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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Điểm tin RW Weekend Read ngày 16-1-2021</strong> -
<div>
Bản Weekend Read của RetractionWatch ngày 16-1 có tựa đề: Pollution of COVID-19 research; climate papers lead to reassignment; time to publish less?
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/xgqd6/" target="_blank">Điểm tin RW Weekend Read ngày 16-1-2021</a>
</div></li>
<li><strong>How should we present the epidemic curve for COVID-19?</strong> -
<div>
Epidemic curves are used by decision makers and the public to infer the trajectory of the COVID-19 pandemic and to understand the appropriateness of current response measures. Symptom onset date is commonly used to date cases on the epidemic curve in public health reports and dashboards. However, third-party trackers often plot cases on the epidemic curve by the date they were publicly reported by the public health authority. These two curves create very different impressions of epidemic progression. On April 1, the epidemic curve for Ontario, Canada based on public reporting date showed an accelerating epidemic, whereas the curve based on a proxy variable for symptom onset date showed a rapidly declining epidemic. This illusory downward trend (the "ghost trend") is a feature of epidemic curves anchored using date variables earlier in time than the date a case was publicly reported, such as symptom onset date or sample collection date. This is because newly discovered cases are backdated, creating a perpetual downward trend in incidence due to incomplete data in the most recent days. Public reporting date is not subject to backdating bias and can be used to visualize real-time epidemic curves meant to inform the public and policy makers.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/zfj8a/" target="_blank">How should we present the epidemic curve for COVID-19?</a>
</div></li>
<li><strong>Mapping the Landscape of COVID-19 Crisis Visualizations</strong> -
<div>
In response to COVID-19, a vast number of visualizations have been created to communicate information to the public. Information exposure in a public health crisis can impact people’s attitudes towards and responses to the crisis and risks, and ultimately the trajectory of a pandemic. As such, there is a need for work that documents, organizes, and investigates what COVID-19 visualizations have been presented to the public. We address this gap through an analysis of 668 COVID-19 visualizations. We present our findings through a conceptual framework derived from our analysis, that examines who, (uses) what data, (to communicate) what messages, in what form, under what circumstances in the context of COVID-19 crisis visualizations. We provide a set of factors to be considered within each component of the framework. We conclude with directions for future crisis visualization research.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/kd3y9/" target="_blank">Mapping the Landscape of COVID-19 Crisis Visualizations</a>
</div></li>
<li><strong>Resilience, mood, and mental health outcomes during the first wave of the COVID-19 pandemic in Bulgaria</strong> -
<div>
Background: The fundamental challenges of the COVID-19 pandemic may have lasting negative effects on the quality of mental health worldwide. Resilience is considered an important protective factor in reducing the risk of psychopathology in the face of various adverse events, such as the ongoing health crisis. The aims of the current study were to: (1) evaluate the predictive utility of resilience in accounting for positive and negative moods, substance use, depression and anxiety; and (2) compare negative and positive moods experienced before the pandemic to emotions reported during the first wave of the COVID-19 pandemic in Bulgaria, when the country still had low prevalence of infections and fatalities. Methods: 179 Bulgarian participants completed the international online Minnesota Global Survey on Stress and Resilience in the Face of the Novel Coronavirus (COVID-19), which included measures of resilience, depression and anxiety, substance use, positive and negative moods experienced both before and during the COVID-19 outbreak. Results: Resilience predicted higher levels of positive affect and lower anxiety, depression, and negative mood during the first wave of the COVID-19 outbreak in Bulgaria. A significant increase was found in negative mood and a corresponding decrease in positive mood in the time since COVID-19 began spreading compared to before the pandemic. Conclusions: Results suggest that the initial wave of the COVID-19 crisis impacted individuals’ well-being, even in countries with relatively low prevalence of COVID-19 and associated fatalities. In this challenging global setting, resilience may serve as a buffer against negative emotional states and psychological distress.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/8nraq/" target="_blank">Resilience, mood, and mental health outcomes during the first wave of the COVID-19 pandemic in Bulgaria</a>
</div></li>
<li><strong>Probability Discounting and Adherence to Preventive Behaviors During the COVID-19 Pandemic</strong> -
<div>
This brief communication reports preliminary findings of a study conducted to investigate the relationship between probability discounting and people’s adherence to preventive behaviors recommended during the COVID-19 pandemic. A sample of 112 adults living in Brazil completed an online survey composed of a Probability Discounting Questionnaire (PDQ) and a 10-item assessment of how often they complied with the health authorities’ recommendations (e.g., wash the hands frequently, practice social distancing, stay at home as much as possible, wear a mask when in public). Data analysis included the participants who showed higher (n = 40) and lower (n = 40) adherence to preventive behaviors. Results revealed that probability discounting measures are related to people’s preventive actions. Participants in the higher adherence group present significantly larger risk aversion indices (i.e., larger h values) than participants in the lower adherence group. Also, participants who showed lower adherence to preventive behaviors were more likely to perform risky choices in the PDQ than participants who demonstrated higher compliance with health authorities’ recommendations. These preliminary results suggest that probability discounting can play an essential role in people’s self-protective decisions during a global health emergency, such as the COVID-19 pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/p4a76/" target="_blank">Probability Discounting and Adherence to Preventive Behaviors During the COVID-19 Pandemic</a>
</div></li>
<li><strong>Integrating health behavior theories to predict COVID-19 vaccines uptake intent among the American public</strong> -
<div>
Wide uptake of coronavirus disease 2019 (COVID-19) vaccines is key to containing the ongoing pandemic. Integrating constructs from three prominent health behavior theories (HBT) including the extended parallel process model (EPPM), the health belief model (HBM) and the theory of planned behavior (TPB), the current study seeks to identify sociopsychological factors that influence American public’s COVID-19 vaccines uptake intent. An online survey was delivered to a national sample (N = 934) with demographic composition similar to the U.S. population. This study assessed the influences of risk perception and fear associated with COVID-19, beliefs about and attitudes toward COVID-19 vaccines, self-efficacy, social and psychological contexts, and demographic characteristics on people’s intention to get COVID-19 vaccines. Most respondents intended to get a COVID-19 vaccine once it is available. However, participants tended to underestimate their risks of contracting COVID-19, which may prevent them from getting vaccinated. Exposure to COVID-19 infections and deaths led to higher uptake intent via the mediation of fear. Concerns about the safety of COVID-19 vaccines negatively influenced vaccination intention, while perceived community benefits of the vaccines were positively associated with vaccination intention. Positive attitudes toward vaccines in general and recent vaccine history were also positively linked to COVID-19 vaccines uptake intent. This study attests the effectiveness of HBT constructs in predicting COVID-19 vaccines uptake intent. The results point to the importance of fostering confidence in vaccine safety in interventions seeking to promote COVID-19 vaccines uptake.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/hvxjf/" target="_blank">Integrating health behavior theories to predict COVID-19 vaccines uptake intent among the American public</a>
</div></li>
<li><strong>A Serology Strategy for Epidemiological Studies Based on the Comparison of the Performance of Seven Different Test Systems - The Representative COVID-19 Cohort Munich</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background. Serosurveys are essential to understand SARS-CoV-2 exposure and enable population-level surveillance, but currently available tests need further in-depth evaluation. We aimed to identify testing-strategies by comparing seven seroassays in a population-based cohort. Methods. We analysed 6,658 samples consisting of true-positives (n=193), true-negatives (n=1,091), and specimens of unknown status (n=5,374). For primary testing, we used Euroimmun-Anti-SARS-CoV-2-ELISA-IgA/IgG and Roche-Elecsys-Anti-SARS-CoV-2; and virus-neutralisation, GeneScript(R)cPassTM, VIRAMED-SARS-CoV-2-ViraChip(R), and Mikrogen-recomLine-SARS-CoV-2-IgG, including common-cold CoVs, for confirmatory testing. Statistical modelling generated optimised assay cut-off-thresholds. Findings. Sensitivity of Euroimmun-anti-S1-IgA was 64.8%, specificity 93.3%; for Euroimmun-anti-S1-IgG, sensitivity was 77.2/79.8% (manufacturer9s/optimised cut-offs), specificity 98.0/97.8%; Roche-anti-N sensitivity was 85.5/88.6%, specificity 99.8/99.7%. In true-positives, mean and median titres remained stable for at least 90-120 days after RT-PCR-positivity. Of true-positives with positive RT-PCR (&lt;30 days), 6.7% did not mount detectable seroresponses. Virus-neutralisation was 73.8% sensitive, 100.0% specific (1:10 dilution). Neutralisation surrogate tests (GeneScript(R)cPassTM, Mikrogen-recomLine-RBD) were &gt;94.9% sensitive, &gt;98.1% specific. Seasonality had limited effects; cross-reactivity with common-cold CoVs 229E and NL63 in SARS-CoV-2 true-positives was significant. Conclusion. Optimised cut-offs improved test performances of several tests. Non-reactive serology in true-positives was uncommon. For epidemiological purposes, confirmatory testing with virus-neutralisation may be replaced with GeneScript(R)cPassTM or recomLine-RBD. Head-to-head comparisons given here aim to contribute to the refinement of testing-strategies for individual and public health use.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.13.21249735v1" target="_blank">A Serology Strategy for Epidemiological Studies Based on the Comparison of the Performance of Seven Different Test Systems - The Representative COVID-19 Cohort Munich</a>
