navan
/
Daily-Dose
mirror of https://github.com/navanchauhan/Daily-Dose.git
1
0
Fork 0
Code Issues Projects Releases Wiki Activity

Added daily report

This commit is contained in:
Navan Chauhan 2021-06-23 12:47:54 +00:00
parent aa1bb13d15
commit f61358f082
3 changed files with 733 additions and 2 deletions
Show Stats Download Patch File Download Diff File Expand all files Collapse all files

231
archive-covid-19/23 June, 2021.html Normal file
View File

@ -0,0 +1,231 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>23 June, 2021</title>
<style type="text/css">
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
</style>
<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins</strong> -
<div>
Antiphospholipid antibodies (aPL), assumed to cause antiphospholipid syndrome (APS), are notorious for their heterogeneity and detect phospholipids and phospholipid-binding proteins. The persistent presence of Lupus anticoagulant and/or aPL against cardiolipin and/or {beta}2 glycoprotein I have been shown to be independent risk factors for vascular thrombosis and pregnancy morbidity in APS. Among others, viral infections have been proposed to trigger the production of aPL while mostly being considered non-pathogenic. Yet, the potential pathogenicity of infection-associated aPL has gained momentum since an increasing number of patients infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been described with coagulation abnormalities and hyperinflammation, together with the presence of aPL. Here, we present data from a multicentric, mixed-severity study including three cohorts of individuals who contracted SARS-CoV-2 as well as non-infected blood donors. We simultaneously measured 10 different criteria and non-criteria aPL (IgM and IgG) by using a line immunoassay. Further, IgG antibody response against three SARS-CoV-2 proteins was investigated using tripartite automated blood immunoassay technology. Our analyses revealed that select non-criteria aPL are enriched concomitant to or after an infection with SARS-CoV-2. Linear mixed-effect models suggest an association of aPL to prothrombin (PT) with the strength of the antibody response against SARS-CoV-2 and further influenced by SARS-CoV-2 disease severity and sex of the individuals. In conclusion, our study is the first to report an association between disease severity, anti-SARS-CoV-2 immunoreactivity and aPL against PT in patients with SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.21.449211v1" target="_blank">Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins</a>
</div></li>
<li><strong>Tools for Public Health Policy: Nudges and Boosts as Active Support of the Law in Special Situations such as the COVID-19 Pandemic</strong> -
<div>
In recent years, “nudging” has become a standard behavioral intervention at the individual level and for the design of social policies. Although nudges are effective, such interventions seem to be limited to a given space and time, and there is only scant evidence to support the contrary view. On the other hand, choice architects may utilize another type of intervention called “boosting,” which shows the promise of generalized and lasting behavioral change. The government can use these tools to shape public policy. Behavioral interventions such as policy-making tools have their boundaries, as does the law. We argue that nudging and boosting may serve as active aids in support of the legal system under certain circumstances. Nudging and boosting can also support the legal system especially in relation to emerging social issues or events that are unprecedented, such as the recent COVID-19 pandemic, where certain behavioral patterns are expected, but it would be hard or impossible to enforce them through the law alone.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/8sepk/" target="_blank">Tools for Public Health Policy: Nudges and Boosts as Active Support of the Law in Special Situations such as the COVID-19 Pandemic</a>
</div></li>
<li><strong>SequenceBouncer: A method to remove outlier entries from a multiple sequence alignment</strong> -
<div>
Phylogenetic analyses can take advantage of multiple sequence alignments as input. These alignments typically consist of homologous nucleic acid or protein sequences, and the inclusion of outlier or aberrant sequences can compromise downstream analyses. Here, I describe a program, SequenceBouncer, that uses the Shannon entropy values of alignment columns to identify and remove outlier entries in a manner responsive to overall alignment context. I demonstrate the utility of this software using alignments of mammalian reference mitochondrial genomes, bird cytochrome c oxidase-derived sequence barcodes, and COVID-19 sequences.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.24.395459v2" target="_blank">SequenceBouncer: A method to remove outlier entries from a multiple sequence alignment</a>
</div></li>
<li><strong>Adherance to Public Health Measures in Adolescents versus Adults duing the COVID-19 Pandemic in Canada</strong> -
<div>
To mitigate the burden of COVID-19 on healthcare systems and to reduce infections and associated deaths, public health measures including physical distancing and mask-wearing have been recommended. We know little regarding important predictors of adherence and motivation to engage in public guidelines among at-risk populations, such as adolescents. Objectives. The purpose of the present study was to examine differences in adherence to public health measures across provinces, and to examine developmental differences in both adherence and motivations to engage in public health among adolescents and adults across Canada during the COVID-19 pandemic. Methods. Participants from two samples, including adolescents (N=788, 56.7% female, M=15.68, SD=1.36) and adults (N=578, 94.6% female; M=45.12, SD=5.83) completed online quesionnaires during the summer 2020. Results. Both adolescents and adults in provinces mandating masks were more likely to wear a mask. There were no provincial differences in adherence to social distancing. Adolescents were more likely to be motivated by social reasons, while adults were motivated by social responsibility. For both adults and adoeslcents, social responsibility was associated with more adherence to public health measures, while social concerns(e.g., maintaining social ties, social judgment) was associated with less adherence. Conclusion. Adherence to public health measures was mixed, with most participants reporting socializing in-person with people outside of their home. At the time of the survey, provincial mask mandates were associated with more mask-wearing. Results also suggest social responsibility was the main predictor of increased adherence to public health measures.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/mxfz7/" target="_blank">Adherance to Public Health Measures in Adolescents versus Adults duing the COVID-19 Pandemic in Canada</a>
</div></li>
<li><strong>‘Phytopathological strolls’ in the dual context of COVID-19 lockdown and IYPH2020: transforming constraints into an opportunity for public education about plant pathogens</strong> -
<div>
The experience presented here relates to 2020, a particularly timely year for plant disease-related communication (‘International Year of Plant Health’ IYPH2020), but also a unique year because of the COVID-19 pandemic. Our goal was to illustrate the diversity and beauty of fungal plant pathogens through a naturalist approach that could be followed by any amateur. We achieved this end through ‘phytopathological strolls’, in which we observed and determined the origin of symptoms on diseased plants found in our garden, in the local streets, in nearby open spaces, and sharing this matter with a broad public. The lockdown imposed in France created an additional motivation to take up the challenge, and to involve our children, even under strong constraints, such as movement restrictions. We observed and described fungal pathogens through hundreds of photographs, shared our findings with a large audience on Twitter, and received feedback. The material used was deliberately simple and transportable: a digital reflex camera, an old microscope, a mobile phone, some books and an Internet connexion. Between March 17, 2020 and June 20, 2021 we found 196 plant pathogens, including 97 rusts, 27 powdery mildews and 28 septoria-like diseases. We discuss here the importance of promoting searches for plant pathogens, their description and conservation, through a combination of classical approaches and digital tools in tune with the times, such as Twitter, by treating pathogen identification like a detective game and, more surprisingly, by making use of the addictive nature of collection approaches, drawing a parallel with Pokemon Go.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.02.03.429201v2" target="_blank">‘Phytopathological strolls’ in the dual context of COVID-19 lockdown and IYPH2020: transforming constraints into an opportunity for public education about plant pathogens</a>
</div></li>
<li><strong>The Knowledge and Attitude of Physicians Regarding Vaccinations in Yerevan, Armenia: Challenges for COVID-19</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background This primary-data analysis investigates the current level of awareness and medical knowledge of physicians in 20 health facilities in Yerevan, Armenia regarding vaccination, specifically with regard to HPV infection and the recently-introduced Gardasil vaccine used against HPV infection that may have implications for successful roll-outs of national programmes for new vaccines, including those for COVID-19. Methods A questionnaire-based cross-sectional study was completed by 348 physicians who met the study inclusion criteria, from 20 out of 36 randomly selected healthcare facilities in Yerevan, Armenia, between Dec 2017 to Sep 2018. The aim of the questionnaire was to identify physicians awareness of and attitudes to HPV-related cervical cancer and the Gardasil vaccine. Responses were analysed using SPSS software (Version 16). Results The responding physicians displayed a respectable level of knowledge and awareness regarding vaccination with regard to some characteristics (e.g. more than 81% knew that HPV infection was commonly asymptomatic, 87% were knew that HPV infection was implicated in most cervical cancers and 87% knew that cervical cancer is the most prevalent cancer amongst women) but low knowledge in others and poor understanding of key issues such as the age at which women were most likely to develop cervical cancer (only 15% answered correctly); whether or not the vaccine should be administered to people who had already been affected (27% answered correctly) and whether sexually active young people should be treated for infection before vaccination (26%). Lack of confidence within the surveyed groups regarding the value of vaccination and, in particular concerns over the reasons for administering it to certain age cohorts, was driven by misconceptions. Conclusions Armenian physicians awareness of vaccine characteristics, the reasons for their inclusion in the national vaccination programme and the characteristics of the diseases they treat can be poor. The study further suggests that drivers of vaccine hesitancy are complex, may not be consistent from vaccine to vaccine, and may vary from generation to generation. The Armenian healthcare sector may need to provide additional training, awareness-raising and educational activities to improve understanding of and trust in vaccination programmes. Further studies are warranted to better understand knowledge, attitudes and practices (KAP) regarding immunization and vaccination programmes amongst Armenian healthcare workers.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.15.21258948v1" target="_blank">The Knowledge and Attitude of Physicians Regarding Vaccinations in Yerevan, Armenia: Challenges for COVID-19</a>
</div></li>
<li><strong>Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system</strong> -
<div>
With global vaccination efforts against SARS-CoV-2 underway, there is a need for rapid quantification methods for neutralizing antibodies elicited by vaccination and characterization of their strain dependence. Here, we describe a designed protein biosensor that enables sensitive and rapid detection of neutralizing antibodies against wild type and variant SARS-CoV-2 in serum samples. More generally, our thermodynamic coupling approach can better distinguish sample to sample differences in analyte binding affinity and abundance than traditional competition based assays.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.22.449355v1" target="_blank">Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system</a>
</div></li>
<li><strong>Cytoplasmic tail truncation of SARS-CoV-2 Spike protein enhances titer of pseudotyped vectors but masks the effect of the D614G mutation</strong> -
