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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Evolutionary trajectory of the physicochemical mechanism of interaction of SARS-CoV-2 spike protein with ACE2</strong> -
<div>
SARS-CoV-2 infects cells by attachment to its receptor the angiotensin converting enzyme 2 (ACE2). Regardless of the wealth of structural data, little is known about the physicochemical mechanism of interactions of the viral spike (S) protein with ACE2 and how this mechanism has evolved during the pandemic. Here, we applied experimental and computational approaches to characterize the molecular interaction of S proteins from SARS-CoV-2 variants of concern (VOC). Data on kinetics, activation- and equilibrium thermodynamics of binding of the receptor binding domain (RBD) from VOC with ACE2 as well as data from computational protein electrostatics revealed a profound remodeling of the physicochemical characteristics of the interaction during the evolution. Thus, as compared to RBDs from Wuhan strain and other VOC, Omicron RBD presented as a unique protein in terms of conformational dynamics and types of non-covalent forces driving the complex formation with ACE2. Viral evolution resulted in a restriction of the RBD structural dynamics, and a shift to a major role of electrostatic forces for ACE2 binding. Further, we investigated how the reshaping of the physicochemical qualities affect the functional properties of S proteins. Data from various binding assays revealed that SARS-CoV-2 Wuhan and Omicron RBDs manifest capacity for off-target (promiscuous) recognition of multiple unrelated proteins, but they harbor distinct reactivity patterns. This study provides mechanistic explanations for changes in the viral tropism, infectivity, and capacity to evade immune responses during evolution.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.11.495733v1" target="_blank">Evolutionary trajectory of the physicochemical mechanism of interaction of SARS-CoV-2 spike protein with ACE2</a>
</div></li>
<li><strong>The Effect of Perceived Workplace Bureaucracies on Self-Evaluated Efficacy, Job Satisfaction and Motivation in the Workplace during the COVID-19 Pandemic</strong> -
<div>
Workplace bureaucracies impact many areas of an employee’s life. Perceived high levels of bureaucracy can negatively impact employees’ job motivation, satisfaction, and performance. During the COVID-19 pandemic, infection containment measures may have contributed to the factors underlying the “great resignation” via the lack of self-efficacy from perceived bureaucracy. Recruiting 240 full-time employees in late 2021 to early 2022 across organisations in both private and public sectors in Singapore online with the Work Extrinsic Intrinsic Motivation Scale, the Workplace Bureaucracy Questionnaire and the General Self-Efficacy Scale among demographic parameters, 228 participants were analysed after removal of missing data. Salary range, education levels, employee self-efficacy and job motivation were found to be negatively associated with perceived workplace bureaucracies but not gender, age, and length of service. The findings of the study may provide insight into the mechanism of increased perceived bureaucracy during the COVID-19 pandemic on the employee experience that would be relevant to the workplace environment during in normal times.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/y83ze/" target="_blank">The Effect of Perceived Workplace Bureaucracies on Self-Evaluated Efficacy, Job Satisfaction and Motivation in the Workplace during the COVID-19 Pandemic</a>
</div></li>
<li><strong>Un nuevo urbanismo para Europa: los fondos europeos de recuperación y su proyección en el futuro de las ciudades - A NEW URBANISM FOR EUROPE: THE EUROPEAN RECOVERY FUNDS, AND THEIR IMPACT ON THE FUTURE OF CITIES</strong> -
<div>
The Next Generation EU (NGEU) fund is a European Union economic recovery package to support member states adversely impacted by the COVID-19 pandemic. This program represents an unprecedented effort. Besides promoting a European Union more ecological, digital, and resilient, the recovery funds aim at financing projects of public-private partnership around a series of issues. Some especially related to urbanism, such as ecological transition, smart, sustainable, integrative growth, or social and territorial cohesion. In the first part of the present work, we analyze the evolution of urbanism in Europe since the 1972 European Soil Charter, adopted by the Council of Europe in Strasbourg. Secondly, we examine potential areas where urban projects could be promoted implementing European funds, in connection with the new Leipzig Charter and the European Territorial Agenda 2030, which support an urban environment more just, green, and productive.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/bypk5/" target="_blank">Un nuevo urbanismo para Europa: los fondos europeos de recuperación y su proyección en el futuro de las ciudades - A NEW URBANISM FOR EUROPE: THE EUROPEAN RECOVERY FUNDS, AND THEIR IMPACT ON THE FUTURE OF CITIES</a>
</div></li>
<li><strong>SARS-CoV-2 minor variant genomes at the start of the pandemic contained markers of VoCs</strong> -
<div>
SARS-CoV-2 emerged through limited zoonotic spillovers and was predicted to have constrained sequence diversity. The dominant consensus and minor variant genomes were determined from the earliest samples associated with the Huanan market and the start of the pandemic. The sequence data confirmed that the dominant consensus genomes shared very close homology. However, there were minor variant genomes present in each sample, which encompassed synonymous and non-synonymous changes. Fusion sequences characteristic of defective RNAs were identified that could be linked between patients. Several substitutions (but not deletions) associated with much later variants of concern (VoCs) were already present as minor variant genomes. This suggests it may be possible to predict futures variants at the start of a pandemic by examining where variability in sequence occurs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.10.495670v1" target="_blank">SARS-CoV-2 minor variant genomes at the start of the pandemic contained markers of VoCs</a>
</div></li>
<li><strong>Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection</strong> -
<div>
The global effort to sequence millions of SARS-CoV-2 genomes has provided an unprecedented view of viral evolution. Characterizing how selection acts on SARS-CoV-2 is critical to developing effective, long-lasting vaccines and other treatments, but the scale and complexity of genomic surveillance data make rigorous analysis challenging. To meet this challenge, we develop Bayesian Viral Allele Selection (BVAS), a principled and scalable probabilistic method for inferring the genetic determinants of differential viral fitness and the relative growth rates of viral lineages, including newly emergent lineages. After demonstrating the accuracy and efficacy of our method through simulation, we apply BVAS to 6.9 million SARS-CoV-2 genomes. We identify numerous mutations that increase fitness, including previously identified mutations in the SARS-CoV-2 Spike and Nucleocapsid proteins, as well as mutations in non-structural proteins whose contribution to fitness is less well characterized. In addition, we extend our baseline model to identify mutations whose fitness exhibits strong dependence on vaccination status as well as pairwise interaction effects, i.e. epistasis. Strikingly, both these analyses point to the pivotal role played by the N501 residue in the Spike protein. Our method, which couples Bayesian variable selection with a diffusion approximation in allele frequency space, lays a foundation for identifying fitness-associated mutations under the assumption that most alleles are neutral.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.05.07.490748v2" target="_blank">Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection</a>
</div></li>
<li><strong>Can starch-based diet or sugar water put an end to the COVID-19 pandemic?</strong> -
<div>
High valine plus glycine content is a feature of the proteins in SARS-CoV-2 and SARS viruses, and it causes the generation of aggregates between proteins and insoluble calcium salts via secondary chemical bonding. Starch-based diet or sugar water with adequate vitamins can go for many days without the generation of essential amino acids such as valine, creating bottlenecks in virion production in human body. Despite its potential carcinogenicity, modest lysine supplement can be favorable as lysine rich proteins gather chloride and solubilize stressful, insoluble and stiff calcium oxalate and calcium phosphate.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/shmk3/" target="_blank">Can starch-based diet or sugar water put an end to the COVID-19 pandemic?</a>
</div></li>
<li><strong>The Prospective Relationship between Loneliness, Life Satisfaction, and Psychological Distress before and during the COVID-19 Pandemic in the UK</strong> -
<div>
Background Mental wellbeing in the UK seems to have deteriorated significantly during the COVID-19 pandemic, with the rates of loneliness, life satisfaction, and psychological distress taking longer to return to the pre-pandemic levels than elsewhere. Nevertheless, there is little knowledge about the interactions between these outcomes, or the factors that played a role. Methods Longitudinal data from Understanding Society (N=3475) were used to explore the changes in loneliness, life satisfaction, and psychological distress from pre-pandemic levels (2017-19) through November 2020, the interactions between these outcomes, and the role of individual differences in the rates of change, using multivariate latent growth curve model. Results Loneliness, life satisfaction, and psychological distress deteriorated minimally between April and November 2020, compared to the pre-pandemic levels (2017-2019), while the rate of change in each outcome influenced the rate of change in the other two. Key individual (age, gender, physical health), social (number of friends) and environmental (neighbourhood quality) variables influenced baseline scores and the rates of change. Conclusion Considering significant dynamic associations between loneliness, life satisfaction, and psychological distress, we argue that interventions to tackle any one of the outcomes may have beneficial effects on others, while highlighting individual and community-level interventions to tackle loneliness.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/5r4vw/" target="_blank">The Prospective Relationship between Loneliness, Life Satisfaction, and Psychological Distress before and during the COVID-19 Pandemic in the UK</a>
