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<title>29 December, 2023</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Tying the Knot: Unraveling the Intricacies of the Coronavirus Frameshift Pseudoknot</strong> -
<div>
Understanding and targeting functional RNA structures towards treatment of coronavirus infection can help us to prepare for novel variants of SARS-CoV-2 (the virus causing COVID-19), and any other coronaviruses that could emerge via human-to-human transmission or potential zoonotic (inter-species) events. Leveraging the fact that all coronaviruses use a mechanism known as -1 programmed ribosomal frameshifting (-1 PRF) to replicate, we apply algorithms to predict the most energetically favourable secondary structures (each nucleotide involved in at most one pairing) that may be involved in regulating the -1 PRF event in coronaviruses, especially SARS-CoV-2. We compute previously unknown most stable structure predictions for the frameshift site of coronaviruses via hierarchical folding, a biologically motivated framework where initial non-crossing structure folds first, followed by subsequent, possibly crossing (pseudoknotted), structures. Using mutual information from 181 coronavirus sequences, in conjunction with the algorithm KnotAli, we compute secondary structure predictions for the frameshift site of different coronaviruses. We then utilize the Shapify algorithm to obtain most stable SARS-CoV-2 secondary structure predictions guided by frameshift sequence-specific and genome-wide experimental data. We build on our previous secondary structure investigation of the singular SARS-CoV-2 68 nt frameshift element sequence, by using Shapify to obtain predictions for 132 extended sequences and including covariation information. Previous investigations have not applied hierarchical folding to extended length SARS-CoV-2 frameshift sequences. By doing so, we simulate the effects of ribosome interaction with the frameshift site, providing insight to biological function. We contribute in-depth discussion to contextualize secondary structure dual-graph motifs for SARS-CoV-2, highlighting the energetic stability of the previously identified 3_8 motif alongside the known dominant 3_3 and 3_6 (native-type) -1 PRF structures. Integrating experimental data within minimum free energy (MFE) hierarchical folding algorithms provides novel structure predictions to distill the relationship between RNA structure and function. In particular, fully categorizing most stable secondary structure predictions via hierarchical folding supports our identification of motif transitions and critical site targets for future therapeutic research.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.28.573501v1" target="_blank">Tying the Knot: Unraveling the Intricacies of the Coronavirus Frameshift Pseudoknot</a>
</div></li>
<li><strong>CParty: Conditional partition function for density-2 RNA pseudoknots</strong> -
<div>
RNA molecules fold into biologically important functional structures. Efficient dynamic programming RNA (secondary) structure prediction algorithms restrict the search space to evade NP-hardness of general pseudoknot prediction. While such prediction algorithms can be extended to provide a stochastic view on RNA ensembles, they are either limited to pseudoknot-free structures or extremely complex. To overcome this dilemma, we provide the theoretical framework and implementation for our algorithm, CParty, that follows the hierarchical folding hypothesis, i.e., the bio-physically well-motivated assumption that non-crossing structures fold relatively fast prior to the formation of pseudoknot interactions. Thus, we efficiently compute the conditional partition function (CPF) given a non-crossing structure G for a subset of pseudoknotted structures, i.e., density-2 structures G U G’ for non-crossing disjoint structure G’. Notably, this can enable sampling from the hierarchical distribution P(G’|G). With CParty we develop for the first time an unambiguous scheme based on HFold, i.e., the minimum free energy hierarchical folding algorithm based on a realistic pseudoknot energy model. Thus, we develop the first partition function variant for density-2 structures. Compared to the only other available pseudoknot partition function algorithm, which covers simple pseudoknots (and follows a different strategy, mapped from a pure minimum free energy structure prediction), our method covers a much larger structure class; at the same time, it is significantly more efficient—reducing the time as well as the space complexity by a quadratic factor. Summarizing, we provide an efficient, cubic time, algorithm for the stochastic analysis of pseudoknotted RNAs, which enables novel applications. We discuss one such application, i.e., how the CPF for a pseudoknotted therapeutic target in SARS-CoV-2 can provide insight into RNA structure formation.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.05.16.541023v2" target="_blank">CParty: Conditional partition function for density-2 RNA pseudoknots</a>
</div></li>
<li><strong>The 8C model of vaccination readiness: A common framework to facilitate cross-study comparisons.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Several factors can potentially influence an individual’s vaccination readiness. To facilitate cross-study comparisons, it is essential that researchers use a shared framework to measure these factors. This would not only help determine their relative importance cross different contexts but also would aid in tailoring interventions to enhance vaccine uptake. Historically, five psychological antecedents of vaccination were identified: confidence, complacency, constraints, calculation, and collective responsibility. This 5C scale was later expanded to a 7C model by incorporating two additional components: compliance and conspiracy. Building upon this framework, we propose an eighth component, certification, defined as the person’s self-report that, in the past, they have had to provide evidence of vaccination. This component addresses a significant gap in the 7C model, as some individuals reported taking the COVID-19 vaccine primarily to obtain proof of vaccination, a motivation not captured by the 7C model. Our confirmatory factor analysis (N = 406) of a bifactor model of US citizens9 self-reported COVID-19 vaccination status showed that this eighth component had good psychometric properties and the 8C model had slightly higher criterion validity than the 7C model. We present the 8C model as a framework that provides a richer and more complete descriptions of the factors that determine vaccination readiness and encourage future studies of vaccination readiness to utilise it.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.22.23300464v1" target="_blank">The 8C model of vaccination readiness: A common framework to facilitate cross-study comparisons.</a>
</div></li>
<li><strong>BNT162b2 XBB1.5-adapted Vaccine and COVID-19 Hospital Admissions and Ambulatory Visits in US Adults</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Importance Data describing the early additional protection afforded by recently recommended XBB1.5-adapted COVID-19 vaccines are limited. Objective We estimated the association between receipt of BNT162b2 XBB1.5-adapted vaccine (Pfizer-BioNTech 2023-2024 formulation) and medically attended COVID-19 outcomes among adults &gt;=18 years of age. Design, Setting, and Participants We performed a test-negative case-control study to compare the odds of BNT162b2 XBB1.5-adapted vaccine receipt between COVID-19 cases and test-negative controls among adults in the Kaiser Permanente Southern California health system between October 11 and December 10, 2023. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated from multivariable logistic regression models that were adjusted for patient demographic and clinical characteristics. Exposure The primary exposure was receipt of BNT162b2 XBB1.5-adapted vaccine compared to not receiving an XBB1.5-adapted vaccine of any kind, regardless of prior COVID-19 vaccination or SARS-CoV-2 infection history. We also compared receipt of prior (non-XBB1.5-adapted) versions of COVID-19 vaccines to the unvaccinated to estimate remaining protection from older vaccines. Main Outcomes and Measures Cases were those with a positive SARS-CoV-2 polymerase chain reaction test, and controls tested negative. Analyses were done separately for COVID-19 hospital admissions, emergency department (ED) and urgent care (UC) encounters, and outpatient visits. Results Among 4232 cases and 19,775 controls with median age of 54 years, adjusted ORs for testing positive for SARS-CoV-2 among those who received BNT162b2 XBB1.5-adapted vaccine a median of 30 days ago (vs not having received an XBB1.5-adapted vaccine of any kind) were 0.37 (95% CI: 0.20-0.67) for COVID-19 hospitalization, 0.42 (0.34-0.53) for ED/UC visits, and 0.42 (0.27-0.66) for outpatient visits. Compared to the unvaccinated, those who had received only older versions of COVID-19 vaccines did not show significantly reduced risk of COVID-19 outcomes, including hospital admission. Conclusions and Relevance Our findings reaffirm current recommendations for broad age-based use of annually updated COVID-19 vaccines given that (1) XBB1.5-adapted vaccines provided significant additional protection against a range of COVID-19 outcomes and (2) older versions of COVID-19 vaccines offered little, if any, additional protection, including against hospital admission, regardless of the number or type of prior doses received.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.24.23300512v1" target="_blank">BNT162b2 XBB1.5-adapted Vaccine and COVID-19 Hospital Admissions and Ambulatory Visits in US Adults</a>
</div></li>
<li><strong>Dengue Virus Serotype 2 Cosmopolitan C Genotype Reemerges with a New Subclade in Southwest Region of Bangladesh</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In 2023, the Dengue virus (DENV) outbreak infected over 0.3 million cases and 1500 deaths in Bangladesh. Although the the serotype and genotype data were unavailable. Our study conducted serotyping and genomic surveillance in four districts of Southwest Bangladesh between September and October 2023. The surveillance data from 2019 to 2023 extracted from the Directorate General of Health Services in Bangladesh indicated a significant increase of Dengue infections in 2023, particularly during September-November. The two-layered hypothesis examination confirmed that, despite endemic months, 2023 dengue outbreak had a higher morbidity rate compared to previous years (2019-2022) in Southwest of Bangladesh. Serotyping and E gene sequence analysis of 25 randomly selected positive samples reveals that DENV-2 was the sole serotype circulating in this region during the study period. Genomic analysis exposed a new subclade of DENV-2, classified under Cosmopolitan genotype within C clade, distinct from previous years Bangladeshi variants until 2022. This subclade, possibly migrating from India, might be emerged during COVID-19 pandemic years and exhibited higher morbidity rates, thus challenging our existing mitigation strategies. This investigation provides valuable insights for public health interventions and underscores the importance of continuous genomic surveillance in managing Dengue outbreaks. Key words: Dengue serotype 2, Bangladesh, New Subclade, Cosmopolitan C, Phylogenetic tree
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.24.23300504v1" target="_blank">Dengue Virus Serotype 2 Cosmopolitan C Genotype Reemerges with a New Subclade in Southwest Region of Bangladesh</a>
</div></li>
<li><strong>Learning the fitness dynamics of pathogens from phylogenies</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The dynamics of pathogen genetic diversity, including the emergence of lineages with increased fitness, is a foundational concept of disease ecology with key public health implications. However, the identification of distinct lineages and estimation of associated fitness remain challenging, and are rarely done outside densely sampled systems. Here, we present a scalable framework that summarizes changes in population composition in phylogenies, allowing for the automatic detection of lineages based on shared fitness and evolutionary relationships. We apply our approach to a broad set of viruses and bacteria (SARS-CoV-2, H3N2 influenza, Bordetella pertussis and Mycobacterium tuberculosis) and identify previously undiscovered lineages, as well as specific amino acid changes linked to fitness changes, the findings of which are robust to uneven and limited observation. This widely-applicable framework provides an avenue to monitor evolution in real-time to support public health action and explore fundamental drivers of pathogen fitness.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.23.23300456v1" target="_blank">Learning the fitness dynamics of pathogens from phylogenies</a>
</div></li>
<li><strong>Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study.</strong> -
<div>
COVID-19 remains a significant international public health concern. Yet, the mechanisms through which symptomatology emerges remain poorly understood. While SARS-CoV-2 infection may induce prolonged inflammation within the central nervous system, the evidence primarily stems from limited small-scale case investigations. To address this gap, our study capitalized on longitudinal UK Biobank neuroimaging data acquired prior to and following COVID-19 testing (N=416 including n=224 COVID-19 cases; Mage=58.6). Putative neuroinflammation was assessed in gray matter structures and white matter tracts using non-invasive Diffusion Basis Spectrum Imaging (DBSI), which estimates inflammation-related cellularity (DBSI-restricted fraction; DBSI-RF) and vasogenic edema (DBSI-hindered fraction; DBSI-HF).We hypothesized that COVID-19 case status would be associated with increases in DBSI markers after accounting for potential confound (age, sex, race, body mass index, smoking frequency, and data acquisition interval) and multiple testing. COVID-19 case status was not significantly associated with DBSI-RF (all |B|&lt;0.28, pFDR &gt;0.05), but with greater DBSI-HF in left pre- and post-central gyri and right middle frontal gyrus (all B&gt;0.3, all pFDR=0.03). Intriguingly, the brain areas exhibiting increased putative vasogenic edema had previously been linked to COVID-19-related functional and structural alterations, whereas brain regions displaying subtle differences in cellularity between COVID-19 cases and controls included regions within or functionally connected to the olfactory network, which has been implicated in COVID-19 psychopathology. Nevertheless, our study might not have captured acute and transitory neuroinflammatory effects linked to SARS-CoV-2 infection, possibly due to symptom resolution before the imaging scan. Future research is warranted to explore the potential time- and symptom-dependent neuroinflammatory relationship with COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.07.20.549891v3" target="_blank">Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study.</a>
</div></li>
<li><strong>The double bind of communicating about zoonotic origins: Describing exotic animal sources of COVID-19 increases both healthy and discriminatory avoidance behaviors</strong> -
<div>
Many novel diseases are of zoonotic origin, likely including COVID-19. Describing diseases as originating from diverse exotic animals can increase risk perceptions and protective avoidance behaviors, but may also activate stereotypes, increasing discriminatory behaviors and disease stigma. Data from the first several weeks of the US COVID-19 pandemic tested how communications about zoonotic disease origins affect people’s risk perceptions, health behaviors, and stigma. Participants (N = 677) who read news articles describing exotic animals (e.g., snakes) as sources of COVID-19 viewed the virus as riskier and reported stronger intentions to engage in preventative behaviors (e.g., handwashing), relative to those who read about a familiar source (pigs). Reading exotic origin descriptions was associated with stronger intentions to avoid Asian individuals and animal products, both of which contributed to greater stigma for COVID-19. Results have implications for public health communicators who aim to increase risk perceptions without activating stigma or prejudice.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/psyarxiv/948qn/" target="_blank">The double bind of communicating about zoonotic origins: Describing exotic animal sources of COVID-19 increases both healthy and discriminatory avoidance behaviors</a>
</div></li>
<li><strong>Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target</strong> -
<div>
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has made it clear that further development of antiviral therapies will be needed to combat additional SARS-CoV-2 variants or novel CoVs. Here, we describe small molecule inhibitors for SARS-CoV-2 Mac1, which counters ADP-ribosylation mediated innate immune responses. The compounds inhibiting Mac1 were discovered through high-throughput screening (HTS) using a protein FRET-based competition assay and the best hit compound had an IC50 of 14 M. Three validated HTS hits have the same 2-amide-3-methylester thiophene scaffold and the scaffold was selected for structure-activity relationship (SAR) studies through commercial and synthesized analogs. We studied the compound binding mode in detail using X-ray crystallography and this allowed us to focus on specific features of the compound and design analogs. Compound 27 (MDOLL-0229) had an IC50 of 2.1 M and was generally selective for CoV Mac1 proteins after profiling for activity against a panel of viral and human ADP-ribose binding proteins. The improved potency allowed testing of its effect on virus replication and indeed, 27 inhibited replication of both MHVa prototype CoV, and SARS-CoV-2. Furthermore, sequencing of a drug-resistant MHV identified mutations in Mac1, further demonstrating the specificity of 27. Compound 27 is the first Mac1 targeted small molecule demonstrated to inhibit coronavirus replication in a cell model. This, together with its well-defined binding mode, makes 27 a good candidate for further hit/lead-optimization efforts.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.08.28.555062v2" target="_blank">Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target</a>
</div></li>
<li><strong>Effect of Heparin and Tocilizumab in Patients with Severe COVID-19: The HEPMAB Randomized Clinical Trial</strong> -
<div>
