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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>SARS-CoV-2 viral RNA levels are not “viral load”</strong> -
<div>
Ct values are commonly used as proxy of SARS-CoV-2 “viral load”. Because of the (+)ssRNA nature of coronaviruses, current RT-qPCR target amplification does not distinguish replicative from transcriptional RNA. Although Ct values analyses through time, space and biological backgrounds remain informative, equating Ct with viral load may generate misleading conclusions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/5gra3/" target="_blank">SARS-CoV-2 viral RNA levels are not “viral load”</a>
</div></li>
<li><strong>University Students’ Adherence to the COVID-19-guidelines: A Qualitative Study on Facilitators and Barriers</strong> -
<div>
Objective. This study aims to explore students’ adherence and reasons behind the (non)adherence to the COVID-19-regulations within a university setting. Methods. A total of 33 students participated in on-site and online focus group interviews (k=8). Discussed topics included the general COVID-19-guidelines of the university, including keeping ≥1.5 m distance, staying at home and getting tested when having symptoms, and wearing facemasks. Additionally, education and psychosocial wellbeing in the times of COVID-19 were discussed. We also conducted online interviews with stewards (2 focus group interviews and 1 individual interview) and security/crowd control officials (1 focus group interview) to learn more about students’ (non)adherence behaviors. Results. The findings of this study show that the interviewed students were willing to adhere to the guidelines within the university buildings. They mentioned several facilitators (e.g., the infrastructure of the buildings and staff) and barriers (e.g., being together with friends and difficulties with telling others to follow the regulations) for their compliance behaviors. Some students also stated that they are not afraid of COVID-19 because they are young, while others adhered to the regulations to protect vulnerable people. Conclusion. To create a safe environment within the university and alleviate the spread of the virus, future interventions require targeting the determinants of students’ non-adherence behaviors, such as lower risk perception (e.g., being young and no perceived threat/low vulnerability) and lower self-efficacy (e.g., for keeping distance, to determine symptoms for testing/isolating and to correct others).
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/z6cg9/" target="_blank">University Students’ Adherence to the COVID-19-guidelines: A Qualitative Study on Facilitators and Barriers</a>
</div></li>
<li><strong>COVID-19 and false dichotomies — A nuanced review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection</strong> -
<div>
Background: Scientists across disciplines, policymakers, and journalists have voiced frustration at the polarization of opinions focusing on global and national responses to the coronavirus disease 2019 (COVID-19) pandemic. Herein, we address several false dichotomies that have emerged in public debates. Methods and main text: This narrative review endeavors to thoughtfully review the evidence and knowledge gaps about six COVID-19 topics commonly presented as false dichotomies: 1) Health and lives vs. economy and livelihoods, 2) Indefinite lockdown vs. unlimited reopening, 3) Symptomatic vs. asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, 4) Droplet vs. aerosol transmission of SARS-CoV-2, 5) Masks for all vs. no masking, and 6) SARS-CoV-2 reinfection vs. no reinfection. Basic concepts, nuances, and debated issues are presented for each topic. We discuss the importance of multidisciplinary integration (health, social, and physical sciences), multilayered approaches to reducing risk, harm reduction, smart masking, and context-sensitive policymaking for COVID-19 response plans. We also address the challenges in understanding the broad clinical presentation of COVID-19, the transmission of SARS-CoV-2, and the occurrence of SARS-CoV-2 reinfection. Conclusions: Our review compiles and discusses evidence in the context of a complex policy landscape with many actors and competing priorities and risks. Science, public health, and several aspects of pathogen transmission, infection, and disease are fraught with uncertainty. They exist on a spectrum of gray shades between the extremes of black and white—they are hardly binary, simple, settled, or uniform, and should not be framed as such. In light of the challenges surrounding the science-policy interface for COVID-19, we caution against black-or-white messaging, all-or-nothing guidance, and one-size-fits-all approaches. We underscore the need for culturally appropriate public health communication, science-informed tailored policies, and health journalism that reckon with shades of gray, uncertainties, local contexts, and social determinants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/k2d84/" target="_blank">COVID-19 and false dichotomies — A nuanced review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection</a>
</div></li>
<li><strong>Pan-ErbB inhibition protects from SARS-CoV-2 replication, inflammation, and injury</strong> -
<div>
Effective therapies are needed to combat emerging viruses. Seventeen candidates that rescue cells from SARS-CoV-2-induced lethality and target diverse functions emerged in a screen of 4,413 compounds. Among the hits was lapatinib, an approved inhibitor of the ErbB family of receptor tyrosine kinases. Lapatinib and other pan-ErbB inhibitors suppress replication of SARS-CoV-2 and unrelated viruses with a high barrier to resistance. ErbB4, but not lapatinib’s cancer targets ErbB1 and ErbB2, is required for SARS-CoV-2 entry and Venezuelan equine encephalitis virus infection and is a molecular target mediating lapatinib’s antiviral effect. In human lung organoids, lapatinib protects from SARS-CoV-2-induced activation of pathways implicated in acute and chronic lung injury downstream of ErbBs (p38-MAPK, MEK/ERK, and AKT/mTOR), pro-inflammatory cytokine production, and epithelial barrier injury. These findings reveal regulation of viral infection, inflammation, and tissue injury via ErbBs and propose approved candidates to counteract these effects with implications for coronaviruses and unrelated viruses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.15.444128v1" target="_blank">Pan-ErbB inhibition protects from SARS-CoV-2 replication, inflammation, and injury</a>
</div></li>
<li><strong>Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design</strong> -
<div>
The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need for highly effective vaccine candidates that are thermostable and amenable to large-scale manufacturing. Nanoparticle immunogens presenting the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein (S) in repetitive arrays are being advanced as second-generation vaccine candidates, as they feature robust manufacturing characteristics and have shown promising immunogenicity in preclinical models. Here, we used previously reported deep mutational scanning (DMS) data to guide the design of stabilized variants of the RBD. The selected mutations fill a cavity in the RBD that has been identified as a linoleic acid binding pocket. Screening of several designs led to the selection of two lead candidates that expressed at higher yields than the wild-type RBD. These stabilized RBDs possess enhanced thermal stability and resistance to aggregation, particularly when incorporated into an icosahedral nanoparticle immunogen that maintained its integrity and antigenicity for 28 days at 35-40{degrees}C, while corresponding immunogens displaying the wild-type RBD experienced aggregation and loss of antigenicity. The stabilized immunogens preserved the potent immunogenicity of the original nanoparticle immunogen, which is currently being evaluated in a Phase I/II clinical trial. Our findings may improve the scalability and stability of RBD-based coronavirus vaccines in any format and more generally highlight the utility of comprehensive DMS data in guiding vaccine design.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.15.444222v1" target="_blank">Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design</a>
</div></li>
<li><strong>Allicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome</strong> -
<div>
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic is a major health burden. Volatile garlic organosulfur compounds, such as the thiol-reactive allicin (diallyl thiosulfinate) exert strong antimicrobial activity against various respiratory pathogens. Here, we investigated the antiviral activity of allicin against SARS-CoV-2 in infected Vero E6 and Calu-3 lung cells. Allicin efficiently inhibited viral replication and infectivity in both cell lines. Proteome analyses of infected Calu-3 cells revealed a strong induction of the antiviral interferon-stimulated gene (ISG) signature (e.g. cGAS, Mx1, IFIT, IFIH, IFI16, IFI44, OAS and ISG15), pathways of vesicular transport, tight junctions (KIF5A/B/C, OSBPL2, CLTC1, ARHGAP17) and ubiquitin modification (UBE2L3/5), as well as reprogramming of host metabolism, transcription and translation. Allicin abrogated the ISG host response and reverted the host cellular pathways to levels of uninfected Calu-3 cells, confirming the antiviral and immunomodulatory activity of allicin in the host proteome. Thus, biocompatible doses of garlic could be promising for protection of lung cells against SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.15.444275v1" target="_blank">Allicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome</a>
</div></li>
<li><strong>Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition</strong> -
<div>
The emergence of novel SARS-CoV-2 lineages that are more transmissible and resistant to currently approved antibody therapies poses a considerable challenge to the clinical treatment of COVID-19. Therefore, the need for ongoing discovery efforts to identify broadly reactive monoclonal antibodies to SARS-CoV-2 is of utmost importance. Here, we report a panel of SARS-CoV-2 antibodies isolated using the LIBRA-seq technology from an individual who recovered from COVID-19. Of these antibodies, 54042-4 showed potent neutralization against authentic SARS-CoV-2 viruses, including variants of concern (VOCs). A cryo-EM structure of 54042-4 in complex with the SARS-CoV-2 spike revealed an epitope composed of residues that are highly conserved in currently circulating SARS-CoV-2 lineages. Further, 54042-4 possesses unique genetic and structural characteristics that distinguish it from other potently neutralizing SARS-CoV-2 antibodies. Together, these findings motivate 54042-4 as a lead candidate for clinical development to counteract current and future SARS-CoV-2 VOCs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.16.444004v1" target="_blank">Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition</a>
</div></li>
<li><strong>The Spike Proteins of SARS-CoV-2 B.1.617 and B.1.618 Variants Identified in India Provide Partial Resistance to Vaccine-elicited and Therapeutic Monoclonal Antibodies.</strong> -
<div>
