++The SARS-CoV-2 antibody neutralization response and its evasion by emerging viral variants are unknown. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples from 233 RT-PCR-confirmed COVID-19 individuals with detailed demographics and followed up to seven months. A broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization were associated with COVID-19 severity. A subgroup of high responders maintained high neutralizing responses over time, representing ideal convalescent plasma therapy donors. Antibodies generated against SARS-CoV-2 during the first COVID-19 wave had reduced immunoreactivity and neutralization potency to emerging Spike variants. Accurate monitoring of SARS-CoV-2 antibody responses would be essential for selection of optimal plasma donors and vaccine monitoring and design. +
++Background South Korea was one of the epicenters for both the 2015 Middle East Respiratory Syndrome and 2019 COVID-19 outbreaks. However, there has been a lack of published literature, especially using the Electronic Medical Records (EMR), that provides a comparative summary of the prognostic factors present in the coronavirus-derived diseases. Therefore, in this study, we aimed to evaluate the distinct clinical traits between the infected patients of different coronaviruses to observe the extent of resemblance within the clinical features and to identify unique factors by disease severity that may influence the prognosis of COVID-19 patients. Methods We utilized the common data model (CDM), which is the database that houses the standardized EMR. We set COVID-19 as a reference group in comparative analyses. For statistical methods, we used Levene9s test, one-way ANOVA test, Scheffe post hoc test, and Games-howell post hoc test, and Student9s t-test for continuous variables, and chi-squared test and Fisher9s exact test for categorical variables. With the variables that reflected similarity in more than two comparisons between the disease groups yet significantly different between the COVID-19 severity groups, we performed univariate logistic regression to identify which common manifestations in coronaviruses are risk factors for severe COVID-19 outcomes. Findings We collected the records of 2840 COVID-19 patients, 67 MERS patients (several suspected cases included), 43 SARS suspected patients, and 87 HCoV patients. We found that a significantly higher number of COVID-19 patients had been diagnosed with comorbidities compared to the MERS and HCoV groups (48.5% vs. 10.4 %, p < 0.001 and 48.5% vs. 35.6%, p < 0.05) and also that the non-mild COVID-19 patients reported more comorbidities than the mild group (55.7% vs. 47.8%, p < 0.05). There were overall increases in the levels of fibrinogen in both sets of disease and severity groups. The univariate logistic regression showed that the male sex (OR: 1.66; CI: 1.29-2.13, p < 0.001), blood type A (OR: 1.80; CI: 1.40-2.31, p < 0.001), renal disease (OR: 3.27; CI: 2.34-4.55, p < 0.001), decreased creatinine level (OR: 2.05; CI: 1.45-2.88, p < 0.001), and elevated fibrinogen level (OR: 1.59, CI: 1.21-2.09, p < 0.001) are associated with the severe COVID-19 prognosis, whereas the patients reporting gastrointestinal symptoms (OR: 0.42; CI: 0.23-0.72, p < 0.01) and increased alkaline phosphatase (OR: 0.73; CI: 0.56-0.94, p < 0.05) are more less likely to experience complications and other severe outcomes from the SARS-CoV-2 infection. Interpretation The present study observed the highest resemblance between the COVID-19 and SARS groups as clinical manifestations that were present in SARS group were linked to the severity of COVID-19. In particular, male individuals with blood type A and previous diagnosis of kidney failure were shown to be more susceptible to developing the poorer outcomes during COVID-19 infection, with a presentation of an elevated level of fibrinogen. +
++We report test results for SARS-CoV-2 antibodies in an occupational group of postgraduate research students and current members of staff at Kings College London. Between June and July 2020, antibody testing kits were sent to n=2296 participants; n=2004 (86.3%) responded, of whom n=1882 (93.9%) returned valid test results. Of those that returned valid results, n=124 (6.6%) tested positive for SARS-CoV-2 antibodies, with initial comparisons showing variation by age group and clinical exposure. +
++BACKGROUND As of January 1, 2021, there have been 81,947,503 confirmed cases of COVID-19, resulting in 1,808,041 deaths worldwide. Several vaccines are now available for emergency use, but it will take many months to immunize the world population. There is a pressing need for outpatient treatment now. We reviewed the possible options. METHODS We reviewed up-to-date information from several sources to identify potential treatments to be utilized now for COVID-19. We searched for all ongoing, completed and published trial results with subject numbers of 100 or more, and used a targeted search to find announcements of unpublished trial results. RESULTS As of December 27, 2020, we identified 750 trials currently in recruitment phase. Of these, 122 were directed at prevention in healthy individuals, 100 were classified as treatment of outpatients with documented infection, and 390 were for treatment of hospitalized inpatients. There were 9 trials focusing on the post discharge Tail phase. Among the trials, there were 60 vaccine trials, 120 trials of hydroxychloroquine, 33 trials of alternative therapy, 12 trials of colchicine, 38 trials of anticoagulants, 22 trials of the RNA polymerase inhibitor favipiravir (FVP), 19 trials of interferons, 18 trials of glucocorticoid, and 58 trials of plasma based products. Closure of enrollment was projected by the end of the year for 153 trials. We found 83 publications reporting findings in human studies on 14 classes of agents, and on 7 vaccines. There were 45 randomized or active controlled studies, the rest retrospective observational analyses. Most publications dealt with hospitalized patients, only 18 publications in outpatients. Remdesivir, convalescent plasma, and synthetic anti-spike protein antibodies have been granted emergency use authorization in the United States. There is also support for glucocorticoid treatment of the COVID-19 respiratory distress syndrome. There is data supporting the use of several antiviral medications, some of which are in use in other countries. CONCLUSION. Vaccines and antibodies are highly antigen specific. There is a need for antiviral agents in addition to mass immunization. It will be necessary for public health authorities to make hard decisions, with limited data, to prevent the continued spread of the disease and deaths. +
