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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>The Welfare State and Risk Perceptions: The Novel Coronavirus Pandemic and Public Concern in 70 Countries</strong> -
<div>
The novel coronavirus pandemic led individuals to experience heightened social risks, particularly financial and health related. The strength of a welfare state shapes individual risk perceptions under normal circumstances. My research question is whether it also shapes risk perceptions in abnormal disaster scenarios, for example amidst the SARS-CoV-2 pandemic. I test this using the data from the global COVIDiSTRESS survey to compare 70 countries in April of 2020, a month where deaths resulting from Covid-19 affected three-quarters of the world’s societies. Controlling for local timing and severity of the pandemic, welfare state strength predicts lower risk perceptions. However, this it is not a universal effect as I expected. The welfare state impact depends on how quickly a government introduced strong ‘lock down’ measures. The longer it took a government to respond the more the welfare state reduces risk perceptions. Governments that took lock down measures in advance of the virus show no variation in risk perceptions, whereas governments that took 30 days to respond have up to a 1.5 standard deviation range of risk perceptions depending on the strength of the welfare state. I conclude that the welfare state matters very much when governments fail to take effective intervention measures in a global emergency.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/96fd2/" target="_blank">The Welfare State and Risk Perceptions: The Novel Coronavirus Pandemic and Public Concern in 70 Countries</a>
</div></li>
<li><strong>Locked Down or Locked In? Institutionalized Public Preferences and Pandemic Policy Feedback in 32 Countries</strong> -
<div>
The Novel Coronavirus Pandemic provides a unique opportunity to test theories of policy feedback in times of national emergency. An important question in this field is whether the discrepancy between public attitudes and emergency rules makes ordinary citizens less likely to comply, which in turn can undermine the goals of that national emergency policies such as the recent lockdown. In this study, we first compare 2016 institutionalized non-Covid related public preferences for government intervention to government actions taken at the outbreak of this pandemic in early March 2020 across 32 middle to high income countries, using aggregated data from the International Social Survey Program and country-level Blavatnik Coronavirus Government Response Tracker data. Then, we use the relative discrepancy between them to predict public behaviors shortly after the initial outbreak in late-March into early April using the Measuring Worldwide COVID-19 Attitudes and Beliefs survey. We find no association between public preferences and government response at the outbreak; however, we find some tentative evidence that the discrepancy between them shows a relationship with public behaviors in the subsequent stage, after adjusting for the local severity of the outbreak and the current level of government intervention. Where the government took much stronger interventions in the outbreak stage relative to public preferences for non-Covid government interventions, the public were more likely to engage in risky social behaviors, such as going out when asked not to, attending social gatherings, or not keeping a safe distance from others. In contrast, where the government took weaker measures, the public were instead more likely to avoid risky social behaviors. Although we cannot conclude whether this means that the enforced measures were more or less effective, our results may suggest that governments took stronger measures in countries where they expected more risky behaviors and that there may be a tradeoff between institutionalized public preferences and the ability to curtail social behaviours.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/7swqe/" target="_blank">Locked Down or Locked In? Institutionalized Public Preferences and Pandemic Policy Feedback in 32 Countries</a>
</div></li>
<li><strong>Further to the left. Stress-induced increase of spatial pseudoneglect during the COVID-19 lockdown</strong> -
<div>
Background The measures taken to contain the COVID-19 pandemic, such as the lockdown in Italy, do impact psychological health; yet, less is known about their effect on cognitive functioning. The transactional theory of stress predicts reciprocal influences between perceived stress and cognitive performance. However, the effects of a period of stress due to social isolation on spatial cognition and exploration have been little examined. The aim of the present study was to investigate the possible effects and impact of the Covid-19 pandemic on spatial cognition tasks, particularly those concerning spatial exploration, and the physiological leftward bias known as pseudoneglect. A right-hemisphere asymmetry for spatial attention processes crucially contributes to pseudoneglect. Other evidence indicates a predominantly right-hemisphere activity in stressful situations. We also analyzed the effects of lockdown on coping strategies, which typically show an opposite pattern of hemispheric asymmetry, favoring the left hemisphere. If so, then pseudoneglect should increase during the lockdown and be negatively correlated with the efficacy of coping strategies. Methods One week before the start of the lockdown due to Covid-19 in Italy (T1), we had collected data from a battery of behavioral tests including tasks of peri-personal spatial cognition. During the quarantine period, from late April to early May 2020 (T2), we repeated the testing sessions with a subgroup of the same participants (47 right-handed students, mean age = 20, SD = 1.33). At both testing sessions, participants performed digitized neuropsychological tests, including a cancellation task, radial arm maze task and Raven’s advanced progressive matrices. Participants also completed a newly developed COVID-19 Student Stress Scale, based on transactional models of stress, and the COPE-NIV to assess coping orientation. Results The tendency to start cancellation from a left-sided item, to explore first a left-sided arm of the maze, and to choose erroneous response items on the left side of the page on Raven’s matrices, increased from T1 to T2. The degree of pseudoneglect increment positively correlated with perceived stress, and negatively correlated with Positive Attitude and Problem-Solving COPE-NIV subscales. Conclusions Lockdown-related stress may have contributed to increase leftward bias during quarantine through a greater activation of the right hemisphere. On the other hand, pseudoneglect was decreased for better coping participants, perhaps as a consequence of a more balanced hemispheric activity in these individuals.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/xb954/" target="_blank">Further to the left. Stress-induced increase of spatial pseudoneglect during the COVID-19 lockdown</a>
</div></li>
<li><strong>Parents’ intention to vaccinate their children against COVID-19</strong> -
<div>
Usually, parents and caregivers are the ones responsible for children’s vaccination, their intention to vaccinate children depending on many factors. In a society where almost half of adults have refused to take a jab against COVID-19, it is important to know which factors increase or decrease the odds of a child getting vaccinated. In the present study, we examined parents’ reasons for/against children vaccination and predictors of this intention. We found that about 30% of parents intended to have their children vaccinated to protect the health of children and their close ones. On the other hand, parents who did not intend to have their children vaccinated were typically afraid of long-term consequences of vaccination and its side effects, with less than one fifth of them being skeptical about vaccination per se. Using logistic regression analyses, we found that a higher willingness to vaccinate was in male, older parents, and those with higher (socio)economic status. Parents with a higher adherence to restrictions, and higher trust in government and authorities were more likely to vaccinate their children. Moreover, parents who had themselves been vaccinated or were more positive towards vaccination in general were much more willing to vaccinate their children. On the contrary, belief in conspiracy theories decreased this intention 10-times. No other variables (e.g., demographic characteristics, mental health indicators, or direct experience with COVID-19) significantly predicted parents’ intention to vaccinate their children. The study offers several implications related to the complexity of factors which determine hesitant parents’ intention to vaccinate their children. We aimed to answer questions on how, when, and by whom parents should be approached to improve their awareness on vaccination decisions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/58pbg/" target="_blank">Parents’ intention to vaccinate their children against COVID-19</a>
</div></li>
<li><strong>Equity in new active travel infrastructure: a spatial analysis of London’s new Low Traffic Neighbourhoods</strong> -
<div>
NOTE: this is a preprint version of an article since published in the peer-reviewed Journal of Transport Geography. For the final version please visit https://www.sciencedirect.com/science/article/pii/S0966692321002477. In this article we examine equity in new active travel infrastructure in London, UK. We focus on Low Traffic Neighbourhood schemes (LTNs) introduced during Covid-19. These mainly involve ‘modal filters’ that restrict through motor traffic from residential streets. Such approaches to traffic management are traditional in the Netherlands, but relatively new in London and other global cities such as Barcelona. LTNs are often controversial, with one criticism being that they are implemented in affluent areas and hence benefit richer residents. London represents an excellent opportunity to investigate the extent to which these rapidly introduced schemes have so far been equitably distributed. We focused on LTNs introduced between March and September 2020 and still present at the end of October 2020. Having generated datasets representing these new LTN locations and their boundary roads, we matched these to Output Areas (OAs, administrative areas containing around 300 residents). We then examined the extent to which LTN implementation was associated with age, ethnicity, disability, employment and car ownership (Census 2011) and small-area deprivation (Index of Multiple Deprivation 2019). We estimated that 3.7% of all Londoners live inside a new LTN, and 8.8% live within 500m walking distance of a new modal filter. Across London as a whole, people in the most deprived quarter of OAs were 2.7 times more likely to live in a new LTN, compared to Londoners in the least deprived quarter. While overall Black, Asian and Minority Ethnic (BAME) people were slightly more likely than White Londoners to live in a new LTN, this varied by ethnic group. Specifically, Black Londoners were somewhat more likely, and Asian Londoners somewhat less likely than White people to live in a new LTN. Car-free households were more likely to live in a new LTN. Within London’s districts – which lead the implementation of LTNs - there was wide variation, with people in more deprived areas and/or ethnic minorities more likely to live in an LTN in some districts, less likely in others. In the median (‘typical’) district, people in more deprived areas were more likely to live in an LTN than people in less deprived areas, suggesting that, on average, individual districts have prioritised their more deprived areas. However, in the median district, BAME residents were slightly less likely to live in an LTN than White residents. Finally, at the micro level, residents living in LTNs were demographically similar to neighbours living in OAs that touched an LTN boundary road. We conclude that LTN implementation has been broadly equitable at the city level and at the micro level, but not always at the district level. Such metrics should be used in policy and research to monitor and improve the equity of active travel interventions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/q87fu/" target="_blank">Equity in new active travel infrastructure: a spatial analysis of London’s new Low Traffic Neighbourhoods</a>
