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<title>13 April, 2021</title>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Compliance with Covid-19 measures: evidence from New Zealand</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Governments around the world are seeking to slow the spread of Covid-19 by implementing measures that encourage, or mandate, changes in people9s behaviour. These changes include the wearing of face masks, social distancing, and testing and self-isolating when unwell. The success of these measures depends on the commitment of individuals to change their behaviour accordingly. Understanding and predicting the motivation of individuals to change their behaviour is therefore critical in assessing the likely effectiveness of these measures in slowing the spread of the virus. In this paper we draw on a novel framework, the I3 Compliance Response Framework, to understand and predict the motivation of residents in Auckland, New Zealand, to comply with measures to prevent the spread of Covid-19. The Framework is based on two concepts. The first uses the involvement construct to predict the motivation of individuals to comply. The second separates the influence of the policy measure from the influence of the policy outcome on the motivation of individuals to comply. The Framework differentiates between the strength of individuals9 motivation and their beliefs about the advantages and disadvantages of policy outcomes and policy measures. We show this differentiation is useful in predicting an individual9s possible behavioural responses to a measure and how it assists government agencies to develop strategies to enhance compliance.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.08.21255157v1" target="_blank">Compliance with Covid-19 measures: evidence from New Zealand</a>
</div></li>
<li><strong>Refining long-COVID by a prospective multimodal evaluation of patients with long-term symptoms related to SARS-CoV-2 infection</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: COVID-19 long-haulers or long-COVID represent 10% of COVID-19 patients and remain understudied. Methods: In this prospective study, we recruited 30 consecutive patients seeking medical help for persistent symptoms (&gt; 30 days) attributed to COVID-19. All reported a viral illness compatible with COVID-19. The patients underwent a multi-modal evaluation including clinical, psychological, virological, specific immunological assays and were followed longitudinally. Results The median age was 40 [interquartile range: 35-54] and 18 (60%) were female. After a median time of 152 [102-164] days after symptom onset, fever, cough and dyspnea were less frequently reported as compared with the initial presentation, but paresthesia and burning pain emerged in 18 (60%) and 13 (43%) patients, respectively. The clinical examination was unremarkable in all patients although the median fatigue and pain visual analogic scales were 7 [5-8] and 5 [2-6], respectively. Extensive biological studies were unremarkable, as were multiplex cytokine and ultra-sensitive interferon-a2 measurements. At this time, nasopharyngeal swab and stool RT-PCR were negative for all tested patients. Using SARS-CoV-2 serology and IFN-γ ELISPOT, we found evidence of a previous SARS-CoV-2 infection in 50% (15/30) of patients, with objective evidence of lack or waning of immune response in two. Finally, psychiatric evaluation showed that 11 (36.7%), 13 (43.3%) and 9 (30%) patients had a positive screening for anxiety, depression and post-traumatic stress disorder, respectively. Conclusions Half of patients seeking medical help for long-COVID lack SARS-CoV-2 immunity. The presence of SARS-CoV-2 immunity did not cluster clinically or biologically long haulers, who reported severe fatigue, altered quality of life, and exhibited psychological distress.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.08.21255167v1" target="_blank">Refining long-COVID by a prospective multimodal evaluation of patients with long-term symptoms related to SARS-CoV-2 infection</a>
</div></li>
<li><strong>COLI-NET: Fully Automated COVID-19 Lung and Infection Pneumonia Lesion Detection and Segmentation from Chest CT Images</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background We present a deep learning (DL)-based automated whole lung and COVID-19 pneumonia infectious lesions (COLI-Net) detection and segmentation from chest CT images. Methods We prepared 2358 ( 347259, 2D slices) and 180 (17341, 2D slices) volumetric CT images along with their corresponding manual segmentation of lungs and lesions, respectively, in the framework of a multi-center/multi-scanner study. All images were cropped, resized and the intensity values clipped and normalized. A residual network (ResNet) with non-square Dice loss function built upon TensorFlow was employed. The accuracy of lung and COVID-19 lesions segmentation was evaluated on an external RT-PCR positive COVID-19 dataset (7333, 2D slices) collected at five different centers. To evaluate the segmentation performance, we calculated different quantitative metrics, including radiomic features. Results The mean Dice coefficients were 0.98&amp;0.011 (95% CI, 0.98-0.99) and 0.91&amp;0.038 (95% CI, 0.90-0.91) for lung and lesions segmentation, respectively. The mean relative Hounsfield unit differences were 0.03&amp;0.84% (95% CI, -0.12-0.18) and -0.18&amp;3.4% (95% CI, -0.8 - 0.44) for the lung and lesions, respectively. The relative volume difference for lung and lesions were 0.38&amp;1.2% (95% CI, 0.16-0.59) and 0.81&amp;6.6% (95% CI, -0.39-2), respectively. Most radiomic features had a mean relative error less than 5% with the highest mean relative error achieved for the lung for the Range first-order feature (-6.95%) and least axis length shape feature (8.68%) for lesions. Conclusion We set out to develop an automated deep learning-guided three-dimensional whole lung and infected regions segmentation in COVID-19 patients in order to develop fast, consistent, robust and human error immune framework for lung and pneumonia lesion detection and quantification. Keywords: X-ray CT, COVID-19, pneumonia, deep learning, segmentation.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.08.21255163v1" target="_blank">COLI-NET: Fully Automated COVID-19 Lung and Infection Pneumonia Lesion Detection and Segmentation from Chest CT Images</a>
