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+ + + +Supervised Computerized Active Program for People With Post-COVID Syndrome (SuperCAP Study) - Conditions: Post-COVID Condition
Interventions: Device: SuperCAP Program
Sponsors: Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia; Institut de Recerca de la SIDA IrsiCaixa; Germans Trias i Pujol Hospital
Recruiting
Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19 - Conditions: Long COVID
Interventions: Diagnostic Test: RNA Biomarker Blood Test
Sponsors: MaxWell Clinic, PLC
Recruiting
Home-Based Circuit Training in Overweight/Obese Older Adult Patients With Knee Osteoarthritis and Type 2 Diabetes - Conditions: Aerobic Exercise; Strength Training; Glycemic Control; Blood Pressure; Oxidative Stress; Metabolic Syndrome
Interventions: Behavioral: 12-week home-based circuit training (HBCT); Behavioral: Standard of care (CONT)
Sponsors: Princess Nourah Bint Abdulrahman University
Completed
RECOVER-AUTONOMIC Platform Protocol - Conditions: Long COVID; Long Covid19; Long Covid-19
Interventions: Drug: IVIG + Coordinated Care; Drug: IVIG Placebo + Coordinated Care; Drug: Ivabradine + Coordinated Care; Drug: Ivabradine Placebo + Coordinated Care; Drug: IVIG + Usual Care; Drug: IVIG Placebo + Usual Care; Drug: Ivabradine + Usual Care; Drug: Ivabradine Placebo + Usual Care
Sponsors: Kanecia Obie Zimmerman
Enrolling by invitation
SVF for Treating Pulmonary Fibrosis Post COVID-19 - Conditions: Pulmonary Fibrosis
Interventions: Biological: Autologous adipose-derived SVF IV administration
Sponsors: Michael H Carstens; Ministerio de Salud de Nicaragua; Wake Forest University; National Autonomous University of Nicaragua
Completed
RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG) - Conditions: Long COVID; Long Coronavirus Disease 2019 (Covid19); Long Covid-19
Interventions: Drug: IVIG (intravenous immunoglobulin); Drug: IVIG Placebo; Behavioral: Coordinated Care; Behavioral: Usual Care
Sponsors: Kanecia Obie Zimmerman
Not yet recruiting
RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine) - Conditions: Long COVID; Long Covid19; Long Covid-19
Interventions: Drug: Ivabradine; Drug: Ivabradine Placebo; Behavioral: Coordinated Care; Behavioral: Usual Care
Sponsors: Kanecia Obie Zimmerman
Enrolling by invitation
Understanding Adaptive Immune Response After COVID-19 Vaccination Boosters to Improve Vaccination Strategies in Vulnerable Groups. - Conditions: COVID-19
Interventions: Other: Analisys of cellular response and humoral response to SARS-CoV-2 vaccine booster doses
Sponsors: IRCCS Sacro Cuore Don Calabria di Negrar
Recruiting
COVIDVaxStories: Randomized Trial to Reduce COVID-19 Vaccine Hesitancy in Populations of Color - Conditions: Vaccine Hesitancy
Interventions: Behavioral: Storytelling; Behavioral: Learn More (Active Comparator)
Sponsors: University of Massachusetts, Worcester; Merck Sharp & Dohme LLC
Recruiting
An E-health Psychoeducation for People With Bipolar Disorders - Conditions: Bipolar Disorder; Psychoeducation; COVID-19 Pandemic
Interventions: Other: e-health psychoeducation
Sponsors: University of Cagliari; Alessandra Perra
Completed
Sulfureous Water Therapy in Viral Respiratory Diseases - Conditions: Long-COVID; Post COVID-19 Condition; Chronic COVID-19 Syndrome; Post Acute Sequelae of COVID-19
Interventions: Other: Inhalation of Sulfurous Thermal Water; Other: Inhalation of Sterile Distilled non-pyrogenic Water
Sponsors: University of Roma La Sapienza; Università degli studi di Roma Foro Italico; Queen Mary University of London; Bios Prevention Srl
Completed
Phase 3 Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine - Conditions: COVID-19
Interventions: Biological: CIC Vaccine Co-formulated tNIV2 , SARSCoV-2 rS and Matrix-M Adjuvant; Biological: Novavax COVID-19 Vaccine; Biological: Comparator Influenza Vaccine - Fluarix; Biological: Comparator Influenza Vaccine -Fluarix High Dose; Biological: Placebo 0.9% sodium chloride for injection
Sponsors: Novavax
Not yet recruiting
Evaluation of KGR Prescriptions in Suppressing COVID-19 Infection. - Conditions: Coronavirus Disease 2019; Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Interventions: Combination Product: Kang Guan Recipe (Treat); Combination Product: Kang Guan Recipe (Placebo)
Sponsors: Sheng-Teng Huang
Completed
Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2 - The urgent need for effective treatments against emerging viral diseases, driven by drug-resistant strains and new viral variants, remains critical. We focus on inhibiting the human dihydroorotate dehydrogenase (HsDHODH), one of the main enzymes responsible for pyrimidine nucleotide synthesis. This strategy could impede viral replication without provoking resistance. We evaluated naphthoquinone fragments, discovering potent HsDHODH inhibition with IC(50) ranging from 48 to 684 nM, and promising…
Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae - By largely unknown mechanism(s), SARS-CoV-2 hijacks the host translation apparatus to promote COVID-19 pathogenesis. We report that the histone methyltransferase G9a noncanonically regulates viral hijacking of the translation machinery to bring about COVID-19 symptoms of hyperinflammation, lymphopenia, and blood coagulation. Chemoproteomic analysis of COVID-19 patient peripheral mononuclear blood cells (PBMC) identified enhanced interactions between SARS-CoV-2-upregulated G9a and distinct…
Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses - Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-converting enzyme 2 (sACE2) might mask the spike and interfere with antibody maturation toward the SARS-CoV-2-receptor-binding motif (RBM). We tested 717 longitudinal samples from 295 COVID-19 patients and showed a 2- to 10-fold increase of enzymatically active…
Evaluating Critical Thinking Disposition, Emotional Intelligence, and Learning Environment of Nursing Students: A Longitudinal Study - CONCLUSIONS: Critical thinking and emotional intelligence did not change, but students favored the online learning environment over the traditional. These findings suggest that nurse educators persevered, adapted, and maintained the quality of the learning environment despite the pandemic. Moreover, the utilization of an online learning environment may have led to enhanced enjoyment and engagement for students, which could potentially result in improved learning outcomes.
Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement - CONCLUSION: The micro-sized inclusion cocrystals AA/γCD were successfully delivered into the lungs by pulmonary administration and had a significant therapeutic effect on ALI.
Thai traditional medicines reduce CD147 levels in lung cells: Potential therapeutic candidates for cancers, inflammations, and COVID-19 - CONCLUSIONS: UMD and UMM are potential for reduction of CD147 levels which provide a useful information for further development of UM as potential therapeutic candidates for CD147-associated diseases such as cancers, inflammations, and COVID-19.
Design, synthesis, and antiviral activity of 1-aryl-4-arylmethylpiperazine derivatives as Zika virus inhibitors with broad antiviral spectrum - Zika virus (ZIKV) disease has been given attention due to the risk of congenital microcephaly and neurodevelopmental disorders after ZIKV infection in pregnancy, but no vaccine or antiviral drug is available. Based on a previously reported ZIKV inhibitor ZK22, a series of novel 1-aryl-4-arylmethylpiperazine derivatives was designed, synthesized, and investigated for antiviral activity by quantify cellular ZIKV RNA amount using RT-qPCR method in ZIKV-infected human venous endothelial cells…
A combination of nirmatrelvir and ombitasvir boosts inhibition of SARS-CoV-2 replication - Antiviral therapeutics are highly effective countermeasures for the treatment of coronavirus disease 2019 (COVID-19). However, development of resistance to antivirals undermines their effectiveness. Combining multiple antivirals during patient treatment has the potential to overcome the evolutionary selective pressure towards antiviral resistance, as well as provide a more robust and efficacious treatment option. The current evidence for effective antiviral combinations to inhibit severe acute…
Novel nitric oxide donors are coronary vasodilators that also bind to the papain-like protease of SARS-CoV-2 - Several investigational nitric oxide donors were originally created to correct vascular endothelial dysfunction in cardiovascular diseases. These 48 compounds contain an urea-like moiety attached to the well-known NO donors isosorbide 2- and 5-mononitrate. CR-0305 and CR-0202 were synthesized and found to be nontoxic in the cell lines HMEC-1, A549/hACE2 and VeroE6. CR-0305 induced vasodilation in human coronary arteries ex vivo. Since NO can also have antiviral properties, a study of…
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity - G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibits stress granule assembly and interacts with G3BP1/2 via an ITFG motif, including residue F17, in the N protein. Prior studies examining the impact of the G3PB1-N interaction on SARS-CoV-2 replication have produced inconsistent findings, and the role of this…
Eucalyptus Oils Phytochemical Composition in Correlation with Their Newly Explored Anti-SARS-CoV-2 Potential: in Vitro and in Silico Approaches - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest arisen contagious respiratory pathogen related to the global outbreak of atypical pneumonia pandemic (COVID-19). The essential oils (EOs) of Eucalyptus camaldulensis, E. ficifolia F. Muell., E. citriodora Hook, E. globulus Labill, E. sideroxylon Cunn. ex Woolls, and E. torquata Luehm. were investigated for its antiviral activity against SARS-CoV-2. The EOs phytochemical composition was determined using GC/MS analysis….
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex - Coronaviruses contain one of the largest genomes among the RNA viruses, coding for 14-16 non-structural proteins (nsp) that are involved in proteolytic processing, genome replication and transcription, and four structural proteins that build the core of the mature virion. Due to conservation across coronaviruses, nsps form a group of promising drug targets as their inhibition directly affects viral replication and, therefore, progression of infection. A minimal but fully functional replication…
Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization - Corona Virus Disease 2019 (COVID-19) is an infectious disease that seriously endangers human life and health. The pathological anatomy results of patients who died of the COVID-19 showed that there was an excessive inflammatory response in the lungs. It is also known that most of the COVID-19 infected patients will cause different degrees of lung damage after infection, and may have pulmonary fibrosis remaining after cure. Macrophages are a type of immune cell population with pluripotency and…
Potent HPIV3-neutralizing IGHV5-51 Antibodies Identified from Multiple Individuals Show L Chain and CDRH3 Promiscuity - Human parainfluenza virus 3 (HPIV3) is a widespread pathogen causing severe and lethal respiratory illness in at-risk populations. Effective countermeasures are in various stages of development; however, licensed therapeutic and prophylactic options are not available. The fusion glycoprotein (HPIV3 F), responsible for facilitating viral entry into host cells, is a major target of neutralizing Abs that inhibit infection. Although several neutralizing Abs against a small number of HPIV3 F epitopes…
2-Bromopalmitate depletes lipid droplets to inhibit viral replication - The global impact of emerging viral infections emphasizes the urgent need for effective broad-spectrum antivirals. The cellular organelle, lipid droplet (LD), is utilized by many types of viruses for replication, but its reduction does not affect cell survival. Therefore, LD is a potential target for developing broad-spectrum antivirals. In this study, we found that 2-bromopalmitate (2 BP), a previously defined palmitoylation inhibitor, depletes LD across all studied cell lines and exerts…
The Crime Rings Stealing Everything from Purses to Power Tools - In Los Angeles, a task force of detectives is battling organized retail theft, in which boosted goods often end up for sale online—or commingled on store shelves with legitimate items. - link
How Quinta Brunson Hacked the Sitcom with “Abbott Elementary” - With “Abbott Elementary,” the comedian and writer found fresh humor and mass appeal in a world she knew well. - link
How Julien’s Auctions Leads the Booming Market in Celebrity Memorabilia - As the art market cools, Julien’s Auctions earns millions selling celebrity ephemera—and used its connections to help Kim Kardashian borrow Marilyn Monroe’s J.F.K.-birthday dress. - link
Has Putin’s Invasion of Ukraine Improved His Standing in Russia? - As Russians go to the polls, the economy is booming and the public feels hopeful about the future. But the politics of Putinism still depend on the absence of any means to challenge it. - link
Mike Johnson, the First Proudly Trumpian Speaker - Though he has adopted a “nerd constitutional-law guy” persona, he is in lockstep with the law-flouting former President. - link
+Sports betting is about the odds, but sports books decide whether the odds are fair. +
++The 2024 NCAA men’s and women’s basketball tournaments are here. +
++That means it’s time to fill out a bracket, to suddenly become the biggest fan of a school you’d never heard of before this week, or to coat your body in team colors before every game (depending on your obsession level, of course). +
++For many Americans, it’s also time to place some bets. +
++This is “the most mainstream betting event of the year,” says David Forman, vice president of research at the American Gaming Association (AGA). “It used to be office pools and squares contests.” Now, with the explosion in legalized gambling across the US, he says, “people in almost 40 states have the ability to bet on the tournament legally, and we think they’re going to bet about $2.7 billion on the men’s and women’s tournaments.” +
