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+ + + +A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Combined Modified RNA Vaccine Candidate Against COVID-19 and Influenza. - Conditions: Influenza; COVID-19
Interventions: Biological: Influenza and COVID-19 Combination A; Biological: Licensed influenza vaccine; Biological: COVID-19 Vaccine; Biological: Influenza and COVID-19 Combination B; Biological: Placebo
Sponsors: BioNTech SE; Pfizer
Not yet recruiting
Transcranial Pulse Stimulation (TPS) in Post-COVID-19 - Conditions: Post-COVID-19 Syndrome; Fatigue
Interventions: Device: Transcranial pulse stimulation Verum; Device: Transcranial pulse stimulation Sham
Sponsors: Medical University of Vienna; Campus Bio-Medico University
Not yet recruiting
A Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of Booster Vaccination With Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell) (WSK-V102D). - Conditions: COVID-19
Interventions: Biological: Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell) (WSK-V102D); Biological: Recombinant COVID-19 Variant Vaccine (Sf9 Cell) (WSK-V102); Biological: Placebo
Sponsors: WestVac Biopharma Co., Ltd.; WestVac Biopharma (Guangzhou) Co., Ltd.
Not yet recruiting
Evaluate the Efficacy and Safety of âFormosa 1-Breath Free (NRICM101)â in Subjects With the Symptoms of COVID-19 or Influenza-like Disease - Conditions: Influenza Viral Infections; COVID-19
Interventions: Drug: Formosa 1-Breath Free (NRICM101); Drug: Placebo control drug
Sponsors: China Medical University Hospital; Tian-I Pharmaceutical,. Co. Ltd.; China Medical University, China; Qualitix Clinical Research Co., Ltd.
Not yet recruiting
Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID - Conditions: Long Covid19; Exercise Intolerance, Riboflavin-Responsive
Interventions: Behavioral: Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Behavioral: Light Stretching/Breathing Exercises
Sponsors: Columbia University; New York University
Recruiting
A Pilot Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues - Conditions: Multiple Sclerosis; Long COVID; Long Covid19; Obese; Obesity; Obesity, Morbid; Acute Leukemia in Remission
Interventions: Drug: Liraglutide Pen Injector [Saxenda]; Other: Medication Diary
Sponsors: University of Chicago
Not yet recruiting
EXERCISE TRAINING USING AN APP ON PHYSICAL CARDIOVASCULAR FUNCTION INDIVIDUALS WITH POST-COVID-19 SYNDROME - Conditions: Post-Acute COVID-19 Syndrome
Interventions: Behavioral: Exercise; Behavioral: Control
Sponsors: University of Nove de Julho
Not yet recruiting
A Phase 1 Trial of Recombinant COVID-19 Trivalent Protein Vaccine ïŒCHO CellïŒLYB002V14 in Booster Vaccination - Conditions: SARS-CoV-2; COVID-19 Vaccine
Interventions: Biological: 30ÎŒg dose of LYB002V14; Biological: 60ÎŒg dose of LYB002V14; Biological: placebo
Sponsors: Guangzhou Patronus Biotech Co., Ltd.; Yantai Patronus Biotech Co., Ltd.
Not yet recruiting
COVID-19 Vaccine Effectiveness Against Recurrent Infection Among Lung Cancer Patients and Biomarker Research - Conditions: COVID-19 Recurrent; Lung Cancer; Vaccination; Antibody; Chemotherapy; Immune Checkpoint Inhibitor
Interventions: Biological: Any Chinese government-recommended COVID-19 booster vaccine
Sponsors: Peking Union Medical College Hospital
Recruiting
IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS. - Conditions: Long Covid19; Dietary Supplements; Respiratory Tract Infections; Inflammation
Interventions: Dietary Supplement: Nutritional blend (ImmuneRecov).
Sponsors: Federal University of SĂŁo Paulo
Recruiting
Physical Activity Coaching in Patients With Post-COVID-19 - Conditions: Post-COVID-19 Syndrome
Interventions: Behavioral: Self-monitoring; Behavioral: Goal setting and review; Behavioral: Education; Behavioral: Feedback; Behavioral: Contact; Behavioral: Exercise; Behavioral: Report; Behavioral: Social support; Behavioral: Group activities; Behavioral: World Health Organization recommendations for being physically active
Sponsors: University of Alcala; Colegio Profesional de Fisioterapeutas de la Comunidad de Madrid
Not yet recruiting
Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients by Respiratory Training - Conditions: COVID-19, Post-Acute COVID-19 Syndrome, Dyspnea, Incentive Spirometer
Interventions: Device: breathing training
Sponsors: Tri-Service General Hospital
Active, not recruiting
Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID - Conditions: Long COVID; Post Acute Sequelae of COVID-19; Post-Acute COVID-19
Interventions: Drug: Ensitrelvir; Other: Placebo
Sponsors: Timothy Henrich; Shionogi Inc.
