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<title>21 July, 2022</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Do People Use Games to Compensate for Psychological Needs During Crises? A Mixed-Methods Study of Gaming During COVID-19 Lockdowns</strong> -
<div>
Do people use games to cope with adverse life events and crises? Research informed by self-determination theory proposes that people might compensate for thwarted basic psychological needs in daily life by seeking out games that satisfy those lacking needs. To test this, we conducted a preregistered mixed-method survey study (n = 285) on people’s gaming behaviours and need states during early stages of the COVID-19 pandemic (May 2020). We found qualitative evidence that gaming was an often actively sought out and successful means of replenishing particular needs, but one that could ‘backfire’ for some through an appraisal process discounting gaming as ‘unreal’. Meanwhile, contrary to our predictions, the quantitative data showed a “rich get richer, poor get poorer” pat- tern: need satisfaction in daily life positively correlated with need satisfaction in games. We derive methodological considerations and propose three potential explanations for this contradictory data pattern to pursue in future research.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/b2htf/" target="_blank">Do People Use Games to Compensate for Psychological Needs During Crises? A Mixed-Methods Study of Gaming During COVID-19 Lockdowns</a>
</div></li>
<li><strong>Validity Testing of the Conspiratorial Thinking and Anti-Expert Sentiment Scales during the COVID-19 Pandemic Across 24 Languages from a Large-Scale Global Dataset</strong> -
<div>
In this study, we tested the validity across two scales addressing conspiratorial thinking that may influence behaviors related to public health and the COVID-19 pandemic. Using the COVIDiSTRESSII Global Survey data from 12,261 participants, we validated the 4-item Conspiratorial Thinking Scale and 3-item Anti-Expert Sentiment Scale across 24 languages and dialects that were used by at least 100 participants per language. We employed confirmatory factor analysis, measurement invariance test, and measurement alignment for internal consistency testing. To test convergent validity of the two scales, we assessed correlations with trust in seven agents related to government, science, and public health. Although scalar invariance was not achieved when measurement invariance test was conducted initially, we found that both scales can be employed in further international studies with measurement alignment. Moreover, both conspiratorial thinking and anti-expert sentiments were significantly and negatively correlated with trust in all agents. Findings from this study provide supporting evidence for the validity of both scales across 24 languages for future large-scale international research.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/q3rkj/" target="_blank">Validity Testing of the Conspiratorial Thinking and Anti-Expert Sentiment Scales during the COVID-19 Pandemic Across 24 Languages from a Large-Scale Global Dataset</a>
</div></li>
<li><strong>Virtual Social Interaction and Loneliness Among Emerging Adults Amid the COVID-19 Pandemic</strong> -
<div>
Many social activities moved online during the global COVID-19 pandemic, yet research investigating whether virtual social interactions facilitate social connectedness has been inconclusive. In this study, participants completed online questionnaires assessing objective social isolation, loneliness, mental health, and virtual social interactions. There was clear evidence for worsening mental health among emerging adults during the COVID-19 pandemic characterized by large increases in depressive symptoms (mean increase = 8.35, 95% CI [6.97, 9.73], t(118) = 118, p &lt; .001), and large decrements in happiness (mean decrease = -0.71, 95% CI [-0.84, -0.57], t(118) = 10.09, p &lt; .001) and social satisfaction (mean decrease = -0.81, 95% CI [-1.00,-0.62], t(115) = 8.28, p &lt; .001) post-pandemic onset. In line with expectations, those living in larger households amid the pandemic reported lower levels of loneliness and higher levels of happiness. A negative association was found between household size (an index of objective social isolation) and loneliness, b = -3.01, t(79) = 2.60, p = .011, 95% CI [-5.32, -0.71], and a positive association was found between household size and happiness, b = 22.86, t(75) = 3.30, p = .001, 95% CI [9.06, 36.65]. However, contrary to expectations, there was no association between loneliness and frequency of virtual social interactions. There was also no association between frequency of virtual social interactions and either happiness or depression. More research investigating social connectedness in the context of virtual social interactions is warranted.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/2ghtd/" target="_blank">Virtual Social Interaction and Loneliness Among Emerging Adults Amid the COVID-19 Pandemic</a>
</div></li>
<li><strong>Generalizable Long COVID Subtypes: Findings from the NIH N3C and RECOVER Programs</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Accurate stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, the natural history of long COVID is incompletely understood and characterized by an extremely wide range of manifestations that are difficult to analyze computationally. In addition, the generalizability of machine learning classification of COVID-19 clinical outcomes has rarely been tested. We present a method for computationally modeling PASC phenotype data based on electronic healthcare records (EHRs) and for assessing pairwise phenotypic similarity between patients using semantic similarity. Our approach defines a nonlinear similarity function that maps from a feature space of phenotypic abnormalities to a matrix of pairwise patient similarity that can be clustered using unsupervised machine learning procedures. Using k-means clustering of this similarity matrix, we found six distinct clusters of PASC patients, each with distinct profiles of phenotypic abnormalities. There was a significant association of cluster membership with a range of pre-existing conditions and with measures of severity during acute COVID-19. Two of the clusters were associated with severe manifestations and displayed increased mortality. We assigned new patients from other healthcare centers to one of the six clusters on the basis of maximum semantic similarity to the original patients. We show that the identified clusters were generalizable across different hospital systems and that the increased mortality rate was consistently observed in two of the clusters. Semantic phenotypic clustering can provide a foundation for assigning patients to stratified subgroups for natural history or therapy studies on PASC.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.24.22275398v2" target="_blank">Generalizable Long COVID Subtypes: Findings from the NIH N3C and RECOVER Programs</a>
</div></li>
<li><strong>Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75-10.05, p=5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.28.22273040v3" target="_blank">Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative</a>
</div></li>
<li><strong>Antigenic evolution of SARS-CoV-2 in immunocompromised hosts</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Prolonged infections of immunocompromised individuals have been proposed as a crucial source of new variants of SARS-CoV-2 during the COVID-19 pandemic. In principle, sustained within-host antigenic evolution in immunocompromised hosts could allow novel immune escape variants to emerge more rapidly, but little is known about how and when immunocompromised hosts play a critical role in pathogen evolution. Here, we use a simple mathematical model to understand the effects of immunocompromised hosts on the emergence of immune escape variants in the presence and absence of epistasis. We show that when the pathogen does not have to cross a fitness valley for immune escape to occur (no epistasis), immunocompromised individuals have no qualitative effect on antigenic evolution (although they may accelerate immune escape if within-host evolutionary dynamics are faster in immunocompromised individuals). But if a fitness valley exists between immune escape variants at the between-host level (epistasis), then persistent infections of immunocompromised individuals allow mutations to accumulate, therefore facilitating rather than simply speeding up antigenic evolution. Our results suggest that better genomic surveillance of infected immunocompromised individuals and better global health equality, including improving access to vaccines and treatments for individuals who are immunocompromised (especially in lower- and middle-income countries), may be crucial to preventing the emergence of future immune escape variants of SARS-CoV-2.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.01.13.22269154v3" target="_blank">Antigenic evolution of SARS-CoV-2 in immunocompromised hosts</a>
</div></li>
<li><strong>Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed -1 ribosomal frameshifting</strong> -
<div>
