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+ + + ++Early warning indicators based on critical slowing down have been suggested as a model-independent and low-cost tool to anticipate the (re)emergence of infectious diseases. We studied whether such indicators could reliably have anticipated the second COVID-19 wave in European countries. Contrary to theoretical predictions, we found that characteristic early warning indicators generally decreased rather than increased prior to the second wave. A model explains this unexpected finding as a result of transient dynamics and the multiple time scales of relaxation during a non-stationary epidemic. Particularly, if an epidemic that seems initially contained after a first wave does not fully settle to its new quasi-equilibrium prior to changing circumstances or conditions that force a second wave, then indicators will show a decreasing rather than an increasing trend as a result of the persistent transient trajectory of the first wave. Our simulations show that this lack of time scale separation was to be expected during the second European epidemic wave of COVID-19. Overall, our results emphasize that the theory of critical slowing down applies only when the external forcing of the system across a critical point is slow relative to the internal system dynamics. +
++Background: Monoclonal antibodies (mAbs) against SARS-CoV-2 are a promising treatment for limiting the progression of COVID-19 and decreasing strain on hospitals. Their use, however, remains limited, particularly in disadvantaged populations. Methods: Electronic health records were reviewed from SARS-CoV-2 patients at a single medical center in the United States that initiated mAb infusions in January 2021 with the support of the U.S. Department of Health and Human Services9 National Disaster Medical System. Patients who received mAbs were compared to untreated patients from the time period before mAb availability who met eligibility criteria for mAb treatment. We used logistic regression to measure the effect of mAb treatment on the risk of hospitalization or emergency department (E.D.) visit within 30 days of laboratory-confirmed COVID-19. Results: Of 598 COVID-19 patients, 270 (45%) received bamlanivimab and 328 (55%) were untreated. Two hundred and thirty-one patients (39%) were Hispanic. Among treated patients, 5/270 (1.9%) presented to the E.D. or required hospitalization within 30 days of a positive SARS-CoV-2 test, compared to 39/328 (12%) untreated patients (p<0.001). After adjusting for age, gender, and comorbidities, the risk of E.D. visit or hospitalization was 82% lower in mAb-treated patients compared to untreated patients (95% confidence interval [CI]: 66%-94%). Conclusions: In this diverse, real-world COVID-19 patient population, mAb treatment significantly decreased the risk of subsequent E.D. visit or hospitalization. Broader treatment with mAbs, including in disadvantaged patient populations, can decrease the burden on hospitals and should be facilitated in all populations in the United States to ensure health equity. +
++The prevalence of chemosensory dysfunction in patients with COVID-19 varies greatly between populations. It is unclear whether such differences are due to factors at the level of the human host, or at the level of the coronavirus, or both. At the host level, the entry proteins which allow virus binding and entry have variants with distinct properties, and the frequency of such variants differs between ethnicities. At the level of the virus, the D614G mutation enhances virus entry to the host cell. Since the two virus strains (D614 and G614) co-existed in the first six months of the pandemic in most populations, it has been difficult to distinguish between contributions of the virus and contributions of the host for anosmia. To answer this question, we conducted a systematic review and meta-analysis of studies in South Asian populations when either the D614 or the G614 virus was dominant. We show that populations infected predominantly with the G614 virus had a much higher prevalence of anosmia (pooled prevalence of 31.8%) compared with the same ethnic populations infected mostly with the D614 virus strain (pooled anosmia prevalence of 5.3%). We conclude that the D614G mutation is a major contributing factor that increases the prevalence of anosmia in COVID-19, and that this enhanced effect on olfaction constitutes a previously unrecognized phenotype of the D614G mutation. The new virus strains that have additional mutations on the background of the D614G mutation can be expected to cause a similarly increased prevalence of chemosensory dysfunctions. +
++Abstract Background The second wave of the COVID-19 pandemic hit India from early April 2021 to June 2021 and more than 400,000 cases per day were reported in the country. We describe the clinical features, demography, treatment trends, baseline laboratory parameters of a cohort of patients admitted at the All India Institute of Medical Sciences, New Delhi with SARS-CoV-2 infection and their association with the outcome. Methods This was a retrospective cohort study describing the clinical, laboratory and treatment patterns of consecutive patients admitted with SARS-CoV-2 infection. Multivariate logistic regression models were fitted to identify the clinical and biochemical predictors of developing hypoxia, deterioration during the hospital stay and death. Findings A total of 2080 patients were included in the study. The case fatality rate was 19.5%. Amongst the survivors, the median duration of hospital stay was 8 (5-11) days. Out of 853 (42.3%%) of patients who had COVID-19 Acute respiratory distress syndrome at presentation, 340 (39.9%) died. Patients aged 45-60 years [OR (95% CI): 1.8 (1.2-2.6)p =0.003] and those aged >60 years [OR (95%CI): 3.4 (2.3-5.2), p<0.001] had a higher odds of death as compared to the 18-44 age group. Vaccination reduced the odds of death by 30% [OR (95% CI): 0.7 (0.5-0.9), p=0.036]. Patients with hyper inflammation at baseline as suggested by leucocytosis [OR (95% CI): 2.1 (1.4-3.10), p <0.001], raised d-dimer >500 mg/dL [OR (95% CI): 3.2 (2.2-4.6), p <0.001] and raised C-reactive peptide >0.5 mg/L [OR (95% CI): 3.8 (1.1-13), p=0.037] had higher odds of death. Patients who were admitted in the second week had lower odds of death and those admitted in the third week had higher odds of death. Interpretation This is the largest cohort of patients admitted with COVID-19 from India reported to date and has shown that vaccination status and early admission during the inflammatory phase can change the course of illness of these patients. Strategies should be made to improve vaccination rates and early admission of patients with moderate and severe COVID-19 to improve outcomes. +
++It was observed that the multiple peaks of coronavirus disease 19 (COVID 19) appeared in different seasons in different countries. There were countries where the COVID-19 peak occurred during extremely low temperatures, such as Norway, Canada and on the other hand there were countries with high-temperature ranges such as Brazil, India, UAE. Most of the high-latitude countries received their outbreak in winter and most of the countries near the equator mark the outbreak during the summer. Most of the biological organisms have their growth dependent on the temperature, and hence we explored that if there is any relation of temperature versus COVID-19 outbreak in the particular country. It was also seen that people are not behaving differently during the peak of the COVID-19 wave, hence it was important to know whether the COVID-19 virus has evolved or the global temperature variation caused these multiple peaks. This work focuses on finding the effect of temperature variation on the COVID-19 outbreak. We used Levenberg Marquardt technique to find the correlation between the temperature at which COVID-19 outbreak peaks and the latitude of the particular country. We found that between the temperature range of 14 Degree C to 20 Degree C spread of the COVID-19 is minimal. Based on our results we can also say that the COVID-19 outbreak is seen in lower temperature (0 Degree C to 13 Degree C) ranges as well as in the higher temperature ranges (21 Degree C to 35 Degree C). The current data analysis will help the authorities to manage their resources in advance to prepare for any further outbreaks that might occur in the COVID-19 or even in the next pandemic. +
++Background: Mexico has suffered one of the highest COVID-19 mortality rates in the world. In this study we examined how socio-demographic and population health characteristics shape the geospatial variability in excess mortality patterns during the COVID-19 pandemic in Mexico. Methods: Weekly all-cause mortality time series for all 32 Mexican states, from January 4, 2015 to April 10, 2021, were analyzed to estimate the excess mortality rates using Serfling regression models. The association between socio-demographic, health indicators and excess mortality rates were determined using multiple linear regression analyses. Finally, we used functional data analysis to characterize clusters of states with distinct mortality growth rate curves. Results: The overall all-cause excess deaths rate during the COVID-19 pandemic in Mexico until April 10, 2021 was estimated at 39.66 per 10 000 population. The lowest excess death rates were observed in southeastern states including Chiapas (12.72), Oaxaca (13.42) and Quintana Roo (19.41) whereas Mexico City had the highest excess death rate (106.17), followed by Tlaxcala (51.99) and Morelos (45.90). We found a positive association of excess mortality rates with aging index (P value<.0001), marginalization index (P value<.0001), and average household size (P value=0.0003) in the final adjusted model (Model R2=76%). We identified four distinct clusters with qualitatively similar excess mortality curves. Conclusion: Central states exhibited the highest excess mortality rates whereas the distribution of aging index, marginalization index, and average household size explained the variability in excess mortality rates across Mexico. Our findings can help tailor interventions to mitigate the mortality impact of the pandemic. +
++Background: Accumulating evidence suggests that solid organ transplant recipients, as opposed to the general population, show strongly impaired responsiveness towards standard SARS-CoV-2 mRNA-based vaccination, demanding alternative strategies for protection of this vulnerable group. Methods: In line with recent recommendations, a third dose of either heterologous ChAdOx1 (AstraZeneca) or homologous BNT162b2 (BioNTech) was administered to 25 kidney transplant recipients (KTR) without humoral response after 2 doses of BNT162b2, followed by analysis of serological responses and vaccine-specific B- and T-cell immunity. Results: 9/25 (36%) KTR under standard immunosuppressive treatment seroconverted until day 27 after the third vaccination, while one patient developed severe COVID-19 infection immediately after vaccination. Cellular analysis seven days after the third dose showed significantly elevated frequencies of viral spike protein receptor binding domain specific B cells in humoral responders as compared to non- responders. Likewise, portions of spike-reactive CD4+ T helper cells were significantly elevated in seroconverting patients. Furthermore, overall frequencies of IL-2+, IL-4+ and polyfunctional CD4+ T cells significantly increased after the third dose, whereas memory/effector differentiation remained unaffected. Conclusions: Our data suggest that a fraction of transplant recipients benefits from triple vaccination, where seroconversion is associated with quantitative and qualitative changes of cellular immunity. At the same time, the study highlights that modified vaccination approaches for immunosuppressed patients still remain an urgent medical need. +
++Background: We aimed to assess the specificity of SARS-CoV-2 antibody detection assays among people with known tissue-borne parasitic infections. Methods: We tested three SARS-CoV-2 antibody-detection assays (cPass SARS-CoV-2 Neutralization Antibody Detection Kit, Abbott SARS-CoV-2 IgG assay, and STANDARD Q COVID-19 IgM/IgG Combo Rapid Test) among 559 pre-COVID-19 sera. Results: The specificity of assays was 95-98% overall. However, lower specificity was observed among sera from patients with protozoan infections of the reticuloendothelial system, such as human African trypanosomiasis (Abbott Architect; 88% [95%CI 75-95]), visceral leishmaniasis (SD RDT IgG; 80% [95%CI 30-99]), and from patients with recent malaria from a holoendemic area of Senegal (ranging from 91% for Abbott Architect and SD RDT IgM to 98-99% for cPass and SD RDT IgG). For specimens from patients with evidence of past or present helminth infection overall, test specificity estimates were all ≥ 96%. Sera collected from patients clinically suspected of parasitic infections that tested negative for these infections yielded a specificity of 98-100%. The majority (>85%) of false- positive results were positive by only one assay. Conclusions: The specificity of SARS-CoV-2 serological assays among sera from patients with tissue-borne parasitic infections was below the threshold required for decisions about individual patient care. Specificity is markedly increased by the use of confirmatory testing with a second assay. Finally, the SD RDT IgG proved similarly specific to laboratory-based assays and provides an option in low-resource settings when detection of anti-SARS-CoV-2 IgG is indicated. +
+Pulmonary Rehabilitation Post-COVID-19 - Condition: COVID-19
Intervention: Other: Exercise program (virtual/remote)
Sponsors: University of Manitoba; Health Sciences Centre Foundation, Manitoba; Health Sciences Centre, Winnipeg, Manitoba
Not yet recruiting
Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 “Long Haul” Pulmonary Compromise - Condition: Covid19
Interventions: Biological: COVI-MSC; Biological: Placebo
Sponsor: Sorrento Therapeutics, Inc.