++If that estimate has you staggering, you obviously don’t watch all that much live sports. Because if you did, you would have already heard from a slew of celebrities, like Jamie Foxx and Rob Gronkowski, selling you on the virtues of major sports books like BetMGM, FanDuel, and DraftKings. You also must’ve missed the headlines around the Super Bowl last month, when the AGA estimated that 67.8 million Americans would bet roughly $23.1 billion. +
++Sports betting is bigger than ever, and 2023 was the biggest year yet. But as more states legalize gambling, effective regulation hasn’t always kept pace. And it’s left some bettors wondering whether their bet will be honored. +
++One of the reasons March Madness is such a big-time event for sports betting is the number of games being played — sometimes at the same time. In just the first four days of the tournament, there will be 48 games. +
++“The thing that makes it very bettable is the structure of the tournament,” says Jack Andrews, co-founder of Unabated Sports, a subscription service that purports to help sports bettors increase their chances of winning. “On the East Coast, the tournament starts at noon on Thursday [March 21]. And then you have game after game after game after game after game. It’s basically a betting bonanza for sports bettors from noon to midnight.” +
+ ++In-game betting and prop bets are other forms of wagering that are very popular during the tournament, “especially betting the over/unders,” says David Vinturella, an instructor at the University of Nevada Las Vegas who developed and taught the school’s first ever semester-long course in sports betting this year and who previously worked for a major sports book. +
++He explains over/under bets like this: Betting the over is wagering that a team will score more than sports books’ predicted figure. Betting the under is the opposite. +
++Another well-liked prop bet Andrews describes is betting on the first team to score 15 points. “That is hugely popular in Vegas,” he says. “That’s not really betting on the game, you know — instead you’re just betting on which team gets off to a hot start.” +
++With millions of people expected to place bets with sports books throughout the tournament, can bettors be sure they’ll be paid out if their long-shot bet wins big? +
++The answer to that question was a bit murky in the days before legal sports betting, when offshore sports books were the only game in town, says Andrews. “That’s the difference between the US and offshore sports books. If you have a problem offshore, the offshore sports book says, ‘I’m judge, jury, and executioner, and you’re out.’ Whereas in the states with regulated sports betting, [regulators] are supposed to make sure it’s a fair bet.” +
++Still, there have been stories recently about sports books in the US voiding bets that would’ve paid out big to bettors. The sports books use a clause in the fine print of their regulations saying that if there’s an obvious error with the odds in the bet (a.k.a. “palpable error”), they can cancel your bet. +
++Critics say this is unfair because the sports books have multiple chances to prevent a soon-to-be-voided bet from ever happening. “The bet is offered by the sports book, the bettor offers a wager to the sports book, and then the sports book accepts the wager,” says Andrews. “They had three chances to stop the bet from ever happening.” +
++Vinturella says that voided bets definitely happen, but that they are rare. “The process of getting a license and securing the license for a mobile sports betting company is not easy or cheap. So sports books don’t want to do anything that would jeopardize that license.” +
++Andrews agrees that most bettors will never have an issue with a sports book over a palpable error. “Ninety-nine percent of the time, sports books just eat the loss,” he says. But Andrews thinks regulators often have a “pro-operator” approach because “they’re funded by the operators,” and “they don’t want DraftKings to lose $1 billion because of something that should have never been out there.” +
++That’s why regulators should have clear sets of rules for determining what is and isn’t a clear mistake. +
++A good example is New Jersey, where the Division of Gaming Enforcement has a two-step process for deciding whether the error was palpable. Step one: Was the bet legal to begin with? If so, good. If not, the bet doesn’t count. Step two: Was there a risk of losing? If so, the wager stands. If there’s no risk, then the bet is voided because it must’ve been a mistake. +
++It’s that sort of easy-to-follow process that will let bettors trust regulators and confidently participate in the fast-growing billion-dollar industry — ultimately benefiting the sports books, too. +
++This story appeared originally in Today, Explained, Vox’s flagship daily newsletter. Sign up here for future editions. +
+What is the universe made out of? How should we define death? Where did dogs come from? And more! +
++Three years ago, Vox launched Unexplainable, a podcast about unanswered questions and what we learn when we explore the unknown. There’s a line I think about all the time from our very first episode. +
++“Whatever we know is provisional,” Priya Natarajan, a Yale physicist, told us about research on dark matter. But the sentiment also applies to science overall. “It is apt to change. What motivates people like me to continue doing science is the fact that it keeps opening up more and more questions. Nothing is ultimately resolved.” +
++Unexplainable isn’t about how scientists don’t know anything. Science is a process of narrowing a gap between the questions we have and the capabilities of our tools and know-how to answer them. In many cases, that gap appears closed. No one doubts, for instance, the existence of gravity. +
++But even then, it is a scientist’s job to have intellectual humility, or at least to be open to the idea that there’s still a piece missing — as there is with gravity — knowing the results could just end up confirming what they thought in the first place. +
++Really, science is about a big question: How do we know when we’ve completely learned something? +
++What this series has taught us is that answering the question is a journey. Sometimes the stories on that journey are exciting — like what happens when NASA launches a staggeringly powerful observatory into space. Sometimes they are frustrating, especially when answers to a question are held back by powerful forces like scientific funding, perverse incentives, or stigma. +
++Most often, though, the stories are deeply human: We ask questions because we’re trying to understand our imperfect bodies, our beautiful but fragile world, and our place in the universe just a bit better. +
++We’re drawn to questions because they are optimistic. They invite us to dream of a better world in which they are answered, where the gaps between questions and our capabilities to answer them are smaller. Scientific knowledge is a gift we can give the future. It’s worth getting right. +
++Here are some of the questions that astounded us the most. +
++If you go outside on a dark night, in the darkest places on Earth, you can see as many as 9,000 stars. They present as tiny points of light, but in reality, they are massive infernos. And while these stars seem astonishingly numerous to our eyes, they represent just the tiniest fraction of all the stars in our galaxy, let alone the universe. +
++All the stars in all the galaxies in all the universe barely even begin to account for all the stuff out there. Most of the matter in the universe is unseeable, untouchable, and, to this day, undiscovered. +