<div>
The high pathogenicity of SARS-CoV-2 requires it to be handled under biosafety level 3 conditions. Consequently, Spike protein pseudotyped vectors are a useful tool to study viral entry and its inhibition, with retroviral, lentiviral (LV) and vesicular stomatitis virus (VSV) vectors the most commonly used systems. Methods to increase the titer of such vectors commonly include concentration by ultracentrifugation and truncation of the Spike protein cytoplasmic tail. However, limited studies have examined whether such a modification also impacts the proteins function. Here, we optimized concentration methods for SARS-CoV-2 Spike pseudotyped VSV vectors, finding that tangential flow filtration produced vectors with more consistent titers than ultracentrifugation. We also examined the impact of Spike tail truncation on transduction of various cell types and sensitivity to convalescent serum neutralization. We found that tail truncation increased Spike incorporation into both LV and VSV vectors and resulted in enhanced titers, but had no impact on sensitivity to convalescent serum inhibition. In addition, we analyzed the effect of the D614G mutation, which became a dominant SARS-CoV-2 variant early in the pandemic. Our studies revealed that, similar to the tail truncation, D614G independently increases Spike incorporation and vector titers, but that this effect is masked by also including the cytoplasmic tail truncation. Therefore, the use of full-length Spike protein, combined with tangential flow filtration, is recommended as a method to generate high titer pseudotyped vectors that retain native Spike protein functions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.21.449352v1" target="_blank">Cytoplasmic tail truncation of SARS-CoV-2 Spike protein enhances titer of pseudotyped vectors but masks the effect of the D614G mutation</a>
</div></li>
<li><strong>Coverage and effectiveness of mRNA SARS-CoV-2 vaccines among United States Veterans</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Importance: The scope of vaccination rollout and effectiveness of mRNA SARS-CoV-2 vaccines in the United States (US), and US Veterans specifically, has not been fully assessed. Objective: To estimate receipt of SARS-CoV-2 vaccines, and vaccine effectiveness (VE) against SARS-CoV-2 infection, subsequent disease-related severity and mortality. Design, Setting, and Participants: First, receipt of any SARS-CoV-2 vaccine by March 7, 2021 was described for all enrolled and alive Veterans within the Veterans Health Administration (VHA). Second, to evaluate mRNA SARS-CoV-2 VE, a matched test negative case-control evaluation was conducted across all VHA facilities utilizing SARS-CoV-2 positive (cases [n=16,690]) and negative (controls [n=61,610]) tests from Veterans aged ≥18 years old who routinely sought care at a VHA facility and were tested for SARS-CoV-2 from December 14, 2020, through March 14, 2021. Exposures: Vaccination histories were obtained from pharmacy and medical records to determine if patients were unvaccinated, partially vaccinated (from 7 days after first dose until day of second dose of mRNA SARS-CoV-2 vaccine), or fully vaccinated (from 7 days after second dose of mRNA SARS-CoV-2 vaccine) at time of SARS-CoV-2 test. Main Outcome Measures: Primary outcomes were (1) vaccine receipt among Veterans and specific subpopulations, (2) VE calculated from odds ratios (ORs) with 95% confidence intervals (95% CI) for the association between SARS-CoV-2 infection and full vs. no vaccination, and (3) VE against infection for partial vs. no vaccination. VE against COVID-19-related hospitalization and death were also estimated. Results: By March 7, 2020, among 6,170,750 Veterans, 1,547,045 (23.1%) received at least one SARS-CoV-2 vaccine. Based on the analysis of mRNA SARS-CoV-2 vaccines, VE against infection was 93.7% (95% CI 92.0-95.0) and 57.7% (95% CI 53.5-61.5) for full and partial vaccination (vs. no vaccination), respectively. VE was similar for subpopulations. VE against COVID-19-related hospitalization and death for full vs. no vaccination was 90.7% (95% CI 90.0-91.3) and 94.7% (95% CI 91.3-98.1), respectively. Conclusion and Relevance: Vaccines are effective in reducing SARS-CoV-2 infections and disease-related severity and mortality in the Veteran population. Effective vaccine, as well as their efficient and equitable distribution, are important for reducing COVID-19 disease burden among Veterans.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.14.21258906v1" target="_blank">Coverage and effectiveness of mRNA SARS-CoV-2 vaccines among United States Veterans</a>
</div></li>
<li><strong>Recovery of deleted deep sequencing data sheds more light on the early Wuhan SARS-CoV-2 epidemic</strong> -
<div>
The origin and early spread of SARS-CoV-2 remains shrouded in mystery. Here I identify a data set containing SARS-CoV-2 sequences from early in the Wuhan epidemic that has been deleted from the NIH’s Sequence Read Archive. I recover the deleted files from the Google Cloud, and reconstruct partial sequences of 13 early epidemic viruses. Phylogenetic analysis of these sequences in the context of carefully annotated existing data suggests that the Huanan Seafood Market sequences that are the focus of the joint WHO-China report are not fully representative of the viruses in Wuhan early in the epidemic. Instead, the progenitor of known SARS-CoV-2 sequences likely contained three mutations relative to the market viruses that made it more similar to SARS-CoV-2’s bat coronavirus relatives.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.18.449051v1" target="_blank">Recovery of deleted deep sequencing data sheds more light on the early Wuhan SARS-CoV-2 epidemic</a>
</div></li>
<li><strong>Estimating Vaccination Effects on COVID-19 outbreak course in Japan</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Japan started vaccinations for COVID-19 in late February, 2021, mainly using BNT162b2 mRNA COVID-19 Vaccine. Object: We evaluated COVID-19 vaccination effects on infectiousness in Japan. Method: The effective reproduction number R(t) was regressed on vaccine coverage along with data of temperature, humidity, mobility, and countermeasures. We presumed two definitions for vaccine coverage: at least a single dose with a 12-day delay and a second dose. The study period was February, 2020 through May 16, 2021. Results: Estimation results indicate that vaccine coverage significantly and drastically reduced R(t) for both definitions. Results imply that increased first shot coverage by 1% point decreased R(t) by 0.5 with a 12 day delay. Moreover, increased second shot coverage by 1% point, decreased R(t) by 1 immediately. Discussion and Conclusion: Vaccination effects might be stronger because the periods when vaccination was started and rapid spread coincide with a decreasing phase of R(t).
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.20.21259209v1" target="_blank">Estimating Vaccination Effects on COVID-19 outbreak course in Japan</a>
</div></li>
<li><strong>Association between overcrowded households, multigenerational households, and COVID-19: a cohort study</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Introduction: The role of overcrowded and multigenerational households as a risk factor for COVID-19 remains unmeasured. The objective of this study is to examine and quantify the association between overcrowded and multigenerational households, and COVID-19 in New York City (NYC). Methods: We conducted a Bayesian ecological time series analysis at the ZIP Code Tabulation Area (ZCTA) level in NYC to assess whether ZCTAs with higher proportions of overcrowded (defined as proportion of estimated number of housing units with more than one occupant per room) and multigenerational households (defined as the estimated percentage of residences occupied by a grandparent and a grandchild less than 18 years of age) were independently associated with higher suspected COVID-19 case rates (from NYC Department of Health Syndromic Surveillance data for March 1 to 30, 2020). Our main measure was adjusted incidence rate ratio (IRR) of suspected COVID-19 cases per 10,000 population. Our final model controlled for ZCTA-level sociodemographic factors (median income, poverty status, White race, essential workers), prevalence of clinical conditions related to COVID-19 severity (obesity, hypertension, coronary heart disease, diabetes, asthma, smoking status, and chronic obstructive pulmonary disease), and spatial clustering. Results: 39,923 suspected COVID-19 cases presented to emergency departments across 173 ZCTAs in NYC. Adjusted COVID-19 case rates increased by 67% (IRR 1.67, 95% CI = 1.12, 2.52) in ZCTAs in quartile four (versus one) for percent overcrowdedness and increased by 77% (IRR 1.77, 95% CI = 1.11, 2.79) in quartile four (versus one) for percent living in multigenerational housing. Interaction between both exposures was not significant (βinteraction = 0.99, 95% CI: 0.99-1.00). Conclusions: Over-crowdedness and multigenerational housing are independent risk factors for suspected COVID-19. In the early phase of surge in COVID cases, social distancing measures that increase house-bound populations may inadvertently but temporarily increase SARS-CoV-2 transmission risk and COVID-19 disease in these populations.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.14.21258904v1" target="_blank">Association between overcrowded households, multigenerational households, and COVID-19: a cohort study</a>
</div></li>
<li><strong>Did social factors buffer against the effect of adversities on self-harm during the COVID-19 pandemic? A longitudinal analysis of 49,227 UK adults</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Little is known about which factors exacerbate and buffer the impact of COVID-19 -related adversities on changes in thinking about and engaging in self-harm over time. Aims: To examine how changes in four social factors contribute to changes in self-harm thoughts and behaviours over time and how these factors in turn interact with adversities and worries about adversities to increase risk for these outcomes. Method: Data from 49,227 UK adults in the UCL COVID-19 Social Study were analysed across the first 59 weeks of the pandemic. Fixed effects logistic regressions examined time-varying associations between social support quality, loneliness, number of days of face-to-face contact for &gt; 15 minutes, and number of days phoning/video calling for &gt;15 minutes with self-harm thoughts and behaviours. We then examined how these four factors in turn interacted with the total number of adversities and worries about adversity on outcomes. Results: Increases in the quality of social support decreased the likelihood of both outcomes, whilst greater loneliness increased their likelihood. Associations were inconsistent for telephone/video contact and face-to-face contact with outcomes. Social support buffered and loneliness exacerbated the impact of adversity experiences with self-harm behaviours. Other interactions were inconsistent, and some were in the unexpected direction. Conclusions: These findings suggest the importance of the quality of social support, rather than the mere presence of contact, is important for reducing the likelihood of self-harm behaviours in the context of COVID-19 pandemic-related adversity and worry.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.19.21259173v1" target="_blank">Did social factors buffer against the effect of adversities on self-harm during the COVID-19 pandemic? A longitudinal analysis of 49,227 UK adults</a>
</div></li>
<li><strong>An Extended Susceptible-Exposed-Infected-Recovered (SEIR) Model with Vaccination for Forecasting the COVID-19 Pandemic in Sri Lanka</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The role of modelling in predicting the spread of an epidemic is important for health planning and policies. This study aims to apply a compartmental model for predicting the variations of epidemiological parameters in Sri Lanka. We used a dynamic Susceptible-Exposed-Infected-Recovered-Vaccinated (SEIRV) model, and simulated for potential vaccine strategies under a range of epidemic conditions. The predictions were based on different vaccination coverages (5% to 90%), vaccination-rates (1%, 2%, 5%) and vaccine-efficacies (40%, 60%, 80%) under different R0 (2,4,6). We observed how the above dynamics influenced the SEIRV model without COVID-19 vaccination at different R0 values, and estimated the duration, exposed and infected populations. When the R0 was increased, the days of reduction of susceptibility and the days to reach the peak of the infection were reduced gradually. At least 45% vaccine coverage is required for reducing the infected population as early as possible. The results revealed that when R0 is increased in the SEIRV model along with the increase of vaccination efficacy and vaccination rate, the population to be vaccinated is reducing. Thus, the vaccination offers greater benefits to the local population by reducing the time to reach the peak, exposed and infected population through flattening the curves.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.17.21258837v1" target="_blank">An Extended Susceptible-Exposed-Infected-Recovered (SEIR) Model with Vaccination for Forecasting the COVID-19 Pandemic in Sri Lanka</a>