</div></li>
<li><strong>Metabolic markers distinguish COVID-19 from other intensive care patients and show potential to stratify for disease risk</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Coronavirus disease 2019 (COVID-19) is a viral infection affecting multiple organ systems of great significance for metabolic processes. Thus. there is increasing interest in metabolic and lipoprotein signatures of the disease and early analyses have demonstrated metabolic pattern typical for atherosclerotic and hepatic damage in COVID-19 patients. However, it remains unclear whether these are specific for COVID-19 or a general marker of critical illness. To answer this question, we have analyzed 276 serum samples from 92 individuals using NMR metabolomics, including longitudinally collected samples from 5 COVID-19 and 11 cardiogenic shock intensive care patients, 18 SARS-CoV-2 antibody-positive individuals, and 58 healthy controls. COVID-19 patients showed a distinct metabolic serum profile, including changes typical for severe dyslipidemia and a deeply altered metabolic status compared to healthy controls. Specifically, VLDL parameters, IDL particles, large-sized LDL particles, and the ApoB100/ApoA1 ratio were significantly increased, whereas HDL fractions were decreased. Moreover, a similarly perturbed profile was apparent, even when compared to other ICU patients suffering from cardiogenic shock, highlighting the impact of COVID-19 especially on lipid metabolism and energy status. COVID-19 patients were separated with an AUROC of 1.0 when compared to both healthy controls and cardiogenic shock patients. Anti-SARS-CoV-2 antibody-positive individuals without acute COVID-19 did not show a significantly perturbed metabolic profile compared to age- and sex-matched healthy controls, but SARS-CoV-2 antibody-titers correlated significantly with metabolic parameters, including levels of glycine, ApoA2, and small-sized LDL and HDL subfractions. Our data suggest that NMR metabolic profiles are suitable for COVID-19 patient stratification and post-treatment monitoring.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.13.21249645v1" target="_blank">Metabolic markers distinguish COVID-19 from other intensive care patients and show potential to stratify for disease risk</a>
</div></li>
<li><strong>Risk-driven responses to COVID-19 eliminate the tradeoff between lives and livelihoods</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background- Responses to COVID-19 pandemic are conditioned by a perceived tradeoff between saving lives and paying the economic costs of contact-reduction measures. We develop and test the hypothesis that when populations endogenously respond to risk this tradeoff disappears. Methods- We develop a model of SARS-CoV-2 transmission where populations endogenously reduce contacts in response to risk of death. We estimate the model for 118 countries constituting 7.05 billion people and assess the existence of a tradeoff between saving lives and livelihoods. Results- We show that with endogenous responses communities go through three phases: rapid early outbreaks, control through initial response, and a longer period of quasi-equilibrium endemic infection with effective reproduction number (Re) fluctuating around one. Analytical characterization of this phase shows little tradeoff between contact reduction levels (underpinning economic costs) and death rates. Empirically estimating the model, we find no positive correlation (r = -0.241, p = 0.009) between (log) death rates and (normalized) contact levels across nations. While contact reduction levels are broadly similar across countries (5-95 percentile: 0.521-0.867 of pre-pandemic contacts), expected death rates vary greatly, by over two orders of magnitude (5-95 percentile: 0.03-17 deaths per million per day). This finding holds whether contact reduction is measured based on transmission rates or mobility data. Interpretation- Whether by choice or by the force of crippling death tolls, most societies will bring down interactions enough to contain SARS-CoV-2s spread. What we control is the severity of death toll required to compel us to act: greater responsiveness to risk can bring down deaths with no excess economic costs.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.11.20247924v2" target="_blank">Risk-driven responses to COVID-19 eliminate the tradeoff between lives and livelihoods</a>
</div></li>
<li><strong>A Metapopulation Network Model for the Spreading of SARS-CoV-2: Case Study for Ireland</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
We present preliminary results on an all-Ireland network modelling approach to simulate the spreading the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), commonly known as the coronavirus. In the model, nodes correspond to locations or communities that are connected by links indicating travel and commuting between different locations. While this proposed modelling framework can be applied on all levels of spatial granularity and different countries, we consider Ireland as a case study. The network comprises 3440 electoral divisions (EDs) of the Republic of Ireland and 890 superoutput areas (SOAs) for Northern Ireland, which corresponds to local administrative units below the NUTS 3 regions. The local dynamics within each node follows a phenomenological SIRX compartmental model including classes of Susceptibles, Infected, Recovered and Quarantined (X) inspired from Science 368, 742 (2020). For better comparison to empirical data, we extended that model by a class of Deaths. We consider various scenarios including the 5-phase roadmap for Ireland. In addition, as proof of concept, we investigate the effect of dynamic interventions that aim to keep the number of infected below a given threshold. This is achieved by dynamically adjusting containment measures on a national scale, which could also be implemented at a regional (county) or local (ED/SOA) level. We find that - in principle - dynamic interventions are capable to limit the impact of future waves of outbreaks, but on the downside, in the absence of a vaccine, such a strategy can last several years until herd immunity is reached.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.06.26.20140590v4" target="_blank">A Metapopulation Network Model for the Spreading of SARS-CoV-2: Case Study for Ireland</a>
</div></li>
<li><strong>Hunt Regional Medical Center Policy for Dapsone administration of ARDS by SARS-CoV-2</strong> -
<div>
A covid-19 committee at Hunt regional Medical centre reviewed the use of Dapsone use as an off label medication based upon treatment adjuncts and inflammasome thesis. It recommends that any physician can write this prescription. However, to ensure safe, appropriate, and accurate administration. Following general guidance is recommended.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/9c7wz/" target="_blank">Hunt Regional Medical Center Policy for Dapsone administration of ARDS by SARS-CoV-2</a>
</div></li>
<li><strong>Optimizing vaccine allocation for COVID-19 vaccines: critical role of single-dose vaccination.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Most of the COVID-19 vaccines require two doses, at least 3 weeks apart. In the first few months of vaccine deployment, vaccine shortages will be inevitable. Current vaccine prioritization guidelines for COVID-19 vaccines all assume two-dose vaccine deployment. However, vaccinating twice as many people with a single dose of vaccine might be a better use of resources. Utilizing an age-stratified mathematical model combined with optimization algorithms, we determined the optimal vaccine allocation with one and two doses of vaccine to minimize five key metrics of disease burden (total infections, symptomatic infections, deaths, peak non-ICU and ICU hospitalizations) under a variety of assumptions (different levels of social distancing, vaccine availability, mode of action of vaccines, vaccination rate). Our results suggest that maintaining current social distancing interventions and speedy vaccine deployment are key for successful vaccination campaigns. Further, we show that the optimal allocation of vaccine critically depends on the single-dose efficacy (SDE). If the SDE is high, then under the majority of scenarios considered, single-dose vaccination is the optimal use of vaccine, preventing up to 48% more deaths than a strategy allocating vaccine to the high-risk (older age groups in our model) first. If the SDE is low or medium, then our results suggest that mixed vaccination campaigns with one and two doses of vaccine are best. Our work suggests that it is an absolute imperative to quickly and fully determine the efficacy of single-dose vaccines, as single-dose vaccinations can put an end to this pandemic much more quickly.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.31.20249099v2" target="_blank">Optimizing vaccine allocation for COVID-19 vaccines: critical role of single-dose vaccination.</a>
</div></li>
