diff --git a/archive-covid-19/19 April, 2023.html b/archive-covid-19/19 April, 2023.html new file mode 100644 index 0000000..c61e4d0 --- /dev/null +++ b/archive-covid-19/19 April, 2023.html @@ -0,0 +1,188 @@ + +
+ + + ++Objectives: Cancer treatments were variably disrupted during the COVID-19 pandemic. UK guidelines recommend pancreatic enzyme replacement therapy (PERT) to all people with unresectable pancreatic cancer. The aim was to investigate the impact of COVID-19 on PERT prescribing to people with unresectable pancreatic cancer and to investigate the national and regional rates from January 2015 to January 2023. Data sources: With the approval of NHS England, we conducted this study using 24 million electronic healthcare records of people within the OpenSAFELY-TPP research platform. There were 22,860 people diagnosed with pancreatic cancer in the study cohort. We visualised the trends over time and modelled the effect of COVID-19 with the interrupted time series analysis. Conclusions: In contrast to many other treatments, prescribing of PERT was not affected during the pandemic. Overall, since 2015, the rates increased steadily over time by 1% every year. The national rates ranged from 41% in 2015 to 48% in early 2023. There was substantial regional variation with the highest rates of 50% to 60% in West Midlands. Implications for Nursing Practice: In pancreatic cancer, if PERT is prescribed, it is usually initiated in hospitals by clinical nurse specialists and continued after discharge by primary care. At just under 50% in early 2023, the rates were still below the recommended 100% standard. More research is needed to understand barriers to prescribing of PERT and geographic variation to improve quality of care. Prior work relied on manual audits. With OpenSAFELY, we developed an automated audit allowing for regular updates. +
++COVID-19 has impacted all areas of life, with lasting effects on physical, mental, and societal health. Specifically, COVID and related losses have exacerbated prolonged grief responses and mental disorders including depression and anxiety. These mental health concerns are associated with increased detrimental coping strategies including substance use. In this study, we analyzed secondary data from the National Survey on Drug Use and Health (NSDUH) collected during the COVID-19 pandemic. Our results showed a positive association between serious psychological distress and marijuana use, while frequent religious service attendance acted as a moderator in this relationship. Individuals involved in communal religious activity were less likely to use marijuana. This study highlights the impact of religion and faith in bringing hope and purpose during periods of loss, coping with stress, grief, mental health challenges, and substance use. +
++A new mathematical method with an outstanding potential to predict the incidence of COVID-19 diseases has been proposed. The model proposed is an improvement to the SEIR model. In order to improve the basic understanding of disease spread and outcomes, four compartments included presymptomatic, asymptomatic, quarantine hospitalized and hospitalized. We have studied COVID-19 cases in the city of Mumbai. We first gather clinical details and fit it on death cases using the Lavenberg-Marquardt model to approximate the various parameters. The model uses logistic regression to calculate the basic reproduction number over time and the case fatality rate based on the age-category scenario of the city of Mumbai. Two types of case fatality rate are calculated by the model: one is CFR daily, and the other is total CFR. The total case fatality rate is 4.2, which is almost the same as the actual scenario. The proposed model predicts the approximate time when the disease is at its worst and the approximate time when death cases barely arise and determines how many hospital beds in the peak days of infection would be expected. The proposed model outperforms the classic ARX, SARIMAX and the ARIMA model. And It also outperforms the deep learning models LSTM and Seq2Seq model. To validate results, RMSE, MAPE and R squared matrices are used and are represented using Taylor diagrams graphically. +
++Human saliva contains a plethora of proteins whose presence and concentration can be monitored for diagnosis and progression of disease. Saliva has been extensively probed for the diagnosis of several systemic and infectious diseases because of the ease with which it can be collected. However, amylase, the most abundant protein found in saliva can obscure the detection of low-abundance proteins by MALDI-ToF MS (matrix-assisted laser desorption/ionization-time of flight mass spectrometry) and diminish the diagnostic utility of this specimen type. In the present study, we used a device to deplete salivary amylase from water-gargle samples through affinity adsorption. After depletion, profiling of the saliva proteome was performed by MALDI-ToF MS on gargle samples from subjects whose COVID-19 (coronavirus disease 2019) status was confirmed by NP (nasopharyngeal) swab RT-qPCR (reverse transcription polymerase chain reaction). Amylase depletion led to the enhancement of signal intensities of various peaks as well as the detection of previously unobserved peaks in the MALDI-ToF spectra. The overall specificity and sensitivity after amylase depletion was 100% and 85.17% respectively for detecting COVID-19. Our simple, rapid and inexpensive technique to deplete salivary amylase can be used to unmask spectral diversity in saliva by MALDI-ToF MS, reveal low-abundant proteins and aid in the establishment of novel biomarkers for diseases. +
++Abstract: Fever is a recognized protective factor in patients with sepsis, and growing data suggest beneficial effects on outcomes in sepsis with elevated temperature, with a recent pilot randomized controlled trial showing lower mortality by warming afebrile sepsis patients in the intensive care unit. The objective of this prospective single-site randomized controlled trial was to determine if core warming improves respiratory physiology of mechanically ventilated patients with COVID-19, allowing earlier weaning from ventilation, and greater overall survival. A total of 19 patients with mean age of 60.5 (±12.5) years, 37% female, mean weight 95.1 (±18.6) kg, and mean BMI 34.5 (±5.9) kg/m2 with COVID-19 requiring mechanical ventilation were enrolled from September 2020 through February 2022. Patients were randomized 1:1 to standard-of-care or to receive core warming for 72 hours via an esophageal heat exchanger commonly utilized in critical care and surgical patients. The maximum target temperature was 39.8 °C. A total of 10 patients received usual care and 9 patients received esophageal core warming. After 72 hours of warming, PaO2/FiO2 ratios were 197 (±32) and 134 (±13.4), Cycle Thresholds were 30.8 (±6.4) and 31.4 (±3.2), ICU mortality was 40% and 44%, 30-day mortality was 30% and 22%, and mean 30-day ventilator-free days were 11.9 (±12.6) and 6.8 (±10.2) for standard-of-care and warmed patients, respectively (p=NS). This pilot study suggests that core warming of patients with COVID-19 undergoing mechanical ventilation is feasible and appears safe. Optimizing time to achieve febrile-range temperature may require a multimodal temperature management strategy to further evaluate effects on outcome. +