</div></li>
<li><strong>Continuous Positive Airway Pressure (CPAP) for Moderate to Severe Covid19 Acute Respiratory Distress Syndrome (CARDS) in a Resource limited setting</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Covid19 Acute Respiratory Distress Syndrome (CARDS) poses a challenge in management particularly due to limited capacity of ventilated intensive care beds and staffing, and this is exacerbated in resource poor settings with poor patient outcomes. Within this context CPAP has been trialled for CARDS although mainly in resource rich settings. This study retrospectively analyses the survival outcomes and characteristics of a cohort of patients with moderate to severe CARDS were treated exclusively with CPAP in a rural secondary level hospital in Pakistan with limited previous critical care expertise. 32 out of the 41 patients (78%) who were treated with CPAP survived overall (30/37 (81%) who were treated according to protocol), suggesting non inferiority to CARDS outcomes of critical care units employing Intubation and Mechanical Ventilation (IMV) in resource rich settings. This suggests CPAP should be promoted as an efficacious and cost-effective method for treating CARDS within the context of the pandemic surge of Covid19 in resource poor settings.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.17.21258809v1" target="_blank">Continuous Positive Airway Pressure (CPAP) for Moderate to Severe Covid19 Acute Respiratory Distress Syndrome (CARDS) in a Resource limited setting</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MP1032 Treatment in Patients With Moderate to Severe COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: MP1032;   Drug: Placebo<br/><b>Sponsors</b>:   MetrioPharm AG;   Syneos Health, LLC<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of XAV-19 for the Treatment of Moderate-to-severe COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: XAV-19;   Drug: Placebo<br/><b>Sponsor</b>:   Xenothera SAS<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Codivir in Patients With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Covidir injections;   Diagnostic Test: One Step Test;   Diagnostic Test: IgM and IgG dosage;   Diagnostic Test: RT-PCR SARS-CoV-2;   Diagnostic Test: Screening blood test;   Diagnostic Test: ECG;   Diagnostic Test: Medical evaluation;   Diagnostic Test: NEWS-2 score;   Diagnostic Test: WHO score<br/><b>Sponsors</b>:   Code Pharma;   Zion Medical<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Safety and Concentrations of Monoclonal Antibody Against Virus That Causes COVID-19 Disease.</strong> - <b>Condition</b>:   COVID-19 Virus Disease<br/><b>Interventions</b>:   Biological: MAD0004J08;   Other: Placebo<br/><b>Sponsors</b>:   Toscana Life Sciences Sviluppo s.r.l.;   Cross Research S.A.<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Vitamin C;   Drug: N-acetylcysteine (NAC);   Drug: NAC + Bromhexine (BMX)<br/><b>Sponsors</b>:   Universidade Federal do Ceara;   Paulista School of Medicine-EPM, UNIFESP;   Health Surveillance Secretariat - SVS;   Central Laboratory of Public Health of Ceara - LACEN-CE;   Leonardo da Vinci Hospital - HLV;   São José Hospital for Infectious Diseases - HSJ;   Ceará Health Secretariat - SESA;   Municipal Health Secretary - SMS-Fortaleza<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Osteopathic Manipulative Treatment (OMT)<br/><b>Sponsors</b>:   Western University of Health Sciences;   American College of Osteopathic Physicians;   American Osteopathic Foundation;   Osteopathic Physicians and Surgeons of California;   Xavier-Nichols Foundation<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of LNP-nCOV saRNA-02 Vaccine Against SARS-CoV-2, the Causative Agent of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: LNP-nCOV saRNA-02 Vaccine<br/><b>Sponsor</b>:   MRC/UVRI and LSHTM Uganda Research Unit<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ivermectin Treatment Efficacy in Covid-19 High Risk Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ivermectin 0.4mg/kg/day for 5 days<br/><b>Sponsor</b>:   Clinical Research Centre, Malaysia<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tolerability,Safety of JS016 in SARS-CoV-2 (COVID-19)</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2<br/><b>Intervention</b>:   Drug: Combination Product: JS016 (anti-SARS-CoV-2 monoclonal antibody)<br/><b>Sponsor</b>:   Peking Union Medical College Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Open Label, Single-Center Study Utilizing BIOZEK COVID-19 Antigen Rapid Test</strong> - <b>Condition</b>:   Covid-19 Testing<br/><b>Intervention</b>:   Diagnostic Test: Biozek Covid-19 Antigen Rapid Test (Saliva)<br/><b>Sponsor</b>:   Mach-E B.V.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In Situ Thrombolysis With tPA and Inflow Perfusion Analysis in Patient With Severe Covid-19 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: tPA<br/><b>Sponsor</b>:   Grupo Mexicano para el Estudio de la Medicina Intensiva<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cerebral Autoregulation and COVID-19</strong> - <b>Conditions</b>:   COVID-19 Acute Respiratory Distress Syndrome;   COVID-19 Pneumonia<br/><b>Intervention</b>:   Other: NIRS (Near-Infrared Spectroscopy)<br/><b>Sponsor</b>:   University of Athens<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Community-based Post-exposure Prophylaxis for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Guduchi Ghanvati;   Other: Standard guidelines<br/><b>Sponsors</b>:   NMP Medical Research Institute;   Aarogyam UK;   Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University;   Samta Ayurveda Prakoshtha, India;   Padmanabhama Ayurveda Hospital and Research Centre<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vitamin A Supplementation in Children With Moderate to Severe COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Dietary Supplement: Vitamin A supplement<br/><b>Sponsor</b>:   Shiraz University of Medical Sciences<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IRAK 4 Inhibitor (PF-06650833) in Hospitalized Patients With COVID-19 Pneumonia and Exuberant Inflammation.</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: PF-06650833;   Drug: Matching Placebo<br/><b>Sponsors</b>:   Giovanni Franchin, M.D, Ph.D;   Pfizer<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo</strong> - The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the recent global pandemic. The nuclear export protein (XPO1) has a direct role in the export of SARS-CoV proteins including ORF3b, ORF9b, and nucleocapsid. Inhibition of XPO1 induces anti-inflammatory, anti-viral, and antioxidant pathways. Selinexor is an FDA-approved XPO1 inhibitor. Through bioinformatics analysis, we predicted nuclear export sequences in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Integrated docking and enhanced sampling-based selection of repurposing drugs for SARS-CoV-2 by targeting host dependent factors</strong> - Since the onset of global pandemic, the most focused research currently in progress is the development of potential drug candidates and clinical trials of existing FDA approved drugs for other relevant diseases, in order to repurpose them for the COVID-19. At the same time, several high throughput screenings of drugs have been reported to inhibit the viral components during the early course of infection but with little proven efficacies. Here, we investigate the drug repurposing strategies to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals</strong> - Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Accordingly, compound-driven induction of autophagy limits SARS-CoV-2 propagation. In detail, SARS-CoV-2-infected cells show accumulation of key metabolites, activation of autophagy…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Design of optical cavity for air sanification through ultraviolet germicidal irradiation</strong> - The transmission of airborne pathogens represents a major threat to worldwide public health. Ultraviolet light irradiation can contribute to the sanification of air to reduce the pathogen transmission. We have designed a compact filter for airborne pathogen inactivation by means of UVC LED sources, whose effective irradiance is enhanced thanks to high reflective surfaces. We used ray-tracing and computational fluid dynamic simulations to model the device and to maximize the performance inside…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronaviruses, cholesterol and statins: Involvement and application for Covid-19</strong> - The infectious power of coronaviruses is dependent on cholesterol present in the membranes of their target cells. Indeed, the virus enters the infected cell either by fusion or by endocytosis, in both cases involving cholesterol-enriched membrane microdomains. These membrane domains can be disorganized in-vitro by various cholesterol-altering agents, including statins that inhibit cell cholesterol biosynthesis. As a consequence, numerous cell physiology processes, such as signaling cascades, can…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential for the Repurposing of Adamantane Antivirals for COVID-19</strong> - Several adamantanes have established actions against coronaviruses. Amantadine, rimantadine, bananins and the structurally related memantine are effective against human respiratory coronavirus HCoV-OC43, bovine coronavirus and severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and a spiroadamantane amine is effective against the coronavirus strain 229E. Molecular docking studies suggest that amantadine may block the viral E protein channel, leading to impaired viral propagation….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virtual screenings of the bioactive constituents of tea, prickly chaff, catechu, lemon, black pepper, and synthetic compounds with the main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE 2) of SARS-CoV-2</strong> - CONCLUSION: Therefore, the selected compounds could be considered a potential herbal treatment source against SARS-CoV-2.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies</strong> - Bruton’s tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR). Targeting of BTK with small molecule inhibitors has proven to be efficacious in several B cell malignancies. Interestingly, recent studies reveal increased BTK protein expression in circulating resting B cells of patients with systemic autoimmune disease (AID) compared with healthy controls. Moreover, BTK…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring the Psychological Effects of COVID-19 Home Confinement in China: A Psycho-Linguistic Analysis on Weibo Data Pool</strong> - CONCLUSION: Home confinement caused a decline in the use of positive emotion words. This indicates that home confinement can increase the frequency of negative emotions. The changes of exclusion words and inhibition words in high-endemic areas may be related to the high epidemic threat and the urgent need for social distancing in these areas.