</div></li>
<li><strong>Experiences of First Year University Students Regarding Institutional Mentoring Programme during COVID-19 Outbreak: A Qualitative Evidence Synthesis</strong> -
<div>
Universities had to ensure that students were well supported during the COVID-19 pandemic. Over the years, peer mentors have provided one-on-one psychosocial support to first-year students. Following the outbreak of COVID-19, it became difficult to provide face-to-face assistance. As a result, new forms of communities, networks, and interactions, that student can develop and participate in, emerged to cope with the crisis. The problem is that students encounter unexpected challenges from the moment they arrive at university, owing to the substantial shift in roles and complex responsibilities that comes with being a student at a university. The purpose of this study is to investigate students’ first-year experiences during the COVID-19 outbreak so as to provide insights that could be useful for institutional policy and practice. The study was undertake a Qualitative Evidence Systematic Review, which is a summary of research literature focused on a single subject that claims the role of systematic reviews in evidence-based practices. A qualitative meta-synthesis was conducted using the PICO framework (Population/Place; Intervention; Comparator; Outcome) so as to seek to answer the question: “What are the experiences of first-year university students regarding the institutional mentoring programme during the Covid-19 Outbreak?” Articles were critically reviewed for eligibility using the PRISMA flow diagram, with relevance screening and duplicate removal using the CASP assessment tool. This is a method that allows the researcher to evaluate data both deductively and interpretively to better understand phenomena. In total fifteen articles were selected for this study; they were chosen through purposive sampling and then subjected to thematic analysis. The findings of this study are expected to add to the existing body of knowledge on the first-year university student experience.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/africarxiv/ajmkp/" target="_blank">Experiences of First Year University Students Regarding Institutional Mentoring Programme during COVID-19 Outbreak: A Qualitative Evidence Synthesis</a>
</div></li>
<li><strong>The impact of COVID-19 pandemic on bronchiolitis (lower respiratory tract infection) due to respiratory syncytial virus: A systematic review and meta-analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objective This systematic review and meta-analysis aimed to quantitatively evaluate the effect of the COVID-19 pandemic on respiratory syncytial virus (RSV) associated bronchiolitis among hospitalised infants. Methods The study protocol was registered in the PROSPERO database (CRD42022314000) and was designed based on PRISMA guidelines updated in May 2020. The meta-analysis component was modified appropriately to synthesise the pooled proportion of infants having RSV-associated bronchiolitis before the COVID-19 pandemic in 2019 and during the pandemic with 95% confidence interval (CI). Results: The eight qualified studies for the meta-analysis were from Spain, Italy, France and China, including 109,186 symptomatic cases of bronchiolitis before the pandemic in 2019 and 61,982 cases in 2020-2021. The quantitative analysis included laboratory-confirmed RSV infection in 7691 infants with bronchiolitis reported before the pandemic in 2019. Meanwhile, during the pandemic, 4964 cases were associated with RSV infection. The pooled proportion of RSV-associated bronchiolitis cases before the pandemic in 2019 was 16.74% (95% CI 11.73-22.43%). The pooled proportion of confirmed RSV cases during the pandemic in 2020/2021 was 19.20 % (95% CI 12.01-27.59%). Conclusion There was an increase in RSV activity after the relaxation of stringent public health measures during the COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.04.26.22274244v6" target="_blank">The impact of COVID-19 pandemic on bronchiolitis (lower respiratory tract infection) due to respiratory syncytial virus: A systematic review and meta-analysis</a>
</div></li>
<li><strong>The impact of COVID-19 pandemic on influenza surveillance: a systematic review and meta-analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Influenza activity was reported to be below the seasonal levels during the COVID-19 pandemic globally. However, during the SARS-CoV-2 outbreak, the routine real-time surveillance of influenza like illness (ILI) and acute respiratory infection (ARI) was adversely affected due to the changes in priorities, economic constraints, repurposing of hospitals for COVID care and closure of outpatient services. A systematic review and meta-analysis were carried out to assess the pooled proportion of symptomatic cases tested for influenza virus before the COVID-19 pandemic in 2019 and during the pandemic in 2020/2021. The study was designed based on PRISMA guidelines and the meta-analysis was performed to synthesise the pooled proportion of patients sampled for influenza surveillance before the COVID-19 pandemic in 2019 and during the pandemic in 2020/21 with 95% confidence interval (CI). The overall pooled proportion of symptomatic cases undergone influenza surveillance before and during the pandemic was 2.38% (95% CI 2.08%-2.67%) and 4.18% (95% CI 3.8%-4.52%) respectively. However, the pooled proportion of samples tested for influenza before the pandemic was 0.69% (95% CI 0.45-0.92%) and during the pandemic was 0.48% (95% CI 0.28-0.68%) when studies from Canada were excluded. The meta-analysis concludes that globally there was a decline in influenza surveillance during the COVID-19 pandemic except in Canada.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.31.22273236v4" target="_blank">The impact of COVID-19 pandemic on influenza surveillance: a systematic review and meta-analysis</a>
</div></li>
<li>**Spike-Induced Disturbances (SPAS*): An Analysis of Common Suspected Adverse Experiences Associated With Covid-19 Vaccines** -
<div>
This review/analysis gives a first impression of numerous adverse events related to Covid-19 vaccination, which have received little attention to date, are often unexplained, but are nevertheless very distressing. Frequently observed organ-related ADRs after Covid-19 vaccination were such of the nervous system, musculoskeletal system, gastrointestinal tract, and skin. The involvement of almost all organs in the side effect spectrum of Covid-19 vaccines demonstrates their systemic efficacy. As shown by the ADRs occurrence even after numerous days to weeks, the duration of spike production obviously lasts longer than claimed. The key role is played by the interaction between the spike subunit S1 and the membrane-bound enzyme ACE2, the receptor for SARS-CoV. Downregulation of ACE2 by spikes and following activation of RAAS can lead to numerous clinically relevant disorders, such as vasoconstriction, tissue ischemia, induction of proliferative processes, increased oxidative stress, inflammation, or coagulation disorders, as previously shown for cardiovascular reactions. It is proposed to use the collective term “SPAS” (in German: Spike ausgelöste Störungen) - spike induced disturbances for side effects based on this mode of action. The common mode of action and only slightly different frequencies of adverse events and fatal outcomes do not indicate any principal differences in adverse event profiles of the individual spike-based Covid-19 vaccines. A class-specific side effect profile can be assumed. Knowledge and awareness of the comprehensive adverse event profile of the novel Covid-19 vaccines and their potential dangerousness may improve vaccine safety.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/q94bn/" target="_blank">Spike-Induced Disturbances (SPAS*): An Analysis of Common Suspected Adverse Experiences Associated With Covid-19 Vaccines</a>
</div></li>
<li><strong>A cellular assay for spike/ACE2 fusion: quantification of fusion-inhibitory antibodies after COVID-19 and vaccination</strong> -
<div>
Not all antibodies against SARS-CoV-2 inhibit viral entry and hence infection. Neutralizing antibodies are more likely to reflect real immunity, however certain of these tests investigate protein/protein interaction rather than the fusion event. Viral and pseudoviral entry assays detect functionally active antibodies, however they are cumbersome and burdened by biosafety and standardization issues. We have developed a Spike/ACE2-dependant cell-to-cell fusion assay, based on a split luciferase. Hela cells stably transduced with Spike and a large fragment of luciferase were co-cultured with Hela cells transduced with ACE2 and the complementary small fragment of luciferase. Within 24h, cell fusion occured allowing the measurement of luminescence. Light emission was abolished in the absence of Spike and reduced in the presence of an inhibitor of Spike-processing proteases. Serum samples from COVID-19-negative, non-vaccinated individuals, or sera from patients at the moment of first symptoms did not lead to a significant reduction of fusion. In contrast, sera from COVID-19-positive patients as well as sera from vaccinated individuals reduced the fusion. In conclusion, we report a new method measuring fusion-inhibitory antibodies in serum, combining the advantage of a functional full Spike/ACE2 interaction with a high degree of standardization, easily allowing automation in a standard bio-safety environment.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.09.495433v1" target="_blank">A cellular assay for spike/ACE2 fusion: quantification of fusion-inhibitory antibodies after COVID-19 and vaccination</a>
</div></li>
<li><strong>Tracking infectious entry routes of SARS-CoV-2</strong> -
<div>
SARS-CoV-2 cell entry starts with membrane attachment and ends with spike-protein (S) catalyzed membrane fusion depending on two cleavage steps, one usually by furin in producing cells and the second by TMPRSS2 on target cells. Endosomal cathepsins can carry out both. Using real-time 3D single virion tracking, we show fusion and genome penetration requires virion exposure to an acidic milieu of pH 6.2-6.8, even when furin and TMPRSS2 cleavages have occurred. We detect the sequential steps of S1-fragment dissociation, fusion, and content release from the cell surface in TMPRRS2 overexpressing cells only when exposed to acidic pH. We define a key role of an acidic environment for successful infection, found in endosomal compartments and at the surface of TMPRSS2 expressing cells in the acidic milieu of the nasal cavity.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.09.495472v1" target="_blank">Tracking infectious entry routes of SARS-CoV-2</a>