</div></li>
<li><strong>Breathing and Tilting: Mesoscale simulations illuminate influenza glycoprotein vulnerabilities</strong> -
<div>
Influenza virus has resurfaced recently from inactivity during the early stages of the COVID-19 pandemic, raising serious concerns about the nature and magnitude of future epidemics. The main antigenic targets of influenza virus are two surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). Whereas the structural and dynamical properties of both glycoproteins have been studied previously, the understanding of their plasticity in the whole-virion context is fragmented. Here, we investigate the dynamics of influenza glycoproteins in a crowded protein environment through mesoscale all-atom molecular dynamics simulations of two evolutionary-linked glycosylated influenza A whole-virion models. Our simulations reveal and kinetically characterize three main molecular motions of influenza glycoproteins: NA head tilting, HA ectodomain tilting, and HA head breathing. The flexibility of HA and NA highlights antigenically relevant conformational states, as well as facilitates the characterization of a novel monoclonal antibody, derived from human convalescent plasma, that binds to the underside of the NA head. Our work provides previously unappreciated views on the dynamics of HA and NA, advancing the understanding of their interplay and suggesting possible strategies for the design of future vaccines and antivirals against influenza.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.08.02.502576v1" target="_blank">Breathing and Tilting: Mesoscale simulations illuminate influenza glycoprotein vulnerabilities</a>
</div></li>
<li><strong>A Web-scrapped Skin Image Database of Monkeypox, Chickenpox, Smallpox, Cowpox, and Measles</strong> -
<div>
Monkeypox has emerged as a fast-spreading disease around the world and an outbreak has been reported in 42 countries so far. Although the clinical attributes of Monkeypox are similar to that of Smallpox, skin lesions and rashes caused by Monkeypox often resemble that of other pox types, e.g., Chickenpox and Cowpox. This scenario makes an early diagnosis of Monkeypox challenging for the healthcare professional just by observing the visual appearance of lesions and rashes. The rarity of Monkeypox before the current outbreak further created a knowledge gap among healthcare professionals around the world. To tackle this challenging situation, scientists are taking motivation from the success of supervised machine learning in COVID-19 detection. However, the lack of Monkeypox skin image data is making the bottleneck of using machine learning in Monkeypox detection from skin images of patients. Therefore, in this project, we introduce the Monkeypox Skin Image Dataset (MSID), the largest of its kind so far. We used web-scrapping to collect Monkeypox, Chickenpox, Smallpox, Cowpox and Measles infected skin as well as healthy skin images to build a comprehensive image database and made it publicly available. We believe that our database will facilitate the development of baseline machine learning algorithms for early Monkeypox detection in clinical settings. Our dataset is available in the following Kaggle link: https://www.kaggle.com/datasets/arafathussain/monkeypox-skinimage-dataset-2022.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.08.01.502199v1" target="_blank">A Web-scrapped Skin Image Database of Monkeypox, Chickenpox, Smallpox, Cowpox, and Measles</a>
</div></li>
<li><strong>DNA Origami Presenting the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Response</strong> -
<div>
Effective and safe vaccines are invaluable tools in the arsenal to fight infectious diseases. The rapid spreading of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible of the coronavirus disease 2019 pandemic has highlighted the need to develop methods for rapid and efficient vaccine development. DNA origami nanoparticles (DNA-NPs) presenting multiple antigens in prescribed nanoscale patterns have recently emerged as a safe, efficient, and easily scalable alternative for rational design of vaccines. Here, we are leveraging the unique properties of these DNA-NPs and demonstrate that precisely patterning ten copies of a reconstituted trimer of the receptor binding domain (RBD) of SARS-CoV-2 along with CpG adjuvants on the DNA-NPs is able to elicit a robust protective immunity against SARS-CoV-2 in a mouse model. Our results demonstrate the potential of our DNA-NP-based approach for developing safe and effective nanovaccines against infectious diseases.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.08.02.502186v1" target="_blank">DNA Origami Presenting the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Response</a>
</div></li>
<li><strong>UVC-based air disinfection system for rapid inactivation of SARS-CoV-2 present in the air</strong> -
<div>
The novel coronavirus disease 2019 (COVID-19) infections have rapidly spread throughout the world, and the virus has acquired an ability to spread via aerosols even at long distances. Hand washing, face-masking, and social distancing are the primary preventive measures against infections. With mounting scientific evidence, World Health Organisation (WHO) declared COVID-19 an air-borne disease. This ensued the need to disinfect air to reduce the transmission. Ultraviolet C (UVC) comprising the light radiation of 200-280 nm range is a commonly used method for inactivation of pathogens. The heating, ventilation, and air conditioning (HVAC) systems are not beneficial in closed spaces due to poor or no ability to damage circulating viruses. Therefore, standard infection-prevention practices coupled with a strategy to reduce infectious viral load in air substantially might be helpful in reducing virus transmissibility. In this study, we implemented UV light-based strategies to combat COVID-19 and future pandemics. We tested various disinfection protocols by using UVC-based air purification systems and currently installed such a system in workspaces, rushed out places, hospitals and healthcare facilities for surface, air, and water disinfection. In this study, we designed a prototype device to test the dose of UVC required to inactivate SARS-CoV-2 in aerosols and demonstrate that the radiation rapidly destroys the virus in aerosols. The UVC treatment renders the virus non-infectious due to chemical modification of nucleic acid. We also demonstrate that UVC treatment alters the Spike protein conformation that may further affect the infectivity of the virus. We show by using a mathematical model based on the experimental data that UVC-based air disinfection strategy can substantially reduce the risk of virus transmission. The systematic treatment by UVC of air in closed spaces via ventilation systems could be helpful in reducing the active viral load in the air.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.08.02.502427v1" target="_blank">UVC-based air disinfection system for rapid inactivation of SARS-CoV-2 present in the air</a>
</div></li>
<li><strong>SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta</strong> -
<div>
Since the emergence of SARS-CoV-2, five different variants of concern (VOCs) have been identified: Alpha, Beta, Gamma, Delta, and Omicron. Due to confounding factors in the human population, such as pre-existing immunity, comparing severity of disease caused by different VOCs is challenging. Here, we investigate disease progression in the rhesus macaque model upon inoculation with the Delta, Omicron BA.1, and Omicron BA.2 VOCs. Disease severity in rhesus macaques inoculated with Omicron BA.1 or BA.2 was lower than those inoculated with Delta and resulted in significantly lower viral loads in nasal swabs, bronchial cytology brush samples, and lung tissue in rhesus macaques. Cytokines and chemokines were upregulated in nasosorption samples of Delta animals compared to Omicron BA.1 and BA.2 animals. Overall, these data suggests that in rhesus macaques, Omicron replicates to lower levels than the Delta VOC, resulting in reduced clinical disease.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.08.01.502390v1" target="_blank">SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta</a>
</div></li>
<li><strong>NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids</strong> -
<div>
As SARS-CoV-2 continues to spread worldwide, simple and tractable primary airway cell models that accurately recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model overexpressing the ACE2 receptor that supports robust viral replication while maintaining 3D architecture and cellular diversity of the airway epithelium. ACE2-OE organoids were infected with SARS-CoV-2 variants and subjected to single-cell RNA-sequencing. NF-kB inhibitor alpha was consistently upregulated in infected epithelial cells, and its mRNA expression positively correlated with infection levels. Single-cell imaging showed more IkBa expression in infected cells than uninfected bystander cells, but found concurrent nuclear translocation of NF-kB that IkBa usually prevents. Overexpressing a non-degradable IkBa mutant reduced NF-kB translocation and increased viral infection. These data identify IkBa as a cellular rheostat that controls viral replication by tuning NF-kB. Incomplete NF-kB control in infected cells may promote inflammation and severe disease.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.08.02.502100v1" target="_blank">NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids</a>
</div></li>
<li><strong>Serological surveillance for wild rodent infection with SARS-CoV-2 in Europe</strong> -
<div>
We report serological surveillance for exposure to SARS-CoV-2 in 1,237 wild rodents and other small mammals across Europe. All samples were negative with the exception of one. Given the ongoing circulation of this virus in humans and potential host jumps, we suggest such surveillance be continued.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.08.02.502439v1" target="_blank">Serological surveillance for wild rodent infection with SARS-CoV-2 in Europe</a>
</div></li>
<li><strong>FAITH AND OUTGROUP DEHUMANIZATION DURING COVID: PARADOXICAL ENACTMENT PATTERNS</strong> -
<div>