Highly transmissible SARS-CoV-2 variants recently identified in India designated B.1.617 and B.1.618 have mutations within the spike protein that may contribute to their increased transmissibility and that could potentially result in re-infection or resistance to vaccine-elicited antibody. B.1.617 encodes a spike protein with mutations L452R, E484Q, D614G and P681R while the B.1.618 spike has mutations {Delta}145-146, E484K and D614G. We generated lentiviruses pseudotyped by the variant proteins and determined their resistance to neutralization by convalescent sera, vaccine-elicited antibodies and therapeutic monoclonal antibodies. Viruses with B.1.617 and B.1.618 spike were neutralized with a 2-5-fold decrease in titer by convalescent sera and vaccine-elicited antibodies. The E484Q and E484K versions were neutralized with a 2-4-fold decrease in titer. Virus with the B.1.617 spike protein was neutralized with a 4.7-fold decrease in titer by the Regeneron monoclonal antibody cocktail as a result of the L452R mutation. The modest neutralization resistance of the variant spike proteins to vaccine elicited antibody suggests that current vaccines will remain protective against the B.1.617 and B.1.618 variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.14.444076v1" target="_blank">The Spike Proteins of SARS-CoV-2 B.1.617 and B.1.618 Variants Identified in India Provide Partial Resistance to Vaccine-elicited and Therapeutic Monoclonal Antibodies.</a>
</div></li>
<li><strong>CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes</strong> -
<div>
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans could cause coronavirus disease 2019 (COVID-19). Since its first discovery in Dec 2019, SARS-CoV-2 has become a global pandemic and caused 3.3 million direct/indirect deaths (2021 May). Amongst the scientific community’s response to COVID-19, data sharing has emerged as an essential aspect of the combat against SARS-CoV-2. Despite the ever-growing studies about SARS-CoV-2 and COVID-19, to date, only a few databases were curated to enable access to gene expression data. Furthermore, these databases curated only a small set of data and do not provide easy access for investigators without computational skills to perform analyses. To fill this gap and advance open-access to the growing gene expression data on this deadly virus, we collected about 1,500 bulk RNA-seq datasets from publicly available resources, developed a database and visualization tool, named CovidExpress (https://stjudecab.github.io/covidexpress). This open access database will allow research investigators to examine the gene expression in various tissues, cell lines, and their response to SARS-CoV-2 under different experimental conditions, accelerating the understanding of the etiology of this disease in order to inform the drug and vaccine development. Our integrative analysis of this big dataset highlights a set of commonly regulated genes in SARS-CoV-2 infected lung and nasal tissues, including OASL that were under-studied in COVID-19 related reports. Our results also suggested a potential FURIN positive feedback loop that might explain the evolutional advantage of SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.14.444026v1" target="_blank">CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes</a>
</div></li>
<li><strong>Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants</strong> -
<div>
SARS-CoV-2 mutations may diminish vaccine-induced protective immune responses, and the durability of such responses has not been previously reported. Here, we present a comprehensive assessment of the impact of variants B.1.1.7, B.1.351, P.1, B.1.429, and B.1.526 on binding, neutralizing, and ACE2-blocking antibodies elicited by the vaccine mRNA-1273 over seven months. Cross-reactive neutralizing responses were rare after a single dose of mRNA-1273. At the peak of response to the second dose, all subjects had robust responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6 months after the primary series of mRNA-1273. Across all assays, B.1.351 had the greatest impact on antibody recognition, and B.1.1.7 the least. These data complement ongoing studies of clinical protection to inform the potential need for additional boost vaccinations.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.13.444010v1" target="_blank">Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants</a>
</div></li>
<li><strong>The first patient with COVID-19: Notes from the Trenches</strong> -
<div>
COVID-19 is a rapidly evolving situation and presently India has amongst the highest numbers of patients in the world. However, in the initial parts of the pandemic, the reaction of patients and clinicians to COVID-19 was one that was informed by being faced with a totally novel situation. This paper describes the personal experience of the first patient with COVID-19 admitted to a tertiary hospital in North India and the treating doctors. Implications of the experiences are discussed.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/v49ys/" target="_blank">The first patient with COVID-19: Notes from the Trenches</a>
</div></li>
<li><strong>Relative burdens of the COVID-19, malaria, tuberculosis and HIV/AIDS epidemics in sub-Saharan Africa</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives: COVID-19 has had considerable global impact, but in sub-Saharan Africa is one of several infectious disease priorities. Prioritization is normally guided by disease burden, but the highly age-dependent nature of COVID-19 and other infectious diseases makes comparisons challenging unless considered through metrics that incorporate life years lost and time lived in adverse health. We compared the burdens of COVID-19 and three major epidemic-causing pathogens; malaria, tuberculosis and HIV/AIDS. Design: We compared estimates of 12-month disease burdens in sub-Saharan African populations through mortality and Disability-Adjusted Life Years lost (DALYs) for COVID-19, malaria, tuberculosis and HIV/AIDS, applying known age-related mortality to UN estimates of age structure. We further compared exacerbations disease burden predicted from the COVID-19 public health response. Data was derived from public sources, predicted exacerbations from those published by international agencies. Main outcome measures: Mortality and DALYs lost Results: For sub-Saharan African populations north of South Africa, recorded COVID-19 DALYs lost in 2020 was 3.7%, 2.3% and 2.4% of those estimated for tuberculosis, HIV/AIDS and malaria respectively. The predicted exacerbations alone of these comparator diseases were greater than the estimated COVID-19 burden. Including South Africa and Lesotho, COVID-19 DALYs lost were &lt;12% of those for comparator diseases and dominated by them in all age groups below 65 years. Conclusions: The analysis suggests a relatively low impact from COVID-19. While all four epidemics continue, concentration on COVID-19 runs a high risk of increasing the overall health burden, further increasing global inequities in health and life expectancy.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.27.21254483v3" target="_blank">Relative burdens of the COVID-19, malaria, tuberculosis and HIV/AIDS epidemics in sub-Saharan Africa</a>
</div></li>
<li><strong>Global seroprevalence of SARS-CoV-2 antibodies: a systematic review and meta-analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background Many studies report the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. We aimed to synthesize seroprevalence data to better estimate the level and distribution of SARS-CoV-2 infection, identify high-risk groups, and inform public health decision making. Methods In this systematic review and meta-analysis, we searched publication databases, preprint servers, and grey literature sources for seroepidemiological study reports, from January 1, 2020 to December 31, 2020. We included studies that reported a sample size, study date, location, and seroprevalence estimate. We corrected estimates for imperfect test accuracy with Bayesian measurement error models, conducted meta-analysis to identify demographic differences in the prevalence of SARS-CoV-2 antibodies, and meta-regression to identify study-level factors associated with seroprevalence. We compared region-specific seroprevalence data to confirmed cumulative incidence. PROSPERO: CRD42020183634. Results We identified 968 seroprevalence studies including 9.3 million participants in 74 countries. There were 472 studies (49%) at low or moderate risk of bias. Seroprevalence was low in the general population (median 4.5%, IQR 2.4-8.4%); however, it varied widely in specific populations from low (0.6% perinatal) to high (59% persons in assisted living and long-term care facilities). Median seroprevalence also varied by Global Burden of Disease region, from 0.6 % in Southeast Asia, East Asia and Oceania to 19.5% in Sub-Saharan Africa (p&lt;0.001). National studies had lower seroprevalence estimates than regional and local studies (p&lt;0.001). Compared to Caucasian persons, Black persons (prevalence ratio [RR] 3.37, 95% CI 2.64-4.29), Asian persons (RR 2.47, 95% CI 1.96-3.11), Indigenous persons (RR 5.47, 95% CI 1.01-32.6), and multi-racial persons (RR 1.89, 95% CI 1.60-2.24) were more likely to be seropositive. Seroprevalence was higher among people ages 18-64 compared to 65 and over (RR 1.27, 95% CI 1.11-1.45). Health care workers in contact with infected persons had a 2.10 times (95% CI 1.28-3.44) higher risk compared to health care workers without known contact. There was no difference in seroprevalence between sex groups. Seroprevalence estimates from national studies were a median 18.1 times (IQR 5.9-38.7) higher than the corresponding SARS-CoV-2 cumulative incidence, but there was large variation between Global Burden of Disease regions from 6.7 in South Asia to 602.5 in Sub-Saharan Africa. Notable methodological limitations of serosurveys included absent reporting of test information, no statistical correction for demographics or test sensitivity and specificity, use of non-probability sampling and use of non-representative sample frames. Discussion Most of the population remains susceptible to SARS-CoV-2 infection. Public health measures must be improved to protect disproportionately affected groups, including racial and ethnic minorities, until vaccine-derived herd immunity is achieved. Improvements in serosurvey design and reporting are needed for ongoing monitoring of infection prevalence and the pandemic response.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.17.20233460v3" target="_blank">Global seroprevalence of SARS-CoV-2 antibodies: a systematic review and meta-analysis</a>
</div></li>
<li><strong>Toxoplasmosis: An important risk factor for acquiring SARS-CoV-2 infection and a severe course of Covid-19 disease</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background Latent toxoplasmosis, i.e. a lifelong infection with the protozoan parasite Toxoplasma gondii, affects about a third of human population worldwide. In the past ten years, numerous studies had shown that infected subjects have a significantly higher incidence of mental and physical health problems and are more prone to exhibiting the adverse effects of various diseases. Methods A cross-sectional internet study was performed on a population of 4,499 Toxoplasma-free and 786 Toxoplasma-infected subjects and looked for factors which positively or negatively affect the risk of SARS-CoV-2 infection and likelihood of a severe course of Covid-19. Findings Logistic regression and partial Kendall correlation controlled for sex, age, and size of the place of residence showed that latent toxoplasmosis had the strongest effect on the risk of infection (OR = 1.50) before sport (OR = 1.30), and borreliosis (1.27). It also had the strongest effect on the risk of severe course of infection (Tau = 0.146), before autoimmunity, immunodeficiency, male sex, keeping a cat, being overweight, borreliosis, higher age, or chronic obstructive pulmonary disease. Toxoplasmosis augmented the adverse effects of other risk factors but was not the proximal cause of the effect of cat keeping (in the form of higher likelihood of Covid infection and higher severity of the course of infection), which was observed especially in a subset of Toxoplasma-infected subjects (Tau = 0.153). Effects of keeping a cat were detected only in subjects from multi-member families, suggesting that a cat could a vector for the transmission of SARS-CoV-2 within a family. Interpretations Toxoplasmosis is currently not considered a risk factor for Covid-19 and Toxoplasma-infected subjects are neither informed about their higher risks nor prioritised in vaccination programs. Because toxoplasmosis affects a large segment of the human population, its impact on Covid-19-associated effects on public health could be considerable.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.05.15.21257257v1" target="_blank">Toxoplasmosis: An important risk factor for acquiring SARS-CoV-2 infection and a severe course of Covid-19 disease</a>