<li><strong>Household Transmission of SARS-COV-2: Insights from a Population-based Serological Survey</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Knowing the transmissibility of asymptomatic infections and risk of infection from household- and community-exposures is critical to SARS-CoV-2 control. Limited previous evidence is based primarily on virologic testing, which disproportionately misses mild and asymptomatic infections. Serologic measures are more likely to capture all previously infected individuals. Objective: Estimate the risk of SARS-CoV-2 infection from household and community exposures, and identify key risk factors for transmission and infection. Design: Cross-sectional household serosurvey and transmission model. Setting: Geneva, Switzerland Participants: 4,524 household members 5 years and older from 2,267 households enrolled April-June 2020. Measurements: Past SARS-CoV-2 infection confirmed through IgG ELISA. Chain-binomial models based on the number of infections within households used to estimate the cumulative extra-household infection risk and infection risk from exposure to an infected household member by demographics and infector9s symptoms. Results: The chance of being infected by a SARS-CoV-2 infected household member was 17.3% (95%CrI,13.7-21.7%) compared to a cumulative extra-household infection risk of 5.1% (95%CrI,4.5-5.8%). Infection risk from an infected household member increased with age, with 5-9 year olds having 0.4 times (95%CrI, 0.07-1.4) the odds of infection, and 65 years and older having 2.7 (95%CrI,0.88-7.4) times the odds of infection of 20-49 year olds. Working-age adults had the highest extra-household infection risk. Seropositive asymptomatic household members had 69.6% lower odds (95%CrI,33.7-88.1%) of infecting another household member compared to those reporting symptoms, accounting for 14.7% (95%CrI,6.3-23.2%) of all household infections. Limitations: Self-reported symptoms, small number of seropositive kids and imperfect serologic tests. Conclusion: The risk of infection from exposure to a single infected household member was more than three-times that of extra-household exposures over the first pandemic wave. Young children had a lower risk of infection from household members. Asymptomatic infections are far less likely to transmit than symptomatic ones but do cause infections.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.04.20225573v2" target="_blank">Household Transmission of SARS-COV-2: Insights from a Population-based Serological Survey</a>
</div></li>
<li><strong>Digital Parent Training RCT Meta-Analysis and Systematic Review</strong> -
<div>
Telehealth interventions have the opportunity to scale evidenced-based therapeutics and increase service access to historically hard to reach populations, including rural, and minority groups. Behavior management parenting interventions are a best-practice intervention to treat a range of disruptive behavior disorders and family dysfunction concerns, which have traditionally occurred in person, but recently been trialed online due to growing demand and a need for remote delivery during COVID-19. There is limited and mixed information to date regarding evidence for online services and minimal research on client and therapeutic factors associated with better outcomes, which is critical for advancing efficacy in the rapidly-growing approach to treating child mental illness. Therefore, we conducted a systematic review and meta-analysis (k = 24, total number of intervention participants = 1469 and control participants = 800) of the impact of digital parent training interventions on parent skill, parent mental health, and child externalizing mental health outcomes from 2000 to 2020, among children 2-12 years old, across four databases. Exclusionary criteria include programs targeted for parents of children with intellectual disabilities, autism, brain injury, nutrition/health/dental needs or primary medical diagnosis. Across outcomes, there was a modest effect size of digital parent training interventions (g =.22-.30), compared to controls using random effect two-level and multi-level models. Study heterogeneity varied across outcomes (I² = 18.6% to 66.3%). Results of publication bias were mixed across tests, but they were suggestive of a slight inflation of the effects sizes across outcomes. We tested several moderators related to child demographics, family socioeconomic status, intervention design, and risk of bias. We found the effects of digital parent training on parent skills and child outcomes were stronger if the intervention used was evidence-based, combined hybrid interactive platforms with a therapist and was compared to an inactive control. Given the limitations from the existing literature assess moderating effects regarding population characteristics (i.e. SES, parent mental health), we call on future studies to provide standardized demographics to aide future knowledge synthesis work and provide templates for shared measurement. We preregistered our meta-analysis here, with datafile, code and supplementary: https://osf.io/e35bt/.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/cpd9b/" target="_blank">Digital Parent Training RCT Meta-Analysis and Systematic Review</a>
</div></li>
<li><strong>SARS-CoV-2 seropositivity and seroconversion in patients undergoing active cancer-directed therapy</strong> -
<div>
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Multiple studies have demonstrated the negative impact of cancer care delays during the COVID-19 pandemic, and transmission mitigation techniques are imperative for continued cancer care delivery. To gauge the effectiveness of these measures at the University of Pennsylvania, we conducted a longitudinal study of SARS-CoV-2 antibody seropositivity and seroconversion in patients presenting to infusion centers for cancer-directed therapy between 5/21/2020 and 10/8/2020. Participants completed questionnaires and had up to five serial blood collections. Of 124 enrolled patients, only two (1.6%) had detectable SARS-CoV-2 antibodies on initial blood draw, and no initially seronegative patients developed newly detectable antibodies on subsequent blood draw(s), corresponding to a seroconversion rate of 0% (95%CI 0.0-4.1%) over 14.8 person-years of follow up, with a median of 13 healthcare visits per patient. These results suggest that cancer patients receiving in-person care at a facility with aggressive mitigation efforts have an extremely low likelihood of COVID-19 infection.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.15.21249810v1" target="_blank">SARS-CoV-2 seropositivity and seroconversion in patients undergoing active cancer-directed therapy</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dexamethasone for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Dexamethasone<br/><b>Sponsor</b>:   University of Oklahoma<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Ivermectin 0.6mg/kg/day;   Drug: Ivermectin 1.0mg/kg/day;   Drug: Placebo;   Drug: Hydroxychloroquine<br/><b>Sponsor</b>:   Corpometria Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: ORTD-1 low dose;   Drug: ORTD-1 mid dose;   Drug: ORTD-1 high dose;   Other: Vehicle control<br/><b>Sponsor</b>:   Oryn Therapeutics, LLC<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process<br/><b>Sponsor</b>:   Hospices Civils de Lyon<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMUNOR® Preparation in the Prevention of COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: IMUNOR<br/><b>Sponsor</b>:   University Hospital Ostrava<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Adult</strong> - <b>Condition</b>:   Covid19 Vaccine<br/><b>Interventions</b>:   Biological: MVC-COV1901(S protein with adjuvant);   Biological: MVC-COV1901(Saline)<br/><b>Sponsor</b>:   Medigen Vaccine Biologics Corp.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Vitamin C 500 MG Oral Tablet;   Drug: Tenofovir disoproxyl fumarate 300 MG Oral Tablet;   Drug: Tenofovir disoproxyl fumarate 300 MG plus emtricitabine 200 MG Oral Tablet<br/><b>Sponsors</b>:   Universidade Federal do Ceara;   Conselho Nacional de Desenvolvimento Científico e Tecnológico;   São José Hospital for Infectious Diseases - HSJ;   Central Laboratory of Public Health of Ceará - Lacen-CE<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Safety and Efficacy of Pyronaridine-artesunate (Pyramax® or Artecom®)in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Artecom® (pyronaridine-artesunate);   Drug: Placebo<br/><b>Sponsor</b>:   Shin Poong Pharmaceutical Co. Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Participants ≥ 60 Years of Age and Hospitalized With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: BGE-175;   Other: Placebo<br/><b>Sponsor</b>:   BioAge Labs, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Betadine© bucal 100 mg/ml;   Drug: Oximen® 3%;   Drug: Clorhexidine Dental PHB©;   Drug: Vitis Xtra Forte©;   Drug: Distilled Water<br/><b>Sponsors</b>:   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   Hospital Universitario Fundación Jiménez Díaz;   Hospital Universitario General de Villalba;   Hospital Universitario Infanta Elena;   Hospital Universitario Virgen de la Arrixaca;   Hospital Clínico Universitario de Valencia;   Dentaid SL<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Deep Breathing Exercise on Dyspnea, Anxiety and Quality of Life in Patients Treated for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Behavioral: Deep Breathing Exercise with Triflo<br/><b>Sponsor</b>:   Ankara University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RU Anti-SARS-CoV-2 (COVID-19) mAbs in Healthy Volunteers</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: C144-LS and C-135-LS<br/><b>Sponsor</b>:   Rockefeller University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Drug: Cefditoren pivoxil 400mg<br/><b>Sponsor</b>:   Meiji Pharma Spain S.A.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of COVID-19 Outbreak in Hospital Departments of Bamako, Mali</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Diagnostic Test: SARS-CoV-2 screening by molecular biology;   Diagnostic Test: Serological screening<br/><b>Sponsor</b>:   Institut National de la Santé Et de la Recherche Médicale, France<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: Glycine;   Dietary Supplement: N-acetylcysteine;   Dietary Supplement: Alanine<br/><b>Sponsor</b>:   Baylor College of Medicine<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Micronutrients and bioactive substances: Their potential roles in combating COVID-19</strong> - CONCLUSIONS: The roles of micronutrients and bioactive substances in the fight against COVID-19 are exciting areas of research. This review may suggest directions for further study.