diff --git a/archive-covid-19/24 February, 2024.html b/archive-covid-19/24 February, 2024.html new file mode 100644 index 0000000..7034865 --- /dev/null +++ b/archive-covid-19/24 February, 2024.html @@ -0,0 +1,169 @@ + +
+ + + +GS-441524 for COVID-19 SAD, FE, and MAD Study in Healthy Subjects - Conditions: COVID-19
Interventions: Drug: GS-441524; Drug: Placebo
Sponsors: National Center for Advancing Translational Sciences (NCATS); Leidos Biomedical Research, Inc.; ICON Government and Public Health Solutions, Inc
Not yet recruiting
UNAIR Inactivated COVID-19 Vaccine INAVAC as Heterologue Booster (Immunobridging Study) in Adolescent Subjects - Conditions: COVID-19 Pandemic; COVID-19 Vaccines
Interventions: Biological: INAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 Ī¼g
Sponsors: Dr.Ā Soetomo General Hospital; Indonesia-MoH; Universitas Airlangga; PT Biotis Pharmaceuticals, Indonesia
Active, not recruiting
The Aerobic Exercise Capacity and Muscle Strenght in Individuals With COVID-19 - Conditions: COVID-19 Pneumonia; COVID-19
Interventions: Device: Kardiopulmonary exercise test (Quark KPET C12x/T12x device connected to the Omnia version 1.6.8 COSMED system); Device: Peripheral muscle strength measurement (microFET3 (Hoggan Health Industries, Fabrication Enterprises, lnc) and JAMAR hydraulic hand dynamometer (Sammons Preston, Rolyon, Bolingbrook).; Device: Standard exercise tolerance test (a bicycle ergometer and recorded through the ergoline rehabilitation system 2 Version 1.08 SPI.); Device: Aerobic exercise training (a bicycle ergometer and recorded through the ergoline rehabilitation system 2 Version 1.08 SPI.)
Sponsors: Selda Sarıkaya; Zonguldak Bulent Ecevit University
Completed
World Health Organization (WHO) , COVID19 Case Series of Post Covid 19 Rhino Orbito Cerebral Mucormycosis in Egypt - Conditions: Mucormycosis; Rhinocerebral (Etiology); COVID-19
Interventions: Procedure: debridment
Sponsors: Nasser Institute For Research and Treatment
Completed
Treatment of Post-COVID-19 With Hyperbaric Oxygen Therapy: a Randomized, Controlled Trial - Conditions: Post-COVID-19 Syndrome; Post-COVID Syndrome; Post COVID-19 Condition; Post-COVID Condition; Post COVID-19 Condition, Unspecified; Long COVID; Long Covid19
Interventions: Drug: Hyperbaric oxygen
Sponsors: Erasmus Medical Center; Da Vinci Clinic; HGC Rijswijk
Not yet recruiting
Mindfulness-based Mobile Applications Program - Conditions: COVID-19; Cell Phone Use; Nurse; Mental Health
Interventions: Device: mindfulness-based mobile applications program
Sponsors: Yu-Chien Huang
Completed
Attention Training for COVID-19 Related Distress - Conditions: Anxiety
Interventions: Behavioral: Attention Bias Modification; Behavioral: Attention Control Training; Behavioral: Neutral training
Sponsors: Palo Alto University
Not yet recruiting
Correlation of Antibody Response to COVID-19 Vaccination in Pregnant Woman and Transplacental Passage Into Cord Blood. - Conditions: Covid-19
Interventions: Diagnostic Test: COVID-19 Spike Protein IgG Quantitative Antibody (CMIA)
Sponsors: Vachira Phuket Hospital
Recruiting
UNAIR Inactivated COVID-19 Vaccine as Homologue Booster (Immunobridging Study) - Conditions: COVID-19 Pandemic; COVID-19 Vaccines; COVID-19 Virus Disease
Interventions: Biological: INAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 Ī¼g
Sponsors: Dr.Ā Soetomo General Hospital; Universitas Airlangga; Biotis Pharmaceuticals, Indonesia; Indonesia-MoH
Recruiting
Safety and Immunogenicity of a Sub-unit Protein CD40.RBDv Bivalent COVID-19 Vaccine, Adjuvanted or Not, as a Booster in Volunteers. - Conditions: COVID-19
Interventions: Drug: CD40.RBDv vaccin (SARS-Cov2 Vaccin)
Sponsors: ANRS, Emerging Infectious Diseases; LinKinVax; Vaccine Research Institute (VRI), France
Not yet recruiting
High-definition Transcranial Direct Current Ctimulation and Chlorella Pyrenoidosa to Reduce Cardiovascular Risk - Conditions: Cardiovascular Diseases; Long Covid19
Interventions: Other: High Definition-transcranial Direct Current Stimulation; Dietary Supplement: Chlorella Pyrenoidosa
Sponsors: Federal University of ParaĆba; City University of New York
Recruiting
SGB for COVID-induced Parosmia - Conditions: COVID-19-Induced Parosmia
Interventions: Drug: Stellate Ganglion Block; Drug: Placebo Sham Injection
Sponsors: Washington University School of Medicine
Recruiting
Antiviral Protein-Protein Interaction Inhibitors - Continually repeating outbreaks of pathogenic viruses necessitate the construction of effective antiviral strategies. Therefore, the development of new specific antiviral drugs in a well-established and efficient manner is crucial. Taking into account the strong ability of viruses to change, therapies with diversified molecular targets must be sought. In addition to the widely explored viral enzyme inhibitor approach, inhibition of protein-protein interactions is a very valuable strategy. Inā¦
Structural insights into IL-6 signaling inhibition by therapeutic antibodies - Antibody inhibitors of the interleukin-6 (IL-6) signaling pathway, such as tocilizumab and sarilumab, have been used to treat rheumatoid arthritis, chimeric antigen receptor T cell-induced cytokine storm, and severe COVID-19 pneumonia. Here, we solve the cryogenic electron microscopy structures of sarilumab and tocilizumab in complex with IL-6R to resolutions of 3.2 and 3.3 Ć , respectively. These structures reveal that both tocilizumab and sarilumab bind to the D3 domain of IL-6R. The bindingā¦
Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers - CONCLUSION: This trial with three microdosed FXaI suggests that at most the rivaroxaban dose should be reduced during short-term ritonavir, and only in patients receiving high maintenance doses. Thorough time series analyses demonstrated differential effects on three different drug-metabolising enzymes over time with immediate profound inhibition of CYP3A4 and only slow recovery after discontinuation.
Naphthoquinone derivatives as potential immunomodulators: prospective for COVID-19 treatment - Inflammation plays a crucial role in COVID-19, and when it becomes dysregulated, it can lead to severe outcomes, including death. Naphthoquinones, a class of cyclic organic compounds widely distributed in nature, have attracted significant interest due to their potential biological benefits. One such naphthoquinone is 3,5,8-trihydroxy-6-methoxy-2-(5-oxohexa-1,3-dienyl)-naphthanthene-1,4-dione (3,5,8-TMON), a compound produced by fungi. Despite its structural similarity to shikonin, limitedā¦
Cholesterol and COVID-19-therapeutic opportunities at the host/virus interface during cell entry - The rapid development of vaccines to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has been critical to reduce the severity of COVID-19. However, the continuous emergence of new SARS-CoV-2 subtypes highlights the need to develop additional approaches that oppose viral infections. Targeting host factors that support virus entry, replication, and propagation provide opportunities to lower SARS-CoV-2 infection rates and improve COVID-19 outcome. This includesā¦
Discovery of an ellipticine derivative as TLR3 inhibitor against influenza A virus and SARS-CoV-2 - Influenza and COVID-19 continue to pose global threats to public health. Classic antiviral drugs have certain limitations, coupled with frequent viral mutations leading to many drugs being ineffective, the development of new antiviral drugs is urgent. Meanwhile, the invasion of influenza virus can cause an immune response, and an excessive immune response can generate a large number of inflammatory storms, leading to tissue damage. Toll-like receptor 3 (TLR3) recognizes virus dsRNA to ignite theā¦
Investigating the Antibody Imprinting Hypothesis among Canadian Paramedics after SARS-CoV-2 Omicron Variant Circulation - Recent research has highlighted the Omicron variantās capacity to evade immune protection conferred by wild-type (WT) mRNA vaccines. Despite this observation, the potential involvement of antigenic sin phenomena remains unclear. Our hypothesis posited that a greater number of prior WT vaccine doses might lead to reduced anti-Omicron neutralization Abs following Omicron infection. To investigate this, we analyzed blood samples from human participants in the COVID-19 Occupational Risk,ā¦
The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections - Non-structural protein 1 (Nsp1) is one of the first proteins produced during coronaviral infections. It plays a pivotal role in hijacking and rendering the host gene expression under the service of the virus. With a focus on SARS-CoV-2, this review presents how Nsp1 selectively inhibits host protein synthesis and induces mRNA degradation of host but not viral mRNAs and blocks nuclear mRNA export. The clinical implications of this protein are highlighted by showcasing the pathogenic role of Nsp1ā¦
A case report of QTc prolongation: Drug induced or myocarditis in Severe Acute Respiratory Syndrome Coronavirus 2 - Remdesivir is a nucleotide prodrug of an adenosine analog. It binds to the viral Ribonucleic Acid (RNA)-dependent RNA polymerase and inhibits viral replication by terminating RNA transcription prematurely. Remdesivir has demonstrated in vitro and in vivo activity against Severe Acute Respiratory Syndrome Coronavirus 2; it also acts in vitro neutralization activity against the Omicron variant and its subvariants. We reported a 54-years-old woman admitted with Coronavirus disease 2019. Consideringā¦
Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimerās, and diabetes - The COVID-19 pandemic caused by the SARS-CoV-2 virus has greatly affected global health. Emerging evidence suggests a complex interplay between Alzheimerās disease (AD), diabetes (DM), and COVID-19. Given COVID-19ās involvement in the increased risk of other diseases, there is an urgent need to identify novel targets and drugs to combat these interconnected health challenges. Lysophosphatidic acid receptors (LPARs), belonging to the G protein-coupled receptor family, have been implicated inā¦
Synergistic inhibition effects of andrographolide and baicalin on coronavirus mechanisms by downregulation of ACE2 protein level - The SARS-CoV-2 virus, belonging to the Coronavirus genus, which poses a threat to human health worldwide. Current therapies focus on inhibiting viral replication or using anti-inflammatory/immunomodulatory compounds to enhance host immunity. This makes the active ingredients of traditional Chinese medicine compounds ideal therapies due to their proven safety and minimal toxicity. Previous research suggests that andrographolide and baicalin inhibit coronaviruses; however, their synergisticā¦
Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage - Viruses critically rely on various proteases to ensure host cell entry and replication. In response to viral infection, the host will induce acute tissue inflammation pulled by granulocytes. Upon hyperactivation, neutrophil granulocytes may cause undue tissue damage through proteolytic degradation of the extracellular matrix. Here, we assess the potential of protease inhibitors (PI) derived from potatoes in inhibiting viral infection and reducing tissue damage. The original full spectrum ofā¦
