diff --git a/archive-covid-19/08 April, 2024.html b/archive-covid-19/08 April, 2024.html new file mode 100644 index 0000000..b647048 --- /dev/null +++ b/archive-covid-19/08 April, 2024.html @@ -0,0 +1,163 @@ + +
+ + + ++Background: SARS-CoV-2 vaccines have been shown to be safe and effective against infection and severe COVID-19 disease worldwide. Certain co-morbid conditions cause immune dysfunction and may reduce immune response to vaccination. In contrast, those with co-morbidities may practice infection prevention strategies. Thus, the real-world clinical impact of co-morbidities on SARS-CoV-2 infection in the recent post-vaccination period is not well established. We performed this study to understand the epidemiology of Omicron breakthrough infection and evaluate associations with number of comorbidities in a vaccinated and boosted population. Methods and Findings: We performed a retrospective clinical cohort study utilizing the Northwestern Medicine Enterprise Data Warehouse. Our study population was identified as fully vaccinated adults with at least one booster. The primary risk factor of interest was the number of co-morbidities. Our primary outcome was incidence and time to first positive SARS-CoV-2 molecular test in the Omicron predominant era. We performed multivariable analyses stratified by calendar time using Cox modeling to determine hazard of SARS-CoV-2. In total, 133,191 patients were analyzed. Having 3+ comorbidities was associated with increased hazard for breakthrough (HR=1.2 CI 1.2-1.6). During the second half of the study, having 2 comorbidities (HR= 1.1 95% CI 1.02-1.2) and having 3+ comorbidities (HR 1.7, 95% CI 1.5-1.9) were associated with increased hazard for Omicron breakthrough. Older age was associated with decreased hazard in the first 6 months of follow-up. Interaction terms for calendar time indicated significant changes in hazard for many factors between the first and second halves of the follow-up period. Conclusions: Omicron breakthrough is common with significantly higher risk for our most vulnerable patients with multiple co-morbidities. Age related behavioral factors play an important role in breakthrough infection with the highest incidence among young adults. Our findings reflect real-world differences in immunity and exposure risk behaviors for populations vulnerable to COVID-19. +
+Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID - Conditions: Long COVID; Brain Fog; Cognitive Change
Interventions: Dietary Supplement: Lactobacillus paracasei PS23; Dietary Supplement: microcrystalline cellulose
Sponsors: Taipei Veterans General Hospital, Taiwan
Not yet recruiting
Fascial Tissue Response To Manual Therapy: Implications In Long Covid Rehabilitation - Conditions: COVID-19
Interventions: Other: Guidebook; Other: Guidebook and Myofascial Reorganization® (RMF).
Sponsors: University of the State of Santa Catarina; Larissa Sinhorim
Recruiting
Evaluation of the Impact of Rehabilitation Strategies and Early Discharge After Respiratory Failure - Conditions: Acute Respiratory Failure
Interventions: Behavioral: Standard of Care; Behavioral: Rehabilitation
Sponsors: Hospital Israelita Albert Einstein
Not yet recruiting
Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) - Conditions: Post-Acute Sequelae of COVID-19
Interventions: Other: Usual care of traditional treatment; Other: Specific DB program/Diaphragmatic manipulation program
Sponsors: University of Minnesota
Recruiting
Short-Chain Fatty Acid (SCFA) as a Connecting Link between Microbiota and Gut-Lung Axis-A Potential Therapeutic Intervention to Improve Lung Health - The microbiome is an integral part of the human gut, and it plays a crucial role in the development of the immune system and homeostasis. Apart from the gut microbiome, the airway microbial community also forms a distinct and crucial part of the human microbiota. Furthermore, several studies indicate the existence of communication between the gut microbiome and their metabolites with the lung airways, called “gut-lung axis”. Perturbations in gut microbiota composition, termed dysbiosis, can have…
SARS-CoV-2 causes dysfunction in human iPSC-derived brain microvascular endothelial cells potentially by modulating the Wnt signaling pathway - CONCLUSION: These findings suggest that SARS-CoV-2 infection causes BBB dysfunction via Wnt signaling. Thus, iPSC-BMELCs are a useful in vitro model for elucidating COVID-19 neuropathology and drug development.
