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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Fc-gamma receptor-dependent antibody effector functions are required for vaccine protection against infection by antigenic variants of SARS-CoV-2</strong> -
<div>
Emerging SARS-CoV-2 variants with antigenic changes in the spike protein are neutralized less efficiently by serum antibodies elicited by legacy vaccines against the ancestral Wuhan-1 virus. Nonetheless, these vaccines, including mRNA-1273 and BNT162b2, retained their ability to protect against severe disease and death, suggesting that other aspects of immunity control infection in the lung. Although vaccine-elicited antibodies can bind Fc gamma receptors and mediate effector functions against SARS-CoV-2 variants, and this property correlates with improved clinical COVID-19 outcome, a causal relationship between Fc effector functions and vaccine-mediated protection against infection has not been established. Here, using passive and active immunization approaches in wild-type and Fc-gamma receptor (FcgR) KO mice, we determined the requirement for Fc effector functions to protect against SARS-CoV-2 infection. The antiviral activity of passively transferred immune serum was lost against multiple SARS-CoV-2 strains in mice lacking expression of activating FcgRs, especially murine FcgR III (CD16), or depleted of alveolar macrophages. After immunization with the preclinical mRNA-1273 vaccine, protection against Omicron BA.5 infection in the respiratory tract also was lost in mice lacking FcgR III. Our passive and active immunization studies in mice suggest that Fc-FcgR engagement and alveolar macrophages are required for vaccine-induced antibody-mediated protection against infection by antigenically changed SARS-CoV-2 variants, including Omicron strains.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.27.518117v1" target="_blank">Fc-gamma receptor-dependent antibody effector functions are required for vaccine protection against infection by antigenic variants of SARS-CoV-2</a>
</div></li>
<li><strong>Access to Opioid Agonist Treatment during COVID-19 Public Transport Disruptions</strong> -
<div>
Public transport disruptions caused by the COVID-19 pandemic had wide-ranging impacts on the ability of individuals to access health care. Individuals with opioid use disorder represent an especially vulnerable population due to the necessity of frequent, supervised doses of opioid agonists. Focused on Toronto, a major Canadian city suffering from the opioid epidemic, this analysis uses novel realistic routing methodologies to quantify how travel times to individuals’ nearest clinics changed due to public transport disruptions from 2019 to 2020. This analysis uses entirely open-source data sources to estimate the vulnerable populations that were impacted by the largest transport disruptions in the city’s history. Individuals seeking opioid agonist treatment face very constrained windows of access due to the need to manage work and other essential activities. As even small changes to travel times can lead to missed appointments and heighten the chances of overdose and death, understanding the distribution of those most impacted can help inform future policy measures to ensure adequate access to care.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/yvsn8/" target="_blank">Access to Opioid Agonist Treatment during COVID-19 Public Transport Disruptions</a>
</div></li>
<li><strong>Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination</strong> -
<div>
Two group 2B beta-coronaviruses (sarbecoviruses) have caused regional and global epidemics in modern history. The mechanisms of cross protection driven by the sarbecovirus spike, a dominant immunogen, are less clear yet critically important for pan-sarbecovirus vaccine development. We evaluated the mechanisms of cross-sarbecovirus protective immunity using a panel of alphavirus-vectored vaccines covering bat to human strains. While vaccination did not prevent virus replication, it protected against lethal heterologous disease outcomes in both SARS-CoV-2 and clade 2 bat sarbecovirus HKU3-SRBD challenge models. The spike vaccines tested primarily elicited a highly S1-specific homologous neutralizing antibody response with no detectable cross-virus neutralization. We found non-neutralizing antibody functions that mediated cross protection in wild-type mice were mechanistically linked to FcgR4 and spike S2-binding antibodies. Protection was lost in FcR knockout mice, further supporting a model for non-neutralizing, protective antibodies. These data highlight the importance of FcR-mediated cross-protective immune responses in universal pan-sarbecovirus vaccine designs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.28.518175v1" target="_blank">Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination</a>
</div></li>
<li><strong>SARS-CoV-2 Omicron subvariants Spike recognition and neutralization elicited after the third dose of mRNA vaccine</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Several SARS-CoV-2 Omicron subvariants have recently emerged, becoming the dominant circulating strains in many countries. These variants contain a large number of mutations in their Spike glycoprotein, raising concerns about vaccine efficacy. In this study, we evaluate the ability of plasma from a cohort of individuals that received three doses of mRNA vaccine to recognize and neutralize these Omicron subvariant Spikes. We observed that BA.4/5 and BQ.1.1 Spikes are markedly less recognized and neutralized compared to the D614G and the other Omicron subvariant Spikes tested. Also, individuals who have been infected before or after vaccination present better humoral responses than SARS-CoV-2 naive vaccinated individuals, thus indicating that hybrid immunity generates better humoral responses against these subvariants.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.08.03.22278386v2" target="_blank">SARS-CoV-2 Omicron subvariants Spike recognition and neutralization elicited after the third dose of mRNA vaccine</a>
</div></li>
<li><strong>The Shift of Percent Excess Mortality during the COVID-19 pandemic (2020-2022) in Singapore, South Korea, Australia, New Zealand and Hong Kong SAR</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Introduction: With the economic recession and pandemic fatigue, milder viral variants and higher vaccine coverage along the time lay the basis for lifting anti-COVID policies to restore COVID-19 normalcy. However, when and how to adjust the anti-COVID policies remain under debate in many countries. Methods: In this study, four countries (Singapore, South Korea, Australia, and New Zealand) and one region (Hong Kong SAR), that have shifted from the zero-COVID (ZC) policy to or close to the living-with-COVID (LWC) during or after the Omicron outbreak, were selected as research objects. All-cause mortality data were collected for these objects from 2009-2019. The expected mortality was estimated by a simple linear regression method. Excess mortality over time was calculated as the difference between the expected mortality and the observed mortality. Finally, percent excess mortality (PEM) was calculated as the excess mortality divided by the expected mortality. Results: In the examined four countries, PEM fluctuated around 0% and was lower than 10% most of the time under the ZC policy before 2022. After shifting to the LWC policy, all the examined countries increased the PEM. Briefly, countries with high population density (Singapore and South Korea) experienced an average PEM of 20-40% during the first half of 2022, and followed by a lower average PEM of 15-18% during the second half of 2022. For countries with low population density under the LWC policy, Australia experienced an average PEM of 39.85% during the first half of 2022, while New Zealand was the only country in our analysis that achieved no more than 10% in average PEM all the time. On the contrary, Hong Kong SAR under their ZC policy attained an average PEM of 71.14% during the first half of 2022, while its average PEM decreased to 9.19% in the second half of 2022 with LWC-like policy. Conclusion: PEM under different policies within each country/region overtime demonstrated that the mortality burden caused by COVID-19 had been reduced overtime. Moreover, anti-COVID policies are suggested to control the excess mortality to achieve as low as 10% in PEM.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.08.31.22279422v2" target="_blank">The Shift of Percent Excess Mortality during the COVID-19 pandemic (2020-2022) in Singapore, South Korea, Australia, New Zealand and Hong Kong SAR</a>
</div></li>
<li><strong>Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus</strong> -
<div>
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has claimed millions of lives worldwide, not to mention innumerable losses in the global economy and disruptions in social relationships. Unfortunately, state-of-the-art treatments still lag behind the fast emergence of new variants of concern. The key to resolve this issue is to develop broad-spectrum antivirals with innovative antiviral mechanisms in which coronaviruses are deactivated regardless of their variant development. Herein, we report a new antiviral strategy involving extracellular disintegration of viral proteins that are indispensable for viral infection with hyperanion-grafted enediyne molecules. The sulfate groups ensure low cellular permeability and rather low cytotoxicity of the molecules, while the core enediyne generates reactive radical species and causes significant damage to the spike (S) protein of coronavirus. The enediyne compounds exhibit antiviral activity at micromolar to nanomolar concentrations, and the selectivity index of up to 20,000 against four kinds of human coronaviruses, including the SARS-CoV-2 omicron variant, suggesting the high potential of this new strategy in combating the COVID-19 pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.24.517008v1" target="_blank">Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus</a>
</div></li>
<li><strong>SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects</strong> -
<div>
Experimental findings for SARS-CoV-2 related to the glycan biochemistry of coronaviruses indicate that attachments from spike protein to glycoconjugates on the surfaces of red blood cells (RBCs), other blood cells and endothelial cells are key to the infectivity and morbidity of COVID-19. To provide further insight into these glycan attachments and their potential clinical relevance, the classic hemagglutination (HA) assay was applied using spike protein from the Wuhan, Alpha, Delta and Omicron B.1.1.529 lineages of SARS-CoV-2 mixed with human RBCs. The electrostatic potential of the central region of spike protein from these four lineages was studied through molecular modeling simulations. Inhibition of spike protein-induced HA was tested using the macrocyclic lactone ivermectin (IVM), which is indicated to bind strongly to SARS-CoV-2 spike protein glycan sites. The results of these experiments were, first, that spike protein from these four lineages of SARS-CoV-2 induced HA. Omicron induced HA at a significantly lower threshold concentration of spike protein than for the three prior lineages and was much more electropositive on its central spike protein region. IVM blocked HA when added to RBCs prior to spike protein and reversed HA when added afterwards. These results validate and extend prior findings on the role of glycan bindings of viral spike protein in COVID-19. They furthermore suggest therapeutic options using competitive glycan-binding agents such as IVM and may help elucidate rare serious adverse effects (AEs) associated with COVID-19 mRNA vaccines which use spike protein as the generated antigen.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.24.517882v1" target="_blank">SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects</a>
</div></li>