Not yet recruiting
Low-intensity Aerobic Training Associated With Global Muscle Strengthening in Post-COVID-19 - Conditions: COVID-19
Interventions: Procedure: muscle strengthening
Sponsors: Centro UniversitĂĄrio Augusto Motta
Completed
Repurposing ebselen as an inhalable dry powder to treat respiratory tract infections - Respiratory tract infections (RTIs) are one of the leading causes of death globally, lately exacerbated by the increasing prevalence of antimicrobial resistance. While antimicrobial resistance could be overcome by developing new antimicrobial agents, the use of a safe repurposed agent having potent antimicrobial activity against various RTIs can be an efficient and cost-effective alternative to overcome the long and complex process of developing and testing new drugs. Ebselen, a syntheticâŠ
Inhibitory effects against SARSCoV-2 main protease (Mpro) of biflavonoids and benzophenones from the fruit of Platonia insignis - The SARS-CoV-2 mutation and the limitation of the approved drug against COVID-19 are still a challenge in many country healthcare systems and need to be affronted despite the set of vaccines to prevent this viral infection. To contribute to the identification of new antiviral agents, the present study focused on natural products from an edible fruit with potential inhibitory effects against the SARS-CoV-2 main protease (M^(pro)). First, LC-ESIMS analysis of Platonia insignis fruits was performedâŠ
Evaluation of SARS-CoV-2 RNA Rebound After Nirmatrelvir/Ritonavir Treatment in Randomized, Double-Blind, Placebo-Controlled Trials - United States and International Sites, 2021-2022 - Rebound of SARS-CoV-2 shedding or COVID-19 signs and symptoms has been described after treatment with nirmatrelvir/ritonavir (Paxlovid). The direct association of nirmatrelvir/ritonavir to COVID-19 rebound remains unclear because most reports are based on individual cases or nonrandomized studies. Viral RNA shedding data from two phase 2/3, randomized, double-blind, placebo-controlled clinical trials of nirmatrelvir/ritonavir (Evaluation of Protease Inhibition for COVID-19 in High-Risk PatientsâŠ
Synthetic graphene-copper nanocomposites interact with the hACE-2 enzyme and inhibit its biochemical activity - This study demonstrates the copper nanocomposite-induced enzymatic inhibition of human angiotensin I-converting enzyme-2 (hACE-2) by complex stabilization through the formation of the enzyme nanocomposite. The immediate application of this work is related to ACE-2 as a mechanism of SARS-CoV-2 entry into cells. Moreover, ACE-2 enzyme regulation is a potential therapeutic strategy in hypertension and cardiovascular disease, diabetes, lung injury, and fibrotic disorders. Thus, inhibition of ACE-2âŠ
A two-stage design enhanced biodegradation of high concentrations of a C16-alkyl quaternary ammonium compound in oxygen-based membrane biofilm reactors - Quaternary ammonia compounds (QAC), such as hexadecyltrimethyl-ammonium (CTAB), are widely used as disinfectants and in personal-care products. Their use as disinfectants grew during the SARS-CoV-2 (COVID-19) pandemic, leading to increased loads to wastewater treatment systems and the environment. Though low concentrations of CTAB are biodegradable, high concentrations are toxic to bacteria. Sufficient O(2) delivery is a key to achieve high CTAB removal, and the O(2)-based Membrane BiofilmâŠ
CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo - The COVID-19 pandemic has claimed over 6.5 million lives worldwide and continues to have lasting impacts on the worldâs healthcare and economic systems. Several approved and emergency authorized therapeutics that inhibit early stages of the virus replication cycle have been developed however, effective late-stage therapeutical targets have yet to be identified. To that end, our lab identified that 2â,3â cyclic-nucleotide 3â-phosphodiesterase (CNP) inhibits SARS-CoV-2 virion assembly. We showâŠ
Molecular insights to the anti-COVID-19 potential of α-, ÎČ- and Îł-cyclodextrins - SARS-CoV-2 viral infection is regulated by the host cell receptors ACE2 and TMPRSS2, and therefore the effect of various natural and synthetic compounds on these receptors has recently been the subject of investigations. Cyclodextrins, naturally occurring polysaccharides derived from starch, are soluble in water and have a hydrophobic cavity at their center enabling them to accommodate small molecules and utilize them as carriers in the food, supplements, and pharmaceutical industries to improveâŠ
Combined in vitro/in silico approaches, molecular dynamics simulations and safety assessment of the multifunctional properties of thymol and carvacrol: A comparative insight - Bioactive compounds derived from medicinal plants have acquired immense attentiveness in drug discovery and development. The present study investigated in vitro and predicted in silico the antibacterial, antifungal, and antiviral properties of thymol and carvacrol, and assessed their safety. The performed microbiological assays against Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica Typhimurium revealed that the minimal inhibitory concentration values ranged from (0.078 to 0.312âŠ
Molecular dynamics, molecular docking, DFT, and ADMET investigations of the Co(II), Cu(II), and Zn(II) chelating on the antioxidant activity and SARS-CoV-2 main protease inhibition of quercetin - The natural flavonol quercetin (Q) is found in many vegetables, fruits, and beverages, and it is known as a strong antioxidant. Its metal ion chelation may increase its antioxidant activity. The present study aims to explore the Co(II), Cu(II), and Zn(II) chelating on the antioxidant effectiveness and severe acute respiratory syndrome coronavirus 2 (SARSâCoVâ2) main protease (M^(pro)) inhibitory of quercetin using Density-functional theory (DFT), molecular docking, and molecular dynamicsâŠ
Integrated metabolomics and transcriptomics analyses reveal metabolic responses to TGEV infection in porcine intestinal epithelial cells - Transmissible gastroenteritis virus (TGEV) is a coronavirus that infects piglets with severe diarrhoea, vomiting, dehydration, and even death, causing huge economic losses to the pig industry. The underlying pathogenesis of TGEV infection and the effects of TGEV infection on host metabolites remain poorly understood. To investigate the critical metabolites and regulatory factors during TGEV infection in intestinal porcine epithelial cells (IPEC-J2), we performed metabolomic and transcriptomicâŠ