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Background Clinical presentation of severe Coronavirus disease 2019 (COVID-19) is associated to an intense inflammatory response and thrombogenesis. The benefits of the association of interleukin-6 receptor blockade (tocilizumab) and therapeutic-dose anticoagulation remains unclear. We aimed to assess whether heparin and tocilizumab could effectively reduce inflammation and thrombogenesis in severe COVID-19 patients. Methods This is an open-label, multicenter, randomized, clinical trial, involving patients with severe COVID-19 infection. Eligible patients were randomly assigned in a 1:1:1:1 ratio to receive either therapeutic or prophylactic anticoagulation with heparin, with or without an intravenous single dose of tocilizumab. The participants in the study were assigned to one of the four distinct arms: 1) therapeutic anticoagulation; 2) prophylactic anticoagulation; 3) therapeutic anticoagulation plus a single intravenous dose of tocilizumab; and 4) prophylactic anticoagulation plus a single intravenous dose of tocilizumab. The primary outcome was clinical improvement at day 30, defined as a composite of hospital discharge and/or a reduction of at least 2 points of the modified ordinal scale of 7 points recommended by the World Health Organization. Results We enrolled 308 patients. Patients randomized to receive therapeutic anticoagulation more frequently had clinical improvement at day 30 when compared to the prophylactic anticoagulation patients [64/75 (85%) versus 51/80 (64%), odds ratio, 3.31; 95% confidence interval, 1.51; 7.26 P=0.003]. Major bleeding was more frequent in the therapeutic anticoagulation group (6.7%) and in the therapeutic anticoagulation plus tocilizumab group (5.0%), compared to the prophylactic anticoagulation group (P=0.02). All-cause mortality at day 30 was significantly lower in therapeutic anticoagulation group (9.3%), when compared to prophylactic anticoagulation group (28.7%), therapeutic anticoagulation plus tocilizumab group (21.5%) and prophylactic anticoagulation plus tocilizumab group (25.7%), P=0.02. Conclusions In this randomized clinical trial involving severe COVID-19 patients, therapeutic anticoagulation resulted in clinical improvement at 30 days. Even if therapeutic anticoagulation increased bleeding, it was associated with a reduced overall mortality. Tocilizumab did not provide additional benefits to heparin in COVID-19 patients.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.22.23300466v1" target="_blank">Effect of Heparin and Tocilizumab in Patients with Severe COVID-19: The HEPMAB Randomized Clinical Trial</a>
</div></li>
<li><strong>Synthesis and Assembly of mRNA-Bifunctional Lipid Nanoparticle (BLNP) for Selective Delivery of mRNA Vaccines to Dendritic Cells</strong> -
<div>
The fight against COVID-19 pandemic has gained a strong consensus about the importance of developing mRNA vaccines to rapidly respond to an outbreak. Several studies have shown that mRNA vaccines formulated as mRNA-lipid nanoparticles (LNPs) for vaccination can elicit a robust and efficient immune response. In this study, we report the preparation of mRNA-bifunctional lipid nanoparticles (mRNA-BLNPs) as vaccines for targeted delivery to dendritic cells (DCs) to improve safety and enhance immune response. Using this DC-targeted delivery system, mice immunized with SARS-CoV-2 spike mRNA-BLNP vaccine elicited a stronger immune response with higher titer of neutralizing IgG antibody response than the LNP-formulated vaccine against SARS-CoV-2. In addition, the spike mRNA-BLNP vaccine with deletion of glycosites in the stem elicited a broadly protective immune response against SARS-CoV-2 and variants. These findings suggest the importance and potential of developing DC-targeted mRNA vaccines to elicit broadly protective immune responses against human viruses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.26.572282v1" target="_blank">Synthesis and Assembly of mRNA-Bifunctional Lipid Nanoparticle (BLNP) for Selective Delivery of mRNA Vaccines to Dendritic Cells</a>
</div></li>
<li><strong>Inferring the sensitivity of wastewater metagenomic sequencing for pathogen early detection</strong> -
<div>
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Detecting novel pathogens at an early stage requires robust early warning that is both sensitive and pathogen-agnostic. Wastewater metagenomic sequencing (W-MGS) could meet these goals, but its sensitivity and financial feasibility depend on the relative abundance of novel pathogen sequences in W-MGS data. Here we collate W-MGS data from a diverse range of studies to characterize the relative abundance of known viruses in wastewater. We then develop a Bayesian statistical model to integrate these data with epidemiological estimates for 13 human-infecting viruses, and use it to estimate the expected relative abundance of different viral pathogens for a given prevalence or incidence in the community. Our results reveal pronounced variation between studies, with estimates differing by one to three orders of magnitude for the same pathogen: for example, the expected relative abundance of SARS-CoV-2 at 1% weekly incidence varied between 10^-7 and 10^-10. Integrating these estimates with a simple cost model highlights similarly wide inter-study and inter-pathogen variation in the cost of W-MGS-based early detection, with a mean yearly cost estimate of roughly $19,000 for a Norovirus-like pathogen and $2.9 million for a SARS-CoV-2-like pathogen at 1% incidence. The model and parameter estimates presented here represent an important resource for future investigation into the performance of wastewater MGS, and can be extended to incorporate new wastewater datasets as they become available.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.22.23300450v1" target="_blank">Inferring the sensitivity of wastewater metagenomic sequencing for pathogen early detection</a>
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<li><strong>Predicting poor mental health amongst older Syrian refugees in Lebanon during the COVID-19 pandemic: a multi-wave longitudinal study</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The COVID-19 pandemic has worsened pre-existing vulnerabilities among older Syrian refugees in Lebanon, potentially impacting their mental health. This study aimed to identify predictors of poor mental health amongst older Syrian refugees living in Lebanon during the pandemic. Methods: This study used repeated cross-sectional data from a multi-wave telephone survey (September 2020-March 2022). It was conducted among Syrian refugees aged 50 years or older from households that received assistance from a humanitarian organization. Poor mental health was defined as a Mental Health Inventory-5 score of 60 or less. Its trend over time was assessed using growth curve model; and, its predictors were identified using wave one data, through backwards stepwise logistic regression. The model9s internal validation was conducted using bootstrapping. Findings: There were 3,229 participants (median age=56 [IQR=53-62]) and 47.5% were female. At wave one, 76.7% had poor mental health, and this increased to 89.2% and to 92.7% at waves three and five, respectively (β = 0.52; 95% CI: 0.44-0.63; p-value&lt;0.001). Predictors for poor mental health were younger age, food insecurity, water insecurity, lack of legal status documentation, irregular employment, higher intensity of bodily pain, having debt, and having chronic illnesses. The final model demonstrated good discriminative ability and calibration. Interpretation: Mental health predictors were related to basic needs, rights and financial barriers. These allow humanitarian organizations to identify high risk individuals, organizing interventions, and addressing root causes to boost resilience and well-being among older Syrian refugees in Lebanon. Funding: ELRHA9s Research for Health in Humanitarian Crisis Programme.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.22.23300447v1" target="_blank">Predicting poor mental health amongst older Syrian refugees in Lebanon during the COVID-19 pandemic: a multi-wave longitudinal study</a>
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<li><strong>CitySEIRCast: An Agent-Based City Digital Twin for Pandemic Analysis and Simulation</strong> -
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The COVID-19 pandemic has dramatically highlighted the importance of developing simulation systems for quickly characterizing and providing spatio-temporal forecasts of infection spread dynamics that take specific accounts of the population and spatial heterogeneities that govern pathogen transmission in real-world communities. Developing such computational systems must also overcome the cold start problem related to the inevitable scarce early data and extant knowledge regarding a novel pathogen9s transmissibility and virulence, while addressing changing population behavior and policy options as a pandemic evolves. Here, we describe how we have coupled advances in the construction of digital or virtual models of real-world cities with an agile, modular, agent-based model of viral transmission and data from navigation and social media interactions, to overcome these challenges in order to provide a new simulation tool, CitySEIRCast, that can model viral spread at the sub-national level. Our data pipelines and workflows are designed purposefully to be flexible and scalable so that we can implement the system on hybrid cloud/cluster systems and be agile enough to address different population settings and indeed, diseases. Our simulation results demonstrate that CitySEIRCast can provide the timely high resolution spatio-temporal epidemic predictions required for supporting situational awareness of the state of a pandemic as well as for facilitating assessments of vulnerable sub-populations and locations and evaluations of the impacts of implemented interventions, inclusive of the effects of population behavioral response to fluctuations in case incidence. This work arose in response to requests from county agencies to support their work on COVID-19 monitoring, risk assessment, and planning, and using the described workflows, we were able to provide uninterrupted bi-weekly simulations to guide their efforts for over a year from late 2021 to 2023. We discuss future work that can significantly improve the scalability and real-time application of this digital city-based epidemic modelling system, such that validated predictions and forecasts of the paths that may followed by a contagion both over time and space can be used to anticipate the spread dynamics, risky groups and regions, and options for responding effectively to a complex epidemic.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.22.23300481v1" target="_blank">CitySEIRCast: An Agent-Based City Digital Twin for Pandemic Analysis and Simulation</a>
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<li><strong>Mild and moderate COVID-19 during Alpha, Delta and Omikron pandemic waves in urban Maputo, Mozambique, December 2020-March 2022: a population-based surveillance study</strong> -
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In sub-Saharan Africa, reported COVID-19 numbers have been lower than anticipated, even when considering populations9 younger age. The extent to which risk factors, established in industrialised countries, impact the risk of infection and of disease in populations in sub-Saharan Africa, remains unclear. We estimated the incidence of mild and moderate COVID-19 in urban Mozambique and analysed factors associated with infection and disease in a population-based surveillance study. During December 2020-March 2022, households of a population cohort in Polana Canico, Maputo, Mozambique, were contacted biweekly. Residents reporting any respiratory sign, anosmia, or ageusia, were asked to self-administer a nasal swab, for SARS-CoV-2 PCR testing. Of a subset of 1400 participants, dried blood spots were repeatedly collected three-monthly from finger pricks at home. Antibodies against SARS-CoV-2 spike glycoprotein and nucleocapsid protein were detected using an in-house developed multiplex antibody assay. We estimated the incidence of respiratory illness and COVID-19, and SARS-CoV-2 seroprevalence. We used Cox regression models, adjusting for age and sex, to identify factors associated with first symptomatic COVID-19 and with SARS-CoV-2 sero-conversion in the first six months. During 11925 household visits in 1561 households, covering 6049 participants (median 21 years, 54.8% female, 7.3% disclosed HIV positive), 1895.9 person-years were followed up. Per 1000 person-years, 364.5 (95%CI 352.8-376.1) respiratory illness episodes of which 72.2 (95%CI 60.6-83.9) COVID-19 confirmed, were reported. Of 1412 participants, 2185 blood samples were tested (median 30.6 years, 55.2% female). Sero-prevalence rose from 4.8% (95%CI 1.1-8.6%) in December 2020 to 34.7% (95%CI 20.2-49.3%) in June 2021, when 3.0% were vaccinated. Increasing age (strong gradient in hazard ratio, HR, up to 15.70 in &gt;=70 year olds, 95%CI 3.74-65.97), leukaemia, chronic lung disease, hypertension, and overweight increased risk of COVID-19. We found no increased risk of COVID-19 in people with HIV or tuberculosis. Risk of COVID-19 was lower among residents in the lowest socio-economic quintile (HR 0.16, 95%CI 0.04-0.64), with no or limited handwashing facilities, and who shared bedrooms (HR 0.42, 95%CI 0.25-0.72). Older age also increased the risk of SARS-CoV-2 seroconversion (HR 1.57 in 60-69 year olds, 95%CI 1.03-2.39). We found no associations between SARS-CoV-2 infection risk and socio-economic, behavioural factors and comorbidities. Active surveillance in an urban population cohort confirmed frequent COVID-19 underreporting, yet indicated that the large majority of cases were mild and non-febrile. In contrast to industrialised countries, deprivation did not increase the risk of infection nor disease.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.22.23300474v1" target="_blank">Mild and moderate COVID-19 during Alpha, Delta and Omikron pandemic waves in urban Maputo, Mozambique, December 2020-March 2022: a population-based surveillance study</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TDCS Stimulation After Covid-19 Infection</strong> - <b>Conditions</b>: COVID-19 <br/><b>Interventions</b>: Procedure: Transcranial Direct Stimulation <br/><b>Sponsors</b>: Istanbul Medipol University Hospital; Alanya Alaaddin Keykubat University <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of a Booster Vaccination With an Adapted Vaccine</strong> - <b>Conditions</b>: SARS-CoV2 Infection <br/><b>Interventions</b>: Biological: PHH-1V81; Biological: Comirnaty Omicron XBB1.5 <br/><b>Sponsors</b>: Hipra Scientific, S.L.U <br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Combined Modified RNA Vaccine Candidate Against COVID-19 and Influenza.</strong> - <b>Conditions</b>: Influenza; COVID-19 <br/><b>Interventions</b>: Biological: Influenza and COVID-19 Combination A; Biological: Licensed influenza vaccine; Biological: COVID-19 Vaccine; Biological: Influenza and COVID-19 Combination B; Biological: Placebo <br/><b>Sponsors</b>: BioNTech SE; Pfizer <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Transcranial Pulse Stimulation (TPS) in Post-COVID-19</strong> - <b>Conditions</b>: Post-COVID-19 Syndrome; Fatigue <br/><b>Interventions</b>: Device: Transcranial pulse stimulation Verum; Device: Transcranial pulse stimulation Sham <br/><b>Sponsors</b>: Medical University of Vienna; Campus Bio-Medico University <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluate the Efficacy and Safety of “Formosa 1-Breath Free (NRICM101)” in Subjects With the Symptoms of COVID-19 or Influenza-like Disease</strong> - <b>Conditions</b>: Influenza Viral Infections; COVID-19 <br/><b>Interventions</b>: Drug: Formosa 1-Breath Free (NRICM101); Drug: Placebo control drug <br/><b>Sponsors</b>: China Medical University Hospital; Tian-I Pharmaceutical,. Co. Ltd.; China Medical University, China; Qualitix Clinical Research Co., Ltd. <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of Booster Vaccination With Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell)</strong> - <b>Conditions</b>: COVID-19 <br/><b>Interventions</b>: Biological: Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell); Biological: Recombinant COVID-19 Variant Vaccine (Sf9 Cell); Biological: Placebo <br/><b>Sponsors</b>: WestVac Biopharma Co., Ltd.; WestVac Biopharma (Guangzhou) Co., Ltd. <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID</strong> - <b>Conditions</b>: Long Covid19; Exercise Intolerance, Riboflavin-Responsive <br/><b>Interventions</b>: Behavioral: Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Behavioral: Light Stretching/Breathing Exercises <br/><b>Sponsors</b>: Columbia University; New York University <br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong><em>In silico</em> study of inhibition activity of boceprevir drug against 2019-nCoV main protease</strong> - Boceprevir drug is a ketoamide serine protease inhibitor with a linear peptidomimetic structure that exhibits inhibition activity against 2019-nCoV main protease. This paper reports electronic properties of boceprevir and its molecular docking as well as molecular dynamics simulation analysis with protein receptor. For this, the equilibrium structure of boceprevir has been obtained by DFT at B3LYP and ωB97XD levels with 6-311+G(d,p) basis set in gas and water mediums. HOMO-LUMO and absorption…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Novel sofosbuvir derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective</strong> - The human coronavirus, SARS-CoV-2, had a negative impact on both the economy and human health, and the emerging resistant variants are an ongoing threat. One essential protein to target to prevent virus replication is the viral RNA-dependent RNA polymerase (RdRp). Sofosbuvir, a uridine nucleotide analog that potently inhibits viral polymerase, has been found to help treat SARS-CoV-2 patients. This work combines molecular docking and dynamics simulation (MDS) to test 14 sofosbuvir-based…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases</strong> - Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can lead to a cytokine storm, unleashed in part by pyroptosis of virus-infected macrophages and monocytes. Interleukin-6 (IL-6) has emerged as a key participant in this ominous complication of COVID-19. IL-6 antagonists have improved outcomes in patients with COVID-19 in some, but not all, studies. IL-6 signaling involves at least 3 distinct pathways, including classic-signaling, trans-signaling, and trans-presentation…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Excessive daytime sleepiness is associated with impaired antibody response to influenza vaccination in older male adults</strong> - CONCLUSION: Our results provide an additional and easily measured variable explaining poor vaccine effectiveness in older adults. Our results support that gaining sufficient sleep is a simple non-vaccine interventional approach to improve influenza immune responses in older adults. Our findings extend the literature on the negative influence of excessive daytime sleepiness on immune responses to influenza vaccination in older male adults.