++Introduction: Development of drug prescription skills poses critical challenges in medical education. This study determined the effects of simulated interviews on the improvement of drug prescription skills among medical students in 2020. Methodology: This was a quantitative, cross-sectional, analytical, quasi-experimental study of simulated interviews for improving rational drug prescription skills in medical students. Baseline, pre-, and post-intervention assessments of prescription skills were performed using an expert-validated instrument constructed from the WHO Good Prescribing Guide. Three simulated interviews with different simulated patients were conducted in two groups: in-person in the first batch and remotely in the second batch due to mandatory social distancing during the Covid-19 pandemics. Friedman, Dunn-Bonferroni, and Wilcoxon tests were used, considering a significance of level p<.05 and standardized mean difference (Hedges g); data were analyzed using Excel 2016 and SPSS 28. Results: Fifty-four students completed the required assessments; in-person 28 and remotely 26. The total score for pharmacological prescription skills increased significantly from pre- to post-intervention measurements, from 12.72 +/- 2.94 to 15.44 +/- 2.50, respectively (p<.0001) (g: 0.996), and the increase from baseline to post-intervention scores for drug prescription knowledge was 5.39 +/- 3.67, 11.28 +/- 3.50, respectively (p <.01). Discussion: Our results suggest that the implementation of pre-briefing and debriefing strategies in remote and in-person clinical interviews with simulated patients significantly improved drug prescription skills and pharmacological knowledge among medical students. The logical sequence of the WHO Guide for Good Prescribing may have facilitated debriefing, knowledge acquisition, and transfer to various clinical contexts. +
++Patients with hypoplastic left heart syndrome who have been palliated with the Fontan procedure are at risk for adverse neurodevelopmental outcomes, lower quality of life, and reduced employability. We describe the methods (including quality assurance and quality control protocols) and challenges of a multi-center observational ancillary study, SVRIII (Single Ventricle Reconstruction Trial) Brain Connectome. Our original goal was to obtain advanced neuroimaging (Diffusion Tensor Imaging and Resting-BOLD) in 140 SVR III participants and 100 healthy controls for brain connectome analyses. Linear regression and mediation statistical methods will be used to analyze associations of brain connectome measures with neurocognitive measures and clinical risk factors. Initial recruitment challenges occurred related to difficulties with: 1) coordinating brain MRI for participants already undergoing extensive testing in the parent study, and 2) recruiting healthy control subjects. The COVID-19 pandemic negatively affected enrollment late in the study. Enrollment challenges were addressed by 1) adding additional study sites, 2) increasing the frequency of meetings with site coordinators and 3) developing additional healthy control recruitment strategies, including using research registries and advertising the study to community-based groups. Technical challenges that emerged early in the study were related to the acquisition, harmonization, and transfer of neuroimages. These hurdles were successfully overcome with protocol modifications and frequent site visits that involved human and synthetic phantoms. +
++Intranasal sprays containing Bacillus species are being researched for treating viral respiratory tract infections. The aim of this study was to assess the relationship between the nasal carriage of Bacillus and COVID-19 severity. This was a cross-sectional study that collected nasopharyngeal samples from adults 18 years and above visiting two COVID-19 testing centers in Lagos, Nigeria between September 2020 and September 2021. Bacillus species were cultured from the respiratory samples and confirmed using molecular methods. The dependent variable was COVID-19 status classified as negative, asymptomatic, mild, or severe. The independent variable was the nasal carriage of Bacillus species. Multinomial regression analysis was done to determine the association between nasal carriage of Bacillus and COVID-19 severity after adjusting for age, sex, and co-morbidity status. About 388 participants were included in the study with a mean (standard deviation) age of 40.05 (13.563) years. The majority (61.1%) of the participants were male, 100 (25.8%) had severe COVID-19, 130 (33.5%) had pre-existing comorbidity, and 76 (19.6%) had Bacillus cultured from their nasopharyngeal specimen. Bacillus species presence was significantly associated with higher odds of severe COVID-19 compared to having a negative COVID-19 status. However, the presence of Bacillus species was significantly associated with lower odds of severe COVID-19 compared to having a mild COVID-19 status. The study suggests that nasal carriage of Bacillus species may substantially impact the clinical course of COVID-19. This study supports the exploration of Bacillus species in the prevention and management of viral respiratory tract infections. +
+Effectiveness and Safety of Quinine Sulfate as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia ( DEAL-COVID19 ) - Condition: COVID-19
Interventions: Drug: Standard of Care + Quinine Sulfate; Drug: Standard of Care
Sponsors: Universitas Padjadjaran; National Research and Innovation Agency of Indonesia; Prodia Diacro Laboratories P.T.
Recruiting
Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 - Condition: Long COVID-19 Syndrome
Intervention: Biological: MSC-derived exosomes
Sponsors: Huazhong University of Science and Technology; REGEN-αGEEK (SHENZHEN) MEDICAL TECHNOLOGY CO., LTD.
Recruiting
Efficacy and Safety of Nirmatrelvir/Ritonavir for Treating Omicron Variant of COVID-19 - Condition: Omicron Variant of COVID-19
Intervention: Drug: Nirmatrelvir/Ritonavir
Sponsor: Xiangao Jiang
Completed
A Nasal Treatment for COVID-19 - Condition: COVID-19
Interventions: Drug: Optate; Drug: Placebo
Sponsor: Indiana University
Not yet recruiting
A Study of mRNA-1283.222 Injection Compared With mRNA-1273.222 Injection in Participants ≥12 Years of Age to Prevent COVID-19 - Condition: COVID-19
Interventions: Biological: mRNA-1283.222; Biological: mRNA-1273.222
Sponsor: ModernaTX, Inc.
Recruiting
To Evaluate the Safety and Efficacy of Meplazumab in Treatment of COVID-19 Sequelae - Condition: COVID-19
Interventions: Biological: Meplazumab for injection; Other: Normal saline
Sponsor: Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd
Recruiting
Evaluation of the RD-X19 Treatment Device in Individuals With Mild COVID-19 - Condition: COVID-19
Interventions: Device: RD-X19; Device: Sham
Sponsor: EmitBio Inc.