SARS-CoV-2 is currently causing an unprecedented pandemic. While vaccines are massively deployed, we still lack effective large-scale antiviral therapies. In the quest for antivirals targeting conserved structures, we focused on molecules able to bind viral RNA secondary structures. Aminoglycosides are a class of antibiotics known to interact with the ribosomal RNA of both prokaryotes and eukaryotes and have previously been shown to exert antiviral activities by interacting with viral RNA. Here we show that the aminoglycoside geneticin is endowed with antiviral activity against all tested variants of SARS-CoV-2, in different cell lines and in a respiratory tissue model at non-toxic concentrations. The mechanism of action is an early inhibition of RNA replication and protein expression mediated by direct interaction with the -1 programmed ribosomal frameshift (PRF) signal. Using in silico modeling, we have identified a potential binding site of geneticin in the pseudoknot of frameshift RNA motif. Moreover, we have selected, through virtual screening, additional RNA binding compounds, interacting with the same site with increased potency.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.03.08.483429v2" target="_blank">Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed -1 ribosomal frameshifting</a>
</div></li>
<li><strong>ROLE OF DEEP LEARNING STRATEGIES IN DETECTING COVID-19 PNEUMONIA</strong> -
<div>
In this chapter, we will describe the various deep learning strategies used in detecting COVID-19 pneumonia with the help of different models.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/jwgsd/" target="_blank">ROLE OF DEEP LEARNING STRATEGIES IN DETECTING COVID-19 PNEUMONIA</a>
</div></li>
<li><strong>Vaccination shapes evolutionary trajectories of SARS-CoV-2</strong> -
<div>
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of genetic clades. New variants show intrinsic changes, notably increased transmissibility, as well as antigenic changes that reduce the cross-immunity induced by previous infections or vaccinations. How this functional variation shapes the global evolutionary dynamics has remained unclear. Here we show that selection induced by vaccination impacts on the recent antigenic evolution of SARS-CoV-2; other relevant forces include intrinsic selection and antigenic selection induced by previous infections. We obtain these results from a fitness model with intrinsic and antigenic fitness components. To infer model parameters, we combine time-resolved sequence data, epidemiological records, and cross-neutralisation assays. This model accurately captures the large-scale evolutionary dynamics of SARS-CoV-2 in multiple geographical regions. In particular, it quantifies how recent vaccinations and infections affect the speed of frequency shifts between viral variants.Our results show that timely neutralisation data can be harvested to identify hotspots of antigenic selection and to predict the impact of vaccination on viral evolution.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.19.500637v1" target="_blank">Vaccination shapes evolutionary trajectories of SARS-CoV-2</a>
</div></li>
<li><strong>Who believes in conspiracy theories? A meta-analysis on personality correlates</strong> -
<div>
Conspiracy theories are ubiquitous (e.g., 9/11, COVID-19) and can have negative consequences (e.g., prejudice). Thus, there is an increasing need for evidence-based recommendations (e.g. possible target groups) with respect to interventions and prevention measures. Present Bayesian three-level meta-analysis (686 correlations, 127 independent samples) includes a synthesis of the extant literature with respect to 12 personality correlates and their relationship with conspiracy beliefs. On average, people who believe in pseudoscience, suffer from paranoia or schizotypy, are narcissistic or religious/spiritual and have relatively low cognitive ability, are more likely to believe in conspiracy theories. Heterogeneity was partially explained by the examined moderators and no strong evidence for publication bias was found. Implications for developing tailored interventions are discussed in the article.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/pfw3x/" target="_blank">Who believes in conspiracy theories? A meta-analysis on personality correlates</a>
</div></li>
<li><strong>Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19</strong> -
<div>
As the world braces to enter its third year in the coronavirus disease 2019 (COVID-19) pandemic, the need for accessible and effective antiviral therapeutics continues to be felt globally. The recent surge of Omicron variant cases has demonstrated that vaccination and prevention alone cannot quell the spread of highly transmissible variants. A safe and nontoxic therapeutic with an adaptable design to respond to the emergence of new variants is critical for transitioning to treatment of COVID-19 as an endemic disease. Here, we present a novel compound, called SBCoV202, that specifically and tightly binds the translation initiation site of RNA-dependent RNA polymerase within the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome, inhibiting viral replication. SBCoV202 is a Nanoligomer,TM a molecule that includes peptide nucleic acid sequences capable of binding viral RNA with single-base-pair specificity to accurately target the viral genome. The compound has been shown to be safe and nontoxic in mice, with favorable biodistribution, and has shown efficacy against SARS-CoV-2 in vitro. Safety and biodistribution were assessed after three separate administration methods, namely intranasal, intravenous, and intraperitoneal. Safety studies showed the Nanoligomer caused no outward distress, immunogenicity, or organ tissue damage, measured through observation of behavior and body weight, serum levels of cytokines, and histopathology of fixed tissue, respectively. SBCoV202 was evenly biodistributed throughout the body, with most tissues measuring Nanoligomer concentrations well above the compound KD of 3.37 nM. In addition to favorable availability to organs such as the lungs, lymph nodes, liver, and spleen, the compound circulated through the blood and was rapidly cleared through the renal and urinary systems. The favorable biodistribution and lack of immunogenicity and toxicity set Nanoligomers apart from other antisense therapies, while the adaptability of the nucleic acid sequence of Nanoligomers provides a defense against future emergence of drug resistance, making these molecules an attractive potential treatment for COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.19.500688v1" target="_blank">Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19</a>
</div></li>
<li><strong>Regulation of mRNA transcripts, protein isoforms, glycosylation and spatial localization of ACE2 and other SARS-CoV-2-associated molecules in human airway epithelium upon viral infection and type 2 inflammation</strong> -
<div>
SARS-CoV-2 infection continues to pose a significant life threat, especially in patients with comorbidities. It remains unknown, if asthma or allergen- and virus-induced airway inflammation are risk factors or can constitute some forms of protection against COVID-19. ACE2 and other SARS-CoV-2-related host proteins are limiting factors of an infection, expression of which is regulated in a more complex way than previously anticipated. Hence, we studied the expression of ACE2 mRNA and protein isoforms, together with its glycosylation and spatial localization in house dust mite (HDM)-, interleukin-13 (IL-13)- and human rhinovirus (RV)-induced inflammation in the primary human bronchial airway epithelium of healthy subjects and patients with asthma. IL-13 decreased the expression of long ACE2 mRNA and glycosylation of full-length ACE2 protein via alteration of the N-linked glycosylation process, limiting its availability on the apical side of ciliated cells. RV infection increased short ACE2 mRNA, but it did not influence its protein expression. HDM exposure did not affect ACE2 mRNA or protein. IL-13 and RV significantly regulated mRNA, but not protein expression of TMPRSS2 and NRP1. Regulation of ACE2 and other host proteins was similar in healthy and asthmatic epithelium, underlining the lack of intrinsic differences, but rather the dependence on the inflammatory milieu in the airways.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.19.500631v1" target="_blank">Regulation of mRNA transcripts, protein isoforms, glycosylation and spatial localization of ACE2 and other SARS-CoV-2-associated molecules in human airway epithelium upon viral infection and type 2 inflammation</a>
</div></li>
<li><strong>Evasion of neutralizing antibodies by Omicron sublineage BA.2.75</strong> -
<div>
Towards the end of 2021, SARS-CoV-2 vaccine effectiveness was threatened by the emergence of the Omicron clade (B.1.1.529), with more than 30 mutations in spike. Recently, several sublineages of Omicron, including BA.2.12.1, BA.4, and BA.5, have demonstrated even greater immune evasion, and are driving waves of infections across the globe. One emerging sublineage, BA.2.75, is increasing in frequency in India and has been detected in at least 15 countries as of 19 July 2022. Relative to BA.2, BA.2.75 carries nine additional mutations in spike. Here we report the sensitivity of the BA.2.75 spike to neutralization by a panel of clinically-relevant and pre-clinical monoclonal antibodies, as well as by serum from blood donated in Stockholm, Sweden, before and after the BA.1/BA.2 infection wave. BA.2.75 does not show greater immune evasion than the currently-dominating BA.5 in our set of serum samples, and exhibits moderate susceptibility to tixagevimab and cilgavimab that form a widely used monoclonal antibody cocktail (Evusheld).