</div></li>
<li><strong>Social norms, social identities and the COVID-19 pandemic: Theory and recommendations</strong> -
<div>
Sustained mass behaviour change is needed to tackle the COVID-19 pandemic, but many of the required changes run contrary to existing social norms (e.g., physical closeness with ingroup members). This paper explains how social norms and social identities are critical to explaining and changing public behaviour. Recommendations are presented for how to harness these social processes to maximise adherence to COVID-19 public health guidance. Specifically, we recommend that public health messages clearly define who the target group is, are framed as identity-affirming rather than identity-contradictory, include complementary injunctive and descriptive social norm information, are delivered by ingroup members and that support is provided to enable the public to perform the requested behaviours.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/m9afs/" target="_blank">Social norms, social identities and the COVID-19 pandemic: Theory and recommendations</a>
</div></li>
<li><strong>Big Five traits, approach-avoidance motivation, concerns and adherence with COVID-19 prevention guidelines during peak of pandemics in Croatia</strong> -
<div>
Without the vaccine, the only way to prevent the spread of coronavirus is following Covid-19 preventive guidelines such as keeping social distance, wearing masks and gloves, reducing mobility, etc. Success depends on how many individuals strictly follow the suggestions from epidemiologists. In this study, we examined who and why is adhering to the guidelines. A community sample of 500 participants fulfilled a short Big Five Inventory (BFI), Questionnaire of Approach and Avoidance Motivation (QAAM), and two scales constructed according to the Covid-19 epidemiological guidelines in Croatia. The results of the hierarchical regression analysis indicate that agreeable and conscientious individuals are complying more with preventive measures. In addition, approach, not avoidance, motivation appears to be more important in following the guidelines. Results are discussed in terms of framing messages to explain goals that might be reached by compliant behaviour rather than emphasising the negative consequences of the pandemic. Emphasising negative consequences seems to produce negative emotional states with no beneficial changes on the behavioural level.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/3edyb/" target="_blank">Big Five traits, approach-avoidance motivation, concerns and adherence with COVID-19 prevention guidelines during peak of pandemics in Croatia</a>
</div></li>
<li><strong>Efficacy of Pranayama in Preventing COVID-19 in Exposed Healthcare Professionals: A Randomized Controlled Trial</strong> -
<div>
Background: The global outbreak of COVID-19 has created a challenging situation, especially among the frontline Health Care Professionals (HCPs), who are routinely exposed and thus at a relatively higher risk of infection. A few studies have shown the practice of Pranayama, a component of Yoga, to be effective in improving immune function and reducing infection. However, no clinical trial on the efficacy of Pranayama in preventing COVID-19 has been conducted. Aim &amp; Objective: This randomized clinical trial assessed the effect of Pranayama in preventing COVID-19 infection in Health Care Professionals (HCPs) routinely exposed to COVID-19 cases. Methodology: The study was conducted at 5 different COVID-19 hospitals in New Delhi, India during September-November, 2020. 280 HCPs assigned duties with COVID-19 patients who were found negative in COVID-19 antibody test in pre-intervention assessment were recruited and randomly assigned to intervention and control groups. The intervention group practiced especially designed Pranayama modules twice a day (morning and evening) for 28 days under the supervision of Yoga instructors through online mode, while those in the control group were advised general fitness practices (like walking, jogging, running). Participants who became symptomatic underwent RTPCR / Point of Care Rapid Antigen test for confirmation of COVID 19 diagnosis. All the patients also underwent antibody testing for COVID-19 on 28th day of the intervention to detect asymptomatic infection. Results: 250 participants, comprising 123 in the intervention group and 127 in the control group, completed the study . The intervention and control groups had comparable demographics and baseline characteristics. Three participants (all controls) developed COVID 19 symptoms during the study. On the completion of the study, only one participant in the Intervention group tested positive, while 9 participants in the control group (Including three symptomatic participants) tested positive for COVID-19 antibodies. This difference was statistically significant (P-value: 0.01). Conclusion: Practice of our especially designed Pranayama module, every day for 28 days was highly effective in preventing COVID-19 infection in exposed healthcare professionals (HCPs).
