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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<li><a href="#from-preprints">From Preprints</a></li>
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<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
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<li><a href="#from-pubmed">From PubMed</a></li>
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<li><a href="#from-patent-search">From Patent Search</a></li>
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<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
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<li><strong>Inequality in employment trajectories and their socio-economic consequences during the early phase of the COVID-19 pandemic in Germany</strong> -
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This paper evaluates the inequalities in employment trajectories during the first COVID-19 pandemic lockdown in Germany. We assess individual-level panel data collected weekly between 20 March and 25 June (N=2,297), which allows us to examine the risks of short-time work, furlough, and job loss, as well as changes between working on-site and from home. Using sequence analysis, we detect typical patterns of employment trajectories and analyse how these vary between socio-demographic groups. Finally, we relate the types of employment trajectories to changes in income, subjective job security (compared to values in January and February 2020), and COVID-19 infection risks. Our results show clear gradients in employment risks: low-wage workers were severely affected by furlough and job loss, while highly qualified employees were able to work from home. Furthermore, in contrast to previous crises, service sector and female employees were more affected by short-time work; however, its timing and duration differs compared to male workers in manufacturing. Income loss was pronounced among those who became unemployed and those continuously in short-term work, while everybody—including employees continuously working from home—experienced a significant reduction in subjective job security compared to employees whose employment hours or location have not changed. The infection risk was only increased for individuals who changed from furlough to working on-site.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/m95df/" target="_blank">Inequality in employment trajectories and their socio-economic consequences during the early phase of the COVID-19 pandemic in Germany</a>
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<li><strong>ACE2 polymorphisms interplay with the apelinergic peptide system: potential tools for COVID-19 diagnosis and treatment</strong> -
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Aiming to decrease the unexplained COVID-19 mortality in some young and otherwise healthy patients, including health care professionals, we suggest that ACE2 polymorphisms might be reflected through under/overexpression of ACE2 transcribed or regulated proteins including the activity of metaloproteinsase-2 and apelin-13 and 36 cleavage, leading to unexpected immune responses and complications. We might detect the higher vulnerable groups if a genetic test to detect potential associated variant ACE2 alleles, or a serological test to detect the suggested associated proteins, could be developed and linked to those cases of unexpected complications and/or mortality. Furthermore, basing on the same hypothesis, we suggest testing infusion of apelin-13 to treat critical cases of COVID-19, especially those complaining of advanced heart failure.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/enjxt/" target="_blank">ACE2 polymorphisms interplay with the apelinergic peptide system: potential tools for COVID-19 diagnosis and treatment</a>
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<li><strong>SARS CoV-2 Replication Attributed to Guanylate kinase 1: A Concise SWOT Analysis</strong> -
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A recent interesting study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we argue that though this hypothesis might prove valid, GK 1 inhibitors are very unlikely, at least for the short term, to be beneficial in clinical management of COVID-19. However, we recommend conducting focused genetic studies to test their suggested hypothesis as it might add to our knowledge of some COVID-19 encountered idiosyncratic morbidity and mortality outcomes.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/yvc56/" target="_blank">SARS CoV-2 Replication Attributed to Guanylate kinase 1: A Concise SWOT Analysis</a>
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<li><strong>Tocilizumab, Remdesivir, Favipiravir and Dexamethasone Repurposed for COVID-19: The Risk Benefit Ratio at a Glance.</strong> -
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In this manuscript, we discuss the expectations versus the real word results of four repurposed COVID-19 drugs; tocilizumab, remdesivir, favipiravir and dexamethasone from a pharmacovigilant point of view. We recommend considering a personalized risk benefit ratio before a decision is made using any of these drugs. We suggest that though the results of phase III clinical trials have been less than expected; tocilizumab might have a potential to treat some critical cases of COVID-19. On the contrary, remdesivir, though its FDA approval, together with favipiravir are least likely to benefit COVID-19 patients. Finally, we recommend that the RECOVERY dexamethasone should only be further investigated and to be considered only for critical cases of hospitalized COVID-19 patients and we urge physicians in the developing countries to avoid and stop using it in mild-moderate COVID-19 cases.
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🖺 Full Text HTML: <a href="https://osf.io/vhqgy/" target="_blank">Tocilizumab, Remdesivir, Favipiravir and Dexamethasone Repurposed for COVID-19: The Risk Benefit Ratio at a Glance.</a>
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<li><strong>Information about herd immunity through vaccination and empathy promote COVID-19 vaccination intentions</strong> -
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Objective: An effective vaccine against COVID-19 is a desired solution to curb the spread of the disease. However, vaccine hesitancy might hinder high uptake rates and thus undermine efforts to eliminate COVID-19 once an effective vaccine became available. The present contribution addresses this issue by examining two ways of increasing the intention to get vaccinated against COVID-19. Methods: Two pre-registered online studies were conducted (N = 2,315 participants from the UK) in which knowledge about and beliefs in herd immunity through vaccination, as well as empathy for those most vulnerable to the virus, were either measured (Study 1) or manipulated (Study 2). As a dependent variable, individuals’ self-reported vaccination intention once a vaccine against COVID-19 became available was assessed. Results: In Study 1 (N = 310), the intention to get vaccinated against COVID-19 was correlated with knowledge about and belief in herd immunity (r = .58, p < .001), as well as with empathy for those most vulnerable to the virus (r = .26, p < .001). In Study 2 (N = 2,005), information about herd immunity (Cohen’s d = 0.13, p = .003) and empathy (Cohen’s d = 0.22, p < .001) independently promoted vaccination intention. Conclusions: The motivation to get vaccinated against COVID-19 was related to and could be causally promoted by both mere information about herd immunity and by empathy. As such, the present research provides a better understanding of the intention to get vaccinated against COVID-19.
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🖺 Full Text HTML: <a href="https://psyarxiv.com/wzu6k/" target="_blank">Information about herd immunity through vaccination and empathy promote COVID-19 vaccination intentions</a>
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<li><strong>Role of Immunity and Inflammation Mediators in Early COVID-19 Management: Genetic Results Interpretations Versus Real-life Practice.</strong> -
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Pairo-Castineira et al. have recently demonstrated that altered expression of certain genes related to the immune and inflammatory systems reduced the odds of severe COVID-19 and protected against it; we agree with their results from a clinical perspective. However, they have suggested some drugs, including barictinib, to be of priority to be tested basing on their results. We present a concise analysis of these results according to our real-life and academic experience that disagree with some of their recommendations from a clinical and pharmacovigilant point of view. Further, we confirm that the important results released Pairo-Castineira et al. confirm the validity to our recommended real-life used protocol using non-steroidal anti-inflammatory drugs, nitazoxanide and azithromycin to manage COVID-19 patients.
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🖺 Full Text HTML: <a href="https://osf.io/cuyrx/" target="_blank">Role of Immunity and Inflammation Mediators in Early COVID-19 Management: Genetic Results Interpretations Versus Real-life Practice.</a>
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<li><strong>Psychological Science in the Wake of COVID-19: Social, Methodological, and Meta-Scientific Considerations</strong> -
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The COVID-19 pandemic has extensively changed the state of psychological science, from what research questions psychologists can ask to which methodologies psychologists can employ to investigate them. In this article, we offer a perspective on how to optimize new research in the pandemic’s wake. As this pandemic is inherently a social phenomenon—an event that hinges upon human-to-human contact—we focus on socially relevant subfields of psychology. We highlight specific psychological phenomena that have likely shifted due to the pandemic and discuss theoretical, methodological, and practical considerations of conducting research on these phenomena. Following this discussion, we evaluate meta-scientific issues that have been amplified by the pandemic. We aim to demonstrate how theoretically grounded views on the COVID-19 pandemic can help make psychological science stronger—not weaker—in its wake.