++Scientists call this unexplained stuff “dark matter,” and they believe there’s five times more of it in the universe than normal matter — the stuff that makes up you and me, stars, planets, black holes, and everything we can see in the night sky or touch here on Earth. It’s strange even calling all that “normal” matter because, in the grand scheme of the cosmos, normal matter is the rare stuff. But to this day, no one knows what dark matter is. +
++So, how might scientists actually “discover” it? +
++Further reading: Dark matter holds our universe together. No one knows what it is. +
++For decades, scientists have been trying to re-create in labs the conditions of early Earth. The thinking is, perhaps if they can mimic those conditions, they will eventually be able to create something similar to the first simple cells that formed here billions of years ago. From there, they could piece together a story about how life started on Earth. +
++This line of research has demonstrated some stunning successes. In the 1950s, scientists Harold Urey and Stanley Miller showed that it’s possible to synthesize the amino acid glycine — i.e., one of life’s most basic building blocks — by mixing gases believed to have filled the atmosphere billions of years ago and adding heat and simulated lightning. +
++Since then, scientists have been able to make lipid blobs that look a lot like cell membranes. They’ve gotten RNA molecules to form, which are like simplified DNA. But getting all these components of life to form in a lab and assemble into a simple cell — that hasn’t happened. +
++So what’s standing in the way? What would it mean if scientists succeeded in creating life in a bottle? They could uncover not just the story of the origin of life on Earth, but come to a shocking conclusion about how common life must be in the universe. +
++Further reading: 3 unexplainable mysteries of life on Earth +
++Wolves and dogs are nearly genetically identical, sharing 99.9 percent of their DNA (and are more similar to each other than we are to our close animal relatives, like chimps), yet they behave differently. Wolves “still have all of their natural hunting behaviors which dogs don’t have,” Kathryn Lord, a scientist who studies the evolution of behavior, says. “In the wolves, everything you greatly fear seeing in a dog pup is totally normal.” +
++Scientists still don’t know what precisely caused wolves and dogs to diverge from one another some 20,000 years ago. There are two main hypotheses. Either we humans domesticated wolves through a painstaking and dangerous process (possibly involving breastfeeding wolf pups!), or the wolves, essentially, domesticated themselves by venturing closer and closer to our trash (i.e., food). +
++The answer is more than just trivia. “A better understanding of how this might have happened long ago might give us a better understanding also to how animals and plants and such today might be able to — or not able to — adapt to us,” Lord says. +
++And to find out, Lord has been playing with some puppies: +
++Further reading: How gray wolves divided America +
++In 2018, a mother orca carried the carcass of her dead calf for 17 days, covering thousands of miles of ocean. The journey inspired many media reports, but also, one big question: Was this mother orca grieving? +
++Similar stories have popped up across the animal kingdom: of a dog refusing to leave its deceased owner’s grave, of elephants apparently convening in “mourning,” of geese that appear to grieve the loss of a mate and refuse to eat. +
++Though it’s easy to look at these behaviors and assume these animals experience a human-like version of grief, the science of studying animal emotion and death behaviors is much trickier. Some scientists suggest it’s not possible to know the interior life of an animal. Others say there’s a lot to be learned about the evolutionary history of grief if we go with the assumption that this is grief. +
++“There’s a principle in science of parsimony that was to say if something evolved in one species, it’s very unlikely that, you know, it didn’t also evolve in other species,” says Jessica Pierce, a bioethicist. +
++On Unexplainable, Pierce and two other researchers help us think through this thorny question: What can we learn from animal reactions to death? +
++Further reading: Breakups really suck, even if you’re a fish +
++It’s impossible to completely predict how evolution will play out in the future, but that doesn’t mean we can’t try. Reporter Mandy Nguyen asked biologists and other experts to weigh in: What would animals look like a million years from now? +
++The experts took the question seriously. “I do think it’s a really useful and important exercise,” Liz Alter, professor of evolutionary biology at California State University Monterey Bay told Nguyen. In thinking about the forces that will shape the future of life on Earth, we need to think about how humans are changing environments right now. +
++Further reading: The animals that may exist in a million years, imagined by biologists +
++Scientists grapple with the same relationship questions matchmakers, romance authors, poets, and anyone who has ever been single do. +
++“The big mystery is — do you really know who you want?” says Dan Conroy-Beam, a University of California Santa Barbara psychologist who studies relationship formation. Single people often have an imagined perfect partner, but is this person really the one who will make them happy? +
++The question seems simple, but it’s not trivial. A lot of time, energy, and heartache goes into finding solid relationships. “In a lot of senses, who you choose as a partner is the most important decision you’ll ever make,” Conroy-Beam says. “That’s going to affect your happiness, your health, and your overall well-being.” +
++Scientists don’t have all the answers, and they often disagree on which answers are even possible. But I found that their hypotheses — along with some advice from matchmakers and relationship coaches — can help us think through how love starts and how to maintain it once it’s found. +
++Further reading: What science still can’t explain about love +
++Before the moon landings, scientists thought they knew how the moon came to be, assuming it formed a lot like other planets did: Debris and dust leftover from the formation of the sun essentially clumped together to form rocky worlds like Earth and the moon. +
++But then, Apollo astronauts brought samples back from the lunar surface, and those rocks told a totally different story. +
++“Geologists had found that the moon was covered in a special kind of rock called anorthosite,” Unexplainable producer Meradith Hoddinott explains on the show. “Glittery, bright, and reflective, this is the rock that makes the moon shine white in the night sky. And at the time, it was thought, this rock can only be formed in a very specific way: magma.” +
++The indication there was magma means the moon must have formed in some sort of epic cataclysm: “Something that poured so much energy into the moon that it literally melted,” Hoddinott says. Scientists aren’t precisely sure how it all played out, but each scenario is a cinematic story of fiery apocalyptic proportions. +
++Further reading: How Apollo moon rocks reveal the epic history of the cosmo +
++Sound enters our ears, light enters our eyes, chemicals splash up in our nose and mouth, and mechanical forces graze our skin. It’s up to our brains to make sense of what it all means and create a seamless conscious experience of the world. +
