diff --git a/archive-covid-19/13 March, 2021.html b/archive-covid-19/13 March, 2021.html new file mode 100644 index 0000000..2c69ad8 --- /dev/null +++ b/archive-covid-19/13 March, 2021.html @@ -0,0 +1,218 @@ + +
+ + + ++“No-shows”, defined as missed appointments or late cancellations, is a central problem in healthcare systems. It has appeared to intensify during the COVID-19 pandemic and the nonpharmaceutical interventions, such as closures, taken to slow its spread. No-shows interfere with patients9 continuous care, lead to inefficient utilization of medical resources, and increase healthcare costs. We present a comprehensive analysis of no-shows for breast imaging appointments made during 2020 in a large medical network in Israel. We applied advanced machine learning methods to provide insights into novel and known predictors. Additionally, we employed causal inference methodology to infer the effect of closures on no-shows, after accounting for confounding biases, and demonstrate the superiority of adversarial balancing over inverse probability weighting in correcting these biases. Our results imply that a patient9s perceived risk of cancer and the COVID-19 time-based factors are major predictors. Further, we reveal that closures impact patients over 60, but not patients undergoing advanced diagnostic examinations. +
++In this paper, we develop a method that can detect and predict the emergence of new cases of COVID-19 at an early stage. With this method, we try to lay the empirical basis for the development of the model of digital monitoring and prediction of the occurrence of new cases of COVID-19 in Croatia, relying on the analytical tool Google Trends (GT). Results: In Croatia search activities using GT for terms such as “PCR +Covid”, “PCR + test”, and symptoms “cough + corona”, “pneumonia + corona”; “muscle pain + corona” correlate strongly with officially reported cases of the disease. Google Trends tools are suitable for predicting the emergence of new COVID-19 cases in Croatia, and that the data collected by this method correlate with official data. The benefit of this method is reliable estimates that can enable public health officials to prepare and better respond to the possible return of a pandemic in certain parts of the country. If a region experiences an early, sharp increase in Covid-19-like-illness Google searches, it may be possible to focus additional resources on that region to identify the etiology of the outbreak, providing extra medical capacity or raising local media awareness as necessary. Because the relative frequency of certain queries is highly correlated with the percentage of physician visits in which a patient presents with Covid-19 symptoms, this method can serve as an early alarm to predict the emergence of new cases of COVID-19 in the specific area in Croatia. +
++COVID-19 vaccine was launched in India on 16 January 2021, prioritizing health care workers which included medical students. We aimed to assess vaccine hesitancy and factors related to it among undergraduate medical students in India. An online questionnaire was filled by 1068 medical students across 22 states and union territories of India from 2 February to 7 March 2021. Vaccine hesitancy was found among 10.6%. Concern regarding vaccine safety and efficacy, hurried testing of vaccines prior to launch and lack of trust in government agencies predicted COVID-19 vaccine hesitancy. Risk perception regarding contracting COVID-19 vaccine reduced COVID-19 vaccine hesitancy as well as hesitation in participating in COVID-19 vaccine trials. Choosing between the two available vaccines (Covishield and Covaxin) was considered important by medical students both for themselves and their future patients. Covishield was preferred to Covaxin by students. Majority of those willing to take the COVID-19 vaccine felt that it was important for them to resume their clinical posting, face-to-face classes and get their personal life back on track. Around three-fourths medical students viewed that COVID-19 vaccine should be made mandatory for both health care workers and international travellers. Prior adult vaccination did not have an effect upon COVID-19 vaccine hesitancy. Targeted awareness campaigns, regulatory oversight of vaccine trials and public release of safety and efficacy data and trust building activities could further reduce COVID-19 vaccine hesitancy among medical students. +
++Objective: Clinical sequelae have not been well characterized during the post-acute phase of SARS-CoV-2 among adults 18 to 65 years old, and this study sought to fill that gap by evaluating excess risk and relative hazards for developing incident clinical sequelae during the post-acute phase. Design: Retrospective cohort study including three propensity-matched groups. Setting: This study merged three data sources from a large United States health plan: a large national administrative claims database, an outpatient lab testing database, and an inpatient hospital admissions database. Participants: Individuals 18 to 65 years old with continuous health plan enrollment from January 2019 to date of SARS-CoV-2 diagnosis. Three comparator groups were identified and propensity-score matched to individuals infected with SARS-CoV-2: a 2020 comparator group, a historical 2019 comparator group and a historical comparator group with viral lower respiratory tract illness (vLRTI). Main outcome measures: Over 50 clinical sequelae during the post-acute phase (index date + 21 days) were ascertained using ICD-10 codes. Excess risk due to SARS-CoV-2 during the 4 months following the acute phase of illness and hazard ratios with 95% Bonferroni-corrected confidence intervals were calculated. Results: This study found 14% of adults ≤65 years of age who were infected with SARS-CoV-2 (n=193113) had at least one new clinical sequelae that required medical attention during the post-acute phase of illness. When considering risk for specific sequelae attributable to SARS-Cov-2 infection during the post-acute phase, clinical outcomes including chronic respiratory failure, cardiac arrythmia, hypercoagulability, encephalopathy, peripheral neuropathy, amnesia (memory difficulty), diabetes, liver test abnormalities, myocarditis, anxiety and fatigue were significantly elevated compared to the three propensity-matched comparator groups (2020, 2019, vLRTI). Significant risk differences due to SARS-CoV-2 infection ranged from 0.02 to 2.26 per 100 people and hazard ratios ranged from 1.24 to 25.65 when compared to the 2020 comparator group. Conclusions: Our results confirm excess risk for developing clinical sequelae due to SARS-CoV-2 during the post-acute phase, including specific types of sequelae less commonly seen among other viral illnesses. Although individuals who were older, had pre-existing conditions, and were hospitalized due to COVID-19 were at greatest excess risk, younger adults (≤50 years), adults who did not have pre-existing conditions or adults who were not hospitalized due to COVID-19 were still at elevated risk for developing new clinical sequelae. The elevated risk for incident sequelae during the post-acute phase is relevant for healthcare planning. +
++The implementation of Non Pharmaceutical Interventions (NPI), triggered by the emergence of covid-19, decrease the RSV circulation. Data, from our ongoing surveillance; show a late introduction of RSV at the end of December and a 4 month delayed epidemic start without significant change in our NPI policy. This data indicates that RSV still have the potential to give a late season outbreak in northern hemisphere. RSV surveillance should be reinforced and RSV Pharmaceutical Interventions maintained for at risk neonate. +