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan</strong> - The pandemic of COVID-19 is still ongoing, and many studies on serum antibodies have been reported, however, there are few studies about asymptomatic and mild patients. In this study, we enrolled 44 COVID-19 patients with relatively mild disease and 48 pre-pandemic controls. We measured serum antibodies against extracellular domain, S1 domain, and receptor-binding domain of Spike and N protein, examined neutralization titers by authentic virus neutralization assay and newly-developed...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses</strong> - Severe emerging and re-emerging viral infections such as Lassa fever, Avian influenza (AI), and COVID-19 caused by SARS-CoV-2 urgently call for new strategies for the development of broad-spectrum antivirals targeting conserved components in the virus life cycle. Viral lipids are essential components, and viral-cell membrane fusion is the required entry step for most unrelated enveloped viruses. In this paper, we identified a porphyrin derivative of protoporphyrin IX (PPIX) that showed broad...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response</strong> - ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 susceptibility or severity, and the role of direct viral infection in brain cells remains obscure. We tested the neurotropism of SARS-CoV2 in human-induced pluripotent stem cell (hiPSC) models and observed low-grade infection of neurons and astrocytes that is boosted in neuron-astrocyte co-cultures and organoids. We then...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neutralizing Activity to SARS-CoV-2 of Convalescent and Control Plasma Used in a Randomized Controlled Trial</strong> - BACKGROUND: There are limited data on the neutralizing activity of convalescent plasma (CP) administered in randomized controlled trials (RCT) of COVID-19 infection.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome</strong> - Most children with COVID-19 have asymptomatic or mild illness. Those who become critically ill suffer from acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI). The rapid deterioration of lung function has been linked to microangiopathic and immune-mediated processes seen in the lungs of adult patients with COVID-19. The role of complement-mediated acute lung injury is supported by animal models of SARS-CoV, evaluation of lung tissue in those who died from COVID-19 and...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intravenous Immunoglobulin may Reverse Multisystem Inflammation in COVID-19 Pneumonitis and Guillain-Barre Syndrome</strong> - CONCLUSION: While the use of hyperimmune globulin requires a tedious job of collection from convalescent patients with verified and adequate titers, the use of IVIg could be an easier option to modulate the immune storm and faster recovery in SARS-CoV-2.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A proposed molecular mechanism for pathogenesis of severe RNA-viral pulmonary infections</strong> - Background: Certain riboviruses can cause severe pulmonary complications leading to death in some infected patients. We propose that DNA damage induced-apoptosis accelerates viral release, triggered by depletion of host RNA binding proteins (RBPs) from nuclear RNA bound to replicating viral sequences. Methods: Information theory-based analysis of interactions between RBPs and individual sequences in the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), Influenza A (H3N2), HIV-1, and...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system</strong> - The newly emerged severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) coronavirus initiated a pneumonia outbreak (COVID-19) that rapidly spread worldwide and quickly became a public health emergency of international concern; However to date, except Remdesivir, there are no clinically approved specific or effective medicines to prevent or treat COVID-19. Therefore, the development of novel treatments against coronavirus infections caused by the current SARS-CoV-2 virus, as well as other...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study</strong> - Kidneys are one of the targets for SARS-CoV-2, it is reported that up to 36% of patients with SARS-CoV-2 infection would develop into acute kidney injury (AKI). AKI is associated with high mortality in the clinical setting and contributes to the transition of AKI to chronic kidney disease (CKD). Up to date, the underlying mechanisms are obscure and there is no effective and specific treatment for COVID-19-induced AKI. In the present study, we investigated the mechanisms and interactions between...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5'-triphosphate exposure to support posology for SARS-CoV-2</strong> - CONCLUSION: This modelling approach has several important limitations that are discussed in the main text of the manuscript. However, the simulations indicate that despite rapid clearance of the parent drug from plasma, sufficient intracellular FAVI-RTP may be maintained across the dosing interval because of its long intracellular half-life. Population average intracellular FAVI-RTP concentrations are estimated to maintain the Km for the SARS-CoV-2 polymerase for 3 days following 800 mg BID...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fever, Diarrhea, and Severe Disease Correlate with High Persistent Antibody Levels against SARS-CoV-2</strong> - Lasting immunity will be critical for overcoming the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, factors that drive the development of high titers of anti-SARS-CoV-2 antibodies and how long those antibodies persist remain unclear. Our objective was to comprehensively evaluate anti-SARS-CoV-2 antibodies in a clinically diverse COVID-19 convalescent cohort at defined time points to determine if anti-SARS-CoV-2...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MVA Vector Vaccines Inhibit SARS CoV-2 Replication in Upper and Lower Respiratory Tracts of Transgenic Mice and Prevent Lethal Disease</strong> - Replication-restricted modified vaccinia virus Ankara (MVA) is a licensed smallpox vaccine and numerous clinical studies investigating recombinant MVAs (rMVAs) as vectors for prevention of other infectious diseases have been completed or are in progress. Two rMVA COVID-19 vaccine trials are at an initial stage, though no animal protection studies have been reported. Here, we characterize rMVAs expressing the S protein of CoV-2. Modifications of full length S individually or in combination...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 spike downregulates tetherin to enhance viral spread</strong> - The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae . Tetherin is an interferon-induced protein that forms parallel homodimers between the host cell and viral particles, linking viruses to the surface of infected cells and inhibiting their release. We demonstrate that SARS-CoV-2 downregulates tetherin to aid its release from cells, and investigate potential proteins involved in this process. Loss of...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4</strong> - Several studies have analyzed antiviral immune pathways in late-stage severe COVID-19. However, the initial steps of SARS-CoV-2 antiviral immunity are poorly understood. Here, we have isolated primary SARS-CoV-2 viral strains, and studied their interaction with human plasmacytoid pre-dendritic cells (pDC), a key player in antiviral immunity. We show that pDC are not productively infected by SARS-CoV-2. However, they efficiently diversified into activated P1-, P2-, and P3-pDC effector subsets in...</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU314054415">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313300659">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid 19 - Chewing Gum</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313269181">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19</strong> - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN313339294">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fahrzeuglüftungssystem und Verfahren zum Betreiben eines solchen Fahrzeuglüftungssystems</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Die Erfindung betrifft ein Fahrzeuglüftungssystem (1) zum Belüften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313868337">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251184">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251182">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN312324209">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mund-Nasen-Bedeckung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Mund-Nasen-Bedeckung (1), wobei die Mund-Nasen-Bedeckung (1) mindestens an einem Ohr eines Trägers magnetisch befestigbar ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313866760">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU311608060">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump’s Financial Troubles May Be Just Beginning</strong> - The President’s decision to attempt a “self-coup” came at what was already a fraught time for the Trump Organization. - <a href="https://www.newyorker.com/news/our-columnists/donald-trumps-financial-troubles-may-be-just-beginning">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Living in the Age of the White Mob</strong> - The attack on the Capitol shows that white riotous violence, brutally epitomized by the Tulsa Race Massacre, has never been relegated to history. - <a href="https://www.newyorker.com/news/dispatch/living-in-the-age-of-the-white-mob">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Trial of Donald Trump Must Tell the Full Story of the Capitol Insurrection</strong> - We need a truth-finding mission rather than just a punitive undertaking, and it requires the support of President-elect Biden. - <a href="https://www.newyorker.com/news/our-columnists/the-trial-of-donald-trump-must-tell-the-full-story-of-the-capitol-insurrection">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Reporter’s Footage from Inside the Capitol Siege</strong> - Luke Mogelson followed Trump supporters as they forced their way into the Senate chamber, using his phone’s camera as a reporter’s notebook. - <a href="https://www.newyorker.com/news/video-dept/a-reporters-footage-from-inside-the-capitol-siege">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Five Countries, Five Experiences of the Pandemic</strong> - Citizens from around the world share their coronavirus stories. - <a href="https://www.newyorker.com/science/medical-dispatch/five-countries-five-experiences-of-the-pandemic">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Capitol Police arrested an armed man at a DC security checkpoint</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/9bec5bCc7mVbqHsLOGVz7Wg4HJU=/661x0:6000x4004/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68679611/1230534105.0.jpg"/>