++Background: A rapid influx of patients to intensive care and infection control measures during the COVID-19 pandemic required the rapid development of innovative redeployment and training strategies. Methods: We conducted a systematic search of 9 databases including key terms related to intensive care AND training AND redeployment AND healthcare workers. Analysis consisted of a narrative synthesis of quantitative study outputs, and a framework-based thematic analysis of qualitative study outputs and grey literature. These results were then combined applying an interpretative synthesis. Results: Twenty papers were analysed. These took place primarily in the UK (N=8, 40%) and USA (N=5, 25%). Themes included in the results are Redeployment: Implementation strategies and learnings; Redeployed staff experience and strategies to address their needs; Redeployed staff learning needs; Training formats offered and training evaluations; and Future redeployment and training concerns. Some of the redeployment implementation and training strategies documented in this review are: Skills-based redeployment, buddy support systems, and agreeing on locally-specific principles, rather than strict procedures. Conclusion: The COVID-19 pandemic presented unique challenges to deliver training promptly while following infection control recommendations and develop flexible redeployment strategies. This study synthesises original approaches to tackle these challenges which are relevant to inform the development of targeted and adaptative training and redeployment plans. +
++Background: The majority of U.S. reports of COVID-19 clinical characteristics, disease course, and treatments are from single health systems or focused on one domain. Here we report the creation of the National COVID Cohort Collaborative (N3C), a centralized, harmonized, high-granularity electronic health record repository that is the largest, most representative U.S. cohort of COVID-19 cases and controls to date. This multi-center dataset supports robust evidence-based development of predictive and diagnostic tools and informs critical care and policy. Methods and Findings: In a retrospective cohort study of 1,926,526 patients from 34 medical centers nationwide, we stratified patients using a World Health Organization COVID-19 severity scale and demographics; we then evaluated differences between groups over time using multivariable logistic regression. We established vital signs and laboratory values among COVID-19 patients with different severities, providing the foundation for predictive analytics. The cohort included 174,568 adults with severe acute respiratory syndrome associated with SARS-CoV-2 (PCR >99% or antigen <1%) as well as 1,133,848 adult patients that served as lab-negative controls. Among 32,472 hospitalized patients, mortality was 11.6% overall and decreased from 16.4% in March/April 2020 to 8.6% in September/October 2020 (p = 0.002 monthly trend). In a multivariable logistic regression model, age, male sex, liver disease, dementia, African-American and Asian race, and obesity were independently associated with higher clinical severity. To demonstrate the utility of the N3C cohort for analytics, we used machine learning (ML) to predict clinical severity and risk factors over time. Using 64 inputs available on the first hospital day, we predicted a severe clinical course (death, discharge to hospice, invasive ventilation, or extracorporeal membrane oxygenation) using random forest and XGBoost models (AUROC 0.86 and 0.87 respectively) that were stable over time. The most powerful predictors in these models are patient age and widely available vital sign and laboratory values. The established expected trajectories for many vital signs and laboratory values among patients with different clinical severities validates observations from smaller studies, and provides comprehensive insight into COVID-19 characterization in U.S. patients. Conclusions: This is the first description of an ongoing longitudinal observational study of patients seen in diverse clinical settings and geographical regions and is the largest COVID-19 cohort in the United States. Such data are the foundation for ML models that can be the basis for generalizable clinical decision support tools. The N3C Data Enclave is unique in providing transparent, reproducible, easily shared, versioned, and fully auditable data and analytic provenance for national-scale patient-level EHR data. The N3C is built for intensive ML analyses by academic, industry, and citizen scientists internationally. Many observational correlations can inform trial designs and care guidelines for this new disease. +
++The decline of active COVID-19 cases in many countries in the world has proved that lockdown policies are indeed a very effective measure to stop the exponential spread of the virus. Still, the danger of a second wave of infections is omnipresent and it is clear, that every policy of the lockdown has to be carefully evaluated and possibly replaced by a different, less restrictive policy, before it can be lifted. Tracing of contacts and consequential tracing and breaking of infection-chains is a promising and comparably straightforward strategy to help containing the disease, although its precise impact on the epidemic is unknown. In order to quantify the benefits of tracing and similar policies we developed an agent-based model that not only validly depicts the spread of the disease, but allows for exploratory analysis of containment policies. We will describe our model and perform case studies in which we use the model to quantify impact of contact tracing in different characteristics and draw valuable conclusions about contact tracing policies in general. +
++The spread of Coronavirus disease 19 (COVID-19) has led to many healthcare systems being overwhelmed by the rapid emergence of new cases within a short period of time. We explore the ramifications of hospital load due to COVID-19 morbidity on COVID-19 in-hospital patient mortality. We address this question with a nationwide study based on the records of all 22,636 COVID-19 patients hospitalized in Israel from mid-July 2020 to mid-January 2021. We show that even under moderately heavy patient load (>500 countrywide hospitalized severely-ill patients; the Israeli Ministry of Health defined 800 severely-ill patients as the maximum capacity allowing adequate treatment), in-hospital mortality rate of patients with COVID-19 significantly increased compared to periods of lower patient load (250-500 severely-ill patients): 14-day mortality rates were 22.1% (Standard Error 3.1%) higher (mid-September to mid-October) and 27.2% (Standard Error 3.3%) higher (mid-December to mid-January). We further show this higher mortality rate cannot be attributed to changes in the patient population during periods of heavier load. +
+Dexamethasone for COVID-19 - Condition: Â Covid19
Intervention: Â Drug:Â Dexamethasone
Sponsor:  University of Oklahoma
Not yet recruiting
Fluvoxamine Administration in Moderate SARS-CoV-2 (COVID-19) Infected Patients - Condition: Â Covid19
Interventions: Â Drug:Â Placebo; Â Drug:Â Fluvoxamine
Sponsor:  SigmaDrugs Research Ltd.