<li><strong>Do Public Health Efforts Matter? Explaining Cross-Country Heterogeneity in Excess Death During the COVID-19 Pandemic</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The COVID-19 pandemic has taken a devastating toll around the world. Since January 2020, the World Health Organization estimates 14.9 million excess deaths have occurred globally. Despite this grim number quantifying the deadly impact, the underlying factors contributing to COVID-19 deaths at the population level remain unclear. Prior studies indicate that demographic factors like proportion of population older than 65 and population health explain the cross-country difference in COVID-19 deaths. However, there has not been a holistic analysis including variables describing government policies and COVID-19 vaccination rate. Furthermore, prior studies focus on COVID-19 death rather than excess death to assess the impact of the pandemic. Through a robust statistical modeling framework, we analyze 80 countries and show that actionable public health efforts beyond just the factors intrinsic to each country are necessary to explain the cross-country heterogeneity in excess death.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.21.22282563v2" target="_blank">Do Public Health Efforts Matter? Explaining Cross-Country Heterogeneity in Excess Death During the COVID-19 Pandemic</a>
</div></li>
<li><strong>Highly potent antisense oligonucleotides (ASOs) targeting the SARS-CoV-2 RNA genome</strong> -
<div>
Currently the world is dealing with the third outbreak of the human-infecting coronavirus with potential lethal outcome, cause by a member of the Nidovirus family, the SARS-CoV-2. The severe acute respiratory syndrome coronavirus (SARS-CoV-2) has caused the last worldwide pandemic. Successful development of vaccines highly contributed to reduce the severeness of the COVID-19 disease. To establish a control over the current and newly emerging coronaviruses of epidemic concern requires development of substances able to cure severely infected individuals and to prevent virus transmission. Here we present a therapeutic strategy targeting the SARS-CoV-2 RNA using antisense oligonucleotides (ASOs) and identify locked nucleic acid gapmers (LNA gapmers) potent to reduce by up to 96% the intracellular viral load in vitro. Our results strongly suggest promise of our preselected ASOs for further development as therapeutic or prophylactic anti-viral agents.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.28.518195v1" target="_blank">Highly potent antisense oligonucleotides (ASOs) targeting the SARS-CoV-2 RNA genome</a>
</div></li>
<li><strong>Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants</strong> -
<div>
The SARS-CoV-2 Omicron variant continues to evolve, with new BQ and XBB subvariants now rapidly expanding in Europe/US and Asia, respectively. As these new subvariants have additional spike mutations, they may possess altered antibody evasion properties. Here, we report that neutralization of BQ.1, BQ.1.1, XBB, and XBB.1 by sera from vaccinees and infected persons was markedly impaired, including sera from individuals who were boosted with a WA1/BA.5 bivalent mRNA vaccine. Compared to the ancestral strain D614G, serum neutralizing titers against BQ and XBB subvariants were lower by 13-81-fold and 66-155-fold, respectively, far beyond what had been observed to date. A panel of monoclonal antibodies capable of neutralizing the original Omicron variant, including those with Emergency Use Authorization, were largely inactive against these new subvariants. The spike mutations that conferred antibody resistance were individually studied and structurally explained. Finally, the ACE2-binding affinities of the spike proteins of these novel subvariants were found to be similar to those of their predecessors. Taken together, our findings indicate that BQ and XBB subvariants present serious threats to the efficacy of current COVID-19 vaccines, render inactive all authorized monoclonal antibodies, and may have gained dominance in the population because of their advantage in evading antibodies.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.23.517532v1" target="_blank">Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants</a>
</div></li>
<li><strong>Plasma after both SARS-CoV-2 boosted vaccination and COVID-19 potently neutralizes BQ1.1 and XBB.</strong> -
<div>
Background: The SARS-CoV-2 Omicron variants, dominating in the late 2022 COVID-19 waves, have acquired resistance to most neutralizing anti-Spike monoclonal antibodies authorized so far, and the BQ.1.* sublineages, dominant in the western countries, are notably resistant to all authorized monoclonal antibodies. Polyclonal antibodies from individuals both with at least 3 vaccine doses and also recently recovered from Omicron COVID-19 (VaxCCP) could retain neutralizing activity against such new Omicron lineages. Methods: Here we reviewed BQ.1.1 virus neutralization data from 652 individual patient samples from 32 separate cohorts defined by boosted vaccinations with or without recent Omicron COVID-19, as well as infection without vaccination. Findings: More than 97% of the plasma samples from individuals in the recently (within 6 months) boosted VaxCCP study cohorts neutralized BQ.1.1, XBB and BF.7 with 100% neutralization of WA-1, BA.4/5, BA.4.6 and BA.2.75. The geometric mean of the geometric mean 50% neutralizing titers (GMT(GMT50) were 201, 52 and 204 for BQ.1.1, XBB and BF.7, respectively. Compared to VaxCCP, plasma sampled from COVID-19 naive subjects who also recently within 6 months received at least a third vaccine dose had about half of the GMT(GMT50) for all viral variants with percent neutralizations of 82%, 60% and 94% for BQ.1.1, XBB and BF.7, respectively. Interpretation: Boosted VaxCCP characterized by either recent vaccine dose or infection event within 6 months represents a robust, variant-resilient, passive immunotherapy against the new Omicron BQ.1.1, XBB and BF.7 variants. Funding: Department of Defense in collaboration with the Defense Health Agency, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.25.517977v1" target="_blank">Plasma after both SARS-CoV-2 boosted vaccination and COVID-19 potently neutralizes BQ1.1 and XBB.</a>
</div></li>
<li><strong>Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2</strong> -
<div>
Emergence of SARS-CoV-2 variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral evolution is therefore necessary. Using coldspot-guided antibody discovery, a screening approach that focuses on portions of the virus spike that are both functionally relevant and averse to change, we identified human neutralizing antibodies to highly conserved viral epitopes. Antibody fp.006 binds the fusion peptide and cross-reacts against coronaviruses of the four genera, including the nine human coronaviruses, through recognition of a conserved motif that includes the S2’ site of proteolytic cleavage. Antibody hr2.016 targets the stem helix and neutralizes SARS-CoV-2 variants. Antibody sd1.040 binds to subdomain 1, synergizes with antibody rbd.042 for neutralization and, like fp.006 and hr2.016, protects mice when present as bispecific antibody. Thus, coldspot-guided antibody discovery reveals donor-derived neutralizing antibodies that are cross-reactive with Orthocoronavirinae, including SARS-CoV-2 variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.24.515932v1" target="_blank">Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2</a>
</div></li>
<li><strong>Long-term immune protection against SARS-CoV-2 escape variants upon a single vaccination with murine cytomegalovirus expressing the spike protein</strong> -
<div>
Vaccines are central to controlling the coronavirus disease 2019 (COVID-19) pandemic but the durability of protection is limited for currently approved COVID-19 vaccines. Further, the emergence of variants of concern (VoCs) that evade immune recognition has reduced vaccine effectiveness, compounding the problem. Here, we show that a single dose of a murine cytomegalovirus (MCMV)-based vaccine, which expresses the spike (S) protein of the virus circulating early in the pandemic (MCMVS), protects highly susceptible K18-hACE2 mice from clinical symptoms and death upon challenge with a lethal dose of D614G SARS-CoV-2. Moreover, MCMVS vaccination controlled two immune-evading VoCs, the Beta (B.1.135) and the Omicron (BA.1) variants in BALB/c mice, and S-specific immunity was maintained for at least 5 months after immunization, where neutralizing titers against all tested VoCs were higher at 5-months than at 1-month post-vaccination. Thus, cytomegalovirus (CMV)-based vector vaccines might allow for long-term protection against COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.25.517953v1" target="_blank">Long-term immune protection against SARS-CoV-2 escape variants upon a single vaccination with murine cytomegalovirus expressing the spike protein</a>
</div></li>
<li><strong>Identifying functionally distinctive and threatened species</strong> -
<div>
Functional traits determine species’ responses to environmental change and/or determine species’ effects on ecosystem functions. When species with distinctive functional traits are threatened, there is a risk that ecosystem properties are also threatened. This is because functionally distinctive species may be those that have irreplaceable roles in an ecosystem and/or those that would be able to survive unusual environmental disturbances. To include functional distinctiveness as a criterion in conservation strategies, we need formal quantification of the degree of distinctiveness and threat a species exhibits. Starting with previous quantification attempts, we develop a framework that links different viewpoints on functional distinctiveness and accounts for all species’ extinction probabilities. Our framework is particularly relevant at the local scale where species extinctions impact ecosystem functioning and where conservation policies are developed. As a case study, we thus applied our framework to the mammals of Indian dry forests known to be threatened with a drastic decrease in functional diversity. We notably highlight that although some of the functionally distinctive and threatened species we identified, such as the tiger, are charismatic and considered by conservation actions, others are not. This is the case for some rat species and pangolins, whose negative image in the media during the COVID-19 pandemic could be detrimental to attracting public interest in their preservation. From this case study, we note that noncharismatic, less known species that may be key for ecosystems could be revealed by applying our framework to a range of ecosystems and taxa.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.11.28.518165v1" target="_blank">Identifying functionally distinctive and threatened species</a>
</div></li>