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of New Potent anti-MERS CoV Fusion Inhibitors</strong> - Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its HR1 binding site. We designed eleven peptides with stronger estimated HR1 binding affinities than the wild-type peptide to prevent viral fusion with the cell membrane. Eight peptides showed strong…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“Surfactants - compounds for inactivation of SARS-CoV-2 and other enveloped viruses”</strong> - We provide here a general view on the interactions of surfactants with viruses, with a particular emphasis on how such interactions can be controlled and employed, for inhibiting the infectivity of enveloped viruses, including coronaviruses. The aim is to provide to interested scientists from different fields, including chemistry, physics, biochemistry, and medicine, an overview over the basic properties of surfactants and (corona)viruses, which are relevant to understanding the interactions…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19: In silico identification of potent alpha-ketoamide inhibitors targeting the main protease of the SARS-CoV-2</strong> - The COVID-19 has been creating a global crisis, causing countless deaths and unbearable panic. Despite the progress made in the development of the vaccine, there is an urge need for the discovery of antivirals that may better work at different stages of SARS-CoV-2 reproduction. The main protease (M^(pro)) of the SARS-CoV-2 is a crucial therapeutic target due to its critical function in virus replication. The α-ketoamide derivatives represent an important class of inhibitors against the M^(pro)…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fragment-based in silico design of SARS CoV-2 main protease inhibitors</strong> - 3CLpro is essential for SARS-CoV-2 replication and infection; its inhibition using small molecules is a potential therapeutic strategy. In this study, a comprehensive crystallography-guided fragment-based drug discovery approach was employed to design new inhibitors for SARS-CoV-2 3CLpro. All small molecules co-crystallized with SARS-CoV-2 3CLpro with structures deposited in the Protein Data Bank were used as inputs. Fragments sitting in the binding pocket (87) were grouped into eight…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors</strong> - The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global pandemic coronavirus disease (COVID-19), but no specific antiviral drug has been proven effective for controlling this pandemic to date. In this study, several 2-((indol-3-yl)thio)-N-benzyl-acetamides were identified as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors. After a two-round optimization, a new series of 2-((indol-3-yl)thio)-N-benzyl-acetamides was designed, synthesized,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial</strong> - BACKGROUND: The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental and early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary capillary leak.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 anti-viral therapeutic</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU327160071">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>폐마스크 밀봉 회수기</strong> - 본 발명은 마스크 착용 후 버려지는 일회용 폐마스크를 비닐봉지에 넣은 후 밀봉하여 배출함으로써, 2차 감염을 예방하고 일반 생활폐기물과 선별 분리 배출하여 환경오염을 방지하는 데 그 목적이 있다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR325788342">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COST EFFECTIVE PORTABLE OXYGEN CONCENTRATOR FOR COVID-19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU324964715">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA)</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323956811">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Erweiterbare Desinfektionsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Erweiterbare Desinfektionsvorrichtung, umfassend: einen Hauptkörper, der eine umgekehrt U-förmige Basisplatte aufweist, wobei die umgekehrt U-förmige Basisplatte mit einer Öffnung versehen ist und jeweils eine Seitenplatte sich von zwei Seiten der umgekehrt U-förmigen Basisplatte nach außen erstreckt; und mindestens eine Desinfektionslampe, die in den auf zwei Seiten des Hauptkörpers befindlichen Seitenplatten angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402480">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Einfache Sterilisationsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Einfache Sterilisationsvorrichtung, mit einem Hauptkörper (11), der in Längsrichtung einen ersten Plattenabschnitt (111) und in Querrichtung einen zweiten Plattenabschnitt (112) aufweist, wobei der erste Plattenabschnitt (111) und der zweite Plattenabschnitt (112) L-förmig miteinander verbunden sind; und einer Sterilisationslampe (12), die an dem Hauptkörper (11) angeordnet ist und eine Lichtemissionseinheit (121), eine Sensoreinheit (122), eine Steuereinheit (123) und eine Stromeinheit (124) aufweist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402479">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Klemmarme aufweisende Desinfektionsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Klemmarme aufweisende Desinfektionsvorrichtung, umfassend: einen Hauptkörper; eine Desinfektionslampe, die im Hauptkörper angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst; einen Klemmabschnitt, der auf einer Seite des Hauptkörpers angeordnet ist, wobei der Klemmabschnitt zwei gegenüberliegende Greifbacken umfasst, wobei mindestens eine der beiden Greifbacken mit einer Schwenkachse versehen ist, wobei ein Klemmraum durch passgenaues Schließen der beiden Greifbacken entsteht und die beiden Greifbacken jeweils mit einem Durchgangsloch versehen sind; einen Befestigungsabschnitt, der durch die Durchgangslöcher der beiden Greifbacken hindurchgeführt ist;und ein Schild, das auf einer Seite des Klemmabschnitts angeordnet und mit einem Aufnahmeloch versehen ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402478">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aufhängbare Sterilisationsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Aufhängbare Sterilisationsvorrichtung, mit einem Hauptkörper (11); einer Sterilisationslampe (12), die an dem Hauptkörper (11) angeordnet ist und eine Lichtemissionseinheit (121), eine Sensoreinheit (122), eine Steuereinheit (123) und eine Stromeinheit (124) aufweist; einem Klemmabschnitt (13), der an einer Seite des Hautpkörpers (11) angeordnet ist und zwei gegenüberliegend angeordnete Klemmbacken (131) aufweist, wobei mindestens eine der beiden Klemmbacken (131) mit einem Achsbolzen (132) versehen ist, wobei die beiden Klemmbacken (131) beim Schließen einen Klemmraum (134) bilden, und wobei die beiden Klemmbacken (131) jeweils mit einem Durchgangsloch (135) versehen sind; und einem Befestigungselement (14), das durch die Durchgangslöcher (135) der beiden Klemmbacken (131) hindurchgeführt wird.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402477">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sterilisationsvorrichtung zur Verbesserung der Desinfektionswirkung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Sterilisationsvorrichtung zur Verbesserung der Desinfektionswirkung, umfassend: einen Hauptkörper, der eine erste Oberfläche, eine von der ersten Oberfläche abgewandte zweite Oberfläche und ein Aufnahmeloch aufweist, wobei die zwei Seiten des Hauptkörpers jeweils mit einem Durchgangsloch versehen sind, wobei die Durchgangslöcher mit dem Aufnahmeloch durchgängig verbunden sind; eine Desinfektionslampe, die auf der zweiten Oberfläche des Hauptkörpers angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst; und ein Befestigungsteil, das durch die Durchgangslöcher und das Aufnahmeloch des Hauptkörpers hindurchgeführt ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402481">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295937">link</a></p></li>
</ul>
<script>AOS.init();</script></body></html>

500
archive-daily-dose/23 June, 2021.html Normal file
View File

@ -0,0 +1,500 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>23 June, 2021</title>
<style type="text/css">
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
</style>
<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How a Conservative Activist Invented the Conflict Over Critical Race Theory</strong> - To Christopher Rufo, a term for a school of legal scholarship looked like the perfect weapon. - <a href="https://www.newyorker.com/news/annals-of-inquiry/how-a-conservative-activist-invented-the-conflict-over-critical-race-theory">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Joe Biden Just Had a Summit with Vladimir Putin and Nothing Crazy Happened</strong> - The triumph of Geneva is that it was not Helsinki. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/joe-biden-just-had-a-summit-with-vladimir-putin-and-nothing-crazy-happened">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What Is Going On at Yale Law School?</strong> - The prestigious institution has tied itself in knots over a dispute involving one of its most popular—and controversial—professors, Amy Chua. - <a href="https://www.newyorker.com/news/annals-of-education/what-is-going-on-at-yale-law-school">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Delta Variant Is a Grave Danger to the Unvaccinated</strong> - One half of America is protected. The other is approaching a perilous moment in the pandemic. - <a href="https://www.newyorker.com/science/medical-dispatch/the-delta-variant-is-a-grave-danger-to-the-unvaccinated">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Politics of Supreme Court Retirements</strong> - Amid calls for Justice Stephen Breyer to step down, the legal scholar Noah Feldman considers politics, partisanship, and the Court. - <a href="https://www.newyorker.com/news/q-and-a/the-politics-of-supreme-court-retirements">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Reevaluating the gay bar</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/gkczaRFnSE-p1pCLCOUs046gOO4=/290x0:2617x1745/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69492078/GettyImages_1298899770.0.jpg"/>
<figcaption>
People dance at a gay bar, The Swallow, during White Center, Seattle, Pride weekend in 2019. | San Francisco Chronicle/Hearst Newspapers via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After a pandemic year, it felt like nothing had changed. But I had.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UtifV9">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GZOSXI">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FAbNsu">
Unmasked and hyper-aware of the midnight crowd swelling around me, I felt my heart suddenly beating too fast. Partly, I was still getting used to breathing indoor air,<strong> </strong>to being around people at all. But being back inside one of my frequent gay haunts also felt somehow sour-sweet, like the Cuervo and soda I gripped too tight. My head seemed to float above me like a helium balloon; I imagined a smiley face scrawled across it in magic marker. I was happy, after all — wasn’t I?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CLCvlS">
Two drinks in and my back was still glued to the wall. I watched the mostly white men flowing in both directions and wondered if they’d noticed me, my dense black beard and almond skin, and what they saw. This time last year, I’d been cutting my hair over the bathroom sink; I’d forgotten the unmoored feeling of being assessed, or worse, overlooked. After the third drink, I was wedged tight into a steamy stampede of bodies, dislodging myself into a familiar blur. I kissed a guy I had kissed many times before, and another I had met for just 10 minutes, unimaginable only weeks prior.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1c2i7C">
I fumbled conversations with strangers, felt the cold trickle of a drink spilled down my back, and waited my turn to pee. By the time I burst into the early morning air to bike the 20 blocks home, I was relieved to be alone again — and aware that I had already taken a night out for granted.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f1akPw">
It’s Pride month after a devastating year of isolation and loss. The pandemic has wreaked <a href="https://www.hrc.org/resources/research-on-lgbtq-people-and-the-covid19-pandemic">disproportionate havoc</a> on LGBTQ+ people, who have been more likely to face bad health outcomes, economic hardship, and <a href="https://elemental.medium.com/covid-19-is-wreaking-havoc-on-lgbtq-mental-health-641a3a99725">mental health strain</a> as a result of Covid-19 and the preventive measures that forced us apart.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uvjbJi">
Now, we’re meant to be making up for lost time, and June being our prescribed month for social and political unity, it’s supposed to mean something. Some people continued clandestine gatherings all along, as <a href="https://www.nytimes.com/2021/03/07/business/media/the-drunken-canal-media-nyc.html">style pages whispered</a>, while others were <a href="https://www.them.us/story/gaysovercovid-instagram-public-shaming-gay-civil-war-op-ed">dragged on social media</a> for doing so openly. But secrets and shame are the opposite of Pride. This month was going to be different.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wWnZGt">
But lonely, and sometimes desperate, as lockdown and quarantine had been, I had also felt a secret measure of relief, escaping the microscope that can hover over many queer spaces. In the absence of social pressures — about my skin color, my body, my clothes, or whether I was having the best possible time — I leaned into <a href="https://www.them.us/story/self-acceptance-in-quarantine">everything underneath all that</a> and asked myself who I am and what I actually want.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ne1VjZ">
It’s thrilling to feel too-loud beats thunder through my Converse soles again, to fill my senses with other men. But I know now that what I once went out in search of isn’t just around the next corner, crouched in the blue-tinted dark. I wasn’t going to feel any less alone in a crush of people until I could sit with myself and accept what I found.
