navan
/
Daily-Dose
mirror of https://github.com/navanchauhan/Daily-Dose.git
1
0
Fork 0
Code Issues Projects Releases Wiki Activity

Added daily report

This commit is contained in:
Navan Chauhan 2023-04-23 12:44:14 +00:00
parent e7436966dc
commit c777d59435
3 changed files with 610 additions and 2 deletions
Show Stats Download Patch File Download Diff File Expand all files Collapse all files

184
archive-covid-19/23 April, 2023.html Normal file
View File

@ -0,0 +1,184 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>23 April, 2023</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
ul.task-list{list-style: none;}
</style>
<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta infections</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Protection against SARS-CoV-2 symptomatic infection and severe COVID-19 of previous infection, mRNA two-dose vaccination, mRNA three-dose vaccination, and hybrid immunity of previous infection and vaccination were investigated in Qatar for the Alpha, Beta, and Delta variants. Methods: Six national, matched, test-negative, case-control studies were conducted between January 18-December 18, 2021 on a sample of 239,120 PCR-positive tests and 6,103,365 PCR-negative tests. Results: Effectiveness of previous infection against Alpha, Beta, and Delta reinfection was 89.5% (95% CI: 85.5-92.3%), 87.9% (95% CI: 85.4-89.9%), and 90.0% (95% CI: 86.7-92.5%), respectively. Effectiveness of two-dose BNT162b2 vaccination against Alpha, Beta, and Delta infection was 90.5% (95% CI, 83.9-94.4%), 80.5% (95% CI: 79.0-82.0%), and 58.1% (95% CI: 54.6-61.3%), respectively. Effectiveness of three-dose BNT162b2 vaccination against Delta infection was 91.7% (95% CI: 87.1-94.7%). Effectiveness of hybrid immunity of previous infection and two-dose BNT162b2 vaccination was 97.4% (95% CI: 95.4-98.5%) against Beta infection and 94.5% (95% CI: 92.8-95.8%) against Delta infection. Effectiveness of previous infection and three-dose BNT162b2 vaccination was 98.1% (95% CI: 85.7-99.7%) against Delta infection. All five forms of immunity had &gt;90% protection against severe, critical, or fatal COVID-19 regardless of variant. Similar effectiveness estimates were observed for mRNA-1273. Conclusions: All forms of natural and vaccine immunity prior to Omicron introduction provided strong protection against infection and severe COVID-19. Hybrid immunity conferred the strongest protection and its level was consistent with previous-infection immunity and vaccine immunity acting independently of each other.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.04.21.23288917v1" target="_blank">Effects of previous infection, vaccination, and hybrid immunity against symptomatic Alpha, Beta, and Delta infections</a>
</div></li>
<li><strong>A Proposed Process for Risk Mitigation During the COVID-19 Pandemic</strong> -
<div>
Recent executive orders have led some Applied Behavior Analysis (ABA) providers to interpret themselves as “essential personnel” during the COVID-19 pandemic. In this article, we argue against a blanket interpretation that being labeled “essential personnel” means that all in person ABA services for all clients should continue during the COVID-19 pandemic. We believe this argument holds even if ABA providers are not in a jurisdiction currently under an active shelter at home or related order. First, we provide a brief description of risks associated with continued in person ABA service delivery as well as risks associated with the temporary suspension or transition to remote ABA service delivery. For many clients, continued in person service delivery carries a significant risk of severe harm to the client, their family and caregivers, the staff, and a currently overburdened healthcare system. In these situations, ABA providers should temporarily suspend services or transition to telehealth or other forms of remote service delivery until information from federal, state, and local healthcare experts deem in person contact safe. In rare cases, temporary suspension or transition to remote service delivery may place the client or others at risk of significant harm. In these situations in person services should likely continue and ongoing assessment and risk mitigation are essential.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/buetn/" target="_blank">A Proposed Process for Risk Mitigation During the COVID-19 Pandemic</a>
</div></li>
<li><strong>An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies</strong> -
<div>
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to over 760 million cases and &gt;6.8 million deaths worldwide. We developed a panel of human neutralizing monoclonal antibodies (mAbs) targeting the SARS-CoV-2 Spike protein using Harbour H2L2 transgenic mice immunized with Spike receptor binding domain (RBD) (1). Representative antibodies from genetically-distinct families were evaluated for inhibition of replication-competent VSV expressing SARS-CoV-2 Spike (rcVSV-S) in place of VSV-G. One mAb (denoted FG-10A3) inhibited infection of all rcVSV-S variants; its therapeutically-modified version, STI-9167, inhibited infection of all tested SARS-CoV-2 variants, including Omicron BA.1 and BA.2, and limited virus proliferation in vivo (1). To characterize the binding specificity and epitope of FG-10A3, we generated mAb-resistant rcVSV-S virions and performed structural analysis of the antibody/antigen complex using cryo-EM. FG-10A3/STI-9167 is a Class 1 antibody that prevents Spike-ACE2 binding by engaging a region within the Spike receptor binding motif (RBM). Sequencing of mAb-resistant rcVSV-S virions identified F486 as a critical residue for mAb neutralization, with structural analysis revealing that both the variable heavy and light chains of STI-9167 bound the disulfide-stabilized 470-490 loop at the Spike RBD tip. Interestingly, substitutions at position 486 were later observed in emerging variants of concern BA.2.75.2 and XBB. This work provides a predictive modeling strategy to define the neutralizing capacity and limitations of mAb therapeutics against emerging SARS-CoV-2 variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.04.20.537738v1" target="_blank">An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies</a>
</div></li>
<li><strong>Assessing the accuracy of California county level COVID-19 hospitalization forecasts to inform public policy decision making</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The COVID-19 pandemic has highlighted the role of infectious disease forecasting in informing public policy. However, significant barriers remain for effectively linking infectious disease forecasts to public health decision making, including a lack of model validation. Forecasting model performance and accuracy should be evaluated retrospectively to understand under which conditions models were reliable and could be improved in the future. Methods: Using archived forecasts from the California Department of Public Health9s California COVID Assessment Tool (https://calcat.covid19.ca.gov/cacovidmodels/), we compared how well different forecasting models predicted COVID-19 hospitalization census across California counties and regions during periods of Alpha, Delta, and Omicron variant predominance. Results: Based on mean absolute error estimates, forecasting models had variable performance across counties and through time. When accounting for model availability across counties and dates, some individual models performed consistently better than the ensemble model, but model rankings still differed across counties. Local transmission trends, variant prevalence, and county population size were informative predictors for determining which model performed best for a given county based on a random forest classification analysis. Overall, the ensemble model performed worse in less populous counties, in part because of fewer model contributors in these locations. Conclusions: Ensemble model predictions could be improved by incorporating geographic heterogeneity in model coverage and performance. Consistency in model reporting and improved model validation can strengthen the role of infectious disease forecasting in real-time public health decision making.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.11.08.22282086v2" target="_blank">Assessing the accuracy of California county level COVID-19 hospitalization forecasts to inform public policy decision making</a>
</div></li>
<li><strong>Evaluation of coronavirus decay in French coastal water and application to SARS-CoV-2 risk evaluation using Porcine Epidemic Diarrhea Virus as surrogate.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
SARS-CoV-2 in infected patient mainly display pulmonary and oronasal tropism however, the presence of the virus has also been demonstrated in stools of patients and consequently in wastewater treatment plant effluents, questioning the potential risk of environmental contamination (such as seawater contamination) through inadequately treated wastewater spill-over into surface or coastal waters. The environmental detection of RNA alone does not substantiate risk of infection, and evidence of an effective transmission is not clear where empirical observations are lacking. Therefore, here, we decided to experimentally evaluate the persistence and infectious capacity of the Porcine epidemic diarrhea virus (PEDv), considered as a coronavirus representative model and SARS-CoV-2 surrogate, in the coastal environment of France. Coastal seawater was collected, sterile-filtered, and inoculated with PEDv before incubation for 0–4 weeks at four temperatures representative of those measured along the French coasts throughout the year (4, 8, 15, and 24°C). The decay rate of PEDv was determined using mathematical modeling and was then used to determine the half-life of the virus along the French coast in accordance with temperatures from 2000 to 2021. We experimentally observed an inverse correlation between seawater temperature and the persistence of infectious viruses in seawater and confirm that the risk of transmission of infectious viruses from contaminated stool in wastewater to seawater during recreational practices is very limited. The present work represents a good model to assess the risk of transmission of not only SARS-CoV-2 but may also be used to model the risk of other coronaviruses, specifically enteric coronaviruses.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.04.18.23288060v1" target="_blank">Evaluation of coronavirus decay in French coastal water and application to SARS-CoV-2 risk evaluation using Porcine Epidemic Diarrhea Virus as surrogate.</a>
</div></li>
<li><strong>Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19</strong> -
<div>
Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and is influenced by host genetics. To understand mechanisms of inflammation, animal models that reflect genetic diversity and clinical outcomes observed in humans are needed. We report a mouse panel comprising the genetically diverse Collaborative Cross (CC) founder strains crossed to human ACE2 transgenic mice (K18-hACE2) that confers susceptibility to SARS-CoV-2. Infection of CC x K18- hACE2 resulted in a spectrum of survival, viral replication kinetics, and immune profiles. Importantly, in contrast to the K18-hACE2 model, early type I interferon (IFN-I) and regulated proinflammatory responses were required for control of SARS-CoV-2 replication in PWK x K18-hACE2 mice that were highly resistant to disease. Thus, virus dynamics and inflammation observed in COVID-19 can be modeled in diverse mouse strains that provide a genetically tractable platform for understanding anti-coronavirus immunity.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.09.17.460664v3" target="_blank">Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19</a>