++In the 1970s, psychologist Diana Deutsch discovered an audio illusion that made her feel like her brain was a little bit broken. “It seemed to me that I’d entered another universe or I’d gone crazy or something … the world had just turned upside down!” Deutsch recalls on Unexplainable. +
++Like the visual illusions that trick our eyes into seeing impossible things, the audio illusion Deutsch discovered in the 1970s fooled her ears. Sometimes illusions make us feel like, as Deutsch says, something is off with our minds. But really, these misperceptions show how our brains work. +
++Illusions teach us that our reality isn’t a direct real-time feed coming from our ears, eyes, skin, and the rest of our bodies. Instead, what we experience is our brain’s best guess. +
++But how do our brains do this? And how can scientists use that information to help people, invent new tools, or understand ourselves better? +
++Further reading: What science still doesn’t know about the five senses +
++In people with endometriosis, a disease in which tissue similar to what grows inside the uterus grows elsewhere in the body. It’s a chronic condition that can be debilitatingly painful. Yet doctors don’t fully understand what causes it, and treatment options are limited. +
++Worse, many people with endometriosis find that doctors can be dismissive of their concerns. It can take years to get an accurate diagnosis, and research into the condition has been poorly funded. +
++Vox reporter Byrd Pinkerton highlighted how frustrating it can be to suffer from an often-ignored, chronic condition. “It’s just so, so, so soul-crushing to just live in this body day in and day out,” one patient told Pinkerton. +
++Further reading: Menstrual fluid’s underexplored medical treasures +
++During the Apollo moon missions, astronauts went to the moon and, to save weight for returning to Earth, they dumped their waste behind. Across all the Apollo missions, astronauts left 96 bags of human waste on the moon, and they pose a fascinating astrobiological question. +
++Human waste — and in particular, feces — is teeming with microbial life. With the Apollo moon landings, we took microbial life on Earth to the most extreme environment it has ever been in. Which means the waste on the moon represents a natural, though unintended, experiment. +
++The question the experiment could answer: How resilient is life in the face of the brutal environment of the moon? And for that matter, if microbes can survive on the moon, can they survive interplanetary or interstellar travel? If they can survive, then maybe it’s possible that life can spread from planet to planet, riding on the backs of asteroids or other such space debris. +
++Further reading: Apollo astronauts left their poop on the moon. We gotta go back for that shit. +
++Many scientists have long wondered: Is there intelligent life out in the deep reaches of space? Climate scientist Gavin Schmidt and astrophysicist Adam Frank have a different question: Was there intelligent life in the deep reaches of Earth’s history? Could we find evidence of an advanced non-human civilization that lived perhaps hundreds of millions of years ago, buried in the Earth’s crust? +
++This is not strictly a “solar system” mystery, but it is cosmic in scope. At the heart of it, Schmidt and Frank are asking: How likely is an intelligent life form on any planet — here or in the deepest reaches of space — to leave a mark, a sign that they existed? And for that matter: Hundreds of millions of years from now, will some alien explorers landing on Earth be able to find traces of humans if we’re long, long gone? +
++Further reading: The Silurian hypothesis: Would it be possible to detect an industrial civilization in the geological record? +
++We know life when we see it. Flying birds are clearly alive, as are microscopic creatures like tardigrades that scurry around in a single drop of water. +
++But do we, humans, know what life fundamentally is? No. +
++“No one has been able to define life, and some people will tell you it’s not possible to,” says New York Times columnist and science reporter Carl Zimmer. It’s not for a lack of trying. “There are hundreds, hundreds of definitions of life that scientists themselves have published in the scientific literature,” he says. +
++The problem is, for every definition of life, there’s a creature or perplexing life-like entity that just sends us right back to the drawing board. +
++Further reading: What is life? Scientists still can’t agree. +
++Death used to be fairly self-evident. Someone stopped breathing, their heart stopped beating — they were dead. But new technologies have forced us to ask: When is someone actually dead? +
++Now, new research is raising a further question: Might it even be possible, in some instances or for just a brief moment, to reverse death? It sounds outlandish, but researchers at Yale University describe how they were able to partially revive disembodied pigs’ brains several hours after the pigs’ death. +
++If this technology progresses, could it redefine death? +
++Further reading: There’s a surprisingly rich debate about how to define death +
++What would it be like to be near a dinosaur? From fossil evidence, scientists can get a decent sense of what these ancient creatures looked like. But they still don’t know what they would have sounded like. Whereas hard tissues like bone can fossilize and leave us information about dinosaur stature and shape millions of years later, soft tissues — like the muscle and cartilage that help generate sound — do not fossilize as readily. +
++Many Hollywood depictions of dinosaur roars are not based in scientific reality (the T-Rex roar in Jurassic Park is partially based on an elephant. A mammal! Dinosaurs were reptiles!). So where do scientists start in trying to imagine realistic dinosaur noises? They look to dinosaurs’ closest relatives alive on Earth today. +
++Further reading: What did dinosaurs actually sound like? Take a listen. +
++Today’s internet is built on a series of locks and keys that protect your private information as it travels through cyberspace. “Encryption is basically like this cloak that wraps your private information,” Unexplainable’s Meradith Hoddinott says on the show. If someone intercepts your message as it travels around the web, “it just looks like random static” +
++But there’s a fear: With increases in computing power, it’s possible that one day all these locks can be broken. +
++So cryptographers are trying to probe deep, complicated mathematical theory. They want to know: Could a perfect, unbreakable “lock” even exist? +
++Further reading: Inside the quest for unbreakable encryption at MIT Tech Review +
++There is really good research out there that shows that if a parent drinks too much alcohol during pregnancy, it can have clear consequences for the child, affecting everything from their weight and size to their cognitive abilities, vision, and hearing. There is also good evidence that smoking cigarettes can harm a fetus. +
++As Vox reporter Keren Landman found in recent reporting, by contrast, the consequences of cannabis use are less obvious. The studies that have been done have had mixed results. Researchers aren’t entirely clear on whether cannabis use affects birth weights, and while there are some connections drawn between cannabis use in pregnancy and attention, hyperactivity, and aggression in kids, these results are also not clear-cut. +
++In spite of these mixed results, Landman found that cannabis use in pregnancy is still heavily penalized in states across the US — even in states where the drug is legal. Pregnant parents sometimes use cannabis to help them cope with morning sickness or other pregnancy symptoms, but in many states, they can have their children taken away by child protective services, or even be arrested and jailed. +