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🖺 Full Text HTML: <a href="https://psyarxiv.com/6gjfm/" target="_blank">Psychological Science in the Wake of COVID-19: Social, Methodological, and Meta-Scientific Considerations</a>
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<li><strong>Rural Safety Net Use During the Covid-19 Pandemic</strong> -
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Despite unparalleled government relief spending, many households have fallen into financial distress during the Covid-19 pandemic. At the same time, reports of non-governmental forms of disaster aid - both from organizations and among individuals - are widespread. Given that formal government programs have not fully met the material needs of many households across the United States during the pandemic, we build on disaster scholarship to compare utilization of three distinct forms of disaster support to better understand how households are getting by: (1) government safety net programs, (2) not-for-profit support, and (3) informal social support. We focus our study on a large, yet especially vulnerable and under-researched population: rural residents across the Western U.S. Drawing on results from a representative survey fielded during the summer of 2020, we find that informal social support was the most widely used safety net, with over half of all residents giving or receiving some form of informal support. However, differences in age, education, sex, race, ethnicity, and homeownership status variously predicted different types of safety net use, demonstrating the unevenness of pandemic impacts and access to relief resources across demographic groups. Finally, rural residents who experienced the worst pandemic impacts were the most likely to utilize any of the three forms of safety nets examined. Despite identified limitations to government relief, both formal government programs and informal social support systems were utilized by those most affected by the pandemic.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/vrb8q/" target="_blank">Rural Safety Net Use During the Covid-19 Pandemic</a>
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<li><strong>A time travel amidst a recession</strong> -
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Since I was born in 1998, three major international economic crises had hit: the Asian financial crisis in 1997-1999, the Dotcom bubble in the early 2000s, and the 2007- 2008 financial crisis. And now, the world is undergoing another economic downturn due to the spread of the COVID-19 pandemic.
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🖺 Full Text HTML: <a href="https://osf.io/yseqw/" target="_blank">A time travel amidst a recession</a>
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<li><strong>Diclofenac potassium/Nitazoxanide/Azithromycin Used in Adults, Children and Pregnant Patients: A Novel Potential Game Changer COVID-19 Protocol.</strong> -
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Background: The current pandemic of coronavirus disease 2019 has necessitated trial of several drugs searching for a potential cure. We developed a novel protocol basing on our early pioneering article that recommended and justified adoption of nitazoxanide/azithromycin for early cases of COVID-19 which was followed by two published articles to justify addition of non-steroidal anti-inflammatory drugs to nitazoxanide/azithromycin. Notably, nitazoxanide/azithromycin is currently being proven clinically beneficial by other researchers and several clinical trials are currently registered to test the potential benefit of NSAIDs in COVID-19 patients and some countries have already included them in their official COVID-19 management protocols. Patients and methods: The author is presenting his telemedicine experience through a prospective case series involving consented twenty-seven confirmed and highly suspected COVID-19 Egyptian patients including 13 adult males, 8 adult females, 2 pregnant patients as well as 4 children. All patients have received a 5-day-regimen of NSAIDs (diclofenac potassium, ibuprofen or ketoprofen)/nitazoxanide/azithromycin +/- cefoperazone either in full or in part as illustrated in the manuscript. The primary endpoint of this protocol was full relief of all serious COVID-19 symptoms and signs like fever, progressive cough, moderate/severe dyspnea or disturbed level of consciousness. Results: The primary endpoint was fully achieved in all patients within two weeks. Most of the patients treated early with the protocol have fully recovered during its described five days; the leucocytic/lymphocytic count was significantly improved for those with prior leucopenia/lymphopenia. No significant adverse effects were reported. Conclusion: A novel short course COVID-19 protocol using inexpensive FDA approved drugs is illustrated and it might be considered when adopted.
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🖺 Full Text HTML: <a href="https://osf.io/vmq3y/" target="_blank">Diclofenac potassium/Nitazoxanide/Azithromycin Used in Adults, Children and Pregnant Patients: A Novel Potential Game Changer COVID-19 Protocol.</a>
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<li><strong>Health Protocol Sanctions in Sorong Mayor Regulation Number 17 of 2020</strong> -
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This study aims to analyze the legal sanctions for public health protocols in Article 7 of Sorong Mayor's Regulation Number 17 of 2020. The type of research used in this study is a type of juridical normative research which is analyzed qualitatively with a statutory approach. The results of this study indicate that the sanctions in the form of monetary fines as stipulated in Article 7 paragraph (2) letter a do not have a firm legal basis, and tend to have the potential to disrupt economic activities to improve people's welfare, especially in the era of the COVID-19 pandemic.
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🖺 Full Text HTML: <a href="https://osf.io/3hxgr/" target="_blank">Health Protocol Sanctions in Sorong Mayor Regulation Number 17 of 2020</a>
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<li><strong>A comparative survey of Betacoronavirus binding dynamics relevant to the functional evolution of the highly transmissible SARS-CoV-2 variant N501Y</strong> -
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Comparative functional analysis of the binding interactions between various Betacoronavirus mutant strains and their potential multiple human target proteins is crucial for a more complete understanding of zoonotic spillovers of viruses that cause diseases like COVID-19. Here, employing hundreds of replicate sets of nanosecond scale GPU accelerated molecular dynamics simulations, we statistically compare atom motions of ACE2 and CD26 target proteins in both the presence and absence of different strains of the viral receptor binding domain (RBD) of the S spike glycoprotein. In all strains, we demonstrate a universally conserved functional binding signature of the viral RBD with the N-terminal helices of ACE2. We also identify a second more dynamically transient interaction of the viral N501 with the previously confirmed ACE2 K353 and two nearby novel sites, Q325 and the AAQPFLL 386-92 motif. We propose a model of the functional evolution of SARS-type zoonotic spillovers involving both (A) a conserved binding interaction with the N-terminal helices of ACE2 that is preadapted from viral interaction of the Tylonycteris bat coronavirus progenitor strain HKU4 with the SAMLI 291-5 motif in protein CD26 and (B) a more promiscuous and likely more evolvable interaction between viral N501 and the above-mentioned multiple regions of ACE2 that is preadapted from the bat viral interaction at the CD26 SS 333-4 motif. Our recent analysis of the highly transmissible N501Y lineage B.1.1.7 mutation in SARS-CoV-2 also supports this model, identifying a less promiscuous Y501 interaction with ACE2 that favors more stable functional binding with the K353 site alone.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.09.11.293258v2" target="_blank">A comparative survey of Betacoronavirus binding dynamics relevant to the functional evolution of the highly transmissible SARS-CoV-2 variant N501Y</a>
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<li><strong>pyrpipe: a python package for RNA-Seq workflows</strong> -
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The availability of terabytes of RNA-Seq data and continuous emergence of new analysis tools, enable unprecedented biological insight. However, implementing RNA-Seq analysis pipelines in a reproducible, flexible manner is challenging as data gets bigger and more complex. Thus, there is a pressing requirement for frameworks that allows for fast, efficient, easy-to-manage, and reproducible analysis. Simple scripting has many challenges and drawbacks. We have developed a python package, python RNA-Seq Pipeliner (pyrpipe) that enables straightforward development of flexible, reproducible and easy-to-debug computational pipelines purely in python, in an object-oriented manner. pyrpipe provides access to popular RNA-Seq tools, within python, via easy-to-use high level APIs. Pipelines can be customized by integrating new python code, third-party programs, or python libraries. Users can create checkpoints in the pipeline or integrate (pyrpipe) into a workflow management system, thus allowing execution on multiple computing environments. pyrpipe produces detailed analysis, and benchmark reports which can be shared or included in publications. pyrpipe is implemented in python and is compatible with python versions 3.6 and higher. To illustrate the rich functionality of pyrpipe, we provide case studies using RNA-Seq data from GTEx, SARS-CoV-2-infected human cells, and Zea mays. All source code is freely available at https://github.com/urmi-21/pyrpipe; the package can be installed from the source or from PyPI (https://pypi.org/project/pyrpipe). Documentation is available at (http://pyrpipe.rtfd.io).