</div></li>
<li><strong>Optimality of Maximal-Effort Vaccination</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It is widely acknowledged that vaccinating at maximal effort in the face of an ongoing epidemic is the best strategy to minimise infections and deaths from the disease. Despite this, no one has proved that this is guaranteed to be true if the disease follows multi-group SIR (Susceptible-Infected-Recovered) dynamics. This paper provides a novel proof of this principle for the existing SIR framework, showing that the total number of deaths or infections from an epidemic is decreasing in vaccination effort. Furthermore, it presents a novel model for vaccination which assumes that vaccines are distributed randomly to the unvaccinated population and suggests, using COVID-19 data, that this more accurately captures vaccination dynamics than the model commonly found in the literature. However, as the novel model provides a strictly larger set of possible vaccination policies, the results presented in this paper hold for both models.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.05.12.22275015v3" target="_blank">Optimality of Maximal-Effort Vaccination</a>
</div></li>
<li><strong>Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity</strong> -
<div>
Human coronaviruses (HCoVs) cause respiratory tract infections and are of great importance due to the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Human betacoronavirus OC43 (HCoV-OC43) is an adequate surrogate for SARS-CoV-2 because it infects the human respiratory system, presents a comparable biology, and is transmitted in a similar way. Its use is advantageous since it only requires biosafety level (BSL)-2 infrastructure which minimizes costs and biosafety associated limitations. In this report, we describe a high-throughput screening (HTS) platform to identify compounds that inhibit the propagation of HCoV-OC43. Optimization of assays based on inhibition of the cytopathic effect and virus immunodetection with a specific antibody, has provided a robust methodology for the screening of a selection of microbial natural product extracts from the Fundacion MEDINA collection. Using this approach, a subset of 1280 extracts has been explored. Of these, upon hit confirmation and early LC-MS dereplication, 10 extracts were identified that contain potential new compounds. In addition, we report on the novel antiviral activity of some previously described natural products whose presence in bioactive extracts was confirmed by LC/MS analysis.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.04.20.537680v1" target="_blank">Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity</a>
</div></li>
<li><strong>Overburdened Bureaucrats: Providing Equal Access to Public Services during COVID-19</strong> -
<div>
Discriminatory treatment of minorities by bureaucrats remains a serious challenge. A dominant explanation argues that bureaucrats discriminate because of high workloads in public organizations, but few empirical studies test this outside of the lab. In this study, I investigate whether workload matters for discrimination in a real-world public service context during the COVID-19 pandemic in Denmark in 2020. I document that unemployment services experienced a substantial increase in workload due to a 20% rise in unemployment and exploit the fact that the increase happened suddenly and spread asymmetrically. I use micro-level register data on bureaucrat-client interactions on more than 380,000 unemployed and examine whether bureaucrats provided fewer services to citizens of non-Western descent. The finding reveals that the substantial workload associated with the COVID-19 pandemic did not lead to increased discrimination. I discuss the special circumstances associated with the COVID-19 pandemic and the possible role of organizational structure and professional norms.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/zmt5y/" target="_blank">Overburdened Bureaucrats: Providing Equal Access to Public Services during COVID-19</a>
</div></li>
<li><strong>Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science</strong> -
<div>
Biopsy is crucial in clinical medicine to obtain tissues and cells that may directly reflect the pathological changes of each disease. However, the brain is an exception due to ethical and practical challenges. Nasal biopsy, which captures olfactory neurons and their progenitors, has been considered as an alternative method of obtaining neuronal cells from living patients. Multiple groups, including us, have enriched olfactory neuronal cells (ONCs) from nasal biopsied tissue. ONCs can be obtained from repeated biopsies in a longitudinal study, providing mechanistic insight associated with dynamic changes along the disease trajectory and treatment response. Nevertheless, molecular characterization of nasal biopsied cells/tissue has been insufficient. Taking advantage of recent advances in next-generation sequencing technologies at the single-cell resolution and related rich public databases, we aimed to define the neuronal characteristics of ONCs, their homogeneity, and their utility. We conducted single-cell and bulk RNA sequencing, analyzed and compared the data with multiple public datasets. We observed that the molecular signatures of ONCs are similar to those of neurons, distinct from major glial cells. The signatures of ONCs resemble those of developing neurons and share features of excitatory neurons in the prefrontal and cingulate cortex. The high homogeneity of ONCs is advantageous in pharmacological, functional, and protein studies. Together, the present data solidify the utility of ONCs in studying molecular mechanisms and exploring objective biomarkers for brain disorders. The ONCs may also be useful in studying the potential link between the olfactory epithelium impairment and the resultant mental dysfunction elicited by SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.23.509290v2" target="_blank">Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science</a>
</div></li>
<li><strong>Machine learning detection of SARS-CoV-2 high-risk variants</strong> -
<div>
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved many high-risk variants, resulting in repeated COVID-19 waves of pandemic during the past years. Therefore, accurate early-warning of high-risk variants is vital for epidemic prevention and control. Here we construct a machine learning model to predict high-risk variants of SARS-CoV-2 by LightGBM algorithm based on several important haplotype network features. As demonstrated on a series of different retrospective testing datasets, our model achieves accurate prediction of all variants of concern (VOC) and most variants of interest (AUC=0.96). Prediction based on the latest sequences shows that the newly emerging lineage BA.5 has the highest risk score and spreads rapidly to become a major epidemic lineage in multiple countries, suggesting that BA.5 bears great potential to be a VOC. In sum, our machine learning model is capable to early predict high-risk variants soon after their emergence, thus greatly improving public health preparedness against the evolving virus.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.04.19.537460v1" target="_blank">Machine learning detection of SARS-CoV-2 high-risk variants</a>
</div></li>
<li><strong>Mobilisation and analyses of publicly available SARS-CoV-2 data for pandemic responses</strong> -
<div>
The COVID-19 pandemic has seen large-scale pathogen genomic sequencing efforts, becoming part of the toolbox for surveillance and epidemic research. This resulted in an unprecedented level of data sharing to open repositories, which has actively supported the identification of SARS-CoV-2 structure, molecular interactions, mutations and variants, and facilitated vaccine development and drug reuse studies and design. The European COVID-19 Data Platform was launched to support this data sharing, and has resulted in the deposition of several million SARS-CoV-2 raw reads. In this paper we describe (1) open data sharing, (2) tools for submission, analysis, visualisation and data claiming (e.g. ORCiD), (3) the systematic analysis of these datasets, at scale via the SARS-CoV-2 Data Hubs as well as (4) lessons learned. As a component of the Platform, the SARS-CoV-2 Data Hubs enabled the extension and set up of infrastructure that we intend to use more widely in the future for pathogen surveillance and pandemic preparedness.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.04.19.537514v1" target="_blank">Mobilisation and analyses of publicly available SARS-CoV-2 data for pandemic responses</a>
</div></li>
<li><strong>SARS-CoV-2 utilization of ACE2 from different bat species allows for virus entry and replication in vitro</strong> -
<div>
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is believed to have a zoonotic origin. Bats are a suspected natural host of SARS-CoV-2 because of sequence homology with other bat coronaviruses. Understanding the origin of the virus and determining species susceptibility is essential for managing the transmission potential during a pandemic. In a previous study, we established an in vitro animal model of SARS-CoV-2 susceptibility and replication in a non-permissive avian fibroblast cell line (DF1) based on expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) from different animal species. In this work, we express the ACE2 of seven bat species in DF1 cells and determine their ability to support attachment and replication of the original SARS-CoV-2 Wuhan lineage virus, as well as two variants, Delta and Lambda. We demonstrate that the ACE2 receptor of all seven species: little brown bat (Myotis lucifugus), great roundleaf bat (Hipposideros armiger), Pearson’s horseshoe bat (Rhinolophus pearsonii), greater horseshoe bat (Rhinolophus ferrumequinum), Brazilian free-tailed bat (Tadarida brasiliensis), Egyptian rousette (Rousettus aegyptiacus), and Chinese rufous horseshoe bat (Rhinolophus sinicus), made the DF1 cells permissible to the three isolates of SARS-CoV-2. However, the level of virus replication differed between bat species and variant tested. In addition, the Wuhan lineage SARS-CoV-2 virus replicated to higher titers (104.5 -105.5 TCID50) than either variant virus (103.5-104.5 TCID50) on pass 1. Interestingly, all viruses tested grew to higher titers (approximately 106 TCID50) when cells expressed the human ACE2 gene compared to bat ACE2. This study provides a practical in vitro method for further testing of animal species for potential susceptibility to current and emerging SARS-CoV-2 viruses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.04.19.537521v1" target="_blank">SARS-CoV-2 utilization of ACE2 from different bat species allows for virus entry and replication in vitro</a>
</div></li>