++Why is there such a mismatch between the science and the policy? And how can we improve both, and make parents feel safe discussing cannabis use with their providers? +
++Further reading: Is weed safe in pregnancy? +
++In the early 1900s, Henrietta Leavitt, a Massachusetts-born “computer” who worked at the Harvard College Observatory, published a discovery that may sound small but is one of the most important in the history of astronomy: She found a way to measure the distance to certain stars. +
++Over time, scientists kept building on Leavitt’s ruler to measure the universe. As they used these measuring tools, their understanding of the universe evolved. They realized it was far bigger than previously thought, there are billions of galaxies, and it’s expanding: Those galaxies are moving farther and farther away from one another. +
++Astronomers also realized that the universe had a beginning. If galaxies are moving away from one another now, it means they were closer together in the past — which led scientists to the idea of the Big Bang. +
++It also led them to realize that the universe may, eventually, end. +
++Further reading: How scientists discovered the universe is really freaking huge +
++Reality stars are suing Bravo (and each other) while wrestling with their own reality. +
++Suits may be having a moment, but when it comes to compelling legal drama, Bravo has had the TV genre on lock. The past few years have been rife with court cases: Jen Shah’s fraud case and subsequent prison sentencing made Real Housewives of Salt Lake City appointment TV, while Erika Jayne’s ex-husband’s embezzlement case — the disbarred attorney stands accused of stealing from the relatives of airplane crash victims — gave Real Housewives of Beverly Hills one of its buzziest storylines in years. +
++However, the same court drama viewers have become accustomed to watching on Bravo is currently affecting the network off-screen, as several ex-Bravolebrities are laying out behind-the-scenes grievances with producers through legal means. +
++A sexual harassment lawsuit against Bravo filed by former Real Housewives of New Jersey star Caroline Manzo appears to be stalling a season of the Peacock spinoff Real Housewives Ultimate Girls Trip. Meanwhile, former RHOBH star Brandi Glanville, Manzo’s alleged assailant, is threatening to sue Bravo for its treatment of her following the controversy. Additionally, ex-Real Housewives of New York cast member Leah McSweeney is suing Bravo and Real Housewives executive producer Andy Cohen for discrimination and retaliation. (She’s also accused Cohen of doing cocaine with Real Housewives, which could become a war of its own.) Shortly after McSweeney’s filing, Cohen’s attorney, Orin Snyder, responded with a letter, claiming her complaint was “littered with false, offensive, and defamatory statements.” +
++There’s also former Vanderpump Rules star Rachel Leviss, who’s surprisingly not attempting to sue Bravo post-Scandoval. Rather, she’s brought a lawsuit alleging eavesdropping and revenge porn against her co-stars Tom Sandoval and Ariana Madix, regarding an explicit FaceTime call Sandoval recorded, which exposed the affair. +
++This isn’t the first time Bravo has been legally confronted over the way shows are made. In 2022, Real Housewives of Atlanta OG NeNe Leakes sued Bravo for racial discrimination (she later dropped it). And last year, former RHONY star Bethenny Frankel made somewhat inconsistent and confusing efforts toward a “reality reckoning,” which mostly manifested in a podcast series. However, her outspokenness about pay disparity, unsafe working conditions, and the general power dynamic between reality stars and producers has clearly had a ripple effect in the Bravo community. +
++But as the Real Housewives universe continues to expand and grow in popularity, stars of these programs are finally wondering who’s responsible for their own reality. +
++During last year’s SAG-AFTRA and WGA strikes, Frankel announced her efforts toward a reality-TV union in a Variety interview. In August, defense lawyers Mark Geragos and Bryan Freedman, reportedly representing Frankel and other reality stars, sent NBCUniversal (which owns Bravo and Peacock) a formal request to preserve documents potentially relevant to a lawsuit. In it, they accused the media company of “grotesque and depraved mistreatment” and covering up “acts of sexual violence.” (An NBCUniversal spokesperson responded that the company is “committed to maintaining a safe and respectful workplace” and takes “timely, appropriate action” toward complaints.) Since then, Frankel’s claimed she’s “not hiring lawyers” nor suing Bravo but helping other aggrieved reality stars seek justice. While not the first to confront reality producers over working conditions, she seems to have provided fellow Bravolebs a framework for addressing the power dynamics in their workplaces. +
++On January 26, Deadline reported that Manzo was suing Bravo and its affiliated companies — NBCUniversal, Shed Media, Forest Productions, Warner Bros. Entertainment, and Peacock TV — for “encouraging” and “allowing” Glanville to sexually harass her during the filming of the Morocco-set season of Real Housewives Ultimate Girls Trip. In the complaint, Manzo’s attorneys detail that Glanville allegedly “[held] MANZO down with her body” and “thrust her tongue in MANZO’s mouth” during a party. When Manzo got up to go to the bathroom, she claims that Glanville followed her and continued to assault her. +
++Strikingly, Manzo is not suing Glanville for sexual harassment or assault. Instead, her lawsuit seeks to hold Bravo responsible for hiring Glanville despite her “prior deviant sexual proclivities and sexually harassing conduct” as well as “ply[ing] GLANVILLE with copious amounts of alcohol so that she would act outrageous.” She’s seeking unspecified damages. +
+ ++Alcohol is also relevant in McSweeney’s complaint, which is already proving to be a larger point of contention among fans. Before she filed court documents, the streetwear founder had spoken publicly about producers’ alleged disregard for her and other cast members’ sobriety on RHONY and season three of RHUGT in a Vanity Fair exposé. +
++In her lawsuit, McSweeney accuses Bravo and its third-party producers of “engaging in guerrilla-type psychological warfare intended to pressurize [her] into a psychological break and cause [her] to relapse.” Most of her accusations focus on producers’ alleged failure to accommodate her “bipolar, depression, and anxiety disorders,” in addition to her alcohol addiction. In her complaint, she references an incident where she was allegedly prohibited from leaving filming to visit her dying grandmother or else be terminated. +
++Critical commenters on social media have argued that it is McSweeney’s personal responsibility to maintain her own sobriety. But Dan Braverman, an employment law attorney at Romano Law, says her addiction to alcohol can be deemed “a disability under federal, state, and local discrimination laws.” +
++“This would necessitate that McSweeney be provided reasonable accommodations and not be discriminated against or fired for that reason,” he told Vox. While Braverman notes that McSweeney’s status as a contract worker would typically complicate this situation, in New York, where McSweeney has filed her complaint, the City Human Rights Law says that all independent contractors “have the right to receive reasonable accommodations for needs related to disabilities.” +