Not yet recruiting
Mix and Match Heterologous Prime-Boost Study Using Approved COVID-19 Vaccines in Mozambique - Condition: Covid19
Interventions: Biological: BBIBP-CorV - Inactivated SARS-CoV-2 vaccine (Vero cell); Biological: AZD1222 (replication-deficient Ad type 5 vector expressing full-length spike protein)
Sponsors: International Vaccine Institute; The Coalition for Epidemic Preparedness Innovations (CEPI); Instituto Nacional de Saúde (INS), Mozambique; University of Antananarivo; International Centre for Diarrhoeal Disease Research, Bangladesh; Harvard University; Heidelberg University
Not yet recruiting
Double Blind Randomized Clinical Trial of Use of Colchicine Added to Standard Treatment in Hospitalized With Covid-19 - Condition: COVID-19 Infection
Intervention: Drug: Colchcine
Sponsor:
+Asociacion Instituto Biodonostia
Active, not recruiting
ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19 - Condition: COVID-19
Interventions: Drug: Danicopan; Other: Placebo; Drug: Remdesivir
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
COVID-19 Methylene Blue Antiviral Treatment - Condition: Covid19
Interventions: Drug: Methylene Blue; Drug: Saline nasal spray
Sponsors: Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences; Irkutsk State Medical University
Recruiting
Project FLUx COntact-CoVID-19 Faculty of Medicine Paris-Saclay - Condition: Covid19
Interventions: Other: Antigenic tests (on saliva samples); Other: Individual electronic sensor port; Other: Atmospheric measurements of CO2
Sponsor:
+Assistance Publique - Hôpitaux de Paris
Not yet recruiting
Phase I/II Study of COVID-19 DNA Vaccine (AG0302-COVID19 High-dose) - Condition: COVID-19 Lower Respiratory Infection
Interventions: Biological: AG0302-COVID19 for Intramuscular Injection; Biological: AG0302-COVID19 for Intradermal Injection
Sponsors: AnGes, Inc.; Japan Agency for Medical Research and Development
Not yet recruiting
COVID-19 Administration of Single-Dose Subcutaneous or Intramuscular Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age - Condition: COVID-19
Intervention: Drug: casirivimab and imdevimab
Sponsor:
+Regeneron Pharmaceuticals
Not yet recruiting
Reactogenicity, Safety, and Immunogenicity of Covid-19 Vaccine Booster - Condition: Covid19
Interventions: Biological: Placebo; Biological: Inactivated vaccine booster; Biological: mRNA vaccine booster; Drug: Viral vector vaccine booster
Sponsors: Universidad del Desarrollo; Ministry of Health, Chile; University of Chile; Pontificia Universidad Catolica de Chile
Active, not recruiting
Relaxation Exercise in Patients With COVID-19 - Condition: Covid19
Intervention: Other: Relaxation technique
Sponsor: Beni- Suef University
Completed
Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector, Ad5-nCoV) in Adults Living With HIV - Condition: Covid19
Intervention: Biological: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) (Ad5-nCoV)
Sponsors: Fundación Huésped; Canadian Center for Vaccinology; CanSino Biologics Inc.; Hospital Fernandez
Recruiting
Clinical Trial to Assess the Efficacy and Safety of Inhaled AQ001S in the Management of Acute COVID-19 Symptoms - Condition: Covid19
Intervention: Drug: Drug, inhalation
Sponsor:
+Aquilon Pharmaceuticals S.A.
Not yet recruiting
A Study to Evaluate the Safety and Efficacy of Artemisinin- a Herbal Supplement on COVID-19 Subjects - Condition: Covid19
Interventions: Dietary Supplement: Artemisinin; Drug: Dexamethasone
Sponsors: Mateon Therapeutics; Windlas Biotech Private Limited
Completed
Efficacy, Immunogenicity and Safety of COVID-19 Vaccine , Inactivated in Children and Adolescents - Condition: COVID-19
Interventions: Biological: Inactivated COVID-19 Vaccine; Biological: Controlled vaccine
Sponsor: Sinovac Research and Development Co., Ltd.
Recruiting
Summary report of seven cases of COVID-19 infection in renal transplant recipients - The coronavirus disease 2019 (COVID-19) has swept the world, posing a serious threat to people’s lives and health. Several cases of COVID-19 infection in renal transplant recipients (RTRs) have been reported, but the treatment and prognosis have not been fully elucidated. We followed-up with RTRs infected with SARS-CoV2 in our center and classified them as five clinical types-asymptomatic, mild, moderate, severe, and critical. The immunosuppressive agents were not adjusted in asymptomatic…
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIbeta) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus and Human Rhinoviruses - Over half a century since the description of the first antiviral drug, “old” re-emerging viruses and “new” emerging viruses still represent a serious threat for global health. Their high mutation rate and rapid selection of resistance towards common antiviral drugs, together with the increasing number of co-infections, make the war against viruses quite challenging. Here we report a host-targeted approach, based on the inhibition of the lipid kinase PI4KIIIβ, as a promising strategy for…
The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the coronavirus disease that began in 2019 (COVID-19), has been responsible for 1.4 million deaths worldwide as of 13 November 2020. Because at the time of writing no vaccine is yet available, a rapid diagnostic assay is very urgently needed. Herein, we present the development of anti-spike antibody attached gold nanoparticles for the rapid diagnosis of specific COVID-19 viral antigen or virus via a simple colorimetric…
A computational study of cooperative binding to multiple SARS-CoV-2 proteins - Structure-based drug design targeting the SARS-CoV-2 virus has been greatly facilitated by available virus-related protein structures. However, there is an urgent need for effective, safe small-molecule drugs to control the spread of the virus and variants. While many efforts are devoted to searching for compounds that selectively target individual proteins, we investigated the potential interactions between eight proteins related to SARS-CoV-2 and more than 600 compounds from a traditional…
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase - There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 (NSP13) has been identified as a target for anti-virals due to its high sequence conservation and essential role in viral replication. Structural analysis reveals two “druggable” pockets on NSP13 that are among the most conserved sites in the entire SARS-CoV-2 proteome. Here we present crystal structures of SARS-CoV-2 NSP13…
Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients - Elderly people and patients with comorbidities are at higher risk of COVID-19 infection, resulting in severe complications and high mortality. However, the underlying mechanisms are unclear. In this study, we investigate whether miRNAs in serum exosomes can exert antiviral functions and affect the response to COVID-19 in the elderly and people with diabetes. First, we identified four miRNAs (miR-7-5p, miR-24-3p, miR-145-5p and miR-223-3p) through high-throughput sequencing and quantitative…
Designing Self-Inhibitory fusion peptide analogous to viral spike protein against novel severe acute respiratory syndrome (SARS-CoV-2) - COVID-19 is a highly contagious viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is declared pandemic by the World Health Organization (WHO). The spike protein of SARS-CoV-2 is a key component playing a pivotal role in facilitating viral fusion as well as release of genome into the host cell. Till date there is no clinically approved vaccine or drug available against Covid-19. We designed four hydrophobic inhibitory peptides (ITPs) based on WWIHS…
Targeting Some Enzymes with Repurposing Approved Pharmaceutical Drugs for Expeditious Antiviral Approaches Against Newer Strains of COVID-19 - At present, global vaccination for the SARS-CoV2 virus 2019 (COVID-19) is 95% effective. Generally, viral infections are arduous to cure due to the mutating nature of viral genomes, with the consequent quick development of resistance, posing significant fatalities or hazards. The novel corona viral strains are increasingly lethal than earlier variants, as those evolve faster than imagined. Despite the emergence of several present innovative treatment options, the vaccines, and available drugs,…
COVID-19 - associated inhibition of energy accumulation pathways in human semen samples - CONCLUSION: Our results may provide molecular basis for the previously observed phenomenon of decreased sperm motility associated with COVID-19 infection. Moreover, identified data would be beneficial for the optimization of preconception care for men who have recently recovered from COVID-19.