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS)</strong> - CONCLUSIONS: Ferritin is a clinically useful biomarker in ARDS and is associated with worse patient outcomes. These results provide support for prospective interventional trials of immunomodulatory agents targeting IL-18 in this hyperferritinaemic subgroup of patients with ARDS.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sutimlimab suppresses SARS-CoV-2 mRNA vaccine-induced hemolytic crisis in a patient with cold agglutinin disease</strong> - Cold agglutinin disease (CAD) is a rare form of acquired autoimmune hemolytic anemia driven mainly by antibodies that activate the classical complement pathway. Several patients with CAD experience its development or exacerbation of hemolysis after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or after receiving the SARS-CoV-2 mRNA vaccine. Therefore, these patients cannot receive an additional SARS-CoV-2 mRNA vaccination and have a higher risk of severe SARS-CoV-2…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of host proteins interacting with non-structural protein nsp9 of porcine epidemic diarrhea virus on viral replication</strong> - Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic virus that can cause acute intestinal infectious diseases in both piglets and fattening pigs. The virus encodes at least 16 non-structural proteins, including nsp9, which has been shown to bind to single-stranded RNA. However, its function and mechanism remain unclear. In this study, we aimed to identify potential host proteins that interact with PEDV nsp9 using immunoprecipitation combined with mass spectrometry. The interactions…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 in Dental Practice Is Prevented by Eugenol Responsible for the Ambient Odor Specific to Dental Offices: Possibility and Speculation</strong> - Dental professionals routinely work in proximity to patients even when either or both of them have suspected or confirmed COVID-19. The oral cavity also serves as a reservoir for SARS-CoV-2 because the virus is present in and replicates in oral secretions (saliva and gingival crevicular fluid), oral tissues (salivary gland and periodontal tissue), and oral microenvironments (gingival sulcus and periodontal pocket). Despite a high risk of SARS-CoV-2 infection, the prevalence of COVID-19 in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of Porcine Deltacoronavirus Entry and Replication by Cepharanthine</strong> - Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus (CoV) that mainly causes acute diarrhea/vomiting, dehydration, and mortality in piglets, possessing economic losses and public health concerns. However, there are currently no proven effective antiviral agents against PDCoV. Cepharanthine (CEP) is a naturally occurring alkaloid used as a traditional remedy for radiation-induced symptoms, but its underlying mechanism of CEP against PDCoV has remained elusive. The…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Does denosumab exert a protective effect against COVID-19? Results of a large cohort study</strong> - CONCLUSION: Our study confirms that denosumab may be safely continued in COVID-19 patients. RANK/RANKL inhibition seems associated with a reduced incidence of symptomatic COVID-19, particularly among the elderly.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques</strong> - Next-generation SARS-CoV-2 vaccines are needed that induce systemic and mucosal immunity. Murine pneumonia virus (MPV), a murine homolog of respiratory syncytial virus, is attenuated by host-range restriction in nonhuman primates and has a tropism for the respiratory tract. We generated MPV vectors expressing the wild-type SARS-CoV-2 spike protein (MPV/S) or its prefusion-stabilized form (MPV/S-2P). Both vectors replicated similarly in cell culture and stably expressed S. However, only S-2P was…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacies of S-nitrosoglutathione (GSNO) and GSNO reductase inhibitor in SARS-CoV-2 spike protein induced acute lung disease in mice</strong> - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially surfaced in late 2019, often triggers severe pulmonary complications, encompassing various disease mechanisms such as intense lung inflammation, vascular dysfunction, and pulmonary embolism. Currently, however, there’s no drug addressing all these mechanisms simultaneously. This study explored the multi-targeting potential of S-nitrosoglutathione (GSNO) and N6022, an inhibitor of GSNO reductase (GSNOR) on markers…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comparative transcriptome analysis of SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E identifying potential IFN/ISGs targets for inhibiting virus replication</strong> - INTRODUCTION: Since its outbreak in December 2019, SARS-CoV-2 has spread rapidly across the world, posing significant threats and challenges to global public health. SARS-CoV-2, together with SARS-CoV and MERS-CoV, is a highly pathogenic coronavirus that contributes to fatal pneumonia. Understanding the similarities and differences at the transcriptome level between SARS-CoV-2, SARS-CoV, as well as MERS-CoV is critical for developing effective strategies against these viruses.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity</strong> - The recent COVID-19 pandemic shows the critical need for novel broad spectrum antiviral agents. Scorpion venoms are known to contain highly bioactive peptides, several of which have demonstrated strong antiviral activity against a range of viruses. We have generated the first annotated reference transcriptome for the Androctonus amoreuxi venom gland and used high performance liquid chromatography, transcriptome mining, circular dichroism and mass spectrometric analysis to purify and characterize…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development</strong> - Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) are a major cause for acquired thrombophilia, but specific interventions preventing autoimmune aPL development are an unmet clinical need. While autoimmune aPL cross-react with various coagulation regulatory proteins, lipid-reactive and COVID-19 patient-derived aPL recognize the endo-lysosomal phospholipid lysobisphosphatidic acid (LBPA) presented by the cell surface expressed endothelial protein C receptor…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Colorado’s Top Court Kicked Trump Off the Ballot. Will the Supreme Court Agree?</strong> - A legal scholar analyzes how the nine Justices are likely to view the blockbuster decision. - <a href="https://www.newyorker.com/news/q-and-a/colorados-top-court-kicked-trump-off-the-ballot-will-the-supreme-court-agree">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>When Americans Are the Threat at the Border</strong> - Many people charged with trafficking in Tucson are U.S. citizens, suffering from the same problems of poverty and addiction that plague the rest of the country. - <a href="https://www.newyorker.com/news/daily-comment/when-americans-are-the-threat-at-the-border">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Netanyahu’s Right-Wing Critics See Israel’s Future</strong> - Danny Danon, the former Israeli Ambassador to the United Nations, believes there’s no path forward for a Palestinian state. - <a href="https://www.newyorker.com/news/q-and-a/how-netanyahus-right-wing-critics-see-israels-future">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An Unpermitted Shooting Range Upends Life in a Quiet Town</strong> - Residents of Pawlet, Vermont, were accustomed to calm and neighborly interactions. Then a new resident moved in. - <a href="https://www.newyorker.com/news/us-journal/one-mans-war-against-a-small-towns-rules">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Disturbing Impact of the Cyberattack at the British Library</strong> - The library has been incapacitated since October, and the effects have spread beyond researchers and book lovers. - <a href="https://www.newyorker.com/news/letter-from-the-uk/the-disturbing-impact-of-the-cyberattack-at-the-british-library">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The 14 predictions that came true in 2023 — and the 7 that didn’t</strong> -
<figure>
<img alt="An illustration filled with bright yellow check marks and dark blue X marks. Also included throughout the scene: SpaceX Starship, Joe Biden, the top of Donald Trump’s head, lab-grown meat, the flag of Finland, the flag of NATO, the U.S. supreme court building, and a syringe with antibiotics." src="https://cdn.vox-cdn.com/thumbor/NAjf3WBjpAz4rIdryGViU1IdQQQ=/480x0:1920x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/73006465/Predictions_2023_PaigeVickers_Vox.0.png"/>
<figcaption>
Paige Vickers/Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The 21 forecasts we made in 2023, revisited.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XIyEfQ">
Though the name might suggest otherwise, we are not technically in the “predicting the future” game at <a href="https://www.vox.com/future-perfect">Future Perfect</a>. We usually leave that to the pundits and analysts who will confidently tell you about who the next Republican nominee for president or NBA champion will be — and then conveniently forget should those predictions fail to come true.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ny5C9F">
But there is real epistemic value in not just trying to predict what’s to come, but putting a specific probability on that prediction — and then, just as importantly, evaluating whether and why you were right (or wrong) after the fact. It’s an intellectual exercise in both rigor and humility, and one that is <a href="https://www.nytimes.com/2023/10/08/technology/prediction-markets-manifold-manifest.html">becoming increasingly valuable</a> in our part of the media.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9wUBvf">
So how did <a href="https://www.vox.com/future-perfect/2023/1/2/23494204/biden-trump-putin-supreme-court-2023-predictions">our 2023 forecasts</a> do? Not bad — 14 correct predictions to 7 misfires. (Note that we had to invalidate two predictions from 2023’s list, on the number of poultry culled because of bird flu and Beyond Meat’s stock price, because of problems in how the predictions were formulated.) Politics proved relatively easy — yes, Joe Biden would run for reelection and would remain the Democratic frontrunner; no, not a single Republican would seriously challenge Donald Trump’s hold on the party and the likely nomination.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JDCR4t">
Economics proved more difficult, as we and just about every other analyst failed to foresee that the US would escape recession even as it brought down inflation. And <a href="https://www.vox.com/future-of-meat">tech</a> turned out to confound some of our expectations, in part because technologies like lab-grown meat haven’t advanced as rapidly as we’d forecast, and in part because bad things, like the ongoing <a href="https://www.vox.com/future-perfect/23963820/bird-flu-surge-us-ventilation-shutdown-veterinarians">avian flu outbreaks</a>, haven’t been quite as bad as we thought.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w41uiy">
As I do every year, I’ll quote my colleague Dylan Matthews: “<a href="https://www.vox.com/future-perfect/22812197/predict-2021-trump-biden-covid-germany">Predicting the future is a skill</a> at which some people are dramatically better than others, and practicing is one of the best ways to improve at it.” Check back with us on January 1, when we unveil our predictions for 2024. <em>—Bryan Walsh</em>
</p>
<h3 id="W5dTjI">
United States
</h3>
<h4 id="UEkQAo">
<strong>Joe Biden will be the frontrunner for the Democratic nomination heading into 2024 (70 percent) — RIGHT </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="j3kSCd">
Naturally, 2023 featured a lot of speculation and suggestions about dramatic change-ups on the Democratic side: should Biden <a href="https://apnews.com/article/ap-norc-poll-biden-2024-presidential-prospects-c843c5af6775b4c8a0cff8e2b1db03f6">even run again</a>? Should he <a href="https://www.joshbarro.com/p/biden-should-pick-a-new-running-mate">replace Kamala Harris with Michigan Gov. Gretchen Whitmer</a>? Would a top-tier alternative like <a href="https://www.theguardian.com/us-news/2023/nov/12/california-gavin-newsom-biden-president-2024">California Gov. Gavin Newsom</a> challenge him?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yJDSN5">
Ultimately none of that happened, and the strongest challenger he got was Rep. <a href="https://www.cnn.com/2023/10/26/politics/dean-phillips-presidential-campaign-launch/index.html">Dean Phillips</a> of Minnesota, which must be who pollsters mean when they ask respondents their views of a “generic Democrat.” As a result, the prediction markets and platforms, from the crypto-based <a href="https://polymarket.com/event/who-will-win-the-us-2024-democratic-presidential-nomination">Polymarket</a> to the staid and professional <a href="https://www.metaculus.com/questions/11379/2024-democrat-nominee-for-us-prez/">Metaculus</a> to the goofy and anarchic <a href="https://manifold.markets/MichaelWheatley/who-will-win-the-us-2024-democratic">Manifold</a> to the old standby <a href="https://www.predictit.org/markets/detail/7057/Who-will-win-the-2024-Democratic-presidential-nomination">PredictIt</a>,<strong> </strong>give Biden overwhelming odds to be renominated. This was the standard I chose for determining if Biden was the “frontrunner,” so I feel like I nailed this one. And, for what it’s worth, <a href="https://projects.fivethirtyeight.com/polls/president-primary-d/2024/national/">the polls agree</a>.<em> —Dylan Matthews</em>
</p>
<h4 id="dwPrgA">
<strong>Donald Trump will be the frontrunner for the Republican nomination heading into 2024 (60 percent) —RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="O97WRv">
While a year later it feels inevitable that Trump would be crushing his rivals and that <a href="https://www.vox.com/ron-desantis">the Ron DeSantis bubble</a> would’ve popped almost immediately, this was not exactly obvious in late 2022, which accounts for my relatively unconfident prediction. Trump, after all, was under investigation by several prosecutors, seemed likely to be indicted by a few of them, and is (no less than Joe Biden) showing his age these days.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rhLXl3">
But you can never go broke betting against Trump in a GOP primary, even after he <em>was</em> <a href="https://www.vox.com/trump-investigations/23832341/trump-charges-prison-time-sentence-indictments">indicted several times</a>, and so <a href="https://polymarket.com/event/who-will-win-the-us-2024-republican-presidential-nomination">Polymarket</a> and <a href="https://www.predictit.org/markets/detail/7053/Who-will-win-the-2024-Republican-presidential-nomination">all</a> <a href="https://manifold.markets/PC/who-will-be-the-republican-presiden-7bf11c066154">the</a> <a href="https://www.metaculus.com/questions/11370/2024-republican-nominee-for-us-prez/">rest</a> still put him as a decisive frontrunner as of this writing. <em>—DM</em>
</p>
<h4 id="VXVpZ4">
<strong>The </strong><a href="https://www.vox.com/scotus"><strong>Supreme Court</strong></a><strong> will rule that </strong><strong>affirmative action</strong><strong> is unconstitutional (70 percent) — WRONG </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qWkH3C">
This may seem like a case where I was obviously right — the Court <a href="https://www.vox.com/policy-and-politics/23405267/affirmative-action-supreme-court-ruling-race-harvard-unc-chapel-hill"><em>did</em> rule affirmative action unconstitutional</a> in most cases — but you have to look at the fine print. Here’s how I characterized my <a href="https://www.vox.com/future-perfect/2023/1/2/23494204/biden-trump-putin-supreme-court-2023-predictions">prediction</a>:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gbBFkh">
The reason I’m not more confident is due to a nuance [my Vox colleague Ian] Millhiser noted, which is that [Chief Justice John] Roberts appeared open to racial preferences at military academies, noting the federal government’s argument that the military needs a diverse officer corps to succeed. If such a carve-out is included in the ultimate ruling, my prediction here will be wrong: I’m predicting they’ll strike down affirmative action across the board at public or publicly funded institutions.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MZGW0G">
The Supreme Court <em>did </em>include such a carveout allowing for racial preferences at service academies. Here is Roberts, in footnote 4 of <a href="https://www.supremecourt.gov/opinions/22pdf/20-1199_hgdj.pdf">his opinion</a>:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Rj9Ok8">
The United States as amicus curiae contends that race-based admissions programs further compelling interests at our Nation’s military academies. No military academy is a party to these cases, however, and none of the courts below addressed the propriety of race-based admissions systems in that context. This opinion also does not address the issue, in light of the potentially distinct interests that military academies may present.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="parbA5">
In her dissent, Sonia Sotomayor interprets this as meaning “the Court exempts military academies from its ruling.” I predicted they would not do this, so I got this wrong. I apologize to the <a href="https://manifold.markets/a/the-supreme-court-will-rule-that-af#kU9i4dYFJCB6KPmQg2q9">good people at Manifold Markets</a> whom I confused on this. <em>—DM</em>
</p>
<h4 id="p7rnKI">
<strong>The US will not meet its target for refugee admissions this fiscal year (80 percent) — RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zw4tGt">
Unfortunately, this prediction was right. President Biden had set the refugee admissions target at 125,000 for fiscal year 2023 but <a href="https://www.migrationpolicy.org/programs/data-hub/charts/us-refugee-resettlement">ended up resettling roughly 60,000</a>. Even getting halfway to the target proved just out of reach.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vdzBQV">