Individual ingredients of NP-101 (Thymoquinone formula) inhibit SARS-CoV-2 pseudovirus infection - Thymoquinone TQ, an active ingredient of Nigella Sativa, has been shown to inhibit COVID-19 symptoms in clinical trials. Thymoquinone Formulation (TQF or NP-101) is developed as a novel enteric-coated medication derivative from Nigella Sativa. TQF consists of TQ with a favorable concentration and fatty acids, including palmitic, oleic, and linoleic acids. In this study, we aimed to investigate the roles of individual ingredients of TQF on infection of SARS-CoV-2 variants in-vitro, by utilizingā¦
Design, synthesis and biological evaluation of novel 1,2,4a,5-tetrahydro-4H-benzo[b][1,4]oxazino[4,3-d][1,4]oxazine-based AAK1 inhibitors with anti-viral property against SARS-CoV-2 - Coronavirus entry into host cells hinges on the interaction between the spike glycoprotein of the virus and the cell-surface receptor angiotensin-converting enzyme 2 (ACE2), initiating the subsequent clathrin-mediated endocytosis (CME) pathway. AP-2-associated protein kinase 1 (AAK1) holds a pivotal role in this pathway, regulating CME by modulating the phosphorylation of the Ī¼ subunit of adaptor protein 2 (AP2M1). Herein, we report a series of novel AAK1 inhibitors based on previously reportedā¦
Role of epinephrine in attenuating cytokine storm, decreasing ferritin, and inhibiting ferroptosis in SARS-CoV-2 - CONCLUSION: Epinephrine may attenuate CS and inhibit ferroptosis which is an iron-dependent, non-apoptotic mode of cell death. Epi interacts with ferric and/or ferrous iron and built a stable complex that impedes activation of beta-adrenergic receptors. Epi may cause marked decrease of ferritin and other inflammatory markers. Epi may be used to decrease iron overload which is associated with many medical diseases like type 2 diabetes mellitus and cardiometabolic diseases such as coronary heartā¦
The Humanitarian Catastrophe in Gaza Can Only Get Worse - Trying to project the death toll from Israelās military campaign over the next six months. - link
Legal Weed in New York Was Going to Be a Revolution. What Happened? - Lawsuits. Unlicensed dispensaries. Corporations pushing to get in. The messy rollout of a law that has tried to deliver social justice with marijuana. - link
The Snake with the Emoji-Patterned Skin - In the wild, ball pythons are usually brown and tan. In America, breeding them to produce eye-catching offspring has become a lucrative, frenetic, andāfor someātroubling enterprise. - link
Matt Gaetzās Chaos Agenda - The Florida Republican is among the most brazen and controversial figures in Donald Trumpās G.O.P. Heās also among the most influential. - link
The Trials of Alejandro Mayorkas - The Secretary of Homeland Security has been forced to respond to an unprecedented flow of migrants to the U.S.-Mexico border. Why are Republicans in Congress impeaching him for it? - link
+Trumpās seemingly inevitable romp to victory in Nikki Haleyās home state reveals how strong his hold on the GOP is ā and how dangerous he remains to democracy. +
++Tonight, South Carolina will hold its Republican presidential primary, in which Donald Trump is all but certain to crush rival Nikki Haley in her home state. Ordinarily, this might feel like big news, as the Palmetto State tends to host one of the most important early contests. Joe Bidenās 2020 victory in the state, after dismal finishes in Iowa and New Hampshire, is one of the biggest reasons heās president today. +
++But the coming vote feels irrelevant: The 2024 Republican primary isnāt and never has been a competitive primary. Trump simply wasnāt going to lose a contest for the hearts and minds of the Republican base. Ideologically, psychologically, even spiritually ā itās the Trump party through and through. +
++I and others have been arguing this for years now. Yet during those same years, many prominent people in politics and the media deluded themselves into thinking he might be dethroned. They have been wrong every time and continued to be wrong long after the strength of Trumpās grip on the GOP could not be denied. +
++Thereās a lesson to be learned from this track record of failure, one deeper than just āRepublicans really like Donald Trump.ā Trumpās persistence tells us something critical about the nature of the current Republican party ā and why itās become such a danger to American democracy. +
++Ever since the early stages of the 2016 GOP primary, the same pattern has repeated itself over and over again: Some new development that looked politically dangerous for Trump ends up not mattering at all. This happened so many times in the 2016 election cycle alone that it became a running joke during the campaign. +
+ ++The pattern continued through Trumpās presidency, and most strikingly after January 6 ā when Trump managed to maintain majority support in the Republican party after inciting an honest-to-god insurrection. At that point, youād think it would be obvious that Trump was going to cruise to renomination in 2024. Yet somehow, the delusions of a Trump collapse persisted. +
++During the January 6 Committee meetings in summer 2022, there was widespread speculation that the dramatic public hearings had weakened Trumpās hold on the GOP. Republican primary voters proceeded to disprove this theory by booting the House members who voted for his impeachment and nominating full-MAGA election deniers, like Arizonaās Kari Lake, to contest key swing races around the country. +