<figcaption>
The American flag flies at half mast in honor of Capitol Police officer Brian Sicknick, in Washington, DC. | Kent Nishimura/Los Angeles Times/Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A man with an unauthorized inauguration credential — and a handgun — was arrested by Capitol Police. He says it was a misunderstanding.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mv3uPd">
A man was arrested by US Capitol Police on Friday after officers found an unregistered gun and ammunition in his vehicle when he attempted to present what the department described as an unauthorized inauguration credential at a security checkpoint, according to <a href="https://www.cnn.com/politics/live-news/biden-inauguration-dc-capitol-news-01-16-21/h_1ac0f2630492cc82c96cc5c2cb16a07b">CNN</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4JmCJC">
However, the man who was arrested — a Virginian named Wesley Beeler — <a href="https://www.washingtonpost.com/nation/2021/01/16/capitol-protests-live-updates-inauguration-security/#link-EPGWV375D5DB3LXAJ4HTERL6XI">said Saturday</a> that he was merely on his way to work, and that his arrest was caused by what he called an “honest mistake.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iM9lBd">
The arrest came after Beeler was stopped at a security checkpoint, roughly half a mile away from the Capitol area. Beeler reportedly attempted to pass through the checkpoint using an unauthorized inauguration credential, and when officers checked a list of those allowed to be in the area, he wasn’t on it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hdAoiT">
After police stopped him, they reportedly searched his car and found a handgun, as well as 509 rounds of handgun ammunition and 21 shotgun shells. <a href="https://www.nytimes.com/2021/01/16/us/politics/man-arrested-dc-checkpoint.html">The New York Times</a> and CNN report that Beeler was asked whether he had a weapon in the vehicle, and that he told police he had a loaded Glock pistol in the truck’s center console. His truck also reportedly had multiple gun-related bumper decals.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bnRGiO">
“Beeler is charged with carrying a concealed weapon, possessing an unregistered firearm, unlawful possession of ammunition and possession of a large capacity ammunition feeding device,” <a href="https://www.nbcwashington.com/news/local/virginia-man-arrested-at-inauguration-checkpoint-with-unauthorized-credential-gun-police/2543951/">NBC Washington reports</a>. The gun Beeler had was not registered in DC, according to NBC Washington; in the District, possession of an unregistered firearm is illegal and subject to penalty.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V8HwxH">
On Saturday, Beeler’s father told the Times that his son was working on security with Capitol Police. An anonymous federal law enforcement official said that he was a contractor and that his credential was not fake, according to the paper. Beeler was authorized to have a firearm for his security work, but the gun was not registered in Washington, DC, the Times reported.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5IFP06">
After his release on Saturday, Beeler told the <a href="https://www.washingtonpost.com/nation/2021/01/16/capitol-protests-live-updates-inauguration-security/#link-EPGWV375D5DB3LXAJ4HTERL6XI">Washington Post</a> he’d neglected to take his firearm out of his vehicle because he had been running late for work; he told the paper he works with MVP Protective Services, and that that company gave him the inauguration credentials that were rejected by the security forces.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cpNAGw">
“I pulled up to a checkpoint after getting lost in DC because I’m a country boy,” Beeler said. “I showed them the inauguration badge that was given to me.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pL3uyt">
Beeler added, “I don’t know what the DC laws are. It still comes back on me, but I’m not a criminal.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8YntGS">
The arrest comes as security in Washington, DC, ramps up in anticipation for the January 20 inauguration of President-elect Joe Biden. Normal inauguration security has been even more robust than usual in the wake of the violent attack of the Capitol on January 6. <a href="https://www.vox.com/2021/1/15/22233623/national-guard-capitol-secret-service-fbi-washington-dc">As Vox’s Alex Ward reported,</a> as many as 25,000 National Guard members will be stationed in Washington for the event, in addition to thousands of police and Secret Service members.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W0bTFJ">
The Secret Service has also worked with local officials to facilitate a large number of street closures, according to the <a href="https://www.washingtonpost.com/dc-md-va/2021/01/15/ahead-inauguration-much-dc-closed-off-like-never-before/?arc404=true">Washington Post</a>, dividing the area around the White House, National Mall, and the Capitol into “red” and “green” zones. In the red zones, which encircle federal buildings and national monuments, traffic is limited to authorized vehicles; in the green zones surrounding these red zones, resident and business traffic is allowed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6P52rO">
Law enforcement officers have been on high alert for additional violence after pro-Trump rioters stormed the Capitol in a mob attack on the building that led to five deaths. The FBI has also raised warnings about potential demonstrations at state capitols — and the US Capitol — leading up to Inauguration Day next Wednesday.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Fu5nUE">
Officials are looking back as well: Four House committees have now opened an investigation into why security failed to block rioters from breaking into the Capitol, <a href="https://www.vox.com/2021/1/16/22234785/house-democrats-launch-investigation-into-capitol-riot-security-failures">as Vox’s Aaron Rupar reported</a>. Through the checkpoints and troop presence, law enforcement hopes to prevent a similar attack from happening again.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G4Hzh3">
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Poll: Most Republicans believe Trump bears no responsibility for Capitol attacks</strong> -
<figure>
<img alt="A mass of people cover the Capitol steps and the spaces between its columns; many have on red MAGA hats; still more wave blue flags bearing Trump’s name in white." src="https://cdn.vox-cdn.com/thumbor/I99nk8x1BrREjwdudjXTmdiVkC8=/312x0:5304x3744/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68679619/GettyImages_1230477154.0.jpg"/>
<figcaption>
Trump flags fly as supporters of President Donald Trump occupy the steps of the US Capitol. | Shay Horse/NurPhoto/Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A new poll finds a nation united on opposing the Capitol attacks but divided on who is to blame.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Mv4pu">
An overwhelming majority of Americans disapprove of the storming of the US Capitol on January 6, but most Republicans say President Donald Trump bears no responsibility for the assault — and nearly half say Republican lawmakers didn’t go far enough in supporting the president’s efforts to overturn the election’s results, according to a new <a href="https://www.washingtonpost.com/politics/trump-poll-post-abc/2021/01/14/aeac7b96-5690-11eb-a817-e5e7f8a406d6_story.html">Washington Post-ABC News poll</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sqtrxC">
The poll — which surveys 1,002 US adults, and was taken from January 10 to 13 — paints a striking picture, and finds a national consensus on the impropriety of what transpired at the Capitol, while revealing familiar divisions on who is to blame for the episode.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ISobPL">
The poll found that almost 9 in 10 Americans oppose the storming of the Capitol, and that 80 percent strongly oppose the attack.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OnkEeA">
But the country’s divisions are apparent in questions on who is to blame — and what, if any, repercussions Trump should face for <a href="https://www.reuters.com/article/us-usa-election-protests/trump-summoned-supporters-to-wild-protest-and-told-them-to-fight-they-did-idUSKBN29B24S">promoting a “wild” rally</a> that eventually overran the country’s legislature and resulted in the deaths of five people.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="O7bVom">
While majorities of the public disapprove of the president’s behavior, Trump still retains a large, if somewhat diminished, degree of support from Republicans, as does his disinformation campaign to discredit the 2020 election results.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aOlZNw">
The poll found 56 percent of Americans believe that Congress should remove Trump from office and prevent him from holding elected office in the future. But among Republicans, 89 percent oppose such a course of action.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P8jvBq">
The reason for that appears to be straightforward: The pollsters found most Republicans don’t think he did anything wrong.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="a1xQin">
While 66 percent of Americans believe Trump has acted irresponsibly in his statements and actions since the election, 66 percent of Republicans think he acted responsibly, according to the poll.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gi9LJ3">
And while 57 percent of Americans believe Trump bears a great deal or good amount of responsibility for the violent attack, 56 percent of Republicans say Trump bears no responsibility — and another 22 percent say he bears some.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Sn7k59">