++Still, some viewers say that McSweeney’s claims are undermined by her past behavior on the franchise. In her first season of RHONY, she says she started drinking again six months prior to filming. A clip of McSweeney encouraging her RHUGT cast members to drink because they were boring her has since resurfaced. Naysayers also point out that she chose to return to Bravo following her negative experiences on RHONY. While this doesn’t automatically disprove her claims — people return to unpleasant job situations out of necessity — it could be used against her in court, according to Braverman. +
++“If McSweeney voluntarily chose to enter this environment again by rejoining the show and encouraging the behavior she is now alleging was discriminatory, the defense could argue that she contributed to some or all of her damages,” he said. +
++Still, the overwhelmingly critical response to McSweeney’s claims reflects a moral quandary that’s always undermined the pleasure of viewing reality TV — especially in the Bravo universe. +
++That dilemma has become more pronounced as high-stakes, “earth-shattering” drama has increasingly become the norm and desired outcome on Bravo. But after an explosive cheating scandal that incites cyberbullying or a storyline that culminates in a DUI, who’s responsible for the devastation that’s left behind? +
++As demonstrated by Manzo, McSweeney, Leakes, and Frankel, that question of accountability is partially a legal matter regarding what reality performers are owed. As Braverman noted, most reality stars are independent contractors — not employees, who are more thoroughly protected under federal laws. Nevertheless, legality doesn’t always overlap with morality. Nor do the current state of employment laws negate the ethical problem of reality performers being overworked, underpaid, mistreated, or placed in harmful work environments. +
++Still, the point at which producers are expected to intervene when, say, a Real Housewife has too much to drink remains murky. At the very least, it should probably happen when someone, as Manzo’s alleging, is committing a crime against another person. But what about when someone is destroying their own life? How does production proceed when, unlike McSweeney, a reality star isn’t even aware that they could potentially be an addict and can also continue their alcohol consumption off-camera? +
++The issue has presented itself with Real Housewives of Orange County cast member Shannon Beador, who received a DUI last year following a hit-and-run and was sentenced to three years of probation. For several seasons now, including the latest season 17, Beador’s drunken behavior has been a point of concern amongst her castmates, and she’s repeatedly denied having a problem. +
++This type of personal wreckage makes for “good” TV, which is ultimately good for Bravo. Likewise, producers and editors have seemingly played into Beador’s drinking storyline, drawing comedy from her habit of making inebriated phone calls to her fellow Housewives and forgetting them the next day. Shortly after her DUI arrest, she was also permitted to attend Bravo’s annual convention, BravoCon — her presence being somewhat of a draw for the event. There, she announced that she completed “28 days of behavioral wellness” with an alcohol specialist. +
++Beador has been a thoroughly compelling and enjoyable person to watch outside her troubling drinking habits. However, her story arc represents the risk and subsequent discomfort of capturing someone’s life over a long period of time, which can often illuminate a pattern of dangerous habits and poor decision-making. It’s different from watching a competition show like The Bachelor and Love Island where cast members are placed in a temporary, more controlled setting. On more loosely structured, slice-of-life shows like Real Housewives or Vanderpump Rules, there is an understanding that the cast is partially narrativizing their own lives. +
++It’s common knowledge that these plots are produced and edited to varying degrees. But in the case of having a seven-month-long affair with your close friend’s life partner, for example, those facts can’t really be manipulated. This reality makes Leviss’s lawsuit post-Scandoval a little harder to swallow. +
+ ++Following the scandal, Leviss decided to forgo filming the subsequent season 11. Instead, she launched a podcast called Rachel Goes Rogue, detailing her side of the controversy. She also appeared on Just B with Bethenny Frankel, where she discussed the machinations behind her so-called “villain edit.” +
++Without downplaying the potential harm Madix and Sandoval may have caused in this dirty FaceTime debacle, it’s hard not to view her lawsuit as an attempt to regain control of a narrative where she inarguably cast herself as a villain. Plenty of Bravolebrities are already doing this by way of podcasts and tell-all interviews. But Leviss’s lawsuit represents a new method in which Bravolebs may be handling the dissatisfaction and humiliation they experience on their shows in the future and are already presently doing. +
++For now, it’s unclear whether Madix actually distributed the video, and if she did, whether it was with an intent to harm Leviss. What’s more firmly laid out in the complaint, though, is a power dynamic where Bravo and other Vanderpump Rules cast members benefited from her bad decisions. Overall, it seems like reality stars and fans are still reconciling whether this is an ethical issue or just the inherent bargain of doing reality TV. Maybe it’s both. +
++
++
IOA dissolves ad-hoc committee for wrestling, WFI to take charge - The IOA said that the decision was also guided the successful conduct of the selection trials for next month’s Olympic qualifying tournament for which the panel collaborated with WFI
‘Rohit will have his hand on my shoulders’: Hardik Pandya on taking up MI captaincy - Pandya admitted his move of leaving the Gujarat Titans’ captaincy and replacing Rohit at the helm in Mumbai Indians did upset a section of fans.
WPL Final | Lacked self-belief in pressure situations last year, this season it stayed intact: Smriti Mandhana - Former RCB skipper Virat Kohli, who is back in India for the IPL, congratulated Smriti Mandhana and the team following the eight-wicket triumph in the WPL final
Third ODI against Bangladesh | Sri Lanka wins toss, bats first - Sri Lanka levelled the series with a three-wicket victory in the second game following a six-wicket loss in the opener.
FA Cup | Man United edge out Liverpool in extra-time thriller to enter semifinals - Manchester United will play Coventry City in the semifinals while Manchester City and Chelsea face each other
NCP received its largest single-day donation of electoral bonds while in power - The party received Rs 10 crore on January 11, 2022, the most it had received on any single-day
UN agency says ‘famine is imminent’ in Gaza; aid distribution is virtually impossible because of Israeli restrictions - In its latest report, the World Food Programme has said that virtually everyone in Gaza is struggling to get enough food and around 2,10,000 people in northern Gaza are in Phase 5, the highest, which refers to catastrophic hunger
I will come out of Mysuru palace to listen to the people, says Yaduveer - If elected, I’ll discharge my duties as any other MP, engaging with the public and reaching out to them on different platforms besides remaining accessible to them any time of the year
Lok Sabha polls 2024 | NDA finalises seat-sharing agreement in Bihar - The announcement was made by BJP Bihar in-charge Vinod Tawde in New Delhi.