<li><strong>A rapid review of the effectiveness, efficiency, and acceptability of surgical hubs in supporting planned care activity</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The COVID-19 pandemic further exacerbated disruptions to elective care services in the UK, leading to longer waits for treatment and a growing elective surgery backlog. There have been growing calls for the creation of surgical hubs to help reduce this backlog. Surgical hubs aim to increase surgical capacity by providing quicker access to procedures, as well as facilitate infection control by segregating patients and staff from emergency care. This rapid review aimed to assess the effectiveness, efficiency, and acceptability of surgical hubs in supporting planned care activity, to inform the implementation of these hubs in Wales. The review identified evidence available up until January 2023. Twelve primary studies were included, eight of which used comparative methods. Most of the studies were conducted during the COVID-19 pandemic and described surgical hubs designed mainly to mitigate the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Outcome measures reported included clinical, performance, economic, and patient reported outcomes across a variety of different surgical disciplines. Most of the studies did not describe surgical hubs based on their structure, i.e., standalone, integrated, or ring-fenced hubs. The evidence relating to the impact of surgical hubs on clinical outcomes appeared to be heterogenous and limited. Included studies did not appear to control for the impact of the COVID-19 pandemic on outcomes. Evidence of the impact of surgical hubs on performance outcomes such as efficiency, utilisation/usage, volume of surgeries/treatments, performance, cancellations, and time from diagnosis to treatment is limited. Evidence relating to the economic impact of surgical hubs is also limited, however there is evidence to suggest that total average costs are lower in surgical hubs when compared to general hospitals. Evidence relating to the impact of surgical hubs on patient reported outcomes is limited but indicates there may be a positive effect on patient satisfaction and compliance. Considerable variation in the types of surgical hubs reviewed, surgical disciplines, along with the small number of comparative studies, as well as methodological limitations across included studies, could limit the applicability of these findings.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.04.20.23288815v1" target="_blank">A rapid review of the effectiveness, efficiency, and acceptability of surgical hubs in supporting planned care activity</a>
</div></li>
<li><strong>Mortality among persons with HIV in the United States during the COVID-19 pandemic: a population-level analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Whether COVID-19 has had a disproportionate impact on mortality among persons with diagnosed HIV (PWDH) in United States is unclear. Through our macro-scale analysis, we seek to better understand how COVID-19 and subsequent behavioral changes affected mortality among PWDH. Methods: We obtained mortality and population size data for the years 2018-2020 from the National HIV Surveillance System (NHSS) for the PWDH population aged ≥13 years in the United States, and from publicly available data for the general population. We computed mortality rates and excess mortality for both the general and PWDH populations. Stratifications by age, race/ethnicity, and sex-at birth were considered. For each group, we determined whether the 2020 mortality rates and mortality risk ratio showed a statistically significant change from 2018-2019. Results: Mortality rates increased in 2020 from 2018-2019 across the general population in all groups. Among PWDH, mortality rates either increased, or showed no statistically significant change. The mortality risk ratio between PWDH and the general population decreased 7.7% in 2020. Approximately 1550 excess deaths occurred among PWDH in 2020, with Black, Hispanic/Latino and PWDH above 55 and older representing the majority of excess deaths. Conclusions: While mortality rates among PWDH increased in 2020 relative to 2018-2019, the increases were smaller than those observed in the general population. This suggests that COVID-19 and resulting behavioral changes among PWDH did not result in disproportionate mortality among PWDH. These findings suggest that COVID-19, and any associated indirect effects, do not represent a proportionally greater risk for PWDH compared to the general population.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.04.19.23288817v1" target="_blank">Mortality among persons with HIV in the United States during the COVID-19 pandemic: a population-level analysis</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effectiveness and Safety of Quinine Sulfate as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia ( DEAL-COVID19 )</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Standard of Care + Quinine Sulfate;   Drug: Standard of Care<br/><b>Sponsors</b>:   Universitas Padjadjaran;   National Research and Innovation Agency of Indonesia;   Prodia Diacro Laboratories P.T.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19</strong> - <b>Condition</b>:   Long COVID-19 Syndrome<br/><b>Intervention</b>:   Biological: MSC-derived exosomes<br/><b>Sponsors</b>:   Huazhong University of Science and Technology;   REGEN-αGEEK (SHENZHEN) MEDICAL TECHNOLOGY CO., LTD.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Nirmatrelvir/Ritonavir for Treating Omicron Variant of COVID-19</strong> - <b>Condition</b>:   Omicron Variant of COVID-19<br/><b>Intervention</b>:   Drug: Nirmatrelvir/Ritonavir<br/><b>Sponsor</b>:   Xiangao Jiang<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study of mRNA-1283.222 Injection Compared With mRNA-1273.222 Injection in Participants ≥12 Years of Age to Prevent COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: mRNA-1283.222;   Biological: mRNA-1273.222<br/><b>Sponsor</b>:   ModernaTX, Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>To Evaluate the Safety and Efficacy of Meplazumab in Treatment of COVID-19 Sequelae</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Meplazumab for injection;   Other: Normal saline<br/><b>Sponsor</b>:   Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the RD-X19 Treatment Device in Individuals With Mild COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Device: RD-X19;   Device: Sham<br/><b>Sponsor</b>:   EmitBio Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Study for the Efficacy and Safety of Ropeginterferon Alfa-2b in Adult COVID-19 Patients With Comorbidities</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Ropeginterferon alfa-2b;   Procedure: SOC<br/><b>Sponsor</b>:   National Taiwan University Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Assessment of Immunogenicity, Safety and Reactogenicity of a Booster Dose of Various COVID-19 Vaccine Platforms in Individuals Primed With Several Regimes.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: SCB-2019/Clover;   Biological: AstraZeneca/Fiocruz;   Biological: Pfizer/Wyeth<br/><b>Sponsors</b>:   D’Or Institute for Research and Education;   Bill and Melinda Gates Foundation<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Postoperative Sugammadex After COVID-19</strong> - <b>Conditions</b>:   General Anesthesia;   COVID-19<br/><b>Interventions</b>:   Drug: Sugammadex Sodium;   Drug: neostigmine 50µg/kg + glycopyrollate 0.01mg/kg<br/><b>Sponsor</b>:   Korea University Ansan Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Azeliragon;   Drug: Placebo<br/><b>Sponsor</b>:   Salim S. Hayek<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cognitive-behavioral Therapy for Mental Disorder in COVID-19 Survivors</strong> - <b>Condition</b>:   Post Acute COVID-19 Syndrome<br/><b>Intervention</b>:   Behavioral: mindfulness-based stress reduction (MBSR) and cognitive behavioral therapy (CBT)<br/><b>Sponsor</b>:   Azienda Socio Sanitaria Territoriale di Lecco<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Lactobacillus Paracasei PS23 for Patients With Post-COVID-19 Syndrome</strong> - <b>Condition</b>:   Post-COVID-19 Syndrome<br/><b>Intervention</b>:   Dietary Supplement: PS23 heat-treated<br/><b>Sponsors</b>:   Mackay Memorial Hospital;   Bened Biomedical Co., Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring the Effect of Video Interventions on Intentions for Continued COVID-19 Vaccination</strong> - <b>Conditions</b>:   Vaccine Refusal;   COVID-19<br/><b>Interventions</b>:   Behavioral: Informational Video;   Behavioral: Altruistic Video;   Behavioral: Individualistic Video<br/><b>Sponsor</b>:   Sir Mortimer B. Davis - Jewish General Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Telerehabilitation Practice in Long COVID-19 Patients</strong> - <b>Conditions</b>:   Long COVID-19;   Long COVID;   Post COVID-19 Condition;   Post-COVID-19 Syndrome;   Post-COVID Syndrome<br/><b>Interventions</b>:   Behavioral: Telerehabilitation;   Behavioral: Standard rehabilitation care<br/><b>Sponsor</b>:   Indonesia University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rehabilitation Treatment of Patients With COVID-19</strong> - <b>Conditions</b>:   Rehabilitation;   Pneumonia, Viral;   COVID-19;   Quality of Life<br/><b>Interventions</b>:   Other: exercises;   Other: massage<br/><b>Sponsors</b>:   I.M. Sechenov First Moscow State Medical University;   MEDSI Clinical Hospital 1, ICU<br/><b>Completed</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiviral activities of hemp cannabinoids</strong> - Hemp is an understudied source of pharmacologically active compounds and many unique plant secondary metabolites including more than 100 cannabinoids. After years of legal restriction, research on hemp has recently demonstrated antiviral activities in silico, in vitro, and in vivo for cannabidiol (CBD), Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), and several other cannabinoids against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prospecting native and analogous peptides with anti-SARS-CoV-2 potential derived from the trypsin inhibitor purified from tamarind seeds</strong> - The study aimed to prospect in silico native and analogous peptides with anti-SARS-CoV-2 potential derived from the trypsin inhibitor purified from tamarind seeds (TTIp). From the most stable theoretical model of TTIp (TTIp 56/287), in silico cleavage was performed for the theoretical identification of native peptides and generation of analogous peptides. The anti-SARS-CoV-2 potential was investigated through molecular dynamics (MD) simulation between the peptides and binding sites of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19</strong> - Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms of response to viral infection in experimental in vivo rhinovirus infection in healthy controls and patients with asthma, and in in vitro experiments with house dust mite, rhinovirus and SARS-CoV-2 in human primary…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with Granulomatosis with polyangiitis</strong> - CONCLUSIONS: Modulation of cellular effector function by ShK-186 may constitute a novel treatment strategy for GPA with high specificity and less harmful side effects.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kinetics and ability of binding antibody and surrogate virus neutralization tests to predict neutralizing antibodies against the SARS-CoV-2 Omicron variant following BNT162b2 booster administration</strong> - CONCLUSIONS: This study showed a significant drop in humoral immunity 6 months after booster administration. Anti-RBD IgG and Omicron sVNT assays were highly correlated and could predict neutralizing activity with moderate performance.