++These candidates performed poorly in the 2022 midterms, while Florida Gov.Ā Ron DeSantis cruised to reelection. This led many observers to see DeSantis as a possible Trump killer, with some going so far as to anoint DeSantis the frontrunner in early 2023. Soon after that, DeSantisās poll numbers collapsed. +
++After the DeSantis train crashed, Trump skeptics crowned Haley the next anti-Trump Republican hope. She secured critical funding from Americans for Prosperity Action, the political arm of the Koch empire, in November ā raising the Haley hype to surprising heights going into 2024. In mid-January, prominent pundit Jonathan Rauch gave Haley roughly a 40 percent chance to win the primary, adding that āthe odds might shift in her favor quickly.ā +
++Then she lost by double-digits in her supposed stronghold of New Hampshire, and the writing was on the wall in great big bold letters. +
++None of this speculation tracked Trumpās poll numbers. The former president consistently led in the polling averages, generally by wide margins. So why did so many get this so wrong? +
++Sometimes, the explanation is mundane wishcasting: centrist or anti-Trump Republicans desperately wishing to avoid a choice between a threat to democracy and a Democrat. But in some cases, thereās a more interesting explanation ā that even some of the GOPās critics didnāt fully appreciate what it had become. +
++New York magazineās Jonathan Chait, one of the more perceptive of these critics, was an early booster of DeSantisās chances. In August of last year, he admitted that he had gotten it wrong ā and wrote an interesting column trying to explain why he erred. Chaitās basic argument is that Trumpās cult of personality was far more powerful than he had appreciated. +
++āDefeating Trump in a contest determining who can most effectively advance ideological or party goals is difficult but attainable. It is obviously impossible to defeat Trump in a contest of who is most loyal to Trump,ā Chait concluded. +
++This is surely a key part of the story. But it also raises a more fundamental question that Chait doesnāt attempt to answer: Why does the Republican base have such unwavering faith in the man? +
++Trumpās celebrity charisma alone isnāt enough of an explanation. Otherwise, former California Gov.Ā Arnold Schwarzenegger would bestride the GOP like a colossus. Nor is Trumpās fawning coverage in the conservative media. Fox News has repeatedly tried to turn the Republican base away from Trump and toward figures like DeSantis, only to have to kiss the ring when the voters didnāt follow their lead. +
++The answer, at least as far as I can tell, is that Trumpās cult is the product of his unique ability to channel the cultural grievances at the heart of the current Republican party. +
++Again and again, social scientists found that the best predictor of Trump support among Republican voters is the degree to which they feel discomfort with the changing nature of American demographics and social norms. Trump has sold himself as the only person capable of fighting back against the alleged elite conspiracy behind these changes, saying things like āI alone can fix itā and āI am your retribution.ā From these building blocks, he has created a full-scale political movement dedicated to reconquering America. +
+ ++Trumpās appeal isnāt premised on delivering concrete policy goals, nor even āowning the libsā with high-profile stunts. It is about assuaging the sense of fear and resentment at their America being replaced: about achieving victories that assuage the sense of psychological assault created by things like mass immigration, a Black president, shifting gender roles, and a beloved beer brand cutting an ad with a trans influencer. Donald Trump, as a figure, represents the America they know and love. His victories are their victories, his defeats their defeats. +
++This frame helps us understand why Trump canāt be beaten inside Republican politics. It also clarifies why Trump has been able to steer the Republican party so harshly against democracy. +
++By making his very person into a stand-in for the existential struggle for Americaās soul, he has created a world where any loss represents an intolerable blow against everything good about the country. Such a setback can only come from a place of deep corruption ā from the Swamp and āDemocrat-controlled cities.ā And if American democracy has truly been subverted this thoroughly, the logical conclusion is clear: We have to āfight like hellā to save it. +
++The South Carolina primaryās irrelevance points to this deeper and darker story. It is one we must wrestle with in order to truly appreciate the stakes in the coming general election. +
+Javier Milei, Nayib Bukele, and Donald Trump are all working out of the same populist playbook. +
++Meet two of the hot speakers at this yearās Conservative Political Action Conference (CPAC): Presidents Nayib Bukele of El Salvador and Javier Milei of Argentina, two of Latin Americaās most flamboyant right-wing populists. +
++CPAC started in 1974 as an annual gathering of conservatives; over the years it has turned into a days-long, livestreamed far-right spectacle. Policy is discussed and refined while movement luminaries like former President Donald Trump and House GOP Chair Elise Stefanik are given the opportunity to share their ideas with a receptive audience. +