</div></li>
<li><strong>Binding and unbinding pathways of peptide substrate on SARS-CoV-2 3CL protease</strong> -
<div>
Based on many crystal structures of ligand complexes, much study has been devoted to understanding the molecular recognition of SARS-CoV-2 3C-like protease (3CLpro), a potent drug target for COVID-19. In this research, to extend this present static view, we examined the kinetic process of binding/unbinding of an eight-residue substrate peptide to/from 3CLpro by evaluating the path ensemble with the weighted ensemble simulation. The path ensemble showed the mechanism of how a highly flexible peptide folded into the bound form. At the early stage, the dominant motion was the diffusion on the protein surface showing a broad distribution, whose centre was led into the cleft of the Chymotrypsin fold. We observed a definite sequential formation of the hydrogen bonds at the later stage occurring in the cleft, initiated between Glu166 (3CLpro) and P3_Val (peptide), followed by binding to the oxyanion hole and completed by the sequence-specific recognition at P1_Gln.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.08.495396v1" target="_blank">Binding and unbinding pathways of peptide substrate on SARS-CoV-2 3CL protease</a>
</div></li>
<li><strong>SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.</strong> -
<div>
Secretory immunoglobulin A (IgA) plays a crucial role in the mucosal immunity for preventing the invasion of the exogenous antigens, however, little has been understood about the neutralizing activity of serum IgA. Here, to examine the role of IgA antibodies against COVID-19 illnesses, we determined the neutralizing activity of serum/plasma IgG and IgA purified from previously SARS-CoV-2-infected and COVID-19 mRNA-vaccine-receiving individuals. We found that serum/plasma IgA possesses substantial but rather modest neutralizing activity against SARS-CoV-2 compared to IgG with no significant correlation with the disease severity. Neutralizing IgA and IgG antibodies achieved the greatest activity at approximately 25 and 35 days after symptom onset, respectively. However, neutralizing IgA activity quickly diminished and went down below the detection limit approximately 70 days after onset, while substantial IgG activity was observed till 200 days after onset. The total neutralizing activity in sera/plasmas of those with COVID-19 largely correlated with that in purified-IgG and purified-IgA and levels of anti-SARS-CoV-2-S1-binding IgG and anti-SARS-CoV-2-S1-binding IgA. In individuals who were previously infected with SARS-CoV-2 but had no detectable neutralizing IgA activity, a single dose of BNT162b2 or mRNA-1273 elicited potent serum/plasma neutralizing IgA activity but the second dose did not further strengthen the neutralization antibody response. The present data show that the systemic immune stimulation with natural infection and COVID-19 mRNA-vaccines elicit both SARS-CoV-2-specific neutralizing IgG and IgA response in serum, but the IgA response is modest and diminishes faster compared to IgG response.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.09.495422v1" target="_blank">SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase I Clinical Trial of GEN2-Recombinant COVID-19 Vaccine (CHO Cells) in Healthy People Aged 18 and Above</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Biological: Experimental Vaccine 1;   Biological: Experimental Vaccine 2;   Biological: Experimental Vaccine 3;   Biological: placebo<br/><b>Sponsors</b>:   National Vaccine and Serum Institute, China;   Lanzhou Institute of Biological Products Co., Ltd;   Beijing Institute of Biological Products Co Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Algorithm Treatment at Home</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Recommended treatment schedule;   Drug: Usual care<br/><b>Sponsor</b>:   Mario Negri Institute for Pharmacological Research<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eucalyptus Oil as Adjuvant Therapy for Coronavirus Disease 19 (COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Eucalyptus Oil;   Drug: Standard COVID medication<br/><b>Sponsors</b>:   Hasanuddin University;   Ministry of Agriculture, Republic of Indonesia<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19</strong> - <b>Condition</b>:   Asymptomatic COVID-19<br/><b>Interventions</b>:   Drug: Cepharanthine;   Drug: Placebo<br/><b>Sponsors</b>:   Shanghai Jiao Tong University School of Medicine;   YUNNAN BAIYAO GROUP CO.,LTD<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Epidemiological Monitoring of COVID-19 Patients Hospitalized on Reunion Island</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: telephone interview 24 months after hospitalization for Covid-19<br/><b>Sponsor</b>:   Centre Hospitalier Universitaire de la Réunion<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Real-time Quaking-Induced Conversion (RT-QuIC)<br/><b>Sponsor</b>:   Medical University Innsbruck<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Randomized, Single-blinded, Multicenter Trial Comparing the Immune Response to a 2nd Booster Dose of COVID-19 mRNA Vaccine (Pfizer-BioNTech) or Sanofi /GSK B.1.351 Adjuvanted Vaccine in Adults</strong> - <b>Condition</b>:   COVID-19 Vaccines<br/><b>Interventions</b>:   Biological: 2nd booster with Comirnaty® (Pfizer-BioNTech);   Biological: CoV2 preS dTM adjuvanted vaccine (B.1.351), Sanofi/GSK<br/><b>Sponsors</b>:   Assistance Publique - Hôpitaux de Paris;   IREIVAC/COVIREIVAC Network<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety of a Third Dose of COVID-19 Vaccine(Vero Cell), Inactivated in the Elderly</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: COVID-19 Vaccine (Vero cell), Inactivated<br/><b>Sponsor</b>:   Sinovac Life Sciences Co., Ltd.<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy, Safety and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)(Recov)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant two-component COVID-19 vaccine (CHO cell);   Biological: Placebo<br/><b>Sponsor</b>:   Jiangsu Rec-Biotechnology Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety Study of Booster Vaccine With the COVID-19 Vaccine (Vero Cell), Inactivated, Omicron Strain</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: COVID-19 Vaccine (Vero Cell), Inactivated, Omicron Strain<br/><b>Sponsor</b>:   Sinovac Biotech (Hong Kong) Limited<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 1b Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: RQ3013;   Biological: Comirnaty<br/><b>Sponsors</b>:   Walvax Biotechnology Co., Ltd.;   Shanghai RNACure Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Plerixafor in Acute Respiratory Distress Syndrome Related to COVID-19 (Phase IIb)</strong> - <b>Conditions</b>:   COVID-19 Acute Respiratory Distress Syndrome;   COVID-19<br/><b>Interventions</b>:   Drug: Plerixafor 20 MG/ML [Mozobil];   Other: Placebo<br/><b>Sponsor</b>:   4Living Biotech<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Telerehabilitative Aerobic and Relaxation Exercises Patients With Type 2 Diabetes With and Without COVID-19</strong> - <b>Conditions</b>:   COVID-19;   Type 2 Diabetes Mellitus<br/><b>Intervention</b>:   Other: Aerobic and Relaxation Exercises<br/><b>Sponsor</b>:   Bozyaka Training and Research Hospital<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Long Haul COVID Rehabilitation &amp; Recovery Research Program</strong> - <b>Condition</b>:   Long Haul COVID or Post Acute Sequella of COVID - PASC (U09.9)<br/><b>Intervention</b>:   Other: Virtual vs On Site Pulmonary Rehabilitation<br/><b>Sponsor</b>:   Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of Bradykinin in COVID-19 Infection With Icatibant</strong> - <b>Condition</b>:   SARS CoV 2 Infection<br/><b>Interventions</b>:   Drug: Icatibant;   Drug: 0.9% Sodium Chloride Injection<br/><b>Sponsors</b>:   Belfast Health and Social Care Trust;   Queen’s University, Belfast<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prevalence of alcohol-tolerant and antibiotic-resistant bacterial pathogens on public hand sanitizer dispensers</strong> - CONCLUSION: HSDs serve as potential breeding grounds for dissemination of pathogens and antibiotic resistance across unknowing users. Proper HSD maintenance will ensure protection of public health and sustainable use of sanitizing alcohols, to prevent emergence of alcohol-resistant pathogens.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Risk stratification models for stroke in patients hospitalized with COVID-19 infection</strong> - CONCLUSIONS: We developed a practical clinical score, with similar performance to machine learning estimators, to help stratify stroke risk among patients hospitalized with COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition</strong> - Highly pathogenic human coronaviruses (CoV) including SARS-CoV, MERS-CoV and SARS-CoV-2 have emerged over the past two decades, resulting in infectious disease outbreaks that have greatly affected public health. The CoV surface spike (S) glycoprotein mediates receptor binding and membrane fusion for cell entry, playing critical roles in CoV infection and evolution. The S glycoprotein is also the major target molecule for prophylactic and therapeutic interventions, including neutralizing…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding region</strong> - The outbreak of COVID-19 has resulted in millions of deaths. Despite all attempts that have been made to combat the pandemic, the re-emergence of new variants complicated SARS-CoV-2 eradication. The ongoing global spread of COVID-19 demands the incessant development of novel agents in vaccination, diagnosis, and therapeutics. Targeting receptor-binding domain (RBD) of spike protein by which the virus identifies host receptor, angiotensin-converting enzyme (ACE2), is a promising strategy for…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of novel SARS-CoV-2 inhibitors targeting the main protease M<sup>pro</sup> by virtual screenings and hit optimization</strong> - Two years after its emergence, SARS-CoV-2 still represents a serious and global threat to human health. Antiviral drug development usually takes a long time and, to increase the chances of success, chemical variability of hit compounds represents a valuable source for the discovery of new antivirals. In this work, we applied a platform of variably oriented virtual screening campaigns to seek for novel chemical scaffolds for SARS-CoV-2 main protease (M^(pro)) inhibitors. The study on the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators</strong> - BACKGROUND: Bromodomain and extraterminal proteins (BETs) are more than just epigenetic regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the maintenance of higher order chromatin structure at Topologically Associating Domain Boundaries (TADBs). BD2-selective and pan (non-selective) BET inhibitors (BETi) differentially support chromatin structure, selectively affecting transcription and cell viability.