Inhibition potential of natural flavonoids against selected omicron (B.1.19) mutations in the spike receptor binding domain of SARS-CoV-2: a molecular modeling approach - The omicron (B.1.19) variant of contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is considered a variant of concern (VOC) due to its increased transmissibility and highly infectious nature. The spike receptor-binding domain (RBD) is a hotspot of mutations and is regarded as a prominent target for screening drug candidates owing to its crucial role in viral entry and immune evasion. To date, no effective therapy or antivirals have been reported; therefore, there is anâŠ
Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses - Innate immune responses to coronavirus infections are highly cell specific. Tissue-resident macrophages, which are infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients but are inconsistently infected in vitro, exert critical but conflicting effects by secreting both antiviral type I interferons (IFNs) and tissue-damaging inflammatory cytokines. Steroids, the only class of host-targeting drugs approved for the treatment of coronavirus disease 2019 (COVID-19),âŠ
Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition - Mycobacterium tuberculosis, the causative agent of tuberculosis, is a growing threat to global health, with recent efforts towards its eradication being reversed in the wake of the COVID-19 pandemic. Increasing resistance to gyrase-targeting second-line fluoroquinolone antibiotics indicates the necessity to develop both novel therapeutics and our understanding of M. tuberculosis growth during infection. ParDE toxin-antitoxin systems also target gyrase and are regulated in response to bothâŠ
Unraveling viral drug targets: a deep learning-based approach for the identification of potential binding sites - The coronavirus disease 2019 (COVID-19) pandemic has spurred a wide range of approaches to control and combat the disease. However, selecting an effective antiviral drug target remains a time-consuming challenge. Computational methods offer a promising solution by efficiently reducing the number of candidates. In this study, we propose a structure- and deep learning-based approach that identifies vulnerable regions in viral proteins corresponding to drug binding sites. Our approach takes intoâŠ
Inhibition of SARS-CoV-2 NSP-15 by Uridine-5â-Monophosphate Analogues Using QSAR Modelling, Molecular Dynamics Simulations, and Free Energy Landscape - SARS-CoV-2 is accountable for severe social and economic disruption around the world causing COVID-19. Non-structural protein-15 (NSP15) possesses a domain that is vital to the viral life cycle and is known as uridylate-specific endoribonuclease (EndoU). This domain binds to the uridine 5â-monophosphate (U5P) so that the protein may carry out its native activity. It is considered a vital drug target to inhibit the growth of the virus. Thus, in this current study, ML-based QSAR and virtualâŠ
How Netanyahuâs Right-Wing Critics See Israelâs Future - Danny Danon, the former Israeli Ambassador to the United Nations, believes thereâs no path forward for a Palestinian state. - link
An Unpermitted Shooting Range Upends Life in a Quiet Town - Residents of Pawlet, Vermont, were accustomed to calm and neighborly interactions. Then a new resident moved in. - link
There Are No Safe Places in Gaza - As Israelâs military campaign has expanded into southern Gaza, displaced families have been forced to move again and again. - link
Coloradoâs Top Court Kicked Trump Off the Ballot. Will the Supreme Court Agree? - A legal scholar analyzes how the nine Justices are likely to view the blockbuster decision. - link
When Americans Are the Threat at the Border - Many people charged with trafficking in Tucson are U.S. citizens, suffering from the same problems of poverty and addiction that plague the rest of the country. - link
+What Oppenheimer, Napoleon, Maestro, and Ferrari have to say about the men at their centers. +
++This has been a banner year for movies about Great Men. +
++Now first let me clarify what I mean by the term Great Men. I donât mean âmen who are good,â for instance. This is not a moral judgment. Great Men can be bad men as well â bad for society, bad to their loved ones, etc. I mean, rather, movies about towering male figures whose names convey a certain amount of awe. Men like father of the atomic bomb J. Robert Oppenheimer, composer Leonard Bernstein, French Emperor Napoleon Bonaparte, and carmaker Enzo Ferrari. These are men who have made an impact on the world, sometimes for ill. They are men history has deemed worthy of studying and that filmmakers with big budgets behind them have deemed worthy of exploring. +
++But the Great Man movie presents an interesting challenge: The directors donât need to prove that their subjects are interesting â decades of media coverage have done that â they need to prove why they can tell their stories in an engaging way that doesnât feel like a Wikipedia entry and actually captures the essential mystique of these guys. +
++With Oppenheimer, Maestro, Napoleon, and Ferrari, Christopher Nolan, Bradley Cooper, Ridley Scott, and Michael Mann, respectively, have all seemingly taken on a challenge to reinvent the biopic formula as they pursue their passion projects about these icons. While their films differ in tone and execution, theyâve all attempted in similar ways to subvert typical biopic conventions. +
++With Oppenheimer, Christopher Nolan makes his intentions plain on the first page of his screenplay. âPeer into my soul,â he writes. âJ. Robert Oppenheimer, aged fifty, close-cropped greying hair.â +
++Nolan wrote his script for the blockbuster film in the first person, essentially taking on the persona of the man behind the invention of the most destructive weapon the world has ever seen. You can see this as an act of hubris on the part of the director, but it is also a mission statement: Nolan wants to crack open Oppenheimerâs brain. His goal is not just to unpack his brilliance but also the guilt that arises after the US government takes his discovery and uses it to destroy Hiroshima and Nagasaki. +