++Objectives Despite concerns about the impact of the severe acute respiratory syndrome corona virus (Sars-CoV-2) in refugee camps, data on attack rates and effectiveness of containment measures are lacking. We aimed to (1) quantify the attack rate of Sars-CoV-2 during outbreaks in reception and accommodation centres in Germany, (2) assess differences in the attack rate based on containment measures, and (3) provide an overview of testing strategies, communication, conflicts, and protection measures for refugees with special needs. Methods Systematic web-based review of outbreak media reports (until June 2020) on confirmed Sars-CoV-2 cases in reception centers for asylum seekers in Germany using the google search engine. Reports were screened for pre-defined inclusion criteria and complemented by snowball searches. Data on facility name, location, confirmed cases, containment measures, communication, protection strategies, and conflicts was extracted for each outbreak and reporting date. Evidence synthesis: meta-analysis and negative binomial regression. Findings We identified 337 media reports on 101 Sars-CoV-2 outbreaks in 99 reception and accommodation centers in Germany. The pooled Sars-CoV-2 attack rate was 13.1% (95% confidence interval, CI: 9.8- 16.7). Outbreak sites implementing mass quarantine (n=76) showed higher rates (15.7; 95% CI: 11.6 - 20.2) compared to sites using conventional strategies (6.6; 95%CI: 3.1 - 11.2), yielding a rate ratio of 0.44 (95%CI: 0.27-0.72) adjusted for testing strategies, type and size of accommodation. Conflicts occurred in at least 11.8% of all outbreaks. Few sites reported specific measures to protect refugees with special needs. Conclusion Mass quarantine is associated with higher attack rates, and appears to be a counter-productive containment measure in overcrowded camps. Although further research with individual-level data is required to rule out residual confounding, reception centers and refugee camps should follow the available guidelines on Covid-19 response and refrain from mass quarantine if physical distancing cannot be guaranteed. +
++Abstract Background: This study aims to estimate the prevalence of COVID-19 in the general population of Iran. Methods: The target population was all Iranian people aged six years and older in the country. A stratified random sampling design was used to select 28,314 subjects from among the individuals registered in the electronic health record systems used in primary health care in Iran. Venous blood was taken from each participant and tested for the IgG antibody against COVID-19. The prevalence of COVID-19 was estimated at provincial and national levels after adjusting for the measurement error of the laboratory test, non-response bias, and sampling design. Results: Of the 28,314 Iranians selected, 11,256 (39.75%) participated in the study. Of these, 5406 (48.0%) were male, and 6851 (60.9%) lived in urban areas. The mean (standard deviation) participant age was 35.89 (18.61) years. The adjusted prevalence of COVID-19 until August 20, 2020 was estimated as 14.2% (95% uncertainty interval: 13.3%, 15.2%), which was equal to 11,958,346 (95% confidence interval: 11,211,011-12,746,776) individuals. The prevalence of infection was 14.6%, 13.8%, 16.6%, 11.7%, and 19.4% among men, women, urban population, rural population, and individuals 60 years of age and older, respectively. Ardabil, Golestan, and Khuzestan provinces had the highest prevalence, and Alborz, Hormozgan, and Kerman provinces had the lowest. Conclusions: Based on the study results, a large proportion of the Iranian population had not yet been infected by COVID-19. The observance of hygienic principles and social restrictions should therefore continue until the majority of the population has been vaccinated. Keywords: COVID-19, Seroprevalence, Survey, Nationwide, Population-based, Iran, IgG test +
++The implementation of lockdowns has been a key policy to curb the spread of COVID-19 and to keep under control the number of infections. However, quantitatively predicting in advance the effects of lockdowns based on their stringency and duration is a complex task, in turn making it difficult for governments to design effective strategies to stop the disease. Leveraging a novel mathematical “hybrid” approach, we propose a new epidemic model that is able to predict the future number of active cases and deaths when lockdowns with different stringency levels or durations are enforced. The key observation is that lockdown-induced modifications of social habits may not be captured by traditional mean-field compartmental models because these models assume uniformity of social interactions among the population, which fails during lockdown. Our model is able to capture the abrupt social habit changes caused by lockdowns. The results are validated on the data of Israel and Germany by predicting past lockdowns and providing predictions in alternative lockdown scenarios (different stringency and duration). The findings show that our model can effectively support the design of lockdown strategies by stringency and duration, and quantitatively forecast the course of the epidemic during lockdown. +
++A growing body of research has highlighted the disproportionately negative impact of the COVID-19 pandemic on women globally. This paper contributes to this work by interrogating the lived realities of 64 women in the UK through semi-structured interviews, undertaken during the first and second periods of lockdown associated with COVID-19 in 2020. Categorising the data by theme and type of gendered disadvantage, this paper explores the normative and policy-imposed constraints experienced by women in 2020, highlighting the role that government can and should proactively play in attending to gender inequalities throughout its COVID-19 response. +
++COVID-19 is an ongoing pandemic caused by the highly infectious coronavirus SARS-CoV-2 that is engaging worldwide scientific research to find a timely and effective eradication strategy. Great efforts have been put into anti-COVID-19 vaccine generation in an effort to protect the world population and block SARS-CoV-2 spread. To validate the protective efficacy of the vaccination campaign and effectively control the pandemy, it is necessary to quantify the neutralizing antibodies induction by vaccination, since they have been established to be a correlate of protection. In this work a SARS-CoV-2 pseudovirus neutralization assay, based on a replication incompetent lentivirus expressing an adapted form of CoV-2 S protein and an ACE2/TMPRSS2 stably expressing cell line, have been minimized in term of protocol steps without loss of accuracy. The goal of the present simplified neutralization system is to improve SARS-CoV-2 vaccination campaign by means of an easy and accessible approach to be performed in any medical laboratory, maintaining the sensitivity and quantitative reliability of classical serum neutralization assays. Further this assay can be easily adapted to different coronaviruses variants by simply modifying the pseudotyping vector. +
+Clinical Study in the Treatment of Patients With COVID-19 - Condition: COVID-19
Interventions: Drug: Molixan; Drug: Placebo
Sponsor: Pharma VAM
Not yet recruiting
Diagnostic Performance of the ID Now™ COVID-19 Screening Test Versus Simplexa™ COVID-19 Direct Assay - Condition: Covid19
Intervention: Diagnostic Test: ID Now™ COVID-19 Screening Test
Sponsor: Groupe Hospitalier Paris Saint Joseph
Active, not recruiting
Dose-Ranging Study to Assess the Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19 - Condition: COVID-19
Interventions: Drug: Melatonin; Drug: Placebo
Sponsors: State University of New York at Buffalo; National Center for Advancing Translational Science (NCATS)
Not yet recruiting
A Study to Evaluate the Efficacy and Safety of Brilacidin in Hospitalized Participants With COVID-19 - Condition: COVID-19
Interventions: Drug: Brilacidin; Drug: Placebo; Drug: Standard of Care (SoC)
Sponsor: Innovation Pharmaceuticals, Inc.
Recruiting
DCI COVID-19 Surveillance Project - Condition: Covid19
Intervention: Diagnostic Test: SARS-CoV-2 RT-PCR Assay for Detection of COVID-19 Infection
Sponsors: Temple University; Dialysis Clinic, Inc.