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.03.04.925818v4" target="_blank">pyrpipe: a python package for RNA-Seq workflows</a>
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<li><strong>Large scale genomic and evolutionary study reveals SARS-CoV-2 virus isolates from Bangladesh strongly correlate with European origin and not with China.</strong> -
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Rationale: The global public health is in serious crisis due to emergence of SARS-CoV-2 virus. Studies are ongoing to reveal the genomic variants of the virus circulating in various parts of the world. However, data generated from low- and middle-income countries are scarce due to resource limitation. This study was focused to perform whole genome sequencing of 151 SARS-CoV-2 isolates from COVID-19 positive Bangladeshi patients. The goal of this study was to identify the genomic variants among the SARS-CoV-2 virus isolates in Bangladesh, to determine the molecular epidemiology and to develop a relationship between host clinical trait with the virus genomic variants. Method: Suspected patients were tested for COVID-19 using one step commercial qPCR kit for SARS-CoV-2 Virus. Viral RNA was extracted from positive patients, converted to cDNA which was amplified using Ion AmpliSeq SARS-CoV-2 Research Panel. Massive parallel sequencing was carried out using Ion AmpliSeq Library Kit Plus. Assembly of raw data is done by aligning the reads to a pre-defined reference genome (NC_045512.2) while retaining the unique variations of the input raw data by creating a consensus genome. A random forest-based association analysis was carried out to correlate the viral genomic variants with the clinical traits present in the host. Result: Among the 151 viral isolates, we observed the 413 unique variants. Among these 8 variants occurred in more than 80 % of cases which include 241C to T, 1163A to T, 3037C to T,14408C to T, 23403A to G, 28881G to A, 28882 G to A, and finally the 28883G to C. Phylogenetic analysis revealed a predominance of variants belonging to GR clade, which have a strong geographical presence in Europe, indicating possible introduction of the SARS-CoV-2 virus into Bangladesh through a European channel. However, other possibilities like a route of entry from China cannot be ruled out as viral isolate belonging to L clade with a close relationship to Wuhan reference genome was also detected. We observed a total of 37 genomic variants to be strongly associated with clinical symptoms such as fever, sore throat, overall symptomatic status, etc. (Fishers Exact Test p-value<0.05). The most mention-worthy among those were the 3916CtoT (associated with causing sore throat, p-value 0.0005), the 14408C to T (associated with protection from developing cough, p-value= 0.027), and the 28881G to A, 28882G to A, and 28883G to C variant (associated with causing chest pain, p-value 0.025). Conclusion: To our knowledge, this study is the first large scale phylogenomic studies of SARS-CoV-2 virus circulating in Bangladesh. The observed epidemiological and genomic features may inform future research platform for disease management, vaccine development and epidemiological study.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.17.425424v1" target="_blank">Large scale genomic and evolutionary study reveals SARS-CoV-2 virus isolates from Bangladesh strongly correlate with European origin and not with China.</a>
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<li><strong>The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS</strong> -
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Acute lung immunity to inhaled pathogens elicits defensive pneumonitis that may convert to the Acute Respiratory Distress Syndrome (ARDS), causing high mortality. Mechanisms underlying the conversion are not understood, but are of intense interest because of the ARDS-induced mortality in the ongoing Covid-19 pandemic. Here, by optical imaging of live lungs we show that key to the lethality is the functional status of mitochondrial Ca2+ buffering across the mitochondrial Ca2+ uniporter (MCU) in the alveolar type 2 cells (AT2), which protect alveolar stability. In mice subjected to ARDS by airway exposure to lipopolysaccharide (LPS), or to Pseudomonas aeruginosa, there was marked loss of MCU expression in AT2. The ability of mice to survive ARDS depended on the extent to which the MCU expression recovered, indicating that the viability of Ca2+ buffering by AT2 mitochondria critically determines ARDS severity. Mitochondrial transfer to enhance AT2 MCU expression might protect against ARDS.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.18.427173v1" target="_blank">The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dexamethasone for COVID-19</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Drug: Dexamethasone<br/><b>Sponsor</b>: University of Oklahoma<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial)</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Ivermectin 0.6mg/kg/day; Drug: Ivermectin 1.0mg/kg/day; Drug: Placebo; Drug: Hydroxychloroquine<br/><b>Sponsor</b>: Corpometria Institute<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: ORTD-1 low dose; Drug: ORTD-1 mid dose; Drug: ORTD-1 high dose; Other: Vehicle control<br/><b>Sponsor</b>: Oryn Therapeutics, LLC<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Diagnostic Test: Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process<br/><b>Sponsor</b>: Hospices Civils de Lyon<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMUNOR® Preparation in the Prevention of COVID-19</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Drug: IMUNOR<br/><b>Sponsor</b>: University Hospital Ostrava<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Adult</strong> - <b>Condition</b>: Covid19 Vaccine<br/><b>Interventions</b>: Biological: MVC-COV1901(S protein with adjuvant); Biological: MVC-COV1901(Saline)<br/><b>Sponsor</b>: Medigen Vaccine Biologics Corp.<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Vitamin C 500 MG Oral Tablet; Drug: Tenofovir disoproxyl fumarate 300 MG Oral Tablet; Drug: Tenofovir disoproxyl fumarate 300 MG plus emtricitabine 200 MG Oral Tablet<br/><b>Sponsors</b>: Universidade Federal do Ceara; Conselho Nacional de Desenvolvimento Científico e Tecnológico; São José Hospital for Infectious Diseases - HSJ; Central Laboratory of Public Health of Ceará - Lacen-CE<br/><b>Recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Safety and Efficacy of Pyronaridine-artesunate (Pyramax® or Artecom®)in COVID-19 Patients</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Artecom® (pyronaridine-artesunate); Drug: Placebo<br/><b>Sponsor</b>: Shin Poong Pharmaceutical Co. Ltd.<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Participants ≥ 60 Years of Age and Hospitalized With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: BGE-175; Other: Placebo<br/><b>Sponsor</b>: BioAge Labs, Inc.<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Drug: Betadine© bucal 100 mg/ml; Drug: Oximen® 3%; Drug: Clorhexidine Dental PHB©; Drug: Vitis Xtra Forte©; Drug: Distilled Water<br/><b>Sponsors</b>: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; Hospital Universitario Fundación Jiménez Díaz; Hospital Universitario General de Villalba; Hospital Universitario Infanta Elena; Hospital Universitario Virgen de la Arrixaca; Hospital Clínico Universitario de Valencia; Dentaid SL<br/><b>Completed</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Deep Breathing Exercise on Dyspnea, Anxiety and Quality of Life in Patients Treated for COVID-19</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Behavioral: Deep Breathing Exercise with Triflo<br/><b>Sponsor</b>: Ankara University<br/><b>Not yet recruiting</b></p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RU Anti-SARS-CoV-2 (COVID-19) mAbs in Healthy Volunteers</strong> - <b>Condition</b>: Covid19<br/><b>Intervention</b>: Biological: C144-LS and C-135-LS<br/><b>Sponsor</b>: Rockefeller University<br/><b>Recruiting</b></p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia</strong> - <b>Condition</b>: COVID-19 Pneumonia<br/><b>Intervention</b>: Drug: Cefditoren pivoxil 400mg<br/><b>Sponsor</b>: Meiji Pharma Spain S.A.<br/><b>Recruiting</b></p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of COVID-19 Outbreak in Hospital Departments of Bamako, Mali</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Diagnostic Test: SARS-CoV-2 screening by molecular biology; Diagnostic Test: Serological screening<br/><b>Sponsor</b>: Institut National de la Santé Et de la Recherche Médicale, France<br/><b>Not yet recruiting</b></p></li>
|
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|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19</strong> - <b>Condition</b>: Covid19<br/><b>Interventions</b>: Dietary Supplement: Glycine; Dietary Supplement: N-acetylcysteine; Dietary Supplement: Alanine<br/><b>Sponsor</b>: Baylor College of Medicine<br/><b>Recruiting</b></p></li>
|
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|
</ul>
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<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
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<ul>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Purinergic Signaling of ATP in COVID-19 Associated Guillain-Barre Syndrome</strong> - Declared as a global public health emergency, coronavirus disease 2019 (COVID-19) is presented as a disease of the respiratory tract, although severe cases can affect the entire organism. Several studies have shown neurological symptoms, ranging from dizziness and loss of consciousness to cerebrovascular and neurodegenerative diseases. In this context, Guillain-Barré syndrome, an immune-mediated inflammatory neuropathy, has been closely associated with critical cases of infection with "severe...</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mass spectrometry reveals potential of beta-lactams as SARS-CoV-2 M(pro) inhibitors</strong> - The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some β-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the efficacy and safety of inhaled magnesium sulphate in combination with standard treatment in patients with moderate or severe COVID-19: A structured summary of a study protocol for a randomised controlled trial</strong> - OBJECTIVES: Basic and clinical studies have shown that magnesium sulphate ameliorates lung injury and controls asthma attacks by anti-inflammatory and bronchodilatory effects. Both intravenous and inhaled magnesium sulphate have a clinical impact on acute severe asthma by inhibition of airway smooth muscle contraction. Besides, magnesium sulphate can dilate constricted pulmonary arteries and reduce pulmonary artery resistance. However, it may affect systemic arteries when administered...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design</strong> - The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to more than 70 million infections and over 1.6 million of deaths worldwide in the past few months. None of the efficacious antiviral agents against human CoVs have been approved yet. 3C-like protease (3CL^(pro) ) is an attractive target...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19</strong> - We describe the cytokine profiles of a large cohort of hospitalized patients with moderate to critical COVID-19, focusing on IL-6, sIL2R, and IL-10 levels before and after receiving immune modulating therapies, namely, tocilizumab and glucocorticoids. We also discuss the possible roles of sIL2R and IL-10 as markers of ongoing immune dysregulation after IL-6 inhibition. We performed a retrospective chart review of adult patients admitted to a tertiary care center with moderate to critical...