Review: N1-methyl-pseudouridine (m1Ψ): Friend or foe of cancer? - Due to the health emergency created by SARS-CoV-2, the virus that causes the COVID-19 disease, the rapid implementation of a new vaccine technology was necessary. mRNA vaccines, being one of the cutting-edge new technologies, attracted significant interest and offered a lot of hope. The potential of these vaccines in preventing admission to hospitals and serious illness in people with comorbidities has recently been called into question due to the vaccines’ rapidly waning immunity. Mounting…
Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects - CONCLUSIONS: This trial is the first to demonstrate that PCSK9 mAB with evolocumab can modulate circulating immune cell properties and highlights the importance of “stress” profiling of circulating immune cells that more clearly define immune contributions to ASCVD.
Discovery and development of novel 10,12-disubstituted aloperine derivatives against HCoV-OC43 by targeting allosteric site of host TMPRSS2 - By inducing steric activation of the 10CH bond with a 12-acyl group to form a key imine oxime intermediate, 20 novel (10S)-10,12-disubstituted aloperine derivatives were successfully synthesized and assessed for their antiviral efficacy against HCoV-OC43. Of them, compound 3i exhibited the moderate activities against HCoV-OC43, as well as against the SARS-CoV-2 variant EG.5.1 with the comparable EC(50) values of 4.7 and 4.1 μM. A mechanism study revealed that it inhibited the protease activity…
Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease - Flavonoids are naturally occurring metabolites of plants that can inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), which is required for viral replication. Here, we present a protocol to identify flavonoid antagonists of the SARS-CoV-2 Mpro. We describe steps for the expression and purification of Mpro and a kinetic enzymatic assay for Mpro activity using a dequenching fluorescence resonance energy transfer peptide substrate. We then detail…
DLD is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients - Since the discovery of copper induces cell death(cuprotosis) in 2022, it has been one of the biggest research hotspots. cuprotosis related genes (CRGs) has been demonstrated to be a potential therapeutic target for cancer, however, the molecular mechanism of CRGs in coronavirus disease 2019 (COVID-19) infected in DLBCL patients has not been reported yet. Therefore, our research objective is first to elucidate the mechanism and role of CRGs in COVID-19. Secondly, we conducted univariate and…
Immunoglobulin G4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant - CONCLUSION: Heterozygosity for gain-of-function IKZF1 variants underlies autoimmunity/inflammatory diseases, IgG4-RD and B-cell malignancies, the onset of which may occur in adulthood. Clinical and immunological data are similar to those for patients with unexplained IgG4-RD. Patients may therefore benefit from treatments inhibiting pathways displaying IKAROS-mediated overactivity.
Toll like receptor 4 mediates the inhibitory effect of SARS-CoV-2 spike protein on proximal tubule albumin endocytosis - Tubular proteinuria is a common feature in COVID-19 patients, even in the absence of established acute kidney injury. SARS-CoV-2 spike protein (S protein) was shown to inhibit megalin-mediated albumin endocytosis in proximal tubule epithelial cells (PTECs). Angiotensin-converting enzyme type 2 (ACE2) was not directly involved. Since Toll-like receptor 4 (TLR4) mediates S protein effects in various cell types, we hypothesized that TLR4 could be participating in the inhibition of PTECs albumin…
Coordination chemistry suggests that independently observed benefits of metformin and Zn(2+) against COVID-19 are not independent - Independent trials indicate that either oral Zn^(2+) or metformin can separately improve COVID-19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic relationship and therapeutic synergy. Zn^(2+) deficit is a known risk factor for both COVID-19 and non-infectious inflammation. Most dietary Zn^(2+) is not absorbed. Metformin is a naked ligand that presumably increases intestinal Zn^(2+) bioavailability and active absorption by cation transporters known to transport…
SARS-CoV-2 and the Angiotensin-Converting Enzyme 2 Receptor: Angiotensin-Converting Enzyme Inhibitor/Angiotensin 2 Receptor Blocker Utilization and a Shift Towards the Renin-Angiotensin-Aldosterone System Classical Pathway - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic, uses the surface angiotensin-converting enzyme 2 (ACE2) receptor as the site of entry into host cardiac, respiratory, intestinal, renal, and nervous system cells. Predisposing risk factors such as cardiovascular disease increase the risk of developing severe disease. Hypertension is characterized by the stimulation of the renin-angiotensin-aldosterone system…
Ipsilateral and contralateral coadministration of influenza and COVID-19 vaccines produce similar antibody responses - BACKGROUND: World Health Organisation (WHO) and USA Centers for Disease Control and Prevention (U.S. CDC) recommendations now allow simultaneous administration of COVID-19 and other vaccines. We compared antibody responses after coadministration of influenza and bivalent COVID-19 vaccines in the same (ipsilateral) arm vs. different (contralateral) arms.