The role of T2E mediated CBF-1/RBP-Jκ signaling in metastatic thyroid cancer - CONCLUSION: This study indicates that the overexpression of ERG co-option has a unique cis-regulatory structure in T2E positive thyroid tumors, which induces drug dependence on CBF-1/RBP-Jκ signal. Our study solved the genetic and epigenetic variation of T2E in metastatic thyroid cancer for the first time. It is worth noting that further functional and clinical validation is needed as our study is a bioinformatics analysis.
Transmissible gastroenteritis virus ORF3b up-regulates miR-885-3p to counteract TNF-alpha production via inhibiting NF-kappaB pathway - Transmissible gastroenteritis (TGE) is an acute viral disease and characterized as severe acute inflammation response that leads to diarrhea, vomiting, and high lethality of piglets. Transmissible gastroenteritis virus (TGEV), a member of coronavirus, is the pathogen of TGE. We previously found NF-κB pathway was activated and 65 miRNAs were changed in response to inflammation caused by TGEV in cell line porcine intestinal epithelial cells-jejunum 2 (IPEC-J2). Bioinformatics results showed that…
The use of pseudotyped coronaviruses for the screening of entry inhibitors: Green tea extract inhibits the entry of SARS-CoV-1, MERS-CoV, and SARS-CoV-2 by blocking receptor-spike interaction - CONCLUSION: In summary, we demonstrated that pseudotyped viruses are an ideal tool for studying viral entry, quantification of neutralizing antibodies, and screening of entry inhibitors in a BSL-2 facility. Moreover, green tea might be a promising natural remedy against emerging coronaviruses.
In Vitro Inhibition of Alphaviruses by Lycorine - Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. Lycorine, an alkaloid from Amaryllidaceae plants, has antiviral activity against a number of viruses such as coronavirus, flavivirus and enterovirus. In this study, we found that lycorine could inhibit CHIKV in cell culture at a concentration of 10 μmol/L without apparent…
Clinical Characteristics and Pharmacological Management of COVID-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia With Cerebral Venous Sinus Thrombosis: A Review - CONCLUSIONS AND RELEVANCE: Adverse events like VITT, while uncommon, have been described despite vaccination remaining the most essential component in the fight against the COVID-19 pandemic. While it seems logical to consider the use of types of vaccines (eg, mRNA-based administration) in individuals at high risk, treatment should consist of therapeutic anticoagulation mostly with nonheparin products and IVIG.
Dietary foods containing nitric oxide donors can be early curators of SARS-CoV-2 infection: A possible role in the immune system - Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is a lethal virus that causes COVID-19 (Coronavirus disease 2019), the respiratory illness that has caused the COVID-19 pandemic. Even though multiple pharmacological trials are ongoing, there is no proof that any treatment will effectively cure or prevent COVID-19. Currently, COVID-19-infected patients are being managed with non-specific medications to suppress the symptoms and other associated co-morbidities. Nitric oxide is a…
자외선살균등 - 본 발명은 사람의 의복이나 사용한 마스크 등에 부착하여 있다 호흡기로 유입되어 감염을 유발할 수 있는 COVID-19와 같은 유해균류를 간편하게 살균하기 위한 휴대용 자와선살균등에 관한 것이다. 반감기가 길고 인체에 유해한 오존을 발생하지 않으면서 탁월한 살균능력이 있는 250~265nm(최적은 253.7nm) 파장의 자외선을 발광하는 자외선램프를 본 발명의 막대형의 자외선살균등 광원으로 사용하고 비광원부를 손으로 잡고 의복이나 사용한 마스크 등 유해균류가 부착되었을 것으로 의심되는 곳에 자외선을 조사하여 간편하게 유해균류를 살균하므로써 감염을 예방하기 위한 휴대용 자외선살균등에 관함 것이다. - link
Camellia nitidissima C.W.Chi Caffeine and Chlorogenic acid composition for anti-SARS-CoV-2 and preparation method and application thereof - - link
A Novel Method COVID -19 infection using Deep Learning Based System - - link
A SYSTEM AND METHOD FOR COVID- 19 DIAGNOSIS USING DETECTION RESULTS FROM CHEST X- RAY IMAGES - - link
Mascarilla impermeable - - link
基于细胞膜展示冠状病毒免疫原以诱导中和抗体的方法 - 本申请公开了一种基于细胞膜展示冠状病毒免疫原以诱导中和抗体的方法。具体而言,本公开中提供了一种在其细胞膜表面展示新型冠状病毒SARS‑CoV‑2刺突蛋白S的细胞,包含所述细胞的针对新型冠状病毒SARS‑CoV‑2的疫苗或疫苗组合,所述细胞在制备用于预防或治疗新型冠状病毒SARS‑CoV‑2的疫苗中的应用及其制备方法。本公开的细胞和疫苗能够在体内高效活化B细胞,诱导中和抗体应答,在预防和降低新冠病毒感染中有广泛的应用前景。 - link
硫代咪唑烷酮药物在治疗COVID-19疾病中的用途 - 本发明属于医药技术领域,具体涉及一种硫代咪唑烷酮药物或其药学上可接受的盐在制备用于治疗ACE2和TMPRSS2蛋白失调相关疾病的药物中的用途,尤其是在制备用于治疗COVID‑19疾病的药物中的用途。 - link
Advanced Machine Learning System combating COVID-19 virus Detection, Spread, Prevention and Medical Assistance. - - link
一种包装重组流感病毒的重组载体和重组流感病毒及其构建方法和应用 - 本发明提供了一种包装重组流感病毒的重组载体和重组流感病毒及其构建方法和应用,涉及生物医药技术领域。本发明利用A型流感病毒八个基因片段为骨架包装出带有新型冠状病毒SARS‑CoV‑2表面刺突蛋白受体结合域(SARS‑CoV‑2_RBD)片段的重组流感病毒,此重组流感病毒可在复制过程中表达具有生物学活性和免疫原性的刺突蛋白受体结合区域RBD。本发明所述重组流感病毒rgH1N1(PR8)‑PA‑RBD可作为重组病毒类药物,用于2019新型冠状病毒肺炎(COVID‑19)的预防;也可作为体外SARS‑COV‑2 RBD等相关抗原表达和体内递呈系统。 - link
Differential detection kit for common SARS-CoV-2 variants in COVID-19 patients - - link
What Happened to Joe Biden’s “Summer of Freedom” from the Pandemic? - By banking so heavily on the vaccine and eagerly declaring victory, the President may have repeated some of his predecessor’s mistakes. - link
Andrew Cuomo’s Resignation and the Real Meaning of “New York Tough” - The Governor’s address didn’t really dispel doubts about his judgment or his character. - link
Andrew Cuomo’s War Against a Federal Prosecutor - A call to the Obama White House that some legal experts say is impeachable fits a pattern of the Governor smearing those who scrutinize him. - link
The Vindication of Andrew Cuomo’s Accusers - Charlotte Bennett, Lindsey Boylan, and Ron Kim discuss their roles in bringing about the New York Governor’s reckoning. - link
“Not Our Tragedy”: the Taliban Are Coming Back, and America Is Still Leaving - President Biden made it very clear this week that we’re out of Afghanistan, no matter what. - link
+For college students, dorm decor can showcase newly discovered identities. For parents, it can be a second nesting phase. It all adds up to a lot of shopping. +
++The “it” bag among a subset of shoppers-in-the-know is adorned with tacky logos, contains a garish combination of two primary colors, and has a kind of glitchy zipper. Despite all this, it is sometimes unavailable due to high demand. You can often find it marked up by 300 percent on third-party marketplace sites. +
++Gucci? Coach? Nope, it’s the Frakta bag, courtesy of Swedish designer … Ikea. I just bought six of them direct from the retailer, at $4.99 each. +
+The Frakta bags are made out of the same blue plasticky material as Ikea’s large open shopping bags, except they’re shaped like duffel bags and have a zipper and extra straps that can function as a backpack. I know about them from a Facebook page called Dorm Chatter, a 35,000-follower-strong bastion of mostly moms who debate the best fans, sheets, and, yes, storage bags, for moving their students to college. +
++In the early ’90s, I attended a state university with standard cinderblock dorm rooms. I decorated it with posters, milk crates, and a brown, beat-up, rented mini-fridge. So I was not fully prepared for what these amateur dorm experts were telling me my kid, who will be a freshman this fall attending college six hours away, “needed” for his room. +
++First and foremost, the Frakta bags. Group members posted tons of pictures showing how much stuff could fit in one and their superior stackability in the back of SUVs. Plus, they can have a second life as travel bags or as laundry bags. I was convinced. +
++But then it started to get more esoteric. There’s the Woozoo, a globular, oscillating fan that also moves up and down for superior cooling, which regularly sells out at Costco. There’s the Lucid mattress topper (oh, shit, he needs a mattress topper?), for which it had been determined that the 3-inch thickness was ideal. There are multiple pool noodle hacks — a shockingly popular DIY tool — including one in which you slice the noodle in half lengthwise and put it on the bottom edge of a lofted bed so taller kids don’t hit their heads on the frame. +
++There were questions about temporary wallpaper and bedskirts and even the feasibility of portable in-room washing machines. I quickly panicked, overwhelmed by the sheer amount of stuff. I had to shut my laptop and calm myself down before I mindlessly spent hundreds of dollars on over-the-fridge storage shelves and dozens of Command hooks. +
++The dorm shopping economy is a robust one, with plenty of places to buy things that you see on Instagram or TikTok or Facebook groups. In addition to Amazon, the traditional dorm retailers like Target and Bed Bath & Beyond offer dorm registries, complete with discounts. Then there are specialty retailers like OCM, DormCo, and Dormify that offer dorm-specific storage options and decor. They even sell full packages that allow students and families to buy everything all at once, like OCM’s 27-piece, $250 package that includes everything from sheets and towels to a laundry bag and surge protector. +
++Dormify, which has the trendiest products of the bunch and even offers design services, just landed a Series B round of private equity funding this spring and counts American Eagle Outfitters as a strategic investor. Social media has changed the game on dorm shopping, but also, students look to express their personalities via decor and parents see one last opportunity to take care of their children at the end of their childhoods. +
++Aaryn Peterson, a parent in Portland, Oregon, estimates she spent close to $3,000 buying stuff for her freshman daughter Grace last year. She posted a picture on the Dorm Chatter page of her in a UHaul on the last day of school surrounded by boxes, with an impassioned plea that read, in part: “Don’t be me. Learn from my mistakes.” She got almost 500 responses in return, including some sweary and defensive DMs. She says she was just trying to provide some hindsight wisdom for all of us newbies. +
++“[Grace] didn’t want 7,000 throw pillows. She didn’t want them, but I kept buying cute ones,” says Peterson. “And it was because I just kept thinking, ‘She needs this to be comfortable. She needs this to feel all the things.’” +
++I empathize with the pull of that inclination as I debate whether or not my kid needs a special bed caddy for his electronics. +
++According to a July report from consulting firm Deloitte, which publishes annual college shopping surveys, $26.7 billion will be spent on back-to- college items, an average of about $1,459 per student. Computers and gadgets make up a big chunk of this, but dorm appliances/furniture will account for $6.8 billion of the total. +
++“It’s really expensive to outfit a complete dorm. It can be thousands without really even going over the top,” says Fran Bardio, the founder of the Dorm Chatter page. The group’s first iteration was for discussing college admissions, a process she found stressful and confusing. Other parents did too, but the conversation soon transitioned into dorms, so she started Dorm Chatter separately three years ago when her first child was heading off to school. (She says she gets about 60 comments a day on the page and currently there is a queue of 1,000 people requesting page access.) +