Recruiting
The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial) - Condition: Â Covid19
Interventions:  Drug: Ivermectin 0.6mg/kg/day;  Drug: Ivermectin 1.0mg/kg/day;  Drug: Placebo;  Drug: Hydroxychloroquine
Sponsor:  Corpometria Institute
Not yet recruiting
APTâą T3X on the COVID-19 Contamination Rate - Condition: Â COVID-19
Interventions:  Drug: Tetracycline hydrochloride 3%;  Drug: Placebo
Sponsors:  University of Nove de Julho;  Santa Casa de Misericórdia de Porto Alegre
Not yet recruiting
A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia - Condition: Â COVID-19
Interventions:  Drug: ORTD-1 low dose;  Drug: ORTD-1 mid dose;  Drug: ORTD-1 high dose;  Other: Vehicle control
Sponsor:  Oryn Therapeutics, LLC
Recruiting
Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air - Condition: Â Covid19
Intervention: Â Diagnostic Test: Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process
Sponsor:  Hospices Civils de Lyon
Not yet recruiting
COVID-19 Immunologic Antiviral Therapy With Omalizumab - Condition: Â Covid19
Interventions: Â Biological:Â Omalizumab; Â Other:Â Placebo
Sponsor: Â McGill University Health Centre/Research Institute of the McGill University Health Centre
Not yet recruiting
IMUNORÂź Preparation in the Prevention of COVID-19 - Condition: Â Covid19
Intervention: Â Drug:Â IMUNOR
Sponsor:  University Hospital Ostrava
Not yet recruiting
Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19 - Condition: Â Covid19
Interventions:  Drug: Vitamin C 500 MG Oral Tablet;  Drug: Tenofovir disoproxyl fumarate 300 MG Oral Tablet;  Drug: Tenofovir disoproxyl fumarate 300 MG plus emtricitabine 200 MG Oral Tablet
Sponsors:  Universidade Federal do Ceara;  Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico;  SĂŁo JosĂ©Â Hospital for Infectious Diseases - HSJ;  Central Laboratory of Public Health of CearĂĄ - Lacen-CE
Recruiting
Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19 - Condition: Â COVID-19
Interventions:  Drug: Doxycycline Tablets;  Drug: Rivaroxaban 15Mg Tab;  Combination Product: Hydroxychloroquine and Azithromycin
Sponsor:  Yaounde Central Hospital
Recruiting
A Phase â
Ąb Clinical Trial of Recombinant Corona Virus Disease-19 (COVID-19) Vaccine (Sf9 Cells) - Condition: Â COVID-19
Interventions: Â Biological: Recombinant COVID-19 vaccine (Sf9 cells); Â Biological:Â Placebo
Sponsors:  Jiangsu Province Centers for Disease Control and Prevention;  West China Hospital
Not yet recruiting
Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Participants â„ 60 Years of Age and Hospitalized With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure - Condition: Â Covid19
Interventions: Â Drug:Â BGE-175; Â Other:Â Placebo
Sponsor:  BioAge Labs, Inc.
Not yet recruiting
Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients - Condition: Â Covid19
Interventions:  Drug: Betadine© bucal 100 mg/ml;  Drug: OximenŸ 3%;  Drug: Clorhexidine Dental PHB©;  Drug: Vitis Xtra Forte©;  Drug: Distilled Water
Sponsors:  FundaciĂłn para el Fomento de la InvestigaciĂłn Sanitaria y BiomĂ©dica de la Comunitat Valenciana;  Hospital Universitario FundaciĂłn JimĂ©nez DĂaz;  Hospital Universitario General de Villalba;  Hospital Universitario Infanta Elena;  Hospital Universitario Virgen de la Arrixaca;  Hospital ClĂnico Universitario de Valencia;  Dentaid SL
Completed
Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia - Condition: Â COVID-19Â Pneumonia
Intervention:  Drug: Cefditoren pivoxil 400mg
Sponsor:  Meiji Pharma Spain S.A.
Recruiting
Early Use of Hyperimmune Plasma in COVID-19 - Condition: Â Covid19
Intervention:  Other: hyperimmune plasma
Sponsors:  Catherine Klersy;  Policlinico San Matteo Pavia Fondazione IRCCS
Recruiting
Decoding the temporal nature of brain GR activity in the NFÎșB signal transition leading to depressive-like behavior - The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-Îș-B (NFÎșB) is a key inflammatory player that is antagonized via anti-inflammatory actions exerted by the glucocorticoid receptor (GR). However, technical limitations have restricted our understanding of how GR is involved in the dynamics of NFÎșB in vivo. In this study, we used an improved lentiviral-based reporter to elucidate the time course of NFÎșB and...