</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Natural agents modulating ACE-2: A review of compounds with potential against SARS-CoV-2 infections</strong> - One of the biggest challenges of public health worldwide is reducing the number of events and deaths related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The angiotensin-converting enzyme 2 (ACE2), a carboxypeptidase that degrades angiotensin II into angiotensin 1-7, has been identified as a potent receptor for SARSCoV-2. In the last decades, ACE inhibition has assumed a central role in reducing cardiovascular and renal events. However, with the advent of COVID-19,...</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An in silico analysis of Ibuprofen enantiomers in high concentrations of sodium chloride with SARS-CoV-2 main protease</strong> - 2020 will be remembered worldwide for the outbreak of Coronavirus disease (COVID-19), which quickly spread until it was declared as a global pandemic. The main protease (Mpro) of SARS-CoV-2, a key enzyme in coronavirus, represents an attractive pharmacological target for inhibition of SARS-CoV-2 replication. Here, we evaluated whether the anti-inflammatory drug Ibuprofen, may act as a potential SARS-CoV-2 Mpro inhibitor, using an in silico study. From molecular dynamics (MD) simulations, we also...</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular docking and simulation studies of natural compounds of Vitex negundo L. against papain-like protease (PL(pro)) of SARS CoV-2 (coronavirus) to conquer the pandemic situation in the world</strong> - The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is β-coronavirus that is responsible for the pandemic coronavirus disease 2019 (COVID-19) all over the world. The rapid spread of the novel SARS CoV-2 worldwide is raising a significant global public health issue with nearly 61.86 million people infected and 1.4 million deaths. To date, no specific drugs are available for the treatment of COVID-19. The inhibition of proteases essential for the proteolytic treatment of viral...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Withanolides from Withania somnifera as an immunity booster and their therapeutic options against COVID-19</strong> - Traditionally, Withania somnifera is widely used as an immune booster, anti-viral, and for multiple medicinal purposes. The present study investigated the withanolides as an immune booster and anti-viral agents against the coronavirus-19. Withanolides from Withania somnifera were retrieved from the open-source database, their targets were predicted using DIGEP-Pred, and the protein-protein interaction was evaluated. The drug-likeness score and intestinal absorptivity of each compound were also...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential health benefits of zinc supplementation for the management of COVID-19 pandemic</strong> - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent for the Coronavirus Disease 2019 (COVID-19). The COVID-19 pandemic has created unimaginable and unprecedented global health crisis. Since the outbreak of COVID-19, millions of dollars have been spent, hospitalization overstretched with increasing morbidity and mortality. All these have resulted in unprecedented global economic catastrophe. Several drugs and vaccines are currently being evaluated, tested,...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compounds of Citrus medica and Zingiber officinale for COVID-19 inhibition: in silico evidence for cues from Ayurveda</strong> - CONCLUSION: In silico studies suggest that the phytochemical compounds in C. medica and Z. officinale may have good potential in reducing viral load and shedding of SARS-CoV-2 in the nasal passages. Further studies are recommended to test its efficacy in humans for mitigating the transmission of COVID-19.</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Factual insights of the allosteric inhibition mechanism of SARS-CoV-2 main protease by quercetin: an in silico analysis</strong> - SARS-CoV-2 main protease (M^(pro)) cleaves the viral polypeptide 1a and 1ab in a site-specific ((L-Q|(S, A, G)) manner and produce functional enzymes for mediating viral replication. Numerous studies have reported synthetic competitive inhibitors against this target enzyme but increase in substrate concentration often reduces the effectiveness of such inhibitors. Allosteric inhibition by natural compound can provide safe and effective treatment by alleviating this limitation. Present study deals...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2</strong> - The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in outbreak of global pandemic, fatal pneumonia in human referred as Coronavirus Disease-2019 (Covid-19). Ayurveda, the age old practice of treating human ailments in India, can be considered against SARS-CoV-2. Attempt was made to provide preliminary evidences for interaction of 35 phytochemicals from two plants (Phyllanthus amarus and Andrographis paniculata used in Ayurveda) with SARS-CoV-2 proteins (open & closed...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional chinese medicines</strong> - Coronavirus disease-2019 (COVID-19) has become a major global epidemic. Facilitated by HTS² technology, we evaluated the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on cytokine storm-related signaling pathways, and identified the key targets of the relevant pathways and potential active ingredients in these herbs. This large-scale transcriptional study innovatively combines HTS² technology with bioinformatics methods and computer-aided drug design. For the first time, it...</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protease inhibitor GC376 for COVID-19: Lessons learned from feline infectious peritonitis</strong> - The main protease (M^(pro)) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important therapeutic target as it plays a major role in the processing and maturation of the viral polyprotein. GC376 is a pre-clinical dipeptide-based protease inhibitor that has been previously used for managing feline infectious peritonitis virus (FIPV). Since both GC373 and GC376 have already been successfully used in treating animal coronavirus infection, they can be considered as strong drug...</p></li>
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<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU314054415">link</a></p></li>
|
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313300659">link</a></p></li>
|
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid 19 - Chewing Gum</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313269181">link</a></p></li>
|
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19</strong> - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN313339294">link</a></p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fahrzeuglüftungssystem und Verfahren zum Betreiben eines solchen Fahrzeuglüftungssystems</strong> -
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</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Die Erfindung betrifft ein Fahrzeuglüftungssystem (1) zum Belüften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.</p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313868337">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251184">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251182">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN312324209">link</a></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mund-Nasen-Bedeckung</strong> -
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</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Mund-Nasen-Bedeckung (1), wobei die Mund-Nasen-Bedeckung (1) mindestens an einem Ohr eines Trägers magnetisch befestigbar ist.</p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313866760">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU311608060">link</a></p></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<li><a href="#from-new-yorker">From New Yorker</a></li>
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<li><a href="#from-vox">From Vox</a></li>
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<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
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<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
|
||||||
|
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
|
||||||
|
<li><a href="#from-ars-technica">From Ars Technica</a></li>
|
||||||
|
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
|
||||||
|
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Start your day with our new, bite-sized podcasts, Vox Quick Hits</strong> -
|
||||||
|
<figure>
|
||||||
|
<img alt="" src="https://cdn.vox-cdn.com/thumbor/iNIjqtbZ2RHnieJDyQeqbR5v7D8=/102x0:1719x1213/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68688006/VoxQuickHits_Lede.0.jpg"/>
|
||||||
|
<figcaption>
|
||||||
|
Zac Freeland/Vox
|
||||||
|
</figcaption>
|
||||||
|
</figure></li>
|
||||||
|
</ul>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Vox Quick Hits cover the big, important topics in news, politics, and pop culture in just a fraction of the time.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZkdP1p">
|
||||||
|
2020 took one look at my podcast listening habits, laughed maniacally, and tore them to shreds. My commute disappeared, along with my gym membership and planned travel. I no longer had time to kill while making my way to an appointment, friend’s place, bar, restaurant, or movie theater.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x9lM8B">
|
||||||
|
More critically, my brain started to short-circuit in March, fried from the deluge of news and stress and the blurring boundary between work and home life. I rarely had the mental capacity, let alone the time, for a 30- or 60-minute podcast. Listening started to feel more like a chore than a respite, which was a problem. And I’m willing to bet you’ve felt the same way.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Lk6FfE">
|
||||||
|
Luckily for me (and you, if this made you think “same”), Vox now has something to help with this exact problem: <a href="https://podcasts.apple.com/us/podcast/vox-quick-hits/id1549029999">Vox Quick Hits.</a>
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WNU0ww">
|
||||||
|
Vox Quick Hits isn’t a traditional podcast, but rather a <em>playlist</em><strong> </strong>where you can hear a mix of short episodes from Vox podcasts you know and love, plus some brand-new series. You’ll get the concise yet deep explanations you need on everything from Biden’s first 100 days in office to the best Netflix binge-watch.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OS2tyM">
|
||||||
|
Episodes are 10 minutes or less — perfect for squeezing into those random pockets of free time in your day. Three new episodes arrive in the Vox Quick Hits playlist each morning<em>, Monday through Friday. <em>(</em>Except for Tuesdays, which will typically have two new episodes.)</em>
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rp2Skq">
|
||||||
|
Your interests vary, so the types and topics of podcasts in your day-to-day lineup will too. But episodes will always arrive in this order:
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9zsOCJ">
|
||||||
|
First, the most important news story of the day from <em>Today, Explained</em>.