We investigate religious outgroup dehumanization in American Christians and Buddhists at different levels of intrinsic and extrinsic religiosity to determine how religion and religiosity interact in shielding against existential threat during the pandemic. We find a significant four-way interaction between religion, intrinsic religiosity, extrinsic religiosity, and impact of religious practice due to the Covid-19 pandemic. At higher levels of impact of Covid-19 on religious practice (but not lower levels), Christians high on extrinsic religiosity (but low on intrinsic religiosity) dehumanized religious outgroups the most, whereas Christians high on extrinsic and high on intrinsic religiosity dehumanized religious outgroups significantly less. At low levels of impact of Covid-19 on religious practice, only higher levels of extrinsic religiosity were related to higher levels of dehumanization. Buddhists, regardless of level of religiosity and impact of Covid-19 to religious practice, consistently rated religious outgroups the same. These paradoxical enactment patterns contribute to religion and terror management literature.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/8xuhw/" target="_blank">FAITH AND OUTGROUP DEHUMANIZATION DURING COVID: PARADOXICAL ENACTMENT PATTERNS</a>
</div></li>
<li><strong>Limited induction of lung-resident memory T cell responses against SARS-CoV-2 by mRNA vaccination</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Resident memory T cells (T<sub>RM</sub>) present at the respiratory tract may be essential to enhance early SARS-CoV-2 viral clearance, thus limiting viral infection and disease. While long-term antigen (Ag)-specific T<sub>RM</sub> are detectable beyond 11 months in the lung of convalescent COVID-19 patients after mild and severe infection, it is unknown if mRNA vaccination encoding for the SARS-CoV-2 S-protein can induce this frontline protection. We found that the frequency of CD4<sup>+</sup> T cells secreting interferon (IFN)γ in response to S-peptides was variable but overall similar in the lung of mRNA-vaccinated patients compared to convalescent-infected patients. However, in vaccinated patients, lung responses presented less frequently a T<sub>RM</sub> phenotype compared to convalescent infected individuals and polyfunctional CD107a<sup>+</sup> IFNγ<sup>+</sup> T<sub>RM</sub> were virtually absent. Thus, a robust and broad T<sub>RM</sub> response established in convalescent-infected individuals may be advantageous in limiting disease if the virus is not blocked by initial mechanisms of protection, such as neutralization. Still, mRNA vaccines might induce responses within the lung parenchyma, potentially contributing to the overall disease control.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.25.22275300v2" target="_blank">Limited induction of lung-resident memory T cell responses against SARS-CoV-2 by mRNA vaccination</a>
</div></li>
<li><strong>Measuring various aspects of coronavirus anxiety: A psychometric evaluation of Pandemic anxiety and Coronophobia scales from the latent and network perspective</strong> -
<div>
Background Since the outbreak of COVID-19, understanding and describing the changes in experiences related to the pandemic and its correlates have become crucial. The current study aims to provide a psychometric evaluation and examination of the relationship of two COVID-related anxiety scales through the latent and network approach. Methods The data was collected from the same participants at two time points (Nwave 1 = 1283; Nwave 2 = 1326). The study examined the psychometric properties of the Pandemic Anxiety Scale and Coronaphobia scale. It also examined the factor structure, invariance and relationship with selected variables through both the latent and network approach. Results The PAS and Coronaphobia scale provided good fit and psychometric properties. The results also indicated that distinguishing between them is crucial as they were related differently to various variables. The global network models provided a more complex insight in their connections with the set of selected variables. Conclusion The PAS and Coronaphobia scales are brief and valid measures that can be used in research looking at mental health issues related to the pandemic. The present study shows a unique pattern of relationships of these scales with other variables, extending previous studies into the topic of COVID-related anxiety.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/syweg/" target="_blank">Measuring various aspects of coronavirus anxiety: A psychometric evaluation of Pandemic anxiety and Coronophobia scales from the latent and network perspective</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Puerto Rico COVID-19 Vaccine Uptake Study</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Educational intervention<br/><b>Sponsors</b>:   University of Puerto Rico;   National Institutes of Health (NIH);   National Institute on Minority Health and Health Disparities (NIMHD)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Learn About a New COVID-19 RNA Vaccine Candidate as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Adults</strong> - <b>Conditions</b>:   SARS-CoV-2 Infection;   COVID-19<br/><b>Interventions</b>:   Biological: BNT162b5 Bivalent (WT/OMI BA.2);   Biological: BNT162b2 Bivalent (WT/OMI BA.1)<br/><b>Sponsors</b>:   BioNTech SE;   Pfizer<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Monitoring the Efficacy of a Probiotic Dietary Supplement SmartProbio C in Patients With Severe COVID-19 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: SmartProbio C;   Dietary Supplement: Placebo<br/><b>Sponsors</b>:   Medi Pharma Vision;   Veterinary Research Institute;   Brno University Hospital<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beta-glucans for Hospitalised Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: MC 3x3;   Drug: Placebo<br/><b>Sponsors</b>:   Concentra Educacion e Investigación Biomédica;   Wohlstand Pharmaceutical<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An Observer-blind, Cohort Randomized, Exploratory Phase 3 Study to Evaluate the Safety and Immunogenicity of Recombinant Covid-19 Vaccine, mRNA Covid-19 Vaccine and Recombinant SARS-CoV-2 Trimeric S-protein Subunit Vaccine as 4th Dose in Individuals Primed/ Boosted With Various Regimens</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AstraZeneca/Fiocruz;   Biological: Pfizer/Wyeth;   Biological: Clover SCB-2019<br/><b>Sponsors</b>:   D’Or Institute for Research and Education;   Bill and Melinda Gates Foundation;   University of Oxford<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) as a Booster</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 variant Vaccine (Sf9 Cell);   Biological: COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: mRNA COVID-19 vaccine (Moderna);   Biological: Viral Vector COVID-19 vaccine (AstraZeneca)<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Pulmonary Rehabilitation Program on Post Hospitalization Severe COVID- 19 Patients</strong> - <b>Condition</b>:   Post COVID-19 Condition<br/><b>Intervention</b>:   Combination Product: respiratory exercises - incentive spirometer - walking<br/><b>Sponsor</b>:   Fayoum University Hospital<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Physiotherapy in Post COVID-19 Syndrome Patients</strong> - <b>Condition</b>:   Post-COVID-19 Syndrome<br/><b>Interventions</b>:   Other: Cognitive behavioral principles-based treatment program;   Other: Control intervention<br/><b>Sponsor</b>:   Universidad de Granada<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rehabilitation for People With Post COVID-19 Syndrome</strong> - <b>Condition</b>:   Post-COVID-19 Syndrome<br/><b>Interventions</b>:   Other: Multidimensional intervention;   Other: Control intervention<br/><b>Sponsor</b>:   Universidad de Granada<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Clinical Trial of Immuno-bridging Between Different Manufacture Scales of Recombinant COVID-19 Vaccine (Sf9 Cell)</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Pneumonia<br/><b>Intervention</b>:   Biological: Recombinant COVID-19 vaccine (Sf9 cell)<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A CHW Intervention to Identify and Decrease Barriers to COVID 19 Testing &amp; Vaccination</strong> - <b>Conditions</b>:   Vaccine Hesitancy;   COVID-19 Testing;   Community Health Workers<br/><b>Intervention</b>:   Behavioral: Community Health Worker led curriculum<br/><b>Sponsors</b>:   Charles Drew University of Medicine and Science;   Los Angeles County Department of Public Health;   National Library of Medicine (NLM)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate Safety and Immunogenicity of COVID-19 Vaccine in Children 6 Months to &lt; 12 Years</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Biological/Vaccine: SARS-CoV-2 rS/Matrix-M1 Adjuvant (Initial Vaccination Period);   Biological: SARS-CoV-2 rS/Matrix-M1 Adjuvant (Open Label Crossover Vaccination period);   Biological: SARS-CoV-2 rS/Matrix-M1 Adjuvant (Booster Vaccination);   Other: Placebo<br/><b>Sponsor</b>:   Novavax<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Passive Antibodies Against COVID-19 With EVUSHELD in Vaccine Non-responsive CLL</strong> - <b>Conditions</b>:   Chronic Lymphocytic Leukemia;   COVID-19<br/><b>Intervention</b>:   Biological: EVUSHELD<br/><b>Sponsors</b>:   Sunnybrook Health Sciences Centre;   AstraZeneca<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lollipop COVID-19 Testing Study</strong> - <b>Conditions</b>:   COVID-19;   SARS CoV 2 Infection;   COVID-19 Pandemic<br/><b>Intervention</b>:   Diagnostic Test: Lollipop Swab<br/><b>Sponsor</b>:   University of Wisconsin, Madison<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SWITCH ON: Analysing the Immunogenicity of Additional Booster Vaccinations in HCW</strong> - <b>Condition</b>:   Covid-19 Vaccination<br/><b>Interventions</b>:   Drug: Direct boost mRNA;   Drug: Direct boost adeno;   Drug: Post-poned boost mRNA;   Drug: Post-poned boost adeno<br/><b>Sponsors</b>:   Erasmus Medical Center;   ZonMw (Funding organisation, The Hague, The Netherlands);   LUMC, University Hospital (Leiden, The Netherlands);   UMCG, University Hospital (Groningen, The Netherlands);   AUMC, University Hospital (Amsterdam, The Netherlands)<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variants</strong> - The frequently emerging SARS-CoV-2 variants have weakened the effectiveness of existing COVID-19 vaccines and neutralizing antibody therapy. Nevertheless, the infections of SARS-CoV-2 variants still depend on angiotensin-converting enzyme 2 (ACE2) receptor-mediated cell entry, and thus the soluble human ACE2 (shACE2) is a potential decoy for broadly blocking SARS-CoV-2 variants. In this study, we firstly generated the recombinant AAVrh10-vectored shACE2 constructs, a kind of adeno-associated…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The protective effect of xanthenone against LPS-induced COVID-19 acute respiratory distress syndrome (ARDS) by modulating the ACE2/Ang-1-7 signaling pathway</strong> - OBJECTIVE: Acute respiratory distress syndrome (ARDS) is an inflammatory lung disease that has a high rate of morbidity and mortality. It’s an acute diffusive lung injury caused by the release of pro-inflammatory cytokines into the lungs. Specific microRNAs have been identified to play a crucial role in the renin-angiotensin system signaling pathways the main pathophysiological pathway responsible for ARDS. Since the ARDS life-threatening complication associated with COVID-19 is an ongoing…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of natural RNA modifications on the activity of SARS-CoV-2 RNA-dependent RNA polymerase</strong> - RNA-dependent RNA polymerase (RdRp) plays the key role in replication of RNA viruses, including SARS-CoV-2. Processive RNA synthesis by RdRp is crucial for successful genome replication and expression, especially in the case of very long coronaviral genomes. Here, we analyzed the activity of SARS-CoV-2 RdRp (the nsp12-nsp7-nsp8 complex) on synthetic primer-templates of various structures, including substrates with mismatched primers or template RNA modifications. It has been shown that RdRp…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Porcine Deltacoronavirus Infection Cleaves HDAC2 to Attenuate Its Antiviral Activity</strong> - Protein acetylation plays an important role during virus infection. Thus, it is not surprising that viruses always evolve elaborate mechanisms to regulate the functions of histone deacetylases (HDACs), the essential transcriptional and epigenetic regulators for deacetylation. Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus, causes severe diarrhea in suckling piglets and has the potential to infect humans. In this study, we found that PDCoV infection inhibited cellular…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“Intention to receive COVID-19 vaccine among healthcare workers: a comparison between two surveys”</strong> - CONCLUSIONS: Present study showed an undesirable rate of intention to receive COVID-19 vaccine among healthcare workers, especially decreasing over the time, emphasize the need of interventions to promote healthcare workers’ intention to receive the vaccine and reduce the spread of COVID-19 disease.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients</strong> - Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s and cardiovascular diseases. Although APOE has recently been associated with increased susceptibility to infections of several viruses, whether and how APOE and its isoforms affect SARS-CoV-2 infection remains unclear. Here, we show that serum concentrations of APOE correlate inversely with levels of cytokine/chemokine in 73 COVID-19…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bovine coronavirus nucleocapsid suppresses IFN-β production by inhibiting RIG-I-like receptors pathway in host cells</strong> - The present study aimed to explore if bovine coronavirus nucleocapsid (BCoV N) impacts IFN-β production in the host cells and to reveal further molecular mechanism of BCoV pathogenesis. Human embryonic kidney (HEK) 293 T cells were transiently transfected with pMyc-BCoV-N recombinant plasmids, then infected with the vesicular stomatitis virus (VSV). Expression levels of beta interferon (IFN-β) mRNA were detected using RT-qPCR. The results showed that BCoV N gene was 1347 bp that was consistent…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Human TMPRSS2 non-catalytic ectodomain and SARS-CoV-2 S2’ subunit interaction mediated SARS-CoV-2 endocytosis: a model proposal with virtual screening for potential drug molecules to inhibit this interaction</strong> - This study proposes a novel model for integration of SARS-CoV-2 into host cell via endocytosis as a possible alternative to the prevailing direct fusion model. It is known that the SARS-CoV-2 spike protein undergoes proteolytic cleavage at S1-S2 cleavage site and the cleaved S2 domain is primed by the activated serine protease domain (SPD) of humanTMPRSS2 to become S2’. The activated SPD of TMPRSS2 is formed after it is cleaved by autocatalysis from the membrane bound non-catalytic ectodomain…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ion channel inhibition with amiodarone or verapamil in symptomatic hospitalized nonintensive-care COVID-19 patients: The ReCOVery-SIRIO randomized trial</strong> - CONCLUSIONS: In this randomized trial, neither amiodarone nor verapamil were found to significantly accelerate short-term clinical improvement. Peak CRP and nadir platelet counts were associated with increased mortality both in isolation and by cluster analysis.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Unveiling the “Template-Dependent” Inhibition on the Viral Transcription of SARS-CoV-2</strong> - Remdesivir is one nucleotide analogue prodrug capable to terminate RNA synthesis in SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) by two distinct mechanisms. Although the “delayed chain termination” mechanism has been extensively investigated, the “template-dependent” inhibitory mechanism remains elusive. In this study, we have demonstrated that remdesivir embedded in the template strand seldom directly disrupted the complementary NTP incorporation at the active site. Instead, the translocation…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tackling medical misinformation in allergy and immunology practice</strong> - SummaryWhen Dictionary.com named “misinformation” the word of the year, it stated that “The rampant spread of misinformation poses new challenges for navigating life …”. That was in 2018, two years before the global COVID-19 pandemic fundamentally changed the manner in which misinformation inhibited public health efforts unlike any other time in human history. Our patients are continually seeking information pertaining to their health. When we see them for new patient consultations or follow up…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antimicrobial Alkaloids from Marine-Derived Fungi as Drug Leads versus COVID-19 Infection: A Computational Approach to Explore their Anti-COVID-19 Activity and ADMET Properties</strong> - Therapeutic strategies based upon enzyme inhibition have recently gained higher attention in treating hazardous ailments. Herein, the potential use of seventy-two antimicrobial alkaloids isolated from marine-derived fungi to fight COVID-19 infection via inhibition of SARS-CoV-2 lethal virus was performed using in silico analyses. Molecular modelling was performed to assess their enzyme inhibitory potential on the main protease SARS-CoV-2 M^(Pro), 3-chymotrypsin-like protease SARS-CoV-2…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Access to Health Care for Migrants Along the Mexico-United States Border: Applying a Framework to Assess Barriers to Care in Mexico</strong> - CONCLUSIONS: While Mexico’s health regulations are inclusive of migrants, in practice there are major barriers to access public health services, which might inhibit migrants from seeking those services. In order to comply with its commitment to guarantee the right to health of all persons, the Mexican health authorities should address the implementation gap between an inclusive policy, and the barriers to access that still remain.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approach</strong> - Objective: Nobody knows when the COVID-19 pandemic will end or when and where the next coronavirus will outbreak. Therefore, it is still necessary to develop SARS-CoV-2 inhibitors for different variants or even the new coronavirus. Since SARS-CoV-2 uses its surface spike-protein to recognize hACE2, mediating its entry into cells, ligands that can specifically recognize the spike-protein have the potential to prevent infection. Methods: We have recently discovered DNA aptamers against the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Non-Targeted Metabolomic Analysis of Chicken Kidneys in Response to Coronavirus IBV Infection Under Stress Induced by Dexamethasone</strong> - Stress in poultry can lead to changes in body metabolism and immunity, which can increase susceptibility to infectious diseases. However, knowledge regarding chicken responses to viral infection under stress is limited. Dexamethasone (Dex) is a synthetic glucocorticoid similar to that secreted by animals under stress conditions, and has been widely used to induce stress in chickens. Herein, we established a stress model in 7-day-old chickens injected with Dex to elucidate the effects of stress…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
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<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Upstart Union Challenging Starbucks</strong> - Baristas nationwide are remarkably organized. Is the company’s C.E.O., Howard Schultz, using firings, store closures, and legal delays to thwart them? - <a href="https://www.newyorker.com/news/dispatch/the-upstart-union-challenging-starbucks">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Will the Manchin Deal Finally Kill the “Carried-Interest” Loophole?</strong> - Democrats may be on the verge of forcing private-equity tycoons to pay their fair share in taxes—a step that reformers have been demanding for years. - <a href="https://www.newyorker.com/news/our-columnists/will-the-carried-interest-loophole-finally-die">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Death of Ayman al-Zawahiri</strong> - The Al Qaeda leader was reportedly killed in Afghanistan by a U.S. drone strike. - <a href="https://www.newyorker.com/books/double-take/the-death-of-ayman-al-zawahiri">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The New Fight Over an Old Forest in Atlanta</strong> - The plans for an enormous police-training center—dubbed Cop City by critics—have ignited interest in one of Atlanta’s largest remaining green spaces. - <a href="https://www.newyorker.com/news/letter-from-the-south/the-new-fight-over-an-old-forest-in-atlanta">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ayman al-Zawahiri and the Taliban</strong> - What does the stark evidence of the renewed relationship between Al Qaeda and Afghanistan’s leaders suggest? - <a href="https://www.newyorker.com/news/daily-comment/ayman-al-zawahiri-and-the-taliban">link</a></p></li>
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<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
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<li><strong>Instagram is once again in its flop era</strong> -
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A slew of new changes has drawn the ire of celebrities and regular users alike. But hating Instagram is nothing new.
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For as long as Instagram has existed, <a href="https://www.theguardian.com/technology/2012/jul/19/instagram-debasing-real-photography">people</a> <a href="https://www.pewresearch.org/journalism/2012/04/19/instagram-facebook-and-media-controversies-lead-social-media/">have</a> <a href="https://www.theverge.com/2012/4/9/2928975/instagram-filters-ping-counterping">complained</a> <a href="https://www.theguardian.com/technology/blog/2012/apr/09/facebook-buys-instagram-everyone-hates">about</a> <a href="https://www.cnet.com/tech/tech-industry/instagram-says-it-now-has-the-right-to-sell-your-photos/">it</a>. Hating Instagram — and to an even greater extent its sister site, Facebook — is among the few opinions that a majority of the internet seems to share, but over the past few weeks, the volume has been turned up rather significantly. Last Thursday, Instagram head Adam Mosseri addressed the criticism in a video that, naturally, resulted in even more of it.
