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<title>04 February, 2022</title>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It has been proposed that as SARS-CoV-2 transitions to endemicity, children will represent the greatest proportion of SARS-Co-V-2 infections as they currently do with endemic coronavirus infections. While SARS-CoV-2 infection severity is low for children, it is unclear if SARS-CoV-2 infections are distinct in symptom presentation, duration, and severity from endemic coronavirus infections in children. We compared symptom risk and duration of endemic human coronavirus (HCoV) infections from 2011-2016 with SARS-CoV-2 infections from March 2020-September 2021 in a Nicaraguan pediatric cohort. Blood samples were collected from study participants annually in February-April. Respiratory samples were collected from participants that met testing criteria. Blood samples collected in were tested for SARS-CoV-2 antibodies and a subset of 2011-2016 blood samples from four-year-old children were tested for endemic HCoV antibodies. Respiratory samples were tested for each of the endemic HCoVs from 2011-2016 and for SARS-CoV-2 from 2020-2021 via rt-PCR. By April 2021, 854 (49%) cohort participants were ELISA positive for SARS-CoV-2 antibodies. Most participants had antibodies against one alpha and one beta coronavirus by age four. We observed 595 symptomatic endemic HCoV infections from 2011-2016 and 121 symptomatic with SARS-CoV-2 infections from March 2020-September 2021. Symptom presentation of SARS-CoV-2 infection and endemic coronavirus infections were very similar, and SARS-CoV-2 symptomatic infections were as or less severe on average than endemic HCoV infections. This suggests that, for children, SARS-CoV-2 may be just another endemic coronavirus. However, questions about the impact of variants and the long-term effects of SARS-CoV-2 remain.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.12.09.21267537v2" target="_blank">SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children</a>
</div></li>
<li><strong>Unraveling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent-RNA-Polymerase. An Unusual Active Site Leading to High Replication Rates.</strong> -
<div>
Viral infection relies on the hijacking of cellular machineries to enforce the reproduc- tion of the infecting virus and its subsequent diffusion. In this context the replication of the viral genome is a key step performed by specific enzymes, i.e. polymerases. The replication of SARS-CoV-2, the causative agent of the COVID-19 pandemics, is based on the duplication of its RNA genome, an action performed by the viral RNA- dependent-RNA polymerase. In this contribution, for the first time and by using two- dimensional enhanced sampling quantum mechanics/ molecular mechanics, we have determined the chemical mechanisms leading to the inclusion of a nucleotide in the nascent viral RNA strand. We prove the high efficiency of the polymerase, which low- ers the activation free energy to less than 10 kcal/mol. Furthermore, the SARS-CoV-2 polymerase active site is slightly different from those found usually found in other similar enzymes, and particularly it lacks the possibility to enforce a proton shuttle via a nearby histidine. Our simulations show that this absence is partially compensate by lysine, whose proton assist the reaction opening up an alternative, but highly efficient, reactive channel. Our results present the first mechanistic resolution of SARS-CoV-2 genome replication and shed light on unusual enzymatic reactivity paving the way for future rational design of antivirals targeting emerging RNA viruses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.02.02.478873v1" target="_blank">Unraveling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent-RNA-Polymerase. An Unusual Active Site Leading to High Replication Rates.</a>
</div></li>
<li><strong>Is mandatory vaccination in population over 60 adequate to control the COVID-19 pandemic in E.U.?</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Vaccine hesitancy, which potentially leads to refusal or delayed acceptance of COVID-19 vaccines, is considered a key driver for the increasing death toll from the pandemic in the E.U.. European Commission and several member states governments are either planning or have already directly or indirectly announced mandatory vaccination for individuals aged over 60, the group repeatedly proved to be the most vulnerable. In this paper, an assessment of this strategy benefits is attempted. This is done by examining the reduction of Standard Expected Years of Life Lost (SEYLL) per person of the EU population over 60 as a function of their vaccination percentage. Publicly available data and some first results of the second iteration of the SHARE COVID-19 survey conducted during the summer of 2021 on acceptance of COVID-19 vaccines are used as input.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.01.25.22269867v2" target="_blank">Is mandatory vaccination in population over 60 adequate to control the COVID-19 pandemic in E.U.?</a>
</div></li>
<li><strong>A population framework for predicting the proportion of people infected by the far-field airborne transmission of SARS-CoV-2 indoors</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The number of occupants in a space influences the risk of far-field airborne transmission of SARS-CoV-2 because the likelihood of having infectious and susceptible people both correlate with the number of occupants. This paper explores the relationship between occupancy and the probability of infection, and how this affects an individual person and a population of people. Mass-balance and dose-response models determine far-field transmission risks for an individual person and a population of people after sub-dividing a large reference space into 10 identical comparator spaces. For a single infected person, the dose received by an individual person in the comparator space is 10-times higher because the equivalent ventilation rate per infected person is lower when the per capita ventilation rate is preserved. However, accounting for population dispersion, such as the community prevalence of the virus, the probability of an infected person being present and uncertainty in their viral load, shows the transmission probability increases with occupancy and the reference space has a higher transmission risk. Also, far-field transmission is likely to be a rare event that requires a high emission rate, and there are a set of Goldilocks conditions that are just right when ventilation is effective at mitigating against transmission. These conditions depend on the viral load, because when they are very high or low, ventilation has little effect on transmission risk. Nevertheless, resilient buildings should deliver the equivalent ventilation rate required by standards as minimum.