Inhibition of the RLR signaling pathway by SARS-CoV-2 ORF7b is mediated by MAVS and abrogated by ORF7b-homologous interfering peptide - Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and characterized by dysregulated immune response. Studies have shown that the SARS-CoV-2 accessory protein ORF7b induces host cell apoptosis through the tumor necrosis factor alpha (TNF-α) pathway and blocks the production of interferon beta (IFN-β). The underlying mechanism remains to be investigated. In this study, we found that ORF7b facilitated viral infection and…
TRAIL and IP-10 dynamics in pregnant women post COVID-19 vaccination: associations with neutralizing antibody potency - INTRODUCTION: The aim of this study is to investigate changes in TNF-related apoptosis-inducing ligand (TRAIL) and gamma interferon-induced protein 10 (IP-10) after COVID-19 vaccination in pregnant women and to explore their association with neutralizing antibody (Nab) inhibition.
Assessment of the activity of the immune system in patients with inflammatory bowel diseases and asymptomatic COVID-19 - CONCLUSIONS: The increased concentration of IL-2 may result from its regulatory role in inhibiting excessive activation of the immune system; however, considering the studies of patients with severe COVID-19, its role in the initial phase of SARS-CoV-2 infection requires further research.
Jessica Tisch, the Ex-N.Y.P.D. Official Trying to Tame New York’s Trash - The city has lived in filth for decades. Can Jessica Tisch, a scion of one of the country’s richest families, finally clean up the streets? - link
Maggie Rogers’s Journey from Viral Fame to Religious Studies - The singer-songwriter’s sudden celebrity made her a kind of minister without training. So she went and got some. - link
Battling Under a Canopy of Russian and Ukrainian Drones - The commander of one of Ukraine’s most skilled units sent his men on a dangerous mission that required them to elude a swarm of aerial threats. - link
Park Chan-wook Gets the Picture He Wants - With “The Sympathizer,” the director of “Oldboy” and “The Handmaiden” comes to American television. - link
How Chinese Students Experience America - COVID, guns, anti-Asian violence, and diplomatic relations have complicated the ambitions of the some three hundred thousand college students who come to the U.S. each year. - link
+Eclipses inspire awe, create opportunities for science — and cause angst among energy-grid operators. +
++Today, millions of people will gather to marvel at the total solar eclipse. +
++The awe that eclipses inspire is profound. “You suddenly feel as though you can see the clockwork of the solar system. Where you think you lived doesn’t look like the same place anymore,” Ernie Wright, who creates data visualizations and eclipse maps for NASA, told Vox. +
++“We kind of know — in the back of our minds — that we live in a giant ball and it revolves around a hot ball of gas, and we’re floating in space. But you don’t really believe it until you see something like a total solar eclipse, where everything is all lined up and you go whoaaa.” +
++But that same power that inspires awe can also be seriously disruptive to — and sometimes scary for — life on Earth. +
++For some communities in the path of totality, tens of thousands of out-of-town eclipse-seekers are set to generate upward of $1 billion in revenue across numerous cities, from Austin, Texas, to Rochester, New York. Though lucrative, many places are girding for water shortages, sewage and garbage issues, and horrendous traffic. +
++The eclipse could also disrupt the US energy grid, threatening potential brownouts and blackouts in some areas of the country. +
++Solar eclipses aren’t just spectator events; they’re also an opportunity to study our solar system and our energy systems at home. +
++As my colleague Umair Irfan reports, the United States currently has more than 139 gigawatts of solar electricity generation capacity. That’s more than two and a half times the amount of solar that was on the grid during the last total eclipse in 2017. The upcoming eclipse will also shade a path twice as wide as the last one. Though much of the country will see some decline in solar power production, the biggest fall will be directly under the moon’s shadow. +
++For the most part, power grid operators aren’t too worried about outages or major problems during the eclipse. They saw this coming and planned for it. Unlike disruptions such as clouds, the moon passing between the Earth and the sun is easily predictable up to 1,000 years in advance. +
++Behind the scenes, though, it will require a carefully choreographed series of energy transactions to precisely ramp up electricity from a handful of generators and route it across hundreds of miles of transmission lines to millions of customers to precisely match the needs of every monitor, air conditioner, and light bulb the instant they turn on. +
+ ++What they learn during this totality will prove useful as even more intermittent power sources connect to the grid. Power generators and transmission systems face even more severe stresses from rising energy demand and threats like wildfires, drought, and storms, many worsened by climate change. +