<li><strong>Strengthening response coordination through public health emergency operations centers in Africa: Lessons learned from 56-week webinar sessions, 2020-2021</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background Following the declaration of coronavirus disease 2019 (COVID-19) as a pandemic on 11 March 2020, in-person events including trainings were canceled to limit the spread of the pandemic. A virtual learning program was established in May 2020 by Africa Centers for Disease Control and Prevention, the World Health Organization, and other partners to strengthen COVID-19 response coordination through the public health emergency operations centers (PHEOCs). We present a review of the webinar series, the experience, and the lessons learned. Method A data extraction tool was developed to retrieve data from the Africa CDC9s webinar data repository. Major findings were synthesized and described per thematic area. Results A total of 12,715 (13% of the 95,230 registrants) attended the 56 PHEOC webinar sessions between June 2020 and December 2021 and 47% of the attendees came from 17 countries. Of those who attended, 8,528 (70%) were from Africa. The webinars provided 97 learning hours with an average length of 1.18 hours per session. On average, there were 235 attendees per session. In addition, there was an average of 26 interactions between participants and facilitators per session. A total of 4,084 (44%) of the participants (9,283) responded to the post-session surveys, with over 95% rating the webinar topics as being relevant to their work, contributed to improving their understanding of PHEOC operationalization, and with extensive ease of comprehension. Conclusion The virtual training served the intended audience given the high number of participants from African member states, with satisfactory feedback on training relevance. We highlighted a just-in-time, progressively adaptive experience in delivering a PHEOC/PHEM virtual learning in Africa with a consequential global audience at the peak of the COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.22.22282627v1" target="_blank">Strengthening response coordination through public health emergency operations centers in Africa: Lessons learned from 56-week webinar sessions, 2020-2021</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate EDP-235 in Non-hospitalized Adults With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: EDP-235;   Drug: Placebo<br/><b>Sponsor</b>:   Enanta Pharmaceuticals, Inc<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of RAY1216 Tablets Compared With Placebo in Patients With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   Mild to Moderate COVID-19<br/><b>Interventions</b>:   Drug: RAY1216;   Drug: Placebo<br/><b>Sponsor</b>:   Guangdong Raynovent Biotech Co., Ltd<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Acute Rehabilitation in Patients With COVID-19 Pneumonia</strong> - <b>Conditions</b>:   COVID-19;   Rehabilitation;   Physical Medicine<br/><b>Intervention</b>:   Procedure: Acute rehabilitation program<br/><b>Sponsor</b>:   Institut za Rehabilitaciju Sokobanjska Beograd<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Trial Evaluate the Immunogenicity and Safety of Recombinant COVID-19 Omicron-Delta Variant Vaccine (CHO Cell)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Omicron-Delta Recombinant Novel Coronavirus Protein Vaccine (CHO cells);   Biological: Recombinant Novel Coronavirus Protein Vaccine (CHO cells)<br/><b>Sponsor</b>:   Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Message Communicating Latest Data on COVID Transmission in Patient’s Area</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Behavioral: COVID Booster text messages<br/><b>Sponsor</b>:   University of Pennsylvania<br/><b>Enrolling by invitation</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dietary Modulation of Gut Microbiota in Overweight/Obese Adolescents and COVID-19 Infection</strong> - <b>Conditions</b>:   Health Behavior;   Child Development;   Adolescent Obesity<br/><b>Interventions</b>:   Dietary Supplement: Probiotics;   Behavioral: Counselling on healthy eating, physical activity, and psychosocial stimulation;   Dietary Supplement: Placebo probiotics<br/><b>Sponsors</b>:   Indonesia University;   Gadjah Mada University;   Universitas Airlangga;   University of Melbourne;   The Indonesia Endowment Funds for Education, Ministry of Finance Indonesia<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phonation Therapy to Improve Symptoms and Lung Physiology in Patients Referred for Pulmonary Rehabilitation</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Tonation Breathing Techniques;   Behavioral: Music Driven Vocal Exercises;   Behavioral: Silent Breathing<br/><b>Sponsor</b>:   MetroHealth Medical Center<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Long COVID-19 Intervention Using Digital Health &amp; Technology</strong> - <b>Conditions</b>:   Long COVID;   Distress Tolerance<br/><b>Intervention</b>:   Behavioral: iENDURE<br/><b>Sponsors</b>:   Rhode Island Hospital;   Brown University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Xylitol Based Nasal Spray for COVID-19 Treatment</strong> - <b>Condition</b>:   Respiratory Viral Infection<br/><b>Intervention</b>:   Device: Nasal Spray<br/><b>Sponsors</b>:   Xlear, Inc;   Metanoic Health Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Myocardial Protection in Patients With Post-acute Inflammatory Cardiac Involvement Due to COVID-19</strong> - <b>Conditions</b>:   Myocardial Inflammation;   Remodeling, Left Ventricle;   Remodeling, Vascular;   Left Ventricular Dysfunction;   Exercise Intolerance<br/><b>Interventions</b>:   Drug: Prednisolone;   Drug: Losartan<br/><b>Sponsors</b>:   Valentina Puentmann;   Bayer;   Alcedis GmbH<br/><b>Enrolling by invitation</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Brief Cognitive Task Intervention for NHS Staff Affected by COVID-19 Trauma (GAINS-2 Study)</strong> - <b>Condition</b>:   Intrusive Memories of Traumatic Event(s)<br/><b>Interventions</b>:   Behavioral: Brief imagery-competing task;   Behavioral: Brief music-listening task;   Other: Treatment As Usual<br/><b>Sponsors</b>:   P1vital Products Limited;   Wellcome Trust (Funder);   Uppsala University (Department of Psychology);   Intensive Care Society (Communication Department);   University of Oxford (Department of Biology);   University of Nottingham (Institute of Mental Health)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate Pharmacokinetics, Safety &amp; Tolerability of 101-PGC-005 in Healthy, Adult, Human Subjects</strong> - <b>Conditions</b>:   Glucocorticoids Toxicity;   COVID-19;   Infectious Disease;   Virus Diseases<br/><b>Intervention</b>:   Drug: 101-PGC-005<br/><b>Sponsor</b>:   101 Therapeutics<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen</strong> - <b>Condition</b>:   Acute Respiratory Failure<br/><b>Interventions</b>:   Drug: Tozorakimab;   Drug: Placebo<br/><b>Sponsor</b>:   AstraZeneca<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms</strong> - In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the pathophysiological mechanisms and related therapeutic methods remain obscure. Considering the increased concerns of SARS-CoV-2 potential for more serious neuroinvasion conditions, the present review attempts to focus on the neuroprotective effects of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Onychomadesis in a COVID-19 patient</strong> - We report the case of a 67-year-old woman who developed onychomadesis on 9 of her fingers 2 months after recovering from COVID-19, with subsequent full nail regrowth after 4 months. The development of onychomadesis in COVID-19 is probably related to inhibition of nail proliferation due to fever, direct viral damage, or an inflammatory process associated with endothelial damage and obliterative microangiopathy in the nail matrix area. Clinicians should be aware of nail changes and actively seek…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An evaluation of the convergent validity of a face-to-face and virtual neuropsychological assessment counter balanced</strong> - The COVID-19 pandemic has highlighted the need for further research evaluating the validity of conducting a battery of neuropsychological assessments virtually compared with face-to-face administration. Previous research has suggested that some neuropsychological assessments yield valid results when administered virtually, however, much of the previous research focused on older adults. To determine the validity of virtually administered neuropsychological tests, 28 healthy participants were…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nintedanib: a review of the properties, function, and usefulness to minimize COVID-19 induced lung injury</strong> - INTRODUCTION: In severe COVID-19 patients, acute respiratory distress syndrome (ARDS)-induced lung injury regularly causes a pulmonary fibrotic phase. There is no approved therapy for the COVID-19-induced pulmonary fibrosis. However, administration of an anti-fibrotic agent, in the early acute phase of the severe COVID-19 with ARDS may improve the infection outcomes.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reactive-diffusion epidemic model on human mobility networks: Analysis and applications to COVID-19 in China</strong> - The complex dynamics of human mobility, combined with sporadic cases of local outbreaks, make assessing the impact of large-scale social distancing on COVID-19 propagation in China a challenge. In this paper, with the travel big dataset supported by Baidu migration platform, we develop a reactive-diffusion epidemic model on human mobility networks to characterize the spatio-temporal propagation of COVID-19, and a novel time-dependent function is incorporated into the model to describe the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Home Sweet Home: Working from home and employee performance during the COVID-19 pandemic in the UK</strong> - In 2020, many governments responded to the COVID-19 pandemic by encouraging employees to work from home (WFH). Analyzing representative data from the UK, we find that the pandemic-led increases in WFH frequency are associated with a higher self-perceived hourly productivity among employed respondents. Interestingly, changes in WFH frequency are unrelated to the respondents’ weekly working hours and weekly wages during the same period. While the WFH-productivity association is more substantial in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fusion assays for screening of fusion inhibitors targeting SARS-CoV-2 entry and syncytia formation</strong> - Virus fusion process is evolutionarily conserved and provides a promising pan-viral target. Cell-cell fusion leads to syncytial formation and has implications in pathogenesis, virus spread and immune evasion. Drugs that target these processes can be developed into anti-virals. Here, we have developed sensitive, rapid, adaptable fusion reporter gene assays as models for plasma membrane and alternative fusion pathways as well as syncytial fusion in the severe acute respiratory syndrome coronavirus…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Review of preclinical data of PF-07304814 and its active metabolite derivatives against SARS-CoV-2 infection</strong> - Main protease (M^(pro)) is a superior target for anti-SARS-COV-2 drugs. PF-07304814 is a phosphate ester prodrug of PF-00835231 that is rapidly metabolized into the active metabolite PF-00835231 by alkaline phosphatase (ALP) and then suppresses SARS-CoV-2 replication by inhibiting M^(pro). PF-07304814 increased the bioavailability of PF-00835231 by enhancing plasma protein binding (PPB). P-glycoprotein (P-gp) inhibitors and cytochrome P450 3A (CYP3A) inhibitors increased the efficacy of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>mRNA-based vaccine technology for HIV</strong> - Human immunodeficiency virus (HIV) poses a major health problem around the globe, resulting in hundred-thousands of deaths from AIDS and over a million new infections annually. Although the standard treatment of HIV infection, antiretroviral therapy, has proven effective in preventing HIV transmission, it is unsuitable for worldwide use due to its substantial costs and frequent adverse effects. Besides promoting HIV/AIDS awareness through education, there is hardly an alternative for inhibiting…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Does ambient air quality standard contribute to green innovation of enterprises in China? Implications for environmental protection and public health</strong> - In the post-COVID-19 era, environmental pollution has been a serious threat to public health. Enterprises are in urgent need of enhancing green technology innovation as the main source of pollutant emissions, and it is necessary for governments to support green innovation of enterprises to reduce pollutant emissions and promote public health. In this context, this paper investigates whether the Ambient Air Quality Standard (AAQS) implemented in 2012 in China contributes to green