Recruiting
Clinical Study for the Efficacy and Safety of Ropeginterferon Alfa-2b in Adult COVID-19 Patients With Comorbidities - Condition: COVID-19
Interventions: Drug: Ropeginterferon alfa-2b; Procedure: SOC
Sponsor: National Taiwan University Hospital
Not yet recruiting
Assessment of Immunogenicity, Safety and Reactogenicity of a Booster Dose of Various COVID-19 Vaccine Platforms in Individuals Primed With Several Regimes. - Condition: COVID-19
Interventions: Biological: SCB-2019/Clover; Biological: AstraZeneca/Fiocruz; Biological: Pfizer/Wyeth
Sponsors: D’Or Institute for Research and Education; Bill and Melinda Gates Foundation
Active, not recruiting
Postoperative Sugammadex After COVID-19 - Conditions: General Anesthesia; COVID-19
Interventions: Drug: Sugammadex Sodium; Drug: neostigmine 50µg/kg + glycopyrollate 0.01mg/kg
Sponsor: Korea University Ansan Hospital
Not yet recruiting
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) - Condition: COVID-19
Interventions: Drug: Azeliragon; Drug: Placebo
Sponsor: Salim S. Hayek
Recruiting
Tailored COVID-19 Testing Support Plan for Francophone African Born Immigrants - Condition: COVID19 Testing
Interventions: Behavioral: FABI tailored COVID-19 testing pamphlet; Behavioral: Standard COVID-19 home-based test kit
Sponsors: Texas Woman’s University; National Institutes of Health (NIH)
Not yet recruiting
A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not Hospitalized. - Condition: SARS-CoV-2 Infection
Interventions: Drug: PF-07817883; Drug: Placebo
Sponsor: Pfizer
Not yet recruiting
Cognitive-behavioral Therapy for Mental Disorder in COVID-19 Survivors - Condition: Post Acute COVID-19 Syndrome
Intervention: Behavioral: mindfulness-based stress reduction (MBSR) and cognitive behavioral therapy (CBT)
Sponsor: Azienda Socio Sanitaria Territoriale di Lecco
Recruiting
Efficacy of Lactobacillus Paracasei PS23 for Patients With Post-COVID-19 Syndrome - Condition: Post-COVID-19 Syndrome
Intervention: Dietary Supplement: PS23 heat-treated
Sponsors: Mackay Memorial Hospital; Bened Biomedical Co., Ltd.
Recruiting
Molecular Networking Accelerated Discovery of Biflavonoid Alkaloids from Cephalotaxus sinensis - Four undescribed biflavonoid alkaloids, sinenbiflavones A-D, were isolated from Cephalotaxus sinensis using a MS/MS-based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HRESIMS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A-D are the first examples of amentoflavone-type (C-3’-C-8’’) biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C-6-methylated amentoflavone-type biflavonoid alkaloids. Sinenbiflavone D showed weak…
Myeloperoxidase Inhibition in Heart Failure With Preserved or Mildly Reduced Ejection Fraction: SATELLITE Trial Results - CONCLUSIONS: AZD4831 inhibited myeloperoxidase and was well tolerated in patients with HF and LVEF ≥40%. Efficacy findings were exploratory due to early termination but warrant further clinical investigation of AZD4831.
Awareness raising and dealing with methanol poisoning based on effective strategies - Intoxication with methanol most commonly occurs as a consequence of ingesting, inhaling, or coming into contact with formulations that include methanol as a base. Clinical manifestations of methanol poisoning include suppression of the central nervous system, gastrointestinal symptoms, and decompensated metabolic acidosis, which is associated with impaired vision and either early or late blindness within 0.5-4 h after ingestion. After ingestion, methanol concentrations in the blood that are…
Ferrocenoyl-substituted quinolinone and coumarin as organometallic inhibitors of SARS-CoV-2 3CLpro main protease - The 3-chymotrypsin-like protease 3CLpro from SARS-CoV-2 is a potential target for antiviral drug development. In this work, three organometallic ferrocene-modified quinolinones and coumarins were compared to their benzoic acid ester analogues with regard to inhibition of 3CLpro using a HPLC-based assay with a 15mer model peptide as the substrate. In contrast to FRET-based assays, this allows direct identification of interference of buffer constituents with the inhibitors, as demonstrated by the…
Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility - Bacterial or viral infections, such as Brucella, mumps virus, herpes simplex virus, and Zika virus, destroy immune homeostasis of the testes, leading to spermatogenesis disorder and infertility. Of note, recent research shows that SARS-CoV-2 can infect male gonads and destroy Sertoli and Leydig cells, leading to male reproductive dysfunction. Due to the many side effects associated with antibiotic therapy, finding alternative treatments for inflammatory injury remains critical. Here, we found…
Selective translational control of cellular and viral mRNAs by RPS3 mRNA binding - RPS3, a universal core component of the 40S ribosomal subunit, interacts with mRNA at the entry channel. Whether RPS3 mRNA-binding contributes to specific mRNA translation and ribosome specialization in mammalian cells is unknown. Here we mutated RPS3 mRNA-contacting residues R116, R146 and K148 and report their impact on cellular and viral translation. R116D weakened cap-proximal initiation and promoted leaky scanning, while R146D had the opposite effect. Additionally, R146D and K148D displayed…
Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors - Among the various genes and proteins encoded by all coronaviruses, one particularly “druggable” or relatively easy-to-drug target is the coronavirus Main Protease (3CLproor Mpro), an enzyme that is involved in cleaving a long peptide translated by the viral genome into its individual protein components that are then assembled into the virus to enable viral replication in the cell. Inhibiting Mpro with a small-molecule antiviral would effectively stop the ability of the virus to replicate,…
Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migration - CONCLUSIONS: Esculin inhibits β(2) integrin-dependent neutrophil migration and chemotaxis, blocks the cytoskeletal remodeling process required for neutrophil recruitment, thereby contributing to its protective effect against ALI. This study demonstrates the new therapeutic potential of esculin as a novel lead compound.
FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms - The continuing heavy toll of the COVID-19 pandemic necessitates development of therapeutic options. We adopted structure-based drug repurposing to screen FDA-approved drugs for inhibitory effects against main protease enzyme (Mpro) substrate-binding pocket of SARS-CoV-2 for non-covalent and covalent binding. Top candidates were screened against infectious SARS-CoV-2 in a cell-based viral replication assay. Promising candidates included atovaquone, mebendazole, ouabain, dronedarone, and…
4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses - Influenza outbreaks are associated with substantial morbidity, mortality and economic burden. Next generation antivirals are needed to treat seasonal infections and prepare against zoonotic spillover of avian influenza viruses with pandemic potential. Having previously identified oral efficacy of the nucleoside analog 4’-Fluorouridine (4’-FlU, EIDD-2749) against SARS-CoV-2 and respiratory syncytial virus (RSV), we explored activity of the compound against seasonal and highly pathogenic influenza…
Detection of pre-existing neutralizing antibodies against Ad26 in HIV-1-infected individuals not responding to the Ad26.COV2.S vaccine - CONCLUSION: Ad26.COV2.S vaccination showed a high failure rate in HIV-1-infected patients. Pre-existing immunity against Ad26 could be an important contributor to poor vaccine efficacy in a subgroup of patients.