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Conjugation with 8-arm PEG and CRM<sub>197</sub> enhances the immunogenicity of SARS-CoV-2 ORF8 protein</strong> - Safe and effective vaccines are urgently needed to combat the COVID-19 pandemic. However, the SARS-CoV-2 variants raise concerns about the effectiveness of vaccines. As a SARS-CoV-2 antigen target, ORF8 strongly inhibits the IFN-β and NF-κB-responsive promoter, and can be potentially used for the development of SARS-CoV-2 vaccine. However, it is necessary to improve the immunogenicity of ORF8 by adjuvants or delivery systems. CRM(197) was a carrier protein with the ability to activate T helper…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bovine colostrum-derived antibodies against SARS-CoV-2 show great potential to serve as prophylactic agents</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to impose a serious burden on health systems globally. Despite worldwide vaccination, social distancing and wearing masks, the spread of the virus is ongoing. One of the mechanisms by which neutralizing antibodies (NAbs) block virus entry into cells encompasses interaction inhibition between the cell surface receptor angiotensin-converting enzyme 2 (ACE2) and the spike (S) protein of SARS-CoV-2. SARS-CoV-2-specific NAb…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Commentary: University Technology Transfer Has Made a Significant Contribution to Fighting COVID-19 while Ensuring Global Access</strong> - This paper reviews the response by public sector research organizations and their technology transfer offices to the COVID-19 pandemic. It shows that leading universities and technology transfer associations quickly enacted licensing principles for the duration of the pandemic to maximize availability and minimize delays in translating public sector research institutes’ (PSRIs’) COVID-19 inventions to the public - in both the developed and the developing world - while waiving payment of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential therapeutic effects of Ivermectin in COVID-19</strong> - COVID-19 is a critical pandemic that affected communities around the world, and there is currently no specific drug treatment for it. The virus enters the human cells via spikes and induces cytokine production and finally arrests the cell cycle. Ivermectin shows therapeutic potential for treating COVID-19 infection based on in vitro studies. Docking studies have shown a strong affinity between Ivermectin and some virulence factors of COVID-19. Notably, clinical evidence has demonstrated that…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus Disease 2019 Vaccine Booster Effects Are Seen in Human Milk Antibody Response</strong> - Infants remain at high risk for severe coronavirus disease 2019 (COVID-19). Human milk contains high levels of protective SARS CoV-2 specific antibodies post-infection and primary vaccine series, but levels decline over time. We hypothesized that the COVID-19 booster vaccine augment antibody production and the protection afforded to human milk-fed infants. We prospectively enrolled pregnant or lactating mothers planning to receive COVID-19 vaccination. We measured human milk IgG, IgA, and IgM…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Modeling and Simulation Analysis of Antimicrobial Photodynamic Therapy Potential for Control of COVID-19</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the host cells by binding the viral surface spike glycoprotein (SG) to angiotensin-converting enzyme 2. Since antiviral photodynamic therapy (aPDT) has been described as a new method for inhibiting viral infections, it is important to evaluate whether it can be used as a photoactivated disinfectant to control COVID-19. In this in silico study, SARS-CoV-2-SG was selected as a novel target for curcumin as a photosensitizer…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein</strong> - Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. Therapy for ITP relies on competing and inhibiting the autoantibody binding and destruction (intravenous immunoglobulin and anti-D immunoglobulin and spleen tyrosine kinase (Syk) inhibitor fostamatinib), augmenting platelet production…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Development and Validation of an HPLC-UV Method for the Quantification of 4’-Hydroxydiclofenac Using Salicylic Acid: Future Applications for Measurement of In Vitro Drug-Drug Interaction in Rat Liver Microsomes</strong> - Salicylic acid is a key compound in nonsteroidal anti-inflammatory drugs that has been recently used for preventing the risk of hospitalization and death among COVID-19 patients and in preventing colorectal cancer (CRC) by suppressing two key proteins. Understanding drug-drug interaction pathways prevent the occurrence of adverse drug reactions in clinical trials. Drug-drug interactions can result in the variation of the pharmacodynamics and pharmacokinetic of the drug. Inhibition of the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from <em>Burkillanthus</em>&amp;amp;nbsp;<em>malaccensis</em> (Ridl.) Swingle</strong> - The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthusmalaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthusmalaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bark, wood, pericarps, and endocarps were tested against bacteria by broth microdilution assay and their antibiotic-potentiating activities….</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dishonor, Trump’s and His Party’s, Is the Real January 6th Takeaway</strong> - Liz Cheney, defying the G.O.P., offered a searing indictment of the former President at Thursday’s hearing. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/dishonor-trumps-and-his-partys-is-the-real-january-6th-takeaway">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why San Francisco Fired Chesa Boudin</strong> - Does the district attorney’s recall reveal the limitations of progressive criminal-justice reform? - <a href="https://www.newyorker.com/news/the-political-scene/why-san-francisco-fired-chesa-boudin">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hiding Buffalo’s History of Racism Behind a Cloak of Unity</strong> - Officials have described the recent shooting as an aberration in the “City of Good Neighbors.” But this conceals the city’s long-standing racial divisions. - <a href="https://www.newyorker.com/news/our-columnists/hiding-buffalos-history-of-racism-behind-a-cloak-of-unity">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Did Guns Get So Powerful?</strong> - Decade by decade, firearms have become deadlier—and tightened their grip on our collective imagination. - <a href="https://www.newyorker.com/tech/annals-of-technology/how-did-guns-get-so-powerful">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Maestro of Madison Square Garden</strong> - From a perch atop the arena, Ray Castoldi, the organist for the Rangers, improvises the soundtrack for playoff-hockey agony and ecstasy. - <a href="https://www.newyorker.com/sports/sporting-scene/the-maestro-of-madison-square-garden">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The best $2,618 I ever spent: A second wedding ceremony</strong> -
<figure>
<img alt="An illustration of a wedding invitation atop its envelope." src="https://cdn.vox-cdn.com/thumbor/yjDB5rYLQzomQpo9kiVGnFM4PNs=/500x0:3500x2250/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70968250/Wedding.0.jpg"/>
<figcaption>
I was fiercely independent, and didn’t have faith I could care for anyone else. But Antoinette always believed in me. | Dana Rodriguez for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Six months after I nearly destroyed our first $26,112 day.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8n5biw">
Four days after we walked down the aisle for the first time, my wife Antoinette and I cruised off on our honeymoon to Cozumel, Mexico. On our second night, we found ourselves sitting in a theater full of our fellow passengers as contestants on a knockoff version of the ’60s game show, <em>The Newlywed Game</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="meNBrA">
The first question was easy — “Where was your first date?”— but they devolved quickly: Which in-law would you least like to be stuck on a deserted island with? Which movie best describes your love life? What is your husband’s most annoying habit?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KHcCuG">
We got every question correct, and every answer was filled with resentment. Our first date was a 1930s diner outing at Quintessence, a Cap City landmark. We both deemed our love life to be akin to <em>Pee-wee’s Big Adventure</em>, and my wife offered three things she despised about me: how I wiped my nose with my finger, my nail munching, and how I was overall a neurotic nebbish.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iPELiL">
We were suffering from the fallout of the past year: everything leading to what would be our first wedding ceremony. I didn’t deal well with change, and a wedding changes everything. It changes your family structure, changes how to organize finances. I was fiercely independent, and I didn’t have faith I could care for anyone else. But Antoinette always believed in me, and, somehow, every time I struggled with moving forward in our relationship, and every time I struggled with moving forward in life, Antoinette pushed me, and together we got through.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JddSpp">
“Fill in the blank,” the Drew Carey-looking cruise director said to me. “The ugliest thing about my wife is ____.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CxSwsI">
“Her tones,” I said, straight-faced. The host froze up, devoid of one-liners. We won, obviously.