++Typical dorm rooms are small and sparsely furnished with a desk, a closet, a small chest of drawers, and a bed that can usually be lofted to different heights. The shopping checklist my son’s school sent out was a few dozen bullet points of mostly obvious items: towels, hangers, chargers. A comprehensive document floating around on Dorm Chatter is four pages long and includes helpful items I didn’t even think about like water bottles, and things I’m not sure are really necessary, like husband pillows. Once you start getting into decor like fairy lights and ornamental headboards (more on this extremely hot item shortly), you can see how the bill can climb. +
++This is, of course, on top of ever-increasing college costs that leave many students with debilitating debt. Tuition for the 2020-2021 school year averaged $41,411 at private colleges, and $11,171 for in-state students and $26,809 for out-of-state students at state schools, according to US News data. Room and board can add thousands of dollars more to the total. +
++The McMansioning that is sometimes happening in dorms can have the unfortunate effect of mirroring the financial inequality in society. “You can definitely tell where the equity gaps are based on what someone’s room looks like. We see some people investing quite a bit of money on their residential spaces and then some who can’t afford to do that at all,” says Melantha Ardrey, the director of student life at the College of Charleston. +
++In a Reddit post a few years ago, a user said she grew up homeless for part of her childhood but was attending “one of the best colleges in the country.” This reality was highlighted before she even got to school. “The most basic dorm supplies at stores [are] incredibly out of my budget. My family and I live paycheck to paycheck so we can’t afford to spend anything else on bedsheets, a comforter, mattress topper, a pillow, toiletries, lamp, etc. It adds up so quickly!” she wrote. +
++About five years ago, highly designed and coordinated dorm rooms went viral. It’s a trend that has been popular for a while, particularly at Southern schools, per the retailers I spoke to. The concept, with the help of social media, has since trickled into the mainstream. It’s prompted the market to come up with all sorts of specialty items for dorm spaces as well as an often pricey outlook about what a dorm can be. +
++“Five years ago, it was treated more like, ‘This is like sleepaway camp for the semester.’ And now [students are] treated like adults. This is your first home away from home,” says DormCo founder Jeff Gawronski. When he was a college student in the early ‘00s, Gawronski created a bedpost shelf called the Mini Mantle, which allowed students to keep their stuff close by on a lofted bed. He sold it on campus door-to-door, then eventually launched his own company. He founded the current iteration of DormCo in 2010, and it sells everything you can imagine for a dorm room on a rather utilitarian website. +
++But Amazon, dollar stores, Target, Bed Bath & Beyond, and other big box stores are often the first stop for students of all budget levels. These places are easy and affordable. Target and Bed Bath & Beyond even offer dorm registries that come with discounts of 15 and 20 percent, respectively. Often families will register and just buy the whole order themselves at the discounted rate. While these stores have historically offered basics for dorms and a limited variety of sheets and comforters in the dorm twin XL size, they are ramping up and meeting the desire for more personalized rooms. +
++Bed Bath & Beyond, which has been struggling financially for years, is in the midst of attempting to turn around its business. Part of the strategy of the new CEO, a former Target executive, is to launch several private label brands that will likely appeal to dorm shoppers. Simply Essential is a less expensive brand for the shopper who wants basic sheets and towels. There is a storage brand called Squared Away, featuring chests of drawers and drying racks that are more stylish than the usual plain plastic fare. But the most blatant attempt to win over Gen Z is the eclectic and colorful Anthropologie-esque brand, Wild Sage. (You could be forgiven if you confuse it with Target’s Wild Fable clothing brand or its Opalhouse home decor brand.) +
++The goal is “to create a customer that we don’t have today,” says Neil Lick, the senior vice president of owned brands at Bed Bath & Beyond. Lick says that internal research showed that Gen Z doesn’t identify their decorating tastes as “modern” or “traditional,” but rather that they want their space to reflect their identities and personalities. They also are cooking more at a younger age, so the retailer is selling smaller personal blenders and other dorm-safe appliances. He says it is also marketing to that group multifunctional, smaller-scale furniture pieces, like a $150 bar cart that can be a “side table or a study area.” (The top of my ugly rental fridge was my bar cart.) +
++So ostensibly this is all meant to appeal to students, but it’s also obvious that parents and caregivers — often the ones paying for everything — are emotionally invested in their kids’ space. +
++Many students don’t necessarily care if they have a hanging tapestry that matches their throw pillows. My son told me he wanted gray sheets, but was not at all interested in discussing specific shades of gray with me. I told him about a mom on Dorm Chatter who wrote that her son never used a shower caddy because he just squirted some shampoo on his head and body wash in his hand and walked down the hall to the showers; he could relate. +
++But there are enough people who do want to personalize and organize their rooms, and investors have taken notice. Dormify is the ascendant retailer in this space, and it looks like the Gen Z child of Instagram, Pinterest, and Glossier. Pictures of beautiful dorm tableaus on the site feature fluffy pillows and neon signs announcing “GRL PWR.” +
++Dormify offers room “stylists,” has IRL pop-ups in several cities like Boston, Chicago, and New York City where you can make a styling appointment, and has virtual tools that allow shoppers to see what all the pieces will look like in a room. “That combination of an e-commerce platform with a comprehensive solution and the engagement factor was something that we didn’t see out there,” says Lisa Myers, the co-founder and managing partner of Clerisy, the firm that invested an undisclosed amount in Dormify in March. +
++Plus, just like the bridal market, there is a never-ending supply of new customers. “You get 2 million new college students who you reload the gun with every year. Not to mention the 18 million across the country that are in college over the four years,” she says. She hints that the brand aims to stay with these young adults as they finish college and enter starter apartments. +
++Amanda Zuckerman founded Dormify with her mom in 2011 while she was still in college, growing a blog about college life and dorm decor into a business. As a student, she was into fashion and couldn’t find stylish, fun bedding in the twin XL size. She partnered with American Eagle in 2015, when the retailer was interested in making home goods for the Aerie brand. It invested $3.45 million in the company in 2018. Dormify has grown from there thanks to a commitment to engaging with its customer cohort on social media and active recruitment of influencers to work with the brand. +
++Zuckerman says the typical Dormify customer is finding inspiration from the social media accounts of older influencers. “From an aesthetic standpoint, there has definitely been a shift. Twelve-year-olds think they’re 25, and18-year-olds want to be 30. Everyone just wants to be super sophisticated and much older than they actually are,” Zuckerman says. So they’re aspiring to the homes of influencers like Danielle Bernstein/We Wore What and Emma Chamberlain. Dormify attempts to translate the aesthetic into attainable bedrooms. They also partnered on a collection with Katie Feeney, a TikTokker with over 6 million followers who is headed to Penn State as a freshman this fall. +
++Headboards ($99 to $199) — fluffy, tufted, textured — have become bestsellers for Dormify. They’re never discounted. The ones the site sells attach to the wall via velcro strips or Command hooks, and many feature charging stations. Zuckerman says customers often buy headboards before they even decide on a color scheme. White faux-fur pillows are perennial bestsellers. Must-have lighting includes both a desk and floor lamp, but now decorative strings and LED strips are de rigueur as well. Removable wallpaper that looks like faux bricks has also been flying off the shelves. And gray everything, much like in the larger home decor world, refuses to go away. +
++It’s easy to mock all this blatant consumerism for a temporary room that someone may live in for less than a year. And I have certainly mocked myself for getting influenced. But there are some strong psychological and developmental phenomena at play here that these retailers have been brilliant at exploiting or supporting, depending how cynical you want to be about it. +
++First, there’s a bit of helicopter parenting, something I have enough self-awareness to realize. I’m far from alone here, though. Of the dorm move-in and decorating process, “We definitely have had more parental involvement over the years. This is sort of a generational change that we’ve seen,” says Ardrey of the College of Charleston. +
++So many moms on Dorm Chatter have noted that all this frenetic gathering on behalf of our children feels like a second nesting phase, akin to the one many parents go through when they are pregnant. To me, making sure my son has new shower flip flops and a convenient laundry bag feels like a final, momentous caretaking task. +
++“It’s this weird emotional time. You’re so proud of them, but yet you want to hold onto the life that you knew and it’s never going to be the same. Your kid’s not going to be with you for the daily interactions. So it takes a very emotional toll on parents,” says Bardio, the Dorm Chatter founder. +
++For the young adults going out on their own for the first time, they want to visually show off their identities via their living spaces. It’s often the first test of their newfound independence. Bed Bath & Beyond’s consumer research led them to conclude that for this generation “the importance of your space as a nurturing escape from the world or a place you’re proud of combined with the ability to show off and share your space with the world has put the importance of dorm decor more on the radar than ever before.” +