Development of a novel angiotensin converting enzyme 2 stimulator with broad implications in SARS-CoV2 and type 1 diabetes - Angiotensin-converting enzyme 2 (ACE2) is protective in cardiovascular disease, lung injury and diabetes yet paradoxically underlies our susceptibility to SARs-CoV2 infection and the fatal heart and lung disease it can induce. Furthermore, diabetic patients have chronic, systemic inflammation and altered ACE2 expression resulting in increased risk of severe COVID-19 and the associated mortality. A drug that could increase ACE2 activity and inhibit cellular uptake of severe acute respiratory…
Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5’ untranslated region - One of the hallmarks of RNA viruses is highly structured untranslated regions (UTRs) in their genomes. These conserved RNA structures are often essential for viral replication, transcription, or translation. In this report, we discovered and optimized a new coumarin derivative C30 that binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome. To locate the binding site, we developed a novel sequencing-based method namely cgSHAPE-seq, in which the acylating chemical…
Human Surfactant Protein A Alleviates SARS-CoV-2 Infectivity in Human Lung Epithelial Cells - SARS coronavirus 2 (SARS-CoV-2) infects human angiotensin-converting enzyme 2 (hACE2)-expressing lung epithelial cells through its spike (S) protein. The S protein is highly glycosylated and could be a target for lectins. Surfactant protein A (SP-A) is a collagen-containing C-type lectin, expressed by mucosal epithelial cells and mediates its antiviral activities by binding to viral glycoproteins. This study examined the mechanistic role of human SP-A in SARS-CoV-2 infectivity. The interactions…
Role of C-Reactive Protein in Kidney Diseases - BACKGROUND: C-reactive protein (CRP) is an acute-phase protein and has been found to be a risk factor for acute kidney injury (AKI) and chronic kidney diseases (CKD). However, the role and mechanisms of CRP in AKI and CKD remain largely unclear.
The Stunning End of Dominion’s Case Against Fox News - The voting-machine company has agreed to a seven-hundred-million-dollar settlement in its defamation suit against Rupert Murdoch’s cable news network. - link
Biden’s New Green Jobs Are Boosting Purple and Red States - Why the President’s industrial policy could be key to his reëlection bid. - link
A Christian’s Thoughts on the Problem of Christian Nationalism - The separation of church and state, though under attack from the right, is still ingrained in our national psyche. Who’s best positioned to keep it there? - link
What Dominion Has to Prove in Its Case Against Fox News - Did the hosts of the country’s most popular cable news network know that Trump’s lies about the election were untrue? - link
What’s Behind the Bipartisan Attack on TikTok? - A hundred and fifty million Americans are on TikTok. Evan Osnos and Chris Stokel-Walker discuss why politicians are so keen to ban the app. Plus, Broadway’s new comedy of white wokeness. - link
+The director of the new Joaquin Phoenix film on animation, nightmares, and all those signs. +
++Asking Ari Aster to explain his movies is not a winning proposition, and thank goodness. The director of Hereditary and Midsommar works highly intuitively, and that shows up on the screen. While his films seem to beg for a close reading — take, for example, all the many bizarre and hilarious signs in the background of his latest film, Beau Is Afraid — ultimately, they tend to defy explanation. +
++That makes his films less locked to one way of thinking about them, less obviously “about” one thing in particular. Audiences get the chance to feel their way through his movies, just as Aster does when he makes them. You can take away your own ideas and discomforts and revelations from Beau Is Afraid, and they might not be the same as anyone else’s, and that’s just fine. +
+ ++Nevertheless, it’s fun to talk to Aster, who is deliberate and insightful about his own working process. Shortly before the film’s release, he and I spoke about how he designed some of the movie’s more comical and whimsical elements, what he’s trying to do when he makes a movie, and one little key to understanding Beau. +
++This interview has been edited and condensed for clarity. +
++Midsommar fans keep asking me about this movie. The way I describe it is that, whereas Midsommar is an inversion of a Disney Princess fantasy, this is an inverted, twisted hero’s odyssey. Did it start off being that kind of story? +
++It was always something of a risk, playing with the hero’s journey. But it’s also a film that’s about an unlived life. It’s set in this cartoon world that should function as a mirror of the world we’re in. It’s awful in all the ways that the world is awful, but with the dial turned just a little bit higher. +
++The trick was to make Beau very real. He’s our surrogate. He is who we have to hold on to. The challenge was, how do I make that experience incredibly visceral and immersive, and then at the same time, put him in this world that is just endlessly malign? +
+ ++That’s part of what’s so stressful and good about it. It honestly mirrored some of my most banal but aggravating recurring dreams, and that made it even more tense. I have a recurring nightmare where I need to go somewhere, and everyone I encounter is keeping me from getting there. I have nightmares about everything I do in life being projected in front of the whole world. The fantasy that everyone’s mad at me. These are all very common, boring things that everyone encounters, and yet they are the world as it exists to Beau. Right? +
++Yeah. It was very liberating to just have this invented world that allowed me to go wherever my intuition led me. If some very stupid idea made me laugh, the challenge was to find a way to get it in there and have it be cohesive with the whole. But there was nothing too crazy, too stupid, too strange. That was just fun. +
++It felt like one guy’s nightmare that just kept getting worse. +
++Hopefully, it’s not a pile-on. I tried to shape it so that there were these respites, where the nature of the film would keep changing. Again, it’s tricky, because you hope that all those pieces are in harmony with each other. But with a film like this, you’re really, really clinging to your intuition. +
++And nightmares are funny — when you’re not having them. +
++Yes, that’s right. +
+ ++The character of Beau is extremely passive, the kind of guy who, if you accuse him of doing something, he probably assumes he deserves it. He’s afraid of not following the rules. A revealing detail for me is that he’s trying to leave his apartment, but what he goes back for is … dental floss. +
++Well, I’ll say this. If you pay close attention, you’ll see that he almost takes the dental floss when he is packing his bag. He stopped. He hesitates, holding the floss, and then takes something else, and then goes back for the floss. I think there’s a key there. +
++The movie is so obviously about guilt that it’s not even worth saying that. It’s about a guy who’s really trapped in himself, really, really, really trapped. I’m somebody with a lot of ambivalence. Ambivalence is a very particular kind of hell. +
++I really, really want to avoid saying much because I really feel that if you can get on its wavelength, then it’s … it’s a movie that I felt my way through. I have a feeling that’s the only way to watch it as well. +
+ ++My favorite part of the movie might be the massive amount of signage throughout: the graffiti, the posters in the bedroom, there are signs everywhere. My favorite is that there’s a notice about a brown recluse in the building taped to everybody’s door in Beau’s apartment complex, and on the bottom of the sign is a quote from Winston Churchill: “The price of greatness is responsibility.” +