+ ++With his understanding of theoretical physics, Oppenheimer can envision the cosmos. Nolan uses those visions as both a demonstration of his intelligence and his capacity for harm. What at first seem like interludes to demonstrate Oppenheimerâs scientific imagination â shots of contextless explosions â morph into the horrors that plague his mind once the bomb has been deployed. Nolan uses Oppenheimerâs own tools to explain him, and to a certain extent, so do Cooper, Scott, and Mann. +
++As Cooper tackles Leonard Bernstein in Maestro â both as director and in the lead role â he tries to use Bernsteinâs music as a way into his psyche. Cooper consciously stays away from trying to expressly articulate what made Bernstein a great composer and conductor, a choice that can be frustrating for viewers who want a simple timeline of his highs and lows. Instead, he offers musical sequences that seek to capture the chaos of living as Bernstein, a man of effusive love, who was also semi-closeted, seeking relationships with men outside his marriage to Felicia Montealegre (Carey Mulligan). The most successful of these moments are the dream dance, wherein Lenny and Felicia are drawn into a production of âFancy Free,â the ballet Bernstein composed for Jerome Robbins, and the performance of Mahlerâs Symphony No. 2 at Ely Cathedral in the UK. The latter offers no magical realism, but Bernsteinâs (and in turn Cooperâs) effort is magical. You can see the effect he has on people in that exertion and the way he throws himself into his work. +
+ ++For Michael Mann, the director of Ferrari, his hero is like his engines: powerful but sometimes almost mechanical in his ambition. The sound of these contraptions is what fuels Mannâs film, a hum of energy that is almost like a score, and Driver seems to match his performance to that rhythm. He barrels into scenes with the furor of his cars, which, it should be noted, are also death traps, a pertinent detail. Enzo is surrounded by death, specifically the death of his son Dino, who has passed before the movie begins. +
+ ++Speaking of death: War is the tool by which Ridley Scott illuminates Napoleon (Joaquin Phoenix). Itâs through the impeccably staged, if not particularly accurate, battle sequences we can see Napoleonâs cunning and insecurity. Heâs an ingenious strategist who does not know when to stop, his self-aggrandizement taking precedence over everything else. +
++Whether physics, music, cars, or war, the filmmakers try to use what makes these men so revered as a way of both idolizing and humanizing them. The audience may not relate to their genius, but they can understand it through what they produced. In turn, the hope is that we can also understand their torment. +
++What is a Great Man without the women around him? All of these films try to define their Great Men by their key relationships, and, yet, this is where they most often falter. For as much as each of these (male) directors tries to put the wives and girlfriends of these guys on equal footing, they are still mostly hypnotized by the Great Man himself. +
++Itâs in Ferrari that this seems like the biggest stretch. Mann sets his film during a period of Enzo Ferrariâs life in 1957 where Enzo is pulled between his wife and business partner Laura (PenĂ©lope Cruz) and his mistress Lina Lardi (Shailene Woodley) with whom he has a young child. Enzo and Lauraâs son has died, and Enzo is resistant to allowing Linaâs child to bear his name â a sign of guilt. Both these female characters fall into easy archetypes: Laura is fiery and persistently furious. She is wracked by grief and understandably angry at Enzo for his philandering. Lina, meanwhile, is a patient and calming force, almost a motherly figure both to Enzo and his illegitimate heir. They are each reduced to the proverbial angel and devil on his shoulders. +
++This mistress-versus-wife paradigm is also present in Oppenheimer, which has slightly more success with the dynamic. Oppenheimerâs lover Jean Tatlock (Florence Pugh) isnât as developed a character as her real-life counterpart deserves â she led a fascinating life that gets short shrift in the movie â but her presence is nonetheless haunting. Tatlock is a physical representation of the way humans are collateral damage for Oppenheimer, as evidenced by her disturbing death likely by suicide but possibly by assassination over Communist ties and connection to Oppenheimer. (A gloved hand alludes to the latter, which remains just a theory.) Meanwhile, Oppenheimerâs wife Kitty (Emily Blunt) serves as an example of the way the heartbreak of loving a person like him can harden someone. After they wed, she quickly falls into alcoholism but is loyal to the end, especially in her crucial testimony scene. Being in his presence has certainly taken a toll. +
+ ++The difficulty of being married to a Great Man is never more evident than in Napoleonâs relationship with Josephine (Vanessa Kirby) in Napoleon. His love letters to her offer a sort of framework for the film, but that love is both suffocating and deficient. He punishes her when she cheats on him, and when she canât bear him an heir he divorces her and takes away her title. +
++Cooper, meanwhile, tries the hardest to put Bernsteinâs spouse on equal footing, framing Maestro essentially as the complicated love story between Lenny and Felicia. Still, it is a love story about what it means to love a Great Man. Mulliganâs performance is a wonderful demonstration of a woman compartmentalizing her feelings. She wants to love Lenny and all of his facets â knowing about his bisexuality â but finds she is fighting to define herself as he strays. That in itself makes her a secondary figure in the narrative. For as much as Maestro is about Lenny and Felicia, Lenny is still the main draw and Feliciaâs arc is partly about her knowing that. +
++Itâs the ultimate conundrum of all of these movies. As much as someone may try to subvert the myth of the Great Man, it is hard not to fall under his spell. All of these movies have their moments of virtuosity, some more than others, and when they are at their best they capture why the Great Man is so entrancing. +
+The shifting value of going out to eat. +
++2023 was a year of extremes in eating: We went out to buzzy restaurants with the flamboyant ambience of nightclubs â or we sat at home, scrounging up two olives and a tortilla chip for a girl dinner. More often, it was the latter. +