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8</strong> - CONCLUSIONS: Taken together, our work shows that host MHC molecules play a crucial role in the pathogenicity differences of SARS-CoV-2/BMA8 infection. This provides a more profound insight into the pathogenesis of SARS-CoV-2, and contributes enlightenment and guidance for controlling the virus spread.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase</strong> - Monkeypox is a disease with pandemic potential. It is caused by the monkeypox virus (MPXV), a double-stranded DNA virus from the Poxviridae family, that replicates in the cytoplasm and must encode for its own RNA processing machinery including the capping machinery. Here, we present crystal structures of its 2’-O-RNA methyltransferase (MTase) VP39 in complex with the pan-MTase inhibitor sinefungin and a series of inhibitors that were discovered based on it. A comparison of this 2’-O-RNA MTase…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synthesis of SARS-CoV-2 M<sup>pro</sup> inhibitors bearing a cinnamic ester warhead with <em>in vitro</em> activity against human coronaviruses</strong> - COVID-19 now ranks among the most devastating global pandemics in history. The causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among humans and animals. Great efforts have been made to develop therapeutic agents to treat COVID-19, and among the available viral molecular targets, the cysteine protease SARS-CoV-2 M^(pro) is considered the most appealing one due to its essential role in viral replication. However, the inhibition of M^(pro) activity is an interesting…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Diosmetin alleviates acute lung injury caused by lipopolysaccharide by targeting barrier function</strong> - Acute lung injury (ALI) is an acute and devastating disease caused by systemic inflammation e.g. patients infected with bacteria and viruses such as SARS-CoV-2 have an unacceptably high mortality rate. It has been well documented that endothelial cell damage and repair play a central role in the pathogenesis of ALI because of its barrier function. Nevertheless, the leading compounds that effectively accelerate endothelial cell repair and improve barrier dysfunction in ALI are largely unknown. In…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Networking Accelerated Discovery of Biflavonoid Alkaloids from Cephalotaxus sinensis</strong> - Four undescribed biflavonoid alkaloids, sinenbiflavones A-D, were isolated from Cephalotaxus sinensis using a MS/MS-based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HRESIMS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A-D are the first examples of amentoflavone-type (C-3’-C-8’’) biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C-6-methylated amentoflavone-type biflavonoid alkaloids. Sinenbiflavone D showed weak…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Integrin β1 is a key determinant of the expression of angiotensin-converting enzyme 2 (ACE2) in the kidney epithelial cells</strong> - The expression of the angiotensin-converting enzyme 2 (ACE2) is altered in multiple chronic kidney diseases like hypertension and renal fibrosis, where the signaling from the basal membrane proteins is critical for the development and progression of the various pathologies. Integrins are heterodimeric cell surface receptors that have important roles in the progression of these chronic kidney diseases by altering various cell signaling pathways in response to changes in the basement membrane…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results</strong> - CONCLUSIONS: AZD4831 inhibited myeloperoxidase and was well tolerated in patients with HF and LVEF ≥40%. Efficacy findings were exploratory due to early termination but warrant further clinical investigation of AZD4831.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Awareness raising and dealing with methanol poisoning based on effective strategies</strong> - Intoxication with methanol most commonly occurs as a consequence of ingesting, inhaling, or coming into contact with formulations that include methanol as a base. Clinical manifestations of methanol poisoning include suppression of the central nervous system, gastrointestinal symptoms, and decompensated metabolic acidosis, which is associated with impaired vision and either early or late blindness within 0.5-4 h after ingestion. After ingestion, methanol concentrations in the blood that are…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ferrocenoyl-substituted quinolinone and coumarin as organometallic inhibitors of SARS-CoV-2 3CLpro main protease</strong> - The 3-chymotrypsin-like protease 3CLpro from SARS-CoV-2 is a potential target for antiviral drug development. In this work, three organometallic ferrocene-modified quinolinones and coumarins were compared to their benzoic acid ester analogues with regard to inhibition of 3CLpro using a HPLC-based assay with a 15mer model peptide as the substrate. In contrast to FRET-based assays, this allows direct identification of interference of buffer constituents with the inhibitors, as demonstrated by the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Transcription factor <em>Dmrt1</em> triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility</strong> - Bacterial or viral infections, such as Brucella, mumps virus, herpes simplex virus, and Zika virus, destroy immune homeostasis of the testes, leading to spermatogenesis disorder and infertility. Of note, recent research shows that SARS-CoV-2 can infect male gonads and destroy Sertoli and Leydig cells, leading to male reproductive dysfunction. Due to the many side effects associated with antibiotic therapy, finding alternative treatments for inflammatory injury remains critical. Here, we found…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<script>AOS.init();</script></body></html>

424
archive-daily-dose/23 April, 2023.html Normal file
View File

@ -0,0 +1,424 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>23 April, 2023</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
ul.task-list{list-style: none;}
</style>
<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Has Black Lives Matter Changed the World?</strong> - A new book makes the case for a more pragmatic anti-policing movement—one that seeks to build working-class solidarity across racial lines. - <a href="https://www.newyorker.com/news/our-columnists/has-black-lives-matter-changed-the-world">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fox News Doesn’t Do Apologies</strong> - Rupert Murdoch may have to pay for Donald Trump’s 2020 election lies, but who’s going to reimburse American democracy? - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/fox-news-doesnt-do-apologies">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clarence Thomas’s Friend of the Court</strong> - Thomas claims that Harlan Crow’s extravagant gifts were tokens of friendship. Why do the Justices so often emphasize personal relationships? - <a href="https://www.newyorker.com/news/our-columnists/clarence-thomass-friend-of-the-court">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>It’s Earth Day—and the News Isn’t Good</strong> - New reports show that ice sheets in Greenland and Antarctica are melting faster than anticipated, and other disasters loom. - <a href="https://www.newyorker.com/news/daily-comment/its-earth-day-and-the-news-isnt-good">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Gospel of Candace Owens</strong> - The Daily Wire host is waging a far-right fight for the soul of pop culture. - <a href="https://www.newyorker.com/news/annals-of-communications/the-gospel-of-candace-owens">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Why are you crying?</strong> -
<figure>
<img alt="A pop art illustration of blue eyes with long eyelashes overflowing with tears. " src="https://cdn.vox-cdn.com/thumbor/D6KrHDJuNXmqiGdQ_Om8vXwkqpo=/278x0:4722x3333/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72208270/GettyImages_1226462891.0.jpg"/>
<figcaption>
Getty Images/iStockphoto
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Consider where, when, and around whom you cry.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KFW6WC">
Here is a non-exhaustive list of things that have made me cry: Any time I must <a href="https://www.vox.com/even-better/23436672/how-to-start-cooking-beginner-guide">chop, dice, or mince</a> ingredients; a group of sea lions barking in the sun; sad music; receiving a free hot dog; the film <em>500 Days of Summer</em>; a messy house.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JnPZ8D">
The one emotion tying all of these experiences together, according to <a href="http://www.advingerhoets.com/">Ad Vingerhoets</a>, an emeritus professor at Tilburg University and one of the world’s preeminent experts on crying, is a sense of powerlessness. Even in the context of positive tear-jerking events — like encountering a very small puppy or watching your best friend walk down the aisle at their wedding — there is a feeling of overwhelm, Vingerhoets says. “You also feel small and helpless and humble,” he says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nr5vUp">
Humans come into the world crying, and we never really stop. As babies, we <a href="https://www.youtube.com/watch?v=1XOo1OJFAeQ">cry in order to get attention from our parents</a>, signaling to them that we’re <a href="https://www.sciencedaily.com/releases/2013/02/130219090649.htm">angry or scared or in pain</a> or hungry or tired. In childhood and adolescence, we cry from physical pain, like a scraped knee, but as we <a href="https://pure.uvt.nl/ws/portalfiles/portal/473666/crying.pdf">develop empathy</a> in our teenage years, external catalysts — like books, movies, and other people’s pain — elicit tears. As we get older, we may be moved to tears by beauty, awe, wonder, and sentimentality, says <a href="https://www.psychiatry.pitt.edu/about-us/our-people/faculty/lauren-m-bylsma-phd">Lauren Bylsma</a>, an associate professor of psychiatry and psychology at the University of Pittsburgh.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ttews2">
For some people, the well of tears has run dry. The stereotype that <a href="https://www.nytimes.com/2020/05/03/us/politics/crying-politicians-leadership.html">criers are seen as weaker or less masculine</a> contributes to the well-trodden notion that <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795704/">boys (and men) don’t cry</a>. Indeed, <a href="https://www.researchgate.net/publication/235660812_Country_and_crying_Prevalences_and_gender_differences">women report crying </a>more frequently than men and with shorter gaps in between crying episodes than men. Then, there’s that thorny feeling of vulnerability associated with sobbing; to betray the veneer of stoicism is deeply uncomfortable for some, to admit you need help can be seen as a failure.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="afLWzY">
But have you ever stopped to consider why you’re crying? The root cause of the sadness or overwhelm? What about what you can learn from your tears? Mining the depths of your emotions can shed light on deeper insecurities, fears, pleasures, and relationship complications.