A large percentage of Republicans also feel GOP leaders should in fact have gone further in their efforts to back Trump’s bid to overturn the election results. While 52 percent of Americans believe GOP leaders went too far in supporting Trump’s false claims about the election results, 48 percent of Republicans said they did not go far enough.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jnaTya">
A similar divide is also apparent in the poll’s results on whether Trump should be held legally liable for the attack. Most Americans think he should be criminally charged for his role; only 1 in 8 Republicans agree.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7VDJHg">
These findings of Republicans as reluctant to assign blame to Trump match trends in other surveys. As Vox’s Sean Collins wrote in <a href="https://www.vox.com/2021/1/10/22222094/trump-impeachment-polls-capitol-hill-riots">an analysis</a> of polling conducted immediately after the Capitol Hill attack, considerable portions of Republicans are inclined to believe that the riot was not only not Trump’s fault, but actually something Democrats should be blamed for.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8FTkLj">
“Instead of placing the insurrection at Trump’s feet, 52 percent of Republicans told <a href="https://docs.cdn.yougov.com/7e6digtwqp/capitol-protest-crosstabs-adobe.pdf">YouGov</a> that it was actually Biden’s fault; 42 percent of Republicans told <a href="https://assets.morningconsult.com/wp-uploads/2021/01/07135439/210121_crosstabs_POLITICO_RVs_v1.pdf">Morning Consult</a> the same — and 48 percent of Republicans told Morning Consult that Democrats in Congress were also to blame,” Collins wrote last week.
</p>
<h3 id="amB5XZ">
Trump’s support has dropped sharply, but hasn’t collapsed
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DKxKlP">
There are, however, signs that a significant set of Republicans are skeptical that Trump is the right leader for their party going forward. According to the new Washington Post-ABC News poll, fewer than six in 10 Republicans and Republican-leaning independents say party leaders should follow Trump’s lead in the future, while 35 percent say they should move away from Trump — “a sentiment that has roughly doubled from 18 percent in 2018.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sFxNfE">
As <a href="https://projects.fivethirtyeight.com/trump-approval-ratings/?ex_cid=rrpromo">FiveThirtyEight’s approval poll tracker</a> shows, Trump’s support had one of the biggest drops of his presidency after the attack, and he has reached the lowest level of support in his tenure, at an average of about 38 percent approval and 58 percent disapproval. A shift in Republicans’ views <a href="https://www.vox.com/2021/1/15/22232847/poll-trump-approval-29-percent-republicans-support-collapsing-impeachment">accounts for much of the drop</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nABPLc">
Conservatives’ lingering commitment to Trump poses significant dilemmas for Republicans after Trump leaves office. Of late, Trump has taken a somewhat <a href="https://www.vox.com/2021/1/6/22217203/trump-ellipse-speech-primary-republicans-overturn-the-election-pence">adversarial stance against certain segments of his party</a>, threatening to back the primary opponents of lawmakers he does not like. Establishment Republicans are worried that a Trump-fueled split in the party could damage their prospects as they prepare for midterm elections.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AN04Pi">
And some Republican lawmakers find Trump’s political style unpredictable, overly transgressive of political norms, and a distraction from their policy agenda. This is reportedly part of why Senate Majority Leader Mitch McConnell is said to be contemplating voting to <a href="https://www.axios.com/mcconnell-trump-convict-impeachment-trial-99246975-8c02-47f4-90d3-14a23c00afd1.html">convict Trump in a Senate impeachment trial</a> and why some Republicans are <a href="https://www.nytimes.com/2021/01/16/us/politics/republicans-trump-leadership.html">already working to defeat Trump-style candidates in the 2022 elections.</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bFJcl9">
But, as this poll demonstrates, Trump still has the enthusiastic support of many in the GOP. Regardless of how top lawmakers in the party may view him, they could risk alienating their own base if they try to move too far away from him, or sanction him.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Qez1eZ">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5QpRno">
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Trump administration’s execution of Dustin Higgs, explained</strong> -
<figure>
<img alt="A white, cylindrical prison guard tower rises from a green lawn amid a mass of white buildings. In the foreground is a white sign with blue text, reading: Federal Bureau of Prisons Federal Correctional Complex, Terre Haute. " src="https://cdn.vox-cdn.com/thumbor/QAL7-afT7X30o1eNB8oR5KBWsfI=/321x0:5412x3818/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68679553/AP_20324418769081.0.jpg"/>
<figcaption>
The federal prison complex in Terre Haute, Indiana where Dustin Higgs was executed. | Michael Conroy/AP
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Higgs was the 13th federal prisoner executed since July 2020.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Fll4qa">
In the early hours of Saturday morning, the Trump administration executed Dustin Higgs for taking part in a triple murder in Maryland in 1996, a crime of which he claimed to be innocent, including with his final words.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fbynWR">
Higgs’s execution was the 13th, and final, federal execution carried out by the Trump administration over the course of six months, a run which has broken starkly with modern precedent both in terms of speed and intensity: The federal government has carried out more federal executions since last summer than in the last <a href="https://theintercept.com/2020/12/05/federal-executions-brandon-bernard/">67 years combined.</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ii6RbI">
The Trump administration has argued that the executions were conducted as a matter of law, noting that all of those executed were found guilty at trial. “If you ask juries to impose and juries impose it, then it should be carried out,” former Trump administration Attorney General Bill Barr, told the <a href="https://apnews.com/article/donald-trump-death-penalty-legacy-838932ac2b665b42373309336d130f56">Associated Press</a> days before his <a href="https://www.vox.com/2020/12/14/22175221/bill-barr-resigns-trump-attorney-general">resignation in December</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YwBSL7">
But many criminal justice advocates — and some members of the Supreme Court — <a href="https://twitter.com/jessicaschulb/status/1350330850013941760/photo/1">have argued</a> that the schedule has been rushed in a way that neglected appropriate deliberation of the legality of the killings, and that they unfairly targeted people of color, as well as, people suffering from severe trauma.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oYZdyL">
And some legal analysts note that Higgs’ execution was enabled by the Supreme Court through a maneuver that they describe as a transparent bid to facilitate Trump’s agenda.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3RLnsp">
Higgs was <a href="https://www.justice.gov/opa/pr/executions-scheduled-inmates-convicted-brutal-murders-many-years-ago">found guilty</a> in 2000 of first-degree premeditated murder, three counts of first-degree felony murder, and three counts of kidnapping resulting in death. The Justice Department <a href="https://www.cnn.com/2021/01/16/us/dustin-higgs-executed/index.html">said</a> that in 1996 Higgs traveled with two male friends and three women to a Maryland wildlife refuge, and ordered one of his friends to shoot the three women, one of whom had allegedly rebuffed an advance by him.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lwzKBE">
Higgs has said he is innocent of the crime, and that he gave no order for a killing. His friend who fired the shots who is serving a life sentence, Willis Haynes, <a href="https://www.vox.com/21736993/trump-federal-execution-december">has disputed </a>the prosecutions’ argument that Higgs coerced him into the act in a signed affidavit, <a href="https://go.redirectingat.com/?id=66960X1516588&amp;xs=1&amp;url=https://vimeo.com/194702182&amp;referrer=vox.com&amp;sref=https://www.vox.com/21736993/trump-federal-execution-december&amp;xcust=___vx__e_21501034__r_google.com__t_w__d_D" rel="sponsored nofollow noopener" target="_blank">saying</a>, “The prosecution’s theory of our case was bullshit. Dustin didn’t threaten me. I was not scared of him. Dustin didn’t make me do anything that night or ever.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1Pq0nW">
Higgs <a href="https://www.cnn.com/2021/01/16/us/dustin-higgs-executed/index.html">reportedly</a> claimed innocence again in his final words. “I’d like to say I am an innocent man. ... I am not responsible for the deaths,” <a href="https://apnews.com/article/donald-trump-wildlife-coronavirus-pandemic-crime-terre-haute-28e44cc5c026dc16472751bbde0ead50">he said</a>, while mentioning the names of the victims. “I did not order the murders.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2OdyvD">
Higgs was diagnosed with Covid-19 before the execution, and his attorney <a href="https://www.npr.org/2021/01/16/957559566/u-s-executes-dustin-higgs-in-13th-and-final-execution-under-trump-administration">had attempted</a> to delay the execution on the basis that it was cruel, because of concerns that the virus might intensify the lethal injection of pentobarbital. Also at issue was whether Higgs could be executed in Indiana, where he was being held, after being sentenced in Maryland using a death penalty law that no longer exists.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6CUAsQ">
The execution went forward anyway. Higgs was given a lethal injection at the federal penitentiary in Terre Haute, Indiana, and pronounced dead at 1:23 am on Saturday morning.