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.19.500716v1" target="_blank">Evasion of neutralizing antibodies by Omicron sublineage BA.2.75</a>
</div></li>
<li><strong>A Pan-respiratory Antiviral Chemotype Targeting a Transient Host Multiprotein Complex</strong> -
<div>
We present a small molecule chemotype, identified by an orthogonal drug screen, exhibiting nanomolar activity against members of all the six viral families causing most human respiratory viral disease, with a demonstrated barrier to resistance development. Antiviral activity is shown in mammalian cells, including human primary bronchial epithelial cells cultured to an air-liquid interface and infected with SARS-CoV-2. In animals, efficacy of early compounds in the lead series is shown by survival (for a coronavirus) and viral load (for a paramyxovirus). The drug target is shown to include a subset of the protein 14-3-3 within a transient host multi-protein complex containing components implicated in viral lifecycles and in innate immunity. This multi-protein complex is modified upon viral infection and largely restored by drug treatment. Our findings suggest a new clinical therapeutic strategy for early treatment upon upper respiratory viral infection to prevent progression to lower respiratory tract or systemic disease.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.17.426875v3" target="_blank">A Pan-respiratory Antiviral Chemotype Targeting a Transient Host Multiprotein Complex</a>
</div></li>
<li><strong>The First Geographic Identification by Country of Sustainable Mutations of SARS-COV-2 Sequence Samples: Worldwide Natural Selection Trends</strong> -
<div>
The high mutation rates of RNA viruses, coupled with short generation times and large population sizes, allow viruses to evolve rapidly and adapt to the host environment. The rapidity of viral mutation also causes problems in developing successful vaccines and antiviral drugs. With the spread of SARS-CoV-2 worldwide, thousands of mutations have been identified, some of which have relatively high incidences, but their potential impacts on virus characteristics remain unknown. The present study analyzed mutation patterns, SARS-CoV-2 AASs retrieved from the GISAID database containing 10,500,000 samples. Python 3.8.0 programming language was utilized to pre-process FASTA data, align to the reference sequence, and analyze the sequences. Upon completion, all mutations discovered were categorized based on geographical regions and dates. The most stable mutations were found in nsp1(8% S135R), nsp12(99.3% P323L), nsp16 (1.2% R216C), envelope (30.6% T9I), spike (97.6% D614G), and Orf8 (3.5% S24L), and were identified in the United States on April 3, 2020, and England, Gibraltar, and, New Zealand, on January 1, 2020, respectively. The study of mutations is the key to improving understanding of the function of the SARS-CoV-2, and recent information on mutations helps provide strategic planning for the prevention and treatment of this disease. Viral mutation studies could improve the development of vaccines, antiviral drugs, and diagnostic assays designed with high accuracy, specifically useful during pandemics. This knowledge helps to be one step ahead of new emergence variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.18.500565v1" target="_blank">The First Geographic Identification by Country of Sustainable Mutations of SARS-COV-2 Sequence Samples: Worldwide Natural Selection Trends</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Puerto Rico COVID-19 Vaccine Uptake Study</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Educational intervention<br/><b>Sponsors</b>:   University of Puerto Rico;   National Institutes of Health (NIH);   National Institute on Minority Health and Health Disparities (NIMHD)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bank of Human Leukocytes From COVID-19 Convalescent Donors With an Anti-SARS-CoV-2 Cellular Immunity</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Generation of a biobank allowing the cryopreservation of leucocytes from COVID19 convalescent donors<br/><b>Sponsor</b>:   Central Hospital, Nancy, France<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Generation of SARS-CoV-2-specific T Lymphocytes From Recovered Donors and Administration to High-risk COVID-19 Patients</strong> - <b>Condition</b>:   Severe COVID-19<br/><b>Interventions</b>:   Biological: Coronavirus-2-specific T cells;   Other: standard of care (SOC)<br/><b>Sponsors</b>:   George Papanicolaou Hospital;   General Hospital Of Thessaloniki Ippokratio<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beta-glucans for Hospitalised Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: MC 3x3;   Drug: Placebo<br/><b>Sponsors</b>:   Concentra Educacion e Investigación Biomédica;   Wohlstand Pharmaceutical<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Molnupiravir 200 mg<br/><b>Sponsors</b>:   University of Witwatersrand, South Africa;   Bill and Melinda Gates Foundation<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Engaging Staff to Improve COVID-19 Vaccination Response at Long-Term Care Facilities</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Full Intervention;   Other: Enhanced Usual Care<br/><b>Sponsors</b>:   Kaiser Permanente;   Patient-Centered Outcomes Research Institute;   Global Alliance to Prevent Prematurity and Stillbirth (GAPPS)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Value of Montelukast as a Potential Treatment of Post COVID-19 Persistent Cough</strong> - <b>Condition</b>:   Post COVID-19<br/><b>Intervention</b>:   Drug: Montelukast Sodium Tablets<br/><b>Sponsor</b>:   Assiut University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Topical Antibacterial Agents for Prevention of COVID-19</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV2 Infection<br/><b>Interventions</b>:   Drug: Neosporin;   Other: Vaseline<br/><b>Sponsors</b>:   Yale University;   Bill and Melinda Gates Foundation<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">**NanoMn®_COVID-19 A Prospective, Multicenter, Randomized, Placebo-controlled, Parallel-group, Double-blind Trial to Evaluate the Clinical Efficacy of NanoManganese® on Top of Standard of Care, in Adult Patients With Moderate to Severe Coronavirus Disease 2019 (COVID-19)** - <b>Condition</b>:   COVID-19 Pandemic<br/><b>Interventions</b>:   Drug: Placebo;   Drug: Experimental drug<br/><b>Sponsor</b>:   Medesis Pharma SA<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Recombinant COVID-19 Vaccine (Sf9 Cell) as a Booster</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 Vaccine (Sf9 Cell);   Biological: COVID-19 Vaccine (Vero Cell), Inactivated<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) as a Booster</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 variant Vaccine (Sf9 Cell);   Biological: COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: mRNA COVID-19 vaccine (Moderna);   Biological: Viral Vector COVID-19 vaccine (AstraZeneca)<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of Effectiveness of Proprietary Rehabilitation Program in Patients After COVID-19 Infection</strong> - <b>Conditions</b>:   COVID-19;   Rehabilitation<br/><b>Interventions</b>:   Other: Respiratory training with the use of resistance set on respiratory muscle trainer;   Other: Respiratory training without resistance set on respiratory muscle trainer<br/><b>Sponsor</b>:   Medical University of Bialystok<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention</strong> - <b>Condition</b>:   Post-acute COVID-19 Syndrome<br/><b>Intervention</b>:   Behavioral: PACS Coping and Recovery (PACS-CR) Intervention<br/><b>Sponsor</b>:   VA Office of Research and Development<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mineralocorticoid Use in COVID-19 Patients</strong> - <b>Conditions</b>:   COVID-19;   ARDS<br/><b>Intervention</b>:   Drug: Fludrocortisone Acetate 0.1 MG<br/><b>Sponsor</b>:   Ain Shams University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Xanthohumol as an Adjuvant Therapy in Critically Ill COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19 Respiratory Infection<br/><b>Intervention</b>:   Biological: Xanthohumol - prenylated chalcone extracted from female inflorescences of hop cones (Humulus lupus). Hop-RXn™, BioActive-Tech Ltd, Lublin, Poland; http://xanthohumol.com.pl/<br/><b>Sponsor</b>:   Medical University of Lublin<br/><b>Suspended</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents</strong> - Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these proteases. However, the intrinsic, high electrophilicity of the aldehyde group is associated with safety concerns and metabolic instability, limiting the use of aldehyde inhibitors as drugs. We have developed a novel class of compounds, self-masked…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 Treatment</strong> - Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also been identified as a potent inhibitor of SARS-CoV-2 infection in vitro , generating interest in its use for the treatment or prevention of COVID-19. Unfortunately, there are several potential issues with using niclosamide for COVID-19, including low bioavailability, significant polypharmacology, high cellular toxicity, and unknown…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2</strong> - Coronavirus disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The infection causes dysregulation of the immune system with a cytokine storm that eventually leads to fatal acute respiratory distress syndrome (ARDS) and further irreversible pulmonary fibrosis. Therefore, the promising way to inhibit infection is to disrupt the binding and fusion between the viral spike and the host ACE2 receptor….