++It might be a little sleepier than usual this year, but the conference still reveals where American conservatism is headed. And the two Latin American leadersā presence underscores the rightās continued affinity for populist and even illiberal leadership ā particularly when combined with modern personal brands built online. +
++They arenāt the first extremist leaders to speak at CPAC: Viktor OrbĆ”n of Hungary and Jair Bolsonaro of Brazil have featured in past years. Like OrbĆ”n and Bolsonaro, Bukele and Milei are staunch populists who have proposed radical solutions to serious problems in their countries. +
++The American right finds those radical proposals attractive, even if the policies likely couldnāt ā or shouldnāt ā be instituted in the US. Bukele has, seemingly, mitigated El Salvadorās serious gang violence problem through mass arrests and incarceration, while Mileiās economic policies are supposed to right Argentinaās inflation-plagued economy. +
++Trump, the presumptive Republican nominee for president, has praised both men; though he has yet to meet Milei, the former president enjoyed a friendly relationship with Bukele. Other conservative figures, including Rep.Ā Chip Roy (R-TX) of the Freedom Caucus, have praised Mileiās push for ālimitedā government. +
++The two leaders are important voices at CPAC as conservatives work to draw in Latin American voters before the election in November; Bukele in particular is popular among Salvadorans living in the US. But their presence at the conference is about more than trying to win votes, Erica Frantz, a professor of political science at Michigan State University, told Vox ā itās about creating a particular type of international far-right ideology. +
++āLinking Milei and Bukele with the Trump movement is advantageous for all parties involved,ā she said. āFor Milei and Bukele, it gives them the opportunity to strengthen an alliance with the potential presidential candidate most likely to be sympathetic to their authoritarian ambitions.ā For Trump and his supporters, āit is a chance to send a message to supporters that its style of politics is gaining steam outside US borders.ā +
++Bukele has had a long relationship with the pro-Trump right since his first presidential election in 2019. That relationship started online, among cryptocurrency enthusiasts. The ideology underlying cryptocurrency is decidedly libertarian, with many adherents calling for the abolition of treasuries and central banks. +
++Bukeleās profile rose when El Salvador began accepting bitcoin as legal tender, and heās remained popular despite the damage itās done to the countryās economy following the cryptocurrency crash of 2022. But the leaderās crypto fixation ā which is affecting the countryās ability to secure international financing ā is almost quaint in the face of his authoritarian turn, ostensibly to address the countryās serious crime problem. +
++Gangs controlled most aspects of life in the country, which was once known for having the highest murder rate in the world. With a campaign of mass arrests, Bukele has indeed tackled El Salvadorās crime problem. But that has come at a steep cost, as I explained last year: +
++++Successive presidential administrations have taken different approaches ā many have adopted the mano dura, or āiron handā tack, instituting harsh crackdowns to mitigate the violence. But Bukele is on an entirely different level; his administration has imprisoned tens of thousands, many arbitrarily, repeatedly extended a state of emergency severely curtailing the rights of ordinary citizens, and attacked and even detained his critics in the press. +
+
+The country now instead boasts the highest incarceration rate in the world. +
++Despite the human rights violations, Bukeleās policies have been popular in El Salvador. Given the astounding level of violence that ordinary people have suffered under the gangsā power ā and the rapidity with which the violence decreased ā itās not ultimately that surprising that Bukele won a second term in office, despite the fact that he has dismantled parts of El Salvadorās democracy, manipulating institutions from the countryās Constitutional Court to its legislature, to do so. +
++Though the policy appears to be working in the immediate term, critics argue it isnāt sustainable for two major reasons. The first is that Bukele has made no effort to build a long-term social or economic infrastructure as an alternative to gang violence. The second is that the sense of security people currently feel requires sacrificing other forms of security, such as the rule of law. ā[Bukeleās] popularity is built on illegality and undemocratic actions,ā Noah Bullock, the executive director of the human rights organization Cristosal, told Vox. āThere is no historic precedent where the use of state violence has produced lasting peace.ā +
++That didnāt stop Bukele from suggesting the US ought to learn from his policies during his CPAC speech on Thursday. āWe can clearly see the signs of a declining society because our own hit rock bottom decades ago,ā he told the cheering audience. He urged Americans to look at ābig cities in decline like Baltimore, Portland, New York, just to name a few places where crime and drugs have become the daily norm.ā +