America’s resettlement infrastructure still hasn’t fully recovered from the Trump administration, which <a href="https://www.vox.com/future-perfect/2022/6/14/23162982/refugees-united-states-displaced-people-afghanistan-ukraine-biden-trump">gutted it</a>. Biden <a href="https://www.vox.com/policy-and-politics/22422368/biden-refugee-cap-resettlement">promised</a> to restaff the government agencies that do resettlement and reopen the offices that had been shuttered, but advocates say the rebuild has been too slow.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YorzEM">
Yes, the US has welcomed some groups — like Afghans, Ukrainians, and Venezuelans — but note that those who came to the US via the legal process known as <a href="https://www.vox.com/22636742/afghan-siv-refugee-resettlement-biden">humanitarian parole</a> only get stays of two years. They don’t count toward the number of refugees resettled, as refugees are given a path to permanent residency. <em>—Sigal Samuel</em>
</p>
<h4 id="14HRwk">
<strong>The US will slip into recession during 2023 (70 percent) — WRONG</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w0hOmZ">
I was very wrong on this one. (Bad for me, good for the commonwealth.) At this point, it now appears that the <a href="https://www.vox.com/economy">US economy</a> will likely have <a href="https://www.conference-board.org/research/us-forecast">grown by more than 2 percent</a> over the course of 2023, which, clearly, does not qualify as a recession. Despite concerns that the Federal Reserve’s campaign to quash inflation through interest rate hikes would inevitably squash growth, the US economy remained startlingly resilient in 2023, <a href="https://home.treasury.gov/news/featured-stories/the-us-economy-in-global-context#:~:text=The%20U.S.%20economy%20in%202023,market%20resilience%2C%20and%20slowing%20inflation.">outperforming expectations across the board</a>. Fed Chair Jerome Powell couldn’t have set up the country for a softer landing with a warehouse full of Tempur-Pedic mattresses.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LBiaZS">
But if I was wrong, I wasn’t alone. Recession expectations <a href="https://www.bankrate.com/banking/federal-reserve/economic-indicator-survey-recession-risks-january-2023/">were historically aligned</a> — everyone from Wall Street analysts to Fed economists to <a href="https://www.youtube.com/watch?app=desktop&amp;v=65Fw4k4Fyqs">intense guys who really want you to buy gold</a> largely assumed a recession was an inevitability sometime in 2023. Heck, <a href="https://www.bankrate.com/banking/savings/americans-experiencing-silent-recession/#:~:text=Almost%203%20in%205%20(or,%2C%20region%2C%20gender%20and%20race.">according to one survey</a>, 59 percent of Americans feel like the US is in a recession <em>right now</em>, which is a whole other thing. (See above: it is not.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0aQuvV">
You can’t really blame the prognosticators. The US <a href="https://www.vox.com/policy-and-politics/2022/12/15/23508155/federal-reserve-inflation-recession-soft-landing">has almost never managed</a> to curb inflation at this level without slipping into a recession. Economically speaking, what has happened in 2023 is akin to water suddenly flowing uphill — which is probably why a lot of analysts are still <a href="https://www.cnbc.com/2023/11/29/possible-us-recession-strategists-give-cautious-predictions-for-2024.html">worried about the possibility of a recession</a> next year. We’ll see if Powell can pull another rabbit out of his hat. —<em>BW</em>
</p>
<h4 id="4XJZ7o">
<strong>Inflation in the US will exceed 3 percent (60 percent) — RIGHT </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0s8gbH">
My <a href="https://www.vox.com/future-perfect/22824620/predicting-midterms-covid-roe-wade-oscars-2022">definition</a> of inflation for my predictions is the same as <a href="https://www.bea.gov/data/personal-consumption-expenditures-price-index-excluding-food-and-energy">the one used by the Federal Reserve</a>: the price increases of “personal consumption expenditures,” excluding food and energy. More specifically, I committed to using an average of the first three quarters of the year, as the fourth quarter data is not yet available.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o2atn1">
Well, the first three quarters’ inflation rates were 5.0, 3.7, and 2.3 (see <a href="https://www.bea.gov/sites/default/files/2023-11/gdp3q23_2nd.pdf#page=12">row 34 here</a> on page 12), for an average of 3.67 percent. That is, for sure, above 3 percent, even as it was rapidly falling. Even adding in October’s data results in <a href="https://apps.bea.gov/iTable/?reqid=19&amp;step=3&amp;isuri=1&amp;1921=survey&amp;1903=84&amp;_gl=1*oas7na*_ga*MTc1MTE3Mzk3OS4xNzAyMzA4NDE3*_ga_J4698JNNFT*MTcwMjMwODQxNy4xLjEuMTcwMjMwOTMzOC4wLjAuMA..#eyJhcHBpZCI6MTksInN0ZXBzIjpbMSwyLDMsM10sImRhdGEiOltbIk5JUEFfVGFibGVfTGlzdCIsIjg0Il0sWyJDYXRlZ29yaWVzIiwiU3VydmV5Il0sWyJGaXJzdF9ZZWFyIiwiMjAyMyJdLFsiTGFzdF9ZZWFyIiwiMjAyMyJdLFsiU2NhbGUiLCIwIl0sWyJTZXJpZXMiLCJNIl1dfQ==">average monthly inflation</a> of 0.28 percent for the year, or 3.36 percent in annual terms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cGjXUT">
I think 2023 will be the year that inflation finally gets back to the 2 percent range, which is an impressive achievement for the Fed given no recession has occurred. But for 2023, it was still fairly high. <em>—DM</em>
</p>
<h4 id="lYgDt3">
<strong>There will be no Supreme Court vacancies in 2023 (90 percent) — RIGHT </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JR1Luk">
Given the nine justices’ ages, wealth, and education levels, there was a less than 11 percent chance that a sitting Supreme Court justice would’ve died this year. That didn’t happen, nor did any sitting justice retire.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VPxJou">
That could change next year. There’s <a href="https://www.vox.com/policy-and-politics/23507944/supreme-court-sonia-sotomayor-elena-kagan-ruth-bader-ginsburg-retire">growing pressure</a> for 69-year-old liberal Justice Sonia Sotomayor to leave the court before Republicans likely gain control of the Senate in 2024 and hold power over Supreme Court nominations for the next six to eight years, or longer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lX2YYi">
That pressure will grow in 2024, in what’s already gearing up to be a wild ride of an election year. If Sotomayor were to die while Republicans control the Senate, it could lock in a conservative 7-2 majority for years and <a href="https://www.vox.com/2022/6/25/23181976/case-against-the-supreme-court-of-the-united-states">further erode</a> American democracy. <em>—Kenny Torrella</em>
</p>
<h3 id="8B9WVm">
</h3>
<h3 id="cnXNMV">
The world
</h3>
<h4 id="qh9WkE">
<strong>Vladimir Putin will still be president of </strong><strong>Russia</strong><strong> (80 percent) — RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kpuZHu">
Putin recently <a href="https://www.cbsnews.com/news/putin-running-for-re-election-almost-sure-to-win-another-6-year-term/">announced his reelection bid</a> for a fifth term as Russia’s president, and given the average life expectancy of Russian opponents of his regime, I give him very good odds.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5TTRFU">
My estimate of 20 percent odds of Putin losing power was based on a suspicion that the stalemate in <a href="https://www.vox.com/russia-invasion-ukraine">Ukraine</a>, and the massive economic and human toll it’s wreaked on Russia, would make him vulnerable. That was correct, and in June the mercenary Wagner Group and its colorful leader <a href="https://www.vox.com/world-politics/2023/6/24/23772391/russia-wagner-group-moscow-putin-pregozhin-lukashenko">Yevgeny Prigozhin openly mutinied against Putin</a> and began to march on Moscow. For a brief moment, it appeared they would be able to take the city and perhaps overthrow Putin.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3JIO4m">
But Prigozhin — who was not an opponent of the war but instead a believer that he could run it better than Putin — blinked and called off the march. Putin, at first, seemed to welcome him back into the fold. Then, on August 23, two months after the mutiny, the plane Prigozhin was flying in <a href="https://www.nytimes.com/2023/08/24/us/politics/plane-crash-prigozhin-explosion.html">crashed due to an explosion on board</a>. Putin has suggested that Prigozhin died when a <a href="https://www.wsj.com/world/russia/putin-says-grenade-fragments-found-in-wreckage-of-prigozhins-plane-209942e5">cocaine-fueled hand grenade-tossing party</a> aboard the plane got out of hand. As plausible as that seems, I agree with other analysts that it seems more likely <a href="https://foreignpolicy.com/2023/09/05/yevgeny-prigozhin-assassination-vladimir-putin-wagner-deal-revenge/">Putin just killed the guy</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PTPFJz">
In any case, Putin was not able to prevent the pressures of the war from building into a dangerous mutiny. He <em>was</em> able to crush that mutiny, though, and to send a message that any future attempts will end in fiery death.<em> —DM</em>
</p>
<h4 id="rOH9Td">
<strong>China</strong><strong> will not launch a full-scale invasion of Taiwan (90 percent) — RIGHT </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CLRnlI">
It would be an exaggeration to say that Chinese relations with Taiwan are currently good. The Democratic Progressive Party — the more pro-independence, anti-Beijing party on the island — is currently <a href="https://www.theguardian.com/commentisfree/2023/dec/09/how-much-trouble-is-xi-really-in-outgunned-taiwan-may-be-about-to-find-out">leading polls for next month’s presidential election</a>, albeit narrowly. China keeps <a href="https://www.reuters.com/world/asia-pacific/taiwan-again-reports-chinese-carrier-group-taiwan-strait-election-looms-2023-12-11/">sending carriers through the Taiwan Strait</a>, and is reportedly <a href="https://www.cnn.com/2023/12/08/asia/taiwan-intelligence-china-leaders-meeting-election-interference-intl-hnk/index.html">meddling in the election</a> to try to help the pro-unification Kuomintang party.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LTgrmk">
But there have not been any indications that China is amassing the troops it needs for a full-scale amphibious assault, or the ships it would need for a blockade meant to force Taiwanese capitulation. And thank goodness; the world hardly needs another high-casualty war right now. <em>—DM</em>
</p>
<h4 id="Yff8UD">
<strong>At least one new country will join NATO (90 percent) — RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NVM1Kd">
Finland, which despite being a liberal democracy remained so diplomatically close to the Soviet Union that the country’s name became <a href="https://en.wikipedia.org/wiki/Finlandization">a term of diplomatic art</a>, joined the <a href="https://www.nato.int/cps/en/natohq/news_213448.htm">North Atlantic Treaty Organization on April 4</a>, in the most dramatic reaction of any country to Russia’s assault on Ukraine. The country, which was a Russian possession until 1917, <a href="https://www.pbs.org/newshour/world/newest-nato-member-finland-starts-building-fence-on-russian-border">shares an 832-mile border</a> with Russia, which can now host NATO troops and bases from allied nations to deter Russian incursions west.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P901NW">
Sweden seemed likely to formally join this year as well, but it was blocked due to foot-dragging by <a href="https://apnews.com/article/hungary-sweden-nato-accession-trukey-orban-erdogan-245d9d480bbae93606a38e5ce2c833ed">Hungary</a> and <a href="https://www.bloomberg.com/news/articles/2023-12-11/sweden-nato-membership-turkey-says-no-rush-to-finalize-bid?embedded-checkout=true">Turkey</a> over Sweden’s <a href="https://www.politico.eu/article/hungary-viktor-orban-play-spoilsport-nato-accession-finland-sweden/">criticism of Hungarian autocrat Viktor Orbán</a> and its <a href="https://www.france24.com/en/europe/20230612-with-eye-on-nato-membership-sweden-agrees-to-extradite-self-proclaimed-pkk-supporter-to-turkey">past refusal to extradite Kurdish activists to Turkey</a>, respectively. It still seems likely to join in 2024, but its path is a little more circuitous than Finland’s. <em>—DM</em>
</p>
<h4 id="seIuB3">
<strong>Finland will remain the world’s happiest country, while America won’t crack the top dozen (75 percent) — RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bvwgb2">
Every year, the World Happiness Report ranks countries in terms of the happiness of their populations. It’s part of a burgeoning movement to <a href="https://www.vox.com/the-highlight/23862090/subjective-wellbeing-wealth-philanthropy-gdp-happiness-givewell">pay more attention to indicators of subjective well-being</a> as opposed to just raw GDP.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PmzJo7">
This year’s <a href="https://worldhappiness.report/ed/2023/world-happiness-trust-and-social-connections-in-times-of-crisis/#ranking-of-happiness-2020-2022">country rankings</a> didn’t surprise me at all. Finland held on to the top spot on the list, thanks to its well-run public services, high levels of trust in authority, and low levels of crime and inequality, <a href="https://www.theguardian.com/world/2022/mar/19/finland-named-worlds-happiest-country-for-fifth-year-running#:~:text=%E2%80%9CMany%20things%20are%20undeniably%20good,levels%20of%20crime%20and%20inequality.">among other things</a>. I was pretty confident that would be the case because the Nordic nation had already been the happiest country for five years running, and last year <a href="https://www.cnbc.com/2022/03/19/world-happiness-ranking-2022-where-the-united-states-ranks-now.html">researchers noted</a> that its score was “significantly ahead” of every other country.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7bBizX">
Meanwhile, America’s ranking improved very slightly — from 16th place in 2022 to 15th place in 2023 — but, as I predicted, it didn’t make it into the top dozen spots. It never has, which is, um, really something to reflect on.<em> —SS</em>
</p>
<h3 id="Yz2gwy">
</h3>
<h3 id="ivy7w1">
Science and technology
</h3>
<h4 id="RxNPph">
<strong>A psychedelic-based </strong><strong>mental health</strong><strong> treatment will win US regulatory approval (60 percent) — WRONG</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Fntd2Z">
Based on indications from <a href="https://www.pharmacytimes.com/view/expert-mdma-is-very-likely-to-be-fda-approved-for-ptsd-by-the-end-of-2023">experts</a> and the <a href="https://theintercept.com/2022/07/26/mdma-psilocybin-fda-ptsd/">government</a>, I suspected there was a decent chance regulators would approve MDMA for treatment of PTSD this year. And after publishing some promising <a href="https://www.nytimes.com/2023/09/14/health/mdma-ptsd-psychedelics.html">study results</a>, the Multidisciplinary Association for Psychedelic Studies did indeed <a href="https://mapsbcorp.com/news/mdma-for-ptsd-fda-submission/">file for Food and Drug Administration approval</a> of MDMA-assisted therapy for PTSD. But it’ll be months before we get a decision out of the FDA. <em>—SS</em>
</p>
<h4 id="yQvXNp">
<strong>The US will not approve a nasal vaccine for </strong><strong>Covid-19</strong><strong> (90 percent) — RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K5gIFN">
Even though we’ve been told that Covid-19 vaccines delivered through the nose <a href="https://www.nytimes.com/2022/02/02/health/covid-vaccine-nasal.html">may prevent more infections</a> than shots in arms, and even though Covid-19 nasal vaccines created by American researchers have been tested in animals, the US doesn’t have them and probably won’t anytime soon. One big reason is a <a href="https://www.nytimes.com/2022/11/18/health/covid-nasal-vaccines-warp-speed.html">lack of funding</a>: Biden asked Congress for more money for next-generation vaccines, but Republicans resisted. <em>—SS</em>
</p>
<h4 id="0suqq7">
<strong>An </strong><a href="https://www.vox.com/2023/4/28/23702644/artificial-intelligence-machine-learning-technology"><strong>AI</strong></a><strong> company will knowingly release a text-to-image or text-to-video model that exhibits bias (90 percent) — RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lVoTjT">
When I made this prediction, I specified that I would judge an AI company to have “knowingly” released a biased model if the company acknowledges in a system card or similar that the product exhibits bias.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W0TXbn">
Well, in October, OpenAI released DALL-E 3, and stated in the model’s<a href="https://cdn.openai.com/papers/DALL_E_3_System_Card.pdf"> system card</a>: “Bias remains an issue with generative models including DALL·E 3, both with and without mitigations. DALL·E 3 has the potential to reinforce stereotypes … We additionally see a tendency toward taking a Western point-of-view more generally.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HZtPn2">
Other AI models, like Google’s recently unveiled Gemini,<a href="https://www.vox.com/future-perfect/22916602/ai-bias-fairness-tradeoffs-artificial-intelligence"> almost certainly exhibit bias, too</a> — it’s just that, unlike OpenAI, Google is not saying what’s under the hood. —<em>SS</em>
</p>
<h4 id="MoZdow">
<strong>OpenAI will release GPT-4 (60 percent) — RIGHT </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g9zr27">
<a href="https://www.theverge.com/2023/3/14/23638033/openai-gpt-4-chatgpt-multimodal-deep-learning">GPT-4, released on March 14</a>, was not a dramatic sea change in ability compared to GPT-3.5 that preceded it. But it’s quite a bit better, especially combined with other improvements that OpenAI rolled out this year: <a href="https://www.datacamp.com/tutorial/how-to-use-chat-gpt-code-interpreter">Code Interpreter</a>, which can generate working code to solve problems based on plain English prompts; <a href="https://openai.com/blog/dall-e-3-is-now-available-in-chatgpt-plus-and-enterprise">DALL-E 3</a>, the latest OpenAI image generation model now integrated into ChatGPT; <a href="https://help.openai.com/en/articles/8555510-gpt-4-turbo">GPT-4 Turbo</a>, yet another refinement of the core model; and <a href="https://www.theverge.com/2023/11/6/23948957/openai-chatgpt-gpt-custom-developer-platform">GPTs</a>, a program that enables users to train their own custom version of GPT-4 tailored to a particular task.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gaprB5">