|
||||||
|
</p>
|
||||||
|
<div id="3nZSD1">
|
||||||
|
|
||||||
|
</div>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y0uLzO">
|
||||||
|
Next, an update on politics and policy.
|
||||||
|
</p>
|
||||||
|
<div id="EbR2pr">
|
||||||
|
|
||||||
|
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|
||||||
|
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|
||||||
|
|
||||||
|
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|
||||||
|
<div id="SZchbv">
|
||||||
|
|
||||||
|
</div>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mZ1YLV">
|
||||||
|
And the last episode will either cover pop culture or consumerism ...
|
||||||
|
</p>
|
||||||
|
<div id="uL3RlY">
|
||||||
|
|
||||||
|
</div>
|
||||||
|
<div id="a9EQfU">
|
||||||
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|
||||||
|
</div>
|
||||||
|
<div id="fXYYJh">
|
||||||
|
|
||||||
|
</div>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gBRWYO">
|
||||||
|
... or recommend your next book or binge-watch.
|
||||||
|
</p>
|
||||||
|
<div id="8zqDoS">
|
||||||
|
|
||||||
|
</div>
|
||||||
|
<div id="a16ECx">
|
||||||
|
|
||||||
|
</div>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YlL0dY">
|
||||||
|
You can find Vox Quick Hits and <a href="https://cms.megaphone.fm/channel/VMP3393546001?selected=VMP1125172927">subscribe in all the usual podcast places</a>. If you’re more of a smart-speaker person, you can find us on Google Nest and Home speakers, too. Just say: “Hey/Okay, YOU KNOW WHO, play the Vox Quick Hits podcast.”)
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BVi9z5">
|
||||||
|
Want more bite-sized content from Vox? <a href="https://www.vox.com/recode-daily-podcast"><em>Recode Daily</em></a>, hosted by senior reporter Teddy Schleifer, focuses on the most important Silicon Valley people, businesses, and stories that are influencing the rest of the world. Hear a new episode each day, always 10 minutes or less, wherever you listen to podcasts — including<strong> </strong><a href="https://podcasts.apple.com/us/podcast/reset/id1479107698">Apple Podcasts</a>, <a href="https://podcasts.google.com/?feed=aHR0cHM6Ly9yc3MuYXJ0MTkuY29tL3Jlc2V0">Google Podcasts</a>, and <a href="https://open.spotify.com/show/4UymEg74pIuiiLZTROIx4w?si=ECmLERE4QVK14VdsytEVDw">Spotify</a>.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tUNs4V">
|
||||||
|
May your brain feel less fried and more informed in 2021.
|
||||||
|
</p>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The best $1 I ever spent: A Venmo payment to my ex</strong> -
|
||||||
|
<figure>
|
||||||
|
<img alt="A phone with Venmo displayed" src="https://cdn.vox-cdn.com/thumbor/BruWcJKMXwFyhpq2NZFm8aGe6yI=/500x0:3500x2250/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68687969/Venmo.0.jpg"/>
|
||||||
|
<figcaption>
|
||||||
|
Dana Rodriguez for Vox
|
||||||
|
</figcaption>
|
||||||
|
</figure></li>
|
||||||
|
</ul>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
After I cut off communication, there was still one compartmentalized way for us to talk.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DUfsvM">
|
||||||
|
It was the end of August when I decided to Venmo my ex. We hadn’t spoken in weeks, and we hadn’t had a real conversation in months. It had been weeks because I blocked him on every platform I could. It had been months because most of our prior communication was one-sided and dripping with vitriol.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0ypRNb">
|
||||||
|
Today, though, I had a request. I needed him to return the internet router, which lived with him at my old apartment. He was moving, and if the router wasn’t returned, I’d be charged $13 a month for the rest of my life. I was just settling into a freedom from his constant pings and was reluctant to reach out — but my sanity in exchange for monthly payments forever seemed steep. Instead, I opened Venmo and sent $1, coupled with a request to “plz plz” return the router to Optimum. He did.
|
||||||
|
</p>
|
||||||
|
<hr class="p-entry-hr" id="QROVeO"/>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ad5w3u">
|
||||||
|
It was March when we broke up, a drawn-out process that lasted weeks and lives in my mind now as this dark, muddy thing. Mostly what I remember is it being cold, then warm. It was cold when I read his messages and then kicked the table and sliced my shin and cried and then went for a run. I laid in the park until the sun had set and both the grass and I had frosted over.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KBzGil">
|
||||||
|
The day I moved out it was warm, and sweat beaded on my neck and face as I carried my things from the U-Haul to my new apartment. I didn’t realize it then, but it was the first day of spring.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OtMYAk">
|
||||||
|
It’s impossible to talk about my breakup without talking about the pandemic. New York got bad early but it worked out for me because no one could tell I was crying underneath sunglasses and a face mask. As the rest of the city ordered latex gloves and sanitized their groceries, I tried to scrub the past from my present. I sliced our joint credit card with sewing scissors. I stopped sharing my location and deleted messages. I asked him, told him, begged him to stop texting me. He didn’t.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b3SD9f">
|
||||||
|
I learned early on that my romantic relationships do not easily translate to friendships. I don’t like mess, and I struggle to compartmentalize. I cannot let a person I once loved seep into the pockets of my new life, the ones I have thoughtfully carved out and filled with things that bring me comfort. It’s a practice in forgetting, and once you emerge from the blurriness of survival mode, the space that once fit this person so perfectly has shrunk. We weren’t meant to inhabit spaces so small.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L0vg4u">
|
||||||
|
My ex, on the other hand, did everything he could to keep that space from closing. Instead of giving me time and distance, he sent daily reminders of his existence. It started with a restrained kindness — a photo he’d taken of me walking down the street, smiling and lighting a cigarette; a message saying he missed me; a job opening he thought I’d be good for. Then he was vindictive and petty. He told me he was doing great. Fantastic! Thriving without me. Sometimes he questioned if we had made the right decision in breaking up. I was frantic and weak from these constant pinpricks.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hJ5vry">
|
||||||
|
Be gentle with yourself, friends and family told me when I shamefully admitted how much I had been drinking, how little I had been reading. Like gentleness and indulgence are the same.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J5R95S">
|
||||||
|
Many months in and right on schedule, his texts turned mean, and then they got meaner — the ugliest words anyone has ever sent me by way of little grey bubbles. I could barely reckon with the fact that this person had loved me, that my mom had given him her grandmother’s engagement ring. I tried to make sense of his words. An expression of anger was ultimately an expression of love, of caring, of falling apart, that’s what people told me. But meanness has never been a language I speak easily, and I was tired of interpreting. If there were any hope of salvaging even a cordial relationship, his last few texts sewed that space tightly shut.