</p>
<hr class="p-entry-hr" id="NcatkG"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wFKEWk">
Antoinette and I met in April 2009, after the lead organizer of the mentoring program I volunteered for asked me to pick up the new mentor, a Brooklynite studying Africana studies and communications at SUNY Albany, speeding toward her bachelor’s in three years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="co758N">
We cruised through the city in my blue Saturn as I fumbled over icebreakers: Where’re you from? What’re you studying?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w2Oe8c">
Luckily for me, Antoinette was more skilled at the conversation thing. She dug through my CDs, pointing out that she also loved Maxwell and Amy Winehouse.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="onBwD4">
From then on, every week we drove around discussing race and religion and swapping book recommendations. I learned that, right before we met, Antoinette had left her ex-fiancé. To mark a new beginning, she pierced her nose and went in for the big chop, cutting off any chemically treated hair, and rocked an afro puff. I adored her positive energy, so when she mentioned she wanted to get her driver’s license, I volunteered my car for practice.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LyEaOM">
We spent afternoons circling parking lots and gently bumping cars while parallel parking. When she scored her license, I came up with more excuses to hang out. After six months of being friends, she dropped the bomb, asking me via text: “Do you like me?” My hands shaking, I typed “yes.”
</p>
<div class="c-float-right">
<aside id="Yliraw">
<q>I knew a life with Antoinette was what was best for me. I just feared it wasn’t best for her.</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2sFfrY">
Soon, I introduced her to my small, close-knit Ashkenazi Jewish family, and she welcomed me into her large but distant Nigerian and Jamaican crew. I loved how close she was to her mom, how she planned to have an intergenerational household. She appreciated how I was best friends/nearly twins with my little sister, how my big sister and her husband set my #couplegoals. Together we cooked salt fish latkes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g2QAKz">
When Antoinette and I met, I was 28 and three years sober. I had spent most of my early 20s dropping in and out of college, spending time behind the locked double doors of St. Peter’s Hospital detox unit, failing out of their rehab. In the first few years of my sobriety, I spent my days chilling on the stoop outside 12-step meetings on the corner of Lexington, working an entry-level respite position at a local social work agency.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sTdnu1">
I liked my life in early recovery. I liked the room I rented in a two-bedroom on Morris St. Liked making meetings whenever I wanted. Liked volunteering to make myself feel good. My life felt safe. But four years after we started dating, Antoinette was tired of my inertia. She wanted marriage, a house, and a family (with seven kids, she used to joke).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RoVk8i">
As terrified of change as I was, I feared losing her more. I stalled for another year, but I finally popped the question over a bucket of seafood in a booth at our favorite Times Square eatery, Bubba Gump’s.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M8EUKv">
Then I talked her into delaying the ceremony another year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BfM8cH">
I knew I loved and adored her, but I didn’t have faith in myself. I had never envisioned a future for me that involved anything more than hitting up meetings and remaining stagnant at the same social work agency. Starting a family felt unfathomable. During my hazy years, I stopped attempting to get sober because I figured I would just relapse. Once sober, I wouldn’t push myself to take any additional risks — whether it be a better job or a marriage — expecting that I’d mess everything up. Proposing was terrifying, but, beneath my distress, I knew a life with Antoinette was what was best for me. I just feared it wasn’t best for her.
</p>
<hr class="p-entry-hr" id="smmRIx"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GKnyH7">
I remember reading a study that said <a href="https://www.theatlantic.com/health/archive/2014/10/the-divorce-proof-marriage/381401/">the more you spend on your wedding, the more likely it will end in divorce</a>. Every time Antoinette brought up ideas for venues, my mind spiraled. Neither of us made tons of money and neither was great at saving. To me, spending excessively on a wedding made no sense, but to Antoinette, money could always be made and was to be enjoyed. The tradition meant a lot to her so she wanted the perfect wedding ceremony, but, in truth, it probably meant more to me. A wedding made things absolute. I would either succeed at being a good partner forever or destroy her life. The more we spent, the more I felt the pressure mounting. Still, I pushed myself to brave forward with whatever Antoinette wished for.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yxkmeI">
To afford the wedding, I focused on our day-to-day bills — rent, car insurance, internet, groceries — while Antoinette saved for the ceremony. We quickly put a deposit down on the fourth floor of the New York State Museum, claiming Antoinette’s dream location. The setting included a sick view of the Empire State Plaza and Capitol building. It was the perfect Albany landmark for a romance that bloomed across its streets.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ezhn0D">
The wedding was scheduled for a Sunday because we kinda-sorta kept Shabbat, and I used the odd day as leverage to haggle down prices. We locked in Mallozzi’s, one of the capital’s ritziest caterers, as well as DJ Trumastr, Albany’s hottest DJ, who prepped a setlist consisting of Paul Simon, Lynxxx, and Beres Hammond, representing our diverse backgrounds. The affair came out to $26,112.86.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YBGAQ0">
To be clear, we didn’t pay it all ourselves. Her dad handled the photographer and the balance for the venue, and her mom took care of the honeymoon and wedding dress, and she financed transportation for nearly her entire extended family (after the wedding, my parents gifted us a $10,000 check, to start our life together — that promptly went toward debt). The more our family invested in our stock, the more I panicked it would all go belly up.
</p>
<hr class="p-entry-hr" id="wMN0kw"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sTfV8L">
Four months before our scheduled wedding date, my fears of failure turned catastrophic as my family fell into disarray.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fupPLI">
Just weeks before my youngest sister’s wedding — which I already struggled with because it felt like our relationship was changing — my brother-in-law walked out on my older sister. He had been my role model, my biggest male influence. He gave me my first beer, taught me all his comedy routines. I told myself that if my big sister’s marriage went sour, my relationship with Antoinette would, too.
</p>
<div>
<aside id="CnnTQr">
<q>We posed for pictures, smiling before the carousel, but the emotions were staged</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HhU8mK">
I was unable to send the wedding invites. Every time I postponed, Antoinette grew more frustrated, to the point where we were sleeping in separate rooms. I broke up with her, three times, assuring myself she’d be better off without me, but she continued to talk me into staying. Two months before the ceremony, I dropped the invites into the mailbox, but the stabbing thoughts intensified. I had dreams of her happy with someone else, starting a family with a guy who wasn’t as mentally ill as I was. I had nightmares of us getting married, having kids, then me turning into my brother-in-law, leaving the family I loved to suffer the repercussions. A week before the ceremony, I broke up with her for the final time, promising myself I wouldn’t budge.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1W6PyI">
Tears dampening her face, Antoinette smooshed her cheek into mine and whispered, “Just be with me for one day. Not all the future. Just a day.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="erZiDv">
At that moment, I decided to stay. To give it my best shot, just for that day. I tried to tell myself that I wasn’t my family, that I wasn’t the person I used to be. I decided I didn’t like myself at that moment, but I wanted to get better. I wanted to be the best person I could be, and the best person I could be was beside Antoinette, supporting her and celebrating her and growing with her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gsOT3g">
The day of the wedding, Antoinette half-expected I wouldn’t show. Even though we did the I-dos, she despised me for what I put her through, and I was frustrated with her for not having empathy during my crash. We threw the greatest party most of our guests had ever been to — impressing even my Nigerian ambassador father-in-law — but every kiss was strained. We posed for pictures, smiling before the carousel, but the emotions were staged. When we cruised off on our <em>Newlywed Game</em>-knockoff honeymoon, we were barely speaking.
</p>
<hr class="p-entry-hr" id="SvEYur"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qcxTk2">
In the months that followed, we dedicated ourselves to couples therapy, determined to make our relationship work. We both realized that we struggled with communicating: Antoinette often shut down, while I turned overly emotional. We had to learn new ways to speak to each other. We focused on each other’s strengths, recognizing that we each brought something special to the table that the other lacked. I took responsibility for spiraling out of control, nearly ruining our wedding, and she worked to be empathetic to my anxiety. I realized how desperately I wanted her to attain her every dream and how blessed I was that she chose me to be her partner in achieving them; she believed in me, and I began to believe in me, too.