</p>
<hr class="p-entry-hr" id="i8IZG2"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pxhLZz">
There’s a reason the movement for queer liberation was galvanized at San Francisco’s Compton’s Cafeteria and the Stonewall Inn in Manhattan. Gays, lesbians, and particularly Black and brown trans women, couldn’t find refuge, livelihood, or each other, outside all-night diners and basement bars. Their identities and behavior criminalized, some pursued survival sex work. They flocked to the only spaces where they could be themselves, meet acceptance, and escape violence. Until violence was thrust upon them by police, and they fought, fiercely, for themselves, their right to be together, and, whether or not they knew it at the time, for us.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lz4R36">
I recognize how fortunate I’ve been not to have faced fear for my well-being, harassment, or worse beyond playground bullying. I first stumbled onto Pride, <a href="https://www.refinery29.com/en-us/2016/06/114804/gay-pride-after-orlando-shooting">on the last Sunday in June</a> nearly two decades ago, and felt the euphoria of diving into a sea of queer revelers; I didn’t come to outrun<strong> </strong>any physical threat to my safety. Still, I had never felt such a sprawling connection to other queer people than I did that day, despite being too young to follow any of them into a bar.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zroxky">
When I eventually found my way onto the dance floor, the joy of camaraderie fused with a need to feel desired. It was a hunger young and eager enough not to recognize that the attention I craved and received was mostly from white men. I valued my otherness only insofar as they demonstrated its worth, with an approving look, touch, or invitation. I understood Pride in concept, but needed physical proof, however false, that I shouldn’t feel ashamed of not resembling the <a href="https://www.them.us/story/queer-poc-body-image">men culture taught me to idealize</a>, chiseled and white like carved stone.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XoLf9j">
Considering the significance of watering holes to queer liberation, what I’ve looked for inside them all these years can feel comparably shallow, even if it’s partly what they’ve always been for: to feel seen, perhaps even admired. To drink and dance and escape. To touch and connect and actually feel connected. To seek sex and maybe, impossibly, intimacy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5eBJiS">
In the months (and months) when no such experiences were possible, I would often submerge as deep as possible into my too-small, bath-bombed tub, heat curving around my body. Turned-up beats echoed off the tiled walls, flooding my dim-lit bathroom with the ache and defiance of SZA, Rihanna, and Fiona.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FQ2rYZ">
I thought about how absurd it was that I had ever sought such a thoroughly cocooned feeling in a club, looking to others as a source of warmth and assurance, one I couldn’t control down to the degree. I wondered what all of those people were doing at that moment, and if they felt as alone at the end of their ropes as I did. I cried more than once, curled up and dripping on the toilet lid to phone a friend.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B3A5BN">
On nights when I was forced to think about what I missed most about being out, I began to realize that I had been searching, sometimes frantically and with a misguided exuberance, for not just community but the sort of love and validation that only I can give myself. I wanted men to assure me that I deserve attention and pleasure and respect. I wanted to seem like I already knew as much, but the fact is I often didn’t.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V70btj">
The scrutinies that cis gay men pile onto each other have for some <a href="https://www.them.us/story/gay-bi-racism-looks-grindr-anxiety-depression">surpassed discrimination from outside the community</a> as the main drivers of anxiety and depression. As we’ve gained greater social acceptance from the dominant culture, the pressures that gay and bi men, in particular, aim at our own — including racism and a <a href="https://www.them.us/story/queer-poc-body-image">fixation on body image</a>, status, and sex — are making many of us quietly miserable. Black, Asian, and other men of color, as well as those who don’t fit masculine body ideals or are disabled, are disproportionately impacted by poor mental health outcomes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BMxwyL">
What started as essential safe havens for acceptance and connection have also become fertile ground for posturing and exclusion, sown by our own shame. But if we’ve learned anything over the past year, I hope it is to question, at every opportunity, who is included in the “we” that is meant to express community among LGBTQ+ people. The impossible standards that gay and bi men foist on each other have never felt more privileged and myopic. Their psychological impacts, like the alienation I’ve felt pressed against the perspiring wall of a mostly white club, are real.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AxgkHM">
But the past year has also renewed my gratitude for all of life’s basic needs — health, safety, employment, shelter — everything our movement was founded on fighting for, from within those very bars. Those of us who are fortunate enough to enjoy all of those essentials have a responsibility to stand up and fight for those who don’t.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XPyYve">
Having witnessed how the least advantaged among us suffered most from the pandemic, and having woken up, god willing, to the pervasiveness of white supremacy and anti-Black racism in every aspect of culture and society, I hope we’re ready to treat each other with more kindness and compassion. To put our wallets and our necks and our livelihoods on the line to demand justice for Black trans lives. To embrace and uplift anyone who has shown up at Pride, in a big city or rural town, and felt safety and acceptance for the first time.
</p>
<hr class="p-entry-hr" id="bDz6ui"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="phD2qL">
On a closed-off avenue the following weekend, a half dozen queer girls no older than I was at my first Pride gingerly shook their limbs into a mini dance circle. On a side street, aspiring music acts took the stage in front of a diffuse and diverse crowd. Brooklyn Pride brought an afternoon street fair to Park Slope, skateboards rattling against the pavement, vibrant, fresh dye jobs glinting in the sun. A group of friends stood around grazing pizza from the box, each in a different-colored cowboy hat from Party City, the paper bag still in tow.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VpUiwS">
Later that night I ducked into the nearby bar Good Judy, where a Black femme in a color-block jumpsuit checked my vaccination status. Just inside, two girls were selling beaded bracelets with phrases like “bb dyke” and “she/them” strung together in blue and pink. A dance floor beyond the bar teemed with a mix of 20-somethings going wild for music released when I was their age, already tinged with nostalgia. I snaked my way into the middle intending to join them, but kept going through the back door when I felt the cool air of the courtyard.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="we2pWI">
I had already befriended a boyish Southerner, who towered above me in heels and produced for me a beer from his backpack (“I adore you,” he said). An older woman with cropped hair asked to borrow his tiara and turned to pose with no fewer than 15 of her friends. She looked like the spitting image of Olivia Coleman. He stooped down to take their picture, a flash illuminating the night air. I smiled up at the dark and wondered how I was ever going to get home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fjEnpK">
<em>Naveen Kumar is a culture critic and journalist whose recent work appears on Them and the Daily Beast. Follow him on Twitter </em><a href="https://twitter.com/Mr_NaveenKumar"><em><span class="citation" data-cites="Mr_NaveenKumar">@Mr_NaveenKumar</span></em></a><em>.</em>
</p></li>
<li><strong>China is buying Muslim leaders’ silence on the Uyghurs</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/WulWi4_fVMqOitfsCvkztu_fC6k=/333x0:3000x2000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69492033/GettyImages_1229679526_copy.0.jpg"/>
<figcaption>
Pakistan’s Prime Minister Imran Khan speaks during a press conference on November 19, 2020. | Wakil Kohsar/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Pakistani Prime Minister Imran Khan’s Axios interview is another example of this worrying trend.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wx0gDN">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UnwPYv">
As the world increasingly speaks out against <a href="https://www.vox.com/future-perfect/22311356/china-uyghur-birthrate-sterilization-genocide">China’s genocide of Uyghur Muslims in Xinjiang</a>, the quietest voices continue to belong to the leaders of Muslim-majority countries.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b5xdBt">
Look no further than <a href="https://www.youtube.com/watch?v=YlHPEgE3fjk">Pakistani Prime Minister Imran Khan’s interview this week with Axios’s Jonathan Swan</a>. Swan asked why the premier, who often speaks out on <a href="https://www.france24.com/en/live-news/20201028-pakistan-s-khan-calls-for-collective-muslim-action-against-islamophobia">Islamophobia in the West</a>, has been noticeably silent on the human rights atrocities happening just across his country’s border.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hV7nLD">
Khan parroted China’s denial that it has placed roughly <a href="https://www.vox.com/2021/1/19/22238962/china-genocide-uighur-muslims-xinjiang-biden-pompeo">2 million Uyghurs in internment camps</a> and then evaded the issue over and over again. “This is not the case, according to them,” Khan said, adding that any disagreements between Pakistan and China are hashed out privately.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fhOB5Z">
That’s a jarring statement. Instead of offering a pro forma “Yes, of course we’re concerned by this” before moving on, Khan chose instead to minimize the problem altogether.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QX9nJi">
Why would Khan do such a thing during a high-profile interview, with his self-enhanced image as a defender of Muslims on the line? The prime minister gave the game away later in the interview: “China has been one of the greatest friends to us in our most difficult times, when we were really struggling,” Khan told Swan. “When our economy was struggling, China came to our rescue.”