</p>
</div>
<div class="article-link article- html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.11.24.21266807v3" target="_blank">A population framework for predicting the proportion of people infected by the far-field airborne transmission of SARS- CoV-2 indoors</a>
</div></li>
<li><strong>COVID-19 infection enhances susceptibility to oxidative-stress induced parkinsonism</strong> -
<div>
Background: Viral induction of neurological syndromes has been a concern since parkinsonian-like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities in the systemic responses following SARS-CoV-2 infection with those observed after pandemic influenza, there is a question if a similar syndrome of post-encephalic parkinsonism could follow COVID-19 infection. Objectives: To determine if prior infection with SARS-CoV-2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism. Methods: hACE2 mice were infected with SARS-CoV-2 to induce mild to moderate disease. After 31 days recovery, mice were administered a non-lesion inducing dose of the parkinsonian toxin MPTP. Subsequent neuroinflammation and SNpc dopaminergic neuron loss was determined and compared to SARS-CoV-2 or MPTP alone. Results: hACE2 mice infected with SARS-CoV-2 or MPTP showed no SNpc DA neuron loss following MPTP. In mice infected and recovered from SARS-CoV-2 infection, MPTP induced a 23% or 19% greater loss of SNpc dopaminergic neurons than SARS-CoV-2 or MPTP, respectively (p &lt; 0.05). Examination of microglial activation showed a significant increase in the number of activated microglia in the SARS-CoV-2 + MPTP group compared to SARS-CoV-2 or MPTP alone. Conclusions: Our observations have important implications for long-term public health, given the number of people that have survived SARS-CoV-2 infection as well as for future public policy regarding infection mitigation. However, it will be critical to determine if other agents known to increase risk of PD also have synergistic effects with SARS-CoV-2 and if are abrogated by vaccination.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.02.02.478719v1" target="_blank">COVID-19 infection enhances susceptibility to oxidative-stress induced parkinsonism</a>
</div></li>
<li><strong>Development and optimisation of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: evaluation of 5676 phase 1 passed structures</strong> -
<div>
Although vaccines are currently used to control the coronavirus disease 2019 (COVID-19) pandemic, treatment options are urgently needed for those who cannot be vaccinated and for future outbreaks involving new severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) strains or coronaviruses not covered by current vaccines. Thus far, few existing antivirals are known to be effective against SARS-CoV-2 and clinically successful against COVID-19. As part of an immediate response to the COVID-19 pandemic, a high-throughput, high content imaging-based SARS-CoV-2 infection assay was developed in VeroE6-eGFP cells and was used to screen a library of 5676 compounds that passed phase 1 clinical trials. Eight candidates (nelfinavir, RG-12915, itraconazole, chloroquine, hydroxychloroquine, sematilide, remdesivir, and doxorubicin) with in vitro anti-SARS-CoV-2 activity in VeroE6-eGFP and/or Caco-2 cell lines were identified. However, apart from remdesivir, toxicity and pharmacokinetic data did not support further clinical development of these compounds for COVID-19 treatment.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.02.02.478671v1" target="_blank">Development and optimisation of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: evaluation of 5676 phase 1 passed structures</a>
</div></li>
<li><strong>Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: a randomized, controlled, open-label, parallel group trial (DOXPREVENT.ICU)</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
<b>Background:</b> After admission to hospital, COVID-19 progresses in a substantial proportion of patients to critical disease that requires intensive care unit (ICU) admission. <b>Methods:</b> In a pragmatic, non-blinded trial, 387 patients aged 40-90 years were randomised to receive treatment with SoC plus doxycycline (n=192) or SoC only (n=195). The primary outcome was the need for ICU admission as judged by the attending physicians. Three types of analyses were carried out for the primary outcome: Intention to treat (ITT) based on randomisation; Per protocol (PP), excluding patients not treated according to randomisation; and As treated (AT), based on actual treatment received. The trial was undertaken in six hospitals in India with high-quality ICU facilities. An online application serving as the electronic case report form was developed to enable screening, randomisation and collection of outcomes data. <b>Results:</b> Adherence to treatment per protocol was 95.1%. Among all 387 participants, 77 (19.9%) developed critical disease needing ICU admission. In all three primary outcome analyses, doxycycline was associated with a relative risk reduction (RRR) and absolute risk reduction (ARR): ITT 31.6% RRR, 7.4% ARR (P=0.063); PP 40.7% RRR, 9.6% ARR (P=0.017); AT 43.2% RRR, 10.8% ARR (P=0.007), with numbers needed to treat (NTT) of 13.4 (ITT), 10.4 (PP), and 9.3 (AT), respectively. Doxycycline was well tolerated with not a single patient stopping treatment due to adverse events. <b>Conclusions:</b> In hospitalized COVID-19 patients, doxycycline, a safe, inexpensive, and widely available antibiotic with anti-inflammatory properties, reduces the need for ICU admission when added to SoC.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.01.30.22269685v1" target="_blank">Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: a randomized, controlled, open- label, parallel group trial (DOXPREVENT.ICU)</a>
</div></li>
<li><strong>COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Laboratory tests for the accurate and rapid identification of SARS-CoV-2 variants can potentially guide the treatment of COVID-19 patients and inform infection control and public health surveillance efforts. Here we present the development and validation of a rapid COVID-19 variant DETECTR assay incorporating loop-mediated isothermal amplification (LAMP) followed by CRISPR-Cas12 based identification of single nucleotide polymorphism (SNP) mutations in the SARS-CoV-2 spike (S) gene. This assay targets the L452R, E484K/Q/A, and N501Y mutations that are associated with nearly all circulating viral lineages and identifies the two circulating variants of concern, Delta and Omicron. In a comparison of three different Cas12 enzymes, only the newly identified enzyme CasDx1 was able to accurately identify all targeted SNP mutations. An analysis pipeline for CRISPR-based SNP identification from 139 clinical samples yielded an overall SNP concordance of 98% and agreement with SARS-CoV-2 lineage classification of 138/139 compared to viral whole- genome sequencing. We also showed that detection of the single E484A mutation was necessary and sufficient to accurately identify Omicron from other major circulating variants in patient samples. These findings demonstrate the utility of CRISPR-based DETECTR as a faster and simpler diagnostic than sequencing for SARS-CoV-2 variant identification in clinical and public health laboratories.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.11.29.21267041v2" target="_blank">COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme</a>
</div></li>
<li><strong>Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine</strong> -
<div>
In late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodies. Within weeks of the first report of B.1.1.529, this VoC has rapidly spread throughout the world, replacing previously circulating strains of SARS-CoV-2 and leading to a resurgence in COVID-19 cases even in populations with high levels of vaccine- and infection-induced immunity. Initial studies have shown that B.1.1.529 is less sensitive to protective antibody conferred by previous infections and vaccines developed against earlier lineages of SARS-CoV-2. The ability of B.1.1.529 to spread even among vaccinated populations has led to a global public health demand for updated vaccines that can confer protection against B.1.1.529. We report here the rapid development of a replicating RNA vaccine expressing the B.1.1.529 spike and show that this B.1.1.529-targeted vaccine is immunogenic in mice and hamsters. Interestingly, we found that mice previously immunized with A.1-specific vaccines failed to elevate neutralizing antibody titers against B.1.1.529 following B.1.1.529-targeted boosting, suggesting pre-existing immunity may impact the efficacy of B.1.1.529- targeted boosters. Furthermore, we found that our B.1.1.529-targeted vaccine provides superior protection compared to the ancestral A.1-targeted vaccine in hamsters challenged with the B.1.1.529 VoC after a single dose of each vaccine.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.01.31.478520v1" target="_blank">Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine</a>
</div></li>
<li><strong>How consistent are smartphone application preferences? A longitudinal study of mobile application repertoires using behavioral data</strong> -
<div>