innovation of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong><em>In vitro</em> evaluation of the activity of teriflunomide against SARS-CoV-2 and the human coronaviruses 229E and OC43</strong> - Previous data have suggested an antiviral effect of teriflunomide, including against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the agent underlying the ongoing COVID-19 pandemic. We undertook an in vitro investigation to evaluate the inhibitory activity of teriflunomide against SARS-CoV-2 in a cell-based assay. Teriflunomide was added to Vero (kidney epithelial) cells that had been infected with SARS-CoV-2. A nucleocapsid immunofluorescence assay was performed to examine…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational screening of natural products to identify potential inhibitors for human neuropilin-1 (NRP1) receptor to abrogate the binding of SARS-CoV-2 and host cell</strong> - Recently, a new variant B.1.1.529 or Omicron variant and its sub-variants (BA2.75, BA.5) of SARS-CoV-2 (Severe acute respiratory virus 2) have been reported with a larger number of mutations in the spike protein and particularly in the RBD (receptor-binding domain). The omicron (B.1.1.529) variant has aggravated the pandemic situation further and needs more analysis for therapeutic development. Keeping in view the urgency of the required data, the current study used molecular modeling and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Integrative transcriptome analysis of SARS-CoV-2 human-infected cells combined with deep learning algorithms identifies two potential cellular targets for the treatment of coronavirus disease</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread worldwide, leading coronavirus disease 2019 (COVID-19) to hit pandemic level less than 4 months after the first official cases. Hence, the search for drugs and vaccines that could prevent or treat infections by SARS-CoV-2 began, intending to reduce a possible collapse of health systems. After 2 years, efforts to find therapies to treat COVID-19 continue. However, there is still much to be understood about the virus’…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Single-cell RNA-sequencing data analysis reveals a highly correlated triphasic transcriptional response to SARS-CoV-2 infection</strong> - Single-cell RNA sequencing (scRNA-seq) is currently one of the most powerful techniques available to study the transcriptional response of thousands of cells to an external perturbation. Here, we perform a pseudotime analysis of SARS-CoV-2 infection using publicly available scRNA-seq data from human bronchial epithelial cells and colon and ileum organoids. Our results reveal that, for most genes, the transcriptional response to SARS-CoV-2 infection follows a non-linear pattern characterized by…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors</strong> - Ferroptosis induced by detrimental accumulation of lipid peroxides has been recently linked to a variety of pathological conditions ranging from acute tissue injuries to chronic degenerative diseases and suppression of ferroptosis by small chemical inhibitors is beneficial to the prevention and treatment of these diseases. However, in vivo applicable small chemical ferroptosis inhibitors are limited currently. In this study, we screened an alkaloid natural compound library for compounds that can…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Is the Nancy Pelosi Era Really Ending?</strong> - The Speaker of the House is stepping aside, but her school of politics isn’t going anywhere. - <a href="https://www.newyorker.com/magazine/2022/12/05/is-the-nancy-pelosi-era-really-ending">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Are We Doomed to See a Biden-Trump Rematch in 2024?</strong> - One thing’s sure: the early betting is often wrong—ask President Rand Paul. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/are-we-doomed-to-see-a-biden-trump-rematch-in-2024">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sam Bankman-Fried and the Long Road to Taking Crypto Mainstream</strong> - The disgraced founder of FTX played on the vanities of the establishment, reassuring V.C. firms and the media that smart-guy insiders like him could save the world. - <a href="https://www.newyorker.com/news/our-columnists/sam-bankman-fried-and-the-long-road-to-taking-crypto-mainstream">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What’s at Stake in the University of California Graduate-Worker Strike</strong> - The seventy per cent of Americans who support unions should understand that the future of organized labor won’t be in coal mines or steel mills, but in places that might cut against the stereotypes. - <a href="https://www.newyorker.com/news/our-columnists/whats-at-stake-in-the-university-of-california-graduate-worker-strike">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chinese Protesters Warily Tell Xi Jinping, “Don’t Push Me”</strong> - The nation’s most defiant public demonstrations in years oppose “zero COVID” policies, but their roots run deeper. - <a href="https://www.newyorker.com/news/daily-comment/chinese-protesters-warily-tell-xi-jinping-dont-push-me">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Maxwell Frost on why he isn’t worried about being the first Gen Z member in Congress</strong> -
<figure>
<img alt="US Representative-elect Maxwell Frost, Democrat of Florida, arrives for a group photo with other new members outside of the US Capitol in Washington, DC on November 15, 2022.&amp;nbsp;" src="https://cdn.vox-cdn.com/thumbor/3rNTluIpGqEpxmu3MQeTviay0Ns=/958x0:6358x4050/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71686197/1244799160.0.jpg"/>
<figcaption>
US Representative-elect Maxwell Frost, Democrat of Florida, arrives for a group photo with other new members outside of the US Capitol in Washington, DC, on November 15.  | Mandel Ngan/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The representative-elect for Florida’s 10th Congressional District is used to being the youngest person in the room.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ewWeNg">
Florida is one state where a big <a href="https://www.vox.com/midterm-elections-2022/2022/11/11/23452549/midterm-elections-2022-results-florida-republicans-red-wave-swing-state">red wave</a> did hit in the 2022 midterms, producing a banner year for Republicans even where they fizzled elsewhere. But the election of <a href="https://www.vox.com/policy-and-politics/23448463/midterm-elections-results-2022-frost-gen-z-congress-healey-huckabee-sanders">Maxwell Alejandro Frost</a> to represent Florida’s 10th Congressional District provided Democrats some good news that could ripple for years to come: Frost, 25, will be the first Gen Z member of Congress.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DxxjKB">
Frost will be the youngest member of Congress, but he does have a decade of experience as an activist and organizer, and those experiences shaped his campaign’s platform. He is a former March for Our Lives organizer, he worked on prison reform in Florida, and he’s advocated for securing abortion rights, creating solutions to address climate change and for more accessible housing and transit. Now he has to translate that experience to the House of Representatives.
</p>
<aside id="S9pPSO">
<div>
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</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zHApCC">
“I’m going into a system that has caused a lot of harm historically,” Frost told <a href="https://www.vox.com/today-explained"><em>Today, Explained</em></a> host Noel King for a recent episode. “But I also think that to give up on government as a path toward the world we want is to almost give up on our greatest tool that we have as far as being able to make the change. … I think we have to use every tool in our toolbox.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oiyMpz">
King spoke with Rep.-elect Frost during his trip to DC for congressional orientation about how people have reacted to his historic win, why he thinks more organizers should actually run for political office, and how he is feeling about the GOP gains in his state. Their conversation is below, edited for length and clarity. There’s much more in the full podcast, so listen to<em> </em><a href="https://www.vox.com/today-explained"><em>Today, Explained</em></a> wherever you get podcasts, including <a href="https://podcasts.apple.com/us/podcast/today-explained/id1346207297">Apple Podcasts</a>, <a href="https://podcasts.google.com/feed/aHR0cHM6Ly9yc3MuYXJ0MTkuY29tL3RvZGF5LWV4cGxhaW5lZA==">Google Podcasts</a>, <a href="https://open.spotify.com/show/3pXx5SXzXwJxnf4A5pWN2A">Spotify</a>, and <a href="https://www.stitcher.com/podcast/vox/today-explained">Stitcher</a>.
</p>
<div id="f4sZBA">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="21s2kg">
</p>
<hr class="p-entry-hr" id="JsMxOf"/>
<h4 id="0klU03">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IOYPST">
So you’re the first member of Generation Z elected to Congress. How do you feel?
</p>
<h4 id="TMzVZX">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KXzFww">
I feel great. You know, it’s all the emotions at once. I feel incredibly blessed. We had hundreds of people who really came together to be a part of this movement and really make this win possible. And then also the pressures of just getting the office ready and just ensuring that we’re all good for January so [we] can really serve the people immediately.
</p>
<h4 id="Gsy7Zq">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zdnR7r">
You’re in Washington, DC, this week doing orientation. Yes?
</p>
<h4 id="CexPUz">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wrkJjk">
Yup.
</p>
<h4 id="WHZqWd">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L9J7OW">
What’s one thing about orientation that you think you’ll never forget? One experience.
</p>
<h4 id="UVctxU">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NVPMvQ">
I think the connections I’m making and just being able to make some really great friendships. On the Democratic side, it’s such a diverse and young class of people. People like [incoming Congress members] Greg Casar in Austin, Texas, or Delia Ramirez [of Illinois], Jasmine Crockett [of Texas], Summer Lee [of Pennsylvania] … it’s just really exciting to build these strong relationships.
</p>
<h4 id="Gbnvap">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AqBYEu">
After the midterms, I was talking to a man who spent many years on Capitol Hill many years ago. I asked him what he thought you might encounter. And he said, well, no one is going to believe that he’s in Congress. Referring to your age, of course. Have you experienced any of that? Anyone saying things like, “Son, what are you doing here?”
</p>
<h4 id="pSh6xH">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bw5LlS">
Not from members, but I’ve counted five times now that I’ve been stopped and told, “Oh, this is the members line,” or this and that. But it’s okay; I don’t really hold it against people too much. I mean, the fact of the matter is it is abnormal for a 25-year-old to be in the halls of Congress as a member. And so I’m one of many folks, hopefully, young folks that’ll change that stigma.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Yw6tGC">
I was walking into a building and was walking through the member line, which we’re allowed to do with our ID. And the guy was like, “Oh, hey, that’s for members, you got to come through here.” And it’s like, “Oh, I’m a member-elect,” [and] show my ID and he’s like, “Wait, let me see it.” And then he and the other guard looked at it, and they started cheering and they’re like, “Oh, my god, you’re so young! And he’s Black! Only in America!” They were like jumping up and down and clapping and it was actually really cool. It was really sweet. It was funny.
</p>
<h4 id="tim6YK">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="er2o31">
What did you feel like when you heard that?