++Texas provides a good example: It has the second-largest solar capacity in the US and the path of the totality cuts straight through it. According to the National Renewable Energy Laboratory, the state is projected to see a nearly 60 gigawatt drop in solar power production when the eclipse passes over. +
++The Texas grid operator, ERCOT, has been running simulations and modeling how the eclipse will affect the state’s power network, which, unlike the rest of the continental US, has few connections to other states. That means it can’t easily buy or sell electricity across state lines if it has too much or (in this case) too little power. +
++But for an ordinary power user — someone like you — it’s unlikely you’ll notice anything about your electricity during the eclipse. Some utilities might have to scramble to secure extra power, but that won’t manifest at the outlet. +
++Phew. +
+ ++Eclipses are a rare moment to observe the solar corona, the sun’s outer atmosphere that can be observed radiating from the eclipsed sun’s outer edges, and the dynamic of solar weather, which can wreak havoc on life on Earth. Radiation from solar storms often ends up hitting the planet, which can lead to beautiful phenomena like the northern lights. But it can also cause massive problems, like energy grid disruptions, major blackouts, or even taking down satellites. +
++Despite how much damage solar storms can do to our tech on Earth, scientists are still struggling to predict them. And that’s because they don’t understand everything about how the corona works. Even though it extends far out from the surface of the sun into freezing cold space, the corona is still a million degrees hotter than the surface of the sun. And scientists aren’t sure why. +
++This is why Shadia Habbal, a professor of solar physics at the University of Hawaii, became an eclipse chaser. +
++“We have some clues [about solar storms],” Habbal told Noam Hassenfeld on a recent episode of Vox’s Unexplainable. “We know what’s causing them, but we can’t predict when they will happen. And that’s one of the things we’re trying to gather: some more information from our eclipse observations.” +
++A total solar eclipse happens somewhere in the world about every 18 months. The next one will be on August 12, 2026, and it will pass over Spain, Iceland, and Greenland. The one after that? August 2, 2027, over North Africa. +
++NASA keeps a catalog of all the eclipses (both solar and lunar) that have occurred or will occur from 1999 BCE to 3000 CE. Check that calendar and you’ll see that the next solar eclipse over the United States will be visible in Alaska in 2033. For the lower 48? 2045. +
++See you then. +
++This story appeared originally in Today, Explained, Vox’s flagship daily newsletter. Sign up here for future editions. +
+From a “Department of Life” to a “future regime” led by Christian men, their ideas could have an outsize influence on Trump’s policies. +
++As president, Trump delivered for anti-abortion voters in the biggest way possible by appointing the three Supreme Court justices who cast the deciding votes to overturn Roe v. Wade. +
++Rather than campaigning on that gift to the anti-abortion movement this year, however, he’s largely running away from it — no doubt because pro-abortion-rights candidates and measures have been consistently winning since Roe fell. +
++In voicing his (potential) support for a 15-week federal ban on the procedure, Trump also said the issue should be left to the states, and that activists pushing for stiffer federal bans should understand that “you have to win elections.” +
++Endorsing a 15-week ban (which would be very unlikely to pass Congress) is Trump’s way of telling moderate and independent voters that “he’s not going to make abortion an issue,” said Mary Ziegler, a law professor at UC Davis and author of the book Abortion and the Law in America: Roe v. Wade to the Present. +
++Indeed, part of Trump’s success in the polls thus far appears to stem from his ability to capture independent voters who are dissatisfied with the economy and angry about immigration, but who may not identify as religious or even as conservative. It’s plausible that Trump might let abortion politics — and issues of reproductive and family policy more generally — fade into the background in a second term. After all, it’s “not something he instinctively cares a lot about,” said Matthew Wilson, a political science professor at Southern Methodist University. +
++However, there are powerful groups within Trump’s coalition — both his base of supporters and his stable of former and current advisers — who do care a lot about abortion. And contraception. And gender identity. And marriage. +
++Trump’s message to these groups, cloaked in religious language, is much different from the one he’s delivering to moderates. And they’re likely to have an outsize influence on policy in a second Trump term, in part because Trump has few social policy positions of his own. +
++Understanding those actors is key to predicting how he and his surrogates might govern in 2025, if they get the chance. +