|
||||||
|
</p>
|
||||||
|
<hr class="p-entry-hr" id="FFwsJs"/>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nRhRWP">
|
||||||
|
Blocking him across nearly every mode of communication felt like long-overdue liberation, and a feat for me, someone who doesn’t like absolutes. I was thorough in the job, too. I blocked him on Instagram and Twitter, and I banished his email addresses. I blocked his phone number from my phone and then a half-hearted apology slithered onto my laptop so I blocked him there too. A digital upheaval with only one tie left unsevered. <em> </em>
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vl7RKX">
|
||||||
|
When I tell someone that I only communicate with my ex on Venmo they usually laugh, because it’s actually very funny. I look at my feed and see tropical drink emojis and friends paying each other alongside inside jokes. It’s not a place for begrudging exes, but here we are.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B6gz7y">
|
||||||
|
A few months after I instigated our new means of communication, he adopted the tactic. I received an unexpected alert one day in which he informed me that my health insurance would be expiring. For this information, he offered a dollar.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G9ehpk">
|
||||||
|
Over the course of three years, my boyfriend and I had had many Venmo exchanges. Settling up on groceries, reimbursing for margaritas, paying half the rent. We turned to the app early in our breakup as well. He paid me for the furniture he sold, the table and credenza I had bought and assembled. But this was different — a step back, a renegotiation.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R0OQqb">
|
||||||
|
It’s not something I often strive to do, flatten someone into two dimensions so they fit snugly into a single app. But moving our relationship to a place that’s almost entirely transactional has tidied a messy breakup. Our new relationship thrives on Venmo, mostly because we barely speak. We are kind (I used a double “plz”), doling out dollars like olive branches. He respects my boundaries, boundaries bolstered by Venmo’s capabilities and limitations, and in turn, has access to me in case of emergency.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S6fJGe">
|
||||||
|
With one payment of a single dollar, I drew a line that I have yet to move and he has yet to cross. My reward is some much-needed quiet.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fRcyJJ">
|
||||||
|
Since March, like many others, my days have become slower, quieter. I stand in my kitchen each morning, waiting for coffee to brew, as my neighbor lets three petite dogs into his front yard. I’ve watched the tree outside my bedroom window transform from a bare wisp, to a lush green giant, to a weeping, fiery thing, and back again. Some things have to stay the same in order for us to realize how much others change. I don’t know when it happened, but my life got bright again.
|
||||||
|
</p>
|
||||||
|
<p class="c-end-para" data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k26ClQ">
|
||||||
|
I have two cats. We used to share them but now they’re mine. Lately, Coconut, who’s always been skittish and independent, cuddles with me every night and every morning. For a moment I think of sending a payment to tell my ex about this new development; no one else would appreciate it in quite the same way. But I stop myself, feeling silly. I don’t want to make a mess.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NOsBAJ">
|
||||||
|
<a href="https://www.rachelellison.net/"><em>Rachel Ellison</em></a><em> is a writer living in Brooklyn. Her work has appeared in The Guardian and HuffPost. </em>
|
||||||
|
</p>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Natural immunity after Covid-19 could last at least 5 months</strong> -
|
||||||
|
<figure>
|
||||||
|
<img alt="" src="https://cdn.vox-cdn.com/thumbor/ixS6EAtbGcSblT_iWVoQ6m4-j_M=/343x0:4356x3010/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68672647/1289423565.0.jpg"/>
|
||||||
|
<figcaption>
|
||||||
|
A transmission electron microscope image shows SARS-CoV-2, the virus that causes Covid-19. | Image Point FR/NIH/BSIP/Universal Images Group via Getty Images
|
||||||
|
</figcaption>
|
||||||
|
</figure></li>
|
||||||
|
</ul>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
There’s some good news for those who’ve already been infected with the coronavirus.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KGiisw">
|
||||||
|
For the <a href="https://coronavirus.jhu.edu/">nearly 100 million</a> people around the world who’ve been <a href="https://www.vox.com/coronavirus-covid19">infected with the coronavirus</a>, new science offers some comfort: Reinfections appear to be rare, and you may be protected from Covid-19 for at least five months.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NRapVQ">
|
||||||
|
The <a href="https://www.medrxiv.org/content/10.1101/2021.01.13.21249642v1">study</a>, the largest of its kind, followed more than 20,000 health workers in the UK, regularly testing them for infection and antibodies. Between June and November, the researchers — from <a href="https://www.gov.uk/government/news/past-covid-19-infection-provides-some-immunity-but-people-may-still-carry-and-transmit-virus">Public Health England</a> (PHE) — found 44 potential reinfections out of the 6,614 participants who had tested positive for antibodies or had a previous positive PCR or antibody test when they joined the study. Meanwhile, of the 14,000-plus people who had tested negative for the virus at the start of the study, there were 409 new infections.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tt8yu2">
|
||||||
|
Only two of the 44 potential reinfections were designated “probable” and the rest were considered “possible,” “based on the amount of confirmatory evidence available,” the <a href="https://www.gov.uk/government/news/past-covid-19-infection-provides-some-immunity-but-people-may-still-carry-and-transmit-virus">health agency</a>. Fifteen people — or 34 percent — had symptoms.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="piDiE6">
|
||||||
|
So if all 44 reinfections are real, that translates to an 83 percent lower risk of reinfection compared to health workers who never had the virus. If only two are confirmed, that rate of protection goes up to 99 percent. Either way, it suggests natural immunity might provide a similar level of <a href="https://www.ft.com/content/929ef3cd-8611-49b2-9f23-918dc3470166">protection as the approved Covid-19 vaccines</a>.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DFARZp">
|
||||||
|
But as with the vaccines, it’s not yet clear how long immunity after an infection lasts. Antibodies may fade after five months or last much longer, something the researchers behind the ongoing study, which will run for a total of 12 months, plan to investigate.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lgxoDn">
|
||||||
|
“This [new] study does provide some comfort that naturally acquired antibodies are pretty effective in preventing reinfections,” <a href="https://medicine.yale.edu/profile/akiko_iwasaki/">Akiko Iwasaki</a>, an immunobiologist at Yale University, told Vox. The findings also square with another paper on health workers, published in the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2034545"><em>New England Journal of Medicine</em></a> in December: Researchers found people who had Covid-19 antibodies were better protected from the virus for six months than people who did not.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gEaGy5">
|
||||||
|
That said, Iwasaki said, “You can also interpret these data to mean that protection against reinfection is not complete — especially for people who had Covid during the first wave, say in March-April 2020.”