</p>
<h4 id="NIXkHP">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CPj0gs">
I think that feeling that they had is really the feeling that hopefully a lot of people across the country have had. But, again, not just my election, but the election of just really great young people, especially young people of color coming in the freshman class.
</p>
<h4 id="ZNeWhT">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9LPkvm">
The average age in the House of Representatives is 59-ish. So you’re going to be very young compared to many of your colleagues. And I wonder, what do you think the challenges will be having colleagues who are, on the whole, just a lot older than you?
</p>
<h4 id="RtfyfR">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JjDwNZ">
The great thing is a lot of my colleagues are really just excited to have me there. Something that Speaker Pelosi told me just a few days after I won my primary is that it’s going to be really a breath of fresh air to have young people in the caucus.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SaYTdJ">
I think there’s often times where people won’t take me as seriously or look down on me, but that’s something I’m used to. I mean, I’ve been working full time in politics since straight out of high school at 18 years old, and I’ve always been the youngest person in the room. I’ve managed people twice my age … even though it’s at a whole new level now, the United States Congress, I’m ready for it.
</p>
<h4 id="wBhF1P">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NG92Th">
How did you get your start at 18?
</p>
<h4 id="82NLdS">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MOb8hp">
My start was actually at 15. 18 is really when it kind of became my career, but how I really got involved was 10 years ago was the Sandy Hook shooting. It had an insane impact on my life. I couldn’t think straight and I ended up going to the memorial in Washington, DC. It was there that I met a guy named Matthew Soto. Matthew’s sister Vicki was one of the teachers at Sandy Hook that lost her life. And seeing Matthew crying and talking about how much he missed a sister, seeing a 16-year-old with the demeanor of a 60-year-old, just completely changed my life forever. I went straight to my hotel room and I dedicated the rest of my life to fighting for a world where no one would have to feel the pain that I saw in Matthew’s eyes. And for me, that really is what changed everything for me.
</p>
<h4 id="gyIDUy">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LvQ3L1">
Organizing and being a politician, as you well know at this point, are two very different things. Why did you decide that you wanted to go into politics?
</p>
<h4 id="TYwUZ7">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LCY1mG">
I actually think organizing and legislating and being a member of Congress are a lot more similar than we think it is. The crux of what we do up here is work to pass legislation. You have to get buy-in from your colleagues, and you have to sometimes work with people across the aisle as well. Organizing is all about bringing people together around a common shared value for a specific outcome and asking them to take action. It could be knocking doors. It could be protesting. In this case, it’s casting a ballot and asking them to also help you inspire other people to be involved. So I think that’s part of the reason that we could use more organizers in Congress: Maybe we would get some more things done.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cQdWwZ">
Another big function of a member of Congress is to be a community leader, to build power in the community and to help shift the narrative and really use the bully pulpit to change the way people think about these issues. I think about Representative Cori Bush. When they took out the eviction moratorium [on renters in 2021], she knew what it was like to sleep on the streets, and <a href="https://www.cnn.com/2021/07/31/politics/cori-bush-eviction-moratorium-cnntv/index.html">she slept on the Capitol steps</a>. And because of her advocacy, it was extended, and people stayed in their homes.
</p>
<h4 id="new4X6">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JkqIAU">
The results of the 2022 midterms and the results of the past couple of years suggest that Florida is becoming a red state. It used to be a swing state. When you were young, it was one of the swingiest states. What do you think the Democratic Party is doing wrong? How is it losing Florida?
</p>
<h4 id="vebKaZ">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="86ByAL">
Sometimes, especially in Florida, these Democratic campaigns end up being campaigns of just rebutting Republicans. Right. The Republicans call you this name — you spend a million dollars on a commercial that says, “I’m not that.” Republicans say, you believe this. You spend a million dollars on commercials saying you didn’t do that. We spend so much time talking about what we’re not and don’t spend as much time talking about what we are and what we believe in. What I found in my organizing is people are more apt and excited to vote for you if they have something to believe in. … [Election night] was very bittersweet for me because I obviously had my win in my historic win, but we lost a lot of great people in our state legislature, so there’s still a lot of work to do in Florida.
</p>
<h4 id="MW1iOP">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f8ptIP">
When you were campaigning, you talked a lot about love, which was interesting. It’s not a word you hear all the time in political campaigns. And you talked about thinking beyond partisanship. Now, research has shown that a lot of millennials refused to run for office because of the perceived toxicity of Congress — the partisanship, the fights, the refusing to work across the aisle. You seem like a very optimistic man. How are you going to deal with gridlock and partisanship and just straight negativity?
</p>
<h4 id="GESxdL">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9MB1h8">
Yeah. I mean, and Congress is toxic.
</p>
<h4 id="SwHehd">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WPgQYL">
Oh, you agree? Okay.
</p>
<h4 id="rVnqoM">
Rep.-elect Frost
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QcfNJJ">
I mean, we know this, right? It’s something I’ve had to square. I’m going into a system that has caused a lot of harm historically. But I also think that to give up on government as a path toward the world we want is to almost give up on our greatest tool that we have. … I think we have to use every tool in our toolbox. We got to vote. We got to protest. We got to be involved in our arts and culture, because that changes the way that our society thinks about these issues. And we also got to engage in mutual aid so we can take care of each other.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zyt3QT">
I was just talking with a colleague about this a few [days] ago [while] we were at a dinner …partisanship is even built into the operation of Congress. There’s different cloakrooms. Republicans sit on one side. Democrats sit on the other side. At this orientation, we have different dinners every night that are separated. There really has not, as of yet, been bipartisan things that we’ve done besides the classes that we were sitting in. We’re not really talking to each other. We’re trying to pay attention to what’s being said. I think it really even subconsciously continues to sow in the divide that we have right now, which is unfortunate. Obviously, look, I’m really new here and I think there’s obviously traditions … but I can tell some of the reasons why there’s so much divide. Things are just divided, even in the operation of the way Congress works.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S7elWf">
The other thing I’ll say is part of the reason why these times are becoming even more divided is we have a far-right MAGA movement that is scapegoating every vulnerable community for every problem there is. It’s hard to come to the table with someone who doesn’t respect your humanity. Imagine being a queer legislator and coming into this body or being a trans legislator and coming to this body, having to sit across from someone and talk about issues [with someone] who doesn’t value your existence as a human. That’s something that we have to square and figure out.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r37hBl">
Bipartisanship is incredibly important — compromise is part of governing — but we also have to we also have to be very frank about the dangers looming in in government right now and this threat against our democracy, which is really this far-right movement that doesn’t want to work with other people, that wants to blame everybody else for all the problems that are going on and wants to look working-class people in the face and tell them that the source of their problem isn’t the people who are making the most money or the people who have traditionally had the most, but it’s their fellow neighbor who might look different than them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5lApic">
In this political work, we have to really pierce that and get straight to the humanity of people and just talk about the fact that we’re all part of this grand mosaic of humanity. You can eat and I can eat — you can succeed and I can succeed. In fact, our great successes are really tied together. [With] that message, I’ve seen it strike a chord with Republicans, with Democrats, with progressives, with moderates, with all different types of people in my district. That’s the message that I think is a winning one.
</p></li>
<li><strong>Why the global economy is slowing</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/ZX3Hf4iVMJBEod4ELCVMPq6kd7I=/0x0:3467x2600/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71686082/GettyImages_1245056914a.0.jpg"/>
<figcaption>
A pedestrian walks past a going-out-of-business sale in Birmingham, United Kingdom, on November 23. | Mike Kemp/In Pictures via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The war in Ukraine, rising interest rates, and lockdowns in China are all weighing on global growth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="16vGL3">
It’s not just the United States — the global economy is slowing down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LejdK3">
Inflation in European countries has spiked as the war in Ukraine has pushed up prices for essentials like heating, gas, and food. China’s “zero Covid” policies of strict lockdowns and mass testing continue to disrupt the production of goods. And around the world, central banks are raising interest rates in an attempt to bring rising prices under control by weakening consumer demand.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kUf9n4">
The International Monetary Fund has lowered its growth outlook for 2023, projecting that <a href="https://www.imf.org/en/Publications/WEO/Issues/2022/10/11/world-economic-outlook-october-2022">the world economy will grow 2.7 percent in 2023</a>, down from 3.2 percent this year. The IMF said in a report last month that the global economy was facing “steep challenges” as pandemic-related supply-chain disruptions, the war in Ukraine, China’s economic slowdown, and <a href="https://www.imf.org/en/Blogs/Articles/2022/08/01/blog-soaring-inflation-puts-central-banks-on-a-difficult-journey-080122#:~:text=The%20Federal%20Reserve%2C%20Bank%20of,in%20more%20than%20a%20decade.">rising interest rates</a> weigh on growth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zPcUMb">
“In short, the worst is yet to come, and for many people 2023 will feel like a recession,” the organization said in the report.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VJ70dC">
In the United States, recession fears have grown and inflation remains stubbornly high. Some economists and investors have voiced concerns about the Federal Reserve’s aggressive interest rate hikes and how much they could weaken the world’s biggest economy. By making borrowing money more expensive, the central bank is trying to slow consumer demand, which should lead to slower price growth. But that could also trigger an economic downturn if businesses significantly slow hiring or lay off workers in response.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NgorPn">
Still, some economists say the United States is actually in a better position than many other nations. European countries, for instance, are <a href="https://www.imf.org/en/Blogs/Articles/2022/10/23/europe-must-address-a-toxic-mix-of-high-inflation-and-flagging-growth">experiencing a dramatic slump</a> because their energy supplies have been hurt more by the war in Ukraine. Many American households still have excess pandemic savings, and unemployment in the United States remains low.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5HY8Tl">
“We’re raising interest rates fairly aggressively and financial market conditions have tightened in the US,” said Ryan Sweet, the chief US economist at Oxford Economics. “But so far, the economy’s weathered it reasonably well. Inflation is high in the US, but it’s high almost everywhere.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ju8225">
Central banks around the world have lifted interest rates to combat surging prices. The European Central Bank started raising rates earlier this year, and <a href="https://apnews.com/article/inflation-business-economy-prices-euro-e9c7d19463777769ed044e08dba4aecc">officials recently signaled that they aren’t yet done</a>. The <a href="https://www.bankofengland.co.uk/monetary-policy-summary-and-minutes/2022/november-2022#:~:text=The%20Bank%20of%20England's%20Monetary,percentage%20points%2C%20to%203%25.">Bank of England has also raised rates</a> multiple times this year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cM09kA">
There are several factors contributing to economic instability globally, ranging from the war in Ukraine to China’s strict Covid policies and weakening property industry.