++The Biden campaign in recent weeks has directed a lot of attention toward Project 2025, a kind of super-team of conservative think tanks and interest groups tasked with creating a playbook for “the next conservative administration.” +
++Led by the Heritage Foundation, the project includes on its advisory board both old-line anti-abortion groups like Susan B. Anthony Pro-Life America (once Susan B. Anthony List) and groups like the Claremont Institute, which rose to prominence during Trump’s presidency. The playbook itself, titled Mandate for Leadership: The Conservative Promise, is more than 800 pages long and includes chapters on how the next conservative president (Trump is not mentioned by name) should overhaul the Departments of Justice and Health and Human Services (HHS). Some of its prescriptions: +
++The Trump campaign has not acknowledged Mandate for Leadership as any kind of playbook. “All 2024 campaign policy announcements will be made by President Trump or members of his campaign team,” campaign officials said in a November statement. “Policy recommendations from external allies are just that — recommendations.” +
++“Project 2025 does not speak for President Trump or his campaign,” a spokesperson for the project told Vox in an email. +
++Nonetheless, many of the authors of Mandate are members of the first Trump administration who would likely have roles in a second. +
++Roger Severino, the author of the HHS chapter, was the director of the HHS Office for Civil Rights under Trump, a role in which he oversaw the removal of nondiscrimination protections for LGBTQ Americans in health care settings. Gene Hamilton, the author of the Justice Department chapter, served in Trump’s DOJ and Department of Homeland Security and worked on the “zero tolerance” immigration policy that separated children from their parents at the border. +
++“These are all people that, in theory, Trump listens to,” Ziegler said. +
++When it came to abortion policy in Trump’s first term, “he delegated,” Ziegler added. Odds are he would do so again, and Project 2025 gives some clues about how and to whom. +
++Trump’s first presidential campaign “did not have a blueprint” for governing because “they did not believe they could win,” said Mini Timmaraju, president of Reproductive Freedom for All (formerly NARAL Pro-Choice America). Trump was still able to stack the court system to wipe out the federal right to an abortion and “completely gut and in some ways remake federal agencies.” +
++“That was with no prep,” Timmaraju said. “I take these guys incredibly seriously.” +
++While some in the Republican coalition work on plans to ban abortion pills, others are continuing the battle against what they’ve branded as liberal “woke” culture, including protections for LGBTQ Americans and efforts toward diversity, equity, and inclusion (DEI). +
++This group includes a newer, more unpredictable part of the conservative ecosystem: the podcasters and influencers who could turn out votes for Trump in 2024, from Joe Rogan to the Nelk Boys. These voices speak directly to young men who might not go to church or think that much about abortion policy, but who can maybe be persuaded that Democrats are waging a war on men and that Donald Trump can stop them. +
++This constituency is dear to Trump’s heart — he and Donald Trump Jr. have both appeared on the Nelk Boys’ podcast, and he has anointed Nick Adams, an over-the-top Australian influencer who calls himself “the Godfather of the ‘Alpha King’ movement,” by writing the foreword for his book. +
++There’s also plenty of overlap, ideologically, between think tanks and anti-woke influencers. Anti-trans rhetoric and policy recommendations crop up throughout Mandate for Leadership, whose foreword proclaims that “children suffer the toxic normalization of transgenderism with drag queens and pornography invading their school libraries.” The document also calls for deleting the terms diversity, equity, and inclusion from every federal rule as part of a drive to “make the institutions of American civil society hard targets for woke culture warriors.” +
++Meanwhile, conservative activists see an opening around “woke” culture issues, especially since other right-wing social positions, like opposition to abortion, are politically unpopular. They’re looking at polls showing that majorities of Americans support restrictions on gender-affirming medical treatments for minors and trans women participating in women’s sports, Wilson said (though a majority also support prohibitions on discrimination against trans people). +
++While Trump doesn’t actually care much about religion, he does love stoking culture wars, so his personal interests are perhaps more aligned with the anti-woke crusaders than with old-line evangelical abortion opponents. All this suggests that trans rights and DEI could remain fixations for him and his party in a second term. +
++A third group that’s influential for Trump on social issues is the Christian nationalist movement, whose adherents believe “the U.S. is a Christian nation and that the country’s laws should therefore be rooted in Christian values,” according to NPR. More than half of Republicans supported these views in a 2023 PRRI/Brookings survey, and the ideology counts among its adherents Rep. Marjorie Taylor Greene (R-GA), who has said, “I am a Christian and I say it proudly: We should be Christian nationalists.” +