Watch | The strategies of the BJP and Congress | Lok Sabha elections 2024 - Three noteworthy and significant points on the general elections
Predicting Putin’s landslide was easy, but what comes next? - The Russian president will get a confidence boost from the tightly controlled election, says Steve Rosenberg.
West condemns Russian ‘pseudo-election’ as Putin claims landslide win - No credible opposition candidate was allowed to stand in the vote which could see Putin in power until 2030.
Putin names Navalny and claims he agreed swap - Russia’s leader always refused to the Kremlin critic by name, but now he is dead, that has changed.
Putin thanks Russia after predictable win - President Vladimir Putin thanks Russians for putting their trust in him as he celebrates his election win.
Trabzonspor fans attack Fenerbahce players after loss - Trabzonspor fans run on to the field and attack Fenerbahce players after Sunday’s Super Lig match.
Redwoods are growing almost as fast in the UK as their Californian cousins - New study finds that giant sequoias add 70 cm of height and store 160 kg of carbon per year. - link
2025 Maserati Grecale Folgore review: A stylish SUV, but a hard EV sell - It’s not really as good as the internal combustion version, sadly. - link
Tick-killing pill shows promising results in human trial - Should it pan out, the pill would be a new weapon against Lyme disease. - link
ASCII art elicits harmful responses from 5 major AI chatbots - LLMs are trained to block harmful responses. Old-school images can override those rules. - link
Finally, engineers have a clue that could help them save Voyager 1 - A new signal from humanity’s most distant spacecraft could be the key to restoring it. - link
The doc told him that masturbating before sex often helped men last longer during the act. -
++The man decided, “What the hell, I’ll try it,” +
++He spent the rest of the day thinking about where to do it. He couldn’t do it in his office. He thought about the restroom, but that was too open. He considered an alley, but figured that was too unsafe. +
++Finally, he realized his solution. On his way home, he pulled his truck over on the side of the highway. He got out and crawled underneath as if he was examining the truck. Satisfied with the privacy, he undid his pants and started to masturbate. +
++He closed his eyes and thought of his lover. As he grew closer to orgasm, he felt a quick tug at the bottom of his pants. Not wanting to lose his mental fantasy or the orgasm, he kept his eyes shut and replied, “What?” +
++He heard, “This is the police. What’s going on down there?” The man replied, “I’m checking out the rear axle, it’s busted.” +
++“Well,” the cop answered, “you might as well check your brakes too while you’re down there because your truck rolled down the hill 5 minutes ago.” +
+ submitted by /u/KongLongDong77
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Smart Wife -
+
+After being married for 50 years, I took a careful look at my wife one day and said….
“Fifty years ago we had a cheap house, a junk car, slept on a sofa bed, and watched a 10-inch black and white TV. But hey I got to sleep every night with a hot 23-year-old girl. Now… I have a $750,000 home, a $45,000 car, a nice big bed, and a large-screen TV, but I’m sleeping with a 73-year-old woman.
So I said to my wife:
“It seems to me that you’re not holding up your side of things.”
My wife is a very smart woman.
She told me to go out and find a hot 23-year-old girl and she would make sure that I would once again be living in a cheap house, driving a junk car, sleeping on a sofa bed, and watching a 10-inch black and white TV.
Aren’t older women great? They really know how to solve an old guy’s problems!
+
submitted by /u/Azurebluenomad
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Fidel Castro, Vladimir Putin, and the Oort Cloud are riding on a train -
++Fidel Castro, Vladimir Putin, and the Oort Cloud are riding on a train. Fidel Castro pulls an expensive cigar out of his pocket, lights it, and then throws it out the window after only a few puffs. Vladimir Putin and the Oort Cloud are both surprised by this and ask, “What are you doing, Fidel? That’s an expensive cigar!” To which Castro responds, “In your country or post-heliopausal region perhaps, but in my country these are as cheap as dirt.” +
++Then Vladimir Putin pulls a bottle of expensive Russian vodka out of his pocket and, after a few sips, throws the bottle out the window. Fidel Castro and the Oort Cloud are both surprised and ask, “What are you doing, Vladimir? That is expensive vodka!” To which Putin responds, “Pah! In your country or post-heliopausal region perhaps, but in Russia this vodka is as plentiful as rainwater.” +
++The Oort Cloud considers this for a minute or two, and then throws a six-mile-wide comet out of the window which, on impact, incinerates everything within a thirty-mile radius, causes massive earthquakes and tsunamis for thousands of miles in each direction, and kicks up a cloud of dust and ash that eventually encircles the Earth, wiping out nearly all forms of life in a matter of months. +
+ submitted by /u/RJamieLanga
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Good oral sex will make your day; good anal sex… -
++will make your hole weak +
+ submitted by /u/NYY15TM
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Little Jimmy ends up in the wardrobe with his mothers affair… -
++“It’s dark in here” says little Jimmy. +
++The guy manages not to scream in shock and after some time he makes a deal with Jimmy. For the price of a baseball, Jimmy won’t tell his dad about the guy in Mommys wardrobe when daddy came home +
++The man keeps his word, gifts Jimmy a new baseball at the next visit, just to end up in the wardrobe again. +
++“It’s dark in here…” says little Jimmy. +
++Again the guy manages to talk Jimmy out of his plan to tell his father. This time for the price of a new baseball glove. +
++Once more he keeps word. Thinks 3 times is the charm and nothing will happen, just to end up in the wardrobe again… +
++“It’s dark in here…” says little Jimmy… The man sighs and a shirt, signed by the local baseball legend changes the owner. +
++At a weekend, Jimmys father wants to throw a few balls with his boy and is astonished when Jimmy comes out to play with the shirt, new ball and glove. All things he never bought for his boy. After a stern talking, Jimmy finally tells his father he got all the stuff as a gift from a guy so he would lie about something. Livid about the sin his boy committed, the father takes Jimmy to the next church with a confessional and places him into the confession stand. +
++Finally alone, Jimmy mutters: “It’s dark in here…” And the priest goes: " Holy sh*t boy. Can you please just leave me alone?" +
+ submitted by /u/InitiativeExcellent
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