</p>
<div class="c-float-right">
<aside id="ZY4XEG">
<q>We weren’t trying to show off — we just wanted to feed friends and family yummy food and spin in circles of joy</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LRNCSY">
For over a year, Antoinette had been meeting with our rabbi, taking classes, attending shul, moving toward converting to Judaism. We had always planned to have a second, intimate religious wedding after she formally converted. And so six months after the first wedding, my wife dunked herself into the mikvah, a ritual bath, completing the process, and we held a small ceremony in our Albany temple, costing $2,618: enough to rent the social hall, hire a klezmer band, contract a videographer, borrow a chuppah, and buy a crap ton of lox, bagels, and kugel.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sQ38DW">
The first wedding, we were trying to impress people, but this second wedding, we weren’t trying to show off — we just wanted to feed friends and family yummy food and spin in circles of joy. We didn’t even send invites. Instead, we handed out flyers and plastered them online, keeping the ceremony open to anyone who wanted to join.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zZyVXa">
I took pride in planning and paying for the second ceremony myself. Though the event was much cheaper, I didn’t settle for anything. The food was on point. So were our outfits. It felt like victory that every dollar spent was my own — I was investing in our future.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S118m3">
Under the chuppah, I crunched the glass and we jumped the broom. When we leaped, we did it together. The community lifted us aloft in chairs, and, as we floated above the crowd, each grasping the napkin connecting us, I realized I could do it. I could handle life’s changes. I could grow. My wife had been with me when I was at my lowest. I knew I’d do the same for her. We’d survived one of our toughest hurdles, and I had faith we could get through more. I was ready. Ready to create a home, ready to start a family, with faith, with Antoinette.
</p></li>
<li><strong>“We’re expected to be human shields”: Teachers are unprotected — and scared</strong> -
<figure>
<img alt="Teachers For Gun Legislation March Towards Senator Cruz’s Office" src="https://cdn.vox-cdn.com/thumbor/TgM8zb2gZTI8CGzsGcVa2VVgCF8=/222x0:3779x2668/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70968212/1241021922.0.jpg"/>
<figcaption>
After a mass shooting at Robb Elementary School in Uvalde, Texas, teachers for gun control legislation marched to Sen. Ted Cruz’s office. | Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After another school shooting, teachers express fear over the threat of violence in their classrooms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E8xVn9">
The day after the mass shooting at Robb Elementary School in Uvalde, Texas, Elizabeth, a first grade teacher at a school across the state, looked down at the sidewalk to read what one of her students had scribbled in chalk at the entrance to their school: “If you have a gun, get out pleas.” The child’s message, innocent with its spelling error, was decorated with the drawing of a little white heart.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PpG9VB">
That day, Elizabeth<strong> </strong>started locking both doors in her classroom. She told her students not to congregate in the hallway, to stop coming in and out of the room all day long, and “if you have to go to the bathroom, go quick and be back ASAP.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7UvrxU">
“I don’t care how inconvenient it is,” she said. “If that fourth grade classroom’s door had been locked, the shooter would not have been able to get inside. I have to remember that.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ix2mk3">
Elizabeth, who asked to be referred to by her middle name because “it’s a highly politicized issue … especially in Texas, and I don’t want to put myself at risk,” did all this because she felt ultimately responsible for her students’ safety. “This is by no means normal and anything I want to be doing with my students, but I felt it was the reality of that day, and I did what felt the safest,” she said.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/P0TKKc-PcYv3t0t8UZp_oYEwDJ8=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23617180/first_grade_art.jpg"/>
<figcaption>
After a mass shooting at an elementary school in Uvalde, Texas, in May, one first grader wrote a message outside of her school: “If you have a gun, get out pleas.”
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PPJHWB">
Previous mass shootings, like the 2012 one at Sandy Hook Elementary in Newtown, Connecticut, that claimed 27 lives, haven’t pushed lawmakers to prevent future ones.<strong> </strong>The country remains awash with guns, and few new burdens have been placed on would-be gun owners to stop future massacres. Instead, the burden of keeping students safe has fallen on schools — and ultimately on teachers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lxyehF">
In lockdown drills, teachers are expected to train their students to hide, and, in some cases, to fight. Proposals from arming teachers to “hardening schools” underscore the message that keeping schools safe is ultimately the responsibility of schools themselves, and of the adults in them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cdu6UV">
“So many of our teachers come to the profession because they love working with children. They love what they do, so they’re already always thinking about how they can help their children. There’s less of a focus on the emotional and traumatic experiences they’re having,” Prerna Arora, a school psychologist and assistant professor of school psychology at Columbia’s Teachers College, told Vox. “We have to consider how trauma impacts a teacher and their ability to be present and be there for their students.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9dz56K">
And if the worst should happen, teachers are often the last line of defense. While police dithered outside, two teachers in Uvalde died while shielding their students from gunfire. Since their deaths, the two teachers, Eva Mireles and Irma Garcia, have been called <a href="https://www.youtube.com/watch?v=sHR4yG5YEMo">heroes</a> — a label that does not capture the complexity of what teachers are expected to do and be every day. They’re expected to be counselors, nurses, human shields, and more.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TEaRkw">
Arnulfo Reyes, a teacher who survived the shooting at Robb Elementary, explained how he went from preparing for a student award ceremony that morning to being shot twice by the gunman and witnessing all 11 of the students in his classroom die. “I tried my best with what I was told to do,” he said in an <a href="https://abcnews.go.com/GMA/News/cowards-teacher-survived-uvalde-shooting-slams-police-response/story?id=85219697&amp;cid=social_fb_2020&amp;fbclid=IwAR3E5kIRdB_DJlyxYZaQD7_5rmPukaSStklzZdN_-fFXMdC_rUQ38qwdzVw">interview</a>. “It all happened too fast. Training, no training, all kinds of training, nothing gets you ready for this.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oZMwHw">
“We have to consider what happens to teachers when part of their job is the expectation that they might have to hug their children under a desk during a mass shooting,” said Arora. “It’s a horrifying visual, the idea of having to shield your students to protect them from gunshots after watching the movie <em>Moana</em>,” Arora said. “This is the only job in the country where someone is basically expected to do this when it’s not part of their job description or what they’re trained for.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OviCUF">
In the days since the shooting, <a href="https://www.vanityfair.com/news/2022/05/fox-news-militarizing-schools-gun-control">commentators</a> and <a href="https://www.texastribune.org/2022/05/28/uvalde-shooting-school-doors/">Texas lawmakers</a> have offered countless thoughts on school shootings, none of which involve gun safety reform. Texas’s Lt. Gov. Dan Patrick and Sen. Ted Cruz suggested that officials “harden schools,” leaving one entrance in and one entrance out. Others <a href="https://twitter.com/abughazalehkat/status/1529573713976377348">have suggested</a> arming teachers, or training students to fight shooters, or making body armor available at schools for students and educators. Other ideas call for a more imposing physical landscape: taller fencing, tripwires, metal detectors.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uMZkhX">
Many of the ideas, like positioning “<a href="https://www.vox.com/2022/5/25/23140519/uvalde-school-shooting-nra-texas-good-guy-gun">good guys with guns</a>” or <a href="https://www.vox.com/2022/5/29/23145515/pro-gun-lawmakers-arm-teachers-violence">arming teachers</a>, have not worked in the past. But they underscore that lawmakers are likely to put the responsibility of keeping schools safe back onto schools and teachers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ivfbTI">
“As a former volunteer firefighter, I can tell you that many of these ideas to lock down schools create huge safety concerns,” Josh, a science teacher in Houston who asked that only his first name be used for fear of retaliation, told Vox. “They also don’t address the root causes of shootings, which is access to guns and mental health. We don’t have enough counselors in our school and there just isn’t enough money to actually invest in mental health services.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rmW0O6">
He added: “We teachers have come under attack for many things this year. They don’t trust us to put out the appropriate books for our students but they trust us to carry guns in schools?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="czyGGP">
Rachel Graves Hicks, a high school career and technical education teacher in a large suburban school district near Fort Worth, Texas, has already spent time that could have been spent teaching on preparing for shootings. She routinely practices safety drills with her high schoolers. She tells them to place big items of furniture at the door, get out of sight, and be as quiet as possible. And should the shooter breach the door, she instructs her students to hurl items at them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IUCPSi">
The burden could someday become too much. “The day my district determines that teachers are allowed to carry guns at school, I will no longer work in the classroom. Full stop. I am out,” she said. “We tell them to throw monitors and chairs, anything that could stop the shooter,” she said. “How is this not enough?”