</p>
<h3 id="e4PzUk">
What our tears tell us
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wNi3CV">
The presence of tears signals one basic message, says <a href="https://www.vassar.edu/faculty/corney">Randolph Cornelius</a>, a professor of psychological science at Vassar College: I need help. “We’re asking other people to aid us,” he says. Research suggests tears are so effective at eliciting help because <a href="https://link.springer.com/article/10.1007/s11031-016-9543-0">criers are seen as sadder</a>, more helpless, less aggressive, and in need of interpersonal connection. According to one of Vingerhoets’ <a href="https://pubmed.ncbi.nlm.nih.gov/27709633/">2017 studies</a>, people are more likely to offer help to a crying person compared to just a sad person with a dry face. “Recognizing that people [are] crying and in need of help is a pretty automatic process,” Cornelius says.
</p>
<div id="v3lfBN">
<div class="volume-video" id="volume-placement-673">
</div></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aJFVQr">
Throughout the entire lifespan, some of the most common triggers of tears, Vingerhoets says, are bereavement, heartache, and homesickness. (Though <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795704/">women do cry more often</a> in general over more mundane and conflict-driven situations, “the difference between the sexes is not that big” when it comes to these main motivators of crying, Vingerhoets says.) Then there are the positive cries: Weeping not just over a separation, but a reunion; crying out of relief and not fear; shedding tears when receiving a gift, not only when having it taken away. “All of these negative situations that provoked tears, they all seem to have their opposite,” Vingerhoets says, “which also induces tears.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="22Q7Dn">
We receive the most support when we cry in front of a partner or a friend, Bylsma says, someone who is best equipped to <a href="https://www.vox.com/even-better/23589570/offer-help-support-validation">console and emotionally support </a>us. Research shows that the presence of visible tears can also bring <a href="https://www.sciencedaily.com/releases/2009/08/090824141045.htm">people closer together</a> and <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882350/">promote social bonding</a>. “If you are stressed, it’s important that you receive social support from others,” Vingerhoets says, “because that can buffer the negative effects of stress on your well-being.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JWyPjc">
Subliminally or not, we may realize that turning on the waterworks gets us what we want. “I have a 10-year-old grandson and he can turn crying on and off,” Cornelius says. “Kids learn how to manipulate adults and so that stays with us.” Much has been written about the weaponization of tears, <a href="https://journals.sagepub.com/doi/full/10.1177/1367549420985852">especially</a> <a href="https://journals.sagepub.com/doi/full/10.1177/1367549420985852">by white</a> <a href="https://www.theguardian.com/commentisfree/2018/may/08/how-white-women-use-strategic-tears-to-avoid-accountability">women</a>, in order to protect privilege and garner sympathy. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040244/">Research finds</a> that fake criers are seen as manipulative, less reliable, less warm, less competent, and less accepted as friends, colleagues, or neighbors. But usually, Cornelius says, adults keep their tears in check, having learned the socially appropriate places to cry (in private, on the side of the road when you have a flat tire) and opting not to cry at our desks at work when we feel frustrated. That is, unless the situation is uniquely overwhelming, Cornelius says, like in the face of an unexpected tragedy.
</p>
<h3 id="9BJeYt">
Why the context of the cry matters
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Al22UY">
Popular convention maintains that crying is a cathartic experience, that we feel cleansed and weightless following a good weep. “That’s not always the case,” Bylsma says, “and it really depends on various contextual factors.” We’re likely to reap the most benefit from crying if we can shed a few tears in a safe place, Bylsma says. “We found in research if someone were to cry in a place where it might be embarrassing, where people might react in a negative way, like crying in front of people you don’t know well in a workplace setting, for example, someone’s going to feel worse after crying,” she says, “versus if you cry in a more supportive environment, like in front of a partner or friend that you’re more likely to have a benefit from.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FEjYZs">
In <a href="https://citeseerx.ist.psu.edu/document?repid=rep1&amp;type=pdf&amp;doi=7ae5449693efc042cfab49d4ffcf2c0721b7f036">one of Vingerhoets’ and Bylsma’s studies</a>, they found that people who are depressed, anxious, or experiencing burnout cry more, but they <a href="https://megaphone.link/VMP7338729775">did not feel relief after crying</a>. Those who felt shame and embarrassment were less likely to feel better following a cry, too. People find more catharsis after crying when the situation that made them weepy was controllable — like a fight with their partner — as opposed to an uncontrollable event, like a death.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AUfmfo">
Bylsma also notes that chronically suppressing tears is associated with negative emotional effects, <a href="https://pubmed.ncbi.nlm.nih.gov/28831948/">like less empathy and emotional support</a>, based on surveys. So if you feel the need to cry in the middle of a work meeting, try to get yourself to a bathroom and let it out. On the contrary, for those who have no reason to cry and forgo weeping for a long time, even years, there’s no harm in that, Vingerhoets says. However, persistent bouts of crying and ruminating over the same issues might be a sign you need to change your approach to crying, Bylsma says. Try seeking the help of a therapist or mental health professional who can help you cope.
</p>
<h3 id="0y05VD">
What crying reveals
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b4bUPT">
Regardless of what made you cry, whether it be a sad movie or a beautiful sunset, there is a deeper meaning. The presence of tears reveals what matters to you. “Sometimes our tears are signals to ourselves about the significance of events,” Cornelius says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6iriS3">
Consider the last time you cried. Was it an argument? An exhausting day? A delicious cupcake? What about those situations stirred up emotions? In the moment of the crying episode, try to process what, exactly, is making you cry, Cornelius says. “We do have an inner drive to know ourselves,” he says. “I think recognizing our emotions, giving them their due, allows us to do that.” Over time, you may recognize patterns in your emotions: I feel resentful in these situations, those comments make me feel embarrassed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ktgLtz">
Having this bit of insight can help you reframe the situation: This isn’t an argument about taking out the trash, it’s an argument about respect. Sometimes tears can help reveal these underlying messages.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gl3BY2">
“When you have a realization about yourself, and that allows you to see yourself in a different way, you do feel empowered,” Cornelius says.