</div></li>
<li><strong>Missing data matters in participatory syndromic surveillance systems: comparative evaluation of missing data methods when estimating disease burden</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Introduction Traditional surveillance methods have been enhanced by the emergence of online participatory syndromic surveillance systems that collect health-related digital data. These systems have many applications including tracking weekly prevalence of Influenza-Like Illness (ILI), predicting probable infection of Coronavirus 2019 (COVID-19), and determining risk factors of ILI and COVID-19. However, not every volunteer consistently completes surveys. In this study, we assess how different missing data methods affect estimates of ILI burden using data from FluTracking, a participatory surveillance system in Australia. Methods We estimate the incidence rate, the incidence proportion, and weekly prevalence using five missing data methods: available case, complete case, assume missing is non-ILI, multiple imputation (MI), and delta (δ) MI, which is a flexible and transparent method to impute missing data under Missing Not at Random (MNAR) assumptions. We evaluate these methods using simulated and FluTracking data. Results Our simulations show that the optimal missing data method depends on the measure of ILI burden and the underlying missingness model. Of note, the δ-MI method provides estimates of ILI burden that are similar to the true parameter under MNAR models. When we apply these methods to FluTracking, we find that the δ-MI method accurately predicted complete, end of season weekly prevalence estimates from real-time data. Conclusion Missing data is an important problem in participatory surveillance systems. Here, we show that accounting for missingness using statistical approaches leads to different inferences from the data.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.05.11.21256420v1" target="_blank">Missing data matters in participatory syndromic surveillance systems: comparative evaluation of missing data methods when estimating disease burden</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 3 Randomized, Double-Blind Placebo Controlled, Multi-regional Trial to Evaluate the Efficacy and Safety of GT0918 for the Treatment of Mild to Moderate COVID-19 Male Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: GT0918 tablets or placebo<br/><b>Sponsor</b>:   Suzhou Kintor Pharmaceutical Inc,<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recombinant Hyperimmune Polyclonal Antibody (GIGA-2050) in COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: GIGA-2050<br/><b>Sponsor</b>:   GigaGen, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Role of High Dose Co-trimoxazole in Severe Covid-19 Patients</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: Co-trimoxazole;   Drug: Placebo<br/><b>Sponsor</b>:   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Vitamin D Supplementation on COVID-19 Recovery</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Vit-D 0.2 MG/ML Oral Solution [Calcidol];   Drug: Physiological Irrigating Solution<br/><b>Sponsors</b>:   University of Monastir;   Loussaief Chawki;   Nissaf Ben Alaya;   Cyrine Ben Nasrallah;   Manel Ben Belgacem;   Hela Abroug;   Imen Zemni;   Manel Ben fredj;   Wafa Dhouib<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Clinical Trial to Evaluate the Recombinant SARS-CoV-2 Vaccine (CHO Cell) for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: low-dose Recombinant SARS-CoV-2 Vaccine (CHO cell);   Biological: high-dose Recombinant SARS-CoV-2 Vaccine (CHO cell);   Biological: placebo<br/><b>Sponsors</b>:   National Vaccine and Serum Institute, China;   Lanzhou Institute of Biological Products Co., Ltd;   Beijing Zhong Sheng Heng Yi Pharmaceutical Technology Co., Ltd.;   Zhengzhou University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Safety and Effect of STC3141 Continuous Infusion in Subjects With Severe Corona Virus Disease 2019（COVID-19）Pneumonia</strong> - <b>Condition</b>:   Severe COVID-19 Pneumonia<br/><b>Intervention</b>:   Drug: STC3141<br/><b>Sponsors</b>:   Grand Medical Pty Ltd.;   Trium Clinical Consulting<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>tDCS for Post COVID-19 Fatigue</strong> - <b>Condition</b>:   Post Covid-19 Patients<br/><b>Intervention</b>:   Device: Transcranial Direct Current Stimulation<br/><b>Sponsor</b>:   Thorsten Rudroff<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 2 Study of APX-115 in Hospitalized Patients With Confirmed Mild to Moderate COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: APX-115;   Drug: Placebo<br/><b>Sponsors</b>:   Aptabio Therapeutics, Inc.;   Covance<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leveraging CHWs to Improve COVID-19 Testing and Mitigation Among CJIs Accessing a Corrections-focused CBO</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Behavioral: Onsite Point-of-care<br/><b>Sponsors</b>:   Montefiore Medical Center;   The Fortune Society;   University of Bristol<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Breathing Effort in Covid-19 Pneumonia: Effects of Positive Pressure, Inspired Oxygen Fraction and Decubitus</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Device: Esophageal catheter<br/><b>Sponsor</b>:   San Luigi Gonzaga Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Convalescent Plasma as Adjunct Therapy for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Convalescent plasma treatment<br/><b>Sponsors</b>:   National Institute of Health Research and Development, Ministry of Health Republic of Indonesia;   Indonesian Red Cross;   Eijkman Institute for Molecular Biology<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Selenium (as Selenious Acid);   Other: Placebo<br/><b>Sponsors</b>:   CHRISTUS Health;   Pharco Pharmaceuticals<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety, Tolerability and PK of Ensovibep (MP0420 - a New Candidate With Potential for Treatment of COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Ensovibep;   Drug: Placebo<br/><b>Sponsor</b>:   Molecular Partners AG<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Global Phase III Clinical Trial of Recombinant COVID-19 Vaccine (Sf9 Cells)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 vaccine (Sf9 cells);   Other: Placebo control<br/><b>Sponsors</b>:   Jiangsu Province Centers for Disease Control and Prevention;   WestVac Biopharma Co., Ltd.;   West China Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>#SafeHandsSafeHearts: An eHealth Intervention for COVID-19 Prevention and Support</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Behavioral: eHealth for Covid-19 prevention and support<br/><b>Sponsor</b>:   University of Toronto<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A SCID mouse-human lung xenograft model of SARS-CoV-2 infection</strong> - SARS-CoV-2 infection, which is responsible for the current COVID-19 pandemic, can cause life-threatening pneumonia, respiratory failure and even death. Characterizing SARS-CoV-2 pathogenesis in primary human target cells and tissues is crucial for developing vaccines and therapeutics. However, given the limited access to clinical samples from COVID-19 patients, there is a pressing need for in vitro/in vivo models to investigate authentic SARS-CoV-2 infection in primary human lung cells or…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm</strong> - Cytokine storm (CS), an excessive release of proinflammatory cytokines upon overactivation of the innate immune system, came recently to the focus of interest because of its role in the life-threatening consequences of certain immune therapies and viral diseases, including CAR-T cell therapy and Covid-19. Because complement activation with subsequent anaphylatoxin release is in the core of innate immune stimulation, studying the relationship between complement activation and cytokine release in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration</strong> - The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global health and has posed significant challenges for the treatment of severely ill COVID-19 patients. Several studies have reported that cytokine storms are an important cause of disease deterioration and death in COVID-19 patients. Consequently, it is important to understand the specific pathophysiological processes underlying how…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro</strong> - Coronavirus disease 2019 (COVID-19) has caused serious public health, social, and economic damage worldwide and effective drugs that prevent or cure COVID-19 are urgently needed. Approved drugs including Hydroxychloroquine, Remdesivir or Interferon were reported to inhibit the infection or propagation of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), however, their clinical efficacies have not yet been well demonstrated. To identify drugs with higher antiviral potency, we…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Psychological Predictors of Precautionary Behaviors in Response to COVID-19: A Structural Model</strong> - The first lines of defense during an epidemic are behavioral interventions, including stay-at-home measures or precautionary health training, aimed at reducing contact and disease transmission. Examining the psychosocial variables that may lead to greater adoption of such precautionary behaviors is critical. The present study examines predictors of precautionary practices against coronavirus disease 2019 (COVID-19) in 709 Mexican participants from 24 states. The study was conducted via online…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Profiling Ribonucleotide and Deoxyribonucleotide Pools Perturbed by Remdesivir in Human Bronchial Epithelial Cells</strong> - Remdesivir (RDV) has generated much anticipation for its moderate effect in treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the unsatisfactory survival rates of hospitalized patients limit its application to the treatment of coronavirus disease 2019 (COVID-19). Therefore, improvement of antiviral efficacy of RDV is urgently needed. As a typical nucleotide analog, the activation of RDV to bioactive triphosphate will affect the biosynthesis of endogenous…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An insight into the inhibitory mechanism of phytochemicals and FDA-approved drugs on the ACE2-Spike complex of SARS-CoV-2 using computational methods</strong> - The S-glycoprotein (Spike) of the SARS-CoV-2 forms a complex with the human transmembrane protein angiotensin-converting enzyme 2 (ACE2) during infection. It forms the first line of contact with the human cell. The FDA-approved drugs and phytochemicals from Indian medicinal plants were explored. Molecular docking and simulations of these molecules targeting the ACE2-Spike complex were performed. Rutin DAB10 and Swertiapuniside were obtained as the top-scored drugs as per the docking protocol….