Recruiting
Safety, Tolerability and Pharmacokinetics of Second Generation VIR-7831 Material in Non-hospitalized Participants With Mild to Moderate COVID-19 - Condition: Covid19
Interventions: Biological: VIR-7831 (Gen1); Biological: VIR-7831 (Gen2)
Sponsors: Vir Biotechnology, Inc.; GlaxoSmithKline
Recruiting
Corticosteroids for COVID-19 - Condition: Covid19
Interventions: Drug: Prednisone; Device: Point of Care testing device for C-reactive protein
Sponsor: University of Alberta
Not yet recruiting
Effects of Telerehabilitation After Discharge in COVID-19 Survivors - Condition: Covid19
Intervention: Other: Telerehabilitation
Sponsor: Hacettepe University
Recruiting
A Study to Assess if a Medicine Called Bamlanivimab is Safe and Effective in Reducing Hospitalization Due to COVID-19 - Condition: Covid19
Interventions: Biological: Bamlanivimab; Other: Standard of Care
Sponsors: Fraser Health; Fraser Health Authrority Department of Evaluation and Research Services; Surrey Memorial Hospital Foundation; University of British Columbia; Centre for Health Evaluation and Outcome Sciences; BC Support Unit; Abcellera; Surrey Memorial Hospital Clinical Research Unit
Not yet recruiting
Efficacy of Adaptogens in Patients With Long COVID-19 - Condition: Covid19
Interventions: Dietary Supplement: ADAPT-232 oral solution; Other: Placebo oral solution
Sponsors: Swedish Herbal Institute AB; National Family Medicine Training Centre, Georgia; Tbilisi State Medical University; Phytomed AB
Not yet recruiting
Effectiveness of the Adsorbed Vaccine COVID-19 (Coronavac) Among Education and Law Enforcement Professionals With Risk Factors for Severity - Condition: Covid19
Intervention: Biological: Adsorbed SARS-CoV-2 (inactivated) vaccine
Sponsors: Fundação de Medicina Tropical Dr. Heitor Vieira Dourado; Butantan Institute
Not yet recruiting
COVID-19 Vaccination of Immunodeficient Persons (COVAXID) - Condition: Covid19
Intervention: Biological: Comirnaty (COVID-19, mRNA vaccine)
Sponsors: Karolinska University Hospital; Karolinska Institutet
Recruiting
Vitamin D3 Levels in COVID-19 Outpatients From Western Mexico - Condition: Covid19
Intervention: Dietary Supplement: Vitamin D3
Sponsor: University of Guadalajara
Completed
Dietary Supplements for COVID-19 - Condition: Covid19
Interventions: Drug: Vitamin D3 50,000 IU; Dietary Supplement: Vitamin C/Zinc; Dietary Supplement: Vitamin K2/D; Other: Microcrystalline Cellulose Capsule; Other: Medium Chain Triglyceride Oil
Sponsors: The Canadian College of Naturopathic Medicine; Ottawa Hospital Research Institute
Not yet recruiting
Efficacy and Safety Evaluation of Inhaleen Inhalation in Hospitalized COVID-19 Patients - Condition: Covid19
Interventions: Device: Carragelose; Device: NaCl
Sponsors: Marinomed Biotech AG; Austian Research Promotion Agency
Recruiting
ARB-Based Combination Therapy for the Clinical Management of Hypertension and Hypertension-Related Comorbidities: A Spotlight on Their Use in COVID-19 Patients - Essential hypertension is the most common cardiovascular (CV) risk factor, being primarily involved in the pathogenesis of CV disease and mortality worldwide. Given the high prevalence and growing incidence of this clinical condition in the general population in both high and low-income countries, antihypertensive drug therapies are frequently prescribed in different hypertension-related CV diseases and comorbidities. Among these conditions, evidence are available demonstrating the clinical…
COVID-19 vaccination and antirheumatic therapy - The COVID-19 vaccination will be the largest vaccination programme in the history of the NHS. Patients on immunosuppressive therapy will be amongst the earliest to be vaccinated. Some evidence indicates immunosuppressive therapy inhibits humoral response to the influenza, pneumococcal and hepatitis B vaccines. The degree to which this will translate to impaired COVID-19 vaccine responses is unclear. Other evidence suggests withholding methotrexate for two weeks post vaccination may improve…
COVID-19 pneumonia: do not leave the corticosteroids behind! - The host inflammatory response is critical in the progression of lung injuries in patients with SARS-CoV-2. Corticosteroids (CS) have been widely used as immunomodulating agents, but the right timing, dosage and type of molecule are unknown. In fact, the early use of CS could facilitate the viral replication but late administration may not prevent the alveolar damage. Nevertheless, a short administration of high doses of CS in the early stage of the inflammatory phase resulted in favorable…
Targeting mesenchymal stem cell therapy for severe pneumonia patients - Pneumonia is the inflammation of the lungs and it is the world’s leading cause of death for children under 5 years of age. The latest coronavirus disease 2019 (COVID-19) virus is a prominent culprit to severe pneumonia. With the pandemic running rampant for the past year, more than 1590000 deaths has occurred worldwide up to December 2020 and are substantially attributable to severe pneumonia and induced cytokine storm. Effective therapeutic approaches in addition to the vaccines and drugs under…
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2 - Drug repurposing is a rapid approach to identify therapeutics for the treatment of emerging infectious diseases such as COVID-19. To address the urgent need for treatment options, we carried out a quantitative high-throughput screen using a SARS-CoV-2 cytopathic assay with a compound collection of 8,810 approved and investigational drugs, mechanism-based bioactive compounds, and natural products. Three hundred and nineteen compounds with anti-SARS-CoV-2 activities were identified and confirmed,…
Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19 - The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat the infection and the absence of a suitable vaccine to prevent it. While some individuals contracting the SARS-CoV-2 infection exhibit a well coordinated immune response and recover, others display a dysfunctional immune response leading to serious complications including ARDS, sepsis, MOF; associated with morbidity and mortality. Studies revealed that in patients with a dysfunctional immune response,…
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface - COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a new recently emerged sarbecovirus. This virus uses the human ACE2 enzyme as receptor for cell entry, recognizing it with the receptor binding domain (RBD) of the S1 subunit of the viral spike protein. We present the use of phage display to select anti-SARS-CoV-2 spike antibodies from the human naïve antibody gene libraries HAL9/10 and subsequent identification of 309 unique fully human antibodies against S1. 17 antibodies are…
Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers - The circulating metabolome provides a snapshot of the physiological state of the organism responding to pathogenic challenges. Here we report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care). This analysis revealed major disease- and stage-associated shifts in the metabolome, meaning…
Contributions of human ACE2 and TMPRSS2 in determining host-pathogen interaction of COVID-19 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is at present an emerging global public health crisis. Angiotensin converting enzyme 2 (ACE2) and trans-membrane protease serine 2 (TMPRSS2) are the two major host factors that contribute to the virulence of SARS-CoV-2 and pathogenesis of coronavirus disease-19 (COVID-19). Transmission of SARS-CoV-2 from animal to human is considered a rare event that necessarily requires strong evolutionary adaptations. Till date no other…
Exploring dynamics and network analysis of spike glycoprotein of SARS-COV-2 - The ongoing pandemic caused by coronavirus SARS-COV-2 continues to rage with devastating consequences on human health and global economy. The spike glycoprotein on the surface of coronavirus mediates its entry into host cells and is the target of all current antibody design efforts to neutralize the virus. The glycan shield of the spike helps the virus to evade the human immune response by providing a thick sugar-coated barrier against any antibody. To study the dynamic motion of glycans in the…
Structural analogues of existing anti-viral drugs inhibit SARS-CoV-2 RNA dependent RNA polymerase: A computational hierarchical investigation - The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic, resulting in an exponentially increased mortality globally and scientists all over the world are struggling to find suitable solutions to combat it. Multiple repurposed drugs have already been in several clinical trials or recently completed. However, none of them shows any promising effect in combating COVID-19. Therefore, developing an effective drug is an unmet…
Drug Repurposing and Polypharmacology to Fight SARS-CoV-2 Through Inhibition of the Main Protease - The outbreak of a new coronavirus (SARS-CoV-2), which is responsible for the COVID-19 disease and is spreading rapidly around the world, urgently requires effective therapeutic treatments. In this context, drug repurposing represents a valuable strategy, as it enables accelerating the identification of drug candidates with already known safety profiles, possibly aiding in the late stages of clinical evaluation. Moreover, therapeutic treatments based on drugs with beneficial multi-target…
The Effect of Supervision Waivers on Practice: A Survey of Massachusetts Nurse Practitioners During the COVID-19 Pandemic - CONCLUSIONS: Temporary removal of state-level practice barriers alone is not sufficient to achieve immediate full scope of practice for NPs. The successful implementation of modernized scope of practice laws may require a collective effort to revise organizational and payer policies accordingly.