|
||||||
|
</p>
|
||||||
|
<h3 id="PeE2N7">
|
||||||
|
People who had the virus may still be able to pass it on if reinfected
|
||||||
|
</h3>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2PNR6U">
|
||||||
|
The good news for individuals who have had Covid-19 also comes with a warning about the risk they can still pose to other people. While antibodies might protect against a second case of Covid-19 in most people, “early evidence from the next stage of the study suggests that some of these individuals carry high levels of virus and could continue to transmit the virus to others,” <a href="https://www.gov.uk/government/news/past-covid-19-infection-provides-some-immunity-but-people-may-still-carry-and-transmit-virus">PHE</a> warned in their press release.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Kw4GG3">
|
||||||
|
“We now know that most of those who have had the virus, and developed antibodies, are protected from reinfection, but this is not total,” Susan Hopkins, a senior medical adviser at PHE and the study lead, said in a statement, “and we do not yet know how long protection lasts.”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h9qXIc">
|
||||||
|
In other words, even if you’ve had Covid-19, while you’re unlikely to get really sick again anytime soon, you should still consider yourself a potential risk of spreading it to others if you catch the virus again and may be asymptomatic. That means continuing to take precautions — like <a href="https://www.vox.com/22220301/covid-spread-new-strain-variants-safe-grocery-store-n95-masks-vaccine">mask-wearing and social distancing</a>, Iwasaki added. And it’s one reason why immunologists have said people who’ve already been infected with the virus should <a href="https://www.vox.com/science-and-health/22179683/covid-19-vaccine-effective-people-had-coronavirus">still plan to get the vaccine</a> when their turn comes.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9mz3J9">
|
||||||
|
So there’s still a lot more to learn about immunity after Covid-19: How will the <a href="https://www.vox.com/22213033/covid-19-mutation-variant-vaccine-uk-south-africa">new coronavirus variants</a> of concern affect it? <a href="https://www.youtube.com/watch?v=9sdZmrfWRo0">Lab data from South Africa</a>, where the 501Y.V2 variant has been spreading, suggest it might be able to escape antibodies produced by prior infections in some people.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZYGzCW">
|
||||||
|
Who is most likely to have a strong immune response? We do have <a href="https://science.sciencemag.org/content/early/2021/01/06/science.abf4063">some evidence</a> that different individuals mount different antibody responses after Covid-19 infections, but the PHE researchers found no statistically significant difference in rates of protection between people who reported symptoms and those who did not. It’s also possible factors like gender and <a href="https://wwwnc.cdc.gov/eid/article/27/3/20-4543_article">disease severity</a> influence the strength of a person’s immune response.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vK2vJq">
|
||||||
|
For now, though, the research suggests that survivors of the virus might just help us get to herd immunity faster — if their immunity lasts long enough. But given the virus has only been known to humans for a little over a year, it may take a while to authoritatively answer the question.
|
||||||
|
</p>
|
||||||
|
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Historic moment: Pawar on India's win in Test against Australia</strong> - NCP chief Sharad Pawar on Tuesday congratulated the Indian cricket team for its "fabulous" victory against Australia in the fourth and final Test matc</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Olympic champion charged in weightlifting doping case</strong> - Weightlifting's widespread doping and corruption issues were exposed one year ago by German broadcaster ARD.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Learnt a lesson from the series, never ever underestimate India: Langer</strong> - “It’s gonna hurt us big time. India deserved full credit. They have been outstanding but we have learnt lessons from it,” Australia head coach Justin Langer said</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nothing surpasses this, after 36 all out, this is unreal: Shastri</strong> - Shastri also said that the just-concluded series was the toughest tour ever for him.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>BCCI announces ₹5 crore bonus for triumphant Indian team</strong> - The BCCI on January 19 announced a ₹5 crore bonus for the Indian cricket team after the Ajinkya Rahane-led side won the fourth and final Test against</p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBI recovers ₹2.04 crore cash hidden in South Delhi hotel in railway officials bribery case</strong> - The agency had arrested Chief Administrative Officer MS Chauhan of NFR and other senior officials in the case involving a bribe amount of ₹1 crore</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Yamuna: Supreme Courts asks Centre, Haryana to make submissions</strong> - Both blame Delhi for pollution levels in the river</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Providing official secret info to journalist ‘criminal act’: Rahul Gandhi on purported Arnab chats</strong> - “Giving official secret information to a journalist is a criminal act, both on the part of the person who accepted it and on the part of the person who gave it,” he said.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Number of people vaccinated against COVID-19 more than double number of active cases: Health Ministry</strong> - Daily new cases touched a new low on Jan. 19 with 10,064 daily new infections being added to the national tally after seven months</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indian military personnel for Moscow soon for S-400 training</strong> - India prepares to receive first batch of the long-range air defence system by year-end</p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
||||||
|
<ul>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Italy PM Conte faces crucial Senate vote to stay in power</strong> - The vote in Italy's upper house was triggered by a row over EU funds to tackle Covid.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ONA: Vegan restaurant becomes first in France to get Michelin star</strong> - ONA in the south-west is the first eatery serving plant-based food to win a prestigious Michelin star.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Alexei Navalny: Poisoned Putin critic Navalny to be kept in custody</strong> - It follows his dramatic return to Russia, five months after a nerve agent attack almost killed him.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Olivier Duhamel: French incest allegations prompt victims to speak out</strong> - A sex abuse case involving a well-known intellectual sparked a deluge of testimonies by victims of abuse.</p></li>
|
||||||
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Italy smoking: Want to light up in Milan? Not any more, you can't</strong> - Smoking within 10m (30ft) of others is no longer allowed in parks, play areas, bus and tram stops.</p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
|
||||||
|
<ul>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hitman III review: Let’s call it Hitman 2.5 and be fine with it</strong> - This sequel's lack of ambition will likely reinforce your murderous bias. - <a href="https://arstechnica.com/?p=1735723">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wi-Fi 6E arrives at CES 2021</strong> - We roundup the Wi-FI 6E routers, with Asus' model is launching as soon as this month. - <a href="https://arstechnica.com/?p=1735460">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Parler seems to be sliding back onto the Internet, but not onto mobile</strong> - Parler is following a path laid for it by the likes of Gab and 8chan. - <a href="https://arstechnica.com/?p=1735762">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Report: This year’s iPhones may have in-screen Touch ID</strong> - Also, the charging port might be retired. - <a href="https://arstechnica.com/?p=1735817">link</a></p></li>
|
||||||
|
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Scientists surprised to find that electric eels sometimes hunt in packs</strong> - Discovery raises fresh questions about how the eels communicate. - <a href="https://arstechnica.com/?p=1735608">link</a></p></li>
|
||||||
|
</ul>
|
||||||
|
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
|
||||||
|
<ul>
|
||||||
|
<li><strong>Translated from German, I hope this works: What’s 3x3?</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
No
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/OB1KENOB"> /u/OB1KENOB </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l0b9sm/translated_from_german_i_hope_this_works_whats_3x3/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l0b9sm/translated_from_german_i_hope_this_works_whats_3x3/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>Queen Elizabeth and Dolly Parton die on the same day and they both go before an Angel to find out if they'll be admitted to Heaven</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Unfortunately, there's only one space left that day, so the Angel must decide which of them gets in.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The Angel asks Dolly if there's some particular reason why she should go to Heaven.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Dolly takes off her top and says, 'Look at these, they're the most perfect breasts God ever created, and I'm sure it will please God to be able to see them every day, for eternity.'
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The Angel thanks Dolly, and asks Her Majesty the same question. The Queen takes a bottle of Perrier out of her purse, drinks it down. Then, pees into a toilet and pulls the lever.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The Angel says, 'OK, your Majesty, you may go in.'
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Dolly is outraged and asks, 'What was that all about?
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
I show you two of God's own perfect creations and you turn me down. She pees into a toilet and she gets in!
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
'Sorry, Dolly,' says the Angel, 'but even in Heaven, A Royal Flush beats a Pair. no matter how big they are.
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Almighty_Egg"> /u/Almighty_Egg </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l034rt/queen_elizabeth_and_dolly_parton_die_on_the_same/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l034rt/queen_elizabeth_and_dolly_parton_die_on_the_same/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>A Jew, a Muslim, and a Jehovah's Witness were driving through the countryside when their car broke down.</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The only house in the vicinity was an old farmhouse, so they decided to stay there for the night.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
"I'm so sorry," said the farmer. "The bed in the guest room only has room for two people." So he volunteered the Jew to sleep in the barn.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Five minutes later, the farmer heard a knock on the door. He opened the door, and there was the Jew.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
"What are you doing here?" asked the farmer.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
"I'm afraid I cannot sleep in the barn because there is a pig in the barn, and my religion considers pigs to be unclean animals."