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of SARS-CoV-2 reproduction using Boswellia carterii: A theoretical study</strong> - This study investigated the possibility of inhibition of the SARS-CoV-2 virus using the compounds alpha-Boswellic acid (ABA) and beta-Boswellic acid (BBA) which are active components in the well-known natural product Boswellia carterii (BC). The SARS-CoV-2 virus reproduces in the body by linking its spike with the cell receptor. At the same time, a pH range (4.5-6) of the cell’s lysosomes is considered as a perfect environment to release RNA in the cell cytoplasm. In view of these, docking…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protein kinase CK2: a potential therapeutic target for diverse human diseases</strong> - CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other well-known functions of CK2 are in human infections; in particular, several viruses exploit host cell CK2 for their life cycle. Very recently, also SARS-CoV-2, the virus responsible for the COVID-19 pandemic,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In vitro activity of human recombinant alpha-2b interferon against SARS-CoV-2 virus</strong> - CONCLUSION: Medications for intranasal use based on IFN-α2b have high antiviral activity and are promising drugs for in vivo study in terms of prevention and treatment of COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS CoV2 infection and long COVID</strong> - COVID-19 can present with lymphopenia and extraordinary complex multi-organ pathologies that can trigger long-term sequela. Given that inflammasome products, like caspase-1,play a role inthe pathophysiology of a number of co-morbid conditions,we investigated caspases across the spectrum of COVID-19 disease.We assessed transcriptional states of multiple caspases and using flow cytometry, theexpression ofactive caspase-1 in blood cells from COVID-19 patients in acute and convalescent stages of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice</strong> - BACKGROUND: An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2) pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection and recapitulate lung disease like those seen in humans. The angiotensin-converting enzyme 2 (ACE2) is a functional receptor for SARS-CoV-2, but mice are resistant to the infection because their ACE2 is incompatible with the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein .</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PdCl(2)-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor</strong> - While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfonyl/aminocarboxamide moiety to the C-3 benzene ring attached to the isocoumarin framework. This new class of isocoumarins were synthesized via a PdCl(2)-catalyzed construction of the 4-allyl substituted 3-aryl isocoumarin ring starting from the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19</strong> - Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans. Despite several emerging vaccines, there remains no verifiable therapeutic targeted specifically to the virus. Here we present a highly effective siRNA therapeutic against SARS-CoV-2 infection using a novel lipid nanoparticle delivery system. Multiple small-interfering RNAs (siRNAs) targeting highly conserved regions of the SARS-CoV-2 virus were screened and three…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structural Basis for the Understanding of Entry Inhibitors Against SARS Viruses</strong> - Outbreaks due to Severe Acute Respiratory Syndrome-Corona virus 2 (SARS-CoV-2) initiated in Wuhan city, China, in December 2019 which continued to spread internationally, posing a pandemic threat as declared by WHO and as of March 10, 2021, confirmed cases reached 118 million along with 2.6 million deaths worldwide. In the absence of specific antiviral medication, symptomatic treatment and physical isolation remain the options to control the contagion. The recent clinical trials on antiviral…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295937">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A COMPREHENSIVE DISINFECTION SYSTEM DURING PANDEMIC FOR PERSONAL ITEMS AND PROTECTIVE EQUIPMENT (PPE) TO SAFEGUARD PEOPLE</strong> - The current Covid-19 pandemic has led to an enormous demand for gadgets / objects for personal protection. To prevent the spread of virus, it is important to disinfect commonly touched objects. One of the ways suggested is to use a personal UV-C disinfecting box that is “efficient and effective in deactivating the COVID-19 virus. The present model has implemented the use of a UV transparent material (fused silica quartz glass tubes) as the medium of support for the objects to be disinfected to increase the effectiveness of disinfection without compromising the load bearing capacity. Aluminum foil, a UV reflecting material, was used as the inner lining of the box for effective utilization of the UVC light emitted by the UVC lamps. Care has been taken to prevent leakage of UVC radiation out of the system. COVID-19 virus can be inactivated in 5 minutes by UVC irradiation in this disinfection box - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN322882412">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UBIQUITOUS COMPUTING SYSTEM FOR MENTAL HEALTH MONITORING OF PERSON DURING THE PANDEMIC OF COVID-19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295498">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USE OF IMINOSUGAR COMPOUND IN PREPARATION OF ANTI-SARS-COV-2 VIRUS DRUG</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU322897928">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>逆转录酶突变体及其应用</strong> - 本发明提供一种MMLV逆转录酶突变体，在野生型MMLV逆转录酶氨基酸序列（如SEQ ID No.1序列所示）中进行七个氨基酸位点的突变，氨基酸突变位点为：R205H；V288T；L304K；G525D；S526D；E531G；E574G。该突变体可以降低MMLV逆转录酶对Taq DNA聚合酶的抑制作用，大大提高了一步法RT‑qPCR的灵敏度。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN323494119">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU321590214">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>用于检测新型冠状病毒的试纸和试剂盒</strong> - 本发明涉及生物技术和免疫检测技术领域，具体涉及一种用于检测新型冠状病毒的试纸和试剂盒。所述试纸或试剂盒含有抗体1和/或抗体2，所述抗体1的重、轻链可变区的氨基酸序列分别如SEQ ID NO:1‑2所示，所述抗体2的重、轻链可变区的氨基酸序列分别如SEQ ID NO:3‑4所示。本发明对于大批量的新型冠状病毒样本，包括新型冠状病毒突变（英国、南非）与非突变株的人血清、鼻咽拭子等样本的检测有普遍检测意义，避免突变株的漏检。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN322953478">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fahrgastleitsystem und Verfahren zum Leiten von Fahrgästen</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Die Erfindung betrifft ein Fahrgastleitsystem zum Leiten von mit einem Fahrzeug (1) mit wenigstens zwei Türen (2.L, 2.R) transportieren Fahrgästen (3), mit wenigstens einem Sensor (4) zur Überwachung der Fahrgäste (3), wenigstens einem Anzeigemittel (5) zur Ausgabe von Leitinformationen, wenigstens einem Aktor zum Öffnen oder Verriegeln einer Tür (2.L, 2.R) und wenigstens einer Recheneinheit (7). Das erfindungsgemäße Fahrgastleitsystem ist dadurch gekennzeichnet, dass die Recheneinheit (7) dazu eingerichtet ist durch Auswertung vom wenigstens einen Sensor (4) erzeugter Sensordaten zu erkennen an welcher Tür (2.L, 2.R) des Fahrzeugs (1) Fahrgäste (3) ein- und/oder aussteigen möchten und wenigstens eine Tür (2.L, 2.R) für einen Ausstieg festzulegen und/oder wenigstens eine Tür (2.L, 2.R) für einen Einstieg festzulegen, sodass eine Anzahl an Begegnungen von sich durch das Fahrzeug (1) bewegender Fahrgäste (3) und/oder aus dem Fahrzeug (1) aussteigenden und/oder in das Fahrzeug (1) einsteigenden Fahrgästen (3) minimiert wird.</p></li>
</ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE323289145">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vorrichtung zum Desinfizieren, der Körperpflege oder dergleichen</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Vorrichtung zum Desinfizieren, der Körperpflege oder dergleichen mittels einer flüssigen oder cremigen Substanz (20), dadurch gekennzeichnet, dass die Vorrichtung mit einem elektrisch betriebenen Erinnerungs-Modul und einem Vorratsbehälter (10) für die Substanz (20) versehen ist, die Substanz (20) in dosierter Menge zur Ausgabeöffnung (9) gefördert wird und die Vorrichtung dazu geeignet ist, am Körper oder der Kleidung einer Person getragen zu werden.</p></li>
</ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE323289850">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gebrauchter Schnellteststreifen als Probenmaterial für eine Nachtestung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Die Erfindung betrifft ein Verfahren zur laborbasierten Überprüfung und/oder weiteren Ausdifferenzierung einer im Schnelltestverfahren erhaltenen Diagnose einer Infektionskrankheit, wobei im Rahmen des Schnelltestverfahrens eine flüssige Patientenprobe auf ein Objekt aus einem porösen Material aufgetragen wird und wobei dieses Objekt nach Trocknung der flüssigen Patientenprobe an das diagnostische Labor übermittelt wird. Im Labor werden dann die eingetrockneten Probenreste aus dem porösen Material ausgelöst und analysiert.</p></li>
</ul>
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<li><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE323289151">link</a></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Rise of the Thielists</strong> - Has the Republican Party found its post-Trump ideology? - <a href="https://www.newyorker.com/news/annals-of-populism/the-rise-of-the-thielists">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Somebody Should Tell Kevin McCarthy That Trump Is Still Lying About the 2020 Election</strong> - What the House Minority Leader’s role in ousting Liz Cheney tells us about the troubled future of the Republic. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/somebody-should-tell-kevin-mccarthy-that-trump-is-still-lying-about-the-2020-election">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why It’s So Important That Twelve-Year-Olds Can Now Get a COVID-19 Vaccine</strong> - We are in a pandemic from which, as much as one might wish it, children have never been exempt. - <a href="https://www.newyorker.com/news/daily-comment/why-its-so-important-that-twelve-year-olds-can-now-get-a-covid-19-vaccine">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Japan’s Olympic-Sized Problem</strong> - The government’s inept response to the coronavirus pandemic has led to widespread discontent about hosting the Games. - <a href="https://www.newyorker.com/culture/cultural-comment/japans-olympic-sized-problem">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Saying Her Name</strong> - Remains that were found to be those of a Black teen who was killed by Philadelphia police in 1985 were treated as an anthropological specimen. How was her identity known and then forgotten? - <a href="https://www.newyorker.com/news/essay/saying-her-name">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>What we owe and are owed</strong> -
<figure>
<img alt="An illustration shows a man looking in the mirror at another version of himself, like a funhouse mirror." src="https://cdn.vox-cdn.com/thumbor/RcumTtCXadnqz4i7K-J_e_IXOWU=/407x0:2847x1830/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69265595/Fairness_Family_Final_Revised.0.jpg"/>
<figcaption>
Carlos Basabe for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Kiese Laymon on Black revision, repayment, and renewal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HV97af">
</p>
<div class="c-float-left">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/YYgW4HsU995yniG4Y5QuEoQvF0Y=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/21899595/VOX_The_Highlight_Box_Logo_Horizontal.png"/>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U5gRuI">
Part of <a href="https://www.vox.com/the-highlight/22424892/the-fairness-issue">The Fairness Issue</a> of <a href="https://www.vox.com/the-highlight"><strong>The Highlight</strong></a>, our home for ambitious stories that explain our world.