Feasibility of using alternative swabs and storage solutions for paired SARS-CoV-2 detection and microbiome analysis in the hospital environment - CONCLUSIONS: Compared to using a clinical-grade synthetic swab, detection of SARS-CoV-2 from environmental samples collected from ICU rooms of patients with COVID was similar using consumer-grade swabs, stored in 95% ethanol. The yield was best from the swab head rather than the eluent and the low level of RNase activity and lack of antibiotics in these samples makes it possible to perform concomitant microbiome analyses. Video abstract.
Antibody persistence in the first six months following SARS-CoV-2 infection among hospital workers: a prospective longitudinal study - CONCLUSION: Neutralizing antibodies persisted at six months in almost all participants, indicating more durability than initially feared. Anti-RBD antibodies persisted better and even increased over time, possibly related to the preferential detection of progressively higher-affinity antibodies.
Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and targeted treatment of autoimmune and inflammatory diseases - The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in health, but is released upon necrotic cell death as a bioactive mediator. IL-1α is also expressed by infiltrating myeloid cells within injured tissues. The cytokine binds the IL-1 receptor 1 (IL-1R1), as does IL-1ÎČ, and induces the same pro-inflammatory effects. Being a bioactive precursor released upon tissue damage and...
Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice - SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein aggregates in lung fluid, increased lung alveolar wall thickness, and upregulation of serum cytokine levels. A serum protein called serum amyloid P (SAP) has a calming effect on the innate immune system and shows efficacy as a therapeutic for fibrosis...
Host cell glutamine metabolism as a potential antiviral target - A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in...
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19 - The key link between renin-angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin converting enzyme-2), which acts as a double-edged sword, because ACE2 increases the tissue anti-inflammatory response but it is also the entry receptor for the virus. There is an important controversy on several drugs that regulate RAS activity and possibly ACE2, and are widely used, particularly by patients most vulnerable to severe COVID-19. In the lung of healthy rats, we observed that candesartan (an...
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19 - SARS-CoV-2 infection has spread uncontrollably worldwide while it remains unknown how vulnerable populations, such as Down syndrome (DS) individuals are affected by the COVID-19 pandemic. Individuals with DS have more risk of infections with respiratory complications and present signs of auto-inflammation. They also present with multiple comorbidities that are associated with poorer COVID-19 prognosis in the general population. All this might place DS individuals at higher risk of SARS-CoV-2...
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein - The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the ~30 kb viral RNA genome to aid its packaging into the 80-90 nm membrane-enveloped virion. The N protein is composed of N-terminal RNA-binding and C-terminal dimerization domains that are flanked by three intrinsically disordered regions. Here we demonstrate that the N protein's central disordered domain drives phase separation with RNA, and that phosphorylation of an adjacent serine/arginine rich region modulates the physical...
Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A molecular framework of how the virus manipulates host cellular machinery to facilitate infection remains unclear. Here, we focus on SARS-CoV-2 NSP1, which is proposed to be a virulence factor that inhibits protein synthesis by directly binding the human ribosome. We demonstrate biochemically that NSP1 inhibits translation of...
Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro - Quinacrine (Qx), a molecule used as an antimalarial, has shown anticancer, antiprion, and antiviral activity. The most relevant antiviral activities of Qx are related to its ability to raise pH in acidic organelles, diminishing viral enzymatic activity for viral cell entry, and its ability to bind to viral DNA and RNA. Moreover, Qx has been used as an immunomodulator in cutaneous lupus erythematosus and various rheumatological diseases, by inhibiting phospholipase A2 modulating the Th1/Th2...
Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry - Cholesterol 25-hydroxylase (CH25 H) is a key enzyme regulating cholesterol metabolism and also acts as a broad antiviral host restriction factor. Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that can cause vomiting, diarrhea, dehydration and even death in newborn piglets. In this study, we found that PDCoV infection significantly upregulated the expression of CH25H in IPI-FX cells, a cell line of porcine ileum epithelium. Overexpression of CH25H inhibited...
Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: implication of herb-drug interactions in COVID-19 pharmacotherapy - Corona Virus Disease 2019 (COVID-19) has spread all over the world and brings significantly negative effects on human health. To fight against COVID-19 in a more efficient way, drug-drug or drug-herb combinations are frequently used in clinical settings. The concomitant use of multiple medications may trigger clinically relevant drug/herb-drug interactions. This study aims to assay the inhibitory potentials of Qingfei Paidu decoction (QPD, a Chinese medicine compound formula recommended for...
Targeting SARS-CoV-2 Viral Proteases as a Therapeutic Strategy to Treat COVID-19 - The 21^(st) century has witnessed three outbreaks of coronavirus (CoVs) infections caused by severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome (MERS)-CoV and SARS-CoV-2. Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, spreads rapidly and since the discovery of the first COVID-19 infection in December 2019, has caused 1.2 million deaths worldwide and 226,777 deaths in the United States alone. The high amino acid similarity between SARS-CoV-1 and SARS-CoV-2...
COVID-19, Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Inhibition: Implications for Practice - CONCLUSIONS: Further randomized trials are needed to answer definitely the question of whether RAS inhibitors are harmful or beneficial to patients with COVID-19.
COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS - - link
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
Covid 19 - Chewing Gum - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
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Die Erfindung betrifft ein FahrzeuglĂŒftungssystem (1) zum BelĂŒften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link
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Mund-Nasen-Bedeckung (1), wobei die Mund-Nasen-Bedeckung (1) mindestens an einem Ohr eines TrÀgers magnetisch befestigbar ist.
Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link
Trump May Be Gone, But Trumpism Isnât - Even to the disgraceful end of his Presidency, Trump managed to persuade other conservative opportunists that his brand of right-wing populism represents the future of the G.O.P. - link
Can the COVID-19 Vaccine Beat the Proliferation of New Virus Mutations? - Stopping transmission blocks the opportunity for viral mutation. Vaccination is the only means we have of standing in the virusâs way. - link
The Awe and Anguish of Being an American Today - For all the rousing joy of the political transition, our democracy remains deeply imperilled. - link
The Takedown of a Dark-Web Marketplace - One of the worldâs largest illicit bazaars was shuttered using data seized from a fortified bunker in Germany. - link
Andrew Yangâs Ideas on Universal Basic Income Earned Him Fans. But Can He Win Votes? - His pitch in the mayoral race is for New York to become the âanti-povertyâ city. - link
++Navalny was recently arrested upon his arrival in Russia from Germany. +
++Massive protests took place across Russia on Saturday in support of Alexei Navalny, a Russian opposition leader and vocal critic of President Vladimir Putin. Navalny was arrested last Sunday after returning to Moscow from Germany, where he was treated for a poisoning allegedly linked to the Kremlin five months earlier. +
++According to Reuters, about 40,000 people took part in the Moscow demonstrations, although police called that number incorrect, estimating the crowd at 4,000. Several thousands more participated in cities across the country, from Yakutsk in the northeast to St. Petersburg in the west, and about 3,000 demonstrators have been arrested in all. +
++++People are now spreading around the city center, being pushed off Pushkinskaya, the main site of the rally. pic.twitter.com/I3dgZ4f4wV +
+â Ivan Nechepurenko (@INechepurenko) January 23, 2021 +
+Protesters were met by a strong police presence â and government officials had urged citizens to stay home, arguing that the rallies did not have proper authorization. +
++âRespected citizens, the current event is illegal,â police reportedly announced during the demonstration in Moscow. âWe are doing everything to ensure your safety.â +
++Few protesters heeded these warnings, and the number of those arrested in protests in Moscow, St. Petersburg, and about 70 other towns and cities swelled to at least 3,000, according to reports from the human rights monitoring group OVD-Info. That includes about 1,100 people in Moscow alone, as of 11:30 pm Moscow time on Saturday. +
++Navalnyâs wife, Yulia Navalnaya, was among those arrested at this weekendâs protests. Heads of his partyâs regional offices have also been detained in advance of the protests, as well as members of Navalnyâs team, including his press secretary, Kira Yarmysh. +
++Navalnyâs arrest â and the detentions of his team â have galvanized a tremendous mass movement. The size of the Moscow protests is reminiscent of the summer of 2019, when at least 60,000 people demonstrated in that city to demand fair elections. (Navalny was arrested in advance of that movement, too.) +
++While many of the protesters were Navalnyâs supporters, others said they came out more because they want to see a sweeping end to Putinâs authoritarian rule. +
++âI was never a big supporter of Navalny, and yet I understand perfectly well that this is a very serious situation,â Vitaliy Blazhevich â who, at 57, was one of the demonstrationâs more senior participants â told the New York Times. +
++âUnless we keep coming out [to protest], the problem in this country will never go away,â Natalya Krainova, a former teacher, told the Guardian. âAnd that problem is Putin.â +
++Regardless of their motivation, in many places, protesters were met with swift and aggressive police force. +
++Video out of Moscow, for example, shows police dressed in riot gear beating protesters with batons. Dozens of protesters in that city were arrested outside of the Matrosskaya Tishina detention center, where Navalny is being held. +
++++At least 1,090 have been arrested at protests around Russia against @navalny's jailing pic.twitter.com/sRp2BtOl3v +
+â Alec Luhn (@ASLuhn) January 23, 2021 +
+As night fell, police unleashed smoke grenades on downtown Moscow, and protesters responded with snowballs, according to reporter Alec Luhn. +
++++"Fascists!" Snowballs vs batons in Moscow pic.twitter.com/RNp4AOg3eM +
+â Alec Luhn (@ASLuhn) January 23, 2021 +
+The demonstrations were also striking for their enormous geographic diversity. On Twitter, the Atlantic reporter Anne Applebaum collected scenes of large protests â composed largely of young people, many waving Russian flags â in the cities of Irkutsk, Novosirbirsk, Vladivostok, Tomsk, and Yakutsk. +
++++Irkutsk has come out for Navalny. One of many such scenes across Russia today https://t.co/3OHzHJnDqf +
+â Anne Applebaum (@anneapplebaum) January 23, 2021 +
+Yakutsk is in the east of Siberia, while Vladivostok abuts the Sea of Japan. In a Siberian winter, these protesters were also braving brutally cold temperatures, with temperatures approaching -60°F in some places. +
++++As clashes continues in Moscow, more ludicrous footage of the small pro-Navalny protest in Yakutsk earlier, where it was -48 pic.twitter.com/Ne4TvYl51g +
+â Shaun Walker (@shaunwalker7) January 23, 2021 +
+That the protests were so widespread, and that they involved Russians of all ages, is indicative of Navalnyâs appeal and ability to mobilize supporters â especially young people â according to the Washington Post. +
++In recent years, Putin has moved to crack down more aggressively on dissent, with new laws making it more difficult to organize protests. Russians who demonstrated Saturday face jail as well as other consequences. +
++Artyom, a college student who protested, told the Guardian he and his classmates had been threatened with serious academic consequences, which he said many believed meant expulsion, if they participated. +
++Putin seems likely to remain in power, despite the public opposition seen Saturday. A recent change to the Russian constitution would allow Putin to hold power for an additional 15 years. +