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploration of molecular targets and mechanisms of Chinese medicinal formula Acacia Catechu -Scutellariae Radix in the treatment of COVID-19 by a systems pharmacology strategy</strong> - Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In China, the Acacia catechu (AC)-Scutellariae Radix (SR) formula has been widely used for pulmonary infection in clinical practice for several centuries. However, the potential role and mechanisms of this formula against COVID-19 remains unclear. The present study was designed to dissect the active ingredients, molecular targets, and the therapeutic mechanisms of AC-SR formula in the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The global succinylation of SARS-CoV-2-infected host cells reveals drug targets</strong> - SARS-CoV-2, the causative agent of the COVID-19 pandemic, undergoes continuous evolution, highlighting an urgent need for development of novel antiviral therapies. Here we show a quantitative mass spectrometry-based succinylproteomics analysis of SARS-CoV-2 infection in Caco-2 cells, revealing dramatic reshape of succinylation on host and viral proteins. SARS-CoV-2 infection promotes succinylation of several key enzymes in the TCA, leading to inhibition of cellular metabolic pathways. We…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB Activation</strong> - Patients with severe coronavirus disease 2019 tend to have high levels of proinflammatory cytokines, which eventually lead to cytokine storm and the development of acute respiratory distress syndrome. However, the detailed molecular mechanisms of proinflammatory cytokine production remain unknown. Here, we screened severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genes and found that nonstructural protein 6 (NSP6) and open reading frame 7a (ORF7a) activated the NF-κB pathway. NSP6…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recent Progress in the Development of Opaganib for the Treatment of Covid-19</strong> - The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive humanitarian and economic stress across the world. Although antivirals active against mild disease have been identified recently, new drugs to treat moderate and severe Covid-19 patients are needed. Sphingolipids regulate key pathologic processes, including viral proliferation and pathologic host inflammation. Opaganib (aka ABC294640) is a first-in-class clinical drug targeting sphingolipid metabolism for the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A computational evaluation of FDA medicines’ ability to inhibit hypoxia-inducible factor prolyl hydroxylase-2 (PHD-2) for acute respiratory distress syndrome</strong> - COVID-19 infection is associated with a significant fatality rate in individuals suffering from severe acute respiratory distress syndrome (ARDS). Among the several possibilities, inhibition of hypoxia-inducible factor prolyl hydroxylase-2 or prolyl hydroxylase domain-containing protein 2 (PHD2) in a hypoxia-independent way is a prospective therapeutic target for the treatment of ARDS. Vadadustat, Roxadustat, Daprodustat, Desidustat, and Enarudustat are the available clinical trial inhibitors….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting the Conserved Sequence of the Substrate for the Proteinase of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2) Using Nano-Networks: Efficacy, Stability, and No Cytotoxicity</strong> - Herein, we designed a nano peptide that contains three important motifs for targeting the chemotrypsin-like cysteine protease (3CL^(pro)) which is the enzyme responsible for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication. The novel nano peptide contains the Nap Phe-Phe motif that is responsible for peptide self-assembly, an octapeptide (Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe) motif where the enzyme recognizes the substrate and induces enzyme sensitivity, and a tetrapeptide…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibiting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants: Targeting the Spike and Envelope Proteins Using Nanomaterial Like Peptides</strong> - Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused significant death, economic crisis, and the world to almost completely shut down. This present study focused on targeting the novel SARS-CoV-2 envelope protein, which has not been frequently mutating, and the S protein with a much larger peptide capable of inhibiting virus-mammalian cell attraction. In doing so, molecular dynamics software was used here to model six peptides…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Complement C3 activation in the ICU: Disease and therapy as Bonnie and Clyde</strong> - Patients in the intensive care unit (ICU) often straddle the divide between life and death. Understanding the complex underlying pathomechanisms relevant to such situations may help intensivists select broadly acting treatment options that can improve the outcome for these patients. As one of the most important defense mechanisms of the innate immune system, the complement system plays a crucial role in a diverse spectrum of diseases that can necessitate ICU admission. Among others, myocardial…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Application of emetine in SARS-CoV-2 treatment: regulation of p38 MAPK signaling pathway for preventing emetine-induced cardiac complications</strong> - Emetine is one of the most highly potent anti-SARS-CoV-2 agents ever identified. In addition to having strong anti-SARS-CoV-2 activities, emetine has other valuable therapeutic effects such as strong anti-inflammatory and anti-arterial pulmonary hypertension (APH) properties, which are suitable for the treatment of COVID-19. Its proper concomitant therapeutic effect has led researchers to test this compound in clinical trials to combat COVID-19. However, due to the risks of cardiac…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint</strong> - The spike protein on sarbecovirus virions contains two external, protruding domains: an N-terminal domain (NTD) with unclear function and a C-terminal domain (CTD) that binds the host receptor, allowing for viral entry and infection. While the CTD is well studied for therapeutic interventions, the role of the NTD is far less well understood for many coronaviruses. Here, we demonstrate that the spike NTD from SARS-CoV-2 and other sarbecoviruses binds to unidentified glycans in vitro similarly to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molnupiravir for the treatment of COVID-19</strong> - Molnupiravir (MK-4482, EIDD-2801) is a promising broad-spectrum experimental antiviral developed by Merck &amp; Co. It is a nucleoside analogue prodrug that undergoes rapid conversion into nucleoside triphosphate (NTP) by intracellular metabolic processes. NTP inhibits viral polymerase by acting as an alternative substrate. Molnupiravir was initially developed to treat influenza and Venezuelan equine encephalitis virus (VEEV) infection as it exerts its antiviral activity by inhibiting RNA-dependent…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 vaccine hesitancy in Africa: a scoping review</strong> - CONCLUSIONS: Our review demonstrated the contextualized and multifaceted reasons inhibiting or encouraging vaccine uptake in African countries. This evidence is key to operationalizing interventions based on facts as opposed to assumptions. Our paper provided important considerations for addressing the challenge of COVID-19 vaccine hesitancy and blunting the impact of the pandemic in Africa.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>​​Britain Unravels in a Heat Wave</strong> - The U.K., like its population, is not built for heat. As temperatures surpassed a hundred and four degrees, schools closed, roads melted, and confusion reigned. - <a href="https://www.newyorker.com/news/letter-from-the-uk/britain-unravels-in-a-heat-wave">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>​​Another Likely Effect of the Roe Reversal: Higher Health-Care Costs</strong> - Abortion bans could lead to more high-risk pregnancies, which could raise the price of providing health care to women. - <a href="https://www.newyorker.com/business/currency/another-likely-effect-of-the-roe-reversal-higher-health-care-costs">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The True Costs of Inflation in Small-Town Texas</strong> - When R-BBQ had to cut its hours and reduce its portions, the effects rippled through the community. - <a href="https://www.newyorker.com/news/letter-from-the-southwest/the-true-costs-of-inflation-in-small-town-texas">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump Seeks Money and Revenge in Hosting the New Saudi Golf League</strong> - The former President ignores protests from 9/11 families and tries to undermine the P.G.A. Tour that shunned him. - <a href="https://www.newyorker.com/news/our-columnists/trump-seeks-money-and-revenge-in-hosting-new-saudi-golf-league">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ivana Trump Was Always the Boss of Her</strong> - She seemed animated by the attention she received, even when it was negative. - <a href="https://www.newyorker.com/news/afterword/ivana-trump-was-always-the-boss-of-her">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>What the end of Roe might mean for the future of digital privacy rights</strong> -