</p>
<h3 id="Y2Styz">
The war in Ukraine
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ok5RVB">
The war in Ukraine has sparked an energy crisis in Europe, leading to a surge in prices. Countries that were more dependent on energy imports from Russia — such as <a href="https://www.oecd-ilibrary.org/sites/f6da2159-en/1/3/2/19/index.html?itemId=/content/publication/f6da2159-en&amp;_csp_=761d023775ff288a22ebcaaa183fbd6c&amp;itemIGO=oecd&amp;itemContentType=book">Germany</a> and Italy — have been <a href="https://www.piie.com/blogs/realtime-economics/high-inflation-makes-hard-road-ahead">hit especially hard by the restricted supply</a> of natural gas.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3zimnJ">
Inflation in the Eurozone <a href="https://ec.europa.eu/eurostat/documents/2995521/15265521/2-17112022-AP-EN.pdf/b6953137-786e-ed9c-5ee2-6812c0f8f07f#:~:text=The%20euro%20area%20annual%20inflation,%2C%20the%20rate%20was%204.4%25.">picked up 10.6 percent in October</a> from a year earlier, up from 9.9 percent the month before. Inflation in the United Kingdom has also surged because of skyrocketing energy bills. In October, <a href="https://www.ons.gov.uk/economy/inflationandpriceindices/bulletins/consumerpriceinflation/latest">consumer prices in Britain climbed 11.1 percent from a year before</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="prnvUk">
The war has also <a href="https://www.vox.com/policy-and-politics/2022/10/13/23402361/inflation-food-cpi-prices">disrupted exports of food</a> such as wheat, sunflower oil, and other produce, straining the global food supply and pushing up inflation further.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fnWGeZ">
These price increases could lead to a painful economic slowdown because things like food and gas tend to be necessary purchases for households. If European consumers are spending more of their budgets on those items, they have less money to spend on other goods and services, said Raghuram Rajan, a professor at the University of Chicago Booth School and a former chief economist at the IMF.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ojfxTD">
“Energy and food are an essential part of your household budget,” Rajan said. “The more you spend on essentials, the less you have on discretionary items, so you have to cut back on that spending.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G0nVXo">
Pierre Lafourcade, a global economist at UBS, said European households also haven’t acculumated as much excess savings as Americans. Earlier in the pandemic, American lawmakers passed more stimulus measures and sent direct checks to consumers, leading to more robust savings that have helped cushion household budgets.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gLFFXP">
“You didn’t have the equivalent in the Eurozone,” Lafourcade said. “In the Eurozone and in the UK, they never had excess savings to begin with.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aM8IAz">
UBS economists have predicted that the world economy will grow 2.1 percent next year, the lowest rate since 1993. Out of 32 economies, UBS expects 13 of them to contract for at least two quarters, which their economists say is akin to a global recession.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qr4XVd">
Although the war in Ukraine exacerbated global inflation, consumer prices were <a href="https://www.pewresearch.org/fact-tank/2022/06/15/in-the-u-s-and-around-the-world-inflation-is-high-and-getting-higher/">already on the rise around the world</a> before Russia’s invasion. Workers testing positive for Covid led to factory shutdowns and increased demand for goods among American consumers pushed up prices for many goods. The IMF projected that global inflation will rise to 8.8 percent in 2022 from 4.7 percent in 2021, although the agency expects overall price increases to fall to 6.5 percent in 2023.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5POKXw">
The main factors driving up inflation in the United States, however, have differed from countries in Europe.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BOqUL9">
Karen Dynan, an economics professor at Harvard University and a nonresident senior fellow at the Peterson Institute for International Economics, said inflation in the United States has affected a broader array of goods and services compared to other countries, in part because of strong consumer demand. Earlier in the pandemic, people stuck at home ramped up spending on items like exercise bikes and work-from-home equipment. Supply chain disruptions also made it harder to produce and transport goods around the world, leading to a spike in prices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="luF3zk">
Inflation in Europe has mainly been driven by rising energy and food costs as a result of the war in Ukraine, Dynan said. If energy and food costs subsided, that would significantly help ease rising prices in European countries, but that would have less of an impact on bringing down overall inflation in America, she said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lRxppu">
“In the United States, that’s not enough to take care of our inflation problem because our inflation is broader,” Dynan said.
</p>
<h3 id="zfMVYt">
China’s economic slowdown
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3Z9A5F">
China is under “extreme duress” because of its stringent Covid policies and weakening property industry, said Kenneth Rogoff, an economics professor at Harvard University and a former chief economist at the IMF.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="24IKwi">
China’s economy — the world’s second-largest — has taken a toll because of its attempts to eradicate Covid outbreaks through extensive lockdowns and mass testing efforts. Although economists expect China’s economy to <a href="https://www.oecd-ilibrary.org/sites/f6da2159-en/1/3/2/9/index.html?itemId=/content/publication/f6da2159-en&amp;_csp_=761d023775ff288a22ebcaaa183fbd6c&amp;itemIGO=oecd&amp;itemContentType=book">rebound in growth</a> next year as restrictions potentially ease, the “zero-Covid” approach has already disrupted the production of goods, weakened consumer spending, and led to growing <a href="https://apnews.com/article/health-china-beijing-xi-jinping-shanghai-8d0cbd9eb026f46b24316c573df2e3a2">protests against</a> the policies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6bhRaM">
The nation’s property sector, which makes up about one-fifth of economic activity in China, has also significantly weakened. For years, China’s housing industry saw rising sales and real estate prices. But excessive borrowing from developers has led to construction delays and falling home prices in the past year, sparking anger among Chinese homeowners. The <a href="https://www.wsj.com/articles/investors-cheer-beijings-plan-to-support-chinas-housing-market-but-challenges-remain-11668423791">Chinese government issued several directives earlier this month to boost its property industry</a>, but economists say the sector is unlikely to see a quick rebound.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W5qCGj">
Although Rogoff said the United States economy is in “distinctly better shape right now” compared to European countries and China, he said a weaker global economy has many negative implications for American consumers. If consumers in other countries can’t afford to buy as many American goods, that can hurt American businesses and their exports. If businesses with large operations abroad are earning fewer profits in those countries, that could translate into lower salaries for their workers in America, Rogoff said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6x5h31">
And even though the US economy is holding up now, the country could still see a painful downturn in the coming months as the Fed continues to raise interest rates.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fgHXwG">
“If we over-tighten, we’ll probably be doing worse than Asia,” Rogoff said. “Whether we’ll be doing worse than Europe, that’s a low bar.”
</p></li>
<li><strong>The not-so-lame duck session</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/rm4oAJ_wTlbGznUthfofS3kTc60=/757x0:6845x4566/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71630031/1241179775.0.jpg"/>
<figcaption>
House Speaker Nancy Pelosi talks with Senate Majority Leader Chuck Schumer during the Moms Demand Action Gun Violence Rally on June 8, 2022, in Washington, DC. | Nathan Howard/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Democrats are eyeing votes on same-sex marriage protections and electoral reforms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FIYJk2">
Now that Congress is back from its Thanksgiving recess, the lame duck session is firmly underway.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sjpcS5">
It’s expected to be a busy few weeks. <a href="https://www.vox.com/policy-and-politics/23439492/midterm-elections-2022-results-house-majority-republicans">Republicans have retaken the House</a>, so Democrats have until the beginning of January to pass any lingering legislation they’d like to get through before losing unified control.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hba6Kt">
On top of that, lawmakers still have to address must-pass bills like government funding and the authorization of defense spending, both of which they need to wrap before year’s end. If they don’t, the government could potentially shut down and the military could see major planning delays.<strong> </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nr2ybq">
Beyond the routine business on their docket, Democrats are eyeing two big bills: legislation to enshrine protections for same-sex marriage into federal law, and a measure to reform the way Congress certifies election results. Other priorities, including immigration reform and an assault weapons ban, have also been raised, though getting enough GOP support to get them through the Senate is likely to be more of a long shot.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EpXSGJ">
In the last two decades, when congressional power changed hands, lame-duck sessions have been frenetic in large part because they’re the final opportunity for a party to accomplish some of their key priorities. <a href="https://www.pewresearch.org/fact-tank/2021/01/21/nothing-lame-about-this-lame-duck-116th-congress-had-busiest-post-election-session-in-recent-history/">According to Pew</a>, these sessions have accounted for more than a quarter of Congress’s legislative output in recent terms. This year is shaping up to be no different.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XARhTF">
Below is a rundown of a few of the bills Congress has on tap for its lame-duck session this year — and where they currently stand.