</p>
<ul>
<li><strong>Where are all the apartments for families?</strong> -
<figure>
<img alt="The New York City skyline with pedestrians and strollers in the foreground." src="https://cdn.vox-cdn.com/thumbor/HUCYX5QkekFG0sUUDN3ytuf3OOw=/428x0:4857x3322/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72208231/629596353.0.jpg"/>
<figcaption>
Eye Ubiquitous/Universal Images Group via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Cities are finally starting to build more housing — but not for people with kids.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w9fp6z">
Roughly <a href="https://www.pewresearch.org/social-trends/2019/02/14/millennial-life-how-young-adulthood-today-compares-with-prior-generations-2/">40 percent</a> of American millennials have four-year college degrees, and if there’s one thing these highly educated young people have liked to do over the last 15 years, it’s move to big cities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6bIsxX">
Researchers find they (well, we) have accounted <a href="https://cityobservatory.org/wp-content/uploads/2020/06/Youth_Movement_CO_Report_2020.pdf">for more than half</a> the population increase in “close-in” urban neighborhoods in the country’s largest metro areas since 2010, and they credit our migration (and our taxes) with accelerating <a href="https://www.sciencedirect.com/science/article/abs/pii/S0094119020300383">urban revival</a>. We don’t have to guess as to why: Millennials like diverse, walkable environments with good public transit and bike lanes. They like the rich cultural amenities, including bars, restaurants, and concert venues. And they like the higher-paying work opportunities available.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zkiK9i">
All this might make you think millennials have moved to cities permanently. But as they get older, the number of urban children has continued to drop. Lower birth rates are part of the story, but economists say the strong correlations with population shifts strongly suggest that <a href="https://eig.org/family-exodus/">“out-migration” of cities explains a big portion of the loss</a>. In other words, millennials now in their mid-30s and 40s with young kids have started decamping for suburbs to raise their families.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XavxNG">
Some older adults nod smugly, seeing these suburban migration patterns as proof that there was <a href="https://kinder.rice.edu/urbanedge/what-if-city-loving-millennials-are-just-myth">never any meaningful difference</a> between their preferences and that of millennials at all. Millennials did not start the trend of moving to cities in one’s 20s: Plenty of baby boomers and Gen X moved to urban areas in young adulthood, and then back to the suburbs to raise a family once they coupled up and needed more space.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mXd3in">
And certainly some millennial families really do crave the kind of lifestyles found in suburbs: the bigger houses and lawns, the schools, and safety.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zP2LfR">
But for many other young people looking to start families, the choice to stay in the city or move to the suburbs doesn’t feel much like a choice at all. There simply aren’t many family-oriented housing options in cities, let alone ones young couples could afford.
</p>
<aside id="JxqALm">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nolMV4">
For years now the <a href="https://www.vox.com/policy/23595421/biden-affordable-housing-shortage-supply">shortage of housing</a>, and the <a href="https://www.vox.com/videos/2021/8/17/22628750/how-the-us-made-affordable-homes-illegal">dearth of new housing built</a> to accommodate a growing population, has been getting more attention. But only more recently <a href="https://omny.fm/shows/odd-lots/why-we-dont-build-more-apartments-for-families">have people started to discuss</a> that, even in places that have loosened their zoning rules and authorized new housing construction, the overwhelming majority of new units are studios or one- and two-bedroom apartments, built with singles, childless couples, and adult roommates in mind.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3zZBf4">
Advocates for more housing say they’re aware that cities are losing families with kids, even in areas that are adding new units to the market — and they argue that it’s one reason why reforming zoning is only the first step toward building cities that house more people.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xcnsck">
“Yes, there’s been a ‘build baby build’ attitude because we’re so far behind, but there are big asterisks and caveats to that,” said Matt Lewis, a spokesperson for California YIMBY, a pro-housing group. “If you just do zoning, you will end up with a whole lot of one- and two-bedrooms.”
</p>
<h3 id="qzNxpK">
Zoning reform is necessary but not sufficient
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PNaiuQ">
Housing demand outstrips supply in major cities, leading to rising costs for tenants and prospective homeowners. A top culprit for this scarcity is local zoning laws that bar new construction and empower homeowners who gain financially from restricting new housing to decide whether or not to make room for more neighbors.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cZ8tzE">
Over the last decade, there has been a growing movement to loosen zoning rules to facilitate more construction. And among those few places that have changed their zoning laws, <a href="https://www.lewis.ucla.edu/research/market-rate-development-impacts/">evidence suggests</a> it has <a href="https://www.pewtrusts.org/en/research-and-analysis/articles/2023/04/17/more-flexible-zoning-helps-contain-rising-rents">helped contain rising rents</a>, largely by reducing competition among individuals for units.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AmTdNE">
Addressing restrictive zoning is a crucial first step to making cities more affordable, and most communities still haven’t even taken that step.
</p>
<aside id="9nzoD1">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nPmCxQ">
Orphe Divounguy, a senior economist at Zillow, analyzed the top metropolitan areas sourced from the American Community Survey and found that the most “doubling up” — meaning a family living with another family — occurs in the nation’s most expensive cities, like Los Angeles, Boston, Denver, Seattle, and Washington, DC.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FrzSjw">
While some might simply prefer these living arrangements, Divounguy observed that nearly 70 percent of families doubling up in these high-cost cities had incomes of $35,000 or less — suggesting their choices to live in closer quarters may be driven by<strong> </strong>financial need. “We need to build more units,” Divounguy told Vox. “If we had more units then buyers and renters would have more buying power and prices would go down.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DxQ59N">
Christopher Leinberger, a longtime land use strategist, agreed that upzoning — altering rules to allow more dense<strong> </strong>housing in places previously zoned only for single-family homes — is the fundamental prerequisite for creating more family-oriented housing. Without that, he argues, land prices will remain “completely out of whack” and drive up prices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r8X4vT">
“A few decades ago, the plot of land itself would be no more than 20 percent of a home’s price,” Leinberger said. “Today it can be up to 50, 60, or 70 percent.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4ouHkG">
Higher land prices is also a top reason developers <a href="https://www.nytimes.com/2022/09/25/upshot/starter-home-prices.html">don’t bother building entry-level starter homes anymore</a>, even in areas they’re legally allowed to; the increasingly expensive plot of land can’t justify the expense of building a low-cost affordable house.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pvaSxg">
Emily Hamilton, the director of the Urbanity Project at the Mercatus Center, echoes Leinberger and Divounguy in saying that liberalizing zoning laws would help expand family-oriented housing. “Freeing homebuilders to serve a wider variety of households at a broad range of incomes is the path to abundant housing,” she wrote <a href="https://www.discoursemagazine.com/culture-and-society/2023/02/23/zoning-out-american-families/">recently in Discourse magazine</a>. “It would allow more parents to have shorter commutes, freeing more time to spend with their kids.”
</p>
<h3 id="2NO63z">
Other regulatory barriers stand in the way of family-oriented housing
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WQbaFb">
The problem is, as housing advocates are learning, upzoning is not enough.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q3uPaC">
The basic back-of-the-envelope calculations of housing developers in America today are such that if a builder can<em> </em>construct more housing in cities, they will almost always build one- and two-bedroom apartments because smaller units generate more rent per square foot. Developers are, in effect, incentivized to try and pack in<strong> </strong>as many units as they can.
</p>
<aside id="3iLBVC">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sgBdS7">
One option is to pass laws that require developers to include more family-sized units in their portfolio — more three- or four-bedroom places, for example. But housing experts say trying to force developers to build family-oriented housing will probably backfire. “Dictating to developers what their product mix should be is going to be difficult,” said Leinberger. “If you get into the business of legislating that, they’ll just go to some other town.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GKiJhp">
So if you’ve fixed your city’s restrictive zoning, now what?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KKpE0e">
Lewis, of California YIMBY, said they’ve been learning out in the Golden State that the next step is to look at the building codes and other regulatory barriers that influence the types of housing developers choose to build.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8iEz04">
“It’s like whack-a-mole,” he said, meaning just when pro-housing advocates think they’ve defeated the last barrier to new construction, new ones come into clearer view. “These are all arcane rules that no one was paying attention to until five-seven years ago.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nydghE">
One such building code restriction is the requirement that most multifamily buildings have two stairwells. This is a rule rooted in fire safety, though most other countries allow one stairwell and<strong> </strong>opt for other fire safety strategies instead. One consequence of the double stairwell model is it ends up<strong> </strong>making architecture more homogenous and inefficient. (This is why most apartment buildings in America have long central hallways, with apartments on either side.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Amx60o">
Housing activists lately have been rallying around <a href="https://slate.com/business/2021/12/staircases-floor-plan-twitter-housing-apartments.html">“single-staircase” reform</a>, changing building codes to eliminate this requirement for a second stairwell. These reforms will make it easier to use different floorplans and<strong> </strong>hopefully make it more cost-effective to build family-oriented housing in cities — perhaps a three-bedroom, one-and-a-half bath apartment, with only one bedroom having a walk-in closet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="arHHGr">
Lawmakers in Washington state overwhelmingly <a href="https://app.leg.wa.gov/billsummary?BillNumber=5491&amp;Year=2023">approved a bill</a> this month to legalize single-stairwell construction, and California legislators are <a href="https://leginfo.legislature.ca.gov/faces/billNavClient.xhtml?bill_id=202320240AB835">currently pursuing a similar reform</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nG1HIn">
Other barriers include regulations like minimum lot sizes, “set-back” requirements that give towns power to dictate how far back from the curb a home can be built, and “floor-area ratios” — the ratio of a building’s total floor area to the size of the land on which it’s built.