Disinfectants Used in Stomatology and SARS-CoV-2 Infection - Effective disinfection is a basic procedure in medical facilities, including those conducting dental surgeries, where treatments for tissue discontinuity are also performed, as it is an important element of infection prevention. Disinfectants used in dentistry and dental and maxillofacial surgery include both inorganic (hydrogen peroxide, sodium chlorite-hypochlorite) and organic compounds (ethanol, isopropanol, peracetic acid, chlorhexidine, eugenol). Various mechanisms of action of…
What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology - Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against…
Sars-CoV-2 vaccine antigens - - link
SARS-COV-2 BINDING PROTEINS - - link
Compositions and methods for detecting SARS-CoV-2 spike protein - - link
+Anordnung zum Versprühen einer Substanz in die menschliche Mundhöhle und/oder in den Rachen, dadurch gekennzeichnet, dass die Anordnung eine Sprühflasche mit einer Substanz aufweist, die wenigstens Aroniasaft und eine Alkoholkomponente aufweist. +
+基于水疱性口炎病毒载体的新型冠状病毒嵌合重组疫苗及其制备方法与应用 - 本发明公开了基于水疱性口炎病毒载体的新型冠状病毒嵌合重组疫苗及其制备方法与应用。该重组疫苗的活性成分为重组病毒rVSV‑SARS‑CoV/2‑RBD,为将水疱性口炎病毒的糖蛋白G替换为嵌合囊膜蛋白S后得到的病毒;所述嵌合囊膜蛋白S为将SARS‑CoV囊膜蛋白S的RBD替换为SARS‑CoV‑2囊膜蛋白S的RBD后得到的蛋白;所述SARS‑CoV囊膜蛋白S的RBD的氨基酸序列为SARS‑CoV囊膜蛋白S氨基酸序列的第315‑536位;所述SARS‑CoV‑2囊膜蛋白S的RBD的氨基酸序列为SARS‑CoV‑2囊膜蛋白S氨基酸序列的第319‑541位。该重组病毒对新冠病毒的疫苗研制具有重要意义。 - link
一种3-羟基丁酰化修饰蛋白质药物及其制备方法和应用 - 本发明涉及医药技术领域,公开了一种3‑羟基丁酰化修饰蛋白质药物(例如抗体)及其制备方法和应用,特别是一种3‑羟基丁酰化修饰抗体及其制备方法和应用。发明人经过大量实验发现,3‑羟基丁酸及其类似物修饰蛋白质药物(例如抗体)后,可以显著提高蛋白质药物的热稳定性、对蛋白酶水解的抗性,降低蛋白质药物的等电点,并显著延长其在受试者体内的半衰期,进而提高其药效。修饰后所得蛋白质药物在科研和临床方面具有广阔的应用前景和较高的商业价值。 - link
新冠病毒重组融合蛋白、其制备方法和应用 - 本发明提供一种新冠病毒重组融合蛋白、其制备方法和应用。本发明通过对新冠病毒S和N重组融合蛋白的基因序列进行设计,选择最优的片段进行整合,再通过人源HEK293细胞系统重组表达融合蛋白,经过纯化后对融合蛋白的分子量、纯度进行检测,最后利用融合蛋白制成新冠病毒抗体胶体金检测试纸条/试剂盒。与单独使用S蛋白或N蛋白制备的胶体金检测试纸条相比,该重组融合蛋白制备的胶体金检测试纸条具有更高的灵敏度和更低的漏检率。此外,本发明提供的新冠病毒重组融合蛋白可广泛应用于不同平台技术的新冠抗体检测试剂盒开发,如胶体金、荧光免疫层析、化学发光和酶联免疫等。 - link
+Atemluft-Desinfektionsvorrichtung mit einem am Körper eines Lebewesens (2) tragbaren Gehäuse (32), aufweisend:
wenigstens einen sich außerhalb der Atemluft-Bestrahlungskammer (33) erstreckenden Kühlkörper (37), der thermisch sowohl an die wenigstens eine UV-LED-Einheit (31, 31.1, 31.2), als auch an die aus dem wärmeleitenden Material bestehende Kammer-Innenwand (36, 39, 40) angekoppelt ist.