++Oh, you got that, great. There’s always a sadness in me thinking about all those details that will never be noticed. You’re the first person who caught that. That Churchill quote really makes me laugh. It’s the stupidest. +
++That was part of the fun of creating this world. I wanted to make sure that every billboard, every poster, every product, every newspaper was made from scratch, and was made in the spirit of the world: evil comedy. All the comic details. +
++There’s this term that was coined by Will Elder, from Mad magazine: chicken fat. It’s the overabundance of background gags that have been crammed into any given panel. I wanted there to be a lot of chicken fat here. I spent a long time building out a list of stupid names and names that made me laugh. +
++These are things that nobody will know that just made me laugh. Like the city that Beau lives in, in the first part of the film, is called Corrina, Corrina. The city is Corrina. The state is Corrina. That’s a reference to a Whoopi Goldberg and Ray Liotta film from the ’90s. +
++Ha! My friends and I were debating about where that actually was supposed to be. +
++He lives in Corrina, Corrina. And then he goes to Wasserton at the end, the home of Mona Wassermann. +
++That was a very joyful part of the process. Fiona Crombie was the production designer. She was a joy to work with. It was very fun making sure that the world was dense with detail. +
+ ++I couldn’t stop giggling at the poster in the teenage daughter’s bedroom that has the faces of all the K-pop stars, and the band is called “Ki55,” and the tagline is “We are 55 boys and we love you.” And both times I’ve seen it, the whole audience lost it when Beau walks up to his mother’s house and sees the caterer’s van with “Shiva Steve’s Grub For The Grieved” on the back of it. +
++There are also those signs nailed to trees as Beau is walking into the woods to meet the theater troupe. They have uplifting slogans about following your dreams and are from musicals, right? +
++Those are all lyrics from Broadway musicals and plays. I found that fun that it starts with “Know Thyself,” and then every sign gets dumber and dumber, so it’s all platitude lyrics. +
++It took me till the second viewing to realize that Beau’s defense lawyer at the end is standing beneath a sign that says 1-800-DEFENCE on it. +
++Well, yeah. They clearly just couldn’t get all the numbers they needed. +
++Let’s talk about the animated “Hero Beau” sequence. How did that come into being? +
++That’s a sequence in which Beau enters a play. He’s hypnotized, and he enters the play in his mind. We knew that there was going to be a lot of stagecraft involved; that was the original idea. Then I realized that I wanted it to be animated as well, or I wanted there to be animated elements that were interacting with the stagecraft. +
++I was really obsessed with this stop-motion monstrosity called La Casa Lobo by Cristobal Leon and Joaquin Cocina. These Chilean animators were so brilliant. I reached out to them to see if they would want to collaborate. I had already shotlisted and storyboarded the sequence, but it became very clear, pretty early on, that not only should they do all the animation, but because that would be interacting with the stagecraft, they should also be the ones to develop the look of the flats and the sets. We spent a long time in development on that, finding an aesthetic that did not clash with the rest of the film. +
++I think I drove them nuts, but it was a lot of fun. I’d love to work with them again. +
+ ++We also enlisted the help of an animation producer, a supervisor, to keep everything organized and on track, and make sure that that was always growing as we were making the rest of the film, because it needed constant attention. His name is Jorge Canada Escorihuela. He was really just essential to that getting made in that way and in the right way. He just understood so well what we were doing and kept that train on the tracks. I love him so much, and I know that Cristobal and Joaquin love him. He really, really was so committed to this. He gave it his whole life. It really was a huge undertaking, to be managing that while we were building out all the other worlds. Every shot of that sequence was a world that we not only had to animate later, but we had to build it and shoot it on a stage. So just getting all of that built was a lot. +
++When the animated sequence started, I scribbled down “dream ballet?” because it reminded me of those very Freudian dream ballets that pop up in the middle of musicals from the ’50s and ’60s. Sometimes they reveal the desires of the main character or retell the story in these mythic terms. Was that where this sequence came from? +
++Well, The Red Shoes certainly came to mind. I know that I sent the guys The Ballad of Narayama, because that is so drawn from kabuki techniques and the artifice is so extreme. What else? We were talking about Karel Zeman, especially Invention for Destruction. We were hoping also just to find a look that was its own. +
++Something great about this movie, I think, is that it runs against the tendency of contemporary moviegoers to demand that things be puzzles to be solved or mysteries that can be unlocked. +
++I agree. +
++With this, it’s about feelings. The pieces are not there to be fitted together into a puzzle. +
++No. If anything, the movie’s like an echo chamber. It’s sort of like a hall of mirrors. I want to encourage a deep engagement with it. I want you to search the movie because there’s a lot that I’ve buried as well, and a lot that I think I imagine will make itself much more clear upon a second viewing, just by knowing where it goes, to watch it again and see, “Oh, right. I guess this is a motif.” +
++I don’t know how obvious those things are or if I was able to bury them into the fabric so that it’s not just … there. I think the movie very much just is what it is. +
++Beau Is Afraid opens in limited theaters on April 13 and wide on April 20. +
+What happens if the Colorado River keeps drying up? +
++You may have heard this before: The Colorado River, which supplies drinking water to seven states in the US and two in Mexico, is the lifeblood of the American West and beyond. It’s drying up at an alarming rate, threatening cities, industries, agriculture, and energy sources. As it shrinks, rich ecosystems across its 1,450 miles are also disappearing. +
++In this issue of The Highlight, Vox’s reporters across the science, health, climate, and Future Perfect teams explore the interconnected causes of this crisis, the startling consequences that are already reshaping life in this important region of the world, and the difficult trade-offs we may need to accept to avert disaster. +
++One in eight Americans depend on a river that’s disappearing. +
++By Umair Irfan +
++A huge amount of US food is grown in the desert using water from a river that’s drying up. +
++By Benji Jones +
++The Colorado River is going dry … to feed cows. +
++By Kenny Torrella +
++How extreme weather is driving a deadly fungus further into the American West +
++By Keren Landman +
++Wildlife needs water, too. +
++By Benji Jones +
++CREDITS +
+
+Editors: Sam Oltman, Brian Resnick, Adam Clark Estes, Bryan Walsh
Copy editors/fact-checkers: Elizabeth Crane, Kim Eggleston, Tanya Pai, Caitlin PenzeyMoog
Additional fact-checking: Anouck Dussaud, Sophie Hurwitz
Art direction: Dion Lee
Audience: Gabriela Fernandez, Shira Tarlo, Agnes Mazur
Production/project editors: Lauren Katz, Nathan Hall
+
+The Colorado River is going dry … to feed cows. +
++
++Part of the issue The 100-year-old-mistake that’s reshaping the American West from The Highlight, Vox’s home for ambitious stories that explain our world. +
++Last May, 30 miles east of the Las Vegas Strip, a barrel containing a dead body washed up on the shores of Lake Mead, the country’s largest water reservoir. In the following months, more human remains surfaced, along with a World War II-era boat and dozens of other vessels. +