Smartphones afford users the ability to select their own mobile application repertoires through the installation of various applications. We report a quantitative descriptive study of the types of applications that people commonly use, the amount of time they spend with these applications, the application combinations that they construct, the consistency of these combinations over time, and the differences in these outcomes by demographic characteristics. Using a longitudinal dataset collected from a U.S. adult sample during the COVID-19 pandemic, the study leverages behavioral data collected via data donations to identify key application adoption patterns and shows that peoples’ mobile application repertoires are concentrated around a set of popular applications that is relatively consistent over time. However, within this set there is considerable diversity between individuals and applications, suggesting that quantifying smartphone usage with a single metric— ‘screentime’ —is unlikely to capture the full extent of media that users engage with.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/jzxun/" target="_blank">How consistent are smartphone application preferences? A longitudinal study of mobile application repertoires using behavioral data</a>
</div></li>
<li><strong>A mixed methods analysis of participation in social contact surveys</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background Social contact survey data forms a core component of modern epidemic models: however, there has been little assessment of the potential biases in such data. Methods We conducted focus groups with university students who had (n=13) and had not (n=14) completed a social contact survey during the COVID-19 pandemic. Qualitative findings were explored quantitatively by analysing participation data. Results The opportunity to contribute to COVID-19 research, to be heard and feel useful were frequently reported motivators for participating in the contact survey. Reductions in survey engagement following lifting of COVID-19 restrictions may have occurred because the research was perceived to be less critical and/ or because the participants were busier and had more contacts. Having a high number of contacts to report, uncertainty around how to report each contact, and concerns around confidentiality were identified as factors leading to inaccurate reporting. Focus groups participants thought that financial incentives or provision of study results would encourage participation. Conclusions Incentives could improve engagement with social contact surveys. Qualitative research can inform the format, timing, and wording of surveys to optimise completion and accuracy.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.01.28.22270006v2" target="_blank">A mixed methods analysis of participation in social contact surveys</a>
</div></li>
<li><strong>Non-Markovian modelling highlights the importance of age structure on Covid-19 epidemiological dynamics</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Covid-19 pandemic outbreak was followed by a huge amount of modelling studies in order to rapidly gain insights to implement the best public health policies. Most of these compartmental models involved ordinary differential equations (ODEs) systems. Such a formalism implicitly assumes that the time spent in each compartment does not depend on the time already spent in it, which is at odds with the clinical data. To overcome this `memoryless99 issue, a widely used solution is to increase and chain the number of compartments of a unique reality (<i>e.g.</i> have infected individual move between several compartments). This allows for greater heterogeneity and thus be closer to the observed situation, but also tends to make the whole model more difficult to apprehend and parameterize. We develop a non- Markovian alternative formalism based on partial differential equations (PDEs) instead of ODEs, which, by construction, provides a memory structure for each compartment thereby allowing us to limit the number of compartments. We apply our model to the French 2021 SARS-CoV-2 epidemic and, while accounting for vaccine-induced and natural immunity, we analyse and determine the major components that contributed to the Covid-19 hospital admissions. The results indicate that the observed vaccination rate alone is not enough to control the epidemic, and a global sensitivity analysis highlights a huge uncertainty attributable to the age-structured contact matrix. Our study shows the flexibility and robustness of PDE formalism to capture national COVID-19 dynamics and opens perspectives to study medium or long-term scenarios involving immune waning or virus evolution.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.09.30.21264339v3" target="_blank">Non-Markovian modelling highlights the importance of age structure on Covid-19 epidemiological dynamics</a>
</div></li>
<li><strong>The evolutionary functions of imagination and fiction and how they may contribute to psychological wellbeing during a pandemic</strong> -
<div>
The COVID-19 pandemic caused widespread social disruption and lockdowns, with negative consequences for psychological wellbeing worldwide. We argue that mental simulation, through the cognitive capacity of imagination and its instigator fiction, may have substantial positive contributions to psychological wellbeing during the pandemic. We review relevant research on the evolutionary functions of simulation through imagination and fiction, and propose that simulation is a tool to support (i) planning and future thought, (ii) coping and emotion regulation, (iii) bonding and social needs, and (iv) identity and worldviews. We suggest that these functions can contribute to coping during the pandemic. We also address the dark side of simulation, whereby excessive simulation may have negative effects such as rumination. In light of previous research and the negative psychological effects of COVID-19 disruptions and lockdowns, we suggest that there is much scope for future research on this topic, including whether simulations offered by imaginative activity could be useful and inexpensive mental health tools.
</div>
<div class="article-link article-html- link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/wj4zg/" target="_blank">The evolutionary functions of imagination and fiction and how they may contribute to psychological wellbeing during a pandemic</a>
</div></li>
<li><strong>Use caution when applying behavioural science to policy</strong> -
<div>
Social and behavioural scientists have attempted to speak to the COVID-19 crisis. But is behavioural research on COVID-19 suitable for making policy decisions? We offer a taxonomy that lets our science advance in Evidence Readiness Levels to be suitable for policy. We caution practitioners to take extreme care translating our findings to applications.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/whds4/" target="_blank">Use caution when applying behavioural science to policy</a>
</div></li>
<li><strong>A network perspective on real-life threat, anxiety, and avoidance</strong> -
<div>
Anxiety, approach and avoidance motivation crucially influence mental and physical health, especially when environments are stressful. The interplay between anxiety and behavioral motivation is modulated by multiple individual factors. This proof of concept study applies graph-theoretical network analysis to explore complex associations between self-reported trait anxiety, approach and avoidance motivation, situational anxiety, stress symptoms, perceived threat, perceived positive consequences of approach, and self-reported avoidance behavior in real-life threat situations. 541 participants (218 patients, 323 community) completed an online survey assessing these factors in response to the COVID-19 pandemic. The resulting cross-sectional psychological network revealed a complex pattern with multiple positive (e.g., between trait anxiety, avoidance motivation, and avoidance behavior) and negative associations (e.g., between approach and avoidance motivation). The patient and community subsample networks did not differ significantly, however, descriptive differences may inform future research.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/jnx36/" target="_blank">A network perspective on real-life threat, anxiety, and avoidance</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Safety, Tolerability, and Immunogenicity of MVC-COV1901 or MVC-COV1901(Beta) Against COVID-19</strong> - <b>Condition</b>:   COVID-19 Vaccine<br/><b>Interventions</b>:   Biological: MVC-COV1901(Beta);   Biological: MVC- COV1901<br/><b>Sponsor</b>:   Medigen Vaccine Biologics Corp.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exercise Fatigue Parameters and Endothelial Function in Pediatric Patients With a History of COVID-19 Infection or MIS-C</strong> - <b>Conditions</b>:   COVID-19;   MIS-C Associated With COVID-19<br/><b>Interventions</b>:  <br/>
Device: Cardiopulmonary exercise test (CPET);   Device: Peripheral Arterial Tonography (PAT) using the EndoPAT™ device;   Diagnostic Test: Endothelin<br/><b>Sponsors</b>:   Rambam Health Care Campus;   The Baruch Padeh Medical Center, Poriya<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluate the Efficacy and Safety of TF0023 in Treatments for COVID-19 in Hospitalized Adults</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Drug: TF0023<br/><b>Sponsor</b>:  <br/>
Techfields Inc<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Short Daily Versus Conventional Hemodialysis for COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Short daily dialysis<br/><b>Sponsor</b>:  <br/>
Shahid Beheshti University of Medical Sciences<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Non-inferiority Trial on Monoclonal Antibodies in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Bamlanivimab Etesevimab;   Drug: Sotrovimab;   Drug: Casirivimab-Imdevimab<br/><b>Sponsors</b>:   Azienda Ospedaliera Universitaria Integrata Verona;   Agenzia Italiana del Farmaco;   Azienda Sanitaria-Universitaria Integrata di Udine<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Ingavirin®, 90 mg Capsules in Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Ingavirin®, 90 mg capsules;   Drug: Placebo<br/><b>Sponsor</b>:   Valenta Pharm JSC<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Availability and Advice on Test Uptake During the COVID-19 Pandemic: a Vignette Study.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Customised testing advice;   Behavioral: Regular testing advice;   Behavioral: LFT available;   Behavioral: No LFT available<br/><b>Sponsor</b>:  <br/>