++As the dust settles around a turbulent couple of years of being stuck at home or stuck in outdoor dining bubbles, itâs clear that something has changed in dine-out culture. There are no longer Covid lockdowns or social-distancing rules restricting businesses and patrons, and other activities â like air travel and concerts â have either fully recovered to pre-pandemic levels or even surpassed them. Overall, consumer spending is strong. But weâre still dining out less than we used to. +
++And while we are going out to eat less (according to location analytics firm Placer.ai, visits to sit-down restaurants this past quarter were down nearly 5 percent year over year), when we do eat out, experts told Vox, weâre flocking to the hottest of fine-dining spots that have gone viral online. The spontaneity of a dinner at a new Neapolitan pizzeria or ramen shop several times a week is gone; this year, dining out became rarefied. +
++Ballooning bills at restaurants may have pushed us in these wildly divergent directions. People spent more on restaurants this year even as visits fell because of the rising prices of everything from ingredients (whether itâs meat, sugar, or butter) to labor. Amid the grousing about the cost of eating out, however, came a personal reevaluation of what we want out of a visit to a restaurant â what we get out of the experience and how much thatâs truly worth. +
++To be clear, there hasnât been an exodus from restaurants, exactly, but the anticipated rebound from the pandemic is stalling. +
++We still left our homes in search of convenient food. Visits to fast food joints, fast casual places (think Cava or Chipotle), and specialty coffee stores â places where takeout remains a popular option â saw increased traffic most of this year compared to 2022. Late-night Taco Bell runs were way up. But anywhere youâd sit down to eat and tip afterward drew sparser crowds. +
++The drop-off is steeper depending on where you look. Itâs been a âterrible yearâ for restaurants in San Francisco, says Soleil Ho, a food writer and cultural critic at the San Francisco Chronicle. Local reports note empty dining rooms and waves of restaurant closures. âItâs actually a sort of hangover from the pandemic,â Ho says. Restaurants in the Bay Area, home to one of the hottest food cities of the 2010s, have been among those struggling hardest in the country to regain their pre-Covid bustle. Tech layoffs have hit the region hard, tightening belts and clearing out the once-busy downtown landscape. In a city like San Francisco, that leaves its mark on the dining scene. +
++âWhen I was a restaurant critic, I would go out to these Michelin-starred restaurants on the weekdays,â Ho says. âA lot of times, the people around me were in tech â they were just there casually, spending $300 a meal, just to hang out and look at their phone and eat a tasting menu.â These tech workers were the backbone of the cityâs fine-dining scene, and Ho sees them much less now. +
++Khushbu Shah, contributing editor at Food & Wine and the Los Angeles-based author of the food newsletter Tap Is Fine, echoes the sentiment. Shah says the restaurant industry there is starting to feel âsome of the reverberations of the pandemic now,â years out from lockdowns, in part because the Covid aid for businesses and customers has finally run out. +
++Itâs unclear how many restaurants closed for good because of Covid, though a Washington Post estimate last year said that there were 72,700 more restaurant and bar closures than normal in 2020. Restaurant openings rose this year, but there are still fewer places to eat than before. +
++According to OpenTable, the restaurant reservation site, there were 19 percent fewer diners in 2021 than there were pre-pandemic. In 2022, restaurants rebounded but were still nearly 4 percent short. This year, that number dipped an additional percentage point. Almost three years later, people still arenât back in the swing of a beloved social pastime. +
++Maybe the answer to the decline in going to restaurants is mind-numbingly simple: They got too expensive. Since January 2020, Bloomberg found, menu prices have soared by a hard-to-stomach 24 percent. But itâs likely that thereâs something more than price at play. Thereâs a kind of fatigue setting in as wait times for walk-ins at the most popular restaurants grow and getting a reservation has become a competitive sport. If people are eating out less because of the expense, why does it feel like even more of a rat race to get a table? +
++Inflation has walloped restaurants; just look at any breakdown of why a particular menu item costs as much as it does now, whether itâs a $32 lobster roll or a $30 shrimp cocktail. Certain staple ingredients have soared in price, but when the charge for particular dishes double or triple, particularly in fine dining, itâs hard to see the increase as anything but opportunistic. New York-based food critic Ryan Sutton, who writes The LO Times newsletter, has been tracking some of the most egregious increases. +
++âI think to a certain extent, youâre seeing people getting priced out of restaurants, even though you arenât necessarily seeing those restaurants do poorly,â Sutton tells Vox. +
++In a metropolis like New York, thereâs a hefty segment of wealthy people who can afford a four-figure dinner. There are still crowded restaurants and long lines. Meanwhile, while inflation has slowed and the unemployment rate is almost as low as it was in 2019, the onslaught of layoffs that received so much attention last year have not only continued, but intensified. The people absent from the dining scene because theyâre tightening their belts on luxuries, particularly as pandemic relief has been fully depleted and student loan payments have returned, are by nature invisible. +
++Even people who could afford to splurge on more meals out may be struggling to adjust to the âpsychological aspectâ of paying $25 for a martini, says Sutton. Itâs a turn-off because higher prices happened quickly â they arrived like a burst of flame, not a frog being slowly boiled in a pot. +
++At the same time, in Austin â the Texas capital sometimes called Silicon Valley 2.0 â the well-paying tech industry has been fueling the growth of high-end restaurants with broad appeal, such as restaurants serving, say, New American cuisine with pricey burgers. Or the latest craze in the city, according to Eater Austin editor Nadia Chaudhury: omakase, an ultra-upscale style of Japanese dining where an entire multi-course meal is curated and prepared in front of you by the chef. It can run hundreds of dollars per person. +