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The most recent controversy stems from Instagram’s parent company Meta (previously called Facebook) and its propensity to copy the features of up-and-coming social media platforms. Right now, Instagram’s biggest competitor is <a href="https://www.vox.com/tiktok">TikTok</a>, which serves users an infinite feed of personalized trending short-form video and whose popularity has skyrocketed just as Facebook’s has begun to wane. In an effort to replicate its success, several of the latest Instagram and Facebook updates prioritized “recommended” videos (i.e., from random users across the platform as opposed to someone you already follow), among other things that made people very stressed out. “The new Instagram update really understood what I was looking for: none of my friends’ content, reposted TikToks from meme accounts I do not follow, 100x more ads, everything played at full volume against my will,’’ summarized <a href="https://twitter.com/msmegwatson/status/1547378638831906816?s=10&amp;t=YqABTdQq3OmsMEM6RDiAhg">one viral tweet</a>.
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The furor reached a fever pitch <a href="https://www.instagram.com/p/CgVLB1Dj3Ow/">when a post</a> by photographer Tati Bruening went viral, demanding, “Make Instagram Instagram Again,” and “stop trying to be TikTok, I just want to see cute photos of my friends. Sincerely, everyone.” The post, which now has more than 2 million likes, was reshared by some of Instagram’s most powerful users, namely, Kim Kardashian and Kylie Jenner.
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Concurrently, dozens of meme creators staged a rally outside of Meta’s New York headquarters on July 23 in <a href="https://www.buzzfeednews.com/article/kelseyweekman/instagram-creators-protest-moderation-policy">what they called an “Instarrection.”</a> Though the event was not focused on the new updates and instead protested Instagram’s nebulous, inconsistent moderation practices, which often result in accounts being taken down for unclear reasons, it reflects a growing sentiment among Instagram users that Instagram is getting worse.
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By all accounts, Meta’s shareholders agree. Earlier this year, Meta announced that users were <a href="https://www.wsj.com/articles/meta-platforms-facebook-fb-q4-earnings-report-2021-11643762900?mod=article_inline">spending less time on its platforms</a> and that it expected revenue growth to slow, causing its <a href="https://www.wsj.com/articles/facebook-owner-metas-stock-price-plunges-premarket-jolting-tech-investors-11643887542?mod=article_relatedinline">stocks to plunge 26 percent</a>, losing $232 billion in the process, and becoming the steepest one-day decline for a single stock in US history. The mood, on Instagram and within its headquarters, is bleak: This summer, CEO Mark Zuckerberg has limited spending at the company while <a href="https://www.nytimes.com/2022/07/26/technology/zuckerberg-meta-facebook-earnings.html">pressuring employees to “operate with increased intensity”</a> and threatening to cut low performers. “There are probably a bunch of people at the company who shouldn’t be here,” he told staff.
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Being mad at Instagram is sort of like being mad at the president: Venting your frustrations about it is both a cathartic and logical response to a seemingly insurmountable problem, the problem of too much power in the hands of too few people. In 2019 I wrote about how, within a decade of its existence, <a href="https://www.vox.com/the-goods/2019/12/2/20983760/instagram-removing-likes-authenticity">Instagram broke our brains</a>, training us to view one another as commodifiable brands and splinter ourselves in two. In 2021 I wrote about how visual-first social platforms can make as many changes as they like in response to the knowledge that their products harm users’ self-esteem, but <a href="https://www.vox.com/the-goods/22226997/body-positivity-instagram-tiktok-fatphobia-social-media">they will never solve the problem they created</a>. In 2022 I wrote about how <a href="https://www.vox.com/the-goods/23000352/instagram-algorithm-reels-video-following-favorites">Instagram’s incessant fixation on video</a> ends up worsening the content on the site while also dramatically increasing the workload required to succeed on the platform. Instagram has made <a href="https://www.vox.com/videos/2020/10/28/21538763/save-the-children-qanon-instagram">dangerous misinformation look adorable</a> and <a href="https://www.vox.com/the-goods/2019/7/11/20686194/antelope-canyon-instagram-page-arizona-navajo">beautiful destinations unbearable</a>; it has lied, <a href="https://www.wsj.com/articles/the-facebook-files-11631713039">repeatedly</a>, and yet people feel as though they have nowhere else to go.
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Last week, Instagram caved, slightly, to the growing chorus of criticism. In an interview with tech reporter Casey Newton, <a href="https://www.platformer.news/p/-instagram-walks-back-its-changes">Mosseri said that the app</a> would phase out one of the recent redesigns it had been testing while also temporarily showing users fewer “recommended” videos in the feed. Yet the changes aren’t permanent: By the end of 2023, Zuckerberg said that the number of “recommended” posts on Instagram <a href="https://www.theverge.com/2022/7/27/23281451/facebook-instagram-meta-recommendation-discovery-engine-ai">will more than double</a>. Mosseri attributes this change to a shift in what news feeds are for. “In a world where more of the friend content has gone from feed into stories and DMs, I think that feed is going to become more public in nature,” he said.
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For the average Instagram user, the kind that would never <a href="https://www.vox.com/the-goods/22939754/how-to-become-a-content-creator-economy">describe themselves as a “creator”</a> despite the growing number of people who do, this won’t come as good news. As one venture capitalist put it, <a href="https://www.washingtonpost.com/technology/2022/07/27/instagram-video-shift-kardashian/">speaking to the Washington Post</a>, “There’s a war between people who want Instagram to be more like Snapchat and people who want it to be more TikTok. Right now the former group is larger and louder.”
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The problem is that Instagram doesn’t actually care as much about that group as it does about the other: Instead, Instagram sees the best way to grow a loyal, exceedingly active user base as dangling the prospect of getting famous in front of them. Video, then, is only a means to that end. “I think one of the most important things is that we help new talent find an audience,” Mosseri added. “If we want to be a place where people push culture forward, to help realize the promise of the internet, which was to push power into the hands of more people, I think that we need to get better at that.”
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Curiously, some of the buzziest new social apps as of late — BeReal, NGL, and Locket — have nothing to do with fame at all. On BeReal, <a href="https://www.vox.com/the-goods/23075161/bereal-app-authenticity-posting-self">users see spur-of-the-moment photos</a> from mutual contacts, while Locket allows them to share pictures directly to each other’s home screens. NGL, meanwhile, is an Q&amp;A app that became a popular game on Instagram Stories this June, where those with access to a link could ask anonymous questions of the poster. None of them promise the total digitization of the social circle that Facebook and Instagram do, nor do they offer the possibility of virality.
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Instagram, meanwhile, has decided it should be everything to everyone. As Meta continues its pivot towards the <a href="https://www.gawker.com/tech/the-metaverse-is-for-babies">so-called “metaverse,”</a> an as-yet-mostly-theoretical vision where <a href="https://venturebeat.com/2021/11/21/the-metaverse-will-make-your-meetings-worse/">bitmojis have meetings (?)</a>, it seeks to be even more. What remains in question is whether America’s antitrust laws will actually be enforced to prevent <a href="https://www.vox.com/recode/22933851/meta-facebook-metaverse-antitrust-regulation">Meta from employing the same monopolistic practices there</a>, too, and to what extent Meta can continue to grow its extensive, unprecedented authority over the internet. In all likelihood, however mad everybody is at Facebook and Instagram now, it’s only going to get worse.
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<em>This column was first published in The Goods newsletter. </em><a href="https://www.vox.com/pages/newsletters"><em>Sign up here</em></a><em> so you don’t miss the next one, plus get newsletter exclusives.</em>
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<li><strong>Investing is emotional. Here’s how to navigate.</strong> -
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<img alt="A hand over a pile of money resting inside the jaws of an open bear trap." src="https://cdn.vox-cdn.com/thumbor/XQ3fe5jV0w2A3HdbzaOvx8vP-cI=/119x0:2004x1414/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71203399/GettyImages_1365762701.0.jpg"/>
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The stock market can be an emotional roller coaster. It shouldn’t be. | Getty Images/iStockphoto
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There’s how you think about investment risk — and then how you feel about it.
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Investing can feel very good when things are going well. It can also feel very not good when things are not going well. Case in point: If you were investing (or, let’s be honest here, speculating) in <a href="https://www.vox.com/the-goods/23071245/bitcoin-price-crypto-ethereum-nfts-defi-stablecoin">crypto</a> in the fall of 2021, you probably were much happier with the situation than, say, if you were doing so in the <a href="https://www.vox.com/recode/23158583/crypto-winter-crash-bitcoin-eth-bubble-peter-kafka">summer of 2022</a>.
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<a href="https://www.investopedia.com/articles/basics/10/how-to-avoid-emotional-investing.asp#:~:text=Having%20an%20investment%20plan%20and,easy%20ways%20to%20maintain%20objectivity.">Conventional</a> <a href="https://www.cnbc.com/2022/02/22/how-to-control-your-emotions-during-stock-market-volatility.html">wisdom</a> <a href="https://www.moneycrashers.com/emotion-enemy-investing/">goes</a> that you’re not supposed to factor in emotions at all when you invest, or at least you’re supposed to try to keep your emotions out of them as much as possible. To the extent that’s not possible for you, it’s important to know, too.