National Institute for Public Health and the Environment (RIVM)<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase IIa Randomized Placebo Controlled Clinical Study of Codivir in Hospitalized Patients With Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Covidir injections;   Diagnostic Test: Quantitative PCR SARS-CoV-2;   Diagnostic Test: IgM and IgG dosage;   Diagnostic Test: Screening Blood tests;   Diagnostic Test: Electrocardiogram;   Other: NEWS-2 score;   Other: WHO score;   Other: Physical examination;   Other: COVID-19-Related Symptoms assessment<br/><b>Sponsor</b>:   Code Pharma<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exercise in Adults With Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection Study</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Exercise Prescription<br/><b>Sponsor</b>:  <br/>
Baylor Research Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity Study of EgyVax Vaccine Candidate for Prophylaxis of COVID-19 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: EgyVax Vaccine Candidate;   Drug: Placebo<br/><b>Sponsors</b>:   Eva Pharma;   Veterinary Serum &amp; Vaccine Research Institute (VSVRI), Egypt;   The Supreme Council of University Hospitals, Egypt;   Ministry of Higher Education and Scientific Research, Egypt<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>To Evaluate Safety &amp; Immunogenicity of DelNS1-2019-nCoV-RBD-OPT1 for COVID-19 in Healthy Adults Received 2 Doses of BNT162b2</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: DelNS1-2019-nCoV-RBD-OPT1;   Biological: Matching placebo<br/><b>Sponsor</b>:   The University of Hong Kong<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Treatment of Non-Severe COVID-19 Outpatients With Xagrotin, Phase 3</strong> - <b>Condition</b>:   Sars-cov-2<br/><b>Interventions</b>:   Drug: Xagrotin;   Drug: Green tea<br/><b>Sponsor</b>:  <br/>
Biomad AS<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase 2b Booster Vaccination (TURKOVAC) Against COVID-19</strong> - <b>Conditions</b>:   COVID-19;   Sars-CoV-2 Infection<br/><b>Interventions</b>:   Biological: TURKOVAC-Dollvet;   Biological: TURKOVAC-Koçak<br/><b>Sponsor</b>:   Health Institutes of Turkey<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Synchronous and Asynchronous Telerehabilitation in COVID-19 Discharges</strong> - <b>Conditions</b>:   COVID-19;   Telerehabilitation<br/><b>Interventions</b>:  <br/>
Other: Synchronous telerehabilitation programme;   Other: Asynchronous telerehabilitation programme<br/><b>Sponsors</b>:   Bitlis Eren University;   Marmara University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intranasal Heparin Treatment to Reduce Transmission Among Household Contacts of COVID 19 Positive Adults and Children</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: unfractionated heparin;   Drug: 0.9%sodium chloride<br/><b>Sponsors</b>:   Murdoch Childrens Research Institute;   University of Melbourne;   Northern Hospital, Australia;   Monash University;   The Peter Doherty Institute for Infection and Immunity;   St Vincent’s Hospital Melbourne<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability</strong> - Immunization with SARS-CoV-2 spike elicits diverse antibodies, but can any of these neutralize broadly? Here, we report the isolation and characterization of antibody WS6, from a mouse immunized with mRNA encoding the SARS-CoV-2 spike. WS6 bound diverse beta-coronavirus spikes and neutralized SARS-CoV-2 variants, SARS-CoV, and related sarbecoviruses. Epitope mapping revealed WS6 to target a region in the S2 subunit, which was conserved among SARS-CoV-2, MERS-CoV, and hCoV- OC43. The crystal…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail</strong> - The SARS-CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralization mediated by the REGEN-CoV therapeutic monoclonal antibody (mAb) COVID-19 cocktail and the cilgavimab (AZD1061) mAb. Here, we show that this residue substitution remodels the ACE2-binding site allosterically, thereby dampening receptor recognition severely and altering the epitopes recognized by these three mAbs. Although vaccine-elicited neutralizing antibody titers are decreased similarly against the E406…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Host Chitinase 3-like-1 is a Universal Therapeutic Target for the Delta, Omicron and Other SARS-CoV-2 Viral Variants in COVID 19</strong> - COVID 19 is the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2; SC2) which has caused a world-wide pandemic with striking morbidity and mortality. Evaluation of early SC2 strains suggested limited viral genetic diversity. However, genetic and epidemiologic investigations in the interim have revealed impressive genetic variability. Many of these viral variants are now defined as variants of concern (VOC) based on genetic alterations in their spike (S) and other…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hantavirus Induced Kidney Disease</strong> - Hantavirus induced hemorrhagic fever with renal syndrome (HFRS) is an emerging viral zoonosis affecting up to 200,000 humans annually worldwide. This review article is focused on recent advances in the mechanism, epidemiology, diagnosis, and treatment of hantavirus induced HFRS. The importance of interactions between viral and host factors in the design of therapeutic strategies is discussed. Hantavirus induced HFRS is characterized by thrombocytopenia and proteinuria of varying severities. The…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Circulating Microparticles in the Pathogenesis and Early Anticoagulation of Thrombosis in COVID-19 With Kidney Injury</strong> - As more is learned about the pathophysiological mechanisms of COVID-19, systemic thrombosis has been recognized as being associated with more severe clinical manifestations, mortality and sequelae. As many as 40% of patients admitted to the hospital due to COVID-19 have acute kidney injury, with coagulation abnormalities the main cause of impaired function. However, the mechanism of renal thrombosis and the process leading to kidney injury are unclear. Microparticles (MPs) are membrane bubbles…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection</strong> - CONCLUSION: In this work, we found GA and A3 from licorice potently inhibit SARS-CoV-2 infection by affecting entry and replication of the virus. Our findings indicate that these triterpenoids may contribute to the clinical efficacy of licorice for COVID-19 and could be promising candidates for antiviral drug development.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Association of Complement C3 with Clinical Deterioration Among Hospitalized Patients with COVID-19</strong> - CONCLUSION: Low complement C3 levels are associated with a higher risk for clinical worsening among inpatients with COVID-19. The serum C3 levels may contribute to the identification of patient populations that could benefit from therapeutic complement inhibition.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Telacebec (Q203): Is there a novel effective and safe anti-tuberculosis drug on the horizon?</strong> - High prevalence and stronger emergency of various forms of drug-resistant tuberculosis (DR-TB), including the multidrug- resistant (MDR-TB) as well as extensively drug-resistant (XDR-TB) ones, caused by variously resistant Mycobacterium tuberculosis pathogens, make first-line anti-tuberculosis (anti-TB) agents therapeutically more and more ineffective. Therefore, there is an imperative to develop novel highly efficient (synthetic) agents against both drug-sensitive-TB and DR-TB. The exploration…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition</strong> - Recently, a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised global concerns, being the etiological agent of the current pandemic infectious coronavirus disease 2019 (COVID-19). Specific prophylactic treatments like vaccines, have been authorized for use by regulatory bodies in multiple countries, however there is an urgent need to identify new, safe, and targeted therapeutics as post-exposure therapy for COVID-19. Among a plethora of potential…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications</strong> - CONCLUSION: Keeping in mind that the natural alternatives are in the priority for the management and prevention of the COVID-19, the present review may help to develop an alternative approach for the management of COVID-19 viral infection and post-COVID complications from a mechanistic point of view.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and immunogenicity of a high-dose quadrivalent influenza vaccine administered concomitantly with a third dose of the mRNA-1273 SARS-CoV-2 vaccine in adults aged 65 years: a phase 2, randomised, open-label study</strong> - BACKGROUND: Concomitant seasonal influenza vaccination with a COVID-19 vaccine booster could help to minimise potential disruption to the seasonal influenza vaccination campaign and maximise protection against both diseases among individuals at risk of severe disease and hospitalisation. This study aimed to assess the safety and immunogenicity of concomitant administration of high-dose quadrivalent influenza vaccine (QIV-HD) and a mRNA-1273 vaccine booster dose in older adults.