++Itâs a sign of how peopleâs sense of value has been jostled. Itâs go big or go home. When people do go out to eat, theyâre frequently seeking out the most viral (like Bad Roman), most feted (like Tatiana), even the most expensive places. Yelp reports that interest in four-dollar-sign restaurants on its platform, which indicates the priciest options, has been consistently rising since the pandemic. +
++Eating out, as a result, has become an exhausting hustle, requiring cunning and perseverance. For places diners really want to get into, there are a raft of how-to guides and people are even using under-the-table group chats to bypass the usual reservation system. Sutton recalls that at Sailor, a new bistro in Brooklyn, he was recently quoted a four-hour wait. The phenomenon has spawned a modern-day version of the old Yogi Berra joke: âNobody goes there anymore. Itâs too crowded.â +
++âEither a restaurant has lines out the door or theyâre begging people to come in,â says Shah. Those in-between spots â the restaurant doing just okay â are fewer and farther between. +
++In some ways, it has to do with capital. The omakase-style restaurant is the perfect type of ritzy place to attract investors and big restaurant groups, and a perfect example of dining out becoming increasingly bifurcated into two extremes. The restaurants that succeed really succeed and tend to be backed by investors. The ones that struggle really struggle. +
++Thereâs no dearth of creative, passionate people wanting to open a unique place to dine, but itâs not enough to be talented if you donât have ample capital. In 2020, the number of independent restaurants â those that have just one or two locations â fell by 8 percent. It recovered just 1 percent last year. Rising rent has left independent restaurants struggling to keep their doors open. Meanwhile, chain restaurants have boomed, flattening the diversity of the dining scene. +
++The experience of dining out is also more likely to be treated as entertainment now, says Sutton â a bombastic experience where thereâs loud music, wild lighting, or mixologist-crafted jello shots. But if a restaurant is an entertainment venue, few other options in the category have seen as much price inflation in the past few years. âYou do not see theater ticket prices doubling,â notes Sutton, though they have indeed gone up. +
++It makes sense, then, that people are more precious about where they eat. If a restaurant experience isnât remarkable, is it worth the astronomical price and the hassle of getting in? +
++For me, personally, 2023 has been the year of casual dinner parties â get-togethers of four or five people, where we eat a home-cooked meal and thereâs no 90-minute time limit before we have to leave the table. +
++âIf you feel like going out to eat tonight, and you go to a place and thereâs an hour wait, youâre gonna get frustrated, right?â says Chaudhury. âSo itâs just easier to go to a friendâs house, honestly.â +
++The fact is, going to restaurants peaked more than two decades ago. In 2000, the average American went out to eat about 216 times. By 2018, it was down to 185 times. It raises the question of whether eating out less in 2023 was part of a long slide back to normal rather than a failure to return to the status quo. +
++Restaurants are old, but dining out only became more affordable for the average American in relatively recent decades â a New York Times piece from 1985 reports on a âdramatic change in the eating habits of many Americansâ who increasingly sought out restaurants. Around this time, the âfoodieâ was born. +
++Through the decades, the state of the restaurant industry has only rarely not appeared to be touch-and-go. In the mid to late 2010s, there were murmurs of a restaurant bubble poised to pop at any moment. Food journalist Kevin Alexander documented how scores of independent establishments were shuttering, unable to keep up with rising rent, labor costs, and âa pandemic of similar restaurantsâ making it hard to stand out from the pack. In short, it was too hard to run a restaurant, and it was too hard working in a restaurant. âOne of the unintended consequences of the Golden Age of Restaurants was unreasonable customer expectations for virtually every eating experience,â Alexander wrote. +
++Those 2016 observations may have been a harbinger of what was to come, right down to the word âpandemic.â Among the common reasons people give for why they eat out less now is the amorphous feeling that thereâs been a decline in service quality, one Pymnts survey confirms â a further degradation of the experience for which theyâre paying much more in 2023. And they may not be wrong: There are fewer people working in restaurants today than before the pandemic. What weâve gained instead is a more honest reckoning of whatâs on the menu: what it costs to prepare a meal â sometimes multiple courses of it â and have a human serve it to you. +
++Some of the menu inflation has gone to wage increases for restaurant workers. Data from the Bureau of Labor Statistics says the median hourly wage in May 2022 for servers (which includes tips) was $14, up from $11 in May 2019, which means a server working 40 hours a week all year would have gone from making about $22,880 to $29,120 before taxes. Meanwhile, the work remains grueling; itâs still dangerous, especially when Covid-19 cases flare back up again periodically. And in the last few years, Americans have become notably worse tippers. According to an annual Bankrate survey, 77 percent said they always tipped at table-service restaurants in 2019. This year, only 65 percent did. Perhaps to combat this and retain staff, many restaurants have added automatic gratuities to checks, further irking some diners. +