++Mychelle Oliver, a student at Kent State, was excited to decorate her dorm. She used graduation money to shop at Target, Home Goods, Dormify, and home decor store Kirkland’s, where she worked and had an employee discount. She scrolled through Pinterest and watched dorm tours on YouTube for ideas, and credits her mom with having an interior designer’s sensibility. +
++“It made me feel very independent, and I have always loved decorating. It was like serotonin when I was able to decorate something,” Oliver wrote in an email. “The level of decor compared to my friends’ and peers at school was to the extreme lol… They were always amazed how I made a small, empty room into something I called a second home.” +
++But yes, it all adds up to a ton of shopping. +
++“We’re making ourselves sick trying to make sure that our kids have this Disney World experience every single day that they’re at college. It’s not necessary,” says Peterson, the mom from Portland who wrote the Facebook post arguing against buying too much. “They just want to experience college.” +
++But I still bought the Woozoo fan. +
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++On Vox Conversations, the Berkeley professor and former secretary of labor speaks about changing the world not inside government, but on your timeline. +
++Back in 2002, during his run for Massachusetts governor, Robert Reich put out a book called I’ll Be Short. The title recognized the elephant in the room, so to speak: Reich, a former secretary of labor under Bill Clinton, stands just under five feet due to a rare genetic disorder that stunted his growth, and was running for major office in a country that likes tall politicians. He lost that race, but nearly 20 years later, Reich’s message of equality and societal cooperation is resonating more loudly than perhaps ever before. +
++Reich is the author of numerous other books, most recently The System: Who Rigged It, How We Fix It. Now 75 and a professor at Berkeley, his truculent tweets and social videos are at once blunt and inviting, humorous and uncompromising. I wanted to talk with Reich about the growing inequality he fights against, political dynamics in Congress, and how social media allows him to serve as an educator outside of the classroom. +
++He and I spoke on August 2, shortly after two titans of industry spent absurd amounts of money to joy-ride to the edge of space, and only for mere seconds. Given Reich’s frequent critiques of oligarchs, I couldn’t wait to hear what he thought of that. +
++An abbreviated transcript, edited for length and clarity, follows. You can hear much more of our chat in this week’s episode of Vox Conversations, embedded below. +
++Subscribe to Vox Conversations on Apple Podcasts, Google Podcasts, Spotify, Stitcher, or wherever you listen to podcasts. +
++Amidst all of this worry about folks who are having trouble just keeping a roof over their heads, we have a couple of rich guys trying to go to space. It’s this kind of dick-measuring contest between Richard Branson and Jeff Bezos. I hesitate to reach into somebody else’s wallet, but what else could they be doing with that money? +
++Look, you can always make up a story, isn’t this great, we are moving closer to space travel for ordinary people. I think that’s bullshit, frankly. Ordinary people are not going to go into space at least in my lifetime — maybe your lifetime. It’s kind of a symbol of something that runs very deep in capitalism. And that is the very wealthiest seceding from everybody else. +
++Today, to be rich in America is not to have to come anywhere close to anybody who is not rich. You have your own private planes, your own security guards, your own limousines, your own drivers, everything is privatized, and you only see other rich people. The logical extreme, symbolically, is a space colony of only rich people. +
++But in this respect, how are rich people dangerous? +
+Well, they’re not so dangerous. They’re just not paying their fair share of the dues, for being a part of a society and a part of the world. And I think they’re also kind of thumbing their nose at society. They’re saying, “We can live in our own world, we can go into outer space, we can do anything we want, we have the ultimate freedom. And by the way, you guys don’t.” +
++That’s something I think you addressed very well in one of your earlier chapters in your book last year, with regard to how the rich get to enjoy socialism — and the rest of us have to deal with the consequences of capitalism. +
++I think this is a very fundamental, important point that distinguishes American capitalism from almost every other form of capitalism. Here we have the harshest and most brutal form of capitalism. We have almost no safety nets. Our safety nets that we did have are unraveling. +
++If you are poor, if you’ve had bad luck, if you’ve had a bad illness, you’re in terrible trouble. You are constrained in ways that almost nobody else in the world, in advanced countries, is constrained. We have no sick leave. We have no mandatory paid paternity or maternity leave. We have no child care. We have nothing for most people except Social Security and Medicare. But if you are rich, if you have rich parents, if you’ve had the best luck, if you if you’ve gone to good schools and you have the right connections, you are in a different, and it’s a socialist world in the sense that you’re too big to fail, too rich to fail. +
++The government will bail you out if you’re a banker and you have completely screwed up. You get tax breaks. The Federal Reserve Board will give you extra benefits and we’ll take the debt off your hands. You’ve got enough political power to get everything you want. +
++And that’s the thing I don’t understand, going back to the Democrats: You have the power, you have the presidency back, you’ve rescued it from these incompetent, malevolent people who were in charge and you have a majority in Congress. Why aren’t you using it? +
++I want to say, in just fairness, I’m impressed by the stimulus bill that got through. I’m impressed that an infrastructure bill is going through. I think the Democrats actually are accomplishing more than the Obama Democrats or the Clinton Democrats in the first two years. +
++But as a progressive, I want more. I want to see the minimum wage raised. I want people who are in poverty, who are in who are being kicked out of their homes or their rental units. I don’t want people at the border to be put into prisons or jails or cages. As a progressive, as a liberal, I want much more than the Democrats seem to be able to deliver. I want voting reform. And I’m angry. +
++There’s this kind of partisan theater that sometimes takes us away from what we need to be focusing upon. You’ve been in Washington as the labor secretary. You’ve filled a lot of different roles in our politics. +
++Is working with Republicans even worth it? +
++I would say now, probably not. I was in Washington at a time when it was possible for Democrats and Republicans to come together. There was a generation of people who had gone through some traumas: the Vietnam War, voting rights, civil rights. They had been forced to work together. They had been through the Nixon administration. +
++They understood they needed each other. They understood they were there for the common good, for the country as a whole. That is now not the case. The Republican Party essentially stands for two things for the two basic parts of its constituency: low taxes for the wealthy and white supremacy for the white working class. +
++And Republicans exploit that to maintain power because they can’t win national elections anymore, especially the presidency. And they certainly can’t do it without huge amounts of voter suppression. +
++Oh, yeah, that’s the key to their survival. And I think they’re playing with long-term debt. +
++They got people scared about using their full capabilities as a citizen. It’s not simply targeting the undocumented folks, but also the people who are here legally but aren’t, in Republican views, fortunate enough to be white. And they want to make sure that those people, even though they are here legally and they are citizens, feel like they aren’t fully part of the American franchise. +
++And that is inherent to the whole philosophy because if you make people feel like they’re not fully Americans, it’s easier to dehumanize them. And it makes their job easier, in terms of maintenance of power for the service of oligarchy. +
++Absolutely true. I think the oligarchy in America wants black people and white people, working-class, to distrust each other, even hate each other. That way they prevent the working class and much of the middle class from looking up and seeing where all the wealth has gone. That is the central goal, I think, of the richest people in America. +
++And of course, that’s who we’re speaking about. When we talk about oligarchy, we don’t have dukes and kings and queens in this country. But money allows folks to assume those kinds of de facto royalty positions within our society. +
++I look at the fact that we’ve always had an oligarchy. We’ve always had a lot of inequality in this country. But the last time we had the degree of inequality was in the so-called Gilded Age, where a handful of extraordinarily wealthy people suppressed votes. They suppressed unions. They did not want any competition for their fortunes. And, of course, it ended badly. +
++So what’s the bottom line? It is interesting. It’s actually in the economic interest of the oligarchy of the wealthy to prevent and to cure the degree of inequality we now have. They are raking it in, but the next depression is just around the corner. +
++And they don’t see it. They don’t understand that they would be doing better, that white supremacy hurts us all, and so does their employment of white supremacy and its tactics in order to preserve power. +
++But also, I think Republicans and oligarchs understand race and racism in this country probably better than a lot of Democrats do. What do you think about how our evolving attitudes on race and racism and misogyny and other forms of discrimination and bias have affected how Republicans seek to retain power? +
++What I don’t think we faced is that there’s a connection between racism and the maldistribution of income and wealth in this country. We haven’t faced the fact that voting rights are not simply a matter of making sure that everybody can get to the polls. Voting rights is also a matter of making sure that our government is not overwhelmed by big money. +
++There are so many different things that would make this a better country, and make it run more efficiently and more equitably. What do people need to do right now? For voting rights, for the minimum wage, for all of it put together. And if not taking to the streets, what do you feel might be the best way for us to go after these goals? +
++Well, it’s always nice to take the streets, but I worry that demonstrating is sometimes a substitute for the hard work of political organizing. And it mustn’t be. I tell my students that the best way to make change is to help people organize for change. The best way to improve society is to either run for office yourself or to get other people to help support candidates in your communities, in your states. Organize, organize, organize. That’s what needs to be done all over the country. +