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality</strong> - The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased risk for severe COVID-19 presentation is still unknown. Here, we employed genetic association analysis to investigate the potential association of host genetic polymorphisms of ORAI1 with the risk of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nanocurcumin Potently Inhibits SARS-CoV-2 Spike Protein-Induced Cytokine Storm by Deactivation of MAPK/NF-kappaB Signaling in Epithelial Cells</strong> - Interleukin-mediated deep cytokine storm, an aggressive inflammatory response to SARS-CoV-2 virus infection in COVID-19 patients, is correlated directly with lung injury, multi-organ failure, and poor prognosis of severe COVID-19 patients. Curcumin (CUR), a phenolic antioxidant compound obtained from turmeric (Curcuma longa L.), is well-known for its strong anti-inflammatory activity. However, its in vivo efficacy is constrained due to poor bioavailability. Herein, we report that…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glucosinolates and their hydrolysis products as potential nutraceuticals to combat cytokine storm in SARS-COV-2</strong> - CONCLUSION: Accordingly, these compounds can be helpful in combating the cytokine storm associated with COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protective Effects of Exercise Become Especially Important for the Aging Immune System in The Covid-19 Era</strong> - Aging is a complex, multietiological process and a major risk factor for most non-genetic, chronic diseases including geriatric syndromes that negatively affect healthspan and longevity. In the scenario of “healthy or good aging”, especially during the COVID-19 era, the proper implementation of exercise as “adjuvant” or “polypill” to improve disease-related symptoms and comorbidities in the general population is a top priority. However, there is still a gap concerning studies analyzing influence…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IDENTIFICATION AND ALARM SYSTEM FOR FACIAL CORONA MASK USING CNN BASED IMAGE PROCESSING</strong> - tThe covid-19 epidemic is the world’s largest wake-up call for people to pay attention to their own and society’s health. One thing to keep in mind is that there is a segment of the population that has been exposed to the covid-19 virus and has generated antibodies without developing any significant illnesses and is continuing to be healthy. This indicates that a significant section of the population, even excluding the elderly, lacks the necessary bodily immunity to combat a Viral infection. As terrible as covid-19 is on a global scale, developing personal health standards and preventative measures for any pathogenic virus as a community would have spared many lives. In’this work, a camera is combined with an image processing system to recognise facial masks, which may be improved in a variety of ways. First and foremost, this method is meant to identify masks on a single person’s face. While this method is efficient in identifying someone has a mask, it does not ensure that they will wear it all of the time. The most effective update for this task is to install a camera with a wide field of view so that many individuals can be seen in the frame, and the faces of those who aren’t wearing markings can be identified, as well as the number of people and the timing. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN346889253">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ANTIMICROBIAL SANITIZING FORMULATION</strong> - An antimicrobial sanitizing formulation, comprising, i) isopropyl alcohol in the range of 0.1%- 80% w/w, ii) an emollient in the range of 0.1%-15% w/w, iii) hydrogen peroxide in the range of 0.1 0.13% w/w, iv) citric acid in the range of 0.1% to 2.0% w/w, v) silver nitrate in the range of 0.1% to 0.5% w/w, and vi) a fragrance imparting agent in the range of 0.1% to 2.0% w/w. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN346888094">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A HEALTH BAND WITH A BIOMETRIC MODULE AND WORKING METHOD THEREOF</strong> - The present invention discloses a health band with a biometric module and method thereof. The assembly includes, but not limited to, a plurality of sensors configured to gather health data associated with a predefined symptom of a medical condition of a user; a memory unit configured to store the data and an interface, which is configured to determine the medical condition using the data;a processing unit configured to execute the application; and a notification facility configured to provide a notification upon receiving from the interface an instruction associated with the notification, wherein the notification is associated with a drug reminder and the like. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN346889061">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RNA 검출 방법</strong> - 본 발명은 RNA의 분석 및 검출 방법에 관한 것이다. 특히, 본 발명은 특히, 본 발명은 짧은 염기서열의 RNA까지 분석이 가능하면서도 높은 민감도 및 정확도로 정량적 검출까지 가능하여 감염증, 암 등 여러 질환의 진단 용도로도 널리 활용될 수 있다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR346026620">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>REUNION OF PHOTOTHERMAL THERAPY WITH MXENE ADSORBED UREMIC TOXINS AND CYTOKINES: A SHILED FOR COVID-19 PATENTS</strong> - The COVID-19 pandemic has created havoc throughout the world. The disease has proved to be more fatalfor patients having comorbidities like diabetics, lungs and kidney infections, etc. In the case of COVID-19 patientsI having kidney injury, the. removal of uremic toxins from the blood is hindered and there is a rapid surge in the levelj of cytokine hormone resulting in the death of the patient in a short interval of time. To resolve this issue,iI; researchers have examined that the immediate removal of these toxins can improve the condition of the patient to a |greater extent. Studies have also found the presence of SARS CoV-2 viral RNAs in the blood of COVID-19patients, which risks their life as well as impacts the blood transfusion process, especially in the case ofasymptomatic patients. Hence it is required to control the surge of cytokines and uremic toxins as well as disinfectthe blood of the patient from the virus. MXenes, having a foam-like porous structure and hydrophilic negativesurface functionalization have greater adsorption efficiency as well as superior photothermal activity. Utilizingthese properties of MXenes, the MXene membranes can be used in the dialyzer that can help in the efficient andBiuick removal of the uremic toxins, cytokines, and other impurities from the blood. Along with this the greaterTJAdsorption efficiency of MXenes to amino acids result in the trapping of the SARS CoV-2 viruses on the surface J)3&gt;f the MXene. Many researchers as well as the WHO have proved the efficient reduction of the viral copy numbersjjvith the increase of temperature. Hence, followed by the trapping of the viruses, the implementation of"Zphotothermal Therapy can result in the inactivation and denaturation of the viruses and their respective viral RNAsBJlby the produced heat. The same process can be repeated several times to get better results. This whole process canr&gt;oQ-esult in impurity-free and infection-free blood, that can be returned back to the body of the patient or can be!— I Sitilized for the blood transfusion process without any risk of infection.IM - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN346889224">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>REDUCING AND STOPPING OXYGEN WASTAGE IN HOSPITAL</strong> - In an aspect, the present invention discloses a system (200) for prevention and reduction of oxygen wastage from oxygen mask (202). The system (200) includes the oxygen mask (202) having straps; a tension sensor (204), the tension sensor being sensitive towards tension produced in the straps as the oxygen gets leakage through sides of the mask (202); a processor configured in alignment with the tension sensor (204); and a buzzer (206) in alignment with processor. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN346042219">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>编码SARS-COV-2病毒C.37突变株抗原的DNA分子、DNA疫苗及应用</strong> - 本发明涉及生物技术领域，具体而言，提供了一种编码SARS‑COV‑2病毒C.37突变株抗原的DNA分子、DNA疫苗及应用。本发明提供的SEQ ID NO：1核酸序列在真核表达系统中能够高效转录和表达，而且具有免疫原性，表现在体液免疫和细胞免疫应答中，以此作为活性成分的核酸疫苗同样具有良好的免疫原性。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN347705379">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-COV-2病毒B.1.617.2突变株DNA疫苗及应用</strong> - 本发明涉及生物技术领域，具体而言，提供了一种编码SARS‑COV‑2病毒B.1.617.2突变株抗原的DNA分子、DNA疫苗及应用。本发明提供的SEQ ID NO：1核酸序列在真核表达系统中能够高效转录和表达，而且具有免疫原性，表现在体液免疫和细胞免疫应答中，以此作为活性成分的核酸疫苗同样具有良好的免疫原性。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN347705359">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hung Thanh Phan COVID-19 NEW SOLUTION</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU344983394">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A METHOD TO REVEAL MOTIF PATTERNS OF COVID-19 USING MULTIPLE SEQUENCE ALIGNMENT</strong> - This present invention consists of different levels of computation and work in a pipeline manner i.e., input of one will be output of another and it is sequential process. Input data given in form of nucleotide sequence (DNA) of different COVID-19 patients (1). Using these nucleotide sequence perform mutation if possible and arrange them in a sequential order (2). Arrange number of nucleotide sequences of different patients in row wise and also compute number of characters in each row. (3). Compute frequency of occurrence of character in column wise and create a matrix having 4 rows and maximum sequence length will be the column size (4). Find the character like A, T, C, and G which one has maximum score and similarly find for each column to produce a final sequence (5). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN346039750">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Moment of Excruciating Anticipation in Kyiv</strong> - As the possibility of further war with Russia looms, people in Ukraine’s capital make plans to fight or flee. - <a href="https://www.newyorker.com/news/dispatch/a-moment-of-excruciating-anticipation-in-kyiv">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Three Economic Scenarios for an Election Year</strong> - With ten months to the midterms, growth is strong but inflation is hurting the chances of Joe Biden and the Democrats. - <a href="https://www.newyorker.com/news/our-columnists/three-economic-scenarios-for-an-election-year">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Imagine a World Without Spotify</strong> - In order to support musicians you care about, you may have to give up the idea that all music should be available on demand. - <a href="https://www.newyorker.com/culture/cultural-comment/imagine-a-world-without-spotify">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia, Ukraine, and the NATO of Today</strong> - If a lot has changed since the end of the Cold War, there’s much that hasn’t. - <a href="https://www.newyorker.com/news/daily-comment/russia-ukraine-and-the-nato-of-today">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ISIS Loses Its Leader as Biden Navigates Global Crises</strong> - Hajji Abdullah is the latest jihadi leader eliminated in a U.S. raid, but the President still faces challenges in Russia, China, and Iran, as well as the pandemic. - <a href="https://www.newyorker.com/news/daily-comment/isis-loses-its-leader-as-biden-navigates-global-crises">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Nathan Chen is America’s best shot at figure skating gold</strong> -
<figure>
<img alt="" src="https://cdn.vox-
cdn.com/thumbor/xpjSARSTiAPkPIWgHRC-H8P0V84=/324x0:3924x2700/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70470461/GettyImages_1238156776.0.jpg"/>
<figcaption>
US figure skater Nathan Chen. | Valery Sharifulin/TASS via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The “Quad King” finished fifth at the 2018 Olympics but has since become almost unbeatable in international competition.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jGVak3">
The Olympic spotlight is, once again, on American skater Nathan Chen. The 22-year-old Utah native is arguably Team USA’s best shot at winning gold across the sport’s four disciplines (men’s, women’s, pairs, ice dance), and his participation in the team event is crucial to America’s chance at clinching a team medal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BRgfLj">
Figure skating is a niche sport, one that most Americans only really pay attention to during an Olympic year. Even casual viewers, though, have likely heard or seen the buzz surrounding Chen through commercials and <a href="https://www.youtube.com/watch?v=j9J1petMW6c">television promos</a> as the American athlete who might make history.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="buD01H">
In 2018, Chen was, perhaps prematurely, named a gold medal favorite in Pyeongchang, based on his rare ability to execute five different quadruple jumps. This technical arsenal made Chen a serious contender for the gold. Dubbed the “Quad King” by American sports media, he was expected to be within confident reach of a medal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CEV2H4">
At the time, however, Chen was only in his second year of senior international competition and had yet to win a World Championship title. Chen’s disastrous short program in the 2018 men’s event effectively eliminated his chances of a solo medal. He did manage a redemptive free skate without any falls — landing a record number of six quads — that catapulted him from <a href="https://www.vox.com/2018/2/16/17020274/nathan-chen-short-program-2018-olympics">17th place</a> up to fifth. All in all, it was a laudable finish for an 18-year-old fresh on the Olympic stage.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0buw76">
Over the next four years, Chen would go on to become nearly unbeatable in international competition, with the exception of a third-place finish at the 2021 Skate America competition. When he takes the ice in Beijing, he will be regarded as a seasoned competitor and a fan favorite — a three-time world champion who has achieved <a href="https://www.vox.com/videos/2018/2/13/16991336/winter-olympics-figure-skating-score-technical">some of the highest scores</a> in the sport. His technical consistency remains largely unmatched. Chen has been the unrivaled kingpin of American figure skating since 2017, often winning the US Figure Skating Championships by a comfortable margin. He has outscored Vincent Zhou and Jason Brown, his fellow skaters on the 2022 Olympic team, in national competition by 30.9 points and 37.29 points, respectively. Chen has spoken humbly about how he has scored, but this is no simple feat. In figure skating, a tenth or even a hundredth of a point can make the difference between silver and gold.
</p>
<div id="JeUXYM">
<div style="width: 100%; height: 0; padding-bottom: 56.25%;">
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w9zNmk">
Chen’s dominance in the sport is due, in large part, to his quadruple jumps. (Vox’s Alex Abad-Santos has <a href="https://www.vox.com/2018/2/15/16996602/nathan-chen-olympics-2018">an in-depth piece</a> that explores how this offers him an unusual scoring advantage.) In short, most male skaters have only one or two quads that they consistently perform in competition; the rest of their jumps are usually triples. Chen, on the other hand, is capable of packing his routine with five different quad variations. (Most elite skaters at Chen’s level compete with three to four quads.) And since the current scoring system rewards a skater significantly more points for quads than perfectly performed triples, Chen is vulnerable only under a few circumstances: if his closest competitors skate at the top of their game; if he skates poorly in both his short program and free skate (or extremely poorly in either); or if, for some unexpected reason, Chen drastically reduces the number of quads he performs. Essentially, if Chen skates as he usually does (barring any injuries), his competitive track record makes him the clear frontrunner.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6Ce93D">
Sports coverage, however, thrives on narratives of rivalry, and analyses of Chen’s gold-medal odds are no exception. Japanese skater and two-time Olympic gold medalist Yuzuru Hanyu has been depicted as Chen’s greatest rival for the gold, in spite of their mutual respect for each other. The faceoff between Hanyu, 27, and Chen, the two <a href="https://en.wikipedia.org/wiki/List_of_highest_scores_in_figure_skating">highest-scoring male skaters</a> in figure skating history, will be something of a wild card. They last competed at the 2021 World Championships, where Hanyu placed first after the short program, but took home bronze in the free skate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6WZLNC">
Hanyu has four quads in his arsenal, but has struggled with injuries and isn’t keen on packing his routines with as many quads as possible. He does, however, have plans to debut a quadruple axel at the Olympics. The quad axel is the most difficult, and therefore highest-scoring, of the quads, and the jump has not yet been attempted in international competition. (Hanyu did attempt a quad axel at the 2022 Japanese nationals, but didn’t receive full points for its execution since he landed the jump on two feet.) If Hanyu manages to land the quad axel and skate with few or no errors — a feat he has accomplished under intense pressure before — the gold medal odds could shift in his favor.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lYQKro">
There is no doubt, though, that Chen is primed to make history in Beijing. If Chen reaches the podium, he will be the first Asian American man to win a solo Olympic medal in figure skating (he already has a bronze from the 2018 team event). Identity wins aside, Chen offers a much-needed boost to Team USA’s Olympic track record; the last time an American figure skater won a solo Olympic medal was in 2010.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c33zOJ">
Female skaters — including Asian American athletes, like Michelle Kwan and Kristi Yamaguchi — have long been the recognizable face of US figure skating. American women dominated the sport throughout the 1990s: They were top contenders for the podium at World Championships, and won two Olympic golds, two silvers, and one bronze for Team USA. Their victories briefly spurred public interest in the sport, but over the following two decades, attention toward figure skating — and America’s competitive strength in the sport — <a href="https://www.vox.com/the-goods/22276736/figure-skating-olympics-winter-2022-lessons">has been on the decline</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TmNc1x">
While a handful of American male skaters were competitive throughout the 2000s and 2010s, few stand out in the public consciousness or have achieved Chen’s level of consistency throughout his career. In this regard, Chen is a unicorn of an athlete. (It helps that he seems like a <a href="https://www.gq.com/story/nathan-chen-beijing-
olympics">pretty chill guy</a>.) It’s not just his nearly superhuman ability to perform whip-fast four-revolution jumps. Gold medal or not, Chen, at 22, has already proven himself to be one of the most decorated and successful American skaters in the history of the sport.