++In August, Navalny fell ill at a Siberian airport before boarding a flight to Moscow. His team, concerned he wasnât receiving proper care in Russia, partnered with a humanitarian group that transported him to Germany for treatment. There, doctors traced the cause of his illness, which was found to be novichok, a deadly nerve agent that the Russian government has been known to use. +
++As Voxâs Alex Ward has written, Navalny always pledged he would return to Russia, even as he continued his criticism of Putin from Germany â including directly accusing the Kremlin of trying to kill him in YouTube videos viewed over 40 million times. +
++When Navalny arrived at the Berlin airport on January 17 for his return trip home, he said that he was not afraid, even though Russian officials had threatened to arrest him upon his return. Hundreds of supporters violated anti-protest laws to greet his plane at Moscowâs Vnukovo airport. Instead, the plane was diverted to the Sheremetyevo airport, whereupon Navalny was arrested at passport control. +
++The official charge he faces is failure to appear at a parole hearing, tied to a 2014 embezzlement case. Navalny has claimed those charges are politically motivated. Nevertheless, if the charges stick, he could face years in prison. +
++His newest arrest follows years of attempts by the Kremlin to stifle his opposition, and to dissuade Navalny from coming home, including by placing him on its federal wanted list, and claiming he avoided inspectors while abroad, as Ward has written: +
++++This kind of thing isnât new for Navalny. As mentioned, heâs been arrested before â and even poisoned before â so itâs possible heâll eventually be released and go back to leading Russiaâs anti-Putin movement. Sometimes the Kremlin just wants to remind Navalny whoâs in charge, and slow down his work, in a manner that attempts to maintain the illusion of Russian democracy. +
++But itâs also possible Putin has had it, especially as he seeks to stay in power for life. Removing his top political nemesis would surely make such a ploy easier, though it may invite condemnation from other nations, including the United States newly led by President-elect Joe Biden. +
+
+Navalny has received support from US officials. Hours after Navalnyâs detainment, incoming National Security Adviser Jake Sullivan tweeted a statement condemning the Putin criticâs detainment. âMr. Navalny should be immediately released, and the perpetrators of the outrageous attack on his life must be held accountable,â he wrote. +
++And Rebecca Ross, a spokesperson for the US Embassy in Moscow, tweeted on Saturday that âThe U.S. supports the right of all people to peaceful protest, freedom of expression. Steps being taken by Russian authorities are suppressing those rights.â +
++++We're watching reports of protests in 38 Russian cities, arrests of 350+ peaceful protesters and journalists. The U.S. supports the right of all people to peaceful protest, freedom of expression. Steps being taken by Russian authorities are suppressing those rights. +
+â Rebecca Ross (@USEmbRuPress) January 23, 2021 +
+It is unclear how effective a US response will be, however. Relations between Washington and Moscow â already cool â have deteriorated further since a hack of American federal agencies was linked to Russia in late 2020. Moreover, operations have shuttered at the last two remaining US consulates â one in Vladivostok and one in Yekaterinburg â leaving the US embassy in Moscow as the only US outpost in the entire country. +
+
++The report of more interference efforts comes as the Senate makes plans for its impeachment trial. +
++In the final weeks of his presidency, former President Donald Trump attempted to overturn state election results in Georgia by pressuring officials to âfindâ votes for him. And according to a new report from the New York Times, Trumpâs efforts extended beyond that: He also contemplated replacing the acting US attorney general with one more sympathetic to his efforts to force a change in the Georgia results. +
++The Timesâs Katie Benner reports that Trump and Jeffrey Clark, a Department of Justice lawyer in charge of the civil division, devised a plan that would have seen the Department of Justice working to improperly keep Trump in office by replacing acting attorney general Jeffrey Rosen â who had refused to go along with Trumpâs attempts to undermine election results â with Clark. +
++A rash of DOJ officials, briefed on the plan via conference call on January 3, threatened to resign if that occurred, according to the Times report. That threat, along with a contentious meeting with Rosen, Clark, and Trump in which each DOJ official made their case to the president, reportedly dissuaded Trump from replacing Rosen in the end. +
++But had Trump gone ahead, the Justice Department would have likely become embroiled in his effort to overturn the election, giving such attempts a legitimacy and legal backing they lacked after the failure of dozens of lawsuits that falsely alleged election irregularities. +
++One former Justice Department official called the effort to replace Rosen âan attempted coup at the Justice Dept. â fomented by the President of the United Statesâ on Twitter Friday. +
++For his part, Clark has denied that any plan to fire Rosen existed, and told the Times that he had merely provided counsel to the president. +
++âMy practice is to rely on sworn testimony to assess disputed factual claims,â he said. âThere was a candid discussion of options and pros and cons with the president. It is unfortunate that those who were part of a privileged legal conversation would comment in public about such internal deliberations, while also distorting any discussions.â +
++Changing the leadership of the DOJ would have been among the last attempts by Trump to overturn the election. Beyond his unsuccessful court challenges in battleground states, Trump had also previously tried to harness the power of the DOJ by asking Rosen to investigate Dominion Voting Systems, a company that makes voting equipment and software, and that has been the subject of false claims of vote tampering. The former president also requested the Justice Department to support his campaignâs state-level lawsuits, and was denied. +