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Investing is inherently risky, no matter how supposedly safe or speculative the asset, and not everyone is equipped to handle risk equally. Finding the right risk-reward mix is a tricky balance. There’s also a <a href="https://www.investopedia.com/ask/answers/08/difference-between-risk-tolerance-and-risk-capacity.asp">difference</a> between risk capacity, meaning the risk you should take to meet your financial goals, and risk tolerance, meaning how much risk you can deal with emotionally. You don’t want your retirement account to keep you up at night. You also don’t want to keep your money in cash your whole life and then run out of money once you actually retire because you never invested it.
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“Different people at different times in their lives and with different investments are more able to accept volatility,” said Zach Teutsch, managing partner at Values Added Financial. Experts generally say younger people are better off in riskier investments, such as stocks, because they’re better able to wait out a downturn than someone older and closer to retirement. But there’s more to it than stocks vs. bonds vs. retirement date.
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There is no surefire formula for determining how much risk you can and should take on in investing, and it’s definitely not a one-size-fits-all situation. But as you approach investing — whether you’re already in the market or considering it — it’s absolutely something to keep thinking about.
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“You really need to start having a risk-reward conversation with yourself and be honest with yourself about what your risk tolerance is. You really need to ask yourself, ‘How much am I okay losing?’” said Kristin Myers, editor-in-chief of The Balance, a finance website. She said you also have to think about how much potential opportunity you’re comfortable with losing out on if you’re super risk averse. “I challenge people, when it comes to risk, to really think about the potential and the upside, the opportunity for reward,” she said, “especially if you’re in it for the long term.”
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Here are some ideas on how to think about measuring investing risk in your own life — though to be clear here, neither I nor Vox can provide financial advice. I also want to be clear that we’re largely talking about more traditional investments like the stock market, and not crypto, which can be <a href="https://www.vice.com/en/article/y3v3ny/all-my-apes-gone-nft-theft-victims-beg-for-centralized-saviors">quite </a><a href="https://afkgaming.com/esports/news/axie-inifnitys-ronin-lost-600-million-worth-of-cryptocurrency-to-hackers#:~:text=Axie%20Infinity's%20Ronin%20Lost%20%24600%20Million%20Worth%20of%20Cryptocurrency%20to%20Hackers,-John%20Dave%20Rossel&amp;text=Ronin%20Network%20lost%20173.6K,and%20monitor%20the%20stolen%20funds.">a</a> <a href="https://consumer.ftc.gov/articles/what-know-about-cryptocurrency-and-scams">bit</a> <a href="https://cryptoslate.com/voyager-users-might-not-get-all-their-money/">different</a> risk-wise.
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Figure out your goals and what it will take to achieve them
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When investors are thinking about their risk tolerance in investing, a lot depends on what the investment wealth will be used for, explained Hersh Shefrin, a professor of finance at Santa Clara University’s Leavey School of Business, in an email. Essentially, that means think about your goals. If it’s for retirement, figure out when you’re looking to retire, and what your needs will be when you do. The same advice goes for if you’re investing to pay for a vacation or a new car or education or your kids’ weddings. Ask yourself when you want to pay for something, how much it will cost, and what you’ll need to invest to try to get there. Talk to your partner or anyone you share finances with as well, so that you’re on the same page about what you want to achieve.
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Missing goals can feel like a failure to people, and a failure they’d like to avoid, so it’s important to keep that in mind as well. “Asking how much can I afford to lose is about asking what amount corresponds to failure, either partial or total,” he said. “Tolerance for risk is often tied up with two questions: how important is a goal and how ambitious is the goal? People who set ambitious goals and feel very strongly about achieving those goals will take a lot of risk.”
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<q>“How you feel about something is typically stronger and more difficult to change than how you think about something”</q>
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Once you figure out the goals, then that’s the time to think about the investing plan. I’m not going to tell you what the plan should be, but once you do have one in place, it’s important to recognize that the going at some points could get a little tough. Part of figuring out your risk profile is determining what you want to do if that happens — and do that ahead of time.
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Shefrin said it’s important to have policies in place so that you’re not overcome in the heat of the moment and make a decision you’ll later come to regret. “In cool, calm moments, write yourself a letter laying out a policy of how you will behave in a few different scenarios, so that you are prepared,” he said.
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Have a talk with yourself about your risk tolerance and biases
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One important thing to keep in mind in investing is you do not want to be investing money you absolutely need in the near term. If it’s money that you have to have to pay your rent or buy groceries, it’s best to keep it in cash. Ups and downs are part of the process in the market, and you don’t want to get caught in a down moment in a tough spot.
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Michael Pompian, founder and chief investment officer at Sunpointe Investments and an expert in behavioral finance, said he generally looks at prospective 10-year returns when making investment plans for his clients, and he thinks people should look at least at a five-year horizon, meaning the amount of time you’re able to stick with the investment until you need the money back. “If you need that money in the next year or two, you shouldn’t be investing with risky investments, with stocks,” he said. He has a risk tolerance questionnaire he gives to clients that is, in part, behavioral, asking people if their portfolios go down, how they’ll feel. If you don’t have an adviser — and many people don’t — you can have this conversation with yourself.
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Investors should think of their biases heading in and be aware of them as they proceed. In financial decisions, <a href="https://www.investopedia.com/articles/investing/051613/behavioral-bias-cognitive-vs-emotional-bias-investing.asp">experts generally talk about</a> cognitive biases and emotional biases. Cognitive biases are concepts and beliefs that may or may not be true; emotional biases are more in-the-moment.
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For example, maybe you’re engaged in confirmation bias, where you’re seeking out information that reaffirms what you already think (that a stock is a good or bad pick, say), or you’re dealing with the endowment effect, where you’re putting more value on something you already own than you should. Some investors are overly averse to loss or to risk, or maybe they’re a bit of an adrenaline junkie. Sometimes, investors get caught up believing patterns will just stay as they are, so a bull market will stay a bull and a bear market a bear. Or, when things go poorly, they panic.
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“When you’re talking to someone who’s driven by emotion, numbers often don’t resonate,” Pompian said.
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He said once people think through what their biases are, that’s when they should think about what kind of investor they are — and warned that emotional investors might have a bit more difficulty dealing with ups and downs.
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“How you feel about something is typically stronger and more difficult to change than how you think about something,” Pompian said. “If you tend to get emotional about your investing, that’s where you really want to make sure you’re not taking too much risk.”
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That might also play into what you want to invest in. One of the principles of investing is that the more individualized risk you take — say, by betting on a single stock — the more potential upside but also the more potential losses. It’s important to understand the difference between diversified and concentrated investment and realize which one you’re in.
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People tend to believe that they can time the market and, ultimately, beat it, even though chances really are they can’t. Warren Buffett <a href="https://www.cnbc.com/2018/02/16/warren-buffett-won-2-point-2-million-on-a-bet-and-gave-it-to-girls-inc.html">famously once bet a guy</a> the S&amp;P 500 would beat hedge fund managers over the course of a decade and won. So when thinking about biases, you might also be a little biased toward believing in your own talent.
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“Smart people are used to going through life and realizing that when they apply their intelligence to situations, they achieve better outcomes, and that’s true for a lot of things,” Teutsch said. For example, you learn that if you study for a test, you do better. “But investment is different. All the things smart people have learned throughout their entire life, that they do better than normal people, are not really true with investing.”
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Recognize there are risks in investing — and in sitting it out
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A lot of the time when thinking about risk, you might associate it with people taking on too much uncertainty in a way that loses them money — someone who hopped into crypto or a meme stock hoping it would make them a millionaire and got wiped out. But there’s risk in inaction, too, that’s worth considering.
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Teutsch pointed to the example of money for retirement. If you put your 401(k) in <a href="https://www.schwab.com/etfs/understand-etfs">exchange traded funds</a> (ETFs), meaning funds that track little baskets of assets like stocks, and other investments with a target retirement date, chances are really high that you will have more money by the time that date arrives. (The S&amp;P 500 <a href="https://www.investopedia.com/ask/answers/042415/what-average-annual-return-sp-500.asp">historically</a> has an average annualized return of about 10 percent.) But if you just leave the money parked in cash, you increase the likelihood that after you retire, you won’t have money at some point. “It’s pretty clear to people which risk they’re more concerned with,” Teutsch said.
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In moments where the market falls, though, it’s easy to get anxious and forget. It can be tempting to panic and sell to try to avoid further losses, without recognizing that in all likelihood those losses will later be recouped.
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That’s why a lot of investors fail, Teutsch said, because “they invest in investments which are more volatile than makes sense for their psychology and then respond to down markets poorly.”
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Think about it: If an investor panicked and sold when stocks crashed in 2020 when the Covid-19 pandemic hit, they would have missed out on a bunch of subsequent gains as the market rebounded. Currently, the markets are down again — and if you panic and sell at lows, you could be out for some big losses in the future. It doesn’t mean you absolutely shouldn’t sell (once again, I cannot give you financial advice), but you should think before you act.
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It’s important to try to keep your emotions in check when your investments are going well, too. You don’t want to get super attached to an investment that’s gone up to the point that you don’t realize it might be time to sell and take some of your gains. Take the example of Peloton, the share price of which soared in the earlier days of the pandemic as people hopped onto the exercise-from-home train. Shares of the stock <a href="https://www.vox.com/the-goods/22895463/peloton-stock-price-bike-cost-production">have now seen deep declines</a>, and the company’s market cap has fallen from a peak of about $50 billion to under $4 billion now. Peloton rides may be really fun and great, but holding onto the stock, not so much.