</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amazon is raising the price of Prime despite shipping hurdles</strong> -
<figure>
<img alt="Amazon vans in front of a Walmart store." src="https://cdn.vox-
cdn.com/thumbor/QaE1dPlh0SN6hoXGRDcrzghMjvc=/304x0:5168x3648/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70469303/GettyImages_1270474743.0.jpg"/>
<figcaption>
Justin Sullivan/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Prime membership fee is increasing to $139 annually, or $15 for those who pay monthly.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uYgWJg">
Amazon is raising the price of its Prime membership program in the US, even as a top Amazon executive admitted on Thursday that the company’s shipping speeds “are not where we want them to be.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g7p3H0">
The price of an annual Prime membership in the US is increasing to $139 from $119, while the price for customers who pay on a monthly basis is rising to $14.99 a month from $12.99. Existing Prime members will see the price change on membership renewals after March 25, while the fee increase will apply to new Prime members beginning February</p></li>
</ul>
<ol start="18" type="1">
<li>The company has more than 200 million Prime members worldwide but did not announce a price increase for any other countries.
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d5K4LS">
The oldest and most popular benefit of Prime membership is the rapid shipping speed Amazon promises customers for a huge selection of products. Yet, even with pandemic-fueled shipping delays, it seems unlikely that this price increase will convince many of the people who’ve come to rely on Amazon for everything from fast delivery to streaming video to cancel their memberships. Since its launch in 2005, Prime has single-handedly <a href="https://www.vox.com/recode/2019/5/3/18511544/amazon-prime-oral-history-jeff-bezos-one-day-shipping">reshaped what consumers expect from retailers</a> in the way of merchandise selection and convenience.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KFwNXB">
The increase to the Prime membership fee is the first <a href="https://www.vox.com/2018/4/26/17287476/amazon-prime-new-price-
increase-119-99-dollars">in nearly four years</a>, which is the same interval at which Amazon has instituted its last two Prime price increases.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ILvn7s">
“We’re not where we want to be,” Amazon Chief Financial Officer Brian Olsavsky said on a call with reporters on Thursday. Olsavsky was answering my question about what seems to be regular instances of Prime-eligible products showing delivery dates as long as five, six, or seven days from the time of order. Amazon says more than 15 million items are still available for next-day delivery.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ma658x">
In recent social media posts Recode reviewed from Prime members complaining about slow delivery times, Amazon customer service reps have responded by stressing that the historical two-day Prime delivery promise should actually be measured by looking at the time between when a product is shipped from a warehouse and not when a customer places an order. These company representatives also make clear that the shipping promises are counted in business days. Yet there was a time not long ago when Amazon boasted about Sunday deliveries in the US, thanks to a special arrangement with the United States Postal Service.
</p>
<div id="5Fw566">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Hello there! Prime shipping refers to transit time, in business days, from when your order ships. There are many factors that can impact processing times, such as local availability and location. For more information: <a href="https://t.co/eno2kujnSD">https://t.co/eno2kujnSD</a>. -Teia
</p>
— Amazon Help (<span class="citation" data-cites="AmazonHelp">@AmazonHelp</span>) <a href="https://twitter.com/AmazonHelp/status/1487525367271378959?ref_src=twsrc%5Etfw">January 29, 2022</a>
</blockquote></div></li>
</ol>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VqhGQl">
Still, Olsavsky said Amazon is seeing improvements in the percentage of products it has available with faster shipping speeds, including for one-day shipping. In April of 2019, Amazon had announced that it was working to make one-day shipping the new standard for the Prime delivery program. The pandemic has delayed that ambitious goal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WVkd6m">
It’s possible the Prime price hike could provide an opening for competing delivery subscriptions from big-box competitors to attract cost-conscious shoppers. Walmart unveiled a <a href="https://www.vox.com/recode/2020/9/1/21409628/walmart-plus-benefits-free-grocery-delivery-amazon-prime-
comparison">$98-a-year membership called Walmart+</a> in September 2020, which offers free shipping and same-day delivery of groceries and other general merchandise direct from local Walmart stores, as well as fuel discounts at Walmart gas stations and prescription discounts at Walmart pharmacies. But the Walmart offering doesn’t include many of the other perks that come with Prime, such as the Prime Music and Prime Video streaming services, which now include exclusive rights to Thursday Night Football and Amazon Originals like <em>The Boys</em>, <em>The Wheel of Time</em>, <em>Sound of Metal, </em>and, soon, a new <em>Lord of the Rings</em> series.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mnwcbI">
The price increase comes as Amazon’s core e-commerce business in North America actually lost money in the holiday quarter for the first time in many years. Olsavsky told reporters and analysts that the omicron variant has once again disrupted warehouse work and led to increased labor costs. He said that the company is at times paying two or three times a normal wage for a single role — paid leave to the employee who’s out sick, plus a regular wage and overtime for a worker filling in.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bi2bCJ">
Prime has long been the <a href="https://www.vox.com/recode/2019/5/3/18511544/amazon-prime-oral-history-
jeff-bezos-one-day-shipping">engine behind Amazon’s e-commerce dominance</a>, with members shopping more frequently and spending more on Amazon than non-members do, and price-comparing on other sites less. But as <a href="https://www.vox.com/22811903/inflation-rate-2021-christmas-holidays-report-cpi">inflation results in price increases on everything</a> from homes to cars, Prime members can add another price hike to the list.
</p>
<ul>
<li><strong>How insulated glass changed architecture</strong> -
<figure>
<img alt="" src="https://cdn.vox-
cdn.com/thumbor/WibS0_SziuaHrDE7IpMf2dW4Z70=/240x0:1680x1080/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70468431/thumbchorusclean.0.jpeg"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
No pane, no gain.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e090hO">
Today, it’s easy to take big glass windows and doors for granted, whether they show up in commercial buildings or in our homes. But this use of glass is, at its core, a technological breakthrough that changed how we live and how our buildings work.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1wHJyU">
As architecture professor Thomas Leslie explains, insulated glass shaped the look of the 20th century. Big but poorly insulated glass windows went out of fashion as electricity allowed for the production of artificial light. Builders needed a new way to install windows that let in natural light, but also controlled heat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mjWNxb">
Insulated glass was that solution. As the above video shows, the invention of a branded glass — Thermopane — and its immediate competitors led to the landscape we recognize today.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jk60Rn">
Further reading:
</p>
<ul>
<li id="wnUSJq">
In <a href="https://www.jstor.org/stable/26632385?refreqid=excelsior%3A0986ff2a921f82f80d7f149d8cac0f25&amp;seq=1#metadata_info_tab_contents">this paper about the development of insulated glass</a>, Thomas Leslie explores the history of the enclosure.
</li>
<li id="v9zMkM">
Flickr groups can be a great tool for finding old ads. The <a href="https://www.flickr.com/search/?group_id=73616815%40N00&amp;view_all=1&amp;text=thermopane">“Vintage Advertising” group</a> includes some great examples of old Thermopane ads.