++Trump further asked Rosen to appoint special counsels to carry out investigations into disproved claims of voter fraud, which Rosen declined to do. Rosen affirmed his predecessor former Attorney General William Barrâs findings that claims of widespread voter fraud were not supported by evidence. +
++And in one of the most shocking and brazen efforts, Trump called Georgia Secretary of State Brad Raffensperger to ask him to âfindâ enough votes to overturn President Joe Bidenâs narrow margin of victory in the state, even after it was affirmed through two recounts. That call reportedly took place on the same day that Trump had the newly-uncovered conversations with DOJ officials. +
++These efforts ultimately culminated in a rally in Washington, DC, on January 6, during which Trump repeated his false claims about irregularities with the election â and during which he whipped up a crowd that later stormed the US Capitol, leading to his second impeachment. +
++Trump was impeached on January 13 in the House for alleged âincitement of insurrection.â The article of impeachment also argues that Trump âbetrayed his trust as Presidentâ in attempting to coerce officials to back his efforts to overturn the election, as he reportedly did with Rosen. If he is found guilty of these crimes in the Senate, Trump could be barred from holding public office again. +
++On Friday, Senate leaders finally hammered out a deal to begin that trial on February 9. This came after debate over the start time â with Democrats worried that beginning the trial immediately would delay the confirmations of many of Bidenâs administration and Cabinet appointees, and Republicans wanting Trump to have an extended period of time to ready his defense. +
++The House will deliver the article to the Senate on Monday, and senators will be sworn in as jurors Tuesday, but oral arguments wonât begin on February 9, and leaders have signaled that they hope to reach a verdict by the end of that week. +
++By delaying the start for two weeks, Bidenâs administration will be able to prioritize Covid-19 relief and confirming Cabinet posts, Senate Majority Leader Chuck Schumer said Friday. And a spokesperson for Senate Minority Leader Mitch McConnell said the delay gave Trump adequate due process. +
++Trump has begun assembling his defense team. His longtime attorney Rudy Giuliani, who led Trumpâs failed attempts to overturn election results in the courts, will not be on it; last week, he said he could not act as attorney because he was a witness to the January 6 rally. +
++Instead, South Carolina attorney Karl âButchâ Bowers Jr., will head up Trumpâs legal team. Bowers works for a small firm in Columbia, South Carolina, and has been described as a more measured figure than the bombastic Giuliani. Bowers previously successfully defended former South Carolina Gov. Mark Sanford in his own 2009 impeachment hearing, after Sanfordâs extramarital affair came to light. +
+
++The veteran interviewer had been hospitalized with Covid-19 in late 2020. +
++The broadcast journalist Larry King, known for his in-depth interviews and signature style, has died at age 87. His production company, Ora Media, announced Kingâs death in a statement posted to Twitter Saturday morning. +
++King died at Cedars-Sinai Medical Center in Los Angeles, according to the Twitter statement. A cause of death was not given. King had been admitted to the hospital with Covid-19 symptoms in December 2020. +
++ +â Larry King (@kingsthings) January 23, 2021 ++
+King hosted Larry King Live on CNN for 25 years. More recently, he hosted Larry King Now and Politicking with Larry King on Hulu and RT America. These were produced by Ora TV, which he co-founded with the Mexican billionaire investor Carlos Slim. +
++âFor 63 years and across the platforms of radio, television and digital media, Larryâs many thousands of interviews, awards, and global acclaim stand as a testament to his unique and lasting talent as a broadcaster,â reads the statement. âLarry always viewed his interview subjects as the true stars of his programs, and himself as merely an unbiased conduit between the guest and audience.â +
++King became iconic for his preferred interview style: long exchanges in which he asked straightforward questions in a raspy, Brooklyn accent. According to a CNN remembrance broadcast Saturday morning, King interviewed more than 50,000 people across 60 years, including US presidents, world leaders, celebrities, athletes, and more esoteric people like psychics, conspiracy theorists, and those convicted of crimes. +
++And he was perhaps equally known for his bold sartorial choices â he was rarely seen without his signature suspenders, often paired with a bright shirt and colorful necktie. +
++King was born Lawrence Harvey Zeiger to Jewish immigrant parents in 1933 in Brooklyn, New York; he began his career in radio. After changing his name, King worked first in local markets in the Miami area, before joining a national radio broadcast with the now-defunct Mutual Broadcasting System in 1978. The Larry King Show aired there until 1994. +
++In 1985, he joined CNN and launched Larry King Live, a show that made him a household name and regularly had a viewership of over a million people per night. +
++Guests on that show frequently made news. Oprah Winfrey called on then-Sen. Barack Obama to run for president on Kingâs program in 2006. And in 1992, the billionaire Ross Perot said in an interview with King that he would run for president if his supporters could land him on the ballot in all 50 states. Perot went on to run upstart populist campaigns in both 1992 and 1996. +
++The final broadcast of Larry King Live took place on December 10, 2010. King launched Ora TV in 2012. +
++Over the years, he was married eight times to seven women, and had five children. Two of his children died in August of 2020. King was unmarried at the time of his death. +
++He also had health issues, including quintuple heart bypass surgery following a heart attack in 1987. More recently, he underwent surgery to remove a cancerous lung tumor in 2017, and had a stroke in 2019 that left him occasionally using a wheelchair. +
++Nevertheless, he pledged never to retire. +
++On Twitter, fellow broadcasters and other supporters paid tribute to King as news of his death spread. +
++++Just heard the awful news about Larry King. He taught me so much. He was a true mensch. He probably even taught me that word.
