. Participants were randomly assigned to either send a letter to their future self (letter-to-future), send a letter to present self from the perspective of future self (letter-from-future), or a control condition. Participants in both letter-writing conditions showed immediate decrease in negative affect and increase in positive affect relative to the control condition. These effects were mediated by temporal distancing from the current situation. These findings suggest that taking a broader temporal perspective can be achieved by letter-writing with a future self and may offer an effective means of regulating negative affect in a stressful present time such as the COVID-19 pandemic.
  🖺 Full Text HTML: Temporal Distancing during the COVID-19 pandemic: Letter Writing with Future Self can Mitigate Negative Affect
• Negative shocks predict change in cognitive function and preferences: Assessing the negative affect and stress hypothesis in the context of the COVID-19 crisis -
  In the context of the current COVID-19 pandemic, households throughout the world have to cope with negative shocks, either because of the disease or the various mitigation strategies that have caused massive unemployment and financial insecurity. Previous research has shown that negative shocks impair cognitive function and change risk, time and social preferences. In this study, we analyze the results of a longitudinal multi-country survey conducted in Italy (N=1,652), Spain (N=1,660) and the United Kingdom (N=1,578). We measure cognitive function using the Cognitive Reflection Test and preferences traits using an experimentally validated set of questions to assess the differences between people exposed to a shock compared to the rest of the sample. We measure four possible types of shocks: labor market shock, health shock, occurrence of stressful events, and mental health shock. Additionally, we randomly assign participants to groups with either a recall of negative events (more specifically, a mild reinforcement of stress or of fear/anxiety), or to a control group (to recall neutral or joyful memories), in order to assess whether or not stress and negative emotions drive a change in preferences. Results show that people affected by shocks performed worse in terms of cognitive functioning, are more risk loving, and are more prone to punish others (negative reciprocity). Data do not support the hypotheses that the result is driven by stress or by negative emotions.
  🖺 Full Text HTML: Negative shocks predict change in cognitive function and preferences: Assessing the negative affect and stress hypothesis in the context of the COVID-19 crisis
• Assessment supervision during COVID-19 and beyond: Trainee perspectives on the supervision of teleassessment -
  Due to COVID-19, there has been a rapid shift toward the remote administration of psychological assessments, or teleassessment. Guidelines have been published by the American Psychological Association regarding best practices for teleassessment administration, yet there is limited guidance for the clinical supervision of trainees. Quality supervision is a core competency of health service psychologists, and critical to the professional development of practitioners, as well as the protection of patients. This article reviews the extant literature on teleassessment and makes practice-informed recommendations to enhance the supervision of teleassessment administration. Implications for training in teleassessment during the COVID-19 pandemic as well as the development of clinical training competencies in teleassessment are considered.
  🖺 Full Text HTML: Assessment supervision during COVID-19 and beyond: Trainee perspectives on the supervision of teleassessment
• A systematic review on sex- and gender-sensitive research in public mental health during the first wave of the COVID-19 crisis -
  Background Sex and gender are important modifiers of mental health and behavior in normal times and during crises. We investigated whether they were addressed by empirical, international research which explored the mental health and health behavior ramifications after the onset of the COVID-19 pandemic. Methods We systematically searched the databases PsyArXiv, PubMed, PsycInfo, Psyndex, PubPsych, Cochrane Library, and Web of Science for studies assessing mental health outcomes (main outcomes) as well as potential risk and protective health behavior (additional outcomes) up to July 2, 2020. Findings Most of the 80 publications fulfilling the selection criteria reflected the static difference perspective treating sex and gender as dichotomous variables. The focus was on internalizing disorders (esp. anxiety and depression) burdening women in particular, while externalizing disorders were neglected. Sex- and gender-specific evaluation of mental health care use has also been lacking. With respect to unfavorable health behavior in terms of adherence to prescribed protective measures, men constitute a risk group. Interpretations Women remain a vulnerable group burdened by multiple stresses and mental health symptoms. The neglect of sex and gender-specific evaluation of aggression-related disorders, substance addiction, and mental health care use in the early stage represents a potentially dangerous oversight.
  🖺 Full Text HTML: A systematic review on sex- and gender-sensitive research in public mental health during the first wave of the COVID-19 crisis
• Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19 -

  Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but there are limited data on incidence rates and relative risks. Methods. Using retrospective cohort studies and time-to-event analysis, we estimated the incidence of ICD-10 diagnoses in the 6 months after a confirmed diagnosis of COVID-19: intracranial haemorrhage; ischaemic stroke; Parkinsonism; Guillain-Barre syndrome; nerve/nerve root/plexus disorders; myoneural/muscle disease; encephalitis; dementia; mood, anxiety, and psychotic disorders; substance misuse; and insomnia. Data were obtained from the TriNetX electronic health records network (over 81 million patients). We compared incidences with those in propensity score-matched cohorts of patients with influenza or other respiratory infections using a Cox model. We investigated the effect on incidence estimates of COVID-19 severity, as proxied by hospitalization and encephalopathy (including delirium and related disorders). Findings. 236,379 patients survived a confirmed diagnosis of COVID-19. Among them, the estimated incidence of neurological or psychiatric sequelae at 6 months was 33.6%, with 12.8% receiving their first such diagnosis. Most diagnostic categories were commoner after COVID-19 than after influenza or other respiratory infections (hazard ratios from 1.21 to 5.28), including stroke, intracranial haemorrhage, dementia, and psychotic disorders. Findings were equivocal for Parkinsonism and Guillain-Barre syndrome. Amongst COVID-19 cases, incidences and hazard ratios for most disorders were higher in patients who had been hospitalized, and markedly so in those who had experienced encephalopathy. Results were robust to sensitivity analyses, including comparisons against an additional four index health events. Interpretation. The study provides evidence for substantial neurological and psychiatric morbidity following COVID-19 infection. Risks were greatest in, but not limited to, those who had severe COVID-19. The information can help in service planning and identification of research priorities.