<figure>
<img alt="U.S. representatives protest outside the US Capitol carry a banner that reads “Our bodies. Our courts. Our democracy.”" src="https://cdn.vox-cdn.com/thumbor/miVK08XPafkkPYcLi_fk6yWtd6c=/0x0:5333x4000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71158218/GettyImages_1409758838.0.jpg"/>
<figcaption>
House Democrats participate in an abortion rights protest in front of the Capitol building. | Anna Moneymaker/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Roe reversal showed the need for data privacy laws. Will that be enough to get them?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G5SUuc">
Rep. Sara Jacobs (D-CA) uses a period-tracking app. So do many of her friends and constituents, who messaged her about those apps after the <a href="https://www.vox.com/23055298/supreme-court-roe-abortion-rights">Supreme Court’s decision to overturn <em>Roe v. Wade</em></a> leaked. Major privacy concerns with period tracking apps <a href="https://www.vox.com/recode/2022/7/6/23196809/period-apps-roe-dobbs-data-privacy-abortion">emerged</a> earlier this year, as the possibility that abortion could become illegal in certain parts of the country loomed. That’s when Jacobs realized many people didn’t know what they were supposed to do to keep their online data private.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NQSG90">
“I realized each individual person shouldn’t have to figure this out on their own,” Jacobs told Recode. “It’s our job as a government to protect this very sensitive and personal data.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pJ0P74">
In response, she introduced the <a href="https://www.congress.gov/bill/117th-congress/house-bill/8111?r=2&amp;s=1">My Body, My Data Act</a> in June. The bill requires that reproductive and sexual health data collection be minimized, that users are able to access and delete the data about them that has been collected, and that consumers have the right to sue companies they believe have violated those rules and their privacy. Period apps would be covered by the law, but so would a lot of other things — which is good, because the health privacy problem extends well beyond period apps.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7OLk9u">
“It becomes really scary to think about all of the ways this data can be used and the fact that we have no protections against it right now,” Jacobs said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IXKTOR">
Her bill is just one example of how the reversal of <em>Roe</em> and subsequent criminalization of abortion in several states may have put the biggest spotlight on online privacy since <a href="https://www.vox.com/2018/4/10/17207394/cambridge-analytica-facebook-zuckerberg-trump-privacy-scandal">Facebook’s Cambridge Analytica scandal</a>. It’s been less than a month since the Supreme Court’s decision came down, but the other two branches of government have already taken action. Congress <a href="https://techcrunch.com/2022/07/08/house-oversight-letter-abortion-period-apps-data-brokers/">is investigating</a> apps and data brokers whose information could be used against abortion seekers and providers, and a federal consumer privacy bill that has been years in the works is making unprecedented progress in Congress. Meanwhile, President Biden addressed digital privacy <a href="https://www.federalregister.gov/documents/2022/07/13/2022-15138/protecting-access-to-reproductive-healthcare-services">in an executive order</a> aimed at protecting reproductive health care. And some states, which have led the way on consumer privacy laws, are considering new or stronger privacy laws.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5XWlLc">
“I do think it is kind of a turning point,” Caitlin Seeley George, campaigns and managing director of digital advocacy group Fight for the Future, said. “Congress should see this as an opportunity where they have public attention, they have a directive from the executive, they should absolutely be doing all they can on this issue.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UWTBv9">
Some lawmakers, like Jacobs, weren’t previously known as data privacy advocates. Others who have been beating the privacy drum for years see the <em>Roe</em> reversal as a way to make the public more aware of the problem and supportive of laws that could solve it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WzbX8z">
“I’ve had a huge response from Oregonians and allies here in Congress since the draft opinion was first released,” said Sen. Ron Wyden (D-OR), a <a href="https://www.vox.com/recode/2020/8/5/21339766/zuckerberg-privacy-law-facebook-congress-wyden">longtime privacy hawk</a> who, with Sen. Mazie Hirono (D-HI), sponsored a Senate version of Jacobs’s bill. “The movement to secure personal information against political prosecutions will only grow as the fallout from Republicans’ crusade against women becomes clear.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JjzUhk">
Joining Jacobs’s bill in the post-<em>Roe</em> digital privacy fight is the <a href="https://www.warren.senate.gov/newsroom/press-releases/warren-wyden-murray-whitehouse-sanders-introduce-legislation-to-ban-data-brokers-from-selling-americans-location-and-health-data#:~:text=The%20Health%20and%20Location%20Data%20Protection%20Act%20will%20ban%20brokers,for%20this%20%24200%20billion%20industry.%E2%80%9D">Health and Location Data Protection Act</a>, which would ban data brokers from selling or sharing health data and location data. And House Speaker Nancy Pelosi <a href="https://www.speaker.gov/newsroom/62722-0">said in a recent letter</a> that House Democrats were considering legislation that protects data stored in reproductive health apps.
</p>
<div class="c-float-right">
<aside id="t9jxLZ">
<q>“It’s our job as a government to protect this very sensitive and personal data”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FglIiL">
Alongside the president’s executive order, the Biden administration has made digital privacy part of its post-<em>Roe</em> reproductive health agenda. The Department of Health and Human Services <a href="https://www.hhs.gov/about/news/2022/06/29/hhs-issues-guidance-to-protect-patient-privacy-in-wake-of-supreme-court-decision-on-roe.html">issued new guidance</a> that included <a href="https://www.hhs.gov/hipaa/for-professionals/privacy/guidance/cell-phone-hipaa/index.html">best practices</a> for finding and using private and secure online services. And the Federal Trade Commission <a href="https://www.ftc.gov/business-guidance/blog/2022/07/location-health-other-sensitive-information-ftc-committed-fully-enforcing-law-against-illegal-use">issued a statement</a> saying the agency will “will vigorously enforce the law if we uncover illegal conduct that exploits Americans’ location, health, or other sensitive data.” This week, the Federal Communications Commission also <a href="https://www.fcc.gov/document/rosenworcel-probes-mobile-carriers-data-privacy-practices">announced a probe</a> into mobile carriers’ privacy practices and how they handle consumers’ location data (the agency did not say if this was a response to the decision).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OH4AWU">
And while Republicans aren’t likely to sign onto any privacy legislation introduced as a direct response to a Supreme Court decision their party supports, some of them do support another data privacy bill that was introduced last month: the American Data Privacy and Protection Act (ADPPA), a bipartisan, bicameral bill that just became the first consumer privacy bill to make it out of a full committee markup, and with a nearly unanimous vote. If nothing else, that’s an indication of just how difficult it has been to get anywhere on such laws, even after years of trying. It may also be an indication of how motivated some lawmakers are to pass a law this time around.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0j66yx">
But some experts aren’t so sure that even this will be enough to put a federal consumer privacy law on the books. India McKinney, director of federal affairs at the Electronic Frontier Foundation, said online tracking and surveillance has been “so creepy and so weird for so long” that she’s not sure if the fallout from the Supreme Court’s <em>Dobbs</em> decision will be the thing that makes the dangers of having few privacy protections click for the American public.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jReNgi">
“I suppose that if something good does come out of Dobbs, it would be that it leads to increased privacy awareness [or] legislation,” Jen King, privacy and data policy fellow at the Stanford University Institute for Human-Centered Artificial Intelligence, said. “That said, because <em>Dobbs</em> only directly implicates half of our population, I’m slightly skeptical that will be the end result.”