制备重组新型冠状病毒Spike蛋白的方法 - 本发明提供了一种制备重组新型冠状病毒Spike蛋白的方法。本发明首先提供以下多肽作为信号肽在制备重组新型冠状病毒Spike蛋白中的应用:SEQ ID No. 10所示氨基酸序列组成的多肽。本发明采用特定信号肽,构建含有编码重组新型冠状病毒Spike蛋白的多核苷酸的表达载体,转染哺乳动物细胞以分泌表达重组新型冠状病毒Spike蛋白,可显著提高Spike蛋白在HEK293细胞中的分泌表达水平。 - link
新型冠状病毒抗体检测试剂盒及其制备方法与应用 - 本发明提供一种新型冠状病毒抗体检测试剂盒及其制备方法与应用。所述试剂盒包括:IgG结合分子,抗IgM抗体,荧光标记的新型冠状病毒S1蛋白,荧光标记的新型冠状病毒N蛋白,S1蛋白的hIgG抗体阳性标准品,N蛋白的hIgG抗体阳性标准品,S1蛋白的hIgM抗体阳性标准品,N蛋白的hIgM抗体阳性标准品,阴性对照hIgG抗体样品,阴性对照hIgM抗体样品;其中,所述IgG结合分子与抗IgM抗体负载于不同粒径的纳米颗粒上。本发明的试剂盒用于新型冠状病毒抗体检测,可在1‑2h内快速完成血清中新型冠状病毒中和性抗体的检测,待检样品用量少,特异性强,灵敏度高,重复性好,操作简单,实验室要求低以及安全性高。 - link
Who Ordered a Smear Campaign Against Andrew Cuomo’s First Accuser? - When Lindsey Boylan first publicly accused New York’s governor of sexual harassment, in December, damaging government documents about her were leaked to the press. - link
L.A.’s Disorganized Vaccination Rollout and the Dream of Universal Health Care - The failures to reach the hardest hit populations are another reminder of how the system neglects so many. - link
Biden Has Few Good Options for the Unaccompanied Children at the Border - The new Administration is coming under fire for a policy it says protects young migrants. - link
Why COVID-19 Vaccines Aren’t Yet Available to Everyone - President Biden has promised that all adults will be eligible to receive a vaccine by May. But manufacturing and distributing enough doses will depend on a lot of things going right. - link
The Cross-Country Skier Jessie Diggins Makes History in a Year of COVID-19 and Climate Change - Diggins, who won a gold medal at the 2018 Winter Olympics, becomes the first American woman to win the World Cup. - link
+Here’s how to keep them straight. +
++There are just four categories at the Grammy Awards where artists from all musical genres compete against one another — Album of the Year, Record of the Year, Song of the Year, and Best New Artist. In these four races, country artists bump up against R&B musicians, and they both take on pop stars. If an artist wins one of these awards, they’ll make headlines and get to give a nice speech during the awards telecast. +
++But the Grammys’ many, many categories are already steeped in confusing industry-speak, and the top four awards are no different. With the exception of Best New Artist, it’s easy to confuse the other three. +
++Here’s everything you need to know to keep these categories straight. +
+ ++The Album of the Year award is the most prestigious Grammy there is, the rough equivalent of the Best Picture Oscar. The category honors an entire LP, from the first track to the last, and everything about the production of the album’s sound. +
++Originally, the Album of the Year award went only to the album’s main artist. Today, the album’s producers, sound engineers, mixers, and songwriters are also honored, as are any featured artists who appear on the album. Generally, if you participated in creating a significant portion of the album (defined as at least 33 percent of its playing time), you get a golden gramophone. +
++How to remember it: The whole album gets an award! Some people confuse Album of the Year with Record of the Year, since albums used to be on physical records, and the two terms are often used interchangeably in common parlance. But singles also used to be on physical records, and you wouldn’t call a single song “Album of the Year.” +
++The 2021 nominees for Album of the Year are: +
++Folklore — Taylor Swift +
++Future Nostalgia — Dua Lipa +
++Women in Music Part III — Haim +
++Everyday Life — Coldplay +
++Chilombo — Jhené Aiko +
++Black Pumas (Deluxe Edition) — Black Pumas +
++Hollywood’s Bleeding — Post Malone +
++Djesse Vol. 3 — Jacob Collier +
++Record of the Year is often confused with Song of the Year, since both awards go to individual songs. But the distinction is actually somewhat simple. The Record of the Year honors, first and foremost, the performing artist. Song of the Year honors the songwriter. +
++Record of the Year is given to the performing artist, the producers, the sound engineers, the master engineer, and the sound mixers. +
++How to remember it: Instead of thinking of “record” as a physical, spinning record, think of it as the product of a recording studio. Everyone who would be in a recording studio working on the Record of the Year–winning song receives a golden gramophone for this award. +
++The 2021 nominees for Record of the Year are: +
++“Colors” — Black Pumas +
++“Black Parade” — Beyoncé +
++“Rockstar” — Da Baby feat. Roddy Rich +
++“Say So” — Doja Cat +
++“Everything I Wanted” — Billie Eilish +
++“Don’t Start Now” — Dua Lipa +
++“Circles” — Post Malone +
++“Savage” — Megan Thee Stallion feat. Beyoncé +
++The Song of the Year Grammy doesn’t actually honor the performer of the winning song. Instead, it goes to the person or people who wrote the song. +
++It’s easy to confuse this award with Record of the Year because there is often overlap in who is accepting the award. For example, if an artist has songwriting credit on their nominated song — a pretty common occurrence — then the artist might accept the award and give the speech. But they are receiving the award for writing and constructing the song’s lyrics and melodies, not for their performance of the song. +
++How to remember it: Try to think of it as Songwriter of the Year, rather than just Song. +
++The 2021 nominees for Song of the Year are: +
++“Black Parade” — Denisia Andrews, Beyoncé, Stephen Bray, Shawn Carter, Brittany Coney, Derek James Dixie, Akil King, Kim “Kaydence” Krysiuk, and Rickie “Caso” Tice (Beyoncé) +
++“The Box” — Samuel Gloade and Rodrick Moore (Roddy Ricch) +
++“Cardigan” — Aaron Dessner and Taylor Swift (Taylor Swift) +
++“Circles” — Louis Bell, Adam Feeney, Kaan Gunesberk, Austin Post, and Billy Walsh (Post Malone) +
++“Don’t Start Now” — Caroline Ailin, Ian Kirkpatrick, Dua Lipa, and Emily Warren (Dua Lipa) +
++“Everything I Wanted” — Billie Eilish O’Connell and Finneas O’Connell (Billie Eilish) +
++“I Can’t Breathe” — Dernst Emile II, H.E.R., and Tiara Thomas (H.E.R.) +
++“If the World Was Ending” — Julia Michaels and JP Saxe (JP Saxe Featuring Julia Michaels) +
++
+Fox News’s absurd reaction to Biden’s primetime coronavirus speech, explained. +
++Fox News reacted to President Joe Biden’s primetime announcement that all American adults would be eligible for a coronavirus vaccine by May 1 and the country’s aim is to return to a semblance of normalcy by July 4 by insisting that former President Donald Trump actually deserves the credit. But that claim can’t withstand scrutiny. +
++While Trump’s Operation Warp Speed program provided incentives for private companies to speed vaccine development and did directly help Moderna develop an effective vaccine, it’s not necessarily the case that vaccines wouldn’t be available today had it not been for Trump. The first FDA-approved coronavirus vaccine was developed by Pfizer last year without any direct help from the federal government. +
++To be clear — Trump deserves some credit for the fact that multiple vaccines were developed so quickly. As my colleague Dylan Scott reported last October, the federal government’s multibillion-dollar investment in helping companies like Moderna and Johnson & Johnson develop vaccines no doubt helped the country get to a point where there is finally some light at the end of the tunnel. Biden has acknowledged this, saying in December that “I think that the [Trump] administration deserves some credit, getting this [vaccine effort] off the ground, Operation Warp Speed.” +
++But vaccines don’t do much good if there’s no plan to get them into arms, and this is where Trump really fell short. As was the case when the US struggled to ramp up coronavirus testing infrastructure in the early days of the pandemic, the Trump administration’s plan for vaccine distribution did little more than pass the buck to under-resourced states. Trump’s failure to plan for the “last mile” resulted in episodes where unused vaccines were thrown out in the weeks before Biden took office. +
++So while it’s going too far to say Trump deserves no credit, the criticisms Biden opened his primetime speech with are totally fair. +
++“A year ago we were hit with a virus that was met with silence and spread unchecked. Denials for days, weeks, then months,” he said, alluding to Trump’s effort to downplay the coronavirus ahead of and during his failed reelection campaign. “That led to more deaths, more infections, more stress, and more loneliness.” +