</p></li>
<li><strong>The power and limits of using executive orders to protect abortion rights</strong> -
<figure>
<img alt="Abortion rights activists protest outside Justice Brett Kavanaugh’s home following SCOTUS opinion leak" src="https://cdn.vox-cdn.com/thumbor/Nl15FVB6-D6j8UyiQHuRIOiCHRY=/0x0:3804x2853/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70967063/1241188561.0.jpg"/>
<figcaption>
Activists who feel helpless to codify abortion rights could find hope in Biden’s executive orders. | Nathan Howard/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
President Biden is mulling over what he can do in response to a looming Supreme Court ruling overturning <em>Roe v. Wade</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BXY4XR">
As a decision looms in <a href="https://www.scotusblog.com/case-files/cases/dobbs-v-jackson-womens-health-organization/"><em>Dobbs v. Jackson Women’s Health Organization</em></a>, the landmark Supreme Court case that would effectively eliminate the constitutionally-protected right to a legal abortion, pressure on President Joe Biden to take action protecting that right is mounting — so much so that Biden directly addressed it on late-night TV this week, telling Jimmy Kimmel that, while he urged legislative action, the White House is also mulling executive orders protecting abortion access.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9lvTMn">
Post-<em>Dobbs</em> executive orders were on the table before Biden’s Wednesday appearance, although the White House has kept quiet about what those actions could look like. His interview with Kimmel was no different; after encouraging a legislative approach to enacting abortion rights protections, Biden told Kimmel, “I think what we’re going to have to do… There’s some executive orders I could employ, we believe — we’re looking at that right now.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eLeVtj">
On Tuesday, before Biden’s late-night appearance, Democratic senators including Chris van Hollen of Maryland and Elizabeth Warren of Massachusetts <a href="https://www.vanhollen.senate.gov/imo/media/doc/2022.06.07%20Letter%20to%20POTUS%20on%20Abortion%20EO.pdf">sent a letter</a> to Biden urging the administration to issue an order to develop a national, whole-of-government plan to protect the right to abortion, citing the administration’s previous willingness to take action on securing voting rights, combatting racism, and strengthening economic competition.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2iLvU5">
“Now is the time for equally bold action to protect the right to an abortion,” the letter reads, asserting that, “the dramatic escalation of attacks on abortion access — spearheaded by right-wing justices, lawmakers, and activists — demands comprehensive and creative strategies from every corner of the federal government.” The letter urges Biden to issue an executive order requiring the heads of federal agencies to submit their plans to protect abortion rights within 30 days of the order, concluding that the issue — and the millions who would be affected should the Supreme Court rule that Mississippi can indeed ban pre-viability abortions — require “no less than a whole-of-government response.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="olbopV">
However, the administration has signaled that any action will come after the court announces its decision — not pre-emptively. “We don’t have a final conclusion,” former White House Press Secretary Jen Psaki said at a briefing in May, after a draft decision authored by conservative Supreme Court Justice Samuel Alito declaring the Mississippi restriction constitutional was leaked to <a href="https://www.politico.com/news/2022/05/02/read-justice-alito-initial-abortion-opinion-overturn-roe-v-wade-pdf-00029504">Politico</a>. “The Supreme Court themselves made clear this is not the final opinion. We are already working a great deal behind the scenes, and we will have more to say,” <a href="https://thehill.com/news/administration/3479097-democrats-worry-they-lack-a-plan-to-fight-back-on-roe-v-wade/">Psaki said at the time</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1nb2w6">
While the administration <a href="https://thehill.com/news/administration/3517080-biden-says-he-is-weighing-executive-orders-on-abortion-rights/">reportedly ramped up</a> its planning after the draft memo leaked, holding meetings with providers, activists, and state lawmakers, Democrats and abortion rights activists have been frustrated with the perceived lack of preparation for what many consider the inevitable dissolution of <em>Roe v. Wade </em>after decades of conservative activism to defeat it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EiIDHy">
“Why are we so behind the curve on this? Where is the plan? We knew this was coming in theory since [Justice Amy] Coney Barrett joined the court, and in practice since December,” Democratic strategist Christy Setzer <a href="https://thehill.com/news/administration/3479097-democrats-worry-they-lack-a-plan-to-fight-back-on-roe-v-wade/">told The Hill</a> in May. “I don’t want to hear empty rhetoric about how we won’t go back, I want to hear that there is a legislative or federal plan to change things.”
</p>
<h3 id="INijyJ">
What exactly could executive orders do for abortion rights?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TIsuLQ">
At the heart of <a href="https://www.supremecourt.gov/DocketPDF/19/19-1392/145658/20200615170733513_FINAL%20Petition.pdf">the <em>Dobbs </em>case</a> are three questions: Whether it’s unconstitutional for a state to enact any pre-viability bans on abortion; under what statute any such prohibition should be interpreted; and whether abortion providers have the legal standing to challenge a state’s abortion laws on behalf of their patients.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KOJRG2">
Any executive action the administration decides on will be fairly limited; once states have the authority to regulate pre-viability abortion regardless of the undue burdens the laws would place on people trying to obtain them, <a href="https://www.nytimes.com/2022/05/04/us/abortion-trigger-laws.html">many will legislate it</a> <a href="https://reproductiverights.org/maps/what-if-roe-fell/">practically out of existence</a>. If it’s decided that abortion clinics don’t have legal standing to challenge laws those states enact, it’s unlikely they’ll be challenged at all, since such cases require significant resources that individual abortion patients likely don’t have.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v4Px74">
Any executive orders wouldn’t challenge the ruling directly, but rather enhance access to resources for people seeking an abortion. “As far as specific actions, there’s any number of areas of concern they could seek to address,” Setzer told Vox via email, such as “working to increase access for low-income women and women of color even in blue states like New York and Connecticut; protecting patient privacy (for patients and medical workers) where abortion will be criminalized; increasing access to contraception under Obamacare in states where it’s limited; working to lessen barriers to getting the abortion pill.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="44LgIp">
In their June 7 letter, Democratic legislators highlighted some actions Biden could take, like enabling greater access to medication abortion, a method of abortion that’s effective very early on in a pregnancy. The medications <a href="https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/mifeprex-mifepristone-information">mifepristone and misoprostol</a>, which, taken together, safely and effectively end early pregnancies have been available by mail <a href="https://www.nytimes.com/2021/12/16/health/abortion-pills-fda.html">since the FDA reversed a regulation</a> prohibiting the postal delivery last December. However, a number of states with conservative legislatures swiftly took action to ban or restrict access to them following that decision.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="im4Bcg">
The Democrats’ letter also suggests providing resources like childcare and travel vouchers to people who must travel outside their home state to seek abortion care. That measure would address what is already a barrier for low-income people seeking an abortion: the sheer cost of it all, in addition to the price of the procedure itself. Childcare, travel expenses, and lost wages from missing work are all costs that low-income people seeking abortions in states with limited access have faced for years, <a href="https://theintercept.com/2019/01/18/abortion-roe-v-wade-reproductive-rights/">as The Intercept reported in 2019.</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="87ME73">
The letter suggests a few interventions from the Department of Health and Human Services (HHS), including creating a reproductive health ombudsman position which “could educate the public and analyze data collected by HHS about access to reproductive services.” That could include collecting and analyzing data about insurance coverage for contraception, as well as provide information about access to abortion services and funding. The legislators also suggest HHS work to expand the pool of reproductive health providers available to Medicaid patients by “more aggressively enforcing federal requirements” that give beneficiaries their choice of provider.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RoHlpe">
HHS’s Office of Civil Rights could also strengthen and clarify protection of people’s sensitive online data about their reproductive health so that data can’t be used by states with draconian abortion and reproductive health laws. Data protection is crucial for both people seeking abortions and for care providers; data from a period tracking app, for example, could prevent a person from getting an abortion because it could indicate how far along their pregnancy is, and sensitive information about abortion providers could endanger their freedom or safety.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M660No">
Finally, a mobilization of federal resources — including providing reproductive health care on federal lands in states with severe abortion restrictions — could be on the table, too. The legislators suggest in the June 7 letter that the Pentagon could consider moving members of the military and their families to obtain abortion and reproductive health care when they need it, and that the Office of Personnel Management could ensure paid time off and reimbursement of costs for the procedure for federal employees who get an abortion.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FlnUH9">
All of these suggestions are workarounds; they’re not really a direct challenge to the issues presented in the <em>Dobbs </em>case. But, given how intent the GOP is on steamrolling the right to an abortion, and the dwindling likelihood of a Democratic majority passing legislation to protect it, such measures may just be what the administration has to work with.