</p>
<hr class="p-entry-hr" id="SRZ1UZ"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ArJgD9">
Two days after an officer shot Ma’Khia Bryant in the back, and one day after an officer shot Andrew Brown in the back of the head, I asked my friend, Ray Gunn, if he was tired of talking to white folks about Black death. Gunn told me he didn’t understand my question.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uQclY0">
I repeated it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ta7XCv">
Gunn asked if I was getting paid for these conversations I was having with white Americans about Black death. I told him sometimes. He asked me why I would ever talk to white folks about Black death if I wasn’t getting paid.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eF9IB7">
“You know,” I told him, “like on social media …”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g6V5yQ">
Gunn shook his head.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3gGaE4">
“Or sometimes, you know, folks call you because they …”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EcnsAA">
Gunn sucked his teeth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yHWM9f">
“I mean, I’m a teacher and you know, like …”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Io1vuv">
Gunn looked lightweight disgusted.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sy9Evt">
He reminded me that he was a teacher too. “But that,” he said, “that’s not Black teacher work. That’s white family work.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uO49QJ">
Gunn told me he hadn’t had an actual conversation with a white person in 14 years, not out of protest but because there just weren’t any white folks at his job, in his house, at his church, on his social media, or in his phone. “Now, if the check was right,” he said, “I’d be a grinning, hustling-ass race whisperer. I’d be talking to everything white. Rice. Milk. Pillows.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R5pVYa">
I fell out laughing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ljSerc">
Gunn and I met in college in Jackson, Mississippi, 28 years ago. I was a first-year student from Jackson and Gunn was a super-senior from Winona by way of Chicago. The first day I met Gunn, he was posted up in the quad, setting up a picnic for his partner, V.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XdHENz">
Later that night, during our first conversation, he taught me how to make sure the ironed quilt you set out for your partner smelled like their second-favorite scent. “That means you gotta ask them what they favorite scents are,” he told me. “If the quilt ain’t ironed and smelling right, wash it and iron it again. Don’t use starch though, unless that’s her second-favorite smell. But you gotta ask.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DNjMGk">
Gunn knew he was talking about love.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NSNqpL">
I thought he was talking about “revision,” a word our professors and high school teachers believed necessitated us reducing all of our Black rhetorical abundance into meager-ass absolutes. In my own sloppy work, on and off the page, I was beginning to understand “revision” as a dynamic practice of revisitation, premised on ethically reimagining the ingredients, scope, and primary audience of one’s initial vision. Revision required witnessing and testifying. Witnessing and testifying required rigorous attempts at remembering and imagining. If revision was not God, revision was everything every God ever asked of believers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qsFEQw">
In subsequent months, Gunn and I became boys, coworkers, cousins, forever family. When we weren’t together, we talked about “we” and “us” far more than we talked about “I.” We wrote En Vogue fan fiction. We memorized every word of <em>Menace 2 Society</em> and every syllable of <em>Ready to Die</em>. We invented words that should already have existed and new definitions for words as old as American exceptionalism.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g76oWy">
We lived together in a tiny apartment on Capitol Street. We donated plasma for money right off of Fortification. We worked as porters on State Street. We stole white people’s food when there was white people’s food to be stolen. We borrowed massive cereal dispensers filled with Lucky Charms out of our college cafeteria because we were tired of Magic Stars. We jacked light bread off of bread trucks on the Reservoir. We dined, dashed, and left a tip at every Denny’s in central Mississippi. We used Gunn’s food stamps to get scallops and the good ramen to celebrate his little sister moving down to Mississippi.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="URcBWX">
We were poor. We were happy. We were not happy about being poor. But neither of us longed to be rich. We longed for healthy choices, second chances, and good love.
</p>
<div class="c-float-right c-float-hang">
<aside id="pAwaGq">
<q>Gunn asked if I was getting paid for these conversations I was having with white Americans about Black death. </q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TScnS1">
Then, after getting kicked out of our college for the theft of white folks’ food — sike! I mean white folks’ library books — I left Mississippi for Ohio, Indiana, and eventually New York.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MJUKo2">
When I returned to Mississippi 20 years later, even though my job was in a much more monied, neo-Confederate part of the state, I looked forward to living an hour from Gunn, who now worked as a teacher in a detention center for kids awaiting sentencing. I couldn’t wait to regularly hear the wavy inflections in Gunn’s voice when he did the opposite of humblebrag about his students and his own children’s grades.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ffDjOm">
I wanted to act as if nothing had changed in our relationship since we first saw each other as young men. I wanted Gunn to forget the summer of 2010 when he asked if he could bring his daughter up to college where I taught in New York. We hadn’t seen each other in six years. I agreed to take Gunn and his daughter on a tour of campus and then to the South Bronx, home of Gunn’s favorite emcee.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mXylW9">
I ended up lying about an emergency when they got to town because I didn’t want Gunn to see that I’d gained more than 120 pounds since we’d last seen each other. I didn’t want Gunn’s daughter, my goddaughter, to look at me with disgust. I didn’t want to be reminded of what I’d allowed my insides to become, nor the heart meat I’d become addicted to eating.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UAzgKD">
So I chose to harm all three of us. I lied, and I ran from my goddaughter and the one person on Earth I literally had no reason to run from.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JBTnGg">
Gunn told me he understood what I was saying because he’d lied and run from me, too. “We ain’t young. We ain’t even middle-aged,” he said. “We just straight-up old and ain’t no models of how to be straight-up old and Black and lonely. I lied to you so many times because I was ashamed. We here now.”
</p>
<hr class="p-entry-hr" id="T56EGH"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eQmebJ">
I can’t write about Ray Gunn without thinking about fairness and repair. In my laziness, I’ve conflated repair and restoration, just as I’ve lazily conflated pain with trauma, pleasure with desire, progress with liberation, honesty with truth, and fairness with equity. Restoration and repair are something we are worthy of in life and death, in relationships and solo, but they are not the same word.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xz7QfK">
Being a Black Mississippian means you will spend a lifetime repairing wounds created by the worst of white Mississippians in hopes of some kind of economic or moral renewal. This is not fair, nor is it fair that we are expected to make Black abundance out of that repair. This, however, is a part of our lineage.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IhE5wN">
The white family in America appears to have a lineage as well. The metastasized, excused unwellness in white families, monied and poor, is responsible for anti-Black terror happening in this nation’s schools, prisons, hospitals, neighborhoods, and banks. This is the work of folks who despise revision nearly as much as they despise themselves. Abolish police, bullets, missiles, and prisons all we want (and some of us truly want!), and most white American families in the US will do everything possible to make more. And in some ways, that’s their business. Cleaning up the messes that seep from these families, we’ve been taught, is what Black folk in this nation do well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7uO0Gg">
But I don’t want us to clean up the messes of white families. I want them to stop creating and pushing public policy that encourages us to die prematurely. I want them to pay my Grandmama what she is owed for a lifetime of literally, figuratively, and spiritually cleaning up their messes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1qgUHM">
We have far too many messes of our own. At my worst, I have run away from our lineage of repair and renewal when I’ve harmed folks I loved. Every time we run away from an abusive mess, a negligent mess, a lethal mess we helped create, we leave something essential for someone targeted for premature death to clean up. That is humiliation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IqupJs">
That is not fair.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lvvhdo">
Family can help us repair. Family, chosen and by birth, can also significantly aid in helping those who eat our suffering effectively wipe us off the face of the Earth. Repair what you helped break, my Grandmama taught me. Restore what responsibly loved you, I learned from Gunn. And revise, revise, revise with your family and friends. Collective freedom is impossible without interpersonal repair.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NabwHh">
I’d hoped this piece could be an extended exploration of the paradoxical economic dimensions of Black friendship during the pandemic. I wanted this piece to open, fold, and crumple the tired ways we talk about revision in this nation. I wanted to write about Gunn’s relationship to the state as a Black man who loves Black people, and a Black man who has found work in a detention center for mostly Black and Mexican young people.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o2BqYV">
But before I could write that, Gunn and I needed to talk with each other about what repair and renewal mean in our middle-age relationships with each other, with the dead, with the Earth. We have to be as concerned with the question of what we’re owed as we are with the question of what we owe us. I suspect, with rigorous, tender exploration, we will find that the answer to both of those questions is everything.