+++“A year ago we were hit with a virus that was met with silence, and spread unchecked. Denials for days, weeks, then months. That led to more deaths” – Biden begins his big coronavirus speech by taking shots at Trump pic.twitter.com/gljYpCMLv5 +
+— Aaron Rupar (@atrupar) March 12, 2021 +
+Biden moved on, barely alluding to the former president the rest of the way. But he had already provided Fox News something to get mad about. +
++It’s hard to spin a pandemic response that resulted in more than half a million dead Americans as a success, but during a rant about Biden’s speech on Friday morning, Fox & Friends co-host Brian Kilmeade tried. +
++“We don’t need to go over the 500,000 dead; we had that moment,” he said. “Let’s talk about the future moving forward. Every time he has a chance to praise the previous administration, he not only doesn’t praise, he kicks them in the groin.” +
++++Brian Kilmeade: “We don’t need to go over the 500,000 dead, we had that moment. Let’s talk about the future moving forward. Every time he has a chance to praise the previous administration, he not only doesn’t praise, he kicks them in the groin.” pic.twitter.com/n9OupjYfAF +
+— Bobby Lewis (@revrrlewis) March 12, 2021 +
+Kilmeade’s suggestion that Biden took a cheap shot by criticizing Trump’s coronavirus response echoed what host Sean Hannity said on his show shortly after the speech. +
++“Joe Biden — he needs to pick up the phone, I suggest, call Mar-a-Lago, and, yeah, bring unity to the country, as he says he so desperately wants, and thank President Donald Trump,” he said. Later, he added: “No Trump, no vaccine, Joe. Stop taking credit for something, frankly, you had nothing to do with.” +
++++Hannity: Stop taking credit for something frankly you had nothing to do with pic.twitter.com/81ZD00eLJI +
+— Acyn (@Acyn) March 12, 2021 +
+It’s true that when Trump left office, about 1 million vaccines were being administrated each day. But Biden has nearly tripled that rate in less than two months. +
++So Hannity’s comment that Biden “has nothing to do with” the progress of the US vaccination effort is false. Biden has overseen the federal government purchasing hundreds of millions of vaccine doses, making possible the aggressive timeline he outlined on Thursday. And his administration has overseen the development and implementation of vaccine distribution plans that do more than just rely on the states. +
++But Fox News spin is not only impervious to reality; it’s also impervious to shame. A panel discussion on Hannity featuring former Trump chief of staff Reince Priebus and former Trump press secretary Kayleigh McEnany went after Biden for being too prepared — proving that Fox was prepared to attack Biden if he said anything short of “Thank you, Mr. Trump. You deserve all the credit.” +
++++Hannity and two former Trump administration officials are now attacking Biden for being too prepared pic.twitter.com/HmoXMka3tX +
+— Aaron Rupar (@atrupar) March 12, 2021 +
+In the same vein, while Hannity has been hammering Biden on a nightly basis for minor verbal gaffes that he insists are evidence of some sort of cognitive impairment, a chyron on his Thursday show denigrated Biden for merely “surviv[ing]” a “short, scripted speech.” Damned if he does, damned if he doesn’t. +
++Kilmeade and Hannity’s far-fetched spin was nothing compared to comments from Fox News host Mark Levin, who went on a rant so unhinged on Hannity’s show that you had to wonder if he even watched the same speech. +
++“This speech that Joe Biden gave is the most disgusting, propagandistic speech that a demagogue, even a politician, has ever given,” Levin said. “It is pathetic.” +
++++Meanwhile on Earth 2 pic.twitter.com/dnC66xltse +
+— Aaron Rupar (@atrupar) March 12, 2021 +
+Even the fact that Biden says the country is on track to be able to safely have small Fourth of July gatherings was somehow spun as bad by Tucker Carlson and Laura Ingraham, both of whom complained that Biden is acting like a tyrant by telling them what to do. +
++“How dare you tell us who we can spend the Fourth of July with?” Carlson said. +
++++Tucker: How dare you tell us who we can spend the Fourth of July with pic.twitter.com/YaAtPDuYVl +
+— Acyn (@Acyn) March 12, 2021 +
+“And then to pick Independence Day as the day where he says he might allow people to gather is just so un-American,” said Fox News contributor Mollie Hemingway on Ingraham’s show. “Joe Biden doesn’t get to tell me when I can have a barbecue in my backyard.” +
++As ridiculous as all this may seem, it’s serious stuff to most of the approximately 2.5 million people who are tuning in to watch Fox News’s primetime shows, which remain the top-rated shows in cable news, even without Trump in the White House. +
++Then, on Friday morning, Hannity’s false and misleading rant about how Biden should call Trump and thank him was covered as if it were news by one of the network’s “news side” shows, illustrating one of the ways Fox regularly launders its opinion content into the news cycle. +
++Trump inherited the longest streak of job growth from former President Barack Obama when he took office yet still characterized the state of affairs he inherited as “a mess” even in the earliest days of his administration. Fox did little to push back on that spin. So the idea that Biden has some sort of moral obligation to give Trump credit for anything is hypocritical at best. +
++But in its struggle to land blows on a popular president who just signed a very popular $1.9 trillion Covid relief bill, Fox News is normalizing the absurd by, for instance, trying to turn the mundane into huge scandals and linking Biden with culture war grievance issues. +
++And it’s not just the primetime hosts. On Friday afternoon, Chris Wallace equated Biden fairly criticizing Trump’s Covid response to Trump’s treatment of Obama, saying Biden is “being about as gracious to his predecessor as Donald Trump was to his predecessor.” +
++++Chris Wallace claims Biden is “being about as gracious to his predecessor as Donald Trump was to his predecessor” by criticizing Trump’s Covid response. Reminder - Trump’s political rise in ’11 was due to him spreading racist conspiracy theories that Obama wasn’t really American. pic.twitter.com/ox7LabYpaf +
+— Aaron Rupar (@atrupar) March 12, 2021 +
+Donald Trump, you might remember, rose to political prominence in 2011 by spreading racist conspiracy theories that Obama isn’t really American. So Wallace’s comment is about as false as false equivalences can be. +
++It’s tempting to tune it out, especially given Fox News’s diminished relevance following Trump’s departure from the White House. But as Sen. Tim Scott (R-SC) demonstrated on Friday, elite Republicans share the same warped worldview as Hannity. +
++“Thank God for the genius of the Trump administration,” Scott said during a Fox News interview in response to Biden’s speech. +
++++“Thank God for the genius of the Trump administration” – Sen. Tim Scott pic.twitter.com/R4UHKTke7k +
+— Aaron Rupar (@atrupar) March 12, 2021 +
+Scott’s claim is sure to please Trump, who released a tweet-like statement earlier this week saying “I hope everyone remembers when they’re getting the Covid-19 (often referred to as the China Virus) Vaccine, that if I wasn’t President, you wouldn’t be getting that beautiful ‘shot’ for 5 years, at best, and probably wouldn’t be getting it at all. I hope everyone remembers!” +
++But Scott’s praise of Trump rests on false premises. He claimed that, thanks to Trump, there were “300 million doses ready to be put in arms” on the first day of Biden’s presidency. But that’s not true. +
++According to a recent fact check by Kaiser Health News, Trump had contracts in place for enough vaccine to vaccinate 200 million Americans when he left office, but that’s not the same as “doses ready to be put in arms.” Furthermore, beyond vaccinating health care workers and people in assisted-living facilities, Trump’s plan to get them in arms did little more than offer thoughts and prayers to the states. +
++Unsurprisingly, however, the “news side” hosts Scott was speaking with offered no pushback. +
++We push our clocks forward at 2 am Sunday. Here’s why. +