</p>
<h3 id="R5m7iZ">
Legislative protections would be more secure — but they’re harder to enact
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DvHKmq">
Biden pushed the importance of voting and legislative action during his appearance on Wednesday, claiming that if <em>Dobbs</em> is decided and trigger laws go into effect, “it’s going to cause a mini revolution and they’re going to vote a lot of these folks out of office.” But in general, <a href="https://pprg.stanford.edu/wp-content/uploads/2008-Turnout-Lit-Review.pdf">people don’t just vote on one issue</a>, and simply relying on outrage isn’t a great game plan; decades without a clear strategy and concrete ideas about how to protect abortion access has put Democrats and reproductive health care in this position in the first place.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IGb8us">
“Part of my frustration is with, frankly, some of my own colleagues and peers. The other side for 50 years has had a legal strategy — where is our 50-year strategy?” Rep. Elisa Slotkin (D-MI) <a href="https://www.politico.com/news/2022/06/09/biden-abortion-00038565">said Thursday</a>. “As someone who comes from a CIA and Pentagon background, I’m frankly furious that there wasn’t more D-Day, decision day, planning.”
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Biden, as the leader of the party, hasn’t been particularly forceful in making sure abortion rights are protected, either. “In general, this is an issue where the bully pulpit really matters, and where President Biden still seems afraid to even say the word ‘abortion,’” Setzer told Vox. “That’s the point — the first step to protecting abortion access is saying the words ‘abortion access.’”
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Without full-throated support for abortion at the highest levels, passing legislation to protect abortion rights is a tough hill to climb. It has failed in the past; last year, the <a href="https://www.congress.gov/bill/117th-congress/house-bill/3755/text">Women’s Health Protection Act</a> passed in the <a href="https://rollcall.com/2021/09/24/house-passes-abortion-rights-legislation/">House without a single Republican vote</a>. It failed in the Senate in May, even after the leaked <em>Dobbs </em>draft, given that it had no Republican support and West Virginia Sen. Joe Manchin, a <a href="https://justfacts.votesmart.org/candidate/political-courage-test/7547/joe-manchin-iii">self-styled anti-abortion Democrat</a>, voted against it, too. Expecting fear and outrage over one single issue to change the face of state legislatures, much less the Senate, seems like wishful thinking, particularly if the president doesn’t seem to proactively pursue both options to protect abortion access and alternatives to conservative rule.
</p>
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Instead of Biden’s and Democrats’ milquetoast response, Setzer said, Biden and Democtrats should be talking about abortion “every chance they get. Congress voted on the Women’s Health Protection Act— super. Now make Republicans vote on abortion 20 more times before November. Make them go on record again and again. Use it in ads. Don’t be afraid — this is a winning political issue.”
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Without an aggressive response, the idea that the <em>Dobbs </em>decision alone could and will make a difference in the midterms isn’t at all convincing. “President Biden’s not wrong — overturning Roe could indeed galvanize votes for Democrats in the midterms, but only if we can believe that the White House can and will take up that fight, and it’s not a promising start,” Setzer said. “I’m frankly not swayed by their secret plan on abortion.”
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Grand double for Rajini Krishnan</strong> - Pacer Yamaha boys steal the show</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Running individual 400m is not yet over for Hima, hints at doing that again in postponed Asian Games</strong> - The 22-year-old ‘Dhing Express’ last ran a major 400m race during the Asian Championships in Doha in April 2019.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watch | School girl from Sri Lanka’s north breaks cricketing barriers</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sreeshankar sets sights on Worlds, Commonwealth Games</strong> - Long jump National record-holder looks to work on his consistency</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Another DK returns from commentary box to set the field ablaze</strong> - Dhawal Kulkarni was instrumental in Mumbai’s record win over Uttarakhand in the Ranji quarterfinal</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Development of villages must to achieve goal of making India $5 trillion economy: Amit Shah</strong> - “Mahatma Gandhi had said the soul of the country is in our villages and I firmly believe that,” said Union minister Amit Shah</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AIADMK is the main Opposition party in and outside Assembly, says Panneerselvam</strong> - ‘TV news channel debates try to make out that AIADMK is lax in its role’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AIADMK district secretaries to meet on June 14</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Akhilesh shares video of cops thrashing men in ‘lock-up’, raises question over incident</strong> - “Questions must be raised on such a detention.”</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ED's summons to Rahul ‘baseless’, says Chidambaram</strong> - Congress leaders in states will also take out marches to the agency offices in their respective States and will stage “satyagraha” on Monday.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Chemical plant hit as fighting rages in Severodonetsk</strong> - Russian shelling causes a huge fire at the Azot plant in Severodonetsk, a Ukrainian official says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia unveils ‘tasty’ McDonald’s substitute</strong> - The fast food outlets are rebranded as “Tasty and that’s it” after the burger giant pulled out.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia hands out passports in occupied Ukraine cities</strong> - The issuing of Russian passports in occupied Kherson and Melitopol is condemned by Kyiv.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>German ex-footballer condemns Qatar over gay rights</strong> - Oliver Bierhoff says the World Cup host’s treatment of gay people is “absolutely unacceptable”.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Border rapist trial starts in France for 56 attacks</strong> - Dino Scala is accused of a 30-year series of rapes and sexual assaults.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why can’t we remember being born or our first words?</strong> - What scientists know about “infantile amnesia.” - <a href="https://arstechnica.com/?p=1860244">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NASA’s plan to get Ingenuity through the Martian winter</strong> - NASA engineers are trying to overcome colder nights and frequent dust storms. - <a href="https://arstechnica.com/?p=1860133">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The weekend’s best deals: Apple Music subscriptions, Sony headphones, and more</strong> - Dealmaster also includes Sonos speakers, lots of video games, and the Google Chromecast. - <a href="https://arstechnica.com/?p=1860239">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mutations thought to be harmless turn out to cause problems</strong> - Mutations in genes that don’t alter proteins can still alter survival in yeast. - <a href="https://arstechnica.com/?p=1860267">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Frost Giant Studios’ debut mixes Starcraft with Diablo</strong> - New studio’s first foray is a RTS game that focuses on fun and ’90s vibes. - <a href="https://arstechnica.com/?p=1860160">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Finally, a blonde joke I haven’t heard before…</strong> - <!-- SC_OFF -->
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A blonde gets a job as a physical education teacher of 16-year-olds.
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She notices a boy at the end of the field standing alone, while<br/> all the other kids are running around having fun kicking a ball.
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She takes pity on him and decides to speak to him.
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‘You ok?’ she says.
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‘Yes.’ he says.
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‘You can go and play with the other kids you know’ she says.
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‘It’s best I stay here.’ he says.
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‘Why’s that sweetie?’ says the blonde.
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The boy looks at her incredulously and says,
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“Because I’m the Goalie!”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/jmancoder2008"> /u/jmancoder2008 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vaa024/finally_a_blonde_joke_i_havent_heard_before/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vaa024/finally_a_blonde_joke_i_havent_heard_before/">[comments]</a></span></p></li>
<li><strong>A rude man walks into the bank and tells the teller: “I want to open a fucking checking account.” [NSFW]</strong> - <!-- SC_OFF -->
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A rude man walks into the bank and tells the teller: “I want to open a fucking checking account.”
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The teller, upset, says “We don’t tolerate language like that here.”
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The man asks “What’s the fucking problem? It’s not like anyone really gives a shit!”
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The teller then leaves without a word, to go and speak to the manager about how to deal with this man. The manager, hearing the story, goes back to the man to see what the problem is.
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After asking the man, he responds with " There is no fucking problem. All I wanna do is cash my 10 million dollar check from winning the lottery and then put it in this goddamn bank!"
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The manager responds with “Oh, and is this bitch over here giving you any problems, sir?”
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/B-L-O-C-K-S"> /u/B-L-O-C-K-S </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v9zt46/a_rude_man_walks_into_the_bank_and_tells_the/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v9zt46/a_rude_man_walks_into_the_bank_and_tells_the/">[comments]</a></span></p></li>
<li><strong>I won $1M in the lottery</strong> - <!-- SC_OFF -->
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I gave a quarter of it to charity, and put the other $999,999.75 in the bank.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/punchCuddles"> /u/punchCuddles </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/va86pa/i_won_1m_in_the_lottery/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/va86pa/i_won_1m_in_the_lottery/">[comments]</a></span></p></li>
<li><strong>My girlfriend once caught me masturbating to an optical illusion.</strong> - <!-- SC_OFF -->
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I told her “it’s not what it looks like”.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/the-fire-in-flame"> /u/the-fire-in-flame </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v9v3mh/my_girlfriend_once_caught_me_masturbating_to_an/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v9v3mh/my_girlfriend_once_caught_me_masturbating_to_an/">[comments]</a></span></p></li>
<li><strong>Ebola, covid, and monkeypox walk into a bar.</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The bartender says, “What is this, some kinda sick joke?”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/cantab314"> /u/cantab314 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vaasoo/ebola_covid_and_monkeypox_walk_into_a_bar/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vaasoo/ebola_covid_and_monkeypox_walk_into_a_bar/">[comments]</a></span></p></li>
</ul>
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