++While these discoveries might sound like the opening to a crime thriller, they’re more than just morbid curiosities — they’re flashing warning signs that the Colorado River, which supplies water and hydropower to 40 million Americans, is in crisis. +
++Along with Lake Powell 300 miles away, Lake Mead stores water for the lower states along the Colorado River: California, Arizona, and Nevada as well as Mexico and around 20 Indigenous reservations. But a climate change-induced “megadrought” has led to higher rates of water evaporation in recent decades and a drastic reduction in water supply, with Lake Mead currently at just 29 percent capacity. The streamflow on the northern part of the river, which supplies Colorado, New Mexico, Utah, Wyoming, and five Indigenous reservations, has fallen 20 percent over the last century. +
+ ++Heavy snowfall in the Rocky Mountains this winter should give Lake Powell a modest boost as it melts, but not enough to assuage fears over the lakes reaching what’s termed “dead pool” status, when water levels drop too low to flow through the dams. To avoid that fate, the federal government has urged states to cut their water use. +
++But despite news stories about drought-stricken Americans in the West taking shorter showers and ditching lawns to conserve their water supply, those efforts are unlikely to amount to much — residential water use accounts for just 13 percent of water drawn from the Colorado River. According to research published in Nature Sustainability, the vast majority of water is used by farmers to irrigate crops. +
+ ++And when you zoom in to look at exactly which crops receive the bulk of the Colorado River’s water, 70 percent goes to alfalfa, hay, corn silage, and other grasses that are used to fatten up cattle for beef and cows for dairy. Some of the other crops, like soy, corn grain, wheat, barley, and even cotton, may also be used for animal feed. +
+ ++“Meat production is the most environmentally stressful thing people do, and reducing it would make a huge impact on the planet,” said Ben Ruddell, a professor of informatics and computing at Northern Arizona University and co-author of the Nature Sustainability paper, over email to Vox. “We’ve known this for a long time.” +
++The stress on the West’s water supply due to alfalfa is especially acute in Utah: A staggering 68 percent of the state’s available water is used to grow alfalfa for livestock feed, even though it’s responsible for a tiny 0.2 percent of the state’s income. Last year, the editorial board of the state’s largest newspaper, the Salt Lake Tribune, declared that “it’s time for Utah to buy out alfalfa farmers and let the water flow.” +
++California takes more water from the Colorado River than any other state, and most of it goes to the Imperial Valley in the southern part of the state. It’s one of the most productive agricultural regions in the US, producing two-thirds of America’s vegetables during winter months. But the majority of the Imperial Valley’s farmland is dedicated to alfalfa and various grasses for livestock. +
++In Arizona, Phoenix’s backup water supply is being drained to grow alfalfa by Fondomonte, owned by Saudi Arabia’s largest dairy company, which it ships 8,000 miles back to the Middle East to feed its domestic herds. (Water-starved Saudi Arabia banned growing alfalfa and some other animal feed crops within its own borders in 2018.) Across the 17 Western states, at least 10 percent of alfalfa is shipped to Asia and the Middle East where meat and dairy consumption is low compared to the US but on the rise. +
+ ++A drought is the product of two interlocking factors: supply and demand. We can point to climate change for the drought that’s drying up the water supply that is the Colorado River, but we have to reckon with the fact that the West’s already limited water is primarily used to grow a low-value crop, alfalfa, while cities are left to spend heavily on water-saving infrastructure to keep the H2O running and ensure reserves. And ironically, all that alfalfa is used to produce beef and dairy — two food groups that themselves contribute significantly to climate change. In other words, we’re using water supplies that have been shrunk in part by climate change to produce food that will in turn worsen climate change. +
++The West’s water squeeze can be explained by poor planning in its past, but it raises a difficult question for its future: As local and state governments are forced to adapt their water use to a changing climate, do we also need to start thinking about adapting our diets? +
++When I asked John Matthews, executive director of the Alliance for Global Water Adaptation, why there are so many water-intensive farming operations in the desert ecosystem of the Southwestern US, he had a simple answer: If we could start from scratch, we would not have designed the system we have today. +
++“I don’t think a farmer would design it this way,” he said. +
++The West’s water system has its roots in the 1862 federal Homestead Act, which gave Western settlers up to 160 acres of land for free if they agreed to improve it and stay on it for at least five years, and later offered even more land at a reduced price if they agreed to farm it. But because there was so little water and irrigation was shoddy, Congress passed the Reclamation Act in 1902 to “reclaim” arid land in the West for agriculture. The federal government sold tracts of land to fund massive irrigation damming projects to divert rivers and streams to farms. Armed with cheap land and water backed by federal price guarantees — and aided by a warm climate that permitted an expanded growing season — Western settlers began to farm cotton and alfalfa. +
+ ++Choosing to put farms on arid land wasn’t the only short-sighted mistake the region made. In 1922, negotiators representing the seven states that share the river’s water grossly overestimated just how much water it could provide, which locked in over-apportionment and thus overuse. +
++Of course, government officials at the time also couldn’t foresee a historic, climate change-fueled drought, or the growth of sprawling metropolises like Phoenix and Las Vegas in the decades to come that would compete with agriculture for limited resources. (In 1920, Arizona’s total population was just 334,000 people — around 20 percent of Phoenix’s current population — while all of Nevada had only 77,000 people.) +
++And most importantly — and at the heart of the conflict today between California and its fellow Colorado River users — is how water rights were obtained. +
++In the Eastern US, water rights are determined using what’s called the riparian doctrine — everyone who lives near a body of water has an equal right to use it, and is entitled to a “reasonable use” of it. The Western US, as is the case in so many other areas, does things differently. +
++Water rights in the West were determined — under state laws — by what’s called the prior appropriation doctrine, which gives senior water rights to whoever first uses the water, a right they retain so long as they continue to use it. And those rights were mostly snatched up by miners during the Gold Rush era of the mid-1800s and farmers in the following decades who came to the West after the Homestead and Reclamation Acts (and some of that water and land was taken from Indigenous tribes). Even in times of shortage, senior water rights holders — many of them farmers — get priority over latecomers, like those millions of Western urbanites. +
++That created repeated conflict — as the old Western saying goes, “Whiskey is for drinking, water is for fighting.” Over 150 years after the Gold Rush, fights over the prior appropriation doctrine are as fierce as ever, playing out in communities and between states, like Cochise County, Arizona, residents battling a water-guzzling mega-dairy, or the six Colorado River states that have agreed to slash their use to make up for the shortfall while California refuses to commit to necessary reductions. It’s now the Golden State versus everyone else. +