++On Sunday, March 14, at 2 am, daylight saving time begins. We’ll set our clocks forward one hour, and the change will push sunsets later into the evening hours and sunrises later into the morning hours. The cost is that “springing forward” will temporarily disrupt the sleep of millions of Americans. Yet as simple as it seems, there is still a lot of confusion. +
++The first thing to know: Yes, it begins in the spring, just as the increase in daylight hours starts to become noticeable. And it will end on November 7, right before the darkest time of the year. Let’s sort it all out. +
++Daylight saving time in the US started as an energy conservation trick during World War I and became a national standard in the 1960s. +
++The idea is that in the summer months, we shift the number of daylight hours we get into the evening. So if the sun sets at 8 pm instead of 7 pm, we’d presumably spend less time with the lights on in our homes at night, saving electricity. +
++It also means that you’re less likely to sleep through daylight hours in the morning (since those are shifted an hour later, too). Hence “saving” daylight hours for the most productive time of the day. +
++Overall: We agree, the name is kind of confusing. +
++No, it’s definitely called “daylight saving time.” Not plural. Be sure to point out this common mistake to friends and acquaintances. You’ll be really popular. +
++As Joseph Stromberg outlined in an excellent 2015 Vox article, the actual electricity conservation from the time change is unclear or nonexistent: +
++++Despite the fact that daylight saving time was introduced to save fuel, there isn’t strong evidence that the current system actually reduces energy use — or that making it year-round would do so, either. Studies that evaluate the energy impact of DST are mixed. It seems to reduce lighting use (and thus electricity consumption) slightly but may increase heating and AC use, as well as gas consumption. It’s probably fair to say that energy-wise, it’s a wash. +
+
+Arizona has a simple way to deal with daylight saving time: Most of the state ignores it. +
++Fifty years ago, the state legislature opted to keep the clocks in most of the state in standard time all year. One reason: Arizona summers are very hot, and an earlier sunset gives residents more time to enjoy tolerable temperatures before bed, as AZcentral explains. (What’s confusing: The Navajo Nation in Arizona does use DST.) +
++Hawaii also doesn’t observe DST. The island state is the farthest south of all states and rejected it because it doesn’t see a hugely noticeable daylight hour difference between winter and summer months. +
++If you’re a bit confused about which states follow daylight saving time and which do not, I don’t blame you. That’s because lately, a few states have looked into joining Arizona and Hawaii, but with a twist: They want daylight saving time to be in place all year long. +
++In the November 2018 election, Californians voted in favor of a ballot measure that paves the way for this. The measure, which passed with 60 percent of the vote, simply grants the California Legislature the power to vote to change the clocks permanently. Any changes would need to start with a two-thirds majority vote in the state legislature — which hasn’t happened yet. +
++And even then, the time change wouldn’t be a given. The federal government would have to approve it; that has uncertain prospects, too. +
++In 2018, the Florida government approved the delightfully named Sunshine Protection Act, which seeks to permanently leave Florida in daylight saving time. (Essentially, it would mean that Florida will be one hour ahead of the rest of the East Coast during the winter months.) Massachusetts has looked into a similar measure. +
++The bill is still waiting on approval from Congress before it can go into effect. Sen. Marco Rubio (R-FL) has put forth a few bills to push the approval forward, but they haven’t moved at all. The latest version of Rubio’s bill — which has some Democratic co-sponsors — would keep the whole country in daylight saving time permanently. +
++Arkansas, too, passed a bill to make daylight saving time permanent, but it included the condition that the changes wouldn’t go into effect until its bordering states changed their clocks permanently as well. Other states that have approved legislation to enact year-long daylight saving time include Washington, Tennessee, Oregon, Nevada, and Alabama. Some Maryland legislators are interested, too. But none of the changes can go into effect without approval from the federal government. +
++So for now, all these states will be changing their clocks on Sunday along with the rest of us. Sorry! +
++It’s worth thinking about what would happen if Congress abolished daylight saving time (or kept it going all year long). +
++How might our patterns change? Blogger and cartographer Andy Woodruff decided to visualize this with a great series of maps. +
++The goal of these maps is to show how abolishing daylight saving time, extending it all year, or going with the status quo changes the number of days we have “reasonable” sunrise and sunset times. +
++Reasonable, as defined by Woodruff, is the sun rising at 7 am or earlier or setting after 5 pm (so one could, conceivably, spend some time in the sun before or after work). +
++This is what the map looks like under the status quo of twice-yearly clock shifts. A lot of people have unreasonable sunrise times (the dark spots) for much of the year: +
+ ++Here’s how things would change if daylight saving were abolished (that is, if we just stuck to the time set in the winter all year). It’s better, particularly on the sunrise end: +
+ ++And here’s what would happen if daylight saving were always in effect. The sunrise situation would actually be worse for most people. But many more people would enjoy after-work light — and there’s a strong argument to make that this after-work light is actually worth more. (More on that below.) +
+ ++(Note: The length of light we experience each day wouldn’t actually change; that’s determined by the tilt of Earth’s axis. But we would experience it in times more accommodating for our modern world. Be sure to check out the interactive version of these maps on Woodruff’s website.) +
++In 2015, Stromberg made the compelling case that the daylight saving time shift into the evening should be extended year-round. Having more light later could benefit us in a surprising number of ways: +
++A bit. When we shift clocks forward one hour in the spring, many of us will lose that hour of sleep. In the days after daylight saving time starts, our biological clocks are a little bit off. It’s like the whole country has been given one hour of jet lag. +
++One hour of lost sleep sounds like a small change, but we humans are fragile, sensitive animals. Small disruptions in our sleep have been shown to alter basic indicators of our health and dull our mental edge. +
++And when our biological clocks are off, everything about us is out of sync. Our bodies run this tight schedule to try to keep up with our actions. Since we usually eat a meal after waking up, we produce the most insulin in the morning. We’re primed to metabolize breakfast before even taking a bite. It’s more efficient that way. +
++(There’s some good research that finds taking over-the-counter melatonin helps reset our body clocks to a new time. Read more about that here.) +
++Being an hour off schedule means our bodies are not prepared for our actions at any time of the day. +
++One example: driving. +
++In 1999, researchers at Johns Hopkins and Stanford universities wanted to find out what happens on the road when millions of drivers have their sleep disrupted. +
++Analyzing 21 years of fatal car crash data from the US National Highway Transportation Safety Administration, they found a very small, but significant, increase in road deaths on the Monday after the clock shift in the spring: The number of deadly accidents jumped to an average of 83.5 on the “spring forward” Monday compared with an average of 78.2 on a typical Monday. +
++And it seems it’s not just car accidents. Evidence has also mounted of an increase in incidences of workplace injuries and heart attacks in the days after we spring forward. +
++That’s easy! Well, not really: All it would take is an act of Congress. But I wouldn’t count on this happening any time soon. +
++
World singles TT qualification tournament | Indians eye Olympic qualification - There are four spots available for men and five for women.