++The idea that American laws should be rooted in Christianity isn’t new on the right, but some observers are concerned about the extent to which Christian nationalists today prioritize their worldview over democracy. The Society for American Civic Renewal (SACR), for example, a group open only to straight Christian men who hold supportive views of Trump, has discussed an “aligned future regime” stocked with loyalists, Josh Kovensky writes for Talking Points Memo. +
++SACR’s founder, Charles Haywood, has speculated openly about his role in a potential civil war, writing that he might serve as a “warlord” in “conditions where central authority has broken down,” such as “more-or-less open warfare with the federal government, or some subset or remnant of it.” +
++Abortion comes up frequently as a touchstone for Christian nationalist groups, said Kristin Kobes Du Mez, a professor of history and gender studies at Calvin University who studies religion and politics. “I have seen that issue surface in explicitly Christian nationalist spaces as a reason to jettison democracy,” Du Mez told Vox. +
++Christian nationalists were heavily involved in the January 6 Capitol riot, experts say, with four of six protest permits issued that day going to groups with links to the movement. Adherents remain some of Trump’s most committed supporters, said Laura Field, a political theorist and scholar in residence at American University. “Some of them talk about him as a new Cyrus” — a Persian king referenced in the Old Testament who did not worship the Jewish God but nonetheless carried out God’s plans, Field said. +
++Trump speaks directly to such supporters in prayer-style closings of recent campaign speeches, promising, “we are one movement, one people, one family and one glorious nation under God.” He has also leaned into the legacy of January 6, calling the date of the insurrection a “beautiful day” and playing a song at rallies sung by incarcerated participants, whom he calls “J6 hostages.” +
++While it’s unclear how much of the vision (or visions) held by Christian nationalists could realistically come to pass in a second Trump administration, it is clear that these groups now represent, to a great degree, Trump’s base, one he’s been courting zealously on what he hopes is his second journey to the White House. +
++There’s a lot of overlap between the think-tank world, anti-woke influencers, and Christian nationalists. Ryan P. Williams, president of the Claremont Institute, is also a board member of SACR. And the male supremacist ethos of the anti-woke podcasters fits right in with the tenets of Christian nationalists, who often see men as the rightful heads of both household and state. +
++But perhaps the biggest area of overlap lies in approach. Post-Dobbs, anti-abortion forces have undergone a reinvention, becoming “a movement less focused on winning over the public and more focused on exercising power through the executive and the courts,” Ziegler said. +
++That determination to push through unpopular policies through consolidation of power runs through Mandate for Leadership and through the ideas of Christian nationalist groups as well. +
++It’s a reminder that while Trump does need to pay attention to public opinion during his campaign — hence his (sometimes) careful language around issues like abortion — a big part of his appeal as a candidate and the leader of a movement is his perceived ability to flout public opinion and do whatever he and his most loyal supporters want. +
++
++
+Don’t worry if you missed the 2024 eclipse. There will be more. +
++Total solar eclipses like the one crossing America today are beautiful, but they’re fleeting. Totality, when the sun is completely covered by the moon, lasts just a few minutes. And the whole thing — from the start of the partial eclipse to the end — takes just a few hours. The experience is sublime, but it’ll leave you wanting more. +
++Here’s the good news: Total solar eclipses happen somewhere in the world about every 18 months. That’s how long it takes for the specific conditions that create eclipses (the phases of the moon, the distance of the moon to Earth, and the moon crossing the plane of Earth’s orbit) to line back up. +
++The next total solar eclipse will be on August 12, 2026, and it will pass over Spain, Iceland, and Greenland. The one after that? August 2, 2027, over North Africa. +
++NASA keeps a catalog of all the eclipses (both solar and lunar) that have occurred or will occur from 1999 BCE to 3000 CE. +
++That’s why we know, for instance, that on January 27, 2837, a total solar eclipse will pass over southern Mexico. (Will any humans be around to see it?) +
++The next solar eclipse over the United States will be visible in Alaska in 2033. And the next one in the lower 48 states will be in 2045. +
+ ++
“Just M.S. Dhoni things…”: former Chennai Super Kings captain smashes massive sixes ahead of Kolkata Knight Riders clash - Chennai Super Kings are positioned number 4 in the points table; while Kolkata Knight Riders are at second position.