++California public officials, like many California farmers, argue that they don’t need to cut their water use so drastically because they hold senior rights. That’s now up in the air. Earlier this month, the Department of the Interior published a draft analysis detailing three options it can take if states fail to reach an agreement: do nothing, make cuts based on existing water rights, or cut water allotments evenly among California, Arizona, and Nevada. +
++“This is what we have inherited: a very rigid and complex system,” said Nick Hagerty, an assistant professor of agricultural economics at Montana State University, back in February. +
++Matthews was blunter: “It is a stupid system, but the problem is that people are really heavily invested in that system.” +
++However, it’s hard to get those who’ve benefited from the system for so long to change. California’s Imperial Valley, home to many alfalfa farms, gets about as much water from the Colorado River as the entire state of Arizona — and farmers in the Valley pay just $20 per acre foot (326,000 gallons). Meanwhile, farmers and residents in nearby San Diego County pay around $1,000 or more per acre-foot. +
++Many Imperial Valley farmers are reluctant to reduce their use, citing their senior water rights. One farmer who chairs an agricultural water committee for the valley’s water district told Cal Matters that unless the federal government adequately compensates farmers, mandated cuts could be akin to property theft, and blamed water shortages on urban growth and excessive use from junior water rights holders. +
++The Imperial Irrigation District now conserves around 15 percent of its allocation, though much of that conservation is funded by San Diego County, which receives some water from the district. +
++Sudden changes to the water supply can hit farmers hard, and assistance has taken various forms in recent years — and experts like Matthews want to see them get the help they need to adapt to a different, drier economy. As the US Bureau of Reclamation has reduced the water supply for several states and Mexico, a patchwork of federal and state initiatives have moved forward to compensate farmers to reduce water use. +
+ ++Late last year, the Biden administration announced it will use some of the $4 billion in drought mitigation from the Inflation Reduction Act to pay farmers — as well as cities and Indigenous tribes — to cut their water use. Utah lawmakers recently proposed spending $200 million on grants for farmers to invest in promising but costly water-saving technologies, while farmers in Southern California have been paid to skip planting some of their fields. +
++But Hagerty says a lot more could be done: “I think it’s incredibly important there be more flexibility in the system.” He wants to see farmers have more leeway to transfer, sell, or lease their water rights to cities. In California, farmers don’t directly hold their water rights and instead are members of irrigation districts that collectively hold those rights. But California law often impedes the districts from leasing water, leading some farmers to use water even if it may not be critical to their operations because if they don’t use it, they lose it. +
++One solution he’s proposed is a reverse auction, in which water users make bids to the federal government on how much money they’d accept to forgo a particular amount of water use. But he says any reform will inevitably be incremental because there are so many competing interests at play. +
++“Policymakers have been hesitant to make any real major changes, and I think that’s partly because this stuff is very politically fraught,” Hagerty said. “There’s a whole lot of different stakeholders to keep happy.” +
++A number of short-term solutions should be enough to help Colorado River states get through the next few years, but in the long term, policymakers and food producers — and us — around the world will need to rethink how we farm and eat in a changing climate. It won’t be enough to simply change farming practices in the Western US, as Ruddell, a co-author of the Nature Sustainability paper, noted to me. +
++That means altering the demand side of the water supply-demand equation and shifting diets globally to foods that use less H2O, which ultimately means less meat and dairy, as well as fewer water-intensive tree nuts like almonds, pistachios, and cashews (nut milks, however, require much less water to produce than cow’s milk). +
++Agriculture isn’t just the largest user of water in the Southwestern US, it’s the largest globally, consuming 70 percent of freshwater withdrawals. And what we need in the Southwest and beyond isn’t just climate adaptation, but dietary adaptation. +
+ ++Just as policymakers made the Western US into the agricultural powerhouse it is today, despite its lack of something that is generally considered key to farming — water — they can also shape water policy and broader agricultural policy to ensure water security for the tens of millions of Americans west of the Mississippi River. But that will require policy changes that go beyond the dinner table. +
++The federal government, through deregulation, R&D investments, subsidies, and food purchasing (like for public schools and federal cafeterias), heavily favors animal agriculture. Given the meat and dairy lobby’s political influence and farm states’ overrepresentation in the Senate, drastic changes to our food supply in the near term, ones that would favor plant-based agriculture, are out of the realm of political possibility. But change is afoot: In March, the Biden administration announced goals to bolster R&D for plant-based meat and dairy and other animal-free food technologies. Down the road, climate change may force some state and federal government’s hands to turn those goals into comprehensive agriculture policy. Already, American policymakers are mulling and making hard choices about water use, pitting crops for cows against water for people. +
++There’s no disagreement that if the Colorado River can continue to supply Americans with running water, there will need to be cuts to agricultural use. We can learn from the mistakes made by Western planners in 1922 who overestimated how much water would flow from the Colorado River, and act now to shape food policy to adapt to a warming, drier climate. +
++Special thanks to Laura Bult and Joss Fong on the Vox video team, whose extensive research for a November 2022 video on this subject contributed to this story. +
Defence Minister Rajnath Singh’s son Pankaj to become Cycling Federation of India president - Pankaj Singh emerged as the lone candidate for the post of the president of the Cycling Federation of India (CFI); all the 25 members of the CFI executive council will be elected unopposed
During Ramzan, street cricket lights up Karachi after midnight -
Suryakumar Yadav continues to lead ICC T20 rankings - Suryakumar, who has endured a lean run of late, remained static on the ICC list with 906 rating points, and is over a 100 points ahead of the second placed Mohammad Rizwan (798) of Pakistan
Champions League | Rodrygo double eases Real Madrid past Chelsea into semifinals - Rodrygo netted twice from close range for Real Madrid as Chelsea suffer fourth straight defeat under Frank Lampard; AC Milan defeat Napoli 2-1 on aggregate
Asian Champions Trophy is a litmus test for Asian Games: Harmanpreet Singh - In the previous edition in 2021 held in Dhaka, the Indian team finished with a bronze medal
Ambasamudram custodial torture | FIR details horrendous torture suffered by three youth at the hands of suspended IPS officer Balveer Singh - The three were summoned to the Manimuthar police canteen around 1 p.m. on March 25 and allegedly given Rs. 30,000 each by advocate Thirumalaikumar, Ms. Rajakumari and Mr. Abraham Joseph, which was videographed by special branch constable Rajkumar.