</p>
<div id="VtxPnd">
<div style="width: 100%; height: 0; padding-bottom: 56.25%;">
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UZZsaz">
<a href="https://www.politico.eu/article/pakistan-learns-cost-of-economic-alliance-with-china/">China has given Pakistan billions in loans</a> to prop up its economy, allowing the country to improve transit systems and a failing electrical grid, among other things. China didn’t do that out of the goodness of its heart; it did so partly to make Pakistan dependent on China, thus strong-arming it into a closer bilateral relationship.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QWqkum">
It’s a play China has run over and over through its “<a href="https://www.ebrd.com/what-we-do/belt-and-road/overview.html">Belt and Road Initiative</a>.” China aims to build a large land-and-sea trading network connecting much of Asia to Europe, Africa, and beyond. To do that, it makes investment and loan deals with nations on that “road” — like Pakistan — so that they form part of the network. The trade, in effect, is that China increases its power and influence while other countries get the economic assistance they need.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xVn3G2">
That relationship has helped Pakistan avoid economic calamity. But as of right now, it doesn’t have the funds to pay China back. That could spell trouble for Pakistan, as China has a history of taking a nation’s assets when it doesn’t pay its debts, like when it <a href="https://www.nytimes.com/2018/06/25/world/asia/china-sri-lanka-port.html">took over a Sri Lankan port in 2018</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2iNR9g">
To avoid a similar fate, and perhaps keep the money flowing, Khan likely didn’t want to badmouth China in public. “China is Pakistan’s only lifeline out of debt,” said Sameer Lalwani, director of the South Asia program at the Stimson Center in Washington, DC.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mULpPs">
Look elsewhere in the world and the story is essentially the same. Even the leaders of Iran, Saudi Arabia, and Turkey — who often portray themselves as the <a href="https://english.alarabiya.net/in-translation/2020/10/28/Is-Erdogan-sincere-in-his-declared-sentiments-to-defend-Islam-">defenders of Islam</a> and of the ummah, the global Muslim community — are choosing to prioritize their economic relationship with China over standing up for the Uyghurs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cM8rMK">
In the short term, they may get more funds from the relationship with China, but in the long run, the price they pay is in their reputation.
</p>
<h3 id="qZ0q4T">
China is buying Muslim leaders’ silence on the Uyghurs
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3xm3n1">
George Mason University’s Jonathan Hoffman, who studies Middle Eastern politics and geopolitical competition, told me Khan’s statements are in line with the trend of Muslim leaders turning away from China’s gross human rights abuses.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ppIpDD">
They “represent a broader pattern in the region where the plight of the Uyghurs is sidelined as China has quickly become the largest oil consumer, trade partner, and investor,” he told me.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ecMX71">
That helps explain some of the actions by Muslim-majority nations and their leaders in recent years, which Hoffman wrote about in May for the <a href="https://www.washingtonpost.com/politics/2021/05/04/why-do-some-muslim-majority-countries-support-chinas-crackdown-muslims/">Washington Post</a>:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WCjhEe">
In <a href="https://www.nytimes.com/2019/07/12/world/asia/china-human-rights-united-nations.html">2019</a>, Saudi Arabia, the United Arab Emirates and Egypt were among 37 countries that signed a <a href="https://ap.ohchr.org/Documents/E/HRC/c_gov/A_HRC_41_G_17.DOCX">letter</a> to the U.N. Human Rights Council praising China’s “contribution to the international human rights cause” — with claims that China restored “safety and security” after facing “terrorism, separatism and extremism” in Xinjiang…
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Vbcuw">
When Saudi Crown Prince Mohammed bin Salman <a href="https://nationalinterest.org/blog/buzz/either-you-are-us-or-against-us-gulf-states-caught-between-america-and-china-162741">visited</a> China in 2019, he declared that “China has the right to take anti‐terrorism and de‐extremism measures to safeguard national security.” And a <a href="https://www.oic-oci.org/docdown/?docID=4447&amp;refID=1250">March 2019 statement</a> by the Saudi‐based Organization of Islamic Cooperation (OIC) <a href="https://www.hrw.org/news/2019/03/21/missed-opportunity-protect-muslims-china">praised China</a> for “providing care to its Muslim citizens.”
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Vte7gP">
The most egregious example of how China has bought loyalty, compliance, and silence, though, may be Turkish President Recep Tayyip Erdoğan.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/reoG3w9I1zLmb2jPmGLad6TU_m0=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22675360/GettyImages_1154857596_copy.jpg"/> <cite>Greg Baker/AFP/Getty Images</cite>
<figcaption>
Uyghur men walk toward a mosque to attend Eid al-Fitr prayers, marking the end of Ramadan, in China’s Xinjiang region in 2019.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zd9dKI">
In 2009 — as Chinese authorities cracked down on Uyghurs amid ethnic violence in Xinjiang, and long before there were credible reports of arbitrary imprisonment, torture, and forced labor — the Turkish leader spoke out about what was happening.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P0AKIX">
“The incidents in China are, simply put, a genocide. There’s no point in interpreting this otherwise,” <a href="https://www.reuters.com/article/us-turkey-china-sb/turkish-leader-calls-xinjiang-killings-genocide-idUSTRE56957D20090710">Erdoğan said</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EgGA7x">
But now his tune has changed. In January, <a href="https://www.voanews.com/east-asia-pacific/turkey-cracks-down-uighur-protesters-after-china-complains">Turkish police broke up a protest led by local Uyghurs outside China’s consulate in Istanbul</a>, and the government stands accused of <a href="https://www.businessinsider.com/turkey-accused-of-extraditing-uighur-muslims-for-china-coronavirus-vaccine-2021-1">extraditing Uyghurs to China in exchange for Covid-19 vaccines</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sHaGIQ">
Why such a shift? You guessed it: Money.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JrPpsF">
The <a href="https://www.worldbank.org/en/news/press-release/2021/04/27/economic-rebound-in-turkey-could-be-impacted-by-domestic-macroeconomic-volatility-and-evolving-global-uncertainties">Turkish economy was in a downturn</a> well before the coronavirus pandemic, but China has come to the rescue. Erdoğan and his team have sought <a href="https://www.trtworld.com/turkey/chinese-bank-to-loan-3-6-billion-to-turkey-19186">billions from China</a> in recent years, and China became the <a href="https://foreignpolicy.com/2021/03/02/why-erdogan-has-abandoned-the-uyghurs/">largest importer of Turkish goods in 2020</a>. Saying anything negative about the Chinese government — especially on the Uyghur issue — could sever the financial lifeline China provides.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SzMToO">
That said, the pressure from the pro-Uyghur public in Turkey has forced a slight shift in the Erdoğan regime’s rhetoric in recent months. In March, <a href="https://www.aljazeera.com/news/2021/3/25/turkey-says-conveyed-sensitivity-about-uighurs-to-china">Turkish Foreign Minister Mevlut Cavusoglu</a> said his administration has brought up the plight of the Uyghurs in private discussions with Chinese officials.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PltHcB">
Still, that falls far short of what the world should expect from Muslim leaders.
</p></li>
<li><strong>Tokyo’s Olympic Village will be very vaccinated</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/FmSoqQVrTvHF6OGObQVq3JF5h5o=/188x0:2855x2000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69491966/GettyImages_1312243674.0.jpg"/>
<figcaption>
Malaysian athletes and officials receive their Pfizer/BioNTech Covid-19 vaccine on April 13, 2021. | Annice Lyn/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The IOC estimates that well above 80 percent of athletes will have their shots. But with unequal vaccination access globally, the preparations are raising yet another debate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G0Vssc">
Some <a href="https://www.nejm.org/doi/full/10.1056/NEJMp2108567">15,000 Olympians and Paralympians</a> from more than 200 countries, along with thousands of coaches and support staff, are heading to Japan for the Tokyo Olympic and Paralympic Games, which kick off in July.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kg6NxG">
And it’s looking like the games will be a pretty vaccinated place, according to the International Olympic Committee (IOC).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IBVuZ3">
In a statement to Vox, an IOC spokesperson said that “well above” 80 percent of residents of the Olympic and Paralympic Village in Tokyo will be vaccinated, and somewhere between 70 and 80 percent of the media.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1uq62q">
Yet those figures are a reminder of the risks and realities of holding an Olympics when a pandemic is very much still raging and vaccine access is so <a href="https://www.vox.com/future-perfect/22440986/covax-challenges-covid-19-vaccines-global-inequity">severely limited in many parts of the world</a>.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/uRjg8k8A585BVU6ncK20nszekMU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22674952/GettyImages_1232884041.jpg"/> <cite>Wagner Meier/Getty Images</cite>
<figcaption>
Brazilian athlete and swimmer Larissa de Oliveira receives the first dose of the Pfizer/BioNTech Covid-19 vaccine in Rio de Janeiro on May 14, 2021.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KsySt4">
Only about 22 percent of the globe’s population has received their first shot, <a href="https://ourworldindata.org/covid-vaccinations">the vast majority in higher-income countries</a>. Japan’s vaccination campaign, after a sluggish start, is now inoculating about <a href="https://www.npr.org/2021/06/21/1008672209/tokyo-olympics-will-open-its-doors-to-a-small-fan-base-covid-permitting">1 million people a day</a>. But that won’t be even close enough to get everyone <a href="https://english.kyodonews.net/news/2021/06/2a604f8d0710-japans-covid-19-vaccinations-for-under-65s-get-into-full-swing.html">under 65 jabbed by the time the Olympic ceremonies start</a> in late July.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l6W5k1">
Given the scale of the vaccination need globally and the world’s race against the clock to <a href="https://www.vox.com/22537118/covid-19-variants-alpha-beta-delta-gamma">stave off new variants</a>, the effort invested in the Olympics can seem a bit misplaced. Then again, despite calls for the games to be canceled,<strong> </strong><a href="https://www.vox.com/22428596/olympics-tokyo-2021">the Olympics<em> </em>are going ahead</a>, and vaccination is the best tool available to reduce the Covid-19 risks for participants, staff, and volunteers, and the people in Japan.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xb1BpV">
Which is why it makes sense to make sure everyone going to the Tokyo Olympics has their shot at, well, a shot.