++I don’t want to be understood as pooh-poohing demonstrations. But we really do need people who are working the political system, who have a very long view. This is not going to happen in one year. It’s not going to be happening over one election cycle. +
++Now, let me just say one more thing: I am very sympathetic with people who come to me and say I’m burnt out. You know, I’ve just been banging my head against a wall, trying to make change, trying to make social change that is progressive. And I can’t do it anymore. Yes, of course, I understand that. I feel the same way. +
++But often, people who are burnt out have been doing it the wrong way. They’ve been taking too much responsibility on themselves personally. They’ve not been allocating responsibility to others. They’ve not been policing themselves. They’ve not been thinking about the long term. +
++One of the things I think about when you mention that is how burnt out we all got over the previous four years in this administration, just the constant onslaught of bad news, of vitriolic speech, of defending the indefensible. And I think that speaks to your assertion that people take too much upon themselves. They feel like they [must be watching] CNN and MSNBC 24/7 and reading every article. And I keep telling people, “I’m in this business. I used to work in cable news. I don’t watch it anymore.” +
++I think the biggest danger, honestly, is not burnout. The biggest danger is cynicism. If many of us and by us, I mean progressives who care about this country, who want social change, who believe in the ideals of this country, if too many of us just say no way, this is not going to happen, then it won’t happen. +
++And that’s what the oligarchs and the white supremacists would really want more than anything else. They want us all to feel that nothing is going to change. Because if we give up, then we cede the entire ground to them, and we must not do that. Anger isn’t bad. We can be outraged. That’s not bad. But let’s not be cynical. +
++++@rbreich + ++Folks, there is nothing radical about forming a society based on justice and dignity. +
+♬ Pretty young twearkalator - ✨yUh✨ +
+In that respect, I think you’re an early adopter of common sense. How do you feel like you’re now using your platforms, whether they be in the classroom at Berkeley or on Instagram and YouTube? How are you trying to reach people, to further the kind of change that we need? +
++I consider myself an educator. I mean, that’s what I do. I think people need to understand context. They need to be able to connect the dots, economics, politics, philosophy, history, law, and I guess my faith is that to the extent that they are able to do this, they will be constructive citizens. +
++So my little contribution now is to teach. I love my students. I love teaching, and to teach through social media. Books are a very difficult and inefficient way of reaching people these days. I don’t want to sound negative about young people. I think they’re acutely sensitive to visual cues, and they’re acutely sensitive to musical cues. They grew up not geared to nearly as much the written word as my generation was. And again, I want to stress that my generation cannot see and hear nearly as well as young people. +
++I even started to do something on TikTok. Now, I don’t understand tech. I really don’t. +
++You and me both. +
++We’re not grandiose here. We’re talking about little-scale reaching, reaching generations. So that’s great. +
++You’ve got to continue to fight. I don’t say this out of cynicism. I see this out of hope, because I believe that a good society is a society that understands that these battles never end. A good society has got to continuously train young people to fight these fights, for some of them to devote their entire lives to these battles. You don’t expect everybody, but maybe 1 or 2 percent. Because these are the front lines in the maintenance of democracy. +
++Speaking of someone who was on the front lines: Tell the listeners who Michael Schwerner was, and who he was to you. +
++Well, it’s hard for me to talk about this, because I almost always get emotional. I mean, everybody has their own story about why they do what they do. And my personal story involves Michael Schwerner, because when I was a kid, I was very short. I still am very short, and I was bullied. And my defense against this was to find older boys who would protect me. I kind of created my own private protection racket. +
++And Mickey Schwerner, when I was a kid, was one of the older boys who did help me. And then in the summer of 1964, I learned later that Michael Schwerner had been in Mississippi, registering black people to vote, along with two other civil rights workers, when he was brutally murdered. By the Ku Klux Klan, including the sheriff of the county. +
++And when I heard that my protector had been tortured and killed, I think my life changed. I think I started to see that power was a central animating force in a society, in ways that I didn’t understand until then. And that stopping the bullies, whether they’re economic bullies or financial bullies or political bullies, is what we must do if we’re going to have a good society. +
++
++You shouldn’t need TurboTax to file your taxes. The IRS can and should make its own service. +
++The next big Joe Biden spending package is coming: This week, the Senate narrowly passed, on party lines, a budget resolution designed to enable as much as $3.5 trillion in new spending over 10 years. +
++Congressional Democrats say the spending package will be paid for, and they have been clear about one of the main sources of funding: the IRS. The Biden administration has proposed an $80 billion funding boost to the agency over 10 years as part of its “American Families Plan,” an increase of more than 50 percent to the agency’s normal budget. The Biden team estimates that could raise nearly $700 billion over that same period, paying for itself nine times over. That could fund a huge number of other Biden initiatives, from an enhanced child tax credit to paid family and medical leave to child care assistance. +
+But it could also pay for an improvement to the tax system itself. While no one in the administration or Congress seems to be making much noise about this, the IRS funding plan could be a golden opportunity to force the agency to join the rest of the world in offering a free, easy-to-use service that all Americans can use to file their taxes. +
++The timing is auspicious for such an endeavor. As you may know, if you make $72,000 or less, you’re eligible for a free return through the IRS Free File program, including software provided by Intuit, the company that operates TurboTax. If you make more, you’re eligible for Free File Fillable Forms, an Intuit product. +
++That system is now falling apart. Intuit is pulling out of its arrangement with the US government, which could mean the end of the only online tax filing systems available free of charge to all Americans. +
++But this collapse may present an opportunity. +
++For decades, the tax prep industry has succeeded in preventing the IRS from doing what the tax authority in just about every other country does: providing a free, effective, easy-to-use online service where all taxpayers can file their taxes. But it’s doing so just as the Biden administration is attempting to pour billions in new funding into the IRS. +
++The end of Free File and the conversations in Congress around IRS funding could make this the perfect moment to dismantle our broken tax filing system and build something better. +
++Right now, if you’re an American who wants to file your taxes without paying any additional fees to a private company or preparer, you have three options (besides limited “simple return” promotions by the big companies). +
++You can role-play as someone living in the 1970s and print out the 1040 tax form, along with any associated schedules or forms for tax credits and deductions for which you may be eligible, and compute it all by hand, meticulously collating physical copies of your W-2 and 1099 income statements and any other documentation you need. +
++Your second option is only slightly less tedious: You can use Free File Fillable Forms, a free service implemented by Intuit that simply copies the physical IRS tax forms and makes them “fillable” so you can type in the numbers. It’ll even do some basic math for you. But you still have to manually enter everything, you can’t import PDFs of your W-2 or other statements, and it’s easy to get confused about exactly which forms you’re expected or required to fill out. I’m an IRS-certified tax preparer, and I gave up using the website this year out of frustration. +
++Your final option is only available if you make $72,000 a year or less. In that case, you’re eligible for a free return on private tax software through the IRS Free File program. But careful: You might get a ton of spam from whatever company you choose trying to upsell you and get you to pay for fancier options. One investigation found that 14 million Americans were charged by companies for Free File returns that should have cost nothing. +
++The IRS also funds community tax organizations that can file returns for low-income people, but I can say from experience as a volunteer tax preparer that these groups are underfunded and overworked. +
++This is an unacceptable state of affairs. Americans should not have to choose between these obviously inadequate and half-baked free options for tax filing and paying a private company. Paying taxes is a legal requirement, and it should be possible to easily do it for free. And it just isn’t possible right now; it’s no wonder that over 91 percent of individual returns filed in 2019 were filed through a paid preparer or a private online service. The current system almost forces you to pay for the privilege of paying your taxes. +
++The Free File and Free File Fillable Forms systems can perhaps best be understood as a kind of peace treaty between the IRS and the private tax preparation industry, specifically Intuit and H&R Block. +
++For years, the government leaned on those two companies to provide free tax services to Americans in need. But the basic problem with relying on private sector companies that provide paid tax services to provide free ones is that they will always have an incentive to make the free service worse and to make the paid one more attractive. That’s been the story the past couple of decades. +
++In 2002, as part of a broader effort to improve government technology to take advantage of the internet, the Bush administration proposed that the IRS develop “an easy, no-cost option for taxpayers to file their tax return online.” +