</p>
<h3 id="kqxv05">
The Supreme Court appears to have acted extraordinarily to back Trump
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PGjCIk">
A number of legal analysts have described the Supreme Court’s handling of Higgs’ execution as “<a href="https://slate.com/news-and-politics/2021/01/dustin-higgs-supreme-court-death-penalty-sotomayor.html">unprecedented”</a> and “beyond extraordinary.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AegF3N">
Slate’s legal writer Mark Joseph Stern <a href="https://slate.com/news-and-politics/2021/01/dustin-higgs-supreme-court-death-penalty-sotomayor.html">explained</a> that with Higgs, the high court ended up circumventing the traditional appeals process in order to swiftly provide legal backing to Trump’s order to proceed with the execution despite questions about Higgs’s sentencing before he left office:<strong> </strong>
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rdB0pd">
Federal law requires a federal death sentence to be implemented “in the manner prescribed” by the state in which it was imposed. But Higgs was sentenced by a federal court in Maryland, which abolished capital punishment in 2013, so there is no “manner prescribed” for Higgs’ execution. An appeals court upheld the district court’s stay, setting oral arguments for Jan. 27. On Jan. 11, Trump’s Department of Justice <a href="https://www.supremecourt.gov/DocketPDF/20/20-927/165914/20210111163854803_United%20States%20v.%20Higgs%20Petition%20for%20Cert%20Before%20Judgment.pdf">asked</a> the Supreme Court to clear away these roadblocks. In a stunning move, the court agreed: It issued a summary decision on the merits of the case, short-circuiting the traditional appeals process.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="71LZYT">
The <a href="https://www.supremecourt.gov/opinions/20pdf/20-927_i42k.pdf#page=1">Supreme Court’s 6-3 vote</a>, in which the liberal wing of the court voted against the decision to clear the way for the execution, was accompanied by a blistering dissent from Justice Sonia Sotomayor.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5OjjAx">
“This is not justice,” Sotomayor <a href="https://www.nytimes.com/2021/01/16/us/politics/dustin-higgs-executed.html">wrote</a> in her dissent, arguing that the high court was not fulfilling its duty to deliberative process in green-lighting the act <strong>— </strong>and that it had similarly failed to do so with respect to the 12 executions prior to Higgs’. “After waiting almost two decades to resume federal executions, the government should have proceeded with some measure of restraint to ensure it did so lawfully. When it did not, this court should have. It has not.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bkFFWL">
Justice Stephen Breyer, argued that the Court had been negligent in considering the constitutionality of the executions, and that it had particularly failed in its duty to unusual issues, such as how the pandemic might affect the legality of executions. In <a href="https://www.supremecourt.gov/opinions/20pdf/20-927_i42k.pdf#page=1">his dissent</a>, he asked, “How just is a legal system that would execute an individual without consideration of a novel or significant legal question that he has raised?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HciDV8">
Jaime Santos, a partner at Goodwin Procter’s appellate litigation practice, <a href="https://twitter.com/Jaime_ASantos/status/1350304015393894403">described</a> the ruling as “a political decision, not a doctrinal one and not one that is in any way consistent with the norms and precedents governing Supreme Court practice.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Re4FY6">
It is decisions such as these that have led observers like Vox’s Ian Millhiser to describe a conservative majority court as an “anti-democratic threat.”<strong> </strong>And Santos’s comments underscore concerns that the Supreme Court has become an institution that often privileges conservative political goals over traditional process.
</p>
<h3 id="lx2o0c">
Trump’s capital punishment agenda
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0sycS1">
Higgs’s death marks the end of a remarkably focused program of conducting federal executions that critics of capital punishment have deemed <a href="https://www.theatlantic.com/ideas/archive/2021/01/trump-putting-machinery-death-overdrive/617682/">“a killing spree.”</a> Strikingly, the federal executions were conducted amid a pandemic that drastically shrunk the<a href="https://www.latimes.com/opinion/story/2020-12-16/covid-executions-prison-capital-punishment"> number of executions carried out on the state level</a>, and in the wake of a racial justice movement critical of an overly punitive criminal justice system.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pDTgaP">
Experts say Trump’s emphasis on capital punishment in his final half-year in office marked a sharp departure from federal government norms, a trend which stands out all the more because support for the death penalty is at <a href="https://news.gallup.com/poll/312929/record-low-say-death-penalty-morally-acceptable.aspx">the lowest</a> its been in decades.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1awLQa">
“No one has conducted this number of federal civilian executions in this short period of time in American history,” Robert Dunham, executive director of Death Penalty Information Center, <a href="https://www.vox.com/21736993/trump-federal-execution-december">told Vox in December</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WjfYBf">
The uptick in federal executions also stood out in a year where capital punishment was used less than it had been in decades at the state level, largely due to pandemic-related slowdowns and shutdowns of the criminal justice system.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TLiGNB">
“The fact that we’re having a record-high number of federal executions, at the same time that we’re near a record low in state executions, in the middle of a pandemic, shows how much the Trump administration is either out of touch or that it cannot resist gratuitous acts of cruelty,” Dunham told Vox in December.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7wuhyz">
The Trump administration has routinely defended its use of capital punishment. For instance, Barr <a href="https://www.justice.gov/opa/pr/federal-government-resume-capital-punishment-after-nearly-two-decade-lapse">described</a> the Trump administration’s commitment to the death penalty as carrying out the punishment against “the worst criminals.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RjulHb">
But as the ACLU <a href="https://twitter.com/jessicaschulb/status/1350330850013941760/photo/1">points out</a>, many of those executed don’t tick off the conventional boxes for “worst criminals”:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e7oJBQ">
Our federal government killed two Black men for crimes they committed 20 years ago as teenagers; it killed a woman who was a victim of unthinkable sexual violence and torture; it killed two Black men who didn’t kill anyone; and a man with an intellectual disability so severe that it’s impossible to ignore in his final words. The Supreme Court paved the way for many of these executions to go forward despite lower court findings that the executions were unconstitutional or barred by federal law.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ubwPTv">
Beyond seeking to revive and expedite the use of capital punishment, the Trump administration also expanded the way that it can be carried out. Last year the Justice Department <a href="https://www.nytimes.com/2020/11/25/us/politics/executions-firing-squads-electrocution.html">created</a> and finalized a rule that allows the government to use more ways to kill prisoners, including electrocution and firing squad.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rqhzCY">
But while the revival of federal capital punishment has been a signature feature of Trump’s political and policy agenda, it is not clear to what extent it will be part of his legacy. President-elect Joe Biden <a href="https://www.npr.org/2020/12/30/950105746/end-this-cruelty-progressives-call-on-biden-to-work-to-stop-executions">has said he will work to abolish</a> the federal death penalty, and Senate Democrats recently put out <a href="https://www.npr.org/2021/01/11/955693696/democrats-unveil-legislation-to-abolish-the-federal-death-penalty">legislation </a>that would abolish it.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs India | Washington-Shardul partnership was outstanding: Ricky Ponting</strong> - Washington (62) and Shardul (67) led a splendid lower-order fightback after India were reduced to 186 for 6 in reply to Australia's 369</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Winning over Aussie crowd was Shardul Thakur’s inspiration behind gritty knock</strong> - Thakur (67) joined hands with debutant Washington Sundar (62) for a combative 123-run seventh wicket stand.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aus vs Ind fourth Test | Shardul, Washington batted brilliantly; we faltered in execution, says Hazlewood</strong> - Hazlewood conceded that Australia let a few moments slip in the day, which could have eventually made the difference.