</p>
<h3 id="qqo0Ep">
A bipartisan, bicameral federal privacy bill is making progress
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vac67V">
Tech companies have been able to build entire business models and ecosystems around tracking people online and off. It’s not just Big Tech, either. There’s also a world of data brokers and app developers that, in the absence of federal privacy legislation, track us in ways many people don’t understand or expect. Those companies are facing new scrutiny as reports detail how marketplaces sell aggregated data about <a href="https://www.vice.com/en/article/m7vzjb/location-data-abortion-clinics-safegraph-planned-parenthood">visits to abortion clinics</a> or <a href="https://www.vice.com/en/article/v7d9zd/data-marketplace-selling-clue-period-tracking-data">lists of devices</a> that have period apps installed. Some companies have tried to smooth things over by <a href="https://www.warren.senate.gov/newsroom/press-releases/warren-announces-two-key-data-brokers-commitment-to-permanently-stop-selling-location-data-of-people-seeking-abortion-services">changing</a> certain <a href="https://blog.google/technology/safety-security/protecting-peoples-privacy-on-health-topics/">data practices</a> around sensitive information like reproductive health. But without an actual law, we’re left to rely on the same companies that built their businesses around tracking us to keep their promises to stop doing so.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zudcn7">
“We can’t rely on the goodwill of Big Tech to protect sensitive information that may affect women’s access to abortion and reproductive health care services — or worse, lead to their prosecution,” said Sen. Elizabeth Warren (D-MA), who introduced the Health and Location Data Protection Act (of which Wyden is a cosponsor). “We need federal legislation with strong privacy guarantees, and my bill would do just that.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nUrPL0">
But any federal privacy bill needs some Republican support to pass. ADPPA has that support and has been heralded by many as the best chance yet that Congress has to pass a privacy law. Both sides have made concessions on things that prevented them from putting out a bipartisan privacy bill before. Some privacy and consumer advocacy groups, like <a href="https://twitter.com/JustinBrookman/status/1549417967934492674">Consumer Reports</a> and <a href="https://epic.org/release-epic-urges-support-for-updated-american-data-privacy-and-protection-act/">EPIC</a>, are cautiously optimistic about the bill. ADPPA doesn’t explicitly address the <em>Roe</em> reversal, but many of its provisions would protect health privacy just the same.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XFETML">
“This is an area where Congress should be able to come together to get something done,” said Rep. Ro Khanna (D-CA), who wrote an <a href="https://www.nytimes.com/2018/10/04/opinion/ro-khanna-internet-bill-of-rights.html?utm_source=newsletter&amp;utm_medium=email&amp;utm_campaign=sendto_newslettertest&amp;stream=top">Internet Bill of Rights</a> in 2018. “I’m hopeful that renewed momentum on this issue will catalyze Congress to act.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="grCoQg">
Rep. Suzan DelBene, a moderate Democrat from Washington state who has proposed <a href="https://www.vox.com/recode/22301174/federal-privacy-bill-suzan-delbene">several privacy bills</a> over the years, said a national consumer privacy law would better serve the American public than legislation like Jacobs’s, which targets specific types of data.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="a7xBjG">
“We should not be playing whack-a-mole with narrow privacy policies,” DelBene said. “We need a strong national foundational privacy standard so we are forward-looking and not just reactive.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4OBUL7">
But ADPPA faces significant obstacles, even with the momentum the <em>Roe</em> reversal may have provided. Many California Democrats <a href="https://about.bgov.com/news/california-democrats-push-for-stronger-privacy-protection-bill/">have said</a> they won’t support a bill that weakens their state’s privacy law. Sen. Maria Cantwell (D-WA) currently <a href="https://www.washingtonpost.com/politics/2022/06/30/sen-cantwells-elusive-endorsement-puzzles-privacy-talks/">opposes the bill</a>, and as chair of the Senate Commerce Committee, her support is necessary for the bill to go anywhere. Sens. Wyden, Brian Schatz (D-HI), and Richard Blumenthal (D-CT) have also <a href="https://www.washingtonpost.com/politics/2022/06/15/senate-holdouts-pose-hurdle-congresss-surging-privacy-push/">spoken out</a> against the bill. A Senate aide close to the discussions who was not authorized to speak publicly told Recode there’s a chance that the <em>Dobbs</em> decision could make some lawmakers less willing to compromise on what they see as a weaker bill now that the need for a stronger one is more apparent than ever.
</p>
<div class="c-float-left">
<aside id="DIbUH9">
<q>“We can’t rely on the goodwill of Big Tech to protect sensitive information”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="j7lHOE">
While most members of Congress avoided the subject, Rep. Anna Eshoo (D-CA) mentioned the Supreme Court decision during ADPPA’s markup, saying: “The legislation should take head-on the new world women are living in since June 24.” She added that the law should close a loophole that would allow law enforcement to access data to help prosecute people for getting abortions. Eshoo was one of just two members of Congress to vote against advancing ADPPA to a House floor vote. The other, Nanette Barragán, also represents California.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v4XCjd">
Time is also running out to pass ADPPA this session, and there’s no guarantee it will pass in the next one. If Republicans attain a majority in the Senate, it’s likely that Sen. Ted Cruz (R-TX) will be heading up the Commerce committee. His priorities might not be the same.
</p>
<h3 id="vsA0Yw">
States may continue to take the lead on privacy
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W1n3p4">
Some states have already done what the federal government hasn’t. Thanks to the <em>Roe</em> reversal, more might be on the way.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2feAZJ">
“The vast majority of privacy laws that have passed over the past 10-20 years come from the states,” Kade Crockford, director of the Technology for Liberty Program of the ACLU of Massachusetts, said. “I expect that that is going to continue to be the case in the short-term future.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Vv8tFS">
McKinney, of the Electronic Frontier Foundation, said Illinois’s <a href="https://www.vox.com/recode/2020/7/23/21335806/facebook-settlement-illinois-facial-recognition-photo-tagging">Biometric Information Privacy Act</a>, Vermont’s <a href="https://www.huntonprivacyblog.com/2018/06/13/vermont-enacts-nations-first-data-broker-legislation/">Data Broker Act</a>, and California’s <a href="https://www.vox.com/recode/2019/12/30/21030754/ccpa-2020-california-privacy-law-rights-explained">Consumer Privacy Act</a> and <a href="https://www.vox.com/2020/11/4/21534746/california-proposition-24-digital-privacy-results">Privacy Rights Act</a> were examples of states that passed privacy laws in lieu of federal action. New York is also <a href="https://www.nysenate.gov/legislation/bills/2021/A84">trying to ban</a> controversial geofence and keyword search warrants, where law enforcement orders companies to turn over a list of devices that were in a certain area or a list of devices or accounts that searched for certain terms, respectively.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M6FMrK">
Rep. Jacobs says that, even after all the outcry over period apps and privacy issues, she has yet to delete hers. Why? Because, she says, she lives in a state that has a strong, comprehensive privacy law.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6LgbMU">
“I am very grateful to live in California,” Jacobs said.
</p></li>
<li><strong>How to fall back in love with reading</strong> -
<figure>
<img alt="An illustration of a pile of books against a pink background." src="https://cdn.vox-cdn.com/thumbor/qEth5QO3RChAycgFgCqhjuO8seo=/375x0:2626x1688/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71158105/STORY_4_SET_2.0.png"/>
<figcaption>
Shanée Benjamin for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Even when your brain feels like mush.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3V5f3t">
I doubt you need to be told you should be reading more. There’s a good chance you struggle to make time for reading, and it feels like just another obligation, like hitting your daily step goal, or drinking more water.<em> </em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vUw3Sj">
You’re not alone. In early 2021, nearly a quarter of Americans <a href="https://www.pewresearch.org/fact-tank/2021/09/21/who-doesnt-read-books-in-america/">told the Pew Research Center</a> that they hadn’t read any books at all the previous year. Earlier this year, <a href="https://news.gallup.com/poll/388541/americans-reading-fewer-books-past.aspx">a Gallup poll revealed</a> that even those who were reading books were reading fewer than ever.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5hrENw">
“So many people tell me that they used to be a reader and then they just fell out of it,” Lynn Lobash, the New York Public Library’s associate director of reader services, told me, recounting conversations from the past few years. “It’s hard to get back into a practice once you’ve lost it.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I2E6Ne">
Because, look, it’s not easy! Books require sustained attention, something few of us have (and <a href="https://www.mayoclinichealthsystem.org/hometown-health/featured-topic/brain-fog-from-long-covid-19">some of us have lost altogether</a>) in these pandemic-riddled, anxiety-inducing times. Given some free time, you’ve probably got a million other things you could be doing: shows to binge, movies to half-watch, browser tabs to skim. Even if you loved to read as a child, when adulthood hits, reading can go out the window, relegated to beach reading on vacations and maybe a couple of books crammed into the corners of life.