++This, as ProPublica’s Justin Elliott and Paul Kiel reported, led to a massive lobbying push from Intuit, including a coordinated letter from Republican members of Congress demanding that the IRS not “compete” with private companies, with an implicit threat of reduced IRS funding if it did try to offer free filing. +
++So the IRS, hamstrung by limited funding to start its own free filing program anyway, negotiated a deal with the tax preparers: The companies would offer low-income Americans free tax prep software, and in exchange, the IRS would promise not to set up a free filing program of its own. +
+ ++This is the system that has held from 2002 to the present. The IRS brags that 70 percent of Americans are eligible for Free File, but for the 2019 tax season, only 4.2 million returns out of 157.2 million total were filed through Free File, or 2.6 percent. +
++H&R Block and Intuit succeeded in making the program a non- entity. In 2019, Elliott and Kiel began documenting how the two companies were undermining Free File, from hiding their Free File options from Google results to tricking their clients into paying when they could file for free. +
++Their reporting led by the end of the year to significant changes to the Free File program. The IRS added an addendum to its deal with tax preparers. The new provisions prohibited companies from blocking Free File search results and tried to reduce deceptive marketing, and, more crucially, dropped the ban on the IRS developing its own free file option. +
++This, perhaps unsurprisingly, led to backlash from the tax prep industry. +
++Last year, H&R Block became the first preparer to leave the Free File Alliance, meaning it would no longer provide free returns to all low-income Americans through the program. Intuit followed suit this July by announcing it would pull TurboTax from the program as well. +
++This doesn’t entirely gut the program — other services like TaxSlayer and TaxAct are still available — but it removes the program’s two most popular service providers. Most importantly, Intuit’s withdrawal throws the future of Free File Fillable Forms, which it develops for the Free File Alliance, into question. +
++This chaos is particularly important for low- income people. Some of America’s most important safety net programs exist as parts of the tax code, in particular the earned income tax credit (EITC) and the child tax credit (CTC); so did the economic impact payments, better known as “stimulus checks,” last year. Having access to a free program to file taxes and access these credits is consequential for a lot of families. +
++But this chaos could also provide an opening for something better. +
++The IRS desperately needs to put together an easier-to-use, simpler way for people to file their taxes and access benefits free of charge. Accomplishing that, of course, is easier said than done. The IRS has been underfunded for decades and does not have sufficient in-house technical expertise to build a free file system on its own. +
++But there are signs suggesting that the limitations keeping the IRS from enabling free filing are falling away. +
++First, the agency removed the ban limiting it from offering such a product in 2019. Then the Biden administration made increased funding to the agency one of its top domestic spending priorities, as well it should — funding the IRS increases tax revenue and pays for itself several times over. While the provision fell out of the bipartisan infrastructure deal over Republican opposition, it’s set to be used as a pay-for in Democrats’ $3.5 trillion spending package. +
++That could provide the funding necessary for the IRS to make free filing a reality — and Intuit’s withdrawal from the Free File program could provide some sense of urgency. “The problems with Free File lead me to conclude that it is time for IRS to develop the technology that will allow individuals to access our tax system with minimal burden,” Leslie Book, a professor of tax law at Villanova, told me, in a judgment that echoes many tax law experts I’ve spoken with. +
++In the near term, the IRS will need a stopgap measure for free tax returns next spring, especially if no provider in the Free File Alliance steps up to replace Intuit in running Free File Fillable Forms. The IRS will likely not have funding and staffing in time to set up an in-house program by then, which means that on a temporary basis it will likely have to repeat the Free File formula of relying on private preparers. +
++Daniel Hemel, a professor of tax and constitutional law at UChicago, has proposed a simple temporary fix: have the US government pay TaxSlayer, TaxAct, or any of the other remaining Free File companies on a per-return basis to prepare returns for taxpayers, at least low-income ones. +
++++Congress would say: “Hey TaxSlayer, FreeTaxUSA, & anyone else who wants to get in on the game: We’ll pay you $10 for every valid Form 1040 w/adjusted gross income <$100k e-filed via you, provided you also allow the taxpayer to file a free state return” 2/ +
+— Daniel Hemel (@DanielJHemel) July 21, 2021 +
+Hemel notes that while this isn’t the same as having the IRS do things in-house, it’s also an improvement on the Free File model, in which tax preparers aren’t compensated at all for Free File returns and thus have tremendous incentive to upsell. “Under Free File, companies have literally nothing to lose if they try to upsell & then you quit,” Hemel writes. “Now, they’d be losing out on real revenue.” +
++In the long run, though, there’s no reason to compensate private firms on a per-return basis. What the government could do instead is build its own free-to-use software for tax filers. +
++Nina Olson, who served from 2001 to 2019 as the national taxpayer advocate, a position in the IRS advocating for taxpayers and for improved customer service, has been proposing this for years, and today argues for it as executive director of the non-government Center for Taxpayer Rights. +
++Here’s how it would work: The IRS would start by putting out a request for proposals (RFP) for a new system to be built by private software/IT firms. That RFP could lay out a replica of today’s system, with full-featured software for low-income people and Free File Fillable Forms for others. But it could also just make the full-featured software available to everyone — and should, in my opinion. +
++It could also create a simplified system for people who don’t owe taxes but are owed the earned income tax credit or child tax credit, to keep the IRS updated on how many children they have and what they’re earning so they can receive their full benefits. +
++As part of this process, the government would likely lean heavily on some in-house technical expertise. Groups like the US Digital Service, housed in the White House, and Technology Transformation Services, a division of the General Services Administration (GSA) that provides technical assistance to federal agencies are home to software engineers and project managers who can help with designing the RFP and the procurement process. +
++“What Intuit’s leaving has done is created the momentum. There’s a vacuum now. The IRS is going to have to take some action. It’s an opportunity for US Digital Services etc. to see if they can be of assistance,” Olson says. +
++The IRS could also go a step further from just free filing and experiment with pre-filled returns, an idea that has been floating around tax policy circles for decades. +
++The actual work of doing your taxes mostly involves rifling through various IRS forms you get in the mail. There are W-2s listing your wages, 1099s showing miscellaneous income like from one-off gigs, etc. The main advantage of TurboTax is that it can import these forms automatically and spare you this step. +
++But here’s the thing about the forms: The IRS gets them, too. When Vox Media sent me a W-2 telling me how much it paid me in 2020, it sent an identical one to the IRS. When my bank sent me a 1099 telling my wife and me how much interest we earned on our savings account in 2020, it also sent one to the IRS. If I’m not itemizing deductions (like 70 percent of taxpayers), the IRS has all the information it needs to calculate my taxes, send me a filled-out return, and let me either send it right back to the IRS if I’m comfortable with their version or else do my taxes by hand if I prefer. +
+ ++This isn’t a purely hypothetical proposal. Countries like Denmark, Sweden, Estonia, Chile, and Spain already offer ”pre-populated returns” to their citizens. California experimented with a version called ReadyReturn before it was shut down under pressure from H&R Block and Intuit. +
++Olson notes that an RFP from the IRS could demand that a free-file option enable pre-filled returns or, at the absolute least, automatically import forms that have been sent to the IRS associated with your or a family member’s Social Security number. +
++The steps needed from here are simple. +
++Congress needs to authorize more funding for the IRS. It also ideally would pass the Tax Filing Simplification Act, a proposal dating from 2017 and championed by Sen. Elizabeth Warren (D-MA) that would order the IRS to put together a free-filing system and to offer pre-filled returns. The act could perhaps be included in Democrats’ forthcoming budget reconciliation bill. +
++The hardest steps toward simplification would involve fixing the tax code itself. In 2019, Olson in her capacity as national taxpayer advocate enlisted Book and other experts to propose changes to make tax code benefits easier to access. They proposed simplifying the earned income tax credit so it was paid out without reference to how many kids a worker has, which could make it easier to pay out over the course of a year rather than at tax time. In exchange, the child tax credit would be enhanced and made bigger, which President Biden has already made steps toward. +
++A reform like this could make tax filing totally unnecessary for most low-income people. Eliminating breaks like the mortgage interest and charitable deductions would make returns unnecessary for most middle- and upper-middle-class people too. +
++But those are heavy lifts. A huge first step would be to simply fund the IRS adequately, have it pay private tax preparers to process returns for now, and have it hire a software firm to build a real free-file system with pre-filled returns. That would eliminate the tax prep industry’s stranglehold on our tax system and make the entire process vastly easier for Americans, especially low-income Americans. +
++
+Olympic medal effect: Mirabai already seeing heightened interest in weightlifting - Star weightlifter Mirabai Chanu has observed a heightened interest in the power sport since her silver medal-winning feat at the Tokyo Olympics and ex
England team’s first tour to Pak since 2005, to play two T20s before T20 World Cup - The England squad will return for another limited-overs series and World Test Championship matches next year.