The <a href="https://www.vox.com/technology/2023/11/20/23969589/openai-sam-altman-fired-microsoft-chatgpt-emmett-shear-silicon-valley">boardroom chaos that consumed the company</a> in November seems, in retrospect, to be mostly a blip in the context of its big product releases. It remains by far the dominant AI company, and with the aggressively commercializing <a href="https://www.vox.com/future-perfect/2023/11/21/23971765/openai-sam-altman-microsoft">Sam Altman</a> now more firmly in charge than ever, it shows no signs of slowing down.<strong> </strong><em>—DM </em>
</p>
<h4 id="yfjFGu">
<a href="https://www.vox.com/spacex"><strong>SpaceX</strong></a><strong>’s Starship will reach orbit (70 percent) — WRONG</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X4RQkP">
SpaceX certainly <em>tried</em> to reach orbit in 2023. It launched the Starship twice, on <a href="https://en.wikipedia.org/wiki/SpaceX_Starship_integrated_flight_test_1">April 20</a> and <a href="https://en.wikipedia.org/wiki/SpaceX_Starship_integrated_flight_test_2">November 18</a>. The first saw the vehicle explode after <a href="https://www.nature.com/articles/d41586-023-01377-3">reaching 39 km</a>, and the second saw the second stage <a href="https://apnews.com/article/spacex-starship-test-flight-launch-37c0893ddf605270b16a33ae64d69a85">reach 148 km</a> before a safety procedure led it to self-destruct. But neither entered orbit; even a successful launch, by SpaceX’s own standards, would not have led to a full orbit of the Earth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G4wur7">
I think my failure here was partly raising a poorly framed question. What I meant, I think, was “will SpaceX have a Starship test that goes well.” I think the November test went well by many metrics. But as I phrased the question, I set the bar implausibly high, and SpaceX failed to meet it. <em>—DM</em>
</p>
<h3 id="2SZ2Hb">
</h3>
<h3 id="95olbv">
Animal welfare
</h3>
<h4 id="N2x9Qj">
<strong>At least three lab-grown meat companies will begin selling their products in the US (50 percent) — WRONG </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="edxlsB">
Two lab-grown, or “cell-cultivated” meat, companies began selling their products in the US in 2023. I was wrong here, but I had hedged my bet with 50 percent confidence because I had heard so much uncertainty from people in the sector about which companies would first get approval from US regulators to sell their products, and when.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="THRbI5">
Two of the startups with the most funding, Upside Foods and GOOD Meat — both based in the San Francisco Bay Area — <a href="https://www.vox.com/future-perfect/23768224/eat-just-good-meat-upside-cell-cultivated-chicken-lab-grown">gained approval</a> the same day in June. Both make chicken derived from chicken cells, which they feed a mix of sugars, amino acids, salts, vitamins, minerals, and other ingredients for several weeks until they can be harvested as animal fat and muscle tissue.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r0Nc5J">
The startups are selling their products to consumers, but in <a href="https://www.vox.com/future-perfect/23801730/cell-cultivated-lab-grown-meat-jose-andres-upside-eat-just">very limited quantities</a> at just one US restaurant per company. They still have a long way to go to figuring out if they can scale their technology to compete with conventional meat on cost. But overcoming the regulatory hurdle is part of the battle in bringing a product to market, and this nascent field demonstrated their processes are safe and regulatory-compliant. <em>—KT</em>
</p>
<h4 id="q7jITF">
<strong>The Supreme Court will rule in favor of the pork industry in </strong><em><strong>National Pork Producers Council v. Ross</strong></em><strong> (70 percent) — WRONG</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xHbaQg">
In 2018, California voters passed a law, known as <a href="https://www.vox.com/future-perfect/2022/10/9/23393017/supreme-court-pork-pigs-prop-12-california-animal-welfare">Proposition 12</a>, that requires pork sold in the state to come from pigs given more space — essentially, cage-free conditions — whether those pigs were raised in California or not. A pork industry group, the National Pork Producers Council, sued the state over it, and the case made its way up to the US Supreme Court. I predicted with high confidence that the business-friendly Court would rule in favor of the pork producers, but instead — to my shock and delight — they sided with California and the pigs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KjHHfT">
The case <a href="https://farmanimalwelfare.substack.com/p/a-big-supreme-court-win-for-farm">hinged</a> not on <a href="https://www.vox.com/animal-welfare">animal welfare</a>, but on states’ rights, and whether Prop 12 was unfairly forcing farmers in other states to give pigs more space if they still wanted to sell their pork in California. All nine justices agreed Prop 12 was constitutionally sound in this regard. The pork industry also claimed that the financial trouble the law imposed on <a href="https://www.vox.com/future-perfect/2022/10/9/23393017/supreme-court-pork-pigs-prop-12-california-animal-welfare">producers</a> outweighed any benefits the law delivered to Californians. On this matter, the justices voted to uphold Prop 12 and scrambled the political divide on the Court. Conservative Justices Neil Gorsuch, Amy Coney Barrett, and Clarence Thomas joined liberal Justices Sonia Sotomayor and Elena Kagan, for the 5-4 decision.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="szZiE9">
It was a momentous decision for the future of farm animal welfare, helping to ensure similar laws around the country remain intact and giving animal advocates a level of certainty that it’ll be harder to challenge future laws. <em>—KT </em>
</p>
<h4 id="G49AqE">
<strong>Antibiotics sales for farmed animals will increase in 2022 (65 percent) — RIGHT</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XyupbQ">
Farmed animals are raised in unsanitary, overcrowded conditions. Knowing that disease spread is all but inevitable, meat producers <a href="https://www.vox.com/future-perfect/2023/1/8/23542789/big-meat-antibiotics-resistance-fda">routinely feed animals antibiotics</a>. A terrifying result of routine antibiotic feeding is that bacteria are mutating and developing <a href="https://www.vox.com/future-perfect/2020/10/14/21364965/antibiotics-factory-farms-bacterial-infections">resistance to these antibiotics</a>, making them less effective in treating common conditions in humans, like sepsis, urinary tract infections, and tuberculosis.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uQEunr">
Public health experts have been <a href="https://www.who.int/news/item/07-11-2017-stop-using-antibiotics-in-healthy-animals-to-prevent-the-spread-of-antibiotic-resistance#:~:text=WHO%20is%20recommending%20that%20farmers,their%20unnecessary%20use%20in%20animals.">calling on meat companies</a> to cut back on antibiotic use, and on the FDA to enact stricter regulations on the issue like its European counterparts have done. I predicted neither the FDA’s modest actions nor industry’s voluntary agreements over the past few years would have made a difference in cutting antibiotic usage in the meat business, and I was right.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="caDL9x">
Earlier this month, the FDA released <a href="https://www.fda.gov/animal-veterinary/antimicrobial-resistance/2022-summary-report-antimicrobials-sold-or-distributed-use-food-producing-animals">data</a> that showed in 2022 there was a 4 percent increase in sales of medically important antibiotics to the livestock sector. To the FDA’s credit, regulations it passed in the mid-2010s did help bring sales down for a couple years, but they’ve been <a href="https://www.vox.com/future-perfect/2023/1/8/23542789/big-meat-antibiotics-resistance-fda">ticking back up</a> every year since 2017. <em>—KT</em>
</p>
<h3 id="zvo5OH">
</h3>
<h3 id="ATBzBV">
Entertainment and culture
</h3>
<h4 id="Q7BQol">
<em><strong>Top Gun: Maverick </strong></em><strong>will not win Best Picture (75 percent) — RIGHT </strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Vrcpsk">
Pfft, come on! Yes, the Academy of Motion Picture Arts and Sciences did deign to gift a Best Picture nomination to this paean to the American military-industrial complex and the medical wonders of <a href="https://www.menshealth.com/uk/fitness/a754595/tom-cruises-secrets-of-youth/">Tom Cruise’s anti-aging regimen</a>. But let’s be real — the mysteriously unnamed foreign adversary in the film was more likely to blast Pete “Maverick” Mitchell out of the sky than give the Best Picture to an action movie that, arguably, saved movies as an industry coming out of Covid. Seventy-five percent certainty was, in retrospect, way too low.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="djb7pr">
After all, the last time the Academy gave the Best Picture statuette to a mega-popular action film <a href="https://www.youtube.com/watch?v=AoKFtf4A_mc">was</a> 2004’s <em>Lord of the Rings: The Return of the King</em>, but that was a) the third entry in a beloved trilogy of a beloved book series that had long been considered unfilmable, and b) had elves. Neither was true of Cruise’s air-combat masterpiece, which, besides <a href="https://people.com/top-gun-maverick-new-box-office-record-1-year-after-release-japan-tom-cruise-7506090#:~:text='Top%20Gun%3A%20Maverick'%20has,all%20time%20in%20the%20U.S.">pulling in some $1.5 billion at the box office</a>, definitively proved the superiority of sexagenerian human pilots over remote-controlled drones. Instead, the Academy honored the multiversal extravaganza <em>Everything Everywhere All at Once</em>, which means there is now at least one Best Picture-winning film that features a mystical bagel as its central point. (Michelle Yeoh and Ke Huy Quan rocked, though.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QH9QRq">
So congratulations, Academy, Tom Cruise basically gave you back your business, and <a href="https://ftw.usatoday.com/2023/03/tom-cruise-oscars-academy-awards-top-gun-maverick">for the fourth time</a>, you sent him home with nothing. May you be haunted by whatever weird classical music ghost was poltergeisting around Lydia Tár’s palatial Berlin flat. —<em>BW</em>
</p>
<h4 id="RzDqlE">
<strong>The Philadelphia Eagles will win the 2023 </strong><strong>Super Bowl</strong><strong> (25 percent) — WRONG</strong>
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xgtO8K">
Okay, so, I see it says <a href="https://www.nfl.com/news/super-bowl-lvii-averages-audience-of-113-million-viewers-fox-sports#:~:text=The%20Kansas%20City%20Chiefs'%20last,massive%20viewership%20numbers%2C%20as%20well.">here</a> that the Kansas City Chiefs defeated the Philadelphia Eagles 38-35 in Super Bowl LVII in what was apparently the third most watched television program of all time. Weird — despite being a lifelong Eagles fan, I have no memory of this. But if I <em>had</em> watched the game, I would probably point out:
</p>
<ul>
<li id="FDtPYq">
The field was <a href="https://www.cbssports.com/nfl/news/nfl-pinning-blame-on-eagles-chiefs-for-slippery-super-bowl-field-conditions-per-report/#:~:text=The%20man%20known%20as%20%22The,and%20not%20sanding%20it%20enough.">suspiciously slippery</a> in a way that neutralized the Eagles all-world pass rush against Chiefs QB Patrick Mahomes, who is apparently exempt from the laws of physics — and all the NFL could do was <a href="https://www.foxsports.com.au/nfl/superbowl/nfl-super-bowl-2023-rihanna-halftime-show-made-field-worse-kansas-city-vs-philadelphia-eagles-video-surface-grass/news-story/075452741643d591fbb91eefdbcaadc6">blame Rihanna’s halftime show</a>.
</li>
<li id="o0zmiw">
What kind of treatment allowed Mahomes to do plays like <a href="https://www.chiefs.com/video/patrick-mahomes-best-plays-from-his-super-bowl-lvii-mvp-performance-chiefs-vs-ea">this</a> on what was supposedly a very serious ankle sprain, and was it <a href="https://www.youtube.com/watch?v=PL-5pfIstDU">covered by State Farm</a>?
</li>
<li id="KAvYQw">
How does a quarterback like the Eagles’ Jalen Hurts just… <a href="https://www.youtube.com/watch?v=XMalhNDopoA">drop the ball like this</a>? Not dropping the ball is an important part of being a quarterback, given that it is very hard to play offense if you do not, in fact, hold the ball in your hands.
</li>
<li id="IwFAB1">
At halftime of Super Bowl LVII, the Eagles held a 10-point lead, which gave them an <a href="https://www.yardbarker.com/nfl/articles/super_bowl_2023_live_odds_at_halftime_eagles_vs_chiefs/s1_17080_38461967">implied win probability of 82.1 percent</a> — significantly higher, I would point out, than the 25 percent I gave in my prediction. (For what it’s worth, the Eagles also had an <a href="https://atozsports.com/philadelphia/eagles-could-win-much-more-during-snf-clash-with-cowboys/">82.1 percent chance of winning</a> their division this year before playing the Dallas Cowboys on December 10, who then soundly <a href="https://www.nfl.com/news/cowboys-make-statement-with-dominant-win-over-eagles-though-some-questions-still">thrashed them 33-13</a>.)
</li>
<li id="hyPTTK">
And most importantly… HOW DO YOU CALL A HOLDING PENALTY LIKE <a href="https://www.youtube.com/watch?v=dNCBXFpADlo">THIS</a> ON THE KEY PLAY OF THE MOST IMPORTANT SPORTING EVENT IN OUR (well, mine, at least) LIFETIME?
</li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EuT8Bd">
The lesson here is clear: Don’t put probabilities on your dreams. And maybe don’t drop the football. —<em>BW</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4ipoXy">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bRJHZA">
</p></li>
<li><strong>Israel’s horrible year started long before October 7</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/EAvDMC_S4rdq7XOj9CcpmXg11MU=/184x0:7469x5464/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/73006365/1870666557.0.jpg"/>
<figcaption>
An Israeli flag hangs in a destroyed house on December 20, 2023, in Be’eri, Israel. | Maja Hitij/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
One year into Netanyahu’s latest tenure, Israel’s state and society are truly weakened.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NYHFHq">
A year ago today, <a href="https://www.vox.com/23910085/netanyahu-israel-right-hamas-gaza-war-history">Benjamin Netanyahu</a>’s sixth government was inaugurated with a clear majority, ushering in what Israelis hoped would be a new period of stability after more than three years of political turmoil. Reality quickly proved otherwise.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zinBWQ">
Instead, 2023 has been <a href="https://www.vox.com/israel">Israel</a>’s annus horribilis, marked by a series of events that shook the nation to its core.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GwHw0Q">
<a href="https://www.vox.com/world/2023/1/20/23561464/israel-new-right-wing-government-extreme-protests-netanyahu-biden-ben-gvir">In early January</a>, less than a month after the government was formed, Minister of Justice Yariv Levin unveiled a plan to radically reshape the foundations of Israeli democracy and concentrate power in the hands of the executive. Israelis, many of whom perceived the move as a step toward authoritarianism, took to the streets to halt the judicial overhaul, <a href="https://www.vox.com/world-politics/23629744/why-israelis-protesting-netanyahu-far-right-government-judiciary-overhaul">staging some of the largest mass demonstrations</a> Israel has ever seen week after week. In July, as the Knesset (Israel’s parliament) passed the first legislation of the overhaul, concerns over social disintegration intensified.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ySgw3d">
Then came the deadliest day in the country’s history. On October 7, <a href="https://www.vox.com/politics/2023/10/10/23911661/hamas-israel-war-gaza-palestine-explainer">Hamas</a> terrorists infiltrated Israeli territory and killed over 1,200 people, including many civilians. In the immediate aftermath of the massacre, the Israeli state proved incapable of an immediate effective response; it was left to voluntary organizations to evacuate Israelis living next to the <a href="https://www.vox.com/2018/11/20/18080046/gaza-palestine-israel">Gaza</a> border. <a href="https://www.vox.com/2023/10/7/23907683/israel-hamas-war-news-updates-october-2023">The war in Gaza</a> that ensued is still raging, with over 20,000 <a href="https://www.vox.com/palestine">Palestinians</a> killed and <a href="https://www.unrwa.org/resources/reports/unrwa-situation-report-54-situation-gaza-strip-and-west-bank-including-east-Jerusalem">over 85 percent</a> of the population displaced, <a href="https://www.timesofisrael.com/liveblog-december-28-2023/">over 160</a> Israeli soldiers <a href="https://twitter.com/YonahLieberman/status/1736751987163603154?s=20">killed</a>, and no clear path for the Israeli government to deliver on its stated goals. An annus horribilis indeed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ecSvjX">
How has it come to this — so much damage in so little time?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zUL6gt">
As a first attempt at this — focusing on the internal dynamics of Israeli politics, and without assuming an exhaustive answer — three factors are worth highlighting: populism, polarization, and the personalization of politics. The interplay of these three factors proved so dangerous since it simultaneously weakened both Israeli society and Israel’s state capacity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9n4aVr">
High levels of populism among members of the government fueled the judicial overhaul, which intensified internal strife — emboldening Israel’s adversaries. Then, after the <a href="https://www.vox.com/2023/10/7/23907683/israel-hamas-war-news-updates-october-2023">October 7 attack</a>, the government’s inadequate response exposed Israel’s weakened state, a result of populist assaults on public servants in a polarized climate as well as years of political personalization in which loyalty took precedence over professional qualifications in public service appointments.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MRUcrJ">
This was, of course, a uniquely bad year for Israel, worth understanding in its own right. But Israel is far from the only democratic country confronting some combination of populism, polarization, and personalization — and democracies would do well to heed this tragic tale.