++What we pay for when we dine out isnât just the sustenance, but an alchemy now most often called âvibesâ â the lighting, the decor, the crowd, whatever banter is shared with your server. Thereâs so much pleasure in being inside a great restaurant, but thereâs an undercurrent of discomfort, too. Itâs an experience where, for a few hours, another human being is entirely focused on your satisfaction. As in so many service jobs, thereâs an inequality of power baked into the interaction, a vibe that has become harder to ignore since 2020. Food and culture writer Alicia Kennedy has summed up this tension as a kind of hostility lurking within hospitality: âOne person has to be nice, the other person does not.â This discomfort has always existed, but the difference today is that we name it more explicitly and put a higher price on the labor of tolerating it. +
++There is something sad about the idea that the restaurantâs presence in our day-to-day lives may be shrinking. The last thing I did before New York locked down was to have dinner at a neighborhood Vietnamese spot. It was elegant and well-known, yet the reservation was a breeze to get, and looking at the bill didnât feel like a gut punch. After all, the relaxed pleasure of being ensconced elbow to elbow with other people, getting a little full and a little drunk, is almost too gratifying to pin a price on. +
++And maybe thatâs the confusion, the internal debate, weâre seeing play out now. What is dining out worth today? When is it worth that? For many, on most days, when the cost doesnât meet the threshold â home cooking it is. For others, on certain special occasions, thereâs still no better place to enjoy a meal than a popular restaurant. Its value may have even gone up, in recognition of all that a meal out can provide: a break from the mundane, a place to be seen, where someone is always nice to you. +
+Is there a future for Jason Momoaâs Aquaman? +
++Spoiler warning: This post contains spoilers for Aquaman and the Lost Kingdom. +
++Aquaman and the Lost Kingdom is truly so much movie. The film marks the return of Aquaman a.k.a. Arthur Curry (Jason Momoa) â who, after ascending to the throne of Atlantis, has to fight off David Kaneâs a.k.a. Black Mantaâs (Yahya Abdul-Mateen II) attack on the undersea kingdom, complete with light necromancy and zombies, a sonic death gun, and a cephalopod sidekick. The adventure takes our hero to the deep sea, a mutant jungle, a parched desert, and Antarctica, and includes themes about global warming and racism (apparently, Atlanteans have extreme prejudice against surface dwellers). The movie has a feeling of finality â not just for the soggy king, but the entire DC Comics onscreen universe as weâve known it. +
++Given all that, and especially with Momoaâs future as Aquaman in doubt, was there anything left for Warner Bros. to show in a credits scene? Another adventure, perhaps? +
++Aquaman 2 has one credits scene, and itâs a callback to one of the movieâs goofy jokes. +
++In the film, Aquaman has to free his brother Orm (Patrick Wilson) from the Deserters, which involves him breaking into a maximum-security desert jail. (For citizens of Atlantis, being far from water is its own kind of punishment.) The two go on a quest to fight Kane, but not before Aquaman plays a joke on his little brother. +
++Orm hates the surface world, but Aquaman tells him that his prejudice is limiting his life. Ormâs mindset means missing out on good things like hamburgers, beer, and tacos. Orm begins to soften his view after hearing all these fantastic things â mostly food, mostly alcohol â that his brother canât stop gushing about. Aquaman then picks up a cockroach and tells his brother that theyâre the shrimp of the land and people eat them all the time. Intrigued, Orm gobbles one up and likes the taste, much to Aquamanâs dismay. +
++The credits scene shows Orm finally enjoying the burger and beer his brother waxed poetic about, but not before a cockroach crawls on the table. Orm crushes the bug, stuffs it into his burger, and takes a big bite. A huge smile stretches over Ormâs face as he savors the taste, and the scene cuts to black. +
+ ++Obviously, the credits scene is a reference to Ormâs gross taste but also, on a positive note, his openness to rethinking his prejudices and finding beauty in the surface world. It also seems to indicate that this iteration of Aquaman is done. +
++Usually, credits scenes tease our heroâs next movie. Both Warner Bros. and Marvel have done this quite a bit, introducing superhero teams and even some villains in their movie credits scenes. But for Warner Bros.â heroes especially, that future looks a little more bleak. +
++In October, director James Gunn and Peter Safran were named co-chairs and co-chief executive officers of DC Studios â the people in charge of superhero storytelling. When Gunn and Safran were appointed, a cinematic overhaul of the universe was announced with a new slate of projects on the horizon. None of those future projects featured the studioâs existing iterations of its heroes, including Aquaman, Shazam, and the Flash. Since then, the Shazam sequel and the Flash standalone were considered box office bombs, which certainly doesnât inspire a lot of confidence in their future appearances. +
++With Aquaman 2âs credits scene opting to go for a joke, paired with the movieâs extremely tidy ending and no big bad on the horizon, thereâs no tease for Aquamanâs next big adventure â unless itâs all about sharing a burger with his brother. +
Bajrang Punia to return Padma Shri in protest over WFI chief election - Bajrang Puniaâs decision to return the award comes a day after Sakshi Malik announced retirement from wrestling because Sanjay Singh, a Brij Bhushan Sharan Singh loyalist, was elected as the WFI president
NATIONAL SHOOTING TRIALS | Sift Kaur Samra tops rifle 3-position with ease - Rhythm Sangwan is in top form in the womenâs 25-metre sports pistol, beating qualification topper and Olympic quota winner Manu Bhaker
Virat Kohli returns due to family emergency, Gaikwad ruled out of Test series against South Africa - Virat Kohli is expected to be back in time for the first Test against South Africa in Centurion on December 26.
Khawaja to challenge ICC reprimand, says armband was for a bereavement - ICC regulations prevent cricketers from displaying messages of political, religious or racial causes during international matches
Unfortunately havenât been able to give Samson chance at No. 3, says K.L. Rahul - Samson, elevated to No.3 spot, smashed his maiden ODI century in the third and final match against the Proteas on December 21 as India won by 78 run
Here are the big stories from Karnataka today - Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today.