</p>
<div class="c-float-right">
<aside id="8RzBxq">
<q>There is no such thing as the correct book to read</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pp7rCC">
Even if you do manage to pick up a book, you might feel lingering guilt if it isn’t an <em>important</em> book, or at least an improving one. “There is no such thing as the correct book to read,” Allison Escoto reminded me over Zoom, a bookcase looming behind her. Escoto is the head librarian and education director at the Center for Fiction in Brooklyn. The canon of “important books” — what they are, and who gets to choose them — has been in a vibrant state of reexamination and expansion in recent years, she reminded me, and that means the “notion of the correct book, or the right book, or the acceptable book is itself under scrutiny.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BNzHox">
In fact, numerous studies seem to suggest that when it comes to the psychological benefits of reading, just doing it might matter as much or more than the content. <a href="https://archive.nytimes.com/well.blogs.nytimes.com/2016/08/03/read-books-live-longer/?_r=0">Researchers have found</a> that people who spend a few hours per week reading books live longer than those who don’t read, or who read only articles in periodicals; the sustained act of cognition that books demand seems to be the deciding factor. Other research finds a<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733342/"> vast array of social-cognitive benefits</a> that come with reading, particularly reading fiction, aiding the brain’s development in understanding others and imagining the world.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="guwAnd">
Some <a href="https://hbr.org/2020/03/the-case-for-reading-fiction#:~:text=Recent%20research%20in%20neuroscience%20suggests,the%20root%20of%20the%20EQ.">studies have suggested</a> that reading fiction can increase empathy. But a perhaps <a href="https://www.tandfonline.com/doi/abs/10.1080/10400419.2013.783735#:~:text=Original%20Articles-,Opening%20the%20Closed%20Mind%3A%20The%20Effect%20of%20Exposure%20to,on%20the%20Need%20for%20Closure&amp;text=The%20need%20for%20cognitive%20closure,to%20decreased%20creativity%20and%20rationality">even more surprising finding</a> comes from researchers who discovered a short-term decrease in the need for “cognitive closure” in the minds of readers of fiction. In brief, the researchers write, those with a high need for cognitive closure “need to reach a quick conclusion in decision-making and an aversion to ambiguity and confusion,” and thus, when confronted with confusing circumstances, tend to seize on fast explanations and hang on to them. That generally means they’re more susceptible to things like conspiracy theories and poor information, and they become less rational in their thinking. Reading fiction, though, studies have found, tends to retrain the brain to stay open, comfortable with ambiguity, and able to sort through information more carefully.
</p>
<div class="c-float-right">
<aside id="7659oh">
<q>Reading fiction retrains the brain to stay open, comfortable with ambiguity, and able to sort through information more carefully</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yVK1N9">
These all sound like great reasons to develop a practice of reading. But how? The key, as with most everything in life, is to build a habit of reading. What you’re trying to do is practice sustained attention. Like any habit, the trick is in figuring out what works for you.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WABA0q">
There’s a bit of willpower involved, of course. “The hardest part about reading is actually picking the book up,” Lobash says, and we both laugh knowingly. To start reading, you have to sit down and pick up a book, or cue up an audiobook in your headphones. You’ll never become a reader by wishing you read more, listening exclusively to podcasts, or sitting next to a book while you scroll Instagram. (Even buying books doesn’t make you a reader, as I have, unfortunately, found out.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zEkgfk">
If money is tight (or even if it isn’t), libraries are stellar resources, with easy systems in place to borrow not just physical books but ebooks and audiobooks (through apps like Libby and Overdrive) — often without even having to go to the library. And there are ways to train yourself to read. “I always have a book next to wherever I put my phone,” Escoto tells me. “So if I have the urge to check my phone for another useless <a href="https://www.vox.com/the-goods/21547961/doomscrolling-meaning-definition-what-is-meme">doomscrolling</a> session, I physically can see the book there. Nine times out of 10, I will choose the book, because I know what’s in store for me if I get on my phone.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9rDNqB">
That kind of physical proximity, making it easy for yourself to read, is a great way to get back into the habit. Years ago, I had a colleague who would purchase cheap paperback copies of lengthy books he needed to read, and then he’d physically rip them down the spine and carry pieces of the book with him. I was horrified the first time I saw him do it, but I eventually came to realize it was his way of making sure that the heft or width of a book wouldn’t be a barrier to reading it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m77uFY">
Like Escoto, I prefer a paper book to an electronic one (and <a href="https://bigthink.com/neuropsych/reading-memory/">research suggests we remember what we read on paper better than ebooks</a>). Sometimes, though, I’ll purchase the electronic version just so I can tap open the app on long commutes and read it on whatever device is at hand. Not ideal, but it gets the job done. Don’t let the perfect be the enemy of the good.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dsEBml">
Another obvious barrier is time, and this is where audiobooks can be a godsend. “That is reading!” Escoto says. Audiobooks are great for occupying the mind while you’re commuting, washing dishes, mowing the lawn, or lifting at the gym. “Investigate other formats that are more comfortable for you so that it doesn’t feel like <em>I have to sit here and read</em>,” she says. And if you save particularly exciting or juicy books for particular activities — logging miles on the treadmill, for instance — then you train yourself to crave <em>both</em> activities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oSZFCr">
Sometimes the best way to make sure you read is to lean into whatever personality quirks you know you have, and make use of them. In the summer of 2020 — you remember that summer — I felt like I was both grasping for sanity and desperate to walk away from screens. I could barely sit still, let alone read a few pages without subconsciously picking up my phone. Yet I needed to read, because I was writing a book, and that required me to plow through dozens of books for research.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m8SLEd">
So I exploited my love of tasks and assignments. I made myself syllabi, determining which books I would read during which weeks. I’d count the number of chapters or pages in each book, divide them as evenly as possible into daily reading, and schedule those into my task list. Then I’d pair the day’s reading with my hammock or, later, a trip to the local beer garden.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3RCtif">
That’s just the way that worked for me. Others might decide to read while sipping morning coffee. Or, as Escoto points out, making reading a communal event can be helpful, whether through virtual or in-person reading groups (like <a href="https://www.vox.com/vox-book-club">Vox’s Book Club</a>), or just picking a book to read with a friend.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LVGrYR">
Whatever you need to do to reestablish a reading habit is a net benefit, and that should extend to what you read, too. That might require divorcing yourself from the notion that books have to be important or educational to be legitimate. “Just give yourself permission to read whatever you’re interested in reading,” Escoto says.