</p>
<h3 id="Wlqz1U">
Netanyahu’s coalition entered power with a decidedly populist bent
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LgFk42">
Benjamin Netanyahu returned to the office of the prime minister, a position he had previously held from 1996–1999 and 2009–2021, and within a week, it was clear that populism would be a defining feature of his tenure.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UsaNVH">
On <a href="https://www.haaretz.com/israel-news/2023-01-04/ty-article/.premium/netanyahus-justice-minister-to-present-plans-for-radical-judicial-overhaul/00000185-7dab-d124-abdd-7fbfc0350000">January 4</a>, Levin announced a plan for a judicial overhaul that aimed to dramatically reorganize the basic architecture of Israeli democracy. <a href="https://en.globes.co.il/en/article-levin-unveils-plan-to-reduce-power-of-israels-supreme-court-1001434722">According to Levin</a>, the court “has eroded trust to a dangerous low and has not brought proper governance. People we didn’t choose — decide for us. This is not democracy.” The judicial overhaul was therefore designed to reshape Israel’s delicate system of checks and balances, lifting constraints over the elected branches.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SBQHDP">
The overhaul consisted of multiple measures, including granting the government greater influence in the selection of judges and restricting the court’s ability to strike down legislation. Critics <a href="https://www.haaretz.com/opinion/2022-12-06/ty-article-opinion/.premium/israel-like-orbans-hungary-is-a-frankenstate-in-the-making/00000184-e33a-db06-a9de-ff3e82700000">warned</a> that these measures were designed to collectively form what legal scholar Kim Lane Scheppele termed a “<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/gove.12049">Frankenstate</a>”: a disfigured democracy crafted by a mishmash of legal arrangements adopted from other countries and patched together to ensure maximum power in the hands of the government. Soon, one of the largest mass protest movements in the history of the country emerged with hundreds of thousands of Israelis taking to the streets week after week.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2NeBYU">
But it’s worth noting that this attack on the functioning of Israel’s state was not some aberration in Netanyahu’s government. While much of the <a href="https://www.newyorker.com/magazine/2023/02/27/itamar-ben-gvir-israels-minister-of-chaos">public attention</a> following the formation of the government went to its most radical elements — such as Itamar Ben-Gvir, previously convicted of <a href="https://www.jpost.com/israel/ben-gvir-convicted-of-inciting-to-racism">incitement to racism and supporting a terrorist organization</a> and now appointed as minister of national security — the judicial overhaul was central to the goals of all parts of the new coalition. It was presented not by a minister from a small fringe party, but by Levin, a minister from Netanyahu’s party, the mainstream Israeli right-wing Likud. This, however, should come as no surprise given evidence that the Likud stands out among mainstream right parties for its extreme level of populism.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="96EJ6X">
For populists, politics is a never-ending struggle between the pure, unified people and the corrupt, malicious elites. Populist leaders claim that they, and only they, are the true representatives of the authentic people. Consequently, they perceive constraints on the executive branch — whether in the form of judicial review or public servants who are committed to ethical, professional service — as hurdles to be dismantled.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lop9OG">
Clear examples of this populist script can be found in the rhetoric of elected representatives from the Likud party, commonly framing state institutions — from the military to the <a href="https://www.bloomberg.com/news/articles/2023-02-20/israeli-minister-blasts-latest-rate-hike-calls-for-intervention?embedded-checkout=true">Bank of Israel</a> — as an all-encompassing “deep state” at the service of corrupt elites. Former Minister of Information Galit Distel-Atbaryan <a href="https://twitter.com/GalitDistel/status/1617060890339119105">tweeted</a> that her party “will continue to free Israel from the oppression of the elites.” The minister of transportation, Miri Regev, <a href="https://twitter.com/regev_miri/status/922808188453482496">railed</a> against “an elite that seeks to override the will of the people.” Tali Gottlieb, a member of Parliament, <a href="https://www.ynetnews.com/article/sy7gkzpsh">stated</a> that “the deep state has infiltrated the leadership of the Shin Bet and the IDF.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5luVdx">
New data confirms that extreme populism is a key feature of Israeli politics. <a href="https://www.chesdata.eu/">The Chapel Hill Expert Survey</a> measures the salience of anti-elite and anti-establishment discourse in the public communication of political parties around the world. While imperfect, this is a useful proxy to measure populism comparatively. <a href="https://journals.sagepub.com/doi/10.1177/13540688231218917">Israel was just added to this data set</a>, which allows us to locate Israeli parties next to their counterparts abroad. Such <a href="https://www.journalofdemocracy.org/articles/why-israeli-democracy-is-in-crisis/">comparative analyses</a> show that Likud is populist to the bone. Its levels of populism align more closely with the European populist radical right than with mainstream right parties. For instance, when compared to Germany, the Likud’s level of populism is more similar to the radical right <a href="https://www.vox.com/world-politics/2023/9/6/23859900/germany-far-right-afd-comeback">Alternative for Germany</a> than to the center-right Christian Democrats.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ph2sId">
In fact, the Likud’s populism is in a similar league with that of the right-wing parties pushing for democratic backsliding in Eastern Europe: Fidesz in <a href="https://www.vox.com/policy-and-politics/2018/9/13/17823488/hungary-democracy-authoritarianism-trump">Hungary</a> and PiS (Law and Justice) in <a href="https://www.vox.com/world-politics/2023/10/14/23916000/poland-elections-2023-october-15-democracy-law-and-justice-tusk-opposition-ukraine">Poland</a>. In both countries, democratically elected governments sought to use legal means to hollow out democratic governance. This is the populist textbook of democratic erosion that Likud was following with its judicial overhaul—pushing a plan that, according to <a href="https://www.jpost.com/israel-news/politics-and-diplomacy/article-728405">then-Chief Justice Hayut</a>, would deal a “fatal blow” to Israeli democracy.
</p>
<h3 id="8zoyJM">
Partisan animosity in Israel is reaching a dangerous peak
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gyp4pj">
Populism often fuels a vicious circle of polarization, as <a href="https://journals.sagepub.com/doi/full/10.1177/0002716218818782">explained</a> by political scientists Jennifer McCoy and Murat Somer: “Populist leaders rail against the establishment or the elites, blaming them for the plight of the people […] When opponents reciprocate with derogatory antipopulist language, the polarizing dynamic spirals.” Importantly, this polarization manifests not in policy disagreements but rather in animosity and hostility across party lines. As would be expected, the growing salience of populist discourse in Israeli politics went hand in hand with growing inter-partisan animosity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fz81gW">
Analyses of survey data collected in Israel reveal that by late 2022, partisan animosity had reached record levels. The <a href="https://socsci4.tau.ac.il/mu2/ines/">Israel National Election Surveys</a> allows us to <a href="https://osf.io/3geaj">track changes</a> over time in affective polarization, <a href="https://www.annualreviews.org/doi/abs/10.1146/annurev-polisci-051117-073034">defined</a> as the difference between how much voters like their own party and how much they dislike political opponents. Out-party dislike has increased since Netanyahu took office in 2009, following a decline during most of the previous decade. When Netanyahu reentered the office of prime minister in 2022, affective polarization had reached its highest level since data began to be collected in the early 1990s.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NRuU0i">
While comparable data has not yet been collected since the <a href="https://www.vox.com/policy-and-politics/23357154/2022-midterm-elections-guide">2022 elections</a>, clashes over the judicial overhaul likely deepened partisan divisions. Specifically, concerns over the spillover effects of polarization and the disintegration of military units were voiced throughout the year, with some 10,000 military <a href="https://www.timesofisrael.com/this-is-where-we-draw-the-line-10000-more-reservists-to-stop-volunteering/">reservists threatening to stop volunteering</a> for service if the government persists with the judicial overhaul.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9gvWoy">
These were real blows to Israeli society and its sense of cohesion — which was interpreted by its enemies as an opportunity to strike.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="N2xjXJ">
As reported in <a href="https://www.haaretz.com/israel-news/2023-11-21/ty-article/.premium/israeli-army-warned-netanyahu-iran-hezbollah-hamas-see-opportunity-for-perfect-storm/0000018b-f18c-d36e-a3cb-f1dfa34d0000">Haaretz</a>, a senior intelligence officer warned Netanyahu that clashes over the judicial overhaul are “worsening the damage to Israeli deterrence and increasing the probability of escalation.” Minister of Defense Yoav Gallant warned in March that the internal strife is eroding Israel’s <a href="https://www.vox.com/defense-and-security">national security</a>. In response, <a href="https://www.timesofisrael.com/netanyahu-fires-defense-minister-gallant-for-calling-to-pause-judicial-overhaul/">Netanyahu sought to fire Gallant</a> but <a href="https://www.timesofisrael.com/netanyahu-reinstates-gallant-blames-previous-government-for-current-wave-of-attacks/#:~:text=Facing%20dire%20polls%20and%20growing,to%20overhaul%20the%20judicial%20system.">rescinded</a> the dismissal in the face of mass public outrage. <a href="https://www.timesofisrael.com/gallant-warns-judicial-overhaul-tensions-may-cause-harm-to-national-security/">In July</a>, in a Knesset Foreign Affairs and Defense Committee meeting regarding the implications of the judicial overhaul, Gallant warned that “there is harm to national resilience that may lead to harm to national security” and added that Israel’s enemies “believe, mistakenly, that they have the opportunity to take advantage of what they perceive as a weakness.” Yet the government moved forward with the judicial overhaul. And then came October 7.
</p>
<h3 id="ofwxrJ">
A weakened state is facing a crisis
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kbC8k5">
It has been almost three months since Hamas’s heinous attack that led to a full-scale war with catastrophic devastation in Gaza, and the magnitude of this catastrophe is beyond imagination. What was clear just days after the attack, however, is that <a href="https://www.washingtonpost.com/world/2023/10/24/israel-democracy-protesters-war-aid/">Israeli civil society</a> demonstrated outstanding solidarity. Organizations such as <a href="https://www.washingtonpost.com/world/2023/10/14/israel-brothers-in-arms-gaza-border/">Brothers and Sisters in Arms</a>, which emerged earlier this year to oppose the judicial overhaul, quickly reoriented their efforts to help survivors. They evacuated people trapped in fighting zones and provided them with food and basic amenities; shipped toys for families with kids living close to the border; <a href="https://www.jpost.com/diaspora/article-769870">and more</a>. Such <a href="https://www.nytimes.com/2023/10/13/world/middleeast/israel-volunteer-unity.html">civic awakening</a> in times of crisis is admirable, but it raises the question: Where was the state?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m2h0nz">
In short, it did not have the capacity to rise to the moment.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rHpBmE">
For populists who see themselves as the exclusive representative of the “real” people, civil servants with professional ethics and willingness to question politicians’ decisions can quickly be labeled as a “<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/1467-8500.12561">deep state</a>” that must be dismantled. And in intensely polarized environments, civil servants raising tough questions may easily be accused of serving political opponents. The negative implications of these two factors on state capacity were further compounded by an additional feature of contemporary Israeli politics: personalization of the political system, <a href="https://academic.oup.com/book/27403/chapter/197217597?login=true#318932050">defined as</a> a “process in which the political weight of the individual actor in the political process increases over time, while the centrality of the political group (i.e., political party) declines.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DYKyMm">
As political systems become increasingly personalized, individual leaders amass growing centrality and authority at the expense of collective institutions. In such a system, loyalty to the leader plays an increasingly important role in appointments to positions of power, overshadowing considerations of professional credentials and proven capacities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PDSEqk">
This is what has happened to Israel over the last four decades.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K8cVzv">
Once again, comparative research is helpful: Researchers who compared levels of personalization in 26 established democracies in 2018 located <a href="https://en.idi.org.il/articles/30962">Israel at the top of the list</a>, together with Italy. This comparison is based on multiple indicators, such as decision-making procedures within parties and the ways media coverage centers on leaders rather than parties. <a href="https://www.washingtonpost.com/politics/2021/06/02/israels-left-hates-netanyahu-his-real-problem-is-that-some-right-wingers-hate-him-too/">The centrality of Benjamin Netanyahu</a> in shaping Israeli politics is hard to overstate. Analyses of survey data reveal that <a href="https://www.taylorfrancis.com/chapters/edit/10.4324/9781003267911-6/king-bibi-liron-lavi-naama-rivlin-angert-clareta-treger-tamir-sheafer-israel-waismel-manor-michal-shamir">sentiments toward Netanyahu</a> have become the primary organizing principle in Israeli politics.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wemiG6">
The implications of this extreme personalization for public service were dire as expected. <a href="https://www.globes.co.il/news/article.aspx?did=1001457700">Less than a month before the Hamas attack</a>, public administration scholars Sharon Gilad and Ilana Shpaizman warned of the consequences of this weakening of the public service. Based on <a href="https://www.haaretz.com/israel-news/2023-09-03/ty-article-magazine/.premium/israeli-civil-servants-dilemma-resign-or-resist-the-judicial-coup-from-within/0000018a-5b4e-d845-adfe-fb6efa9f0000">interviews and a focus group</a> with hundreds of civil servants, they documented increased pressure from political appointees and politicians, and skilled civil servants’ intent to leave the public sector. As <a href="https://www.haaretz.com/israel-news/2023-09-03/ty-article-magazine/.premium/israeli-civil-servants-dilemma-resign-or-resist-the-judicial-coup-from-within/0000018a-5b4e-d845-adfe-fb6efa9f0000">Haaretz reported</a>, managers say they are facing difficulties recruiting and retaining qualified employees. Gilad and Shpaizman <a href="https://www.globes.co.il/news/article.aspx?did=1001457700">presciently concluded</a> that the erosion of state capacity presents a significant threat to all Israelis. The magnitude of this threat became painfully evident when Israeli ministries were glaringly incapable of responding to the deadly October 7 attack.
</p>
<h3 id="2DhzQx">
What now?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2WqHHc">
For Israel, 2023 was a year in which decades happened. As the year draws to an end, Israelis are grappling with the repercussions of its unique noxious blend of populism, polarization, and personalization.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="10L79z">
While Israel faces specific security threats, there is a lesson here that extends beyond national borders. A resilient political system is one that fosters competition across the ideological spectrum while steadfastly resisting the allure of those who undermine state capacity in the pursuit of loyalty and in their fight against imagined elites and fifth columns. The threats and vulnerabilities posed by populism, polarization, and personalization crystallize in times of crisis, when an urgent and robust response is needed but the state proves too weak to react effectively.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="syEfQE">
Democracies worldwide would be wise to heed this tragic cautionary tale.