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/c3qub/" target="_blank">Efficacy of Pranayama in Preventing COVID-19 in Exposed Healthcare Professionals: A Randomized Controlled Trial</a>
</div></li>
<li><strong>LRR protein RNH1 inhibits inflammasome activation through proteasome-mediated degradation of Caspase-1 and is associated with adverse clinical outcomes in COVID-19 patients.</strong> -
<div>
Inflammasomes are cytosolic innate immune sensors that, upon activation, induce caspase-1 mediated inflammation. Although inflammation is protective, uncontrolled excessive inflammation can cause inflammatory diseases and is also detrimental in COVID-19 infection. However, the underlying mechanisms that control inflammasome activation are incompletely understood. Here we report that the leucine rich repeat (LRR) protein Ribonuclease inhibitor (RNH1), which shares homology with LRRs of NOD-like receptor family pyrin domain (PYD)-containing (NLRP) proteins, attenuates inflammasome activation. Mechanistically, RNH1 decreased pro-IL1b expression and induced proteasome-mediated caspase-1 degradation. Corroborating this, mouse models of monosodium urate (MSU)-induced peritonitis and LPS-induced endotoxemia, which are dependent on caspase-1, respectively showed increased neutrophil infiltration and lethality in Rnh1-/- mice compared to WT mice. Further, RNH1 protein levels were negatively correlated with inflammation and disease severity in hospitalized COVID-19 patients. We propose that RNH1 is a new inflammasome regulator with relevance to COVID-19 severity.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.12.438219v1" target="_blank">LRR protein RNH1 inhibits inflammasome activation through proteasome-mediated degradation of Caspase-1 and is associated with adverse clinical outcomes in COVID-19 patients.</a>
</div></li>
<li><strong>Epitope profiling of coronavirus-binding antibodies using computational structural modelling</strong> -
<div>
Identifying the epitope of an antibody is a key step in understanding its function and its potential as a therapeutic. It is well-established in the literature that sequence-based clonal clustering can identify antibodies with similar epitope complementarity. However, there is growing evidence that antibodies from markedly different lineages but with similar structures can engage the same epitope with near-identical binding modes. Here, we describe a novel computational method for epitope profiling based on structural modelling and clustering, and show how it can identify sequence-dissimilar antibodies that engage the same epitope. We start by searching for evidence of structural conservation across the latest solved SARS-CoV-2-binding antibody crystal structures. Despite the relatively small number of solved structures, we find numerous examples of sequence-diverse but structurally-similar coronavirus-binding antibodies engaging the same epitope. We therefore developed a high-throughput structural modeling and clustering method to identify functionally-similar antibodies across the set of thousands of coronavirus-binding antibody sequences in the Coronavirus Antibody Database (CoV-AbDab). In the resulting multiple-occupancy structural clusters, 92% bind to consistent domains based on CoV-AbDab metadata. Our approach functionally links antibodies with distinct genetic lineages, species origins, and coronavirus specificities. This indicates greater convergence exists in the immune responses to coronaviruses than would be suggested by sequence-based approaches. Our results show that applying structural analytics to large class-specific antibody databases will enable high confidence structure-function relationships to be drawn, yielding new opportunities to identify functional convergence hitherto missed by sequence-only analysis.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.12.439478v1" target="_blank">Epitope profiling of coronavirus-binding antibodies using computational structural modelling</a>
</div></li>
<li><strong>Interactions between SARS-CoV-2 N-protein and α-synuclein accelerate amyloid formation</strong> -
<div>
First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson’s disease have been reported. Currently it is unclear if there also is a direct causal link between these diseases. To obtain first insights into a possible molecular relation between viral infections and the aggregation of -synuclein protein into amyloid fibrils characteristic for Parkinson’s disease, we investigated the effect of the presence of SARS-CoV-2 proteins on synuclein aggregation. We show, in test tube experiments, that SARS-CoV-2 S-protein has no effect on -synuclein aggregation while SARS-CoV-2 N-protein considerably speeds up the aggregation process. We observe the formation of multi-protein complexes, and eventually amyloid fibrils. Microinjection of N-protein in SHSY-5Y cells disturbed the -synuclein proteostasis and increased cell death. Our results point toward direct interactions between the N-protein of SARS-CoV-2 and -synuclein as molecular basis for the observed coincidence between SARS-CoV-2 infections and Parkinsonism.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.12.439549v1" target="_blank">Interactions between SARS-CoV-2 N-protein and α-synuclein accelerate amyloid formation</a>
</div></li>
<li><strong>Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by the broad-spectrum anti-infective drug nitazoxanide</strong> -
<div>