</li>
<li id="mvnBUD">
You can also find <a href="https://www.flickr.com/search/?group_id=73616815%40N00&amp;view_all=1&amp;text=twindow">ads for Twindow</a>.
</li>
</ul>
</li><li id="wVZPKx">
The <a href="https://www.filmpreservation.org/preserved-films/screening-room/american-look-1958">film in this video, <em>American Look</em></a>, is a 1958 look at the cutting edge of design. It’s still a gorgeous film and includes some great predictions (as well as some interesting incorrect ones).
</li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XJmSc2">
You can find this video and all of <a href="https://www.youtube.com/channel/UCLXo7UDZvByw2ixzpQCufnA"><strong>Vox’s videos on YouTube</strong></a>.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beijing Winter Olympics opening ceremony starts under cloud of COVID, rights fears</strong> - The opening ceremony was attended by President Xi Jinping.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>England coach Chris Silverwood quits after Ashes humiliation</strong> - An interim coach will be appointed ahead of next month’s three Tests in the West Indies</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cricket Australia approves first tour of Pakistan in 24 years</strong> - Australia will play three Tests - in Rawalpindi, Karachi and Lahore - three one-day internationals and a T20I during the full tour starting next month</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>U-19 World Cup final preview | Dhull and Co. look to extend India’s undisputed dominance</strong> - They face England, a team which last reached the title clash way back in 1998 when it won its sole trophy till date</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I do my job as BCCI president and don’t need to answer speculation, says Sourav Ganguly</strong> - The former India captain not just rejected the accusations thrown at him but also offered a gentle reminder to his critics</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Power sector employees up in arms against attempts to ‘privatise’ Sri Damodaram Sanjeevaiah Thermal Power Station</strong> - The main argument being advanced in favour of entrusting the O&amp;M of SDSTPS to interested companies is that its variable cost of generation is high at ₹3.14 per KWH</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra University inks MoU with IOCL</strong> - IOCL to establish three IOCL Professor Chairs and provide training to students</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Karnataka Minister justifies call for establishing third peetha of Panchamasali sect</strong> - But, Minister for Industries Murugesh Nirani clarifies that he had not attended any meeting on setting up of the third peetha of the Panchamasali Lingayat sect</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Social media needs to be made more accountable: Vaishnaw in Rajya Sabha</strong> - The IT Minister said whenever the government has taken any step to make social media accountable, the opposition has accused it of curbing the freedom of speech</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Assam villagers oppose sanctuary tag for golden langur habitat</strong> - They want the 19.85 sq. km. patch to continue as protected community forest resource</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>China joins Russia in opposing Nato expansion</strong> - Moscow and Beijing release a statement showcasing agreement on a wide range of geopolitical issues.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Putin’s Olympic trip signals warmer Russia-China ties</strong> - Russia’s president heads to the Chinese capital, Beijing, in his first visit since the Covid pandemic.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>German anger as Russia shuts international broadcaster Deutsche Welle</strong> - Germany and the EU condemn a decision to shut down Deutsche Welle’s bureau in Moscow.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Saudi-backed Iran spies found guilty in Denmark</strong> - The three men are members of an Iranian opposition Arab group.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>European oil facilities hit by cyber-attacks</strong> - Multiple oil transport and storage companies across Europe have been hacked, the BBC has confirmed.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rocket Report: Virgin Galactic kills tourism tax, New Glenn fairing test</strong> - “The US is currently not prepared to replace or augment space launch capabilities.” - <a href="https://arstechnica.com/?p=1830790">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Controversy erupts over Aussie museum’s identification of HMS Endeavour wreck</strong> - “Based on archival and archaeological evidence, I’m convinced it’s the <em>Endeavour.</em>” - <a href="https://arstechnica.com/?p=1831567">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pulsed electromagnetic energy, ultrasound “plausibly” explain Havana syndrome</strong> - Expert panel says other popular hypotheses, like mass psychogenic illness, are unlikely. - <a href="https://arstechnica.com/?p=1831639">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amazon will increase the annual price of Prime in the US</strong> - The change goes into effect February 18 for new members, March 25 for old. - <a href="https://arstechnica.com/?p=1831626">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vote on Biden’s FCC pick delayed; Sohn faces another hearing and rocky path</strong> - Sohn will be grilled again as Cantwell grants GOP’s request for a second hearing. - <a href="https://arstechnica.com/?p=1831592">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A woman was 3 months pregnant when she fell into a deep coma and woke up after about 10 months.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The woman asked the doctor about her baby.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Doctor: You had twins, a boy and a girl. They’re both fine. And, your brother named them for you.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Woman: No No No! Not my brother. He’s an idiot! What did he name the girl?
</p>
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Doctor: Denise.
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Woman: Ohh, that’s actually a nice name. What about the boy?
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Doctor: deeply sighs Denephew.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Prison_Break_31"> /u/Prison_Break_31 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/sk63la/a_woman_was_3_months_pregnant_when_she_fell_into/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/sk63la/a_woman_was_3_months_pregnant_when_she_fell_into/">[comments]</a></span></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>My sense of humor is a lot like COVID</strong> - <!-- SC_OFF -->
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Tasteless, not good for large groups, and anyone who gets it is pretty sick.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Yeetaway987"> /u/Yeetaway987 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/sk33eo/my_sense_of_humor_is_a_lot_like_covid/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/sk33eo/my_sense_of_humor_is_a_lot_like_covid/">[comments]</a></span></p>
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<li><strong>I’ve spent an hour and a half now trying to explain “sunk cost fallacy” to my son</strong> - <!-- SC_OFF -->
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He’s no nearer understanding it than when we started, and it’s giving me a serious headache.
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But if I quit now I’ll have had all this for nothing!
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Gil-Gandel"> /u/Gil-Gandel </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/sjtrvh/ive_spent_an_hour_and_a_half_now_trying_to/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/sjtrvh/ive_spent_an_hour_and_a_half_now_trying_to/">[comments]</a></span></p></li>
<li><strong>A man was having an affair with a married woman.</strong> - <!-- SC_OFF -->
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The man had a romantic evening at her place and were about to have sex. Suddenly there is a knock at the door.
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The woman tells the man “My husband is here. Collect your clothes and get out from the window.”
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The man did not have time to get dressed and he is naked outside on the road and there is a light drizzle of rain.
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At the meantime, there is a marathon going and it passes by the man. The man also starts running with those guys.
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A runner beside him asks “Do you always run naked?”
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Man replies “Yeah. I feel comfortable this way.”
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Runner “Do you always wear a condom?”
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Man “No. Only when its raining.”
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Edit: Spelling
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/zebra8910"> /u/zebra8910 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/sk4117/a_man_was_having_an_affair_with_a_married_woman/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/sk4117/a_man_was_having_an_affair_with_a_married_woman/">[comments]</a></span></p></li>
<li><strong>A man finds a girl tied up on the railway tracks..</strong> - <!-- SC_OFF -->
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He frees her and because he frees her, he gets to have sex with her. Next day, he tells his friend “Hey you know last night, I freed this girl who was tied up at the rail way tracks and she let me bang her.” The friend responds, “That’s cool man. So, did you get a blowjob?” Guy responds back, “No man! I couldn’t find her head.”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Cautionx24"> /u/Cautionx24 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/sk7zag/a_man_finds_a_girl_tied_up_on_the_railway_tracks/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/sk7zag/a_man_finds_a_girl_tied_up_on_the_railway_tracks/">[comments]</a></span></p></li>
</ul>
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