Defence Minister Rajnath Singh’s son Pankaj to become Cycling Federation of India president - Pankaj Singh emerged as the lone candidate for the post of the president of the Cycling Federation of India (CFI); all the 25 members of the CFI executive council will be elected unopposed
MLA’s convoy attacked by suspected Maoists in Chhattisgarh; no one injured - A car carrying a Zila Parishad member was fired upon
Income Tax officials search properties of Congress leader KGF Babu - The IT sleuths seized around 5,000 sarees meant for distribution among voters besides a large number of demand drafts
Construction of ABC centre nearing completion - The centre, constructed under the aegis of Alappuzha district panchayat, is expected to give a major boost to the animal birth control programme aimed at curbing the stray dog menace.
Ukraine war: The Russian ships accused of North Sea sabotage - Disguised Russian ships are said to be preparing sabotage plans in case of war with Western powers.
Macron tries to escape French pension row with street song - The French leader tries to relaunch his presidency as a video is shared by a group linked to the far right.
Russia-linked hackers a threat to UK infrastructure, warns minister - Officials are urging organisations to “act now” to defend themselves against the cyber threat.
Ukraine’s Eurovision 2023 act TVORCHI have war on their mind - Nigerian-Ukrainian duo TVORCHI met in a chance encounter on the street. Now they’re coming to the UK.
What Americans can learn from Denmark on handling debt ceiling crisis - Only two industrialised nations have debt ceilings - how come only the US fights about it?
Can an e-bike’s fat tires be offset by a fat battery? - A well-implemented electric boost handles some of the worst of ultra-fat tires. - link
Building telescopes on the Moon is becoming an achievable goal - The current race to the Moon is opening up opportunities for lunar astronomy. - link
Dealmaster: New low on 55-inch LG C2 TV and 2021 iPad Pro, and more - These are the lowest prices we’ve seen on LG’s 55-inch C2 and Apple’s 2021 iPad Pro - link
Star Trek fans will finally get a Section 31 movie—with an Oscar-winning lead - Yeoh will reprise her role as Emperor Philippa Georgiou for a streaming movie. - link
Hundreds of years after the first try, we can finally read a Ptolemy text - The original writing was hidden in part by a 19th century attempt to read it. - link
What do you call a deaf gynecologist? -
++A lip reader. +
+ submitted by /u/JimmysMomGotItGoinOn
[link] [comments]
Boys have a thing and girls don’t. -
++One November afternoon when my daughter was in kindergarten, I picked her up after school. She bobbed out to the car and crawled into the back seat. +
++“What did you do today?” I asked. +
++She couldn’t wait to tell me. “We learned that boys are different from girls” she chirped. +
++Looking into the rearview mirror, I could just see the top of her head. “My teacher told us that boys have a thing and girls don’t,” she added. +
++“Well, yes they do…” I said cautiously. +
++I couldn’t think of anything else to say, so we were quiet for a moment. Then she piped up again. “That’s how girls know that boys are boys,” she said. “They see that thing that hangs down and they know that he is a boy.” +
++I mentally calculated the distance home. Our five-minute commute already felt like an hour. +
++“Did you know that when the boys see a girl they puff up?” +
++My palms were beginning to sweat. +
++“Um…well…” I was still searching for something new to say, to change the subject when she asked, “Why do the girls like the boys to have those things?” +
++Well, I didn’t know what to say. I mean, what woman hasn’t asked herself that question at least once? “Oh, well…um…” I stammered. +
++She didn’t wait for my answer. She had her own. “It’s ‘cause it moves when they walk and then the girls see that and that’s when they know they are boys and that’s when they like them. Then the boy sees the girl and he puffs up, and then the girl knows he likes her, too. And then they get married. And then they get cooked.” +
++That last part confused me a bit, but on the whole, I thought she had a pretty good grasp on things. +
++As soon as we got home and I pulled into the garage, she hopped out of the car, fishing something out of her school bag. +
++“I drew a picture,” she said. “Do you want to see?” +
++I wasn’t sure I did, but I looked at it anyway. I had to sit down. +
++There, all puffed up so to speak, looking mighty attractive for the ladies, was a crayon drawing of a great big Tom Turkey. His snood, the thing that hangs down over his beak, the thing that female turkeys find so irresistible, was magnificent. His tail feathers were standing tall and proud. +
++She was a little offended that I laughed so hard at her drawing, and I laughed until I cried. But when I told her I loved it … and I did … she got over her pique. +
++That was the end of that, for her anyway. But I’m not so lucky. Every year I remember that conversation. And to be honest, I haven’t looked at a turkey, or a man, the same way since. +
+ submitted by /u/Waitsfornoone
[link] [comments]
A boy is born with just a head. -
++A boy is born with just a head. No neck, body, arms or legs. His parents love him, and vow to give him a life like any other child. +
++The boy lives a fulfilling and miraculous life, and after a while, he turns 18, and his father takes him to a bar for his first pint of beer. +
++The boy takes his first sip, and after finishing the beer, suddenly his neck pops out. +
++“By God!”, his father exclaims. “You’ve grown a neck!” His father urges him to drink another beer, to see if anything else might happen. Without hesitating, the boy drinks another beer. Suddenly, a torso pops out. The entire population of the bar are cheering him on. +
++His father and everybody else are urging him to drink more, and with each finished drink pops another body part. First, a pair of arms, then a pair of legs. This continues until his entire body is fully grown. +
++“Father, I can’t believe it! I can finally walk. I can use my hands, and my legs. I can even run! Watch!” +
++Without further ado, the boy runs out of the bar, shouting joyfully. +
++Suddenly, the boy runs into a busy road, and is unfortunately ran over by a truck. +
++The boy died instantly. +
++Everybody in the bar is silent - besides the bartender, who says to the boys father; +
++“What a shame. He should have quit whilst he was a head.” +
+ submitted by /u/PretzelsEqualThursty
[link] [comments]
Wife: I’m afraid our Neighbour died -
++Husband: Who, Ray? +
++Wife: It’s inappropriate to cheer when someone dies +
++(My 7 year old came up with this joke) +
+ submitted by /u/Suspicious_Airline89
[link] [comments]
What did Neil Armstrong say when no one laughed at his moon jokes? -
++“I guess you had to be there.” +
+ submitted by /u/Cubelock
[link] [comments]