</p></li>
<li><strong>10 actually good things that happened in 2023</strong> -
<figure>
<img alt="An illustration of a rough ocean. “2023” sits on the horizon like the moon. The water within its glow is calmer than the surrounding water." src="https://cdn.vox-cdn.com/thumbor/RgRNDLQZTX6aP0TPN3Y9-1cDlf0=/240x0:1680x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/73003824/LookingBack_2023_PaigeVickers_Vox.0.png"/>
<figcaption>
Paige Vickers/Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
This was a hard year. But these 10 news stories remind us a better future is possible.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JaIWCQ">
I’m not going to lie to you: 2023 was an ugly year. War rages in <a href="https://www.vox.com/politics/2023/12/14/24001352/gaza-ceasefire-united-nations-israel-palestine">Gaza</a>, <a href="https://www.vox.com/russia-invasion-ukraine">Ukraine</a>, and <a href="https://www.vox.com/world-politics/23712710/sudan-war-khartoum-burhan-hemedt-rsf">Sudan</a>, with millions displaced, injured, or dead. On top of global strife, <a href="https://www.vox.com/technology/23746060/ai-generative-fake-images-photoshop-google-microsoft-adobe">AI-fueled misinformation</a> runs rampant, we’re <a href="https://www.vox.com/23969523/climate-change-cop28-paris-1-5-c-uae-2023-record-warm">barreling past climate goals</a>, and <a href="https://www.americanprogress.org/article/a-year-after-the-supreme-court-overturned-roe-v-wade-trends-in-state-abortion-laws-have-emerged/">abortion access dwindles</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VZf4KI">
But when the world is mired in horrible things, it’s important to imagine a better future; without hope, <a href="https://www.vox.com/the-highlight/23622511/climate-doomerism-optimism-progress-environmentalism">new solutions wouldn’t be possible</a>. In 2023, despite everything, there were moments when that hope actualized into meaningful wins.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2okxuJ">
From the <a href="https://www.vox.com/scotus">Supreme Court</a> <a href="https://www.vox.com/future-perfect/23721488/prop-12-scotus-pork-pigs-factory-farming-california-bacon">upholding America’s toughest animal cruelty law</a> to new developments in <a href="https://www.nytimes.com/2023/12/08/health/fda-sickle-cell-crispr.html">curing sickle cell disease</a>, 2023 saw progress across policy and scientific research that will help shape well-being for humans and animals alike for years to come. Here are 10 breakthroughs in 2023 that help remind us that a better future is worth fighting for.<em> —Izzie Ramirez</em>
</p>
<h3 id="ZsXR5u">
The <a href="https://www.vox.com/economy">economy</a> started undoing 40 years of rising inequality
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TjEjGu">
Among the many surprises of the post-pandemic economy was a <a href="https://www.vox.com/2023/11/20/23964535/labor-market-employment-inflation-sentiment-economy-bad-polls">deep reversal </a>in long-running trends of wage inequality. Over the last three years, an unusually tight labor market has undone an <a href="https://www.nber.org/papers/w31010">estimated</a> 38 percent of the wage inequality between poor and wealthy workers that shot up between 1980 and 2019. Researchers dubbed this “<a href="https://bcf.princeton.edu/events/david-autur-on-the-unexpected-compression-competition-at-work-in-the-low-wage-economy/">the unexpected compression</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5leVMs">
Young workers without college degrees benefited the most. That’s especially good news given the <a href="https://www.vox.com/future-perfect/23895909/angus-deaton-anne-case-life-expectancy-united-states-college-graduates-inequality-heart-disease">ongoing debates</a> around “<a href="https://www.vox.com/2020/4/15/21214734/deaths-of-despair-coronavirus-covid-19-angus-deaton-anne-case-americans-deaths">deaths of despair</a>,” where economists are trying to figure out how to counter the rising mortality rates from heart disease and drug overdose among Americans with the least education. The boosted wages were concentrated among workers who changed jobs. Low-wage workers tend to raise their pay faster by switching jobs than by staying put, but the costs of leaving a bad and low-paying job, especially with the relatively weak American safety net, often keep workers in place.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ewtiX1">
Toward the end of 2023, the wage compression looked to be <a href="https://www.atlantafed.org/chcs/wage-growth-tracker">cooling off</a>, but not reversing. To be clear, <a href="https://www.newyorker.com/magazine/2019/09/02/the-rich-cant-get-richer-forever-can-they">inequality remains</a> a defining feature of the American economy, evidenced by calling its reduction an “unexpected” compression. The Biden White House is pushing some ideas that could help solidify these trends, like <a href="https://www.ftc.gov/news-events/news/press-releases/2023/01/ftc-proposes-rule-ban-noncompete-clauses-which-hurt-workers-harm-competition">banning</a> noncompete agreements or <a href="https://www.dol.gov/general/labortaskforce">boosting</a> workers’ bargaining power. With a few <a href="https://www.vox.com/future-perfect/23965898/child-poverty-expanded-child-tax-credit-economy-welfare-phase-ins">structural changes</a> and a bit of luck, 2024 could build on these trends, transforming our expectations so that reducing inequality becomes the norm. <em>—Oshan Jarow</em>
</p>
<h3 id="waYFcm">
After completing phase 3 trials, psychedelic-assisted therapy seeks FDA approval
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Tnd35i">
In September, MAPS Public Benefit Corporation (BPC) — a company developing prescription psychedelics — <a href="https://www.nature.com/articles/s41591-021-01336-3">published positive results</a> from their second phase 3 clinical trial on MDMA-assisted therapy for PTSD. (<a href="https://med.uc.edu/depart/psychiatry/research/clinical-research/crm/trial-phases-1-2-3-defined">Phase 3 trials</a> feature thousands of patients, and are mostly randomized and blinded.) CEO Amy Emerson <a href="https://mapsbcorp.com/news/maps-pbc-announces-publication-of-results-from-confirmatory-phase-3-mapp2-trial-of-mdma-assisted-therapy-for-ptsd-in-nature-medicine/">stated</a> that these results, published in <em>Nature Medicine</em>, were the last hurdle before applying for FDA approval of MDMA-assisted therapy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="728AWh">
For decades, new and effective treatments for mental illnesses like PTSD, depression, and anxiety have been scant. Over the same period, a resurgence in <a href="https://www.vox.com/future-perfect/23721486/ketamine-dmt-lsd-psychedelics-magic-mushrooms-legalization-recreation-psilocybin">clinical research on psychedelics</a> has been amassing <a href="https://www.vox.com/future-perfect/2020/10/9/21506664/psychedelics-mental-health-depression-ptsd-psilocybin-mdma">evidence of their potential</a> for treating precisely these conditions (the potential benefits of psychedelics extend beyond therapy, but that’s<a href="https://www.vox.com/future-perfect/23972716/psychedelics-meaning-science-psychedelic-mushrooms-ketamine-psilocybin-mysticism"> another story</a>).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EhfMJt">
The <a href="https://maps.org/about-maps/">Multidisciplinary Association for Psychedelic Studies</a> (MAPS), the nonprofit that owns MAPS PBC, has been patiently working toward FDA approval of MDMA therapy since its founding in 1986. This most recent randomized study included 104 participants who’ve lived with PTSD for an average of 16 years. Participants were split into a treatment group that received MDMA plus three monthly therapy sessions, and a placebo group that received extended therapy sessions but no MDMA.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vHJAl8">
86.5 percent of the treatment group experienced measurable benefits, and 71.2 percent no longer met the criteria for a PTSD diagnosis. The therapy-only group still experienced significant benefits, but less so: 69 percent recorded clinically significant improvements, with 47.6 percent no longer meeting PTSD criteria.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DkKHMU">
In December, MAPS PBC officially <a href="https://mapsbcorp.com/news/mdma-for-ptsd-fda-submission/">filed its application</a> to the FDA, concluding a nearly 40-year effort. The approval of MDMA-assisted therapy would mark a watershed moment in the world of <a href="https://www.vox.com/mental-health">mental health</a>, and likely pave the way for other psychedelic drugs, like <a href="https://www.sciencedirect.com/topics/neuroscience/psilocybin">psilocybin</a>, to follow. <em>—OJ</em>
</p>
<h3 id="TajQnu">
It’s another year of massive progress in developing and deploying vaccines
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v3VBMD">
This past year saw a wave of progress in vaccines and treatments for malaria (a disease that still kills about <a href="https://www.who.int/news-room/fact-sheets/detail/malaria">half a million</a> people in Africa each year), tuberculosis (that killed 1.3 million people in 2022), and respiratory syncytial virus, or RSV (the <a href="https://academic.oup.com/jid/article/226/Supplement_2/S154/6666009">leading cause</a> of infant hospitalization in the US and the killer of <a href="https://www.newswise.com/articles/respiratory-syncytial-virus-rsv-responsible-for-more-than-100-000-deaths-worldwide-in-children-under-five-in-2019">over 100,000 children worldwide</a> in 2019).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Kx2WPI">
In October 2021, the World Health Organization (WHO) <a href="https://www.who.int/news/item/06-10-2021-who-recommends-groundbreaking-malaria-vaccine-for-children-at-risk">recommended its first-ever malaria vaccine</a>, RTS,S. In July 2023, the WHO, Unicef, and Gavi (a global vaccine alliance) <a href="https://www.gavi.org/news/media-room/18-million-doses-first-ever-malaria-vaccine-allocated-12-african-countries-2023">committed</a> to delivering 18 million doses of RTS,S across 12 African countries over the next two years. Then, this October, <a href="https://www.ox.ac.uk/news/2023-10-02-oxford-r21matrix-m-malaria-vaccine-receives-world-health-organization-recommendation">the WHO recommended</a> a new and improved R21 malaria vaccine with an efficacy of 75 percent that can be maintained with booster shots.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9AiqgT">
On the <a href="https://www.vox.com/future-perfect/2023/12/13/23998414/tuberculosis-vaccine-m71-human-challenge-trial-volunteers-pandemic">tuberculosis</a> front, there hasn’t been a new vaccine in over a century, but a promising option, the M72 vaccine, is <a href="https://www.washingtonpost.com/wellness/2023/06/30/tuberculosis-vaccine-trial-funding-gates/">entering its final phase</a> of clinical trials. And more are in the works. The advent of mRNA vaccines for Covid-19 has inspired<a href="https://www.gatesmri.org/research-priorities/"> similar efforts</a> to develop mRNA vaccines for TB, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ruu6H6">
And in July, the <a href="https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-prevent-rsv-babies-and-toddlers#:~:text=Today%2C%20the%20U.S.%20Food%20and,remain%20vulnerable%20to%20severe%20RSV">FDA approved</a> a new preventative treatment for <a href="https://www.vox.com/future-perfect/23800167/rsv-shot-infants-fda-antibodies-vaccine-flu-health">RSV</a>. The only approved antiviral treatment for RSV before that was a monoclonal antibody <a href="https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/103770s5185lbl.pdf">developed in 1998</a> called palivizumab, a monthly treatment that was expensive, approved only for certain at-risk infants, and reduced <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516669/">infant hospitalizations</a> by about 58 percent. The new treatment, Beyfortus, offers a number of upgrades. It’s approved for all infants up to 24 months, not just those at high risk. Its efficacy in reducing not just hospitalizations but all doctors’ visits is <a href="https://www.physiciansweekly.com/fda-approves-new-drug-to-protect-against-rsv-in-infants/">up to 70 percent</a> as compared to placebo. And immunity lasts five months, enough to cover the full RSV fall season. As with the others, <a href="https://www.vox.com/science-and-health/23424379/rsv-cold-virus-vaccines-monoclonal-antibodies-flu-covid-maternal-babies-infants-older-adults">more promising treatments</a> are already in the works. —OJ
</p>
<h3 id="4KmDfy">
Mexico decriminalizes abortion
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XjTwoF">
Latin America’s abortion rights movement — colloquially called the “Green Wave” after the <a href="https://www.npr.org/2022/06/27/1107717283/abortion-rights-green-symbol">verdant scarves Argentine activists wore</a> in the late 2010s — <a href="https://www.vox.com/world-politics/2023/9/7/23863267/mexico-abortion-decriminalize-supreme-court-ruling">notched another win this year</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g1qriE">
In September, Mexico’s Supreme Court <a href="https://apnews.com/article/mexico-abortion-decriminalize-d87f6edbdf68c2e6c8f5700b3afd15de">eliminated all criminal penalties at the federal level</a> for people seeking abortions. The ruling will require all federal health institutions to offer abortion to anyone who requests it. As my colleague <a href="https://www.vox.com/world-politics/2023/9/7/23863267/mexico-abortion-decriminalize-supreme-court-ruling">Nicole Narea explains</a>, states will have to change their laws to comply, new clinical standards and guidelines will have to be rolled out, and the public will have to be educated on their newfound right to an abortion and how they can access it. It’s a big shift, one that will have cascading effects for years to come.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qVpwJo">
Mexico’s decriminalization of abortion fits in a wider discussion around <a href="https://www.ibanet.org/latin-america-femicide-legislation#:~:text=In%20Honduras%20the%20rate%20in,reported%20rates%20greater%20than%20one.">femicide and women’s rights</a> across all of Latin America. Thanks to the Green Wave stemming from the <a href="https://wafmag.org/2021/03/the-contribution-of-ni-una-menos-was-to-massify-feminism-says-florencia-alcaraz-ni-una-menos-founding-member/">2015 Ni Una Menos (Not One Woman Less) protests</a>, Argentine lawmakers voted to legalize the procedure in 2020, <a href="https://www.cfr.org/in-brief/what-colombias-legalization-abortion-means-latin-america">Colombia</a>’s highest court decriminalized abortion in 2022, and Ecuadorian lawmakers made abortion legal <a href="https://www.theguardian.com/world/2022/feb/17/ecuador-abortion-rape-cases-legal">in cases of rape</a> in 2022. There’s still progress to be made, but considering the <a href="https://www.vox.com/abortion">US backslide</a>, Mexico’s shift comes <a href="https://www.motherjones.com/politics/2023/11/mexico-has-become-a-haven-for-americans-seeking-an-abortion/">at an opportune time</a>. <em>—IR</em>
</p>
<h3 id="kL9vAa">
Bangladesh gets the lead out of turmeric
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9QpV3I">
We all know lead isn’t good for you, but its true deadliness can often be overlooked. Lead poisoning contributes to as many <a href="https://www.vox.com/future-perfect/2023/9/14/23868347/lead-poisoning-death-toll-world-bank-pure-earth">as 5.5 million premature deaths a year</a> — more than HIV, malaria, and car accidents combined.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0NR2uc">
In poorer countries, lead remains <a href="https://www.vox.com/future-perfect/22834666/lead-exposure-poisoning-developing-countries">ever-present</a>, but Bangladesh <a href="https://www.vox.com/future-perfect/2023/9/20/23881981/bangladesh-tumeric-lead-poisoning-contamination-public-health">has a story of success</a> where scientists, advocates, and government officials worked together to lower lead exposure levels.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GGI5WO">
Despite phasing out leaded gasoline in the 1990s, high blood lead levels continued to be a problem in Bangladesh. When researchers Stephen Luby and Jenny Forsyth tried to isolate the source in 2019, it turned out to be a surprising one: turmeric, a spice commonly used for cooking, was frequently <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705119/">adulterated with lead</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7CE7GA">
With this in mind, the Bangladeshi government and other stakeholders launched an education campaign to warn people about the dangers of lead. Once producers had been warned that lead adulteration was illegal, the government’s Food Safety Authority followed up with raids and fines to those who were caught.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gMrj2G">
<a href="https://www.sciencedirect.com/science/article/pii/S0013935123011325?via%3Dihub">A 2023 paper</a> found that these efforts appear to have eliminated lead contamination in turmeric outright in Bangladesh. “The proportion of market turmeric samples containing detectable lead decreased from 47 percent pre-intervention in 2019 to 0 percent in 2021,” the study found. And blood lead levels dropped in the affected populations, too.<em> —IR</em>
</p>
<h3 id="YwX6h2">
The Supreme Court upheld America’s strongest <a href="https://www.vox.com/animal-welfare">animal welfare</a> law
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DdATjJ">
In 2018, Californians voted to pass <a href="https://www.vox.com/future-perfect/23745935/proposition-12-pigs-pork-california-eggs-veal-hens">Proposition 12</a>, a law requiring that much of the eggs, pork, and veal sold in the state come from animals given more space on factory farms — essentially cage-free conditions. The change is incremental, as cage-free farming is still <a href="https://www.vox.com/future-perfect/23721488/prop-12-scotus-pork-pigs-factory-farming-california-bacon">pretty terrible</a> for the animals, but it represents progress on a massive scale: Californians buy about 12 percent of the US meat and egg supply. (Disclosure: From 2012 to 2017, I worked at the Humane Society of the United States, which led the effort to pass Prop 12.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ejCcVa">
It was the biggest legislative victory yet for the farm animal welfare movement, reducing the suffering of more animals than any other US law. But this year, the Supreme Court came close to striking it down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cXA4Y1">
After Prop 12 passed in 2018, pork producers sued the state to repeal the part that covers pork. The case went all the way to the Supreme Court, and I anticipated the business-friendly conservative majority would side with the pork producers. They didn’t. The court upheld Prop 12 in a 5-4 decision.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DNJd6x">
The vote guarantees that the <a href="https://farmanimalwelfare.substack.com/p/a-big-supreme-court-win-for-farm">700,000</a> or so breeding pigs raised for California’s pork supply won’t be confined in cages so small they can’t even turn around in a circle for virtually their entire lives. It also protects a number of similar laws animal advocates have helped pass since the early 2000s, ensuring millions of animals don’t go back into cages. —<em>Kenny Torrella</em>
</p>
<h3 id="83Gwet">
You can now buy slaughter-free meat
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nFNULZ">
Almost a century ago, <a href="https://new-harvest.org/winston-churchill-prediction/">Winston Churchill</a> predicted that eventually humans would grow meat directly from animal cells, rather than raising animals on farms. It wasn’t until 2015 that a company, Upside Foods, was launched to give it a shot.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LYu6Ol">
This summer, eight years after its founding, the startup sold its first “cell-cultivated” product — chicken grown from animal cells, no slaughter required — at an upscale restaurant in San Francisco, after the US Department of Agriculture gave <a href="https://www.vox.com/future-perfect/23768224/eat-just-good-meat-upside-cell-cultivated-chicken-lab-grown">final approval</a>. Another startup, GOOD Meat, gained final regulatory approval on the same day and is selling its cell-cultivated chicken at a <a href="https://www.vox.com/future-perfect/23801730/cell-cultivated-lab-grown-meat-jose-andres-upside-eat-just">José Andrés restaurant</a> in Washington, DC.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="25vqNA">
Each company is serving up very limited quantities of meat, so it’s nowhere near coming close to displacing conventional meat. The two startups, and the other <a href="https://gfi.org/wp-content/uploads/2023/01/2022-Cultivated-Meat-State-of-the-Industry-Report-2-1.pdf">150</a> or so cell-cultivated meat companies around the world, have a <a href="https://www.vox.com/future-perfect/23980010/cellular-agriculture-consortiums-collaboration-alternative-meat-lab-grown">long way to go to scale up their technology</a> and bring prices down to compete with farmed meat. It’s far from certain they’ll ever get there. But it’s promising that, in under a decade, the nascent field has made major technological and political strides in the attempt to transform the inefficient, inhumane, and unsustainable factory farming system. —<em>KT</em>