</p>
<h3 id="F7e8dB">
These bills are likely to advance
</h3>
<h4 id="JpnEAj">
Same-sex marriage protections
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mgOIKk">
The Senate is expected to pass same-sex marriage protections this week after 12 Republicans expressed their support for the bill earlier this month. Because of changes that senators made to the legislation in order to win that GOP support, the House will also have to vote on the bill a second time, and is expected to pass it as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PoFXKc">
A procedural Senate vote in November revealed that the legislation has enough support to clear a 60-vote threshold: Republican Sens. Susan Collins (ME), Rob Portman (OH), Thom Tillis (NC), Lisa Murkowski (AK), Mitt Romney (UT), Roy Blunt (MO), Richard Burr (NC), Shelley Moore Capito (WV), Cynthia Lummis (WY), Dan Sullivan (AK), Todd Young (IN) and Joni Ernst (IA) joined with the 50-member Democratic caucus to vote in favor of the bill. Their votes suggest the legislation will pass the Senate when lawmakers vote on final passage later this week following another procedural vote on Monday.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pD65DE">
The <a href="https://www.vox.com/2022/7/20/23271255/respect-for-marriage-act-house-vote-republicans-senate">House approved the bill,</a> with 47 Republicans joining 220 Democrats in voting yes, this past July. The House will vote on the new version of the bill — which contains added language on protecting religious liberties — later this week.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Vqq4Zb">
Senate <a href="https://www.vox.com/policy-and-politics/2022/9/15/23355400/senate-same-sex-marriage-vote-baldwin">Democrats had postponed a vote on this bill</a> until after the midterms because they believed they’d be able to get more Republican votes once those lawmakers were less worried about alienating conservative Christian voters. Republicans said, in turn, that they would be more open to considering the legislation if it didn’t feel like it was being used for political messaging during the midterms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OAA0t5">
The bill would repeal the 1996 Defense of Marriage Act, approved during President Bill Clinton’s administration, which defined marriage as a legal union between a man and a woman, and would guarantee recognition of same-sex and interracial marriages under federal law.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="blXC24">
The new legislation is both historic and central to guaranteeing same-sex marriage protections. It became a Democratic priority following an opinion from Supreme Court Justice Clarence Thomas, in which he floated potentially revisiting <em>Obergefell v. Hodges, </em>the judicial decision that established such rights in 2015. The Supreme Court’s decision to overturn <em>Roe v. Wade</em> has raised the possibility that the panel could do the same with other precedents.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xm8Xvh">
The support that the legislation has represents a major shift, though the majority of both House and Senate Republicans are still opposed to the measure. Some Republicans — including Sens. John Cornyn (TX) and Marco Rubio (FL) — have previously said they don’t support the bill because they don’t think these rights are being threatened.
</p>
<h4 id="Kotizj">
Electoral Count Act reforms
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DZaAPe">
There’s been a bipartisan push to reform <a href="https://www.vox.com/policy-and-politics/2022/9/13/23344990/electoral-count-reform-act">the Electoral Count Act</a>,<strong> </strong>which lays out Congress’s role in counting electoral votes following a presidential election, but it’s still waiting on a vote in the Senate.<strong> </strong>This bill would update the ECA in a bid to prevent elected officials from using the process to overturn the election results, like former President Donald Trump attempted to do in 2021. Key reforms include clarifying the vice president’s role in the counting process as purely ceremonial and increasing the threshold of lawmakers it takes to challenge the results of an election. Currently, it takes just one Senate and one House member to object to a state’s outcome in order for Congress to consider and vote on the objection.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jxQjIx">
In September, the House passed its version of these reforms and the Senate is likely to do the same in the coming weeks. At this point, more than 10 Republicans have expressed their support for the bill, a strong sign that it will pass. <a href="https://www.vox.com/policy-and-politics/2022/9/13/23344990/electoral-count-reform-act">As Vox’s Ben Jacobs has explained</a>, these policies aren’t enough to guarantee that another January 6 won’t happen, though they can eliminate some legal loopholes bad actors may try to exploit.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ukcun4">
The Senate’s version of the bill differs from the House’s, however, so the lower chamber will probably have to consider the legislation again. One difference includes the threshold for challenging a state’s results: The House’s bill would require one-third of lawmakers in both chambers to sign on, while the Senate’s would require one-fifth of lawmakers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CxC1dC">
The House could approve the Senate version after it’s passed, though the process could take longer if the two chambers seek to reconcile some of the differences in the bills. <a href="https://www.politico.com/newsletters/playbook/2022/11/28/we-run-down-the-year-end-sprint-00070912">As Politico reported,</a> there’s also a possibility that lawmakers try to attach this legislation to either the must-pass government funding package or the National Defense Authorization Act, given how little floor time Congress has left before the end of the year.
</p>
<h4 id="LTwxSB">
Funding the government
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iJGOYT">
The deadline to keep the government open is now December 16, when a short-term spending bill passed earlier this year is due to expire.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="loRIkY">
Lawmakers have the option of passing another short-term bill, also known as a continuing resolution (CR), or the full-year appropriations bills that would fund different government agencies and programs. Because they’re still negotiating figures for the larger spending bills, Congress could pass a week-long CR to buy themselves more time and extend their deadline to December 23.<strong> </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cvp25Z">
If they fail to approve either a full-year bill or another CR, the government would shut down, furloughing employees and significantly curtailing certain services.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2gyYxJ">
Key appropriations requests include roughly $38 billion more in aid to Ukraine as well as $10 billion in pandemic aid to further the distribution of vaccines and medication. Both could see some Republican opposition, with the GOP split on additional support for Ukraine, and most of the party balking at additional money to address the pandemic.
</p>
<h3 id="hxWAHK">
Authorizing defense spending
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="heNcqw">
Another must-pass bill that Congress has to consider is the National Defense Authorization Act, which establishes funding allocations for the defense department.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S0silk">
There was speculation that Sen. Joe Manchin’s permitting reform bill, which previously <a href="https://www.vox.com/policy-and-politics/2022/9/13/23351561/joe-manchin-permitting-reforms-progressives-inflation-reduction-act">garnered opposition</a> from Republicans and progressive Democrats, could be attached to the NDAA. The prospect of that happening is looking less promising <a href="https://rollcall.com/2022/11/21/permitting-legislation-finds-roadblocks-in-path-to-ndaa/">due to ongoing GOP pushback</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9VuEcv">
This bill would streamline the approval process for fossil fuel and clean energy projects, and guarantee permits for the Mountain Valley Pipeline, a natural gas project in West Virginia, Manchin’s home state. Progressives had pushed back on the legislation because of the inclusion of the pipeline and the concern that the approval process Manchin envisions would dilute communities’ opportunities to weigh in on these projects. Republicans, meanwhile, felt the reforms wouldn’t expedite projects enough, and also weren’t interested in giving Manchin a win following his support for the Inflation Reduction Act.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fpaGB1">
It’s not yet clear whether Manchin will tweak his bill to address some of these concerns, or if it will have to be dropped yet again <a href="https://www.vox.com/policy-and-politics/2022/9/27/23375059/joe-manchin-permitting-reform-progressives-republicans">after it wasn’t able to pick up sufficient votes in September</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5EI1yS">
<a href="https://www.defensenews.com/congress/budget/2022/11/16/mccarthy-threatens-to-hold-up-key-defense-bill-until-next-year/">In mid-November,</a> House Minority Leader Kevin McCarthy signaled an interest in postponing an NDAA vote until next year when House Republicans will be able to send more of a message with the measure. McCarthy has argued that Democrats were trying to promote “woke” policies with the bill, though he did not detail what he meant by that. <a href="https://www.politico.com/news/2022/11/18/house-gop-vs-the-pentagon-get-ready-for-the-woke-wars-00069557">As Politico reported,</a> Republican critiques have included policies like mask mandates and diversity initiatives in the military.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hKGPRh">
Because certain House Democrats often vote against the NDAA in order to express their opposition to defense spending, the party will likely need some Republican support in order to pass the bill. Depending on how aggressively McCarthy sticks by and pushes a potential delay, that support could be tougher to obtain this year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yTUsPi">
It would be surprising if Congress doesn’t pass the NDAA before 2023, however, since it’s done so for the past 61 years.
</p>
<h3 id="PXCV9B">
These bills have also been floated
</h3>
<h4 id="yOdwvc">
(Maybe) raising the debt ceiling
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kZG6Aj">
Democrats also have the chance to raise the debt ceiling and stave off a potentially calamitous stand-off that could happen next year if Republicans take the House.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FbKMzu">
Increasing or suspending the debt ceiling (basically, the amount the US is able to borrow) is a routine action Congress has to take because if it doesn’t, the US could default on its bills and destabilize the country’s economy. Despite that, it’s a moment Republicans have indicated that they will use for leverage to secure cuts to funding for social programs and clean energy initiatives.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2UetbS">
Democrats could prevent this from happening by approving a massive increase while they still control both the House and the Senate this year, though the US is not projected to hit the debt ceiling until sometime in 2023.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5wEPyv">
Because of that timing, as well as Congress’s packed schedule, it’s not clear if they will get to that priority before next year.
</p>
<h4 id="PFbZUu">
Immigration reform
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9YLZY2">
Congress is trying, once again, to pass immigration reform, an ambition that’s been thwarted repeatedly in the last decade.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iJ5aN3">
Some Democrats are pushing legislation that would provide DACA recipients — undocumented immigrants who came to the US as children — a pathway to citizenship, after members of the program have been stuck in limbo for years. The program has faced numerous court challenges, though the Biden administration has sought to keep it intact. Legislation from Congress would help provide DACA recipients with more permanent status and offer a pathway to citizenship that doesn’t currently exist.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lVJAkc">
The main holdup for this legislation is in the Senate, where it needs 10 Republicans to sign on in order to pass. Sen. Dick Durbin (D-IL), a longtime leader of immigration negotiations, has said he knows of <a href="https://www.cnn.com/2022/11/21/politics/daca-senate-dreamers-citizenship/index.html">four or five Republicans</a> who’d be open to the bill, but the legislation would require more to actually advance.