Neeraj’s coach Klaus says going forward, aim is to be “stable” in technique - Klaus Bartoneitz said when he took Chopra under his wings in 2019, he knew the Haryana lad has it in him to become a top thrower in the world.
Chennaiyin FC signs Davinder - The 25-year-old Indian international will be eager to get back on the field after missing the last three editions of the ISL due to a knee injury.
Sometimes, it feels like a dream: Princepal Singh on his NBA journey - Princepal Singh is the first NBA Academy India graduate to feature in a Summer League game
BJP’s ‘two gentlemen’ will lock down Parliament if they have their way, says Chidambaram - The Chair in both Houses was “not as neutral as it should be”, said former Union Minister Chidambaram.
BJD announces 27% quota for OBC candidates in next panchayat election - Party delegation meets Home Minister Shah for caste-based census, lifting of 50% ceiling on reservations
Ladakh Lieutenant Governor Mathur inaugurates 10 ‘water ATMs’ in Leh - The Lieutenant Governor directed the department to develop both Leh and Kargil cities at par with the top cleanest cities in the country.
Rare turtles rescued in Maharashtra return to Assam - They reached Guwahati after an 18-hour flight in padded plastic boxes
Mysuru-Chennai flight revived - Indigo to operate three flights a week
Turkey floods: Death toll near Black Sea rises to 27 - Flash floods in northern Turkey are the country’s second natural disaster this month.
Plymouth shooting: Jake Davison deadly spree took 6 minutes - Jake Davison killed five people, including a young girl, in Plymouth before turning the gun on himself.
Romelu Lukaku: Chelsea re-sign Belgium striker from Inter Milan for a club record £97.5m - Chelsea have re-signed Belgium striker Romelu Lukaku from Inter Milan for £97.5m.
Russia holds hypersonic flight expert in spy probe - Alexander Kuranov, detained by FSB agents, runs a team of pioneering spaceflight researchers.
Covid: Germany fears thousands got saline, not vaccine from nurse - More than 8,000 mostly elderly people are urged to get vaccinated again as a nurse is questioned.
Excerpt: How Google bought Android—according to folks in the room - Enjoy a sneak peek from Androids: The team that built the Android operating system. - link
Rocket Report: NASA installs SLS software, India’s GSLV fails to reach orbit - “I was really expecting to see a slowdown in the number of new launch vehicles.” - link
Free Guy review: Finally, an authentic gaming film—and it’s fun, not perfect - The film’s gaming focus has a few issues, but Reynolds, Comer captivate as leads. - link
Russia’s space program just threw a NASA astronaut under the bus - “The Americans refused to perform a polygraph examination.” - link
School mask battles rage on as more children fall ill, fill hospitals - Even with the delta-variant surge, masks and adult vaccinations keep kids safe. - link
+The monks graciously accept him, feed him dinner, even fix his car. As the man tries to fall asleep, he hears a very strange sound. The next morning, he asks the monks what the sound was, but they say, We can’t tell you. You’re not a monk. +
++The man is disappointed but thanks them anyway and goes about his merry way. Some years later, The same man breaks down in front of the same monastery. The monks again accept him, feed him, and again fix his car. That night, he hears the same strange noise that he had heard years earlier. The next morning, he asks what it is, but the monks reply, We can’t tell you. You’re not a monk. +
++The man says, All right, all right. I’m dying to know. +
++If the only way I can find out what that sound was is to become a monk, how do I become a monk? +
++The monks reply, You must travel the earth and tell us how many blades of grass there are and the exact number of sand pebbles, when you find these numbers, you will become a monk. The man sets about his task. Some 54 years later, he returns and knocks on the door of the monastery. +
++He says, I have traveled the earth and have found what you have asked for. There are 145,236,284,232 blades of grass and 231,281,219,999,129,382 sand pebbles on the earth. +
++The monks reply, Congratulations. You are now a monk. We shall now show you the way to the sound. +
++The monks lead the man to a wooden door where the head monk says, The sound is right behind that door. The man reaches for the knob, but the door is locked. +
++He says, Real funny. May I have the key? The monks give him the key, and he opens the door. Behind the wooden door is another door made of stone. +
++The man demands the key to the stone door. The monks give him the key, and he opens it, only to find a door made of ruby. He demands another key from the monks, who provide it. +
++Behind that door is another door, this one made of sapphire, And so it went until the man had gone through doors of emerald, silver, topaz, and amethyst. +
++Finally, the monks say, This is the last key to the last door. +
++The man is relieved to know that he has finally reached to the end . +
++He unlocks the door, turns the knob, and behind that door he is amazed to find the source of that strange sound. +
++But he can’t tell you what it is because you’re not a monk. +
+ submitted by /u/Dark_Sunsh1ne
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+A wife decides to take her husband to a strip club for his birthday. +
++They arrive at the club and the doorman says, “Hey, Dave! How ya doin’?” His wife is puzzled and asks if he’s been to this club before. +
++“Oh no,” says Dave. “He’s on my bowling team.” +
++When they are seated, a waitress asks Dave if he’d like his usual and brings over a Budweiser. His wife is becoming increasingly uncomfortable and says, “How did she know that you drink Budweiser?” +
++“She’s in the Ladies’ Bowling League, honey. We share lanes with them.” +
++A stripper then comes over to their table, throws her arms around Dave, and says “Hi Davey. Want your usual table dance, big boy?” Dave’s wife, now furious, grabs her purse and storms out of the club. +
++Dave follows and spots her getting into a cab. Before she can slam the door, he jumps in beside her. He tries desperately to explain how the stripper must have mistaken him for someone else, but his wife is having none of it. +
++She is screaming at him at the top of her lungs, calling him every name in the book. +
++The cabby turns his head and says, “Looks like you picked up a real bitch tonight, Dave.” +
+ submitted by /u/katsrin
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+A farmer went to a local bar and ordered a glass of champagne. The woman sitting next to him said, ‘How about that? I just ordered champagne, too!’ ‘What a coincidence’ the farmer said. ‘This is a special day for me. I am celebrating.’… This is a special day for me too, I am also celebrating,’ said the woman.’ ‘What a coincidence!’ said the farmer. As they clinked glasses he added: ‘What are you celebrating?’ ‘My husband and I have been trying to have a child and today my gynaecologist told me that I am pregnant!’ ‘What a coincidence!’ said the man. ‘I’m a chicken farmer and all last year my hens were infertile, but today they are all laying eggs again.’ ‘That’s great!’ said the woman, ‘How did your chickens become fertile?’ ‘I used a different cock,’ he replied. The woman smiled, clinked his glass and said ‘what a coincidence’! +
+ submitted by /u/LunaTic2009
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+so he could fit the rest of the socks in her drawer.” +
+ submitted by /u/DrEvilsClone
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+The dad says, "Well son, let me try to explain it this way: +
++I’m the breadwinner of the family, so let’s call me capitalism. +
++Your mother, she’s the administrator of the money, so we’ll call her the government. +
++We’re here to take care of your needs, so we’ll call you the people. +
++The nanny, we’ll consider her the working class. +
++And your baby brother, we’ll call him the future. +
++Now, think about that and see if that makes sense." +
++The little boy goes off to bed thinking about what dad had said. Later that night, he hears his baby brother crying, so he gets up to check on him. He finds that the baby has soiled his diaper. The little boy goes to his parents’ room and finds his mother sound asleep. Not wanting to wake her, he goes to the nanny’s room. Finding the door locked, he peeks in the keyhole and sees his father in bed with the nanny. He gives up and goes back to bed. +
++The next morning, the little boy says to his father, “Dad, I think I understand the concept of politics now.” The father says, “Good son, tell me in your own words what you think politics is all about.” The little boy replies, “Well, while capitalism is screwing the working class, the government is sound asleep, the people are being ignored and the future is in deep shit.” +
+ submitted by /u/Odd-Specialist9012
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