  🖺 Full Text HTML: Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
• Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant -
  Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide and massive societal and economic burden. Recently, a new variant of SARS-CoV-2, known as B.1.1.7, was first detected in the United Kingdom and is spreading in several other countries, heightening public health concern and raising questions as to the resulting effectiveness of vaccines and therapeutic interventions. We and others previously identified host-directed therapies with antiviral efficacy against SARS-CoV-2 infection. Less prone to the development of therapy resistance, host-directed drugs represent promising therapeutic options to combat emerging viral variants as host genes possess a lower propensity to mutate compared to viral genes. Here, in the first study of the full-length B.1.1.7 variant virus, we find two host-directed drugs, plitidepsin (aplidin; inhibits translation elongation factor eEF1A) and ralimetinib (inhibits p38 MAP kinase cascade), as well as remdesivir, to possess similar antiviral activity against both the early-lineage SARS-CoV-2 and the B.1.1.7 variant, evaluated in both human gastrointestinal and lung epithelial cell lines. We find that plitidepsin is over an order of magnitude more potent than remdesivir against both viruses. These results highlight the importance of continued development of host-directed therapeutics to combat current and future coronavirus variant outbreaks.
  🖺 Full Text HTML: Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant
• An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19 -
  COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells. DS-autoAg complexes are capable of stimulating autoreactive B cells and autoantibody production. Using DS affinity, we identified an autoantigenome of 408 proteins from human fetal lung fibroblast HFL11 cells, at least 231 of which are known autoAgs. Comparing with available COVID data, 352 proteins of the autoantigenome have thus far been found to be altered at protein or RNA levels in SARS-Cov-2 infection, 210 of which are known autoAgs. The COVID-altered proteins are significantly associated with RNA metabolism, translation, vesicles and vesicle transport, cell death, supramolecular fibrils, cytoskeleton, extracellular matrix, and interleukin signaling. They offer clues to neurological problems, fibrosis, smooth muscle dysfunction, and thrombosis. In particular, 150 altered proteins are related to the nervous system, including axon, myelin sheath, neuron projection, neuronal cell body, and olfactory bulb. An association with the melanosome is also identified. The findings from our study illustrate a strong connection between viral infection and autoimmunity. The vast number of COVID-altered proteins with propensity to become autoAgs offers an explanation for the diverse autoimmune complications in COVID patients. The variety of autoAgs related to mRNA metabolism, translation, and vesicles raises concerns about potential adverse effects of mRNA vaccines. The COVID autoantigen atlas we are establishing provides a detailed molecular map for further investigation of autoimmune sequelae of the pandemic.
  🖺 Full Text HTML: An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19
• Meta-analysis reveals consistent immune response patterns in COVID-19 infected patients at single-cell resolution -
  A number of single-cell RNA studies looking at the human immune response to the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recently published. However, the number of samples used in each individual study typically is small, moreover the technologies and protocols used in different studies vary, thus somewhat restricting the range of conclusions that can be made with high confidence. To better capture the cellular gene expression changes upon SARS-CoV-2 infection at different levels and stages of disease severity and to minimise the effect of technical artefacts, we performed meta-analysis of data from 9 previously published studies, together comprising 143 human samples, and a set of 16 healthy control samples (10X). In particular, we used generally accepted immune cell markers to discern specific cell subtypes and to look at the changes of the cell proportion over different disease stages and their consistency across the studies. While half of the observations reported in the individual studies can be confirmed across multiple studies, half of the results seem to be less conclusive. In particular, we show that the differentially expressed genes consistently point to upregulation of type I Interferon signal pathway and downregulation of the mitochondrial genes, alongside several other reproducibly consistent changes. We also confirm the presence of expanded B-cell clones in COVID-19 patients, however, no consistent trend in T-cell clonal expansion was observed.
  🖺 Full Text HTML: Meta-analysis reveals consistent immune response patterns in COVID-19 infected patients at single-cell resolution
• Variation analysis of SARS-CoV-2 complete sequences from Iran -
  The SARS-CoV-2 is a new emerging coronavirus initially reported in China in late December 2019 and rapidly spread to the whole of the world. To date, 1261903 total cases and 55830 deaths are reported from Iran as of 8 January. In this study, we investigated all the complete sequences of SARS-CoV-2 that publicly reported from Iran. Twenty-four sequences between March to September 2020 were analyzed to identify genome variations and phylogenetic relationships. Furthermore, we assessed the amino acid changes related to the spike glycoprotein as an important viral factor associated with the entry to the host cells and as a vaccine target. Most of the variations occur in the ORF1ab, S, N, intergenic, and ORF7 regions. The analysis of spike protein mutations demonstrated that the D614G mutation could be detected from May and beyond. Phylogenetic analysis showed that most of the circulated viruses in Iran are belong to the B.4 lineage. Although, we found a limited number of variants associated with the B.1 lineage carrying D614G mutation. Furthermore, we detected a variant characterize as the B.1.36 lineage with sixteen mutations in the spike protein region. This study showed the frequency of the viral populations in Iran as of September, therefore, there is an emergent need for genomic surveillance to track viral lineage shift in the country beyond September. These data would help to predict the future situation and apply better strategies to control the pandemic.
  🖺 Full Text HTML: Variation analysis of SARS-CoV-2 complete sequences from Iran
• GIS-Based Analysis Framework for Identifying COVID-19 Incidence and Fatality Determinants at National Level Case study: Africa -

  Abstract Background: COVID-19 pandemic is an extraordinary threat with significant implications in all aspects of human life, therefore, it represents the most immediate challenges for all countries all over the world. Objectives: This study is intended to develop a GIS-based analysis model to explore, quantify and model the relationships between COVID-19 morbidity and mortality and their potential predictor variables. Method: For this purpose, a model was developed to estimate COVID-19 incidence and fatality rates in Africa up to 16th of August 2020 at the national level. The model involved Ordinary Least Squares (OLS) and Geographically Weighted Regression (GWR) analysis through ArcGIS was applied. Result: Spatial Autocorrelation Analysis revealed that there was positive spatial autocorrelation in COVID-19 incidence (Moran index 0.16. P value <0.1), and fatality (Moran index 0.0.35, P value<0.01) rates within different African countries. At continental level, OLS revealed that COVID-19 incidence rate was found to be positively associated with overcrowding, health expenditure, HIV infections and air pollution and negatively associated with BCG vaccine (β=2.97,1.45, 0.01, 3.29, -47.65 respectively, P< 0.05) At the same time, COVID-19 fatality was found to be positively related to asthma prevalence and tobacco use. Yet, certain level of inconsistency was noted in the case of COVID-19 fatality, which was negatively related to elder population, poverty, and cardiovascular mortality (P<0.05). This model showed convenient level of validity in modeling the relationship between COVID-19 incidence as well as fatality and their key predictors using GWR. In this respect, the model explained about 58% and 55% of the variance in COVID-19 incidence and fatality rates, respectively, as a function of considered predictors. Conclusion: Application of the suggested model can assist in guiding intervention strategies, particularly in case of local and community level whenever the data on COVID-19 cases and predictors variables are available.