IPL-17 | Inconsistent Punjab Kings face unpredictable Sunrisers Hyderabad in mid-table clash - Both SRH and PBKS have two wins and two losses from their four matches to be tied with two other teams in the middle with four points and they will be desperate to break out of the mid-table logjam first.
IPL 2024 | Pace sensation Mayank Yadav suffers stride strain, didn’t bowl after one over - Mayank Yadav came to bowl in the fourth over of Titans’ chase of 164, but he could clock in excess of 140 kmph only twice in the over before walking off the field with the LSG physio
IPL-17 | Lizaad Williams joins Delhi Capitals - Since making his international debut in 2021, the 30-year-old Williams has represented South Africa in two Tests, four ODIs and 11 T20 Internationals. He has joined Delhi Capitals at his base price of ₹50 lakh.
Morning Digest | Number of women candidates contesting Lok Sabha elections grew 16-fold from 1957 to 2019; Onion traders cry foul over underpriced exports to UAE, and more - Here is a select list of stories to start the day
Bengaluru police arrest man who posed as doctor and cheated cab drivers - Based on a complaint, a police team, led by Inspector Raju G.P., tracked down the accused and arrested him from his house at Tambaram in Chennai. The police recovered 21 fake notes of ₹500 denomination and nine mobile phones worth ₹90,000 from him.
Air India and BIAL sign agreement to make Bengaluru premier aviation hub of south India - Air India said that this partnership will stimulate the MRO ecosystem and is projected to generate over 1,200 new job opportunities for highly skilled individuals in the State.
Tamil Nadu businessman jumps off 19th floor of hotel in Bengaluru - He had checked in at the hotel in High Grounds on April 6
Fakir Dingaleshwara swami accuses BJP of discriminating between communities in Karnataka, says his fight in Dharwad against Union Minister Pralhad Joshi is for self-respect - He pointed out that the BJP has given tickets to three persons from the small community of Brahmins while other communities have been denied their share
Lok Sabha elections | PM Modi to conduct roadshow in Chennai on April 9; strict traffic arrangements in place - It may be recalled that the Chennai city police had already banned flying of drones and unmanned aerial vehicles within its jurisdiction from March 1 till April 29
Germany faces genocide case over Israel weapon sales - Nicaragua accused Berlin of “facilitating” genocide by selling over $300m worth of weapons to Israel.
Ukraine nuclear plant drone strike prompts warning - The International Atomic Energy Agency warns Russia and Ukraine not to attack nuclear facilities.
Bucha’s wounds still raw two years on - A town known for its brutal Russian occupation is being cleaned up and rebuilt, but for many the emotional scars remain.
Russia-friendly populist elected Slovak president - Peter Pellegrini accused his rival of being a warmonger who would send Slovak soldiers to fight in Ukraine.
‘Worst floods in decades’ hit Kazakhstan and Russia - Tens of thousands are evacuated in northern Kazakhstan, amid warnings that floods are spreading in Russia.