Centre authorises release of âč1,404.5 crore to Kerala as âadditional instalmentâ of tax share - This is in view of upcoming festive season
What causes inflation in India: Demand or supply issues? | Data - Supply-side factors account for about 55% of the CPI headline inflation, an RBI article concludes
Delhi court grants police 60 more days to complete NewsClick probe - The court passed the order on a plea moved by the Delhi Police that sought more time to complete the investigation
How homes in Thiruvananthapuram get a makeover for Christmas - Home-proud residents on bringing home the Christmas cheer
Stunned Prague students mourn and no-one mentions killer - A shrine appears outside a university building for the 14 students murdered in Pragueâs Old Town.
âBlood all over the facultyâ - eyewitnesses recount Prague attack - Fourteen people were killed in the worst mass shooting in Czech history on Thursday.
Prague: Dramatic video from city shows people leaping from building ledge - A gunman entered Charles University killing 14 people in one of the countryâs worst fatal shootings.
France closes Niger embassy after row with military junta - Nigerâs military leaders have ordered all French troops to leave the country by Friday.
France split over environmental effects of Christmas trees - The majority of the Christmas tree plantations in Burgundy rely on the use of chemical treatments.
Rocket Report: Vulcan stacked for launch; Starship aces test ahead of third flight - âWe look forward to flying our next crewed flight soon.â - link
Laptopsâ 2023 quantum leap: 5 computers weâll still be talking about in 2024 - You likely didnât want these PCs this year, but they may impact your future devices. - link
Debt-laden Warner Bros. Discovery and Paramount consider merger - WBD could have 2nd most streaming subscribers if reported meeting leads to deal. - link
Google might already be replacing some Ad sales jobs with AI - When AI can make assets and text for ads, you donât need humans to do it anymore. - link
Galaxy-scale winds spotted in the distant Universe - These winds can drive gas out of galaxies, shaping their future evolution. - link
I met a girl at a bar one night. -
++We hit it off pretty well and she brought me back to her place. We had a nightcap before she invited me to her bedroom. Surprisingly, she had a real thing for stuffed animals, and they took up all the wall space in her room, literally stacked from floor to ceiling. Hell, I didnât care; I was ready to get down to business. And get down to business I did. I pulled out all the stops. I was really quite impressed with my passion and stamina by the time things wound down and as I lay there, catching my breath, I eventually turned to her and asked, âso, was that as good for you as it was for me?â +
++âUhh, choose any item from the bottom shelf.â +
+ submitted by /u/bumpy713
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TV crew goes to the countryside -
++
A TV crew goes down to a farmer to explore how a day in the countryside unfolds. They ask him to describe how his day goes.
+ ++
+
+
Sister Mary Had a Question for her 4th Grade Class -
+
+Sister Mary asked her students, âDoes anyone know what part of your body goes to heaven first?â
Little Johnny excitedly raised his hand in the back, but Sister Mary, with a practiced smile, called on Suzy instead.
âThe heart, Sister,â Suzy declared, âbecause thatâs where we hold our love for Jesus!â
âA delightful answer, Suzy,â Sister Mary beamed. âDoes anyone else have a different thought?â
Johnnyâs hand shot up again, but Sister Mary hesitated. Instead, she addressed another student, Margaret.
âThe brain, Sister,â Margaret said confidently, âbecause thatâs where we contemplate Jesus and his teachings.â
âGreat answer, Margaret! I appreciate your thoughtful response.â
Finally, only Johnnyâs hand remained raised. Begrudgingly, Sister Mary called on him.
âYes, Johnny?â
âThe feet, Sister,â Johnny said.
Sister Mary raised an eyebrow. âOkay, Johnny, why do you think your feet are the first thing to go to heaven?â
âWell, the other day, I walked into my parentsâ room and my motherâs feet were in the air, and she was yelling, âIâm coming, God! Iâm coming!â
+
submitted by /u/FunnyKozaru
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A guy and his monkey walks into a bar -
++The monkey grabs some olives off the bar and ate them. Then he grabbed some sliced limes and ate them. He then jumped onto the pool table and grabbed one of the balls. To everyoneâs amazement he stuck it in his mouth and somehow swallowed it whole. +
++The bartender looked at the guy and said +
++âDid you see what your monkey just did?â +
++âNo, what?â +
++âHe just ate the cup ball off my pool table. Whole!â +
++âYeah that doesnât surprise me, he eats everything in sight. Donât worry, Iâll pay for the cue ball.â +
++The man finishes his drink, pays his bill, paid for the stuff his monkey ate and left. +
++Two weeks later the man came back and had his monkey with him. He ordered a drink and the monkey started to run around the bar. He found a cherry, grabbed it and stuck it up his ass, pulled it out then ate it. Then the monkey found a peanut and then once again stuck it up his ass, pulled it out,then ate it. +
++The bartender asks, âDid you see what that filthy ape just did?â +
++âNo, what?â +
++âHe stuck both a cherry and peanut up his arse, pulled it out, then ate them!â +
++âYeah that doesnât surprise me. Heâll eat anything. But ever since he had to shit out that cue ball, he measures first.â +
+ submitted by /u/HospitalQuiet619
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Three Men Sit in a Russian Prison Cell -
++Two recently arrested men share a prison cell along with a mysterious stranger, quietly awaiting his fate in the shadows. Clutching the prison bars, the two new arrivals strike up a conversation. +
++The first man asks: âSo what are you in for?â +
++The second man replies: âThe NKVD arrested me because I supported Menshnekov.â +
++The first man is clearly surprised. âHuh. Iâm in here because I was against Menshnekov.â +
++They both turn around to find the mysterious stranger slowly leaning forward into the light. âIâm in here because I AM Menshnekov!â +
+ submitted by /u/form_d_k
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