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<q>Investing is supposed to be boring — and if you’re having fun with it, that might be reason to worry</q>
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“Stop holding onto a stock because you like it,” Myers said. “Just because you like your Tesla doesn’t mean that you need to be heavily invested in the company, especially if the company isn’t doing that well.”
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There’s a gender element here you might want to keep in mind, too — namely, <a href="https://hbr.org/2020/12/how-the-gender-balance-of-investment-teams-shapes-the-risks-they-take#:~:text=Women%20are%20more%20risk%20averse,differences%20in%20appetite%20for%20risk.">women are on average more risk-averse than men</a>. It obviously comes down to the individual, but women might want to take a little more risk than their instincts, and men a little less.
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Keep evaluating
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How you think about risk in investing is something that’s probably going to change over time. How well you’re able to weather downturns might change, say, as you get nearer to retirement, or if you realize you want that money to buy a house. It’s also a good idea to check in on your investments — Myers suggests once a quarter — and consider if you want to make any changes. Check in with yourself about how you’re feeling about where your money is, and whether you’re letting those feelings guide you a little too much.
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“It’s really just always about ruthless questioning of yourself at all times,” Myers said.
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The hard truth, Teutsch explained, is that investing is supposed to be boring — and if you’re having fun with it, that might be reason to worry. A little speculation in moderation is fine, but it’s not the same as investing long-term with a plan. It’s exciting to watch the line go up, but at some point, the line’s going to go down, and you’re not going to be able to guess perfectly ahead of time when it will. “Investment shouldn’t be exciting,” Teutsch said.
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The way to think about markets over the long run is that they’re sort of like walking up a hill with a yo-yo. If you look at the yo-yo, then you see it going up and down and up and down. But if you pay attention to the hill, then you see you still end up on top of it at the end.
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Investing can be intimidating, especially the prospect of losing money. And in moments like the current one, when markets broadly are down, the entire endeavor can feel pretty bad. It’s important to remember things in all likelihood will not be like this forever. (If the stock market were to completely implode, we would probably have much bigger problems on our hands.) But it is also a good moment to think about risk and uncertainty in investing a little, how you feel about it, and make sure some of your feelings are leading you to make decisions you’ll later regret.
</p>
<p class="c-end-para" data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JRJWlM">
“What’s interesting about periods like this is if you’ve never been through it, it will teach you about risk taking,” Pompian said. It’s advice that might not make you feel better right now, but it is true.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="H9LZdV">
<a href="http://www.vox.com/even-better"><em>Even Better</em></a><em> is here to offer deeply sourced, actionable advice for helping you live a better life. Do you have a question on money and work; friends, family, and community; or personal growth and health? Send us your question by filling out this </em><a href="https://docs.google.com/forms/d/e/1FAIpQLSfiStGSlsWDBmglim7Dh1Y9Hy386rkeKGpfwF6BCjmgnZdqfQ/viewform"><em>form</em></a><em>. We might turn it into a story.</em>
</p></li>
<li><strong>Winners and losers from Tuesday’s primaries</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/SxR29lK09EqnNThnZuyfHBBGUHE=/0x345:3208x2751/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71202874/1242275248.0.jpg"/>
<figcaption>
Rep. Sharice Davids (D-KS), right, shares a group hug with women at an election watch party in Overland Park on Tuesday. | Dave Kaup/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Kansas’s abortion measure and Missouri’s GOP senate primary were among Tuesday’s key early races.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6uI9JZ">
Voters in five states — <a href="https://www.vox.com/policy-and-politics/2022/7/30/23284041/arizona-kari-lake-mark-finchem-trump-election-fraud">Arizona</a>, <a href="https://www.vox.com/23273455/kansas-abortion-roe-dobbs-ballot-initiative-constitutional-amendment">Kansas</a>, Michigan, Missouri, and Washington — went to the polls Tuesday to select who will move on to a slew of competitive general election races and, in one case, tell us about the political ramifications of the <a href="https://www.vox.com/2022/6/24/23181720/supreme-court-dobbs-jackson-womens-health-samuel-alito-roe-wade-abortion-marriage-contraception">Supreme Court’s June decision</a> rolling back abortion rights.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NUCvYz">
<s></s>Here are two winners and one loser based on what we know from Tuesday’s results so far.
</p>
<h3 id="aGCobd">
Winner: Abortion rights
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kmrxp1">
Kansas was the first state to put abortion rights on the ballot, in a referendum, since this summer’s Supreme Court decision striking down <em>Roe v. Wade</em>. And abortion rights won big.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NfMQiy">
Kansans rejected an amendment to the state’s constitution that would have removed protections for the right to an abortion, voting to do so by double digits. The Kansas state Supreme Court had previously ruled that the state constitution protected the right to an abortion. This amendment, backed by conservative organizers, would have removed one crucial barrier to the Republican state legislature’s ability to enact more aggressive abortion bans than the 22-week one it currently has.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gW2IOJ">
Tuesday’s outcome is a pretty big statement considering the obstacles abortion rights advocates faced: Confusing wording on the measure (voting “no” meant keeping protections in place), a state where Republicans vastly outnumber Democrats, and a slate of GOP primaries that Republicans hoped would juice their turnout relative to Democrats’.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S552Qq">
This calculus, however, was mistaken. Turnout was massive across the political board, far exceeding the previous two primaries. In Johnson County, which contains suburbs of Kansas City, almost four times as many early votes had been cast this year, compared to the same primary in 2018, <a href="https://www.kansascity.com/news/politics-government/article264065236.html">according to the Kansas City Star.</a>
</p>
<div id="1jxhza">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Secretary of State Scott Schwab says that, based on anecdotal evidence, turnout today may match the turnout in the 2008 presidential general election contest. <br/><br/>That would be around 50% turnout, way above the 36% turnout his office predicted earlier this week. <a href="https://twitter.com/hashtag/ksleg?src=hash&amp;ref_src=twsrc%5Etfw">#ksleg</a>
</p>
— Katie Bernard (<span class="citation" data-cites="KatieJ_Bernard">@KatieJ_Bernard</span>) <a href="https://twitter.com/KatieJ_Bernard/status/1554621379709911041?ref_src=twsrc%5Etfw">August 3, 2022</a>
</blockquote></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5lBNhS">
For now, abortion rights are preserved in a state that, as <a href="https://www.vox.com/23273455/kansas-abortion-roe-dobbs-ballot-initiative-constitutional-amendment">Vox’s Rachel Cohen reported,</a> expects a huge influx of women from neighboring states seeking abortion care. And, for Democrats who saw blowback over the Supreme Court decision as a way to mobilize their voters, the first bellwether is a big win.
</p>
<h3 id="j5QJVQ">
Winner: ERIC (Schmitt, that is)
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vCqhLr">
After months of lobbying from Missouri’s GOP Senate candidates, Trump issued a trollish non-endorsement on the eve of the primary. In a statement on Monday, he said he was “proud to announce that ERIC has my Complete and Total Endorsement!” leaving candidates Eric Greitens, Missouri’s disgraced former governor, and Eric Schmitt, the state’s current attorney general, both empty-handed and happy to issue simultaneous tweets touting the “endorsement.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mEBjoa">
Schmitt wound up beating both six-term Rep. Vicky Hartzler — who had the backing of Sen. Josh Hawley — and Greitens, by double digits. It’s a notable victory for Schmitt, who won without help from Trump, and who is the favorite going into the general election this fall given the <a href="https://www.cookpolitical.com/ratings/senate-race-ratings">state’s Republican tilt</a>. The prospect of a scandal-plagued Greitens winning had many Republicans concerned — and Democrats hopeful for a pickup opportunity. Schmitt has clearly defined himself as a “Trump Republican,” and previously joined other GOP officials to back unsuccessful lawsuits challenging the 2020 election outcomes in other states. But he has a lot less baggage than Greitens, and his win will dampen the likelihood of a safe Republican seat becoming competitive.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5H3oTK">
Schmitt will face off against Democrat Trudy Busch Valentine, a nurse and scion of the famous Anheuser-Busch family, in the general election.
</p>
<h3 id="VivlAI">
Loser: Progressives
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bHZpjg">
Redistricting pitted two Democratic incumbents in Michigan against one another in the 11th district, and incidentally also set up a direct contest between the two wings of the party.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V07tlt">
Progressive Rep. Andy Levin lost that contest to his moderate colleague, Rep. Haley Stevens. The contentious race involved fights over support for Israel (Stevens was backed by AIPAC), appeals to Black voters, and drew in hundreds of thousands in outside contributions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mAlctf">
In the Missouri Senate primary, veteran Lucas Kunce also lost to Busch Valentine after mounting a populist campaign focused on challenging corporate power, and garnering the support of Sen. Bernie Sanders (I-VT).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xcmV8w">
There were bright spots for progressives in Missouri and Michigan, where Reps. Cori Bush (D-MO) and Rashida Tlaib (D-MI) easily held off primary challengers.
</p>
<h3 id="yhhbwb">
Winner, at least in the short term: Democratic meddling in GOP races
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E0F7mr">
Democrats got what they wanted in Michigan’s 3rd district. But there’s a big looming question about whether landing in the winner column is worth it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cLoF1B">
As they have in multiple races this cycle, <a href="https://www.vox.com/23274469/democrats-extremist-republicans-mastriano-cox-bailey">Democrats spent significant money</a> to boost a more extreme, and they hope, more beatable Republican candidate in Trump-backed election denier John Gibbs. And more than they have in other races this cycle, they faced harsh criticism for the tactic from inside and outside their party over their efforts to take down incumbent Rep. Peter Meijer, a rare Republican who voted to impeach Trump.