  🖺 Full Text HTML: GIS-Based Analysis Framework for Identifying COVID-19 Incidence and Fatality Determinants at National Level Case study: Africa
• Determinants of COVID-19 Incidence and Mortality in the US: Spatial Analysis -

  OBJECTIVES: The US continues to account for the highest proportion of the global Coronavirus Disease-2019 (COVID-19) cases and deaths. Currently, it is important to contextualize the spread and success of mitigation efforts. The objective of this study was to assess the ecological determinants (policy, health behaviors, socio-economic, physical environment, and clinical care) of COVID-19 incidence and mortality in the US. METHODS: Data from the New York Times COVID-19 repository (01/21/2020-10/27/2020), 2020 County Health Rankings, 2016 County Presidential Election Returns, and 2018-2019 Area Health Resource File were used. County-level logged incidence and mortality rate/million were modeled using the Spatial Autoregressive Combined model and spatial lag model. RESULTS: Counties with higher proportions of racial minorities (African American β= 0.007, Native Americans β= 0.008, Hispanics β= 0.015), non-English speakers (β= 0.010), population density ([logged] β= 0.028), and air pollution (β= 0.062) were significantly associated with high COVID-19 incidence rates. Subsequently, counties with higher Republican voters (β= 0.017), excessive drinkers (β= 0.107), children in single-parent households (β= 0.018), uninsured adults (β= 0.038), racial minorities (African American β= 0.032, Native Americans β= 0.034, Hispanics β= 0.037), females (β= 0.101), and population density ([logged] β= 0.270), air pollution (β= 0.130), and non-Whites/Whites residential segregation (β= 0.014) were significantly associated with high COVID-19 mortality rates. Additionally, longer state-level restrictions were associated with lower COVID-19 incidence and mortality rates. CONCLUSION: The spatial models identified longer state-level restrictions, population density, air pollution, uninsured rate, and race/ethnicity as important determinants of the geographic disparities in COVID-19 incidence and mortality.

  🖺 Full Text HTML: Determinants of COVID-19 Incidence and Mortality in the US: Spatial Analysis
• In silico investigation of the new UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 variants with a focus at the ACE2-Spike RBD interface -
  SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have higher transmission capabilities, eventually due to amino acid substitutions on the SARS-CoV-2 Spike protein. The pathogenicity seems modified but is still under investigation. Here we used the experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor and several in silico methods to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) with regard to ACE2 binding. We found that the N501Y replacement in this region of the interface (present in both UK and South African strains) should be favorable for the interaction with ACE2 while the K417N and E484K substitutions (South African) would seem unfavorable. It is unclear if the N501Y substitution in the South African strain could counterbalance the predicted less favorable (regarding binding) K417N and E484K Spike replacements. Our finding suggests that, if indeed the South African strain has a high transmission level, this could be due to the N501Y replacement and/or to substitutions in regions outside the direct Spike-ACE2 interface.
  🖺 Full Text HTML: In silico investigation of the new UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 variants with a focus at the ACE2-Spike RBD interface
• Tool for estimating the probability of having COVID-19 with one or more negative RT-PCR results -

  Early case detection and isolation of infected individuals are critical to controlling COVID-19. RT-PCR is considered the diagnosis gold standard, but false-negatives occur. Based on previous work, we built a user-friendly online tool to estimate the probability of having COVID-19 with negative RT-PCR results and thus avoid preventable SARS-CoV-2 transmission.