</p>
<h3 id="NoRfAM">
What’s at stake in Tokyo
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FqKFr0">
A lot is riding on the Tokyo Games.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0r7zQ9">
They’re already the <a href="https://apnews.com/article/tokyo-coronavirus-pandemic-2020-tokyo-olympics-japan-olympic-games-3c46bce81928865d9aae0832b5ddd9e3">most expensive Olympic Games on record</a> at more than $25 billion, with a couple extra billion added on due to the<strong> </strong>one-year pandemic delay. Business and media interests have huge stakes in these games going ahead as planned. Japanese <a href="https://www.vox.com/21525743/japan-suga-yoshihide-prime-minister-coronavirus-economy">Prime Minister Suga Yoshihide’</a>s ability to successfully host the Olympics is seen as a political test of his handling of the pandemic. And this is really the last chance to host the 2020 Games: There will be no postponing it another year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I9tFx0">
For all of these reasons, the Japanese government and the IOC are heavily invested in making sure the games happen, and<strong> </strong>they’ve promised the games will be “safe and secure.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hnNFMc">
Foreign fans are banned from attending, but officials on Monday said local spectators will be allowed, <a href="https://www.nytimes.com/live/2021/06/21/world/covid-vaccine-coronavirus-mask#tokyo-olympics-spectators">with venues limited to 50 percent capacity, or up to 10,000 fans</a> — all of whom must follow Covid-19 protocols including mask-wearing and, somehow, <a href="https://www.msn.com/en-us/sports/other/olympics-will-allow-fans-despite-doctor-recommendations-but-loud-cheering-will-be-prohibited/ar-AALhdIN?li=BB15ms5q">no loud cheering</a>. The decision to let fans attend may change if Japan sees another coronavirus spike, although <a href="https://covid19.who.int/region/wpro/country/jp">cases have declined since a peak in May</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yv0iPz">
Athletes and other participants must also follow strict protocols — mask-wearing, social distancing, avoiding public transport — as officials attempt to create a version of a “<a href="https://www.vox.com/22428596/olympics-tokyo-2021">bubble</a>.” Athletes will have to detail their daily activities and get tested regularly (including follow-up testing <a href="https://www.insidethegames.biz/articles/1106741/ioc-false-positives-tokyo-2020-covid">in case of false positives</a>). Breaking these rules could potentially <a href="https://www.washingtonpost.com/sports/2021/06/15/tokyo-olympics-coronavirus-rules-penalties/">lead to disqualification or deportation</a>, much in the same way a positive Covid-19 test might.
</p>
<div class="c-wide-block">
<div class="c-image-grid">
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/L0Oi_32UlB3J-YOUIyyjYwtOTWo=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22674962/GettyImages_1233574619.jpg"/> <cite>Charly Triballeau/AFP via Getty Images</cite>
<figcaption>
People walk in the street in Tokyo’s Shimbashi area on June 21, 2021, after Japan announced the lifting of the city’s virus state of emergency just over a month before the Olympics.
</figcaption>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/pz8cocMqgy6zhRHfElohM6SdyrU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22674963/GettyImages_1233571464.jpg"/> <cite>Kazuhiro Nogi/AFP via Getty Images</cite>
<figcaption>
The National Stadium will be the main venue for the 2020 Olympic and Paralympic Games in Tokyo.
</figcaption>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/E7Ym-WblzbUETXxmvNMB3_2R_js=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22674964/GettyImages_1233571230.jpg"/> <cite>Jinhee Lee/SOPA Images/LightRocket via Getty Images</cite>
<figcaption>
Plastic shields are installed in gyms as a preventative measure against infections inside the Olympic and Paralympic Village in Tokyo.
</figcaption>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/25biSx-awXxKo52CM4axkcpNMh0=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22674966/GettyImages_1324529382.jpg"/> <cite>Takashi Aoyama/Getty Images</cite>
<figcaption>
Protesters gather during a media tour of the Olympic and Paralympic Village in Tokyo on June 20, 2021.
</figcaption>
</figure>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bprnQb">
Yet many Japanese people and public health experts are <a href="https://www.vox.com/22428596/olympics-tokyo-2021">still concerned</a> that the games will become a “superspreader” event, with people bringing variants from all corners of the world or taking the virus with them when they leave. The risks are not just to the attendees, but to those in Tokyo and the rest of Japan, whose health care systems may be left dealing with a surge in the wake of the Olympics.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="alG72U">
To further mitigate that risk — and <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fwww.telegraph.co.uk%2Folympics%2F2021%2F01%2F22%2Fexclusive-ioc-plan-vaccinate-every-olympic-athlete-save-tokyo%2F&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2F22537506%2Ftokyo-2021-olympics-vaccinations" rel="sponsored nofollow noopener" target="_blank">save the games</a> — the IOC in January <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fwww.telegraph.co.uk%2Folympics%2F2021%2F01%2F22%2Fexclusive-ioc-plan-vaccinate-every-olympic-athlete-save-tokyo%2F&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2F22537506%2Ftokyo-2021-olympics-vaccinations" rel="sponsored nofollow noopener" target="_blank">launched</a> an effort to work with the World Health Organization to get all Olympic athletes vaccinated in time, though <a href="https://www.usatoday.com/story/sports/olympics/2021/04/14/tokyo-olympics-covid-19-protocols-vaccine-plan/7218258002/">they’re not going so far as to mandate vaccinations</a> before the competitors arrive in Tokyo. As the Telegraph reported, part of that plan involved accelerating Covid-19 shots for athletes in countries that had yet to roll out their vaccination campaigns.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zn342j">
In May, the IOC <a href="https://www.businesswire.com/news/home/20210506005580/en/">announced</a> an agreement with Pfizer/BioNTech to distribute vaccine doses to athletes and delegates from participating countries. In an emailed statement, Pfizer’s Keanna Ghazvini, a senior associate for global media relations, said Pfizer/BioNTech and the IOC have made “meaningful progress” and anticipate that “more than 20 countries, where the necessary regulatory and legal conditions exist, will commit to the vaccination program.” In addition, there are efforts “to establish central locations where delegations from countries where the Pfizer/BioNTech Covid-19 vaccine is not yet available can go to be vaccinated ahead of traveling to Japan.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sT4B64">
<a href="https://www.japantimes.co.jp/news/2021/06/18/national/tokyo-olympics-vaccinations/">Tokyo officials have also begun</a> to inoculate local staff and members of the media who will be covering the Olympics, with the goal of vaccinating about 2,500 people per day. Earlier in June, Tokyo 2020 President Seiko Hashimoto <a href="https://www.dw.com/en/coronavirus-digest-japan-to-vaccinate-volunteers-and-journalists-at-olympics-amid-warning/a-57809957">said</a> about 70,000 of Tokyo’s volunteers and staff would be able to start getting vaccinated, though <a href="https://www.cnn.com/2021/06/03/sport/tokyo-olympics-volunteers-covid-intl-hnk/index.html">thousands of volunteers have already quit</a> over Covid-19 safety concerns. In a statement, the IOC said Japan had <a href="https://www.japantimes.co.jp/news/2021/06/18/national/tokyo-olympics-vaccinations/">secured an additional 40,000 doses from Pfizer/BioNTech</a> to vaccinate Olympic workers. Japan also started vaccinating its athletes at the beginning of June, with the goal of <a href="https://www.japantimes.co.jp/sports/2021/06/03/olympics/summer-olympics/japan-vaccinate-athletes/">vaccinating 95 percent of people on its teams</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FD4c1U">
Of course, athletes in places such as the United States can easily get a shot, though the US Olympic and Paralympic Committee (USOPC) didn’t require vaccinations for its delegation either. The USOPC, which did not return a request for comment, previously <a href="https://www.desertsun.com/videos/sports/2021/04/14/usopc-not-mandate-vaccines-olympians/7217417002/">said</a> it wouldn’t track vaccination rates among athletes. But in some sports, vaccination rates are quite high: USA Swimming, for example, said <a href="https://www.washingtonpost.com/sports/olympics/2021/06/18/michael-andrew-new-olympian-doubters-scrutiny/">at least 90 percent of its team is vaccinated</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZKQEWt">
Elsewhere, some countries committed to vaccinating their Olympic athletes in the early days of their rollouts. <a href="https://www.reuters.com/article/us-health-coronavirus-hungary-olympians/hungary-serbia-inoculate-olympic-athletes-ignoring-ioc-disapproval-idUSKBN29Y0ZZ">Hungary</a> began inoculating its Tokyo 2020 (and Beijing 2022) athletes in January. Israel, which launched one of the fastest vaccination campaigns in the world, <a href="https://asia.nikkei.com/Spotlight/Tokyo-2020-Olympics/Israel-to-vaccinate-all-athletes-for-Tokyo-Olympics-by-May">promised all competitors would have a shot by May</a>. Even Mexico, whose vaccine campaign has been less than stellar, still <a href="https://www.insidethegames.biz/articles/1104424/mexico-tokyo-2020-athletes-vaccine-group">put Olympians among its priority groups.</a> And as of early this month, India — which is emerging from a brutal coronavirus wave — <a href="https://indianexpress.com/article/sports/sport-others/india-tokyo-olympics-athletes-covid-19-vaccine-second-dose-update-7348167/">said dozens of its Olympic athletes and other attendees had been fully vaccinated</a>, with many more having received their first dose.
</p>
<h3 id="xoVKP0">
So, is it all worth it?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lfFm1T">
If the IOC estimates are correct, it looks like vaccination rates among Olympic participants will be high.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oejDbH">
That’s certainly a good thing for the Olympics — but zoom out, and the rest of the world is still very much dealing with the pandemic. Vaccine access around the world is deeply unequal, particularly when it comes to high-income versus low-income countries. About 85 percent of the world’s shots have gone to people in high- or upper-middle-income countries, compared to 0.3 percent of doses in low-income countries, <a href="https://www.nytimes.com/interactive/2021/world/covid-vaccinations-tracker.html">according to the New York Times</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t3qBVS">
It can feel disjointed to devote all of these efforts to vaccinate Olympic athletes and their entourages just so the games can go on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JAs36v">
But barring something extraordinary, the Olympics are<em> </em>happening. And experts said it makes more sense to adapt to this reality and ensure they’re as safe as possible — and that means prioritizing vaccinations.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/1nv052EKJdqBdwzbvNYIZa9niMQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22674970/GettyImages_1302600464.jpg"/> <cite>Du Xiaoyi-Pool/Getty Images</cite>
<figcaption>
The International Olympic Committee, the International Paralympic Committee, and the Tokyo 2020 Organizing Committee hold a press briefing on February 17, 2021, to discuss their countermeasures against Covid-19.