</p>
<aside id="E2EGOv">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GD2LiA">
California Sen. Scott Weiner has been leading the way in his to state to push bills tackling these barriers. “We need to reform zoning, but we also need to end loopholes that make it impossible for our communities to actually build the multifamily housing for which we have already zoned,” <a href="https://sd11.senate.ca.gov/news/20210528-senate-passes-senator-wiener%E2%80%99s-sb-478-housing-opportunity-act">he said</a>.
</p>
<h3 id="BLEEM0">
The risk-averse banks also need to be convinced
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kvgimL">
Unfortunately, adding more homes for families in cities will likely require even more than just making these land-use changes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0u82OD">
Bobby Fijan, a developer who has been trying to build more family-oriented housing in cities, said one of the biggest challenges is convincing American real estate investors that these projects are worthy bets. “I firmly believe it is a chicken and egg problem,” he told Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c9rEF9">
“Real estate in the US is very conservative, they want to back things in a very standardized way, and they want to look and see heaps of data showing something already works,” he said. “In industries like tech and retail, people are obsessed with the question of ‘what does the customer want?’ That’s not a question that’s really asked in real estate.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0o4gBt">
Right now, because the housing supply and demand gap is still so wide, it’s likely that real estate investors will keep backing projects that look like what they’re already building: buildings that cater to childless adults. These are safe bets, with strong track records of delivering returns.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="N5JOCf">
But this doesn’t mean real estate trends can’t change. Fijan has been working to get financing from private equity and is hoping he can build enough “proof points” of successfully profitable family-oriented housing in cities to get the more risk-averse banks to bite in the future.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Cxn7Y4">
It’s a gamble that holds a lot of promise. Plenty of young families will still opt for the suburbs’ greener pastures, but many parents would be happy to stay put in their beloved <a href="https://www.vox.com/the-highlight/2019/9/9/20746436/raising-kids-in-the-city">dense cities and raise their kids</a>. To make that a viable option, though, they need somewhere they can actually live.
</p></li>
<li><strong>As the end of Title 42 nears, Congress is no closer on immigration overhaul</strong> -
<figure>
<img alt="US-MEXICO-IMMIGRATION-POLITICS-MIGRANTS" src="https://cdn.vox-cdn.com/thumbor/i-YUwzgkGbtHKPv0wx5xlnePbtQ=/625x0:5628x3752/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72207154/1247206522.0.jpg"/>
<figcaption>
Rebecca Noble/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Proposed GOP immigration legislation is too harsh, even for some Republicans.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XgCYI7">
House Republicans <a href="https://rollcall.com/2023/04/17/house-republicans-release-sweeping-immigration-bill/">put forth an immigration package Monday</a> which proposes some of the harshest restrictions on migration through the southern border, virtually ending the right to asylum for anyone not crossing through legal ports of entry. Though Sen. Bob Menendez (D-NJ) has put forth a set of recommendations on immigration, as yet there’s no competing legislation to help manage an expected influx of migrants through the southern border this spring and summer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BRoGd6">
The GOP’s extreme border package — which includes an effort to impeach Department of Homeland Security head Alejandro Mayorkas — is unlikely to gain enough votes to pass with the Republicans’s slim majority, but time is running out to pass comprehensive immigration legislation before the Covid-era Title 42 order is set to expire May 11. That order allows the government to deport migrants for public health reasons, without giving them the opportunity to apply for asylum.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2gdnM9">
The end of Title 42 likely portends a fresh wave of migrants coming to the US border to apply for asylum protections — an event for which the system has long been ill-equipped. But instead of providing resources to speed up asylum hearings, for example, perhaps the most alarming aspect of the Republicans’ legislation is that it targets the ability to even seek asylum, <a href="https://www.amnesty.org/en/what-we-do/refugees-asylum-seekers-and-migrants/#:~:text=The%20Universal%20Declaration%20of%20Human,where%20they%20risk%20being%20persecuted">which is affirmed under the Universal Declaration of Human Rights</a>. The US, as a signatory to the declaration, has an obligation to uphold its principles, but the UDHR <a href="https://www.amnesty.org/en/what-we-do/universal-declaration-of-human-rights/">is not a legally binding document</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AR1as4">
<a href="https://www.washingtonpost.com/politics/2023/01/23/house-republicans-immigration-legislation/">Previous legislation</a>, introduced by Rep. Chip Roy (R-TX), set out similarly harsh policies; his bill would allow the DHS head to stop all border crossings of undocumented people through any point of entry so DHS could maintain “operational control” of the border. That legislation, first introduced in January, proved shocking even to some within Roy’s party, including Rep. Tony Gonzalez of Texas.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I30Zpb">
“Trying to ban legitimate asylum claims — one, it’s not Christian, and two, to me, it’s very anti-American,” Gonzalez said. “So a lot is at stake.” Vox reached out to Gonzalez’s office for a comment on Wednesday’s legislation but did not receive a response by press time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FJPs6v">
The latest package is divisive among House Republicans, too, for its attempt to impeach Mayorkas — something <a href="https://www.nytimes.com/2022/11/22/us/kevin-mccarthy-impeach-mayorkas.html">House Speaker Kevin McCarthy threatened to do</a> as part of his turbulent leadership campaign. But in a sharply divided majority, some Republicans see the impeachment efforts as misplaced; “This is really Joe Biden’s policies, more than Mayorkas, and are we going to impeach the president on this? No,” Rep. Don Bacon (R-NE) <a href="https://www.nytimes.com/2023/04/19/us/politics/gop-immigration-house.html">told the New York Times</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ttal66">
Some Republicans also object to changes to a program called E-Verify, which businesses use to cross-check employees’ documentation against DHS and Social Security records. Requiring businesses to use E-Verify could dramatically affect the functioning of the agricultural industry, which relies on undocumented migrant labor.
</p>
<h3 id="BVJtAY">
The end of Title 42 means more people seeking asylum
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q8gQy4">
With the likely end of the Title 42 policy fast approaching, there will be a probable corresponding uptick in asylum seekers, too, as the government won’t be able to use the public health order to remove them. As of December 2022, Title 42 had been used an estimated 2.5 million times to expel migrants since it was put in place in March 2020, the <a href="https://apnews.com/article/biden-mexico-immigration-covid-93d735b9b55c15121c8fc7763fba7e78">Associated Press</a> reported at the time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="p6eLZo">
But, as both Democrats and Republicans have said, the immigration system is unprepared to manage the thousands of people who will attempt a border crossing after Title 42 ends. As Vox reported in December,
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ht7T08">
The fact remains that the immigration system is overstretched and inefficient; the average wait time for immigration cases has skyrocketed from around a year in 1998 to around two and a half years in 2021, <a href="https://trac.syr.edu/phptools/immigration/court_backlog/apprep_backlog_avgdays.php"><strong>according to Syracuse University’s TRAC Immigration system</strong></a>. Migrants are held in substandard, unsafe conditions under the Remain in Mexico program, and both nonprofit and government resources designed to assist them after they reach the US are already overwhelmed.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VcefaU">
US immigration policy has not seen significant changes since the<a href="https://www.congress.gov/bill/101st-congress/senate-bill/358"> Immigration Act of 1990</a>, and the pre-Title 42 asylum system had not been altered since 1980. The Obama administration introduced the Deferred Action for Childhood Arrivals, or DACA program, to protect undocumented people brought to the US as children, but otherwise there has been almost no movement to reform the immigration system <a href="https://www.pewresearch.org/short-reads/2023/01/13/monthly-encounters-with-migrants-at-u-s-mexico-border-remain-near-record-highs/">since 1990. There has been an overall</a> increase in people attempting to enter the US via the southern border — which the right has turned into a culture war bogeyman, best exemplified by former President Donald Trump’s attempt to build a border wall.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="40tnv3">
Under the proposed GOP legislation, migrants would be barred from applying for asylum in the US for a broad swathe of reasons, as Aaron Reichlin-Melnick, policy director at the American Immigration Council, wrote in an <a href="https://immigrationimpact.com/2023/04/19/gop-border-bill-ends-asylum/">April 19 blog post.</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8LuWxw">
Almost all migrants who lived in the US undocumented for more than a year or did not apply for asylum in a third transit country would be barred from the asylum process, as would many people fleeing persecution in their home countries, Reichlin-Melnick wrote. That’s because the bill significantly narrows the definition of who can apply for asylum based on targeting for their political opinion, and would cut off paths to asylum for those fleeing threats from non-state actors, guerrilla or terrorist groups, or gangs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MnMGXi">
“Taken together, these provisions would eliminate the US asylum system as it has existed since the Refugee Act of 1980,” he wrote. “Only those who have the money to buy a direct flight to the United States would have any real chance of access [to] the asylum system—and even then, most would be unable to win given the proposed narrowing of asylum law.”