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
"Very well," said the farmer. "You can sleep in the guest room." And he volunteered the Muslim to sleep in the barn.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Five minutes later, the farmer heard a knock on the door. He opened the door, and there was the Muslim.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
"What are you doing here?" asked the farmer.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
"I'm afraid I cannot sleep in the barn because there is a pig in the barn, and my religion considers pigs to be unclean animals."
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
"Very well," said the farmer. "You can sleep in the guest room." And he volunteered the Jehovah's Witness to sleep in the barn.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Five minutes later, the farmer heard a knock on the door. He opened the door, and there was the pig.
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/wimpykidfan37"> /u/wimpykidfan37 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l07kq5/a_jew_a_muslim_and_a_jehovahs_witness_were/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l07kq5/a_jew_a_muslim_and_a_jehovahs_witness_were/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>Why did the Proud Boy check on his sad friend?</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
To make sure his friend was feeling... alt-right.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Feel free to downvote me to reddit hell...
|
||||||
|
</p>
|
||||||
|
</div>
|
||||||
|
<!-- SC_ON -->
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/T-Rex_Mullens"> /u/T-Rex_Mullens </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kzxnwp/why_did_the_proud_boy_check_on_his_sad_friend/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kzxnwp/why_did_the_proud_boy_check_on_his_sad_friend/">[comments]</a></span></p></li>
|
||||||
|
<li><strong>3 brothers enter the hospital room of their dying parents who have lived a long life of exploring and treasure hunting.</strong> - <!-- SC_OFF -->
|
||||||
|
<div class="md">
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Their parents greet them, and tell them of the last adventure they were unable to complete. “There’s a cave down in South America, deep in the jungles of Brazil. Go there and find the treasure we have been searching for the last 20 years. We know the three of you will find it.”
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The brothers leave to prepare for their journey, their hearts heavy from their parents passing, but set with vindictive courage determined to find this mysterious cave.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
3 years later the brothers are hopeless, having found no evidence of such a cave in the Brazilian jungles. They make it back to their parents house eventually... where they find a little glass bottle on top of the fridge, with a scroll rolled up inside.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The first brother uncorks the bottle and gets the scroll out, starting to unroll it. <em>crinkle crinkle</em> The paper is very brittle.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
On it reveals a clear path through Brazil to where this mysterious cave might be. They only wish they knew about this treasure map 3 years ago... but alas, their journey begins.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Finally, within the Brazilian forests they arrive at the steps of a vine-encased stairway surrounded by foliage. There is no sign or anything, but this is where their parents’ treasure map led them to.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The brothers take each other by hand and begin to descend. After what seems like 1,000 steps they finally reach a dim torch-lit room with three doors. One door has a fire symbol. One door has a water symbol. And the last door has a question mark.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
Bewildered by these symbols the first brother decides to take one for the team and enters the fire door. It slams behind him as he descends another 1,000 stairs. Finally reaching the bottom he finds red Rubies scattered about the floor in piles he could never have imagined! He begins gathering rubies into sacks he brought and once he picks up the last ruby.. he notices a fireball start to form in the corner of the room. So he lifts his sacks in an adrenaline-fueled rush and bee-lines it for the door, 1,000 stairs up. He just barely makes it out, slamming the door on the fireball behind him.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
His brothers are impressed by his riches that he gathered! While also afraid that the fire door housed a killer fireball. But the second brother can’t be outdone by the first.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
He makes his way down the stairs of the water symbol door. Making it to the bottom of the steps he finds sapphires scattered everywhere and begins to gather them up. He picks up the last sapphire and water immediately begins seeping in from all corners of the room... In a rushed panic he picks up his sacks of sapphires and trudges through the water, barely making it up the stairs and closing the door before the water level rose enough to kill him and his brothers.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
The third brother is now wildly impressed with his first two brothers’ riches! And also terrified to open this third door and see what evils may linger behind a question mark symbol.
|
||||||
|
</p>
|
||||||
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||||
|
He gathers up some courage and enters. This time there are only 10 steps. He finds rubies, sapphires, emeralds, and diamonds galore! There are so many treasures he fills up 4, 5, 6 enormous sacks of gems and.. nothing happens. He picks up his treasures and barely manages to make it up those 10 steps with all the extra weight.
|
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</p>
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His brothers are ASTOUNDED. How did you get all that treasure?! Why did nothing attack YOU?!
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</p>
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Nevertheless, the boys returned home with their respective treasures, feeling fulfilled by completing their parents goal.
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</p>
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The first brother celebrates by buying a nice house on a lake in Texas, getting all sorts of fun toys and things to play with considering his newfound fortune. Years go by, and one day there is a gas leak in his kitchen. As he leans in to examine the issue, a fireball explodes in his face and kills him in a fiery death.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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The very same day years later, the second brother was out enjoying a margarita on the beach, in front of his new beach mansion. Those sapphires really paid off for him to live a stress free life! That is until a tsunami forms faster than ever and engulfs the beach, claiming the second brother’s life before he or his margarita knew it.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Now the third brother hears about the tragic deaths of his brothers.. and recalls the fire door, and the water door which relate to his brothers’ deaths. Since he doesn’t know what to expect he begins to prepare for the worst. As he had saved his jewels and not lived an extravagant lifestyle the past few years, he had plenty of wealth to invest in a castle with a drawbridge and an alligator moat. An entire team of armed guards was set up for 24 hour lookout and protection.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Weeks go by and there is no cause for any alarm. Until one day where he gets a dispatch on his Walkie-talkie, “Psshhhhk- hello sir, you may want to have a look at this.. uh, I’m not sure how else to describe it. We have identified a.. floating coffin? It seems to be headed in our direction at a steady pace.. just ominously floating.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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The brother immediately heads to the lookout tower to get a glimpse through binoculars. And then he sees it. The floating coffin has a big question mark on the front of it.. floating directly towards him 1,000 meters away. He immediately recognizes this as the question mark on the door where he found his treasures.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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In a panic, he yells into his walkie talkie, “Psshhhk- ATTENTION ALL GUARDS, DO NOT LET THAT THING INTO THIS CASTLE. OPEN FIRE, RAISE THE DRAWBRIDGE! DO ANYTHING YOU HAVE TO DO TO PROTECT ME!!”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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He then makes his way to the deepest, most secluded portion of his castle, ending up in a guest bathroom underground where he was holed up waiting for his fate to arrive.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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His guards radio in as he starts to hear rumbling and crashing upstairs above him.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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“Psshhhk- SIR! Sir.. we can’t stop it. Our bullets just bounce off of it! It just floated over the moat and crashed through our drawbridge!! It is coming for you.. we can———“ and the walkie falls silent.
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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In a panic the brother starts to look for anything he might be able to use to defend himself... he really is at a disadvantage in this guest bathroom as all he can find is an old rusty razor and a bottle of NyQuil. He thinks just maybe he could try and slice at it with the razor and maybe use the bottle of NyQuil as a projectile.
|
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Soon enough, he hears the coffin crashing through the outer door, and CRASH the bathroom door shatters into pieces as the big question mark fills his view. Quickly, he throws the bottle of NyQuil and lunges at the coffin with the razor in hand... but he swings at nothing.. the coffin had vanished into thin air as soon as the NyQuil made contact.
|
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|
</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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And that’s when he realized.. NyQuil stops the coffin.
|
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|
</p>
|
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</div>
|
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<!-- SC_ON -->
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|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/PigzOnReddit"> /u/PigzOnReddit </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l05pzg/3_brothers_enter_the_hospital_room_of_their_dying/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l05pzg/3_brothers_enter_the_hospital_room_of_their_dying/">[comments]</a></span></p></li>
|
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|
</ul>
|
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<script>AOS.init();</script></body></html>
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Reference in New Issue