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aus vs Ind fourth Test | Washington Sundar, Shardul Thakur keep India in contention</strong> - Australia now leads by 54 runs after India's first innings ended at 336.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australian Open to plough ahead despite players' quarantine anger</strong> - Forty-seven players and their entourages have to isolate for two weeks in Melbourne in their hotel rooms and no longer be able to leave them to train after three coronavirus infections were reported on two chartered flights carrying them to Melbourne.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trinamool leaders in Bengal received COVID vaccine shots meant for health workers: BJP</strong> - Several Trinamool leaders, including two MLAs, were among the people who received the COVID-19 vaccine in Purba Bardhaman district on Saturday</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mahesh Manjrekar booked for assault</strong> - Film-maker allegedly slapped and abused a man for road accident in Pune</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aero India 2021 next month will showcase a range of indigenously developed helicopters</strong> - Conclave of Defence Ministers from the Indian Ocean Littoral (IOR) states also to take place</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Election Commission team to visit Assam from January 18 to review poll preparedness</strong> - The CEC will hold separate meetings with senior officials of the state government, including the chief secretary, home secretary, director general of police, chief electoral officer and police nodal officer.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Legendary classical musician Ustad Ghulam Mustafa Khan dies at 89</strong> - His family said the demise was unexpected as the Padma Bhushan awardee had been keeping well.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Armin Laschet elected leader of Merkel's CDU party</strong> - Centrist Armin Laschet is now in a good position to succeed Angela Merkel as Germany's chancellor.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The man startling millions of starlings with lasers</strong> - During starling season in winter, up to four million of the birds descend on Rome, covering streets and vehicles with their droppings.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fighting for the Parthenon marbles</strong> - In the 1980s Greece demanded Britain return the Parthenon marbles, a sculptural frieze removed by Lord Elgin almost two hundred years earlier.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: EU anger over delayed Pfizer vaccine deliveries</strong> - Many EU countries are receiving significantly fewer doses due to a change in manufacturing processes.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dutch Rutte government resigns over child welfare fraud scandal</strong> - Mark Rutte's cabinet resigns after families were wrongly accused and many faced financial problems.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AI-powered text from this program could fool the government</strong> - Volunteers couldn't tell AI-generated comments from those penned by humans. - <a href="https://arstechnica.com/?p=1735534">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>After a decade, NASA’s big rocket fails its first real test</strong> - "It's not everything we hoped it would be." - <a href="https://arstechnica.com/?p=1735435">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What motivates the motivated reasoning of pro-Trump conspiracists?</strong> - New study suggests a desire to see society focus on men helps drive support. - <a href="https://arstechnica.com/?p=1735619">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The local politics of AirBNB’s ban on DC rentals</strong> - Traumatized residents, city officials fear a repeat of January 6 insurrection. - <a href="https://arstechnica.com/?p=1735519">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hackers alter stolen regulatory data to sow mistrust in COVID-19 vaccine</strong> - Post titled “Astonishing fraud! Evil Pfffizer! Fake vaccines!” found on the dark Web. - <a href="https://arstechnica.com/?p=1735585">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Why is the National Rifle Association filing for bankruptcy?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Because schools are closed.
</p>
</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/dawsomm"> /u/dawsomm </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kyu2cf/why_is_the_national_rifle_association_filing_for/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kyu2cf/why_is_the_national_rifle_association_filing_for/">[comments]</a></span></p></li>
<li><strong>My wife found out I was cheating on her after she found all the letters I was hiding!</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She got mad and said she is never playing Scrabble with me again!
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/testturkey"> /u/testturkey </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kyxbzp/my_wife_found_out_i_was_cheating_on_her_after_she/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kyxbzp/my_wife_found_out_i_was_cheating_on_her_after_she/">[comments]</a></span></p></li>
<li><strong>A Russian joke my grandmother once told me. I hope it works in English.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A man sits at the deathbed of his mother-in-law. She suffers very much and cries in agony: "Oh I'm dying!" "It hurts" "I'm gonna die soon" She stops for a seconds and says: "Well at least the weather is nice today"
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man says: "hey dear, don't get distracted!"
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Cantimetrik"> /u/Cantimetrik </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kyt6mp/a_russian_joke_my_grandmother_once_told_me_i_hope/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kyt6mp/a_russian_joke_my_grandmother_once_told_me_i_hope/">[comments]</a></span></p></li>
<li><strong>A young man goes into a drug store to buy condoms.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The pharmacist says the condoms come in packs of 3, 9 or 12 and asks which the young man wants. "Well," he said, "I've been seeing this girl for a while and she's really hot. I want the condoms because I think tonight's "the" night. We're having dinner with her parents, and then we're going out, and I've got a feeling I'm gonna get lucky after that. Once she's had me, she'll want me all the time, so you'd better give me the 12 pack." The young man makes his purchase and leaves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Later that evening, he sits down to dinner with his girlfriend and her parents. He asks if he might give the blessing, and they agree. He begins the prayer, but continues praying for several minutes. The girl leans over and says, "You never told me that you were such a religious person."
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He leans over to her and says, "You never told me that your father is a pharmacist."
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Prismeus"> /u/Prismeus </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kz3k90/a_young_man_goes_into_a_drug_store_to_buy_condoms/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kz3k90/a_young_man_goes_into_a_drug_store_to_buy_condoms/">[comments]</a></span></p></li>
<li><strong>Three friends are in a hotel room in Soviet Russia.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The first two men open a bottle of vodka, while the third is tired and goes straight to bed. He is unable to sleep however, as his increasingly drunk friends tell political jokes loudly.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After a while, the tired man gets frustrated and walks downstairs for a smoke. He stops in the lounge and asks the receptionist to bring tea to their room in five minutes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man walks back into the room, joins the table, leans towards a power outlet and speaks into it:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
"Comrade major, we want some tea to room 62 please."
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His friends laugh on the joke, until there is a knock on the door. The receptionist brings a teapot. His friends fall silent and pale, horrified of what they just witnessed. The party is dead, and the man goes to sleep.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After a good night's rest, the man wakes up, and notices his friends are gone. Surprised, he walks downstairs and asks the receptionist where they went.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The nervous receptionist whispers that KGB came and took them before dawn.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man is horrified. He wonders why he was spared.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The receptionist responds:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
"Well, comrade major did quite like your tea joke."
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/taloncard815"> /u/taloncard815 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kyl7mp/three_friends_are_in_a_hotel_room_in_soviet_russia/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kyl7mp/three_friends_are_in_a_hotel_room_in_soviet_russia/">[comments]</a></span></p></li>
</ul>
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