The emergence of the highly-pathogenic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease-2019), has caused an unprecedented global health crisis, as well as societal and economic disruption. The SARS-CoV-2 spike (S), a surface-anchored trimeric class-I fusion glycoprotein essential for entry into host cells, represents a key target for developing vaccines and therapeutics capable of blocking virus invasion. The emergence of several SARS-CoV-2 spike variants that facilitate virus spread and may affect the efficacy of recently developed vaccines, creates great concern and highlights the importance of identifying antiviral drugs to reduce SARS-CoV-2-related morbidity and mortality. Nitazoxanide, a thiazolide originally developed as an antiprotozoal agent with recognized broad-spectrum antiviral activity in-vitro and in clinical studies, was recently shown to be effective against several coronaviruses, including SARS-CoV-2. Using biochemical and pseudovirus entry assays, we now demonstrate that nitazoxanide interferes with the SARS-CoV-2 spike biogenesis, hampering its maturation at an endoglycosidase H-sensitive stage, and hindering its fusion activity in human cells. Besides membrane fusion during virus entry, SARS-CoV-2 S-proteins in infected cells can also trigger receptor-dependent formation of syncytia, observed in-vitro and in COVID-19 patients tissues, facilitating viral dissemination between cells and possibly promoting immune evasion. Utilizing two different quantitative cell-cell fusion assays, we show that nitazoxanide is effective in inhibiting syncytia formation mediated by different SARS-CoV-2 spike variants in human lung, liver and intestinal cells. The results suggest that nitazoxanide may represent a useful tool in the fight against COVID-19 infections, inhibiting SARS-CoV-2 replication and preventing spike-mediated syncytia formation.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.12.439201v1" target="_blank">Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by the broad-spectrum anti-infective drug nitazoxanide</a>
</div></li>
<li><strong>Undergraduate student interest in healthcare career in the context of COVID-19 pandemic</strong> -
<div>
Objectives: The healthcare profession has been long considered an excellent career choice. Pre-medical experience is documented to be important in shaping future medical landscape. In the wake of the pandemic, there has been intense media spotlight on the healthcare profession and change in academic environment, necessitating analyses of student experience. This project aims to assess change in undergraduate student interest in healthcare career using cross-sectional survey study. Methods: The project was approved by our Institutional Review Board. Voluntary survey collected data on demographics, socioeconomics, media exposure, academic environment, and change in interest in a healthcare profession. Survey was distributed through the university undergraduate pre-health listserv. Total of 297 responses were obtained. Descriptive statistics including Fisher exact test were applied in the analysis. Results: Majority of the respondents were Asians (54.9%), second generation immigrants (52.2%), and female (73.4%). Large proportion of the respondents were negatively affected by the pandemic, with losing a job or internship personally (42.1%) or a family member or a friend (62.6%). Students had mixed response to online learning environment, with 27.3% of students noting no change, 40.4% students noting increased difficulty, and 32.3% students noting decreased difficulty of classes. During the pandemic, 47.5% of students noted increased interest in pursuing healthcare career. The change in interest in healthcare career was not associated with demographics, economic hardship, or online learning environment. Discussion: Despite the challenges of COVID-19 pandemic, students showed strong interest in pursuing healthcare careers.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.11.438530v1" target="_blank">Undergraduate student interest in healthcare career in the context of COVID-19 pandemic</a>
</div></li>
<li><strong>RESIC: A tool for comprehensive adenosine to inosine RNA Editing Site Identification and Classification</strong> -
<div>
Adenosine to inosine (A-to-I) RNA editing, the most prevalent type of RNA editing in metazoans, is carried out by adenosine deaminases (ADARs) in double-stranded RNA regions. Several computational approaches have been recently developed to identify A-to-I RNA editing sites from sequencing data, each addressing a particular issue. Here we present RESIC, an efficient pipeline that combines several approaches for the detection and classification of RNA editing sites. The pipeline can be used for all organisms and can use any number of RNA-sequencing datasets as input. RESIC provides 1. The detection of editing sites in both repetitive and non-repetitive genomic regions; 2. The identification of hyper-edited regions; 3. Optional exclusion of polymorphism sites to increase reliability, based on DNA, and ADAR-mutant RNA sequencing datasets, or SNP databases. We demonstrate the utility of RESIC by applying it to human, successfully overlapping and extending the list of known putative editing sites. We further tested changes in the patterns of A-to-I RNA editing, and RNA abundance of ADAR enzymes, following SARS-CoV-2 infection in human cell lines. Our results suggest that upon SARS-CoV-2 infection, compared to mock, the number of hyper editing sites is increased, and in agreement, the activity of ADAR1, which catalyzes hyper-editing, is enhanced. These results imply the involvement of A-to-I RNA editing in conceiving the unpredicted phenotype of COVID-19 disease. RESIC code is open-source and is easily extendable.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.11.439401v1" target="_blank">RESIC: A tool for comprehensive adenosine to inosine RNA Editing Site Identification and Classification</a>
</div></li>
<li><strong>Expression of the ACE2 virus entry protein in the nervus terminalis suggests an alternative route for brain infection in COVID-19</strong> -
<div>
Previous studies suggested that the SARS-CoV-2 virus may gain access to the brain by using a route along the olfactory nerve. However, there is a general consensus that the obligatory virus entry receptor, angiotensin converting enzyme 2 (ACE2), is not expressed in olfactory receptor neurons, and the timing of arrival of the virus in brain targets is inconsistent with a neuronal transfer along olfactory projections. We determined whether nervus terminalis neurons and their peripheral and central projections may provide an alternative route from the nose to the brain. Nervus terminalis neurons were double-labeled with antibodies against ACE2 and nervus terminalis markers in postnatal mice. We show that most nervus terminalis neurons with cell bodies in the region between the olfactory epithelium and the olfactory bulb express ACE2, and therefore may provide a direct route for the virus from the nasal epithelium and Bowman glands to brain targets, including the telencephalon and diencephalon.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.11.439398v1" target="_blank">Expression of the ACE2 virus entry protein in the nervus terminalis suggests an alternative route for brain infection in COVID-19</a>