  🖺 Full Text HTML: Tool for estimating the probability of having COVID-19 with one or more negative RT-PCR results
• Artificial Intelligence for Emotion-Semantic Trending and People Emotion Detection During COVID-19 Social Isolation -

  Taking advantage of social media platforms, such as Twitter, this paper provides an effective framework for emotion detection among those who are quarantined. Early detection of emotional feelings and their trends help implement timely intervention strategies. Given the limitations of medical diagnosis of early emotional change signs during the quarantine period, artificial intelligence models provide effective mechanisms in uncovering early signs, symptoms and escalating trends. Novelty of the approach presented herein is a multitask methodological framework of text data processing, implemented as a pipeline for meaningful emotion detection and analysis, based on the Plutchik/Ekman approach to emotion detection and trend detection. We present an evaluation of the framework and a pilot system. Results of confirm the effectiveness of the proposed framework for topic trends and emotion detection of COVID-19 tweets. Our findings revealed Stay-At-Home restrictions result in people expressing on twitter both negative and positive emotional semantics. Semantic trends of safety issues related to staying at home rapidly decreased within the 28 days and also negative feelings related to friends dying and quarantined life increased in some days. These findings have potential to impact public health policy decisions through monitoring trends of emotional feelings of those who are quarantined. The framework presented here has potential to assist in such monitoring by using as an online emotion detection tool kit.

  🖺 Full Text HTML: Artificial Intelligence for Emotion-Semantic Trending and People Emotion Detection During COVID-19 Social Isolation

From Clinical Trials

• Dexamethasone for COVID-19 - Condition:   Covid19
  Intervention:   Drug: Dexamethasone
  Sponsor:   University of Oklahoma
  Not yet recruiting

• Fluvoxamine Administration in Moderate SARS-CoV-2 (COVID-19) Infected Patients - Condition:   Covid19
  Interventions:   Drug: Placebo;   Drug: Fluvoxamine
  Sponsor:   SigmaDrugs Research Ltd.
  Recruiting

• APT™ T3X on the COVID-19 Contamination Rate - Condition:   COVID-19
  Interventions:   Drug: Tetracycline hydrochloride 3%;   Drug: Placebo
  Sponsors:   University of Nove de Julho;   Santa Casa de Misericórdia de Porto Alegre
  Not yet recruiting

• The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial) - Condition:   Covid19
  Interventions:   Drug: Ivermectin 0.6mg/kg/day;   Drug: Ivermectin 1.0mg/kg/day;   Drug: Placebo;   Drug: Hydroxychloroquine
  Sponsor:   Corpometria Institute
  Not yet recruiting

• A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia - Condition:   COVID-19
  Interventions:   Drug: ORTD-1 low dose;   Drug: ORTD-1 mid dose;   Drug: ORTD-1 high dose;   Other: Vehicle control
  Sponsor:   Oryn Therapeutics, LLC
  Recruiting

• Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air - Condition:   Covid19
  Intervention:   Diagnostic Test: Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process
  Sponsor:   Hospices Civils de Lyon
  Not yet recruiting

• COVID-19 Immunologic Antiviral Therapy With Omalizumab - Condition:   Covid19
  Interventions:   Biological: Omalizumab;   Other: Placebo
  Sponsor:   McGill University Health Centre/Research Institute of the McGill University Health Centre
  Not yet recruiting

• IMUNOR® Preparation in the Prevention of COVID-19 - Condition:   Covid19
  Intervention:   Drug: IMUNOR
  Sponsor:   University Hospital Ostrava
  Not yet recruiting

• Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19 - Condition:   COVID-19
  Interventions:   Drug: Doxycycline Tablets;   Drug: Rivaroxaban 15Mg Tab;   Combination Product: Hydroxychloroquine and Azithromycin
  Sponsor:   Yaounde Central Hospital
  Recruiting

• Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19 - Condition:   Covid19
  Interventions:   Drug: Vitamin C 500 MG Oral Tablet;   Drug: Tenofovir disoproxyl fumarate 300 MG Oral Tablet;   Drug: Tenofovir disoproxyl fumarate 300 MG plus emtricitabine 200 MG Oral Tablet
  Sponsors:   Universidade Federal do Ceara;   Conselho Nacional de Desenvolvimento Científico e Tecnológico;   São José Hospital for Infectious Diseases - HSJ;   Central Laboratory of Public Health of Ceará - Lacen-CE
  Recruiting

• A Phase Ⅱb Clinical Trial of Recombinant Corona Virus Disease-19 (COVID-19) Vaccine (Sf9 Cells) - Condition:   COVID-19
  Interventions:   Biological: Recombinant COVID-19 vaccine (Sf9 cells);   Biological: Placebo
  Sponsors:   Jiangsu Province Centers for Disease Control and Prevention;   West China Hospital
  Not yet recruiting

• Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Participants ≥ 60 Years of Age and Hospitalized With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure - Condition:   Covid19
  Interventions:   Drug: BGE-175;   Other: Placebo
  Sponsor:   BioAge Labs, Inc.
  Not yet recruiting

• Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients - Condition:   Covid19
  Interventions:   Drug: Betadine© bucal 100 mg/ml;   Drug: Oximen® 3%;   Drug: Clorhexidine Dental PHB©;   Drug: Vitis Xtra Forte©;   Drug: Distilled Water
  Sponsors:   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   Hospital Universitario Fundación Jiménez Díaz;   Hospital Universitario General de Villalba;   Hospital Universitario Infanta Elena;   Hospital Universitario Virgen de la Arrixaca;   Hospital Clínico Universitario de Valencia;   Dentaid SL
  Completed

• Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia - Condition:   COVID-19 Pneumonia
  Intervention:   Drug: Cefditoren pivoxil 400mg
  Sponsor:   Meiji Pharma Spain S.A.
  Recruiting

• Early Use of Hyperimmune Plasma in COVID-19 - Condition:   Covid19
  Intervention:   Other: hyperimmune plasma
  Sponsors:   Catherine Klersy;   Policlinico San Matteo Pavia Fondazione IRCCS
  Recruiting

From PubMed

• Can limonene be a possible candidate for evaluation as an agent or adjuvant against infection, immunity, and inflammation in COVID-19? - Coronavirus disease (COVID-19) caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite the tremendous social preventive measures. The therapeutic strategy relies on suppressing infectivity and inflammation, along with immune modulation. The identification of candidate drugs effective for COVID-19 is crucial, thus many natural products...

• Molecular Docking and Molecular Dynamics Aided Virtual Search of OliveNet Directory for Secoiridoids to Combat SARS-CoV-2 Infection and Associated Hyperinflammatory Responses - Molecular docking and molecular dynamics aided virtual search of OliveNet™ directory identified potential secoiridoids that combat SARS-CoV-2 entry, replication, and associated hyperinflammatory responses. OliveNet™ is an active directory of phytochemicals obtained from different parts of the olive tree, Olea europaea (Oleaceae). Olive oil, olive fruits containing phenolics, known for their health benefits, are indispensable in the Mediterranean and Arabian diets. Secoiridoids is the largest...

• Perspectives: potential therapeutic approach with inhalation of ACE2-derived peptides for SARS-CoV-2 infection - CONCLUSION: ACE2-derived peptides may play a dual beneficial role in COVID-19, by either preventing virus spread or inhibiting the secretion of pro-inflammatory mediators in airways. Viral, host, and environmental factors may affect the effectiveness of this therapeutic approach to a various extent and represent therefore a matter of investigation for future studies.

• Immunology, immunopathogenesis and immunotherapeutics of COVID-19; an overview - Coronavirus disease 2019 (COVID-19) infection which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a "public health emergency of international concern" (PHEIC). The infection is highly contagious, has a high mortality rate, and its pathophysiology remains poorly understood. Pulmonary inflammation with substantial lung damage together with generalized immune dysregulation are major components of COVID-19 pathogenesis. The former component, lung damage, seems...

• Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic - The global spread of COVID-19 constitutes the most dangerous pandemic to emerge during the last one hundred years. About seventy-nine million infections and more than 1.7 million death have been reported to date, along with destruction of the global economy. With the uncertainty evolved by alarming level of genome mutations, coupled with likelihood of generating only a short lived immune response by the vaccine injections, the identification of antiviral drugs for direct therapy is the need of...

• The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2 - The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in December 2019, subsequently its abrupt spread across the world has severely affected human life. In a short span of time, COVID-19 has sacked more than one million human lives and marked as a severe global pandemic, which is drastically accountable for the adverse effect directly to the human society, particularly the health care system...

• Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts - CONCLUSIONS: As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection. The "Chinese protocol" has already demonstrated clear clinical importance. The use of Chinese herbal medicines that are capable of inhibiting SARS-Cov-2 infection may help to address this immediate unmet clinical need and may be attractive to other countries that are also seeking new options for effective COVID-19 treatment. Our...

• Dissecting the novel mechanism of Reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification - CONCLUSION: RDNI can regulate ACE2, Mpro and PLP in COVID-19. The underlying mechanisms of RDNI in the treatment for COVID-19 may be related to the modulation of the cytokine levels and inflammation and its antipyretic activity by regulating the expression of MAPKs, PKC and p65 nuclear factor NF-κB.

• Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibition - In the current study, a structure-based virtual screening paradigm was used to screen a small molecular database against the Non-structural protein 15 (Nsp15) endoribonuclease of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 is the causative agent of the recent outbreak of coronavirus disease 2019 (COVID-19) which left the entire world locked down inside the home. A multi-step molecular docking study was performed against antiviral specific compounds (∼8722)...

• Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior - The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via anti-inflammatory actions exerted by the glucocorticoid receptor (GR). However, technical limitations have restricted our understanding of how GR is involved in the dynamics of NFκB in vivo. In this study, we used an improved lentiviral-based reporter to elucidate the time course of NFκB and...

• Feasibility of using alternative swabs and storage solutions for paired SARS-CoV-2 detection and microbiome analysis in the hospital environment - CONCLUSIONS: Compared to using a clinical-grade synthetic swab, detection of SARS-CoV-2 from environmental samples collected from ICU rooms of patients with COVID was similar using consumer-grade swabs, stored in 95% ethanol. The yield was best from the swab head rather than the eluent and the low level of RNase activity and lack of antibiotics in these samples makes it possible to perform concomitant microbiome analyses. Video abstract.

• Antibody persistence in the first six months following SARS-CoV-2 infection among hospital workers: a prospective longitudinal study - CONCLUSION: Neutralizing antibodies persisted at six months in almost all participants, indicating more durability than initially feared. Anti-RBD antibodies persisted better and even increased over time, possibly related to the preferential detection of progressively higher-affinity antibodies.

• Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and targeted treatment of autoimmune and inflammatory diseases - The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in health, but is released upon necrotic cell death as a bioactive mediator. IL-1α is also expressed by infiltrating myeloid cells within injured tissues. The cytokine binds the IL-1 receptor 1 (IL-1R1), as does IL-1β, and induces the same pro-inflammatory effects. Being a bioactive precursor released upon tissue damage and...

• Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice - SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein aggregates in lung fluid, increased lung alveolar wall thickness, and upregulation of serum cytokine levels. A serum protein called serum amyloid P (SAP) has a calming effect on the innate immune system and shows efficacy as a therapeutic for fibrosis...

• Host cell glutamine metabolism as a potential antiviral target - A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in...

From Patent Search

• COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS - - link

• A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link

• Covid 19 - Chewing Gum - - link

• STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link

• Fahrzeuglüftungssystem und Verfahren zum Betreiben eines solchen Fahrzeuglüftungssystems -

  Die Erfindung betrifft ein Fahrzeuglüftungssystem (1) zum Belüften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.

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• The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link

• The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link

• "AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link

• Mund-Nasen-Bedeckung -

  Mund-Nasen-Bedeckung (1), wobei die Mund-Nasen-Bedeckung (1) mindestens an einem Ohr eines Trägers magnetisch befestigbar ist.

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• Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link