</p>
<h4 id="v7UMRg">
<strong>An assault weapons ban</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rWUJbq">
In the wake of a <a href="https://www.vox.com/23142734/america-mass-shooting-gun-violence-control">series of mass shootings in recent weeks</a>, Democrats have raised the possibility of approving an assault weapons ban, though the measure isn’t likely to have sufficient Republican support in the Senate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qZ74XN">
Such a <a href="https://www.pbs.org/newshour/politics/house-to-vote-on-semi-automatic-gun-ban">ban would bar the sale of semi-automatic firearms</a>, which are able to fire off many rounds of ammunition extremely quickly. <a href="https://apnews.com/article/biden-gun-violence-colorado-shootings-f85b4b9a59e3852868950d797f79a351">As the Associated Press’s Colleen Long, Mary Clare Jalonick, and Lindsay Whitehurst write</a>, these weapons include “a group of high-powered guns or semi-automatic long rifles, like an AR-15, that can fire 30 rounds fast without reloading.” <a href="https://thehill.com/homenews/state-watch/3751733-colorado-governor-says-he-will-take-a-hard-look-at-why-red-flag-law-failed-to-stop-club-q-shooting/">In November,</a> a shooter used an assault-style rifle to kill five people and injure several others at an LGBTQ night club in Colorado Springs, Colorado.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B91hnc">
Sen. Chris Murphy (D-CT), a leading architect of Congress’s <a href="https://www.vox.com/2022/6/12/23162944/gun-control-bipartisan-framework">bipartisan gun control package</a>, noted Senate backing would be the primary obstacle, but that Democrats would continue to push the issue. Previously, Congress passed an assault weapons ban in 1994, but lawmakers were unable to renew it after it lapsed a decade later.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qNdmiO">
“The House has already passed it. It’s sitting in front of the Senate. Does it have 60 votes in the Senate right now? Probably not,” <a href="https://twitter.com/thehill/status/1597010128284286977">Murphy said in an interview</a> on CNN’s <em>State of the Union</em>. “But let’s see if we can try to get that number as close to 60 as possible.”
</p>
<h3 id="g3U2Fp">
Recent lame ducks have been pretty productive
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tSdf2O">
Lame-duck sessions were once pretty sporadic affairs, though they’ve become much more common, and productive, in recent years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PmrTQc">
Since 2000, especially, a decent chunk of Congress’s output has actually taken place during lame-duck sessions, <a href="https://www.pewresearch.org/fact-tank/2021/01/21/nothing-lame-about-this-lame-duck-116th-congress-had-busiest-post-election-session-in-recent-history/">per Pew</a>. During the last Congress, nearly 44 percent of what it passed — including a major coronavirus relief package — was approved during this session.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1kEMdi">
Other active lame-duck sessions include 2010, when Democrats lost control of the House, and passed several major bills before they handed it over to Republicans. They repealed “Don’t Ask, Don’t Tell,” passed a nuclear arms reduction treaty with Russia and approved an extension of tax cuts established during the Bush administration, according to <a href="https://www.theatlantic.com/politics/archive/2010/12/the-most-productive-lame-duck-since-wwii-and-maybe-ever/68442/">the Atlantic</a>. Prior to the shift in congressional power in 2019, Republicans also used the lame-duck session to approve the First Step Act, a groundbreaking criminal justice reform bill, as well as a reauthorization of the farm bill, which authorizes spending for Agriculture Department programs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oMfDrr">
This year is poised to be another busy lame-duck session, particularly since this is Democrats’ last chance to shepherd bills through before Republicans regain House control.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4pMaVC">
<em><strong>Update, November 28, 2:45 pm ET: </strong></em><em>This story was originally published on November 15 and has been updated to reflect developments regarding specific bills. </em>
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Silver Bells, Wall Street and Eaton Square excel</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Touch Of Grey, Fort Nelson, Activated, Divine Ray and Bold Act impress</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Data Point | Down the World Cup memory lane: When Asian, African and North American nations challenged the giants of football</strong> - Of the 488 countries that entered the group stages, 50% were from Europe, 18% from South America, while only 10% or less were from Africa, Asia and North America each</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FIFA World Cup 2022 | Argentina plays Poland for survival at World Cup</strong> - Lionel Messi has already come to Argentina’s rescue at the World Cup and he might have to do it all over again</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mattia Binotto resigns as Ferrari F1 team boss</strong> - Italian media have suggested Ferrari Chief Executive Benedetto Vigna could take on the role of team principal on an interim basis</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Moily slams Rijiju on collegium remarks, says system is time-tested</strong> - Mr. Moily’s remarks come a day after the Supreme Court expressed “anguish” over the delay by the Centre in clearing the names recommended by the collegium for appointment of judges in the higher judiciary</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gujarat polls | BJP slams Kharge for ‘Ravan’ jibe at PM Modi, Congress calls it ruling party’s ‘anti-Dalit tirade’</strong> - Sambit Patra alleged Mallikarjun Kharge was voicing the views of former Congress presidents Sonia and Rahul Gandhi</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IFFK lifetime achievement award for Hungarian filmmaker Bela Tarr</strong> - Chief Minister Pinarayi Vijayan will present the award to the filmmaker at the closing ceremony to be held on December 16</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Delhi court gives permission for narco analysis of Mehrauli murder accused</strong> - Narco analysis is also known as truth serum.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SC permits Mumbai Metro to pursue its plea for felling 84 trees at Aarey Colony</strong> - “The MMRCL should be permitted to pursue its application with the Tree Authority for felling 84 trees,” a Bench comprising Chief Justice D.Y. Chandrachud and Justice P.S. Narasimha said and fixed the main pleas against the Metro project for final hearing in February next year</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Russia hits out as Pope labels minority ethnic soldiers ‘cruel’</strong> - Chechens and Buryat soldiers are generally “crueller” than other Russians in Ukraine, the pontiff says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Chornobaivka airbase, symbol of Russian defeat</strong> - Chornobaivka has earned its status as one of the most important battlefields of the war.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Spanish coastguard finds stowaways on ship rudder</strong> - Three people are being treated for dehydration after the 11-day voyage from Lagos in Nigeria.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Operation Desert Light: Europol take down massive cocaine ‘super cartel’</strong> - Over 40 arrests were made across six countries, dismantling a massive criminal network, police say.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Meta fined €265m by Irish data watchdog over breach</strong> - The Irish Data Protection Commission says its inquiry has found Meta breached GDPR rules.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple Watch Ultra becomes a diving computer with launch of Oceanic+</strong> - App adds yet another Apple-sanctioned subscription service to Apple devices - <a href="https://arstechnica.com/?p=1900415">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Patent detects in-game “collusion” by tracking “external connections”</strong> - Algorithm also analyzes in-game data to find opponents secretly working together. - <a href="https://arstechnica.com/?p=1900502">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nvidia AI plays Minecraft, wins machine learning conference award</strong> - NeurIPS 2022 honors MineDojo for playing <em>Minecraft</em> when instructed by written prompts. - <a href="https://arstechnica.com/?p=1900448">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Regulatory filings suggest Nvidia’s scrapped RTX 4080 will return as the “4070 Ti”</strong> - New branding is more consistent with older 1070 and 2070-series GPUs. - <a href="https://arstechnica.com/?p=1900465">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comcast’s sneaky Broadcast TV fee hits $27, making a mockery of advertised rates</strong> - Comcast’s advertised prices don’t include ever-rising Broadcast TV and sports fees. - <a href="https://arstechnica.com/?p=1900423">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A friend of mine invited me over for a threesome with a girl.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I was hesitant at first but eventually agreed. So I went over to his place and we got started. I just couldn’t get into it. A half hour in, I started wondering when the girl is going to show up.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/tangre79"> /u/tangre79 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/z77idk/a_friend_of_mine_invited_me_over_for_a_threesome/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/z77idk/a_friend_of_mine_invited_me_over_for_a_threesome/">[comments]</a></span></p></li>
<li><strong>Stingy old lawyer</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A stingy old lawyer who had been diagnosed with a terminal illness was determined to prove wrong the old saying, “You can’t take it with you.” After much thought and consideration, the old ambulance-chaser finally figured out how to take at least some of his money with him when he died.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He instructed his wife to go to the bank and withdraw enough money to fill two pillowcases. He then directed her to take the bags of money to the attic and leave them directly above his bed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His plan: When he passed away, he would reach out and grab the bags on his way to heaven. Several weeks after the funeral, the deceased lawyer’s wife, up in the attic cleaning came upon the two forgotten pillowcases stuffed with cash.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Oh, that old fool,” she exclaimed. “I knew he should have had me put the money in the basement.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Goatmanthealien"> /u/Goatmanthealien </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/z7fex0/stingy_old_lawyer/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/z7fex0/stingy_old_lawyer/">[comments]</a></span></p></li>
<li><strong>A man’s wife doesn’t come home one night.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The next morning, the wife tells her husband that she had slept over at a friends house. The husband then contacted all of his wife’s friends asking about it: none of them said that she was staying the night.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A few nights later, the husband doesn’t come home one night. Just like his wife, the next morning he tells her that he had slept over at a friends place. His wife then contacted all of the husbands friends to ask about: and apparently the husband was at 8 houses, 2 of which said he was still there!
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Crimson_talon"> /u/Crimson_talon </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/z76h7b/a_mans_wife_doesnt_come_home_one_night/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/z76h7b/a_mans_wife_doesnt_come_home_one_night/">[comments]</a></span></p></li>
<li><strong>My grief counselor died today.</strong> - <!-- SC_OFF -->
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She was very good, I don’t even care.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/r0gerii"> /u/r0gerii </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/z7j54b/my_grief_counselor_died_today/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/z7j54b/my_grief_counselor_died_today/">[comments]</a></span></p></li>
<li><strong>Three dinosaurs are running across the desert when they stumble upon a magic lamp.</strong> - <!-- SC_OFF -->
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They rub it, and a genie appears.
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“I have three wishes, so I’ll give one to each of you,” the genie announces.
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The first dinosaur thinks hard.
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“Alright,” he says, “I’ll have a big, juicy, piece of meat.”
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Instantly, the biggest, juiciest piece of meat he’d ever seen appears in front of him.
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Not to be outdone, the second dinosaur thinks even harder.
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“I know! I’ll have a shower of meat!”
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Immediately, huge pieces of meat rain down around him.
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The third dinosaur, certainly not to be outdone, thinks harder than the previous dinosaurs.
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“I’ve got it!” he cries, “I want a MEATIER shower!”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MudakMudakov"> /u/MudakMudakov </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/z6wk4x/three_dinosaurs_are_running_across_the_desert/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/z6wk4x/three_dinosaurs_are_running_across_the_desert/">[comments]</a></span></p></li>
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