</p>
<h3 id="J4SmIh">
Governments around the world are investing in a meat-free future
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DthdZq">
Animal farming accounts for around <a href="https://www.vox.com/future-perfect/23738600/un-fao-meat-dairy-livestock-emissions-methane-climate-change">15 to 20 percent</a> of global greenhouse gas emissions, yet governments have invested only about <a href="https://www.vox.com/future-perfect/23849473/cell-cultivated-meat-impossible-beyond-alternatives-vegan-investment-report-infrastructure">$1 billion</a> since 2020 in developing meat alternatives, and very few policymakers have proposed initiatives to help humanity cut back on its meat consumption. By comparison, governments have invested <a href="https://www.iea.org/news/global-government-spending-on-clean-energy-transitions-rises-to-usd-1-2-trillion-since-the-start-of-the-pandemic-spurred-by-energy-security-concerns">$1.2 trillion</a> since 2020 to scale up clean energy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PcOLJe">
The lack of attention to making food production more sustainable is starting to change, and some big developments occurred this year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IUy9bQ">
Most notably, the government of Denmark invested <a href="https://foodnationdenmark.com/news/denmark-invests-over-eur-90-million-in-fund-for-development-of-plant-based-foods/">nearly $100 million</a> into a fund to help farmers grow more plant-based foods and companies develop meat- and dairy-alternative products. It also launched the world’s first <a href="https://www.foodnavigator.com/Article/2023/10/23/denmark-unveils-the-world-s-first-action-plan-for-plant-based-foods">“action plan”</a> to guide new plant-based food initiatives, like training chefs to cook plant-based meals, reforming agricultural subsidies, and increasing exports of Danish plant-based food products. South Korea <a href="http://koreabizwire.com/south-korea-unveils-ambitious-plan-to-cultivate-thriving-plant-based-food-industry/262752">announced a similar plan</a> this year too, while German policymakers are putting <a href="https://www.foodnavigator.com/Article/2023/11/20/german-government-to-boost-alternative-proteins-with-38m-investment">38 million Euros</a> toward building up the country’s plant-based industry sector and helping farmers transition to growing plant-based foods amid falling meat production and consumption.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t8kXCO">
Canada announced a renewal of <a href="https://www.proteinindustriescanada.ca/news-releases/protein-industries-canada-receives-federal-funding-for-another-five-years">$110 million</a> into its multi-year program for plant-based food R&amp;D and investments in plant-based companies, while <a href="https://www.foodingredientsfirst.com/news/catalonia-boosts-plant-based-production-and-fermentation-made-food-with-%E2%82%AC7m-investment.html">Catalonia</a>, <a href="https://www.foodnavigator.com/Article/2023/09/01/alternative-protein-research-hub-to-be-opened-in-uk">the UK</a>, and <a href="https://www.eurekanetwork.org/open-calls/network-projects-food-tech-alternative-proteins">other countries</a> also put down money this year to develop alternative proteins.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eZoqSd">
Much more is needed, and fast, but increasingly, policymakers are grasping the necessity of transforming food systems in order to meet critical climate goals. <em>—KT </em>
</p>
<h3 id="U3Duxw">
Europe is quickly phasing out the ugly practice of “male chick culling”
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pj7X9r">
Each year, the global egg industry hatches <a href="https://www.vox.com/future-perfect/2023/5/1/23700952/egg-industry-male-chick-culling-animal-welfare">6.5 billion male chicks</a>, but because they can’t lay eggs and they don’t grow big or fast enough to be efficiently raised for meat, they’re economically useless to the industry. So they’re killed hours after hatching, and in horrifying ways: ground up or burned alive, gassed with carbon dioxide, or suffocated in trash bags.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZLd3wu">
In the last five years, however, scientists have begun to commercialize technologies to identify the sex of a chick while still in the egg, enabling egg hatcheries to destroy the eggs before the males hatch. The first machine came online in Europe in <a href="https://www.telegraph.co.uk/news/2018/12/22/ethical-respeggt-eggs-could-save-billions-male-chicks-slaughter/">2018</a>, and the technology is now being adopted by European egg companies at a rapid pace.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Qg7Y2J">
According to the animal welfare organization Innovate Animal Ag, at the end of September 2023, <a href="https://agfundernews.com/in-ovo-sexing-reaches-15-penetration-in-eu-as-tech-to-end-male-chick-culling-advances">15 percent</a> — or 56 million — of Europe’s 389 million egg-laying hens came from hatcheries that use this technology. That percentage is expected to further rise in the years ahead as several more egg-scanning machines will come online soon.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i40CE2">
In the realm of animal farming, technology is often deployed in ways that hurt animals, like <a href="https://www.vox.com/future-perfect/21437054/chickens-factory-farming-animal-cruelty-welfare">breeding</a> them to grow bigger and faster while sacrificing their health and welfare. But here, it’s used to end one of the industry’s cruelest practices. I hope we’ll see even more technologies used for good in the food and farming sectors in the years ahead. —<em>KT</em>
</p>
<h3 id="DIkwXD">
The FDA has approved the first-ever gene editing treatment for use in humans, offering a cure for sickle cell disease
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2ltfmQ">
In December, the Food and Drug Administration <a href="https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapies-treat-patients-sickle-cell-disease">approved</a> the first-ever therapy using CRISPR gene editing technology for patients 12 and older, offering a potential cure for sickle cell disease (SCD). The disease affects 100,000 people in the US and <a href="https://www.thelancet.com/cms/10.1016/S2352-3026(23)00118-7/attachment/1786eec7-aa32-4b06-9a9e-3df7f1f1d707/mmc1.pdf#page=68">millions</a> more abroad. Prior to the approval, the only cure for SCD was a bone marrow transplant, a procedure that requires a compatible donor, and <a href="https://ashpublications.org/bloodadvances/article/5/18/3668/476988/American-Society-of-Hematology-2021-guidelines-for">kills 5 to 20 percent</a> of patients.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M7DiRI">
SCD is a collection of inherited blood disorders where a mutation in hemoglobin, a protein found in red blood cells, shapes them into crescents (”sickles”) that restrict blood flow and limit oxygen delivery across the body’s tissues, causing severe pain and organ damage.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hEfO5G">
The new therapy, under the brand name Casgevy, uses CRISPR like a molecular pair of scissors. It edits a specific portion of a patient’s DNA to make bone marrow cells produce more fetal hemoglobin, which boosts oxygen delivery. In clinical trials, <a href="https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapies-treat-patients-sickle-cell-disease">29 of 31 patients</a> who received treatment were cured of the events that cause pain and organ damage. A second therapy was also approved, Lyfgenia, which adds to a patient’s DNA the functional hemoglobin genes that are resistant to sickling.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ot6vBZ">
As with many novel therapies that rely on frontier technology, the treatment will be expensive, time-consuming, and unavailable to the majority of those in need. At least at first. Roughly three-quarters of those living with sickle cell disease are <a href="https://www.nytimes.com/2023/12/08/health/casgevy-lyfgenia-sickle-cell-africa.html">concentrated in sub-Saharan Africa</a>. And with price tags of <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0000875320/000087532023000054/vrtx-20231208.htm">$2.2 million</a> for Casgevy and <a href="https://investor.bluebirdbio.com/news-releases/news-release-details/bluebird-bio-details-plans-commercial-launch-lyfgeniatm-gene">$3.1 million</a> for Lyfgenia, they remain a pipe dream for most (though racking up payments across a lifetime of SCD is also expensive, <a href="https://www.nytimes.com/2023/12/08/health/fda-sickle-cell-crispr.html">averaging</a> about $1.7 million for those with insurance).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eZmtER">
Still, the news of a cure is providing hope to millions who live with severe chronic pain, and the question of how to expand accessibility is already at the forefront of many <a href="https://www.nbcnews.com/health/health-news/fda-approves-cure-sickle-cell-disease-first-treatment-use-gene-editing-rcna127979">doctors’ minds</a>. Clearing the major hurdle of getting the first-ever gene editing therapy approved for use in humans will allow experts to turn their attention to the question of how to make the treatment available for the millions of people with SCD whose lives could be dramatically improved by it. <em>—OJ</em>
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India in South Africa: India penalised for slow over-rate</strong> - The loss of the two points has worsened India’s standing for the World Test Championship</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IND vs SA second Test | Ravindra Jadeja likely to be available for Cape Town Test</strong> - Jadeja who bowled a few balls during the break on day 3 of the first Test, should be available for selection for the Cape Town which India needs to win to square the two-match series</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IND vs SA | Dean Elgar named South Africa captain for farewell Test against India</strong> - Bavuma has been ruled out of the final Test of the series against India, Cricket South Africa (CSA) said after the conclusion of the first game in Centurion</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IND vs SA | Prasidh Krishna’s performance hints at bare bench strength</strong> - Ishant and Umesh are unofficially done with their Test careers and Shami is nearer to end rather than start.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AUS vs PAK | Cummins the hero as Australia beats Pakistan to clinch series</strong> - Set 317 for victory, Pakistan put up a stellar fight as they chased their first Test triumph in Australia since 1995. But they were dismissed for 237.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>President Droupadi Murmu gives assent to Bill for appointment of CEC, ECs</strong> - The Bill also has provisions for a Selection Committee, chaired by the Prime Minister, leader of the Opposition and a Union minister, to make recommendations to the President for appointment of CEC and other ECs.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CPI(M) in Kerala says Congress’s ambivalence about attending Ayodhya Ram temple consecration will subvert secular ideal of INDIA bloc</strong> - CPI(M) Kerala secretary M.V. Govindan says Congress’s backsliding on secularism, the party’s apologetic defence of Hindutva agenda and failure to yoke regional and democratic forces to INDIA bloc opened the door for BJP to win in Assembly elections in Rajasthan, Chhattisgarh and Madhya Pradesh</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Doctors seek another revision of the NEET SS cut-off, mop-up round to fill vacant seats in super speciality courses</strong> - There are significant vacancies in DM, MCH, DrNB seats even after two rounds of NEET SS counselling, says a doctors association, in a letter to the Health Ministry</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Centre, Assam government sign peace pact with pro-talks faction of ULFA</strong> - The other faction led by Paresh Baruah known as ULFA-I has not joined the peace process. Mr. Baruah is said to be in Myanmar.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Uddhav Thackeray-led Sena (UBT) remains firm on contesting 23 Lok Sabha seats</strong> - Sanjay Raut scorns suggestions of vote-bank disintegration following the Shiv Sen’a split last year</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Wave of Russian air strikes reported across Ukraine</strong> - The attacks appear to have been far-reaching, hitting Kharkiv in the east and Lviv in the far west.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Three ways the conflict could go in 2024</strong> - We asked three military analysts how they think events may unfold in the coming 12 months.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Françoise Bettencourt Meyer: L’Oréal heiress first woman to amass $100bn fortune</strong> - The French beauty empire is on track for its best stock market performance in decades.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sushi with Schumacher: Ex-F1 chef on catering for sport’s big names</strong> - Former chef Dave Freeman recalls his time catering for some of the biggest names on the track.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biarritz: Michelin chef quits after alleged initiation incident</strong> - A kitchen hand was reportedly tied up naked at France’s luxury Hôtel du Palais in Biarritz.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A forensic artist has given a 500-year-old Inca “ice maiden” a face</strong> - Dubbed “Juanita,” the young woman was likely killed during a sacrificial ritual. - <a href="https://arstechnica.com/?p=1992837">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FDA would like to stop finding Viagra in supplements sold on Amazon</strong> - “Big Guys Male Energy Supplement” turns out to be a vehicle for prescription drugs. - <a href="https://arstechnica.com/?p=1992986">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>40% of US electricity is now emissions-free</strong> - Good news as natural gas, coal, and solar see the biggest changes. - <a href="https://arstechnica.com/?p=1992977">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Daily range isn’t a problem with the 2024 Mitsubishi Outlander PHEV</strong> - Charge it every night and you may only ever run the engine on road trips. - <a href="https://arstechnica.com/?p=1992961">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google agrees to settle Chrome incognito mode class action lawsuit</strong> - 2020 lawsuit accused Google of tracking incognito activity, tying it to users’ profiles. - <a href="https://arstechnica.com/?p=1992954">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bob found out he was about to inherit $2 billion</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Bob found out he was going to become a billionaire once his sick father dies. His father had taken every measure to hide his wealth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After finding this out, he decided he needed a woman to enjoy his fortune with.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
So he went to a singles bar where he spotted the most beautiful woman he had ever laid eyes on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Her natural beauty took his breath away. “I may look like just an ordinary dude,” he said as he walked up to her, “but in just a week or two my father will die, and I’ll inherit over 2 billion dollars.”
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Impressed, the woman went home with him that evening. Three days later, he spotted her at his dad’s house. She greeted him with a huge smile and exclaimed, “Bob, I am your new step mother!”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/iluvreddit"> /u/iluvreddit </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/18t5ktg/bob_found_out_he_was_about_to_inherit_2_billion/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/18t5ktg/bob_found_out_he_was_about_to_inherit_2_billion/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A dead man is climbing the stairs of heaven</strong> - <!-- SC_OFF --></p>
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He stops by a gate and sees a beautiful woman who asks him “Do you want to come with me or do you want to succeed?”. The man is tempted, but he decides to continue climbing.
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After a while he comes to another gate where there is now two beautiful women who ask him “Do you want us to take care of you forever or do you want to succeed?”. The man resists again, and continues climbing.
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He stumbles upon yet another gate, where this time he encounters five of the most beautiful women he has ever seen. They tell him “You can come with us and we will satisfy all of your deepest fantasies, or you can decide to continue if you want to succeed”. The man stops for a bit, thinks it through, but manages to resist again and continues climbing the stairway.
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Finally, he comes to the final gate of the stairway and this time encounters a fat, sweaty, naked, old man with a giant dong.
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“Hello? Are you God?” the man asks. “Nope,” the old man replies “I am Seed.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/ficklemick"> /u/ficklemick </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/18tk6u3/a_dead_man_is_climbing_the_stairs_of_heaven/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/18tk6u3/a_dead_man_is_climbing_the_stairs_of_heaven/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The pond</strong> - <!-- SC_OFF --></p>
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An elderly man in Florida had owned a large farm for many years. He had a large pond in the back.
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It was properly shaped for swimming, so he fixed it up nice with picnic tables, horseshoe courts, and some orange, and lime trees. One evening the old farmer decided to go down to the pond, as he hadn’t been there for a while, and look it over.
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He grabbed a five-gallon bucket to bring back some fruit. As he neared the pond, he heard voices shouting and laughing with glee.
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As he came closer, he saw it was a bunch of young women skinny-dipping in his pond.
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He made the women aware of his presence and they all went to the deep end.
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One of the women shouted to him, ‘we are not coming out until you leave!’
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The old man frowned, ‘I didn’t come down here to watch you ladies swim naked or make you get out of the pond naked..’
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Holding the bucket up he said, ‘I’m here to feed the alligator.’
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Some old men can still think fast…
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Northof_49"> /u/Northof_49 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/18t4oxk/the_pond/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/18t4oxk/the_pond/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>God summons Adam and Eve</strong> - <!-- SC_OFF --></p>
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and says to them, “hey guys, I’ve got some more features to divvy up. Who wants extra muscles?”
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“I do!” shouts Adam before Eve can say anything.
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“OK”, says God, “how about extra height?”
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“Mine!” Says Adam, “It goes well with my extra muscles.”
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“And, how about extra body hair?” Asks God.
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“Yoink!” Says Adam, snatching the hair from God before he can finish his sentence. God and Eve share a look. Adam says, “see ya suckers,” as he struts off in his tall, well muscled, hairy body.
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“Well,” sighs God to Eve, “all I have left is multiple orgasms.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/-im-your-huckleberry"> /u/-im-your-huckleberry </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/18syfyu/god_summons_adam_and_eve/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/18syfyu/god_summons_adam_and_eve/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A woman goes to her gynecologist…</strong> - <!-- SC_OFF --></p>
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During the appointment, the gynecologist tells her “you need to stop masturbating.” She asks why and the gynecologist says “because I’m trying to examine you”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Bootlebat"> /u/Bootlebat </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/18t8ank/a_woman_goes_to_her_gynecologist/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/18t8ank/a_woman_goes_to_her_gynecologist/">[comments]</a></span></p></li>
</ul>
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