++Milei has only been in office for a couple of months, so heās had less time to implement his libertarian economic policies. And he might not be able to do that much; already in his brief tenure, the congress voted down his partyās omnibus bill, which included fiscal measures aimed at managing inflation as well as an attempt to secure emergency legislative powers for, potentially, his entire four-year term. Along with deregulation and privatization efforts, the omnibus bill hinted at Mileiās social agenda: It would have reduced prenatal parental leave for women and slashed environmental protections in favor of business interests. +
++Milei will speak at the conference Saturday, most likely about his efforts to privatize state enterprises and cut down on regulations ā both topics with great appeal to CPACās audience. +
++Bukele and Milei were each granted a mandate by presenting extreme solutions to serious problems in their countries that have long frustrated citizens. But they have clear ideologies and proclivities toward illiberalism that emerge within those contexts, too. +
++āThey are able to articulate a real problem in society and propose solutions,ā Daniel Rothschild, executive director of the Mercatus Center at George Mason University, told Vox. When people are truly struggling, they respond to those policies, āeven if they are illiberal.ā +
++In his speech on Thursday evening, Bukele warned that the US was headed for the same kind of violent, gang-plagued system that defined El Salvador. But he, like Trump and other conservatives, exaggerates the problem the US faces. Trump and his allies have argued that cities (especially those in Democratic-controlled states) are full of violence, and they have also made a bogeyman out of the gang Mara Salvatrucha, or MS13, which has terrorized El Salvador along with Barrio 18. +
++It is true that MS13 actually started in the US and has had a presence here. It is also true that violent crime, including homicide, increased during the social upheaval of the pandemic, and that certain kinds of property crimes have increased. But violent crime is now at pre-pandemic levels and has trended downward overall since the 1990s. In other words, thereās simply no parallel to the violence and terror wrought by gang violence in El Salvador. +
++Itās not hard to see why Trump and others at CPAC would want to champion someone like Bukele. He exemplifies ātough on crimeā rhetoric and, to their minds, proves that the only way to avoid the āAmerican carnageā Trump warned of in his 2017 inauguration speech is to restrict human and civil rights and undo democratic norms and institutions. +
++Milei, despite having struggled to pass his policies, similarly embodies conservative ideals. His efforts to curb government spending and significantly reduce the size of the government echo the Republican partyās rhetoric of limited government and tighter belts ā but the US isnāt dealing with 140 percent inflation or a 57 percent poverty rate. +
++Itās still early in Mileiās tenure, but it is important to note that he and Bukele ā like Trump ā exemplifies what Frantz and others call a āpersonalistā leader. āThe party that supports them is intricately linked to their persona rather than a clear policy platform,ā Frantz explained. +
++Social media is an important tool in the personalist leaderās playbook that Milei, Bukele, and Trump have all used to their advantage ā they donāt have to go through establishment channels that might soften their policies or their rhetoric. +
++That social media following has created a wave of āmillennial authoritarianism,ā as researcher Manuel MelĆ©ndez-SĆ”nchez termed the phenomenon, which brands these leaders as iconoclasts who reject the āestablishment.ā +
++āWith personalist parties,ā Frantz said, āleaders pretty much have a free rein to behave as they please, and ā particularly when their party gains majority legislative representation ā the door is wide open for democracy to deteriorate.ā +
++Even if Milei is struggling to pass his policies in Argentina, heās still able to paint himself as a warrior in the fight against socialism, as he apparently will do in his CPAC speech. That will solidify his ideological link to US conservatives and show āa very clear pictureā of how far-right politicians ālearn from each other, how they are connected with each other, and they are sharing an agenda that, far from being local, is a global network,ā Paula Avila-Guillen, a human rights lawyer and executive director of the Womenās Equality Center, told Vox. +
++Ultimately, US conservatives like Bukele and Milei because they are hardliners who are using extreme tactics to deal with societyās problems ā and are willing to thumb their noses at institutions to get there. As Frantz told Vox, their presence at CPAC is āan effort to cue the conservative base to see authoritarian rhetoric as ānormalā and strongman rule as the only solution to societyās problems.ā In other words, the message is that not only is there nothing to fear from Trumpās more anti-democratic tendencies, but thereās much to gain from them. +
+The groundbreaking development speaks to the growing role of private companies in space. +
++Houston, the US is officially back on the moon. +
++On Thursday, an unmanned lunar spacecraft called Odysseus made the first US moon landing in 50 years. The spacecraft, which was produced by Texas-based engineering firm Intuitive Machines, marks major progress in the countryās ongoing investments in space exploration and provides helpful new data that can be applied to upcoming lunar missions, and even trips to Mars. +