</p>
<div id="D7zImD">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Gibbs seen here talking to former President Donald Trump. <br/><br/>“I’ll see you soon. I’m very proud of you, John,” Trump could be heard saying through the phone. (h/t John Barnes) <a href="https://t.co/LkIKqs98Io">pic.twitter.com/LkIKqs98Io</a>
</p>
— Riley Beggin (<span class="citation" data-cites="rbeggin">@rbeggin</span>) <a href="https://twitter.com/rbeggin/status/1554696960447324160?ref_src=twsrc%5Etfw">August 3, 2022</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kdT3Vl">
The Democratic Congressional Campaign Committee in this case <a href="https://www.motherjones.com/politics/2022/07/dccc-peter-meijer-john-gibbs-election/">spent more than $400,000</a> in ads linking Gibbs and Trump. Given his massive cash disadvantage to Meijer, it seems the infusion of ads by Democrats was probably decisive. Meijer conceded early Wednesday.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UG0Du0">
Meijer <a href="https://www.commonsense.news/p/why-the-democrats-are-funding-my">castigated Democrats</a> as hypocrites for boosting extremists, and plenty of people agree with him. But other Democrats say it’s justified — it’s ultimately Republicans picking between candidates. “It’s clear that, no matter what Republican is nominated, they are going to get pushed to move to where their base is,” Democratic strategist Jared Leopold <a href="https://www.vox.com/23274469/democrats-extremist-republicans-mastriano-cox-bailey">told Vox’s Nicole Narea</a> last month. “So the best path is to do what you can to set up the best environment for Democrats to win.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k8o57o">
Arizona’s Republican gubernatorial primary, where Democrats spent to boost election denier Kari Lake, has yet to be called. Lake currently has a narrow lead.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DvqRDL">
Gibbs will face Democrat Hillary Scholten in a seat Democrats now have a chance to flip — <a href="https://www.cookpolitical.com/ratings/house-race-ratings"> it’s rated a toss-up by Cook Political Report</a>. But it’s also possible Democrats put another extreme Republican on the path to a seat in Congress.
</p>
<h3 id="RjzgVG">
Winner: Trump acolytes in Arizona and beyond
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dnADrW">
Lake’s race is closer than many Arizonans would have expected earlier this year given Trump’s fervent early backing of her. But his picks dominated other races in the state. His preferred candidates for secretary of state, state Rep. Mark Finchem, and Senate, venture capitalist Blake Masters successfully beat back candidates who held Trump’s election lies at least at arms length. Separately, Arizona House Speaker Rusty Bowers lost a bid for state Senate after previously refusing to challenge the state election results in 2020 and testifying about pressure he faced from Trump <a href="https://www.vox.com/2022/6/21/23177237/january-6-hearings-bowers-raffensperger">before the January 6 committee</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9ysbx0">
These wins were a decisive victory for Trump in a state where establishment Republicans, including his former Vice President Mike Pence and current GOP governor Doug Ducey, backed more establishment picks. All of Trump’s candidates fully embraced the denial in a primary that was <a href="https://www.vox.com/policy-and-politics/2022/7/30/23284041/arizona-kari-lake-mark-finchem-trump-election-fraud">largely focused on relitigating the 2020 election.</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jxb8JW">
Trump saw also got victories in Michigan and Kansas. Businesswoman and political commentator Tudor Dixon, a Trump-backed candidate for the gubernatorial seat, won a five-person primary. Unlike the Arizona candidates, however, Dixon has more recently skirted questions about the 2020 election despite previously arguing that it was stolen. In Kansas, longtime Trump ally and former state attorney general Kris Kobach also won his primary for Secretary of State, his third attempt to return to state government after losing the governor’s race to Democrat Laura Kelly in 2018.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ae4Hxx">
<em><strong>Update on August 3 at 8 am: </strong></em><em>This post has been updated to reflect results in Michigan and Arizona.</em>
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Regal Command, Mozelle and Singer Sargent show out</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Your weekend guide to Chennai’s Covelong Classic: Surf, Music and Fitness festival</strong> - In the run up to the annual Covelong Classic: Surf, Music and Fitness Festival, we put together a quick guide to help you catch a bit of everything</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Commonwealth Games 2022 | Weightlifter Lovepreet Singh wins bronze in men's 109kg</strong> - Lovepreet Singh lifted a total of 355 kg, including a new national record of 192 kg in clean and jerk, to finish third on the podium</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Premier League teams to limit ‘taking the knee’ to significant games</strong> - Players and staff of Premier League teams have been taking the knee since the 2020 killing of George Floyd, but they will henceforth be asked to do it do it only in “significant matches”</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indian mixed 4x400m relay team wins silver with Asian junior record in World U20 Athletics</strong> - The Indian quartet of Barath Sridhar, Priya Mohan, Kapil and Rupal Chaudhary clocked 3 minutes and 17.67 seconds to finish behind USA (3:17.69).</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra Pradesh: Government shuts down Seeds apparel unit, orders probe into gas leak incident</strong> - Industries Minister visits victims in hospital, promises best medical support</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ISRO’s ‘baby rocket’ and it’s umbilical cord with Thiruvananthapuram</strong> - Fully designed and developed by ISRO facilities in Kerala capital</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MCC urges consumers to clear outstanding water tax</strong> - One-time interest waiver offered for domestic consumers</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ED seals Young Indian office in National Herald premises</strong> - The notice pasted under signature of the ED investigating officer outside the YI office space said it cannot be opened “without prior permission” from the agency.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Portion of stonewall damaged in Shravanabelgola</strong> - Stones are spread all over Vindhyagiri</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Russia accuses US of direct role in Ukraine war</strong> - Moscow accuses the US of directly approving targets for US-made artillery used by Ukraine.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nuclear annihilation just one miscalculation away, UN chief warns</strong> - Luck that has protected the world from nuclear war may not last as tensions rocket, the UN warns.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: First grain ship out of Ukraine cleared to sail to Lebanon</strong> - Inspections are completed on the first grain ship to leave Ukraine since the war began.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aliku Ogorchukwu: Wife of Nigerian killed in Italy demands justice</strong> - The wife of the 39-year-old, whose killing was filmed in broad daylight, says her heart is aching.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: The last remaining families in Bakhmut</strong> - Olena and her family are one of the last remaining in the Donetsk region where an evacuation order is in place.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Monkeypox: 25K cases, a batch of new deaths, and 3 state emergencies</strong> - WHO says it’s seeing a broad range of illnesses as more people are infected. - <a href="https://arstechnica.com/?p=1871058">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MIT scientists create color-shifting films inspired by 19th-century holography</strong> - Potential applications include pressure-monitoring bandages, shade-shifting fabrics. - <a href="https://arstechnica.com/?p=1870757">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>3 years after launch, Apple Arcade loses 15 games</strong> - Apple’s game subscription service isn’t immune to the usual downsides. - <a href="https://arstechnica.com/?p=1870961">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>EA cracks down on modders selling their custom Sims 4 content</strong> - But publisher leaves lucrative loophole for “early access” Patreon subscriptions. - <a href="https://arstechnica.com/?p=1870938">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Avowed bitcoin creator Craig Wright is not happy with £1 win in UK libel lawsuit</strong> - What the judge calls “deliberately false,” Wright calls misunderstood evidence. - <a href="https://arstechnica.com/?p=1870911">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Gender is like the twin towers.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
There used to be two of them, and now it is a sensitive subject.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/artemisentreei"> /u/artemisentreei </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/wezffq/gender_is_like_the_twin_towers/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/wezffq/gender_is_like_the_twin_towers/">[comments]</a></span></p></li>
<li><strong>Why do trans women go by she/her?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Because if they went by her/she they’d be chocolate
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/JLW_KING"> /u/JLW_KING </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/wenvuk/why_do_trans_women_go_by_sheher/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/wenvuk/why_do_trans_women_go_by_sheher/">[comments]</a></span></p></li>
<li><strong>Cop : you are driving on the wrong side of the road</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Driver: Sorry, I‘m English
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Cop: (shouting) Oii.. It‘s the rong soid of the roade ye was droivin down, innit?
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Indianfattie"> /u/Indianfattie </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/weg1ze/cop_you_are_driving_on_the_wrong_side_of_the_road/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/weg1ze/cop_you_are_driving_on_the_wrong_side_of_the_road/">[comments]</a></span></p></li>
<li><strong>I like my women how I like my coffee</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I’m not fussy, I’ll have whatever’s available. Thanks.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Diplopicseer"> /u/Diplopicseer </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/weudax/i_like_my_women_how_i_like_my_coffee/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/weudax/i_like_my_women_how_i_like_my_coffee/">[comments]</a></span></p></li>
<li><strong>What’s wet on the inside, hairy on the outside… it starts with C, ends with T, and has a U and N in the middle?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A coconut.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/AlienInUnderpants"> /u/AlienInUnderpants </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/weoaft/whats_wet_on_the_inside_hairy_on_the_outside_it/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/weoaft/whats_wet_on_the_inside_hairy_on_the_outside_it/">[comments]</a></span></p></li>
</ul>
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