</p>
<h3 id="1OcRTJ">
What are the alternatives?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dlsxa2">
Menendez, the Democratic head of the Senate Foreign Relations Committee, on Tuesday set out his own plan for managing the influx of migrants, relying primarily on executive orders, rather than congressional action.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ywGKx9">
“Successive U.S. administrations have designed their domestic and foreign policies to respond to shifting needs at the border, an approach that has not created a sustainable long-term solution to a mixed flow of migrants and refugees,” Menendez told <a href="https://www.youtube.com/watch?v=I9_kRz0FxO0">CNN This Morning on Wednesday</a>. “If we continue down the road where we’ve been, which is reactive and responsive and an enforcement-only mechanism, we’re going to continue to have the same problem.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MJ4IbJ">
<a href="https://www.menendez.senate.gov/imo/media/doc/the_menendez_plan.pdf">Menendez’s plan</a> suggests Biden issue executive orders which would increase resources to process asylum seekers at the border — as well as provide for expedited removal for those who don’t qualify. Menendez’s plan also calls for increased access to free legal aid and for people to await asylum hearings in humane conditions, or “non-detention settings.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MZLgTu">
The plan also calls for increased cooperation with Latin American nations to reduce the conditions, like economic necessity and violence, that cause migration, as well as helping Latin American and Caribbean nations manage migration more safely. To that end, <a href="https://www.reuters.com/world/americas/us-panama-colombia-agree-plan-curb-migration-darien-gap-2023-04-12/">the US, Colombia, and Panama</a> have also agreed to work on limiting migration and smuggling through <a href="https://www.cfr.org/article/crossing-darien-gap-migrants-risk-death-journey-us?gclid=Cj0KCQjwi46iBhDyARIsAE3nVrYuJE_cxzGhLErJvrV8w8QYYOb5gxNSZgodqStgT0zrg7QkifjEFlYaAk0JEALw_wcB">the perilous Darien Gap</a>, which has recently become a popular route for people attempting to enter the US.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nnQ1fK">
Menendez’s tactic of going around Congress and advising the White House to issue these orders does, at this point, seem to be the only likely way to make any changes on immigration for the time being. But unless and until there’s any effort from Congress to address the US’s immigration system as well as the causal factors that drive it, these programs are always in danger of elimination by the next administration. With just a year and a half till the 2024 elections, the programs Menendez suggests could be eliminated before they can prove effectiveness.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SzcQIC">
In the meantime, the GOP is continuing to move forward with its extremist immigration policies — without a guaranteed winning strategy, but also without a clear legislative alternative that can manage the arrival of thousands of asylum-seekers and migrants over the next several months.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>50th Birthday: the A to Z of Sachin Tendulkar</strong> - As India’s favourite son Sachin Tendulkar completes his 50th birthday on April 24, his life and times chronicled in an alphabetical manner. It could be people, places and events related to the great man</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wrestler Bajrang Punia on protest against WFI: ‘Nothing has been done so far to resolve our issues’</strong> - Top Indian wrestlers, including Bajrang Punia, Vinesh Phogat, Ravi Dahiya, and Sakshi Malik, on Sunday gave details about the legal process in their dispute against the Wrestling Federation of India</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wrexham seal promotion to English Football League with blockbuster win</strong> - All eyes were on the Welsh club owned by Hollywood actors Ryan Reynolds and Rob McElhenney.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gervonta Davis knocks out Ryan Garcia with body shot in Las Vegas</strong> - Gervonta Davis delivered a stunning body shot in the seventh round, causing Ryan Garcia to stumble back and then go to a knee, ending a highly anticipated bout with a knockout at 1:44</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India makes a strong case for including wrestling, archery and kabaddi at CWG’s regional meet</strong> - While kabaddi was never a part of the Commonwealth Games programme, Indian athletes have excelled in shooting and archery before they were done away during previous Games in Birmingham</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>13 red sanders smugglers held, logs worth ₹71 lakh seized in Tirupati</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Alliance for an Energy Efficient Economy to help A.P. govt. implement energy-efficiency projects</strong> - Energy Conservation Cell is a thoughtful step towards encouraging efficient use of energy and ensuring reduction of consumption, says AEEE president Satish Kumar</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chhattisgarh Police arrest 3 Naxalites in Narayanpur district</strong> - The three people were active under the Nelnar area committee of Maoists and allegedly involved in incidents of murder, planting IEDs, and blocking roads by felling trees, an official said</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amul-Nandini was made emotional issue due to Karnataka polls: Nirmala Sitharaman</strong> - Nirmala Sitharaman was responding to a question regarding the Amul-Nandini controversy, during the interaction with Thinkers Forum, Karnataka</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>JD(S) candidate B.A. Mohiuddin Bava and his wife have income tax dues of ₹1.17 crore</strong> - Mr. Bava, who contested on a Congress ticket in 2008, 2013 and 2018 polls, moved to the JD(S) following denial of ticket from the Congress</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Michael Schumacher: Magazine editor sacked over AI-generated ‘interview’ with seven-time F1 champion</strong> - The editor of a German magazine that published an artificial intelligence-generated ‘interview’ with Michael Schumacher has been sacked.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vladimir Kara-Murza: Family’s heartbreak at Putin critic’s jail term</strong> - Vladimir Kara-Murza’s wife Evgenia does not know if she or their children will see him again.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia’s Belgorod sees mass evacuations over undetonated bomb</strong> - An undetonated bomb was found in Belgorod, where a jet accidentally dropped another bomb days earlier.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Flambé fire kills two in Madrid restaurant</strong> - Another ten people are injured after plastic plants caught fire as a waiter flambéed a dish.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Paris synagogue bomber convicted after 43 years</strong> - Hassan Diab refused to leave Canada to attend the trial into the murder of four people.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A warmer planet, less nutritious plants and … fewer grasshoppers?</strong> - Higher levels of carbon dioxide are changing micronutrients in grasses, trees, and kelp. - <a href="https://arstechnica.com/?p=1933765">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In the end, Picard became the fan-service TNG reunion it always should have been</strong> - Final season finally gives the <em>TNG</em> crew a better send-off than 2002’s <em>Nemesis</em>. - <a href="https://arstechnica.com/?p=1932606">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>When a plan comes together: Inside a massive Eve Online corporate heist</strong> - “It all needed to appear as business as usual.” - <a href="https://arstechnica.com/?p=1933280">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Access to abortion pill is spared; SCOTUS freezes lower court’s order</strong> - The court did not explain its reasoning. - <a href="https://arstechnica.com/?p=1933736">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple will launch a journaling app in iOS 17, but that’s bad news for some devs</strong> - It could monitor users’ activities through the day in ways other apps can’t. - <a href="https://arstechnica.com/?p=1933618">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>My paraplegic girlfriend just broke up with me.</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She said all I do is push her around and talk about her behind her back.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/shittycommentdude"> /u/shittycommentdude </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/12viy9q/my_paraplegic_girlfriend_just_broke_up_with_me/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/12viy9q/my_paraplegic_girlfriend_just_broke_up_with_me/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What’s your name son?</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The principal asked his student. The kid replied, “D-d-d-dav-dav-david, sir.” “Do you have a stutter?” the principal asked. The student answered, “No sir, my dad has a stutter but the guy who registered my name was a real jerk.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/BallsHangLowAF"> /u/BallsHangLowAF </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/12vycvz/whats_your_name_son/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/12vycvz/whats_your_name_son/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why is LGBTQ+ month in June and not September?</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Because pride comes before the fall.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
(Bad joke, I know)
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Conrad417"> /u/Conrad417 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/12vqn8k/why_is_lgbtq_month_in_june_and_not_september/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/12vqn8k/why_is_lgbtq_month_in_june_and_not_september/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>During the War, some German PoWs were working in a field in England when one of them called out to the guard.</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
By the bank of a nearby river a small boy was screaming for help. His dog had jumped in the river and couldn’t get out. The German yelled “I go help, <em>ja</em>?”. The guard gave him the okay and the German ran and jumped in the river.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In a few moments he had freed the dog from the weed it was tangled in, and he was helping the dog up onto the bank. He scrambled up and said to the tearful boy, “Take home the dog straight avay and mit a rough towel give him good rub down. Put his basket near the fire. Give him little bit varm vater and milk to drink, also tiny spoonful of brandy if you haff. He be fine by tomorrow.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Wow!” says the round-eyed boy. “Are you a vet?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Vet?” snorts the German. “I am <em>fucking soaked</em>!”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Gil-Gandel"> /u/Gil-Gandel </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/12w22oj/during_the_war_some_german_pows_were_working_in_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/12w22oj/during_the_war_some_german_pows_were_working_in_a/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>If Marie Antoinette, Anne Boleyn, Charles I, and Louis XVI formed a band, what would its name be?</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Talking Heads.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/CamilaCazzy"> /u/CamilaCazzy </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/12w0abf/if_marie_antoinette_anne_boleyn_charles_i_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/12w0abf/if_marie_antoinette_anne_boleyn_charles_i_and/">[comments]</a></span></p></li>
</ul>
<script>AOS.init();</script></body></html>

4
index.html
View File

File diff suppressed because one or more lines are too long