</div></li>
<li><strong>An AI-guided invariant signature places MIS-C with Kawasaki disease in a continuum of host immune responses</strong> -
<div>
A significant surge in cases of multisystem inflammatory syndrome in children (MIS-C, also called Pediatric Inflammatory Multisystem Syndrome - PIMS) has been observed amidst the COVID-19 pandemic. MIS-C shares many clinical features with Kawasaki disease (KD), although clinical course and outcomes are divergent. We analyzed whole blood RNA sequences, serum cytokines, and formalin fixed heart tissues from these patients using a computational toolbox of two gene signatures, i.e., the 166-gene viral pandemic (ViP) signature, and its 20-gene severe (s)ViP subset that were developed in the context of SARS-CoV-2 infection and a 13-transcript signature previously demonstrated to be diagnostic for KD. Our analyses revealed that KD and MIS-C are on the same continuum of the host immune response as COVID-19 but diverge with two different cardiac phenotypes. The ViP signatures helped unravel the nature of the host immune response (IL15-centric) in MIS-C and KD, reveal unique targetable cytokine pathways in MIS-C, place MIS-C farther along in the spectrum in severity compared to KD and pinpoint key clinical (reduced cardiac function) and laboratory (thrombocytopenia and eosinopenia) parameters that can be useful to monitor severity.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.11.439347v1" target="_blank">An AI-guided invariant signature places MIS-C with Kawasaki disease in a continuum of host immune responses</a>
</div></li>
<li><strong>Prediction and evolution of the molecular fitness of SARS-CoV-2 variants: Introducing SpikePro</strong> -
<div>
The understanding of the molecular mechanisms driving the fitness of the SARS-CoV-2 virus and its mutational evolution is still a critical issue. We built a simplified computational model, called SpikePro, to predict the SARS-CoV-2 fitness from the amino acid sequence and structure of the spike protein. It contains three contributions: the viral transmissibility predicted from the stability of the spike protein, the infectivity computed in terms of the affinity of the spike protein for the ACE2 receptor, and the ability of the virus to escape from the human immune response based on the binding affinity of the spike protein for a set of neutralizing antibodies. Our model reproduces well the available experimental, epidemiological and clinical data on the impact of variants on the biophysical characteristics of the virus. For example, it is able to identify circulating viral strains that, by increasing their fitness, recently became dominant at the population level. SpikePro is a useful instrument for the genomic surveillance of the SARS-CoV-2 virus, since it predicts in a fast and accurate way the emergence of new viral strains and their dangerousness. It is freely available in the GitHub repository github.com/3BioCompBio/SpikeProSARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.11.439322v1" target="_blank">Prediction and evolution of the molecular fitness of SARS-CoV-2 variants: Introducing SpikePro</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rehabilitation for Patients With Persistent Symptoms Post COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Concentrated rehabilitation for patients with persistent symptoms post COVID-19<br/><b>Sponsors</b>:   Western Norway University of Applied Sciences;   Helse-Bergen HF<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy, Immunogenicity and Safety of Inactivated ERUCOV-VAC Compared With Placebo in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: ERUCOV-VAC 3 µg/0.5 ml Vaccine;   Biological: ERUCOV-VAC 6 µg/0.5 ml Vaccine;   Other: Placebo<br/><b>Sponsors</b>:   Health Institutes of Turkey;   Erciyes University Scientific Research Projects Coordination<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Three Different Doses of an Anti SARS-CoV-2 Hyperimmune Equine Serum in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Anti SARS-CoV-2 equine hyperimmune serum;   Biological: placebo<br/><b>Sponsors</b>:   Caja Costarricense de Seguro Social;   Universidad de Costa Rica;   Ministry of Health Costa Rica<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Viral Clearance, PK and Tolerability of Ensovibep in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: ensovibep<br/><b>Sponsor</b>:   Molecular Partners AG<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Nurse-Community Health Worker-Family Partnership Model: Addressing Uptake of COVID-19 Testing and Control Measures</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Behavioral: Nurse-Community-Family Partnership Intervention<br/><b>Sponsor</b>:   New York University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Exercise<br/><b>Sponsor</b>:   Medical University of Vienna<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of the Inactivated Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine Compared to Placebo</strong> - <b>Condition</b>:   COVID-19 Vaccine<br/><b>Interventions</b>:   Biological: Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine 4 µg/0.5 ml Vaccine;   Biological: Koçak-19 Inaktif Adjuvanlı COVID-19 Vaccine 6 µg/0.5 ml Vaccine;   Biological: Placebo<br/><b>Sponsor</b>:   Kocak Farma<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Dose Finding, Efficacy and Safety Study of Ensovibep (MP0420) in Ambulatory Adult Patients With Symptomatic COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: ensovibep;   Drug: Placebo<br/><b>Sponsors</b>:   Molecular Partners AG;   Novartis Pharmaceuticals;   Iqvia Pty Ltd;   Datamap;   SYNLAB Analytics &amp; Services Switzerland AG;   Q2 Solutions<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vitamin D, Omega-3, and Combination Vitamins B, C and Zinc Supplementation for the Treatment and Prevention of COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: Vitamin D;   Dietary Supplement: Omega DHA / EPA;   Dietary Supplement: Vitamin C, Vitamin B complex and Zinc Acetate<br/><b>Sponsors</b>:   Hospital de la Soledad;   Microclinic International<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Total-Body Parametric 18F-FDG PET of COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Device: uEXPLORER/mCT<br/><b>Sponsor</b>:   