</figcaption>
</figure>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/jNjeFZvUdbv2_goZ4ODJGDlnORo=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22674971/GettyImages_1233593307.jpg"/> <cite>Charly Triballeau/AFP via Getty Images</cite>
<figcaption>
The countdown clock for the Tokyo Olympic Games is displayed on June 22, 2021, 30 days before the opening ceremony.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cDaynY">
Arthur Caplan, a professor of bioethics at New York University, said that, overall, the number of Olympic athletes and volunteers is relatively tiny when viewed on a global scale, and doesn’t amount to a huge diversion of vaccine supply. But there are going to be vulnerable people present in Tokyo, and that’s why he said all involved — from coaches to staff to food handlers — should get vaccinated immediately, especially as the time window for a two-dose regiment is about to close.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tK7Bf3">
Maybe Olympic athletes don’t fit squarely into our definition of essential workers. But if we see the Olympics as having cultural and international significance —<strong> </strong>and surely someone does if we’re trying to pull them off in a pandemic — then investing equitably in all Olympians and attendees is the best option. It would be far more glaringly unequal if teams from the US or Europe showed up fully vaccinated while teams from Africa or Latin America did not.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yXTvmG">
“These athletes that come from poor countries are citizens of the world,” Caplan said. “And that’s what we’re promoting — world citizenship. And that’s why they’re getting vaccinated.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hngKDS">
I reached out to a few US Olympic and Paralympic athletes, and some athletes said getting the vaccine was the best way to protect themselves, and the best hope to compete in Tokyo. But some saw it in bigger terms, too — viewing it as their responsibility as both travelers and public figures.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ApiS8v">
“As a global citizen, it’s the best way that I can help to make the pandemic end sooner,” Kyra Condie, <a href="https://www.kyracondie.com/">a climber who’ll be representing the US in Tokyo</a>, told me via voice memo. High-profile Olympians getting vaccines and winning gold medals after they do so could also <a href="https://www.vox.com/2021/6/2/22463223/covid-19-vaccine-hesitancy-reasons-why">ease some vaccine hesitancy</a>, especially among young and healthy people.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iv6d8w">
Inevitably, Covid-19 will still cause some disruptions to the games. Not all competitors will be vaccinated, <a href="https://www.washingtonpost.com/sports/olympics/2021/06/18/michael-andrew-new-olympian-doubters-scrutiny/">and that includes some who are publicly skeptical</a> and who also have a big platform. And <a href="https://nymag.com/intelligencer/2021/05/what-really-happened-with-that-weird-yankees-covid-outbreak.html">as the New York Yankees could tell you</a>, vaccines aren’t a perfect barrier against Covid-19, and they aren’t designed to be. Just this week, a member of the Ugandan Olympic team <a href="https://www.theguardian.com/sport/2021/jun/20/uganda-olympic-athlete-arriving-in-tokyo-tests-positive-for-coronavirus">tested positive for Covid-19 after arriving in Japan</a>. He, like the rest of his Olympic team, was fully vaccinated.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wD7Jx4">
The pandemic isn’t over, and these strange, year-late Olympics will remind us of that. But they could also offer a bit of a break from it. As Tara Kirk Sell, a senior scholar at the Johns Hopkins Center for Health Security at the Bloomberg School of Public Health and an Olympic medalist, put it, the Olympics can be seen as a “beacon of hope.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KWGhob">
“I think that it shows us where we’re headed,” she said, “and how we can come together as a global community.”
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>WTC final | Pant soldiers on as New Zealand restrict India to 130/5 at lunch</strong> - India lost Virat Kohli, Cheteshwar Pujara and Ajinkya Rahane in the morning session</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jadeja displaces Holder as top Test all-rounder</strong> - Jadeja is two points ahead of Holder (384) while England all-rounder Ben Stokes is third on 377 points.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vaughan, Pietersen slam possibility of families not travelling with England players for the Ashes</strong> - According to a report in the U.K. media, there is still uncertainty whether families of the visiting England players will be permitted to stay with them during the Ashes, beginning December 8.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ankita bows out of Wimbledon tennis Qualifiers</strong> - Ankita, ranked 182, had only one break point in the match, which she failed to convert.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kobe Bryant’s widow to settle lawsuit over deadly crash</strong> - If approved by the court, the settlement would end a negligence and wrongful death lawsuit filed against the estate of the pilot and the owner and operator of the helicopter that crashed into a hillside on January 26, 2020.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rahul Gandhi may appear before Gujarat court in defamation case on June 24</strong> - Purnesh Modi had filed a complaint against Rahul Gandhi in April 2019 under IPC sections 499 and 500 that deal with defamation.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Maharashtra tribal artists to be compensated for missing paintings</strong> - Paintings worth ₹20.79 lakh displayed at an exhibition in Malaysia in 2018 were allegedly lost</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Maharashtra government announces wage hike, COVID-19 allowance for Asha workers</strong> - After the announcement, Asha workers withdrew their week-long protest which they had launched in support of various demands, including a wage hike.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Construction of road should not result in destruction of biodiversity: NGT</strong> - ‘There can be no doubt that water bodies, wetlands, mangroves and other natural resources need to be protected’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid-19 | Caution remains the best weapon against possible third wave, say doctors in Kolkata</strong> - Masks and micro-containment essential; preparation should be on war footing, they say.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UK denies Russia fired warning shots near British warship</strong> - The Ministry of Defence says no shots were directed at HMS Defender and no bombs dropped in her path.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hungary PM ‘scraps Euros visit’ amid German LGBT row with Uefa</strong> - The decision comes amid anger that Uefa will not allow the Munich stadium to light up in rainbow colours.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Missing Italian toddler found by reporter sent to cover disappearance</strong> - The 21-month-old boy was found after a reporter covering his disappearance heard noises near a road.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eight on trial for burglaries on Paris celebrities</strong> - The gang is suspected of targeting the Paris homes of stars including footballer Thiago Silva.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: EU citizens given 28-day deadline to apply to stay in UK</strong> - The Home Office says people with a reasonable excuse for a delay can complete their forms later.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google Photos is so 2020—welcome to the world of self-hosted photo management</strong> - Google offers many desirable, easy-to-use, effective features. Going open source is trickier. - <a href="https://arstechnica.com/?p=1774386">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>24,000 years on ice weren’t enough to kill</strong> - Ancient species may re-enter the ecosystem as the world’s permafrost thaws. - <a href="https://arstechnica.com/?p=1775475">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Climate-driven coastal flooding in the US likely to get worse suddenly</strong> - Within a few decades, many areas of the US may see a rapid change in frequency. - <a href="https://arstechnica.com/?p=1775463">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Xbox cloud upgrade is live: Series X power on your browser for over 260 games</strong> - Game Pass Ultimate’s $15/mo now goes a lot further, and we break down why. - <a href="https://arstechnica.com/?p=1775411">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Once-dreaded Alpha variant is falling fast—Delta and Gamma take over</strong> - The Delta coronavirus variant now accounts for 20.6 percent of cases in the US. - <a href="https://arstechnica.com/?p=1775434">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Would anyone be interested in being my companion?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Asking for a friend
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/BoredBanana8"> /u/BoredBanana8 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o6055h/would_anyone_be_interested_in_being_my_companion/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o6055h/would_anyone_be_interested_in_being_my_companion/">[comments]</a></span></p></li>
<li><strong>A little boy asks his mom, “Why do women have balloons on their chest?”</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His mom responds, “So when we die we can easily float up to heaven.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Then aunt sally must really want to go to heaven.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“What do you mean?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Well, the other day she had her balloons out and daddy was blowing them up and she was saying ‘God, I’m coming.’”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/tutank21"> /u/tutank21 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o67130/a_little_boy_asks_his_mom_why_do_women_have/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o67130/a_little_boy_asks_his_mom_why_do_women_have/">[comments]</a></span></p></li>
<li><strong>The dirtiest joke my Grandma ever told me.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A mother puts her two sons to bed, before they fall asleep.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The older brother tells his little brother, “I think it’s time we started cussing.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The younger brother asks, “Well what are you going to say?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The older brother responds, “I’ll say, Hell.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The younger brother says, “Okay, I’ll say ass.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The next morning the mother asks her oldest son, “What do you want for breakfast?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He proudly tells his mother, “Oh, Hell I’ll have some Corn Flakes.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
So, she slaps him, then asks her younger son, “What do you want?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He adamantly responds, You bet your ass it’s not Corn Flakes!"
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
RIP Grandma, love you.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/BigC6977"> /u/BigC6977 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o63ela/the_dirtiest_joke_my_grandma_ever_told_me/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o63ela/the_dirtiest_joke_my_grandma_ever_told_me/">[comments]</a></span></p></li>
<li><strong>I opened a bar for men with erectile dysfunction.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It was a total flop. Nobody came
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/OwenJthomas89"> /u/OwenJthomas89 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o5lz6v/i_opened_a_bar_for_men_with_erectile_dysfunction/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o5lz6v/i_opened_a_bar_for_men_with_erectile_dysfunction/">[comments]</a></span></p></li>
<li><strong>3 reasons Jesus was actually Irish</strong> - <!-- SC_OFF -->
<div class="md">
<ol>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He went out drinking with his buddies the night before he died.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He thought his mother was a virgin.
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His mother thought he was God.
</li>
</ol>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Strange_Fruit_007"> /u/Strange_Fruit_007 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o61bq4/3_reasons_jesus_was_actually_irish/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o61bq4/3_reasons_jesus_was_actually_irish/">[comments]</a></span></p></li>
</ul>
<script>AOS.init();</script></body></html>

4
index.html
View File

File diff suppressed because one or more lines are too long