</p>
<div class="c-float-right">
<aside id="67x6eN">
<q>There’s no shame in rereading the books that made you fall in love with reading in the first place</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Liy8Nr">
If that doesn’t ring any bells, your Netflix queue might be a clue. “If someone came into a library, and I said, I don’t know, I don’t really like to read, it feels like a chore, I would ask them, ‘Well, what do you like to watch?’” Lobash says. “I think using other media is a really good doorway to finding something that you will like to read.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4fJ4g8">
An algorithm or a Google search might help you here, but both Lobash and Escoto emphatically remind me that librarians are probably your best resource. “A lot of what’s involved in librarianship is recommending books, and part of how we do that as professionals is to suss out what the person’s interested in,” Escoto says. Lobash echoes this, saying that librarians “know all the right questions to ask.” Plenty of adults come to the library with their children, she says, but it’s rarer for them to come for themselves — and they’re a resource that’s just waiting to be tapped. Booksellers at your local bookstore can fill the same function, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X12aOS">
And if you’re really stuck, but yearning to get back to your youthful reading bliss, maybe just revisit your old favorites, Escoto says. There’s no shame in rereading the books that made you fall in love with reading in the first place. If the science is right, then recreating that sustained attention is really what you’re after, at least as much as the stories themselves. Regaining the practice of reading is a little like hiking or playing an instrument or picking up painting: It takes some work to get in the groove, but once you do, the results are beautiful and immensely satisfying.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zcSGcd">
<a href="http://www.vox.com/even-better"><em>Even Better</em></a><em> is here to offer deeply sourced, actionable advice for helping you live a better life. Do you have a question on money and work; friends, family, and community; or personal growth and health? Send us your question by filling out this </em><a href="https://docs.google.com/forms/d/e/1FAIpQLSfiStGSlsWDBmglim7Dh1Y9Hy386rkeKGpfwF6BCjmgnZdqfQ/viewform"><em>form</em></a><em>. We might turn it into a story.</em>
</p></li>
<li><strong>Biden’s dismal poll numbers, explained in 9 charts</strong> -
<figure>
<img alt="President Biden Commemorates Passage Of The Bipartisan Safer Communities Act" src="https://cdn.vox-cdn.com/thumbor/i8NObIyeWbrC-B-oCW7QOrUvXgs=/0x0:5333x4000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71158039/1241842607.0.jpg"/>
<figcaption>
President Joe Biden speaks at the White House about the passage of gun violence legislation, on July 11. | Kent Nishimura/Los Angeles Times/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Much of it comes down to dissatisfaction with the economy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9N0FlB">
In recent months, Democrats have been increasingly concerned about President Joe <a href="https://fivethirtyeight.com/features/whats-behind-bidens-record-low-approval-rating/">Biden’s low approval rating</a>, fearing it will hurt their party in the 2022 midterms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6d1eQo">
As of mid-July, <a href="https://morningconsult.com/form/global-leader-approval/">survey</a> after <a href="https://docs.cdn.yougov.com/sdsvy1azjc/econTabReport.pdf">survey</a> has shown his approval ratings floundering amid <a href="https://www.cnbc.com/2022/07/18/bidens-economic-approval-rating-falls-to-new-low-on-fear-about-inflation-cnbc-survey-finds.html">dissatisfaction with his handling of the economy</a> and ongoing concerns about inflation and gas prices. To top it off, <a href="https://www.nytimes.com/2022/07/11/us/politics/biden-approval-polling-2024.html">a poll from the New York Times and Siena College</a> found that just 26 percent of Democrats thought he should be renominated in two years, while 64 percent would be open to someone else.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Oa3dlL">
The backlash that Biden is experiencing isn’t entirely unusual: Most presidents see some loss of support within their first two years. His approval ratings have fallen lower than those of his recent predecessors at the same point in their presidency, however, fueling worries that Biden’s unpopularity could weigh down Democrats this fall.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="At4vDC">
Here are nine charts that explain just how bad things are for Biden, and how bad they could be for his party.
</p>
<h3 id="NqjhPT">
Biden’s approval rating hit new lows this past month
</h3>
<div id="2VwmEz">
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Should Ronaldo’s stay or leave Manchester United?</strong> - Cristiano Ronaldo has not yet returned to preseason training with Manchester United because of what has been publicly described as “personal reasons”</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>De Bruyne at the double but Haaland kept waiting as Man City down America</strong> - Kevin De Bruyne’s double strike was enough to help Manchester City see off Club America 2-1 in Houston on Wednesday as Pep Guardiola made Erling Haaland wait for his debut</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Harika stays fully focused for the Chess Olympiad</strong> - Expectant mother training at home, away from teammates</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Talukdar, Dipti best among Indians in recurve</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bracewell hat-trick seals New Zealand T20 win over Ireland</strong> - Dane Cleaver’s 78 not out and Michael Bracewell’s hat-trick powered New Zealand to an 88-run win over Ireland in the second T20I.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Veteran Ayurveda practitioner Padmanabhan Vaidyar passes away</strong> - He set up Padma Pharmacy in 1958</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TRS members walk out of Lok Sabha</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TMC to abstain from vice presidential election: Abhishek</strong> - “We disagree with the process of announcing the Opposition candidate without keeping TMC in the loop.”</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Parents take home 129 wards from school</strong> - Building of primary school at Indur village in dilapidated condition</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra Pradesh: Second phase of ‘Srinivasa Setu’ project begins in Tirupati</strong> - Municipal Commissioner asks executing agency to complete the work in a month</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Italian PM Mario Draghi resigns after week of turmoil</strong> - He headed a unity government for 18 months, but three parties refused to back him in a key vote.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eurozone raises interest rates for first time in 11 years</strong> - The European Central Bank has raised rates as it tries to tackle soaring eurozone inflation.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nord Stream: Key Russian pipeline resumes pumping gas to Europe</strong> - There had been fears Moscow would not restart flows in response to sanctions over the Ukraine war.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Spanish bull run: Three dead in 24 hours in Valencia hospitals</strong> - The men had all been wounded recently during the Valencia region’s annual festival.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war has made my son want to be a soldier - Zelenska</strong> - Olena Zelenska is in the US where she raised the plight of other children in the conflict.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The USPS will buy a lot more electric next-gen delivery vans</strong> - The Postal Service will buy commercial off-the-shelf EVs as well as NGDVs. - <a href="https://arstechnica.com/?p=1868405">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dell’s XPS 13 Plus Developer Edition gets Ubuntu 22.04 LTS certified</strong> - Dell’s revamped XPS is the first laptop with 22.04 LTS certification. - <a href="https://arstechnica.com/?p=1868128">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amid infant formula disaster, Juul fiasco, FDA seeks outside review</strong> - The review will provide initial recommendations within 60 days, Califf said. - <a href="https://arstechnica.com/?p=1868387">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pro-Russia hacking campaigns are running rampant in Ukraine</strong> - Hacks also exploit critical Follina vulnerability and phishing campaigns. - <a href="https://arstechnica.com/?p=1868340">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>M2 MacBook Air teardown reveals accelerometer, minimal heat management</strong> - Plus, a peek at the new speaker system. - <a href="https://arstechnica.com/?p=1868182">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>12 atoms of sodium walk into a bar.</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Followed by Batman.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/cantab314"> /u/cantab314 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w4dj1a/12_atoms_of_sodium_walk_into_a_bar/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w4dj1a/12_atoms_of_sodium_walk_into_a_bar/">[comments]</a></span></p></li>
<li><strong>What do you call a woman who knows where her husband is at all times?</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A widow
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/PlatinumRaptor95"> /u/PlatinumRaptor95 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w3wj4w/what_do_you_call_a_woman_who_knows_where_her/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w3wj4w/what_do_you_call_a_woman_who_knows_where_her/">[comments]</a></span></p></li>
<li><strong>Can everyone in this sub please brighten my day up a bit? My parrot died last night.</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His last words were “Oh fuck, I think my parrot is dying!”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/LightsOn-NobodyHome5"> /u/LightsOn-NobodyHome5 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w3x9gu/can_everyone_in_this_sub_please_brighten_my_day/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w3x9gu/can_everyone_in_this_sub_please_brighten_my_day/">[comments]</a></span></p></li>
<li><strong>Last night I had a dream that I was eating a giant marshmallow</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
and when I woke up my giant marshmallow was gone.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/n_thomas74"> /u/n_thomas74 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w4749u/last_night_i_had_a_dream_that_i_was_eating_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w4749u/last_night_i_had_a_dream_that_i_was_eating_a/">[comments]</a></span></p></li>
<li><strong>I only believe 12.5% of the Bible</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I guess that makes me an eighth-theist
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Dutch_Midget"> /u/Dutch_Midget </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w3kff6/i_only_believe_125_of_the_bible/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w3kff6/i_only_believe_125_of_the_bible/">[comments]</a></span></p></li>
</ul>
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