</p>
<hr class="p-entry-hr" id="XMKS1h"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bHtvxr">
One morning in the spring of 1995, I woke up to this strange, nasally voice coming from the bathroom of the apartment Gunn and I shared. The voice was overenunciating the “or” sound in “elevatOR.” The bathroom door was cracked and Gunn was in the mirror, not simply practicing talking “proper,” but also practicing verbally and vocally becoming a Black man he imagined white folks might fairly compensate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="50pNgf">
“Nigga,” I remember saying to him through the door. “What are you doing?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e2Uhhf">
“Trying to get this money,” he said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YdEbcm">
During our most recent conversation, I asked Gunn if he remembers that day in 1995. After some uncomfortable silence, Gunn answered me. And we talked. And we listened. And we were honest about what we need for repair and what we might be incapable of sharing or accepting in this piece. Before hanging up, Gunn reiterated that Black people, especially poor Black people, need checks for the checks we’ve been shorted since we were brought here. Until those checks are issued, Gunn says again, he has nothing to say to white folks about the failings of white folks when he himself has failed so many Black folks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eBSupr">
I get it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3CKzs1">
Near the end of my conversation with Gunn, he answered the goofy question, “Do you have hope in America?” with the only appropriate answer that should ever be given to that trite-ass question.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DRt9L9">
“I have faith in us.”
</p>
<div class="c-float-right c-float-hang">
<aside id="gbFjnb">
<q>Black people, especially poor Black people, need checks for the checks we’ve been shorted since we were brought here</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Sf4T0g">
When my editor asked me if I could write about “fairness” after the George Floyd verdict, I knew there was nothing new I could say to white Americans about their investments in Black suffering. It wasn’t only that it had all been said, made, and written; it had all been said, made, and written by the greatest sayers, makers, and writers in history. So I started over, and I scrapped the traditional fetishizing portals of entry into anti-racism.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cIpCBQ">
I decided I’d rather write to us and for us about the paradoxes of revision, restoration, and repair in our friendships. Instead of explaining something that has already been explained and making a spectacle of Black death, I decided to write something that makes me feel good about a man from Winona, Mississippi, who has loved me whole and halted my premature death.
</p>
<p class="c-end-para" data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DItiJb">
Today, that is the most loving thing I can do to my insides and Gunn’s. Today, that feels fair.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ehngmh">
<em>Kiese Laymon is the author of three books, including the novel </em><a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fbookshop.org%2Fbooks%2Flong-division-9781467670234%2F9781982174828&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2Fthe-highlight%2F22419450%2Fkiese-laymon-justice-fairness-black-america" rel="sponsored nofollow noopener" target="_blank"><em>Long Division</em></a><em>. </em>
</p>
<div>
<div id="5GW5a6">
<div>
</div>
</div>
</div></li>
<li><strong>Anyone who says they know exactly what’s happening in the economy is lying</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/ZS6WdBlwGlUsB27enDLU6BPrLRM=/335x388:2613x2097/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69297933/GettyImages_1215016310_copy.0.jpg"/>
<figcaption>
Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Anyone who says they know exactly what’s happening in the economy is lying.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1Zvg0K">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ch1zVz">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="70DUHB">
The pandemic economy has been strange and unpredictable from the get-go.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X55aWn">
Throughout the past 14 months, the twists and turns have been surprising: <a href="https://www.vox.com/22264268/covid-19-housing-insecurity-housing-prices-mortgage-rates-pandemic-zoning-supply-demand">The housing market boomed</a>, <a href="https://www.vox.com/business-and-finance/22421417/stock-market-pandemic-economy">the stock market soared</a>, <a href="https://www.vox.com/business-and-finance/2020/7/9/21314119/stock-market-day-trading-reddit-dave-portnoy-barstool-robinhood">people got into day trading</a>, <a href="https://www.vox.com/2020/4/14/21218467/bidets-toilet-paper-shortage-tushy-toto-washlet">everyone hoarded toilet paper</a>, and <a href="https://www.vox.com/22410713/lumber-prices-shortage">lumber became a must-have</a>. There’s been widespread disagreement about how much support from the government was needed, <a href="https://www.vox.com/policy-and-politics/2020/5/15/21258535/coronavirus-economic-recession-congress-heroes-act-reopening-stimulus">whether the country was doing too much or not enough</a>, or whether help would come at all. We won’t know whether the country overshot or undershot the response for years, and there’s still uncertainty about what’s happening in the <a href="https://www.vox.com/policy-and-politics/2021/5/7/22424859/april-jobs-report-economy">labor market</a>, <a href="https://www.vox.com/policy-and-politics/22346376/inflation-rate-explained-federal-reserve">prices</a>, and other areas. And the prevailing theme has been one that has nothing to do with the economy directly: As long as Covid-19 isn’t under control, the economy isn’t either.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DS863r">
“Having been a forecaster for 10 years, we were surprised all the time, because nobody has a crystal ball and particularly if you just pull out one data series, one month, there’s just no way,” said Claudia Sahm, a former Federal Reserve economist and now a senior fellow at the Jain Family Institute. “It’s going to be a wild ride; the data through the end of this year, they’re going to be tough.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FZid8R">
The country and the world are staring into a black box of uncertainty on the economy. It’s frustrating, but it’s also inevitable. Anyone who says they know exactly what is going on in the economy right now is lying. The same goes for anyone who says they know what’s going to happen next.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fdL1Zc">
“Because of the unique nature of this crisis, there are going to be some swings,” said Mike Konczal, director of macroeconomic analysis at the Roosevelt Institute. “In a year, they’re going to be trivia questions, but right now we’re obsessing about them.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lZLpKX">
Few people will probably remember two years from now that <a href="https://slate.com/business/2021/05/used-car-prices-shortage-supply-chain-semiconductors.html">the price of used cars and trucks went up by 10 percent</a> in April.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="haLoqc">
We know that the economy is different now than it was a year ago and that it will be different a year from now. What’s not clear is exactly how. And what we need now — including economists, experts, and policymakers — is the <a href="https://www.vox.com/science-and-health/2019/1/4/17989224/intellectual-humility-explained-psychology-replication">intellectual humility</a> to recognize that’s the case.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZVmAty">
“At this point, most things should be presumed temporary until proven permanent,” said Jed Kolko, chief economist at the jobs website Indeed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KlqsMq">
It’s unnerving to admit what we don’t know, and the pandemic has been a real exercise in that. But after so long of staring into the abyss, maybe it’s time we embrace it.
</p>
<hr class="p-entry-hr" id="7yhdCC"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R34QDq">
The Bureau of Labor Statistics recently <a href="https://www.bls.gov/news.release/pdf/empsit.pdf">reported</a> that the US economy added 266,000 jobs in April, far below the 1 million jobs economists expected, <a href="https://www.vox.com/policy-and-politics/2021/5/7/22424859/april-jobs-report-economy">leaving many people shocked</a>. The number was so shocking that CNBC reporter Steve Liesman <a href="https://www.youtube.com/watch?v=KzNMrkbq6uo">double-checked</a> it live on air. Nick Bunker, an economist at Indeed, <a href="https://www.hiringlab.org/2021/05/07/april-2021-jobs-report/">wrote that it</a> “might be one of the most disappointing jobs numbers of all time.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WkXaPr">
Much of this is a question of expectations. Many economists have anticipated the labor market to bounce back quickly, and with the country still 8 million jobs from where it was pre-pandemic, a quarter-million-jobs-a-month recovery isn’t going to cut it. But one month of data isn’t really enough to definitively say what’s happening with jobs and workers; April could be a blip, or it could be a sign of an ongoing ominous trend. Many economists and experts are trying to extrapolate from it, but they’re also the same economists and experts who didn’t see it coming.
</p>
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There are some things we do know: Employers are posting more jobs, and there is a growing demand to hire. We know that more people are getting vaccinated, and as that happens, hopefully, concerns about contracting Covid-19 will fade. We also know that caregiving is still a burden that many working parents face, and with the school year ending, taking care of kids and working is tough to balance. For some families, going back to work right now might not be worth it. The entire labor situation just is out of whack.
</p>
<div class="c-float-right c-float-hang">
<aside id="Yf16te">
<q>“The economy is reopening and restarting in a way that we really have never seen before”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bfSv6U">
“The economy is reopening and restarting in a way that we really have never seen before, and we know that’s not all going to happen in sync,” Kolko said. “The rate at which employers become more eager to hire won’t match exactly the rate at which job seekers are more eager to start working.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TTdbCD">
We also may not yet have a clear sense of what, exactly, just happened. In the April jobs report, the BLS also revised its numbers from previous months and said that the US actually added more jobs in February and fewer jobs in March than it initially reported. The situation is still fluid. Konczal pointed out that <a href="https://www.bls.gov/web/empsit/cesnaicsrev.htm">monthly revisions to the jobs report</a> — the changes the BLS makes to its estimates of prior months — have been double to triple this year what they have been on average in the past 40 years. “The BLS is trying very hard in very difficult circumstances to get accurate surveys, but it is hard work.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uC0Cr7">
Some business groups, economists, and politicians have seized on the jobs numbers to push their own political priorities. The Chamber of Commerce, for example, <a href="https://twitter.com/USChamber/status/1390670704736149507">called for the US to end expanded unemployment insurance benefits</a> after the April jobs report, arguing that the extra $300 in weekly benefits is keeping people out of the workforce. A handful of states, all run by Republicans, have <a href="https://www.cnn.com/2021/05/11/politics/unemployment-benefits-gop-states/index.html">already announced their plans</a> to wind down expanded unemployment programs next month.
</p>
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Many employers now, and after every economic downturn, complain they can’t find workers and that the social safety net is keeping people on the sidelines. Progressives, meanwhile, insist that expanded unemployment isn’t keeping anyone out of the workforce at all, and if employers want people to take jobs, they should pay more.