++Odysseus is also the first private spacecraft to ever land on the moon, underscoring how American businesses are taking a more prominent role in US space endeavors. +
++Their interest and involvement in space has meant the ability to test more technology more quickly, something that has been evident in SpaceXās rocket launches, including repeated failed missions. Bolstered by government funding and a faster-moving experimental mentality, these companies are able to refine their offerings at a swifter pace than a government agency, which might often have to deal with more regulations and red tape. +
++āWeāre seeing quite a large growth in the number of companies and private interests in the space business,ā said Johns Hopkins University physics and astronomy professor Charles Bennett. +
++While private companies have long been key partners for NASA, Bennett said theyāve taken charge of more aspects of space exploration in recent years. SpaceX, for example, has become a key developer of rockets and intends to launch its own commercial missions. Additionally, the industry as a whole has seen a surge in growth and funding as more governments and consumers across the globe have become increasingly interested in space. +
++Odysseusās successful journey will ultimately be useful to scientists as they prepare for NASAās manned Artemis missions, set to travel around the moon in 2025 and land there in 2026. Those missions are dedicated to establishing a long-term US presence on the moon, with the goal of using that experience to inform later journeys to Mars. +
++Odysseus, a robotic spacecraft, touched down in the region of the moonās south pole on Thursday evening following a somewhat rocky descent. Intuitive Machines announced then on X that it was working to ādownlink the first images from the lunar surface.ā Notably, Odysseus is an autonomous spacecraft, which means it was able to land itself on the moon, a challenge that has foiled numerous past missions. +
+++After troubleshooting communications, flight controllers have confirmed Odysseus is upright and starting to send data.
+ā Intuitive Machines (@Int_Machines) February 23, 2024 +
Right now, we are working to downlink the first images from the lunar surface. +
+Odysseus will stay on the moon for about one week before itās expected to run out of power. As part of the trip, it brought six scientific experiments for NASA, including one designed to test navigation capabilities, and six commercial items, including a sculpture by artist Jeff Koons. +
++The vehicle is the first from the US to make this landing since Apollo 17 in 1972. More recently, China and Japan have also landed rovers on the moon. +
++This mission was made possible by NASAās Commercial Lunar Payload Services program and is set to aid the agencyās broader Artemis initiative, which is focused on using research on the moon to inform future missions to Mars. For this project, Intuitive Machines received $118 million in funding from NASA to build the lunar lander and transport experiments. +
++A renewed focus on the moon is driven by both commercial and scientific interests, Bennett noted. For companies that are interested in space, there could be goals of mining minerals and other resources on the moon, he says. For scientists, it could be an opportunity to study the presence of water on the moon and how it could help fuel trips to Mars. (As ABC News Australia reported, frozen water at the moonās south pole could be used to make fuel, a potentially helpful prospect for astronauts in the future.) +
++āItās really exciting,ā Geza Gyuk, the director of astronomy at the Adler Planetarium & Astronomy Museum, told CBS News. āItās part of the Artemis Project, so this is sort of testing out the technologies necessary to deliver payloads to the moon.ā +
++Additionally, these missions are taking place against an ongoing backdrop of geopolitical competition with entities including the Chinese government, which has seen three spacecraft land on the moon in the span of a decade. āIt is a fact: weāre in a space race,ā NASA Administrator Bill Nelson previously told Politico about the urgency behind the US establishing a presence on the moon. +
++In addition to Intuitive Machines, several other companies, including Elon Muskās SpaceX, Jeff Bezosās Blue Origin, and Richard Bransonās Virgin Galactic, are working on tech and vehicles for taking the next steps in space. +
++Between 2013 and 2022, private equity firms poured $272 billion into more than 1,700 private space companies, according to a Deloitte report. And the industry is only expected to grow in the next decade. +
++For now, Bennett notes that the interests of private companies and the public sector have intersected, with companies helping NASA conduct scientific experiments. He said, however, that one day those could potentially conflict. +
++At this time, the moon landing has been touted by officials as a milestone for the current private endeavors as well as public ones. āToday, for the first time in the history of humanity, a commercial company, an American company, launched and led the voyage up there,ā NASA Administrator Bill Nelson said in a video statement. āThis feat is a giant leap forward for all of humanity.ā +
+Czar, Westlake, Helios, True Punch and Ricordo shine -
One month before IPL, Sawai Man Singh Stadium and RCA office sealed by Rajasthan Sports Council - Sohan Ram Choudhary, however, gave the assurance that the venue will host the IPL matches and all other games that are slated to be organised.