Ind vs SA preview | Lack of lower-order firepower a worry for India ahead of 4th ODI - In the third ODI, India couldn’t step up the rate with the team managing just 27 runs in the last 30 balls following the dismissal of vice-captain Harmanpreet Kaur
Ind vs Eng preview | Following heavy defeat, India aim for better batting effort in 2nd T20 - The bowling department didn’t have enough runs on board to put up a fight but whether one of the three spinners can make way for a fast bowler remains to be seen.
Vijay Hazare Trophy final: Prithvi Shaw-led Mumbai up against a young, spirited U.P. - Prithvi Shaw has scored four centuries and he could even be expected to go past the 900-run mark.
Seeking re-election as International Hockey Federation president, Narinder Batra files nomination - The FIH Congress was originally scheduled for last year but was postponed due to the COVID-19 pandemic, handing Batra an extended first term
Jammu-Srinagar National Highway cleared of landslide debris - Officials said the road clearance work was completed around 3 p.m. on Saturday but only the local stranded traffic was allowed to ply towards their destinations.
Stage set for MLC poll in East Godavari on Sunday - 11 contestants are in the fray
India’s first AC railway terminal to function soon: Union Minister - “Named after one of the foremost civil engineers, Bharat Ratna Sir M. Visvesvaraya, the nation’s first centralised AC railway terminal in Bengaluru is set to become operational soon,” Piyush Goyal tweeted.
Centre must reaffirm 1991 Act on places of worship: CPI(M) - Polit Bureau voices concern over SC notice on PIL challenging status quo
Cong. leader criticises BJP at rally - “BJP people chant Lord Ram’s name, but behave worse than Ravana”, remarked former Minister and Congress leader Krishna Byre Gowda, at a party rally in
Covid-19 pandemic: Italy to shut shops and schools amid infection spike - Most shops, restaurants and schools will be closed on Monday as Coronavirus infections rise.
UK exports to European Union drop 40% in January - Official figures show a sharp drop in trade in goods with the EU as the Brexit transition period ended.
Corinne Masiero: Actress protests naked at ‘French Oscars’ ceremony - Corinne Masiero sheds a donkey skin and bloodstained dress at a coronavirus-dominated César Awards.
Brussels bombers ‘murdered elderly man as a test’ - Two brothers who killed 31 people in 2016 earlier shot dead a 76-year-old, a Belgian report says.
Brexit: UK delays border checks on EU goods into Great Britain - Ministers say the move will help firms after Covid - but Labour says it “smacks of ill-preparedness”.
The Code Breaker is the CRISPR chronicle you need to read - Q&A: Walter Isaacson’s account is a thrilling tale of scientific discovery. - link
Exchange servers first compromised by Chinese hackers hit with ransomware - As if Exchange users didn’t already have enough to worry about, they have this. - link
“Shocking” genetic data suggest Ebola lurked in survivor for 5-6 years - Ebola virus is known to persist in some survivors—but not for this long. - link
Qualcomm smartphones are the next devices to get hit by chip shortage - Qualcomm faces pandemic shortages, Huawei’s sanctions, and Texas power problems. - link
US lawmakers propose Australia-style bill for media, tech negotiations - Both Democrats and Republicans want to do something. Maybe not the same something. - link
+After attracting the bartender’s attention, the bartender says “Ok, I’ll bite. Why are you invisible?” +
++Barack says “Well, I found a bottle on the beach and…then I rubbed it.” “And then…importantly…A genie came out.” “The genie said I could have…3 wishes.” +
++For my first wish, I said “Let me say this, and this is profoundly important…I want Michelle to marry me…I love her,…and I think America will love her too.” That wish was granted. +
++For my second wish, I said “Like all patriotic Americans, I am deeply patriotic…and I want to be President…of the United States…so I can serve my country.” That wish was granted too. +
++And then, for my third wish, I started by saying “Let me be clear…” +
+ submitted by /u/4x4Xtrm
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+They call it the “Pal Region” +
+ submitted by /u/error521
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+In the classroom the next day, Joe gave his example first, “My dad is a farmer and we have chickens. One day we were taking lots of eggs to market in a basket on the front seat of the truck when we hit a big bump in the road; the basket fell off the seat and all the eggs broke. The moral of the story is not to put all your eggs in one basket.” +
++“Very good,” said the teacher. +
++Next, Mary said, “We are farmers too. We had twenty eggs waiting to hatch, but when they did we only got ten chicks. The moral of this story is not to count your chickens before they’re hatched.” +
++“Very good,” said the teacher again, very pleased with the responses so far. +
++Next it was Dave’s turn to tell his story: “My dad told me this story about my Aunt Karen…. Aunt Karen was a flight engineer in the war and her plane got hit. She had to bail out over enemy territory and all she had was a bottle of whiskey, a machine gun, and a machete.” +
++“Go on,” said the teacher, intrigued. +
++“Aunt Karen drank the whiskey on the way down to prepare herself. Then she landed right in the middle of a hundred enemy soldiers. She killed seventy of them with the machine gun until she ran out of bullets. Then she killed twenty more with the machete ’til the blade broke. And then she killed the last ten with her bare hands.” +
++“Good heavens,” said the horrified teacher, “What did your father say was the moral of that frightening story?” +
++“Stay away from Aunt Karen when she’s been drinking…” +
+ submitted by /u/eli5ask
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+I tell him I used to do a lot of gay porn. +
+ submitted by /u/baalpwns
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+I’m quite upset. We were together for 7 seasons. +
+ submitted by /u/farqueue2
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