A frozen lake and several Lamborghinis provide lessons on traction control - Electronic traction control is more important than ever as electric motors proliferate. - link
Why are there so many species of beetles? - Diet played a key role in the evolution of the vast beetle family tree. - link
Claims of TikTok whistleblower may not add up - He only worked there 6 months and many of his allegations are improbable at best. - link
NASA knows what knocked Voyager 1 offline, but it will take a while to fix - “Engineers are optimistic they can find a way for the FDS to operate normally.” - link
$158,000 ALS drug pulled from market after failing in large clinical trial - The drug is now unavailable to new patients; its maker to lay off 70% of employees. - link
A farmer was in a bar drinking and looking all depressed. His friend asked him why he was looking depressed and he replied, "Some things you just can’t explain. -
++This morning I was outside milking a cow. As soon as the bucket was full the cow kicked it down with his left foot so I tied up his left foot to a pole. I began to fill up the bucket again and he kicked it down with his right foot, so I tied his right foot to a pole too. As soon as I finished milking the cow again he knocked down the bucket with his tail and I took off my belt and tied up his tail with my belt. As I was tying up his tail, my pants dropped down, then my wife came out and well, trust me, some things you just can’t explain." +
+ submitted by /u/YZXFILE
[link] [comments]
(NSFW) A sumo wrestler is getting married to a very small woman. -
++A massive sumo wrestler, about 6’7, and over 450lbs, is getting married. His wife is very, very small, about 4’5 and maybe 90 lbs or so. +
++After they say their vows, a few of his friends come up to him, and one says- “This is gonna sound rude, but how the hell do you guys have sex?” +
++The sumo responds, “Well, I lift her up, place her on my dick, and move her up and down with both hands” +
++Oh“, says the guy,”that’s not too bad" +
++Sumo replies- “Yeah, its a lot like jacking off, except now I have someone to talk to.” +
+ submitted by /u/eskimopoodle
[link] [comments]
Barack Obama walks into a bar, but he is invisible. -
+
+After attracting the bartender’s attention, the bartender says “Ok, I’ll bite. Why are you invisible?”
Barack says “Well, I found a bottle on the beach and…then I rubbed it.” “And then…importantly…A genie came out.” “The genie said I could have…3 wishes.”
For my first wish, I said “Let me say this, and this is profoundly important…I want Michelle to marry me…I love her,…and I think America will love her too.” That wish was granted.
For my second wish, I said “Like all patriotic Americans, I am deeply patriotic…and I want to be President…of the United States…so I can serve my country.” That wish was granted too.
And then, for my third wish, I started by saying “Let me be clear…”
+
submitted by /u/kylie_doll
[link] [comments]
A man finds a lamp with a genie inside -
++A man finds a lamp with a genie inside. The genie tells the man that he can grant him one wish. Since the man is already quite wealthy and relatively happy, he asks for the only thing bothering him at the moment - he asks to reach orgasm at the same time as his wife. +
++After a few weeks, the man returns to the lamp, rubs it and the genie comes out. +
++“Hey Genie, I’m afraid I’ll have to cancel my last wish.” +
++“What’s wrong? Did I make a mistake while granting the wish?” curiously asks the genie. +
++“Well no, nothing’s wrong, but imagine this: You’re in the pub with your friends. You’re playing cards, drinking beer… and suddenly - Orgasm.” +
+ submitted by /u/Botosup
[link] [comments]
A man and his pig walk into a bar… -
++(apologies if this has been posted before) +
++The pig has three good legs, and one wooden leg. +
++“Now there’s a story,” says the barman. “I’ll give you a free beer if you tell me about the pig.” +
++“Pig’ll ’ave a beer too,” says the farmer. +
++The barman agrees, and after downing half the tankard, the farmer says, "Now, this ’ere pig, ’es a good pig. Faithful, loyal, better at ’erding sheep than a dog, says me. Now I’ll tell you, we were out in the ute, and a tyre blew. Skidded off the track, and the truck rolled. +
++“Now, I were stuck upside down and injured, like, but pig could get out. ’e crawled out of the window, trotted three mile over hill and through creek to get me wife, so ’e did. And when the ambulance arrived, pig trotted all three mile back to get them to me. Is a good pig, so ’e is. Saved me life, I reckon.” +
++The barman is suitably impressed, but says “That’s a hell of a story mate, but that doesn’t explain the wooden leg.” +
++“Oh that!” exclaims the farmer. “Oh, well, like I said, pig saved my life. An’ a pig like that, well, you don’t eat ’im all at once do yer!” +
+ submitted by /u/Eldon42
[link] [comments]