University of California, Davis<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on Sequential Immunization of Recombinant COVID-19 Vaccine (Ad5 Vector) and RBD-based Protein Subunit Vaccine</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: recombinant Ad5 vectored COVID-19 vaccine;   Biological: RBD-based protein subunit vaccine (ZF2001) against COVID-19;   Biological: trivalent split influenza vaccine<br/><b>Sponsor</b>:   Jiangsu Province Centers for Disease Control and Prevention<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Respiratory Tele Monitoring COVID 19 (TMR COVID-19)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Device: Radius PPG Tetherless Pulse Oximetry (Masimo);   Device: usual monitoring<br/><b>Sponsor</b>:   Assistance Publique Hopitaux De Marseille<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Omega-3 Oil Use in COVID-19 Patients in Qatar</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Omega 3 fatty acid<br/><b>Sponsor</b>:   Hamad Medical Corporation<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dual MRI for Cardiopulmonary COVID-19 Long Haulers</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Hyperpolarized 129Xenon gas<br/><b>Sponsor</b>:   Bastiaan Driehuys<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cetirizine and Famotidine for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Cetirizine and Famotidine;   Drug: Placebo<br/><b>Sponsor</b>:   Emory University<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice</strong> - Drugs targeting host proteins can act prophylactically to reduce viral burden early in disease and limit morbidity, even with antivirals and vaccination. Transmembrane serine protease 2 (TMPRSS2) is a human protease required for SARS-CoV-2 viral entry and may represent such a target. We hypothesized that drugs selected from proteins related by their tertiary structure, rather than their primary structure, were likely to interact with TMPRSS2. We created a structure-based phylogenetic…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives</strong> - The coronaviruses disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2) has become a major health problem, affecting more than 50 million people with over one million deaths globally. Effective antivirals are still lacking. Here, we optimized a high-content imaging platform and the plaque assay for viral output study using the legitimate model of human lung epithelial cells, Calu-3, to determine the anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Elucidation of the inhibitory activity of ivermectin with host nuclear importin alpha and several SARS-CoV-2 targets</strong> - Ivermectin (IVM) is an FDA-approved drug that has shown antiviral activity against a wide variety of viruses in recent years. IVM inhibits the formation of the importin-α/β1 heterodimeric complex responsible for the translocation and replication of various viral species proteins. Also, IVM hampers SARS-CoV-2 replication in vitro; however, the molecular mechanism through which IVM inhibits SARS-CoV-2 is not well understood. Previous studies have explored the molecular mechanism through which IVM…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In search of drugs to alleviate suppression of the host’s innate immune responses against SARS-CoV-2 using a molecular modeling approach</strong> - Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the novel SARS-CoV-2 evade the host innate immunity, and subsequently the adaptive immune response, employing one protease called Papain-like protease (PLpro). The PLpro and the 3CL main protease are responsible for the cleavage of the polyproteins encoded by the + sense RNA genome of the virus to produce several non-structured proteins (NSPs). However, the PLpro also performs…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reducing SARS-CoV-2 Pathological Protein Activity with Small Molecules</strong> - Coronaviruses are dangerous human and animal pathogens. The newly identified coronavirus SARS-CoV-2 is the causative agent of COVID-19 outbreak, which is a real threat to human health and life. The world has been struggling with this epidemic for about a year, yet there are still no targeted drugs and effective treatments are very limited. Due to the long process of developing new drugs, reposition of existing ones is one of the best ways to deal with an epidemic of emergency infectious…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Third force in the treatment of COVID-19: A systematic review and meta-analysis</strong> - CONCLUSION: Remdesivir is useful in the treatment of COVID-19 especially the severe disease. However, it should be used with caution since all the adverse effects are not known. We recommend Remdesivir as an alternative/third-force in the treatment of severe and critical COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiates infection by attachment of the surface-exposed spike glycoprotein to the host cell receptors. The spike glycoprotein (S) is a promising target for inducing immune responses and providing protection; thus the ongoing efforts for the SARS-CoV-2 vaccine and therapeutic developments are mostly spiraling around S glycoprotein. The matured functional spike glycoprotein is presented on the virion surface as trimers, which contain…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen</strong> - There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, their efficacy is still under evaluation. Here, we have screened existing drugs approved for human use in a variety of diseases, to compare how they counteract SARS-CoV-2-induced cytopathic effect and viral replication in vitro. Among the potential 72 antivirals tested herein that were previously…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tamarind (<em>Tamarindus indica</em> L.) Seed a Candidate Protein Source with Potential for Combating SARS-CoV-2 Infection in Obesity</strong> - CONCLUSION:: Thus, TTI may contribute to combating two severe overlapping problems with high cost and social complex implications, obesity and COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reviving chloroquine for anti-SARS-CoV-2 treatment with cucurbit[7]uril-based supramolecular formulation</strong> - The wide-spreading SARS-CoV-2 virus has put the world into boiling water for more than a year, however pharmacological