Indian compound archers bag two gold medals -
Rajnath approves cash rewards for military personnel who won medals in Asian Games, Asian Para Games - For both Asian Games as well as Asian Para Games, gold medal winners will receive a cash reward of ā¹25 lakh each, silver medal winners ā¹15 lakh each and bronze medal winners ā¹10 lakh each
Leverkusen breaks Bayernās German record to go 33 games unbeaten, extends lead in Bundesliga to 11 points - The buildup to the match against Mainz was dominated by speculation over the future of Leverkusen coach Xabi Alonso, with his former clubs Bayern and Liverpool looking for new coaches for next season.
Assam Hindu group starts poster campaign against missionary schools - This followed the expiry of a deadline set by another group to remove the idols of Jesus Christ and Mother Mary from the school premises
Priest injured as school students race in Kottayam church grounds - Six out of the eight cars used by the accused were impounded by the police.
Orthodox church synod endorses Catholicosā directive proscribing clergy from party politics - The move comes in view of a series of distressing events that unfolded after one of its priests, Fr.Ā Shaiju Kurien took membership of the Bharatiya Janata Party
DDMA issues public advisory as mercury soars - This posed threats like sunburn, sunstroke and dehydration. Fire breakouts owing to piled up garbage dumps and dry grass-filled plots was another potential danger.
NIA attaches houses of 4 accused in narco-terror case in Jammu and Kashmirās Kupwara - A total of 12 accused have been arrested and 15 have been charge-sheeted so far in the case
Two years into Russiaās invasion, exhausted Ukrainians refuse to give up - Ukrainians may be fatigued by the war, but they still see it as a fight for survival.
Spanish police search gutted flats after nine killed - Cladding as well as high winds are being blamed for the flame in the 14-floor complex in Valencia.
Ukraine says it has downed second Russian spy plane - An A-50 radar detection aircraft is reportedly shot down over Russia, more than 200km from the front line.
Eight in hospital after smell at Sweden security HQ - Hundreds of security service workers are evacuated after reports of an unusual smell in the building.
Germany legalises cannabis, but makes it hard to buy - Under the law backed by MPs, possession will be legal, but strict rules mean it will be complicated.
Yelp: Itās gotten worse since Google made changes to comply with EU rules - Users are even more likely to stick with Google due to one change, says Yelp. - link
RTO doesnāt improve company value, but does make employees miserable: Study - Data is consistent with bosses using RTO to reassert control and scapegoat workers. - link
Vending machine error reveals secret face image database of college students - Facial-recognition data is typically used to prompt more vending machine sales. - link
Plucky crew of Star Trek: Discovery seeks a strange artifact in S5 trailer - āIt has been a hell of a journey. But everything ends someday.ā - link
Avast ordered to stop selling browsing data from its browsing privacy apps - Identifiable data included job searches, map directions, ācosplay erotica.ā - link
I got arrested in Alabama on a million counts of murder. -
++I jerked off. +
+ submitted by /u/JoeFas
[link] [comments]
A friend was bragging to me that he was having sex with a girl and also her twin.I askedā¦.How can you tell them apart? -
++He repliedā¦her brother has a moustache! +
+ submitted by /u/berkleysquare
[link] [comments]
I boarded a crowded flight the other day and I saw an empty seat next to this guyā¦ā¦ -
++I sat down, took off my shoes, and cracked open a beer. I was just starting to relax when the guy gets really angry and starts swearing at me. The next thing I know the police are throwing me off the plane! Fucking pilots. No chill. +
+ submitted by /u/icecreamivan
[link] [comments]
A rabbi, a priest, and a minister are playing poker when the cops raid the game. -
++The lead officer questions the priest, āFather Murphy, were you gambling? +
++Father Murphy silently asks God to forgive him for what he is about to say. āNo, Officer. I was not gambling.ā +
++The cop turns to the minister, āPastor Johnson, were you gambling?ā +
++Pastor Johnson also appeals to Heaven. āNo, Officer. I was not gambling.ā +
++The cop finally turns to the rabbi. āRabbi Goldstein, were you gambling?ā +
++āGambling?ā he asks, glancing at the priest and the minister. āWith who?ā +
+ submitted by /u/peacheatery
[link] [comments]
A minister, a priest, and a rabbi are debating whose religion is the one true religion. -
++To settle this once for all, the priest suggests they all go out into the woods and convert a bear to their religion. Whoever converts a bear would be the deemed the winner. The three agree to the terms, and head out into the woodsā¦ +
++A week later, the priest and the minister meet back up. The minister asks āSo howās your bear doing?ā +
++The priest says, āMy bear has already started the Bible. He should be done with it soon.ā +
++The minister says, āOh, thatās nothing. My bearās already finished the Bible. Iām baptizing him next Sunday.ā +
++The rabbi walks up covered in bruises and cuts, and one of his arms is in a sling. +
++āOh my God, what happed to you?ā said the minister. +
++The rabbi says, āYou know, thinking back, I probably shouldnāt have started with the circumcision.ā +
+ submitted by /u/Plutopiter
[link] [comments]