</p>
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It’s impossible to parse exactly what is motivating workers at the moment, and what is disincentivizing potential employees and to what extent. <a href="https://www.washingtonpost.com/business/2021/05/07/jobs-report-labor-shortage-analysis/">Unemployment insurance might allow some workers to rethink their priorities a little</a>, but that doesn’t mean that rug should be pulled out from under them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qAMuha">
“There’s always this uncertainty, and it takes some time to get enough data to form a narrative,” Sahm said. “A complex phenomenon has complex causes.”
</p>
<div class="c-wide-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/BLTQnUnqOrmsBHUjbgP_wBBsBI4=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22514848/GettyImages_1217980687.jpg"/> <cite>Getty Images</cite>
</figure>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dFZzuS">
Beyond the basic question of what’s going on in the economy, how permanent or fleeting is it?
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eryVVe">
Take, for example, <a href="https://www.vox.com/policy-and-politics/22346376/inflation-rate-explained-federal-reserve">inflation</a>, which has been creeping up in some areas. The Consumer Price Index (CPI), which measures the average change in prices paid by consumers for things like food, clothes, housing, and transportation, <a href="https://www.wsj.com/articles/inflation-increases-likely-to-prove-transitory-fed-official-says-11620824400">ticked up</a> by 4.2 percent in April compared to a year ago. And in some areas, such as gas and used cars, prices have gone up quite a bit. But the broader question on inflation — and the one the <a href="https://www.wsj.com/articles/inflation-increases-likely-to-prove-transitory-fed-official-says-11620824400">Federal Reserve is focused on</a> as it tries to figure out its next steps on the economy — is whether that inflation is transitory, or to put it more plainly, temporary. Prior to the pandemic, inflation was running confoundingly low in the US economy, and economists were puzzled by why it wasn’t going up. Early on in the pandemic, the economy actually <a href="https://twitter.com/WhiteHouseCEA/status/1381579656617472009">saw some deflation</a>, meaning prices went down. Now, many economists say it’s okay to have some inflation, within reason, and they believe it will be short-lived.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ekTcV2">
“An episode of one-time price increases as the economy reopens is not likely to lead to persistent year-over-year inflation into the future,” said Fed Chair Jay Powell <a href="https://apnews.com/article/financial-markets-health-coronavirus-economy-inflation-bbe992c9352a72f189ffd634fe7c9383">at an April news conference</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w9dn5R">
Again, it depends on how high inflation is and how long it lasts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gMCiKA">
“The progressive economic agenda of spending through a downturn never promised zero inflation. It said the inflation there would be moderate and manageable,” said Lindsay Owens, interim executive director of the progressive think tank Groundwork Collaborative.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GzNKQJ">
The persistent doubt of what is temporary and what is permanent in the burgeoning post-Covid-19 economy is hardly contained to inflation. It often plays out in high-level economic debates, but it’s easy to observe in day-to-day life, too. Plenty of people still don’t know when they’re going to go on vacation again, and when they do, where they’ll be comfortable going. Return-to-office plans are still being hatched, and <a href="https://www.vox.com/recode/22331447/10-ways-office-work-pandemic-future-remote-work">what the future of work looks like is in flux</a>. Whether or not white-collar workers wind up working from home more doesn’t just impact their companies, it also affects the businesses and workers that support them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PmEa2K">
A lot of what’s going on in the economy isn’t going to show up in the data, and if and when it does, it won’t happen for a while. “It’s just this different world, and in this world we’re in, trying to address things at the scale that we are may mean that we don’t have the best tools to watch in real-time, or the way we talk about things aren’t the right way to talk about things,” Konczal said.
</p>
<div class="c-float-right c-float-hang">
<aside id="T3B2Ry">
<q>“The raw ability of the government to stabilize incomes, I think was remarkable given how weak American social infrastructure is.”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IIar0b">
Perhaps a prime example of a rather unexpected development — and one of uncertain durability — is the housing frenzy. Early on in the pandemic, some people expected the housing market, like many parts of the economy, would struggle amid mass unemployment and widespread uncertainty. Instead, prices <a href="https://www.vox.com/covid-19-coronavirus-economy-recession-stock-market/2020/5/29/21273520/housing-market-coronavirus-impact-home-prices-mortgages-crash">didn’t just hold steady</a>, they <a href="https://www.vox.com/22264268/covid-19-housing-insecurity-housing-prices-mortgage-rates-pandemic-zoning-supply-demand">soared</a>. Preexisting trends, such as low mortgage rates and a cohort of home-ready millennials, combined with a pandemic-induced desire to get more space and out of the city, caused a surge in demand. And the supply just wasn’t there. Housing accessibility is not going away as a problem in the US, but the current mania for a single-family home that’s pushed prices so high could fade. Or maybe it won’t. Some economists <a href="https://www.cnbc.com/2020/06/23/housing-market-should-cool-off-later-in-year-moodys-economist-zandi-says.html">predicted</a> it would <a href="https://www.nytimes.com/2021/04/22/realestate/us-home-sales-surge.html">cool off</a> months ago.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RKinIU">
We shouldn’t overlook the curious developments in the economy that have been positive and heartening, either. An unprecedented amount of support from the government, from expanded unemployment to stimulus checks, has helped millions of people and kept them from slipping into poverty. <a href="https://www.wsj.com/articles/consumer-spending-personal-income-march-2021-11619732790">Savings rates increased during the pandemic</a>; <a href="https://www.wsj.com/articles/credit-card-debt-keeps-falling-banks-are-on-edge-11620725580">credit card debt is falling to the point that it’s actually making life harder for banks</a>. People have paused their student loan payments and been able to relax, a little, about the prospect of losing their homes. Part of what makes guessing what will happen in the economy next is that the country has never had a response like this before — no one knows what this amount of stimulus will do, or how quickly or how slowly. Or what will happen when some supports go away.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TkDk1A">
“The raw ability of the government to stabilize incomes, I think was remarkable given how weak American social infrastructure is,” Konczal said. “America can actually do things.”
</p>
<hr class="p-entry-hr" id="VLSeyR"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OCi9Mc">
Nothing about the past year and change has been easy or exactly expected. In some ways, things have been better than anticipated — the vaccine arrived earlier than many believed possible, the economic downturn wasn’t as long and deep as expected, and the government stepped in multiple times to deliver much-needed support. In other ways, it’s been worse — hundreds of thousands of people have died, the economy has experienced a number of fits and starts, and <a href="https://www.vox.com/policy-and-politics/2020/9/29/21494818/k-shaped-economic-recovery-biden-trump-2020-debate">an uneven recovery has taken hold</a>. In other ways, the economy has just been, well, kind of odd (<a href="https://www.vox.com/22421095/chicken-wings-shortage-delivery-bar">who could have expected a shortage of chicken wings</a>, <a href="https://www.vox.com/recode/22428774/ransomeware-pipeline-colonial-darkside-gas-prices">or a cyberattack on an oil pipeline</a>?).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CXSYFn">
In retrospect, many of the developments in the economy make sense. Of course people bored at home decided to renovate. Of course stimulus checks <a href="https://www.vox.com/the-goods/21611583/pawn-shop-covid-19-economy">would make people resort to short-term lenders a little less</a>. The precariousness of domestic and global supply chains is hardly new, nor is the country’s inadequate child care system.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LnQMyr">
“To the extent we’re going to see a problem, it likely reflects long-standing problems we knew were problems before Covid,” Konczal said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JGCDRf">
And Covid-19 exacerbated a lot of problems — problems we’re still reeling from and probably will be for a long time. It felt like the world fell apart in 2020, and it’s going to take a long time to put it back together.
</p>
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</p>
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</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZVyEwF">
</p></li>
<li><strong>The Fairness Issue</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/UdumDHf_-J7XVZE7RXAltKYS3iI=/53x0:952x674/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69265684/format_16_9_V01.0.gif"/>
<figcaption>
Diana Ejaita for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Together, the pandemic and the death of George Floyd revealed to all Americans the rampant inequities and stratifications many face. But is fairness the goal?
</p>
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</p>
<div class="c-float-left">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/YYgW4HsU995yniG4Y5QuEoQvF0Y=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/21899595/VOX_The_Highlight_Box_Logo_Horizontal.png"/>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ji5tH4">
It’s never been a secret that life isn’t fair; it bears out in countless racial, gendered, economic, and geographical ways throughout a lifetime.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="p5H22g">
But even the most privileged and the most sheltered were made to confront the stratification of American society in the past year, as the coronavirus pandemic laid bare the troubling disparities between those who could weather its financial and logistical disruptions to everyday life and those who could not; and between those who would survive its wrath and those who would not. The murder of George Floyd and subsequent protests and racial reckonings a year ago have only further illuminated these realities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zn4Rhp">
What this past year has shown us is that the concept of “fairness” is slippery. On the one hand, it’s a legible, admirable, seemingly unproblematic goal — enough for everyone, tit for tat, books balanced and parity achieved. It’s neat and it’s simple.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="49i39a">
Fairness, it can also be argued, is the province of children. It’s for remote control dominance and ice cream cone distribution; it’s a way of reducing what ought to be multifaceted into a flat and faceless zero-sum transaction. “Life’s not fair!” is one of the most recognizable phrases kids who have just achieved a grasp of the English language can utter; “life’s not fair,” its natural rejoinder, serves as both an early entry point into the inherent inequities of the world and a catchall statement meant to justify whatever the adult uttering it happens to want in a given moment (generally peace, quiet, and a cupcake sans fingerprints in the frosting). It’s infantile and futile to desire fairness; it’s cruel and hopeless not to.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PVuRPU">
In this month’s issue of The Highlight, we explore this tension. Each piece wrestles with a different definition of fairness, from a feature by labor writer Sarah Jaffe on the false promise of the gig economy to a comic by Melinda Fakuade and Kazimir Lee examining how couples split bills.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="26kLWa">
At its most insidious, fairness can be trotted out under the guise of equality only to be used as a tool of oppression against the most vulnerable, as Jessica W. Luther writes in her piece about the wave of legislation meant to exclude trans girls and women from participating in sports. At its best, as seen in Carol Kuruvilla’s interviews with seven religious leaders, it operates in tandem alongside its more powerful cousins — kindness, restoration, and, above all, justice — to make a blueprint for a world worth aspiring to. And sometimes, as Kiese Laymon so beautifully writes in an essay about Blackness in America, fairness is shunting aside what’s asked of you, and giving yourself the grace to revisit, revise, and reexamine what you are owed and what you yourself owe your people.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P6d2hr">
These pieces together raise the notion that fairness in and of itself isn’t, and shouldn’t be, the goal toward which we strive. It’s simply the most obvious result of a far more complex interplay of needs and systems. As Imam Omar Suleiman, president of the Yaqeen Institute for Islamic Research, told Kuruvilla, “If justice is the tree, fairness is the fruit.”
</p>
<hr class="p-entry-hr" id="1Gq9Tv"/>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/L96tIWxeUTrcGiNRO15N5oSyhjU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22509802/GettyImages_1021251776_cropped.jpg"/> <cite>Getty Images</cite>
</figure>
<h3 id="noj00Z">
<a href="https://www.vox.com/the-highlight/22423132/anti-transgender-bills-women-sports-fairness">The playing field</a>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eLAoNY">
Anti-trans bills purport to address “fairness” in sports. But sports have never been fair.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lLrOJz">
By Jessica W. Luther
</p>
<hr class="p-entry-hr" id="WdFDNN"/>
<figure class="e-image">
<img alt="An illustration of a ride-share driver behind the wheel of a car." src="https://cdn.vox-cdn.com/thumbor/naCq7zP8dQYEOyFcv8OLkszsiQs=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22499762/Vox_Final.jpg"/> <cite>Kailey Whitman for Vox</cite>
</figure>
<h3 id="CXkVzX">
The battle for the future of “gig” work<em> (coming Tuesday)</em>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V9Sxx2">
Ride-sharing companies are pushing to make a third category of “independent” worker the law of the land. Drivers say the notion of independence is little more than a mirage.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LMJsVY">
By Sarah Jaffe
</p>
<hr class="p-entry-hr" id="HK4Rg6"/>
<figure class="e-image">
<img alt="An illustration shows a man looking in the mirror at another version of himself, like a funhouse mirror." src="https://cdn.vox-cdn.com/thumbor/2HdncD9SiUWJ6o_R3ZzLEKxvD1s=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22503550/Fairness_Family_Final_Revised.jpg"/> <cite>Carlos Basabe for Vox</cite>
</figure>
<h3 id="qVZbig">
What we owe and are owed <em>(coming Wednesday)</em>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x0fAKQ">
Kiese Laymon on Black revision, repayment, and renewal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eUt5TK">
By Kiese Laymon
</p>
<hr class="p-entry-hr" id="6zZLmX"/>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/8xa-3Q8irues_bC8a2t1sTF8Nlw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22509804/GettyImages_1173357732_cropped.jpg"/> <cite>Getty Images/iStockphoto</cite>
</figure>
<h3 id="F4yBlP">
How can we make it right? What the world’s religions have to say about justice.<em> (coming Thursday) </em>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Akp18G">
From a Buddhist to a humanist, seven faith leaders weigh in on building a better world.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1n2BPX">
By Carol Kuruvilla
</p>
<hr class="p-entry-hr" id="oX7vuC"/>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/nW7yj6isud6ODppFPI63POKItUQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22502433/header.jpeg"/> <cite>Kazimir Lee</cite>
</figure>
<h3 id="2JXW13">
The last frontier in modern romance is money <em>(coming Friday)</em>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YTneeg">
As dating and marriage evolve, so is the way couples are splitting finances.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eoekXk">
By Melinda Fakuade and Kazimir Lee
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KWG9rI">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kDLjYw">
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jofra Archer ruled out of NZ series after elbow injury flares up</strong> - Archer could play only two of the four away Tests against India and missed the IPL</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australian IPL cricketers return home after Maldives stop-over</strong> - Most of the 38 members of the Australian contingent, including players, officials and commentators who participated at the non-suspended league, landed at the Sydney airport on Monday morning</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Goalkeeper Alisson saves Liverpool’s season, with a goal</strong> - It was the first time in Liverpool’s history that a goalkeeper had scored a competitive goal.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Barcelona beats Chelsea 4-0 to win Women’s Champions League final for first time</strong> - Barça is the first team from Spain to win Europe’s top club competition, which had been dominated recently by seven-time champions Lyon.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Italian Open | Nadal overcomes blip to scythe down Djokovic in Rome final</strong> - After a mid-match wobble, Nadal turned up the heat in the decisive moments of his 57th meeting with top seed Djokovic to secure the victory over the defending champion in two hours and 49 minutes</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Helpline for senior citizens to be fully functional by May end</strong> - ‘Elderline’ has already started in U.P., M.P., Rajasthan, Tamil Nadu and Karnataka, says Social Justice Ministry.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>HC upholds regulation of lotteries of other States</strong> - Sets aside single judge’s order on sale of lottery tickets of Nagaland</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus | Mini-covid care centres in Chandigarh ease patients’ burden</strong> - Besides doctors and nurses, they are also providing free food, medicines and care.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SC orders medical examination of MP at Army Hospital</strong> - Apex court posts hearing on bail plea of Raghu Ramakrishna Raju to May 21</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus | Few clotting events post-Covishield jab: AEFI panel</strong> - Health Ministry issues advisory of potential thromboembolic incidents</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid-19: Thousands head overseas on holiday as rules ease</strong> - Holidaymakers from England, Scotland and Wales are now able to jet off for some early summer sun.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Long working hours killing 745,000 people a year, study finds</strong> - The World Health Organization says the trend may worsen due to the coronavirus pandemic.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UK plastic waste being dumped and burned in Turkey, says Greenpeace</strong> - Greenpeace says it found plastic waste from UK supermarkets dumped and burned at numerous sites.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cyber-crime: Irish health system targeted twice by hackers</strong> - Department of Health confirms its IT systems was hit by a ransomware attack last Thursday.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lockdown rules ease for millions in UK</strong> - Rules on socialising indoors and foreign travel are lifted in England, Wales and most of Scotland.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neutrons unlock the secrets of Antonie van Leeuwenhoek’s microscopes</strong> - His most powerful microscope holds a lens likely made with Robert Hooke’s 1678 recipe. - <a href="https://arstechnica.com/?p=1765022">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google I/O 2021 preview: Google resurrects Wear OS and Android tablets?</strong> - The Google I/O schedule promises to resurrect some long-dead form factors. - <a href="https://arstechnica.com/?p=1764606">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>GameStop FOMO inspires a new wave of crypto pump-and-dumps</strong> - Discord groups promise big earnings by manipulating the crypto market. - <a href="https://arstechnica.com/?p=1765272">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The chip shortage is driving up tech prices–starting with TVs</strong> - Some high-end televisions already cost 30% more than they did last summer. - <a href="https://arstechnica.com/?p=1765280">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Colonial Pipeline paid a $5 million ransom—and kept a vicious cycle turning</strong> - Stopping payments would go a long way to stopping ransomware. - <a href="https://arstechnica.com/?p=1765276">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>I threw my wife a surprise bukake party</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Everyone came. You should have seen her face.
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/CrytoNice"> /u/CrytoNice </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ndyyl8/i_threw_my_wife_a_surprise_bukake_party/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ndyyl8/i_threw_my_wife_a_surprise_bukake_party/">[comments]</a></span></p></li>
<li><strong>A baby roach asks his dad what happens if they get sprayed with Raid.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Papa Roach said, “Suffocation, no breathing.”
</p>
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Arvanti_Golpitan_III"> /u/Arvanti_Golpitan_III </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ne17la/a_baby_roach_asks_his_dad_what_happens_if_they/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ne17la/a_baby_roach_asks_his_dad_what_happens_if_they/">[comments]</a></span></p></li>
<li><strong>A man in an interrogation room says “I’m not saying a word without my lawyer present.”</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Cop: You are the lawyer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Lawyer: Exactly, so where’s my present?
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/PotatoLatte"> /u/PotatoLatte </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ndovig/a_man_in_an_interrogation_room_says_im_not_saying/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ndovig/a_man_in_an_interrogation_room_says_im_not_saying/">[comments]</a></span></p></li>
<li><strong>A lady finally found her soulmate and calls her dad to tell him about it</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
(Translated from romanian, hopefully you will get it lol)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The dad is smiling and eager to find out more about this man he asks even more questions about her new lover.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She tells him that he is smart, beautiful, finished his studies at a highly prestigious university and now he is working as an engineer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The dad asks “So where did he finish?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
And the girl replies “On my boobs!”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/jukabukaer"> /u/jukabukaer </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ndrq9k/a_lady_finally_found_her_soulmate_and_calls_her/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ndrq9k/a_lady_finally_found_her_soulmate_and_calls_her/">[comments]</a></span></p></li>
<li><strong>My 4-year-old nephew has been learning Spanish since lockdown.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He still can’t say the word for “please” though, which I think is poor for four
</p>
</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/tushar-gunner"> /u/tushar-gunner </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/neagrp/my_4yearold_nephew_has_been_learning_spanish/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/neagrp/my_4yearold_nephew_has_been_learning_spanish/">[comments]</a></span></p></li>
</ul>
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