therapies to act effectively against coronavirus disease 2019 (COVID-19) remain elusive. Chloroquine (CQ), an antimalarial drug, was found to exhibit promising antiviral activity in vitro and in vivo at a high dosage, thus CQ was approved by the FDA for the emergency use authorization (EUA) in the fight against COVID-19 in the US, but later was revoked the EUA status due to the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Identification of Novel Inhibitors of Human Angiotensin-converting Enzyme 2 and Main Protease of Sars-Cov-2: A Combination of in silico Methods for Treatment of COVID-19</strong> - The angiotensin-converting enzyme 2 (ACE2) and main protease (MPro), are the putative drug candidates for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we performed 3D-QSAR pharmacophore modeling and screened 1264479 ligands gathered from Pubchem and Zinc databases. Following the calculation of the ADMET properties, molecular docking was carried out. Moreover, the de novo ligand design was performed. MD simulation was then applied to survey the behavior of the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SMMPPI: a machine learning-based approach for prediction of modulators of protein-protein interactions and its application for identification of novel inhibitors for RBD:hACE2 interactions in SARS-CoV-2</strong> - Small molecule modulators of protein-protein interactions (PPIs) are being pursued as novel anticancer, antiviral and antimicrobial drug candidates. We have utilized a large data set of experimentally validated PPI modulators and developed machine learning classifiers for prediction of new small molecule modulators of PPI. Our analysis reveals that using random forest (RF) classifier, general PPI Modulators independent of PPI family can be predicted with ROC-AUC higher than 0.9, when training…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiviral and anti-inflammatory therapies in COVID-19</strong> - Összefoglaló. Az új típusú koronavírus-fertőzés (COVID-19) nagy terhet ró az egészségügyi ellátórendszerre és a társadalomra. A betegségnek három nagy szakasza van, melyek alapvetően meghatározzák a kezelést. Az I-IIA fázisban az antivirális, míg a IIB-III. fázisban a gyulladásgátló kezelés áll előtérben, melyhez intenzív terápiás, szupportív kezelés csatlakozik. A jelen ajánlás kizárólag a gyógyszeres kezelésre vonatkozik, és a rendelkezésre álló bizonyítékok alapján foglalja össze a terápiás…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target</strong> - The recent coronavirus disease 2019 (COVID-19), causing a global pandemic with devastating effects on healthcare and social-economic systems, has no special antiviral therapies available for human coronaviruses (CoVs). The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) possesses a non-structural protein (nsp14), with amino terminal domain coding for a proofreading exoribonuclease (ExoN) that is required for high-fidelity replication. The ability of CoVs during genome replication…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation</strong> - CONCLUSIONS: Thus, we developed a therapeutic strategy for COVID-19 based on inhalation of a modified siRNA-peptide dendrimer formulation. The developed medication is intended for inhalation treatmentof COVID-19 patients.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>5-(4-TERT-BUTOXY PHENYL)-3-(4N-OCTYLOXYPHENYL)-4,5-DIHYDROISOXAZOLE MOLECULE (C-I): A PROMISING DRUG FOR SARS-COV-2 (TARGET I) AND BLOOD CANCER (TARGET II)</strong> - The present invention relates to a method ofmolecular docking of crystalline compound (C-I) with SARS-COV 2 proteins and its repurposing with proteins of blood cancer, comprising the steps of ; employing an algorithmto carry molecular docking calculations of the crystalized compound (C-I); studying the compound computationally to understand the effect of binding groups with the atoms of the amino acids on at least four target proteins of SARS-COV 2; downloading the structure of the proteins; removing water molecules, co enzymes and inhibitors attached to the enzymes; drawing the structure using Chem Sketch software; converting the mol file into a PDB file; using crystalized compound (C-I) for comparative and drug repurposing with two other mutated proteins; docking compound into the groove of the proteins; saving format of docked molecules retrieved; and filtering and docking the best docked results. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN320884617">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USING CLINICAL ONTOLOGIES TO BUILD KNOWLEDGE BASED CLINICAL DECISION SUPPORT SYSTEM FOR NOVEL CORONAVIRUS (COVID-19) WITH THE ADOPTION OF TELECONFERENCING FOR THE PRIMARY HEALTH CENTRES/SATELLITE CLINICS OF ROYAL OMAN POLICE IN SULTANATE OF OMAN</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU320796026">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Peptides and their use in diagnosis of SARS-CoV-2 infection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU319943278">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A PROCESS FOR SUCCESSFUL MANAGEMENT OF COVID 19 POSITIVE PATIENTS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU319942709">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IN SILICO SCREENING OF ANTIMYCOBACTERIAL NATURAL COMPOUNDS WITH THE POTENTIAL TO DIRECTLY INHIBIT SARS COV 2</strong> - IN SILICO SCREENING OF ANTIMYCOBACTERIAL NATURAL COMPOUNDS WITH THE POTENTIAL TO DIRECTLY INHIBIT SARS COV 2Insilico screening of antimycobacterial natural compounds with the potential to directly inhibit SARS COV2 relates to the composition for treating SARS-COV-2 comprising the composition is about 0.1 – 99% and other pharmaceutically acceptable excipients. The composition also treats treating SARS, Ebola, Hepatitis-B and Hepatitis–C comprising the composition is about 0.1 – 99% and other pharmaceutically acceptable excipients. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN320777840">link</a></p></li>
<li><strong>Aronia-Mundspray</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Anordnung zum Versprühen einer Substanz in die menschliche Mundhöhle und/oder in den Rachen oder zum Trinken, dadurch gekennzeichnet, dass die Anordnung eine Flasche mit einer Substanz aufweist, die wenigstens Aroniasaft und eine Alkoholkomponente aufweist und einen Sprühkopf besitzt.