+â Craig Ferguson (@CraigyFerg) January 23, 2021 +
So long pal, thanks for all the laughs. Say hi to Rickles. #RIPLarryKing +
+++Such a great headline about #LarryKing in NYT - it shows he had so much breadth..unlike some who can only interview one type of guest (eg politicians), Larry could interview ANYONE and he did and he interviewed EVERYBODY pic.twitter.com/bCCQO5fP6w +
+â Greta Van Susteren (@greta) January 23, 2021 +
+++Larry King was a Brooklyn boy who become a newsman who interviewed the newsmakers. He conducted over 50,000 interviews that informed Americans in a clear and plain way.
+â Andrew Cuomo (@NYGovCuomo) January 23, 2021 +
New York sends condolences to his family and many friends. +
+
+Root the rock as England frustrate Sri Lanka in second Test - England still trail by 42 runs and will seek to wipe out the deficit with Jack Leach and Stuart Broad at the crease on the fourth morning, although Sri Lanka spinner Lasith Embuldeniya has been excellent with career best figures of 7-132.
Pakistan name 6 uncapped players in squad for first Test against South Africa - The uncapped players include off-spinner Sajid Khan and left-arm spinner Nauman Ali, opener Imran Butt, and pacers Haris Rauf and Tabish Khan
Did not expect to debut for India in Australia; was under pressure in first match: Natarajan - The 29-year-old left-arm pacer became the only India player to make a debut in all the three formats in the same tour
Rajasthan Royals appoint Kumar Sangakkara as director of cricket - Sangakkara will be responsible for overseeing the entire cricketing ecosystem of the franchise including coaching structure, auction plans and team strategy, talent discovery and development, as well as the development of the Royals Academy in Nagpur
It would be a blessing if I ever open batting in Tests, says Washington Sundar - One of the heroes of Indiaâs epic triumph in Brisbane, Washington Sundar spoke about the head coachâs influence on him.
Actor rape case: court seeks six more months to complete trial - Only 82 of 300 witnesses examined so far
Farmersâ protest | Proposed Republic Day tractor rally will begin amid tight security after celebrations conclude: Delhi Police - Farmers will not be allowed to enter central Delhi and their presence will be restricted to areas near the city border.
Tharoor to woo young, on-the-fence voters - The MP will also play a role in finalising partyâs election manifesto
JNUSU president calls for united struggle till farm laws are repealed - âThe legislations are intended to benefit corporate groupsâ
PM Modi exhorts youths to defeat ânetwork of lies and rumoursâ on COVID-19 vaccination with right information - Narendra Modi again stressed on âVocal for Localâ, saying it will gain more strength from the âEk Bharat Shreshtha Bharatâ sentiment.
Alexei Navalny: 'More than 3,000 detained' in protests across Russia - Tens of thousands of people join some of the largest rallies against President Vladimir Putin in years.
In pictures: Tens of thousands gather for pro-Navalny protests - Tens of thousands braved a police crackdown to show support for jailed opposition leader Alexei Navalny.
Covid: Italian PM brands vaccine delay 'unacceptable' - Prime Minister Giuseppe Conte has warned he will take legal action against Pfizer and AstraZeneca.
Tse Chi Lop: Alleged Asian drug lord arrested in Amsterdam - Australia believes Tse Chi Lop's syndicate controls up to 70% of narcotics entering the country.
Vissarion: Is this Russian cult leader a fraud? - A mysterious Russian cult leader is accused of embezzling followers' funds and abusing them.
Review: Lupin updates classic French gentleman thief for the 21st century - Omar Sy heads stellar cast in clever series inspired by the works of Maurice Leblanc - link
Is this a fossilized lair of the dreaded bobbit worm? - The giant worms hunted in pretty much the most nightmarish way possible. - link
DDoSers are abusing Microsoft RDP to make attacks more powerful - DDoS amplification attacks have abused all kinds of legit services. Now, it's Windows. - link
Whatâs the technology behind a five-minute charge battery? - The company behind a new battery isn't saying much, but we figured a few things out. - link
The art and science of boarding an airplane in a pandemic - Researchers and airlines obsessed over efficiency now worry about safety, too. - link
+You get a LGBTQ. +
+ submitted by /u/party_in_my_head
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+Nothing, they fast +
+ submitted by /u/TheAverageSJW
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+At first heâs in shock, he wasnât supposed to end up here! But then he starts to look around & notice things. Everyone is always so grouchy because of the heat, so he fixes the AC. And theyâre always bored because thereâs nothing to do, so he fixes the cable box. Slowly but surely he starts to make improvements, until God finally realizes whatâs going on. So God goes to Satan and says, Hey I think you have our guy. We gotta fix this mistake. Satan says, I donât think so, we like him here. Heâs fixing things & making them better. God starts to get frustrated and says, Hey, if you donât give us our guy back, Iâm gonna have to sue you. Satan laughs and says, Where do you think youâre gonna find a lawyer? +
+ submitted by /u/siren_of_amphitrite
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+Hindus, on the other hand, never had any beef. +
+ submitted by /u/porichoygupto
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+"Well it was about the same size as the box the dvd came in." +
+ submitted by /u/dazsmith88
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