</p>
<ul>
<li><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE321222630">link</a></li>
</ul></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>INTERFASE ANTIBACTERIANA Y VIRICIDA PARA VENTILACION MECANICA NO INVASIVA</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=ES319943963">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种用于检测新型冠状病毒COVID-19的引物组及试剂盒</strong> - 本发明涉及生物技术领域，特别是涉及一种用于检测冠状病毒的引物组及试剂盒，所述引物组包括以下中的一对或多对：外侧引物对：所述外侧引物对包括如SEQ ID NO:1所示的上游引物F3和如SEQ ID NO:2所示的下游引物B3；内侧引物对：所述内侧引物对包括如SEQ ID NO:3所示的上游引物FIP和如SEQ ID NO:4所示的下游引物BIP；环引物对：所述环引物对包括如SEQ ID NO:5所示的上游引物LF和如SEQ ID NO:6所示的下游引物LB。试剂盒包括所述引物组。本发明在一个管中整合了RT‑LAMP和CRISPR，能依据两次颜色变化检测病毒和各种靶标核酸。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN321132047">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>新冠病毒中和性抗体检测试剂盒</strong> - 本发明提供一种新冠病毒中和性抗体检测试剂盒。所述试剂盒基于BAS‑HTRF技术，主要包含：生物素标记的hACE2、新冠病毒棘突蛋白RBD‑Tag1、能量供体Streptavidin‑Eu cryptate、能量受体MAb Anti‑Tag1‑d2和新冠病毒中和性抗体。本发明将BAS和HTRF两种技术相结合，用于筛选新型冠状病毒中和性抗体，3小时内即可实现筛选，且操作简单，无需经过多次洗板过程。BAS和HTRF联用大大提升了反应灵敏度，且两种体系都能最大限度地减少非特异的干扰，适用于血清样品的检测。该方法可实现高通量检测，对解决大批量样品的新冠病毒中和性抗体的检测具有重要意义。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN321131958">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Infektionsschutzmaske</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Infektionsschutzmaske (1) zum Schutz vor Übertragung von Infektionskrankheiten mit einer Außen - und einer Innenseite (2,3) sowie Haltemitteln (5) zum Befestigen der Infektionsschutzmaske (1) am Kopf eines Maskenträgers, dadurch gekennzeichnet, dass an der Infektionsschutzmaske (1) mindestens eine Testoberfläche (6) zum Nachweis von Auslösern einer Infektionskrankheit derart angeordnet ist, dass diese bei korrekt angelegter Infektionsschutzmaske (1) mit der Ausatemluft des Maskenträgers unmittelbar in Kontakt gelangt.</p></li>
</ul>
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<ul>
<li><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE321222652">link</a></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Limits of Political Debate</strong> - I.B.M. taught a machine to debate policy questions. What can it teach us about the limits of rhetorical persuasion? - <a href="https://www.newyorker.com/news/annals-of-populism/the-limits-of-political-debate">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Moms Who Are Battling Climate Change</strong> - A new initiative seeks to tap into mothers’ concern for the world their children are inheriting. - <a href="https://www.newyorker.com/news/news-desk/the-moms-who-are-battling-climate-change">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Mystery of Breakthrough COVID-19 Infections</strong> - There is nothing surprising about cases like mine, but they do have a psychological impact. - <a href="https://www.newyorker.com/news/our-columnists/the-mystery-of-breakthrough-covid-19-infections">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia Beat the World to a Vaccine, so Why Is It Falling Behind on Vaccinations?</strong> - The problem, it seems, is both supply and demand. - <a href="https://www.newyorker.com/news/daily-comment/russia-beat-the-world-to-a-vaccine-so-why-is-it-falling-behind-on-vaccinations">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Last Time a Vaccine Saved America</strong> - Sixty-six years ago, people celebrated the polio vaccine by embracing in the streets. Our vaccine story is both more extraordinary and more complicated. - <a href="https://www.newyorker.com/science/annals-of-medicine/the-last-time-a-vaccine-saved-america">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>From beans and rice to BBQ: Muslim Americans’ Ramadan cuisine reflects their diversity</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/8Fp2WSdVKUZp8fN8GGkHK2b0dEk=/59x0:4774x3536/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69117835/GettyImages_696331586.0.jpg"/>
<figcaption>
A man calls Muslims to prayer before breaking their Ramadan fast by eating halal Mexican tacos from a food truck in Santa Ana, California, in 2017. | Mark Ralston/AFP/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Iftar, or breaking fast, is more than pita and hummus.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5RU0Me">
The month of <a href="https://www.vox.com/2017/5/25/11851766/what-is-ramadan-2021-start-date-muslim-islam-about">Ramadan</a> begins today and Muslims will spend the next four weeks fasting and dedicating time to worship. But even though most Muslims will abstain from eating or drinking between dawn and dusk, this doesn’t make food any less important. In fact, the process of deciding what to eat for iftar — the meal that breaks the day’s fast — can be long and complicated, especially when coupled with midday cravings and coffee-withdrawal headaches.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LEuj47">
But what Muslims eat during Ramadan, and how, goes beyond the stereotypical imagery of a family eating from a communal platter of rice and meat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6YzdF2">
A Google search for “Ramadan food” will likely result in images of samosas or recipes for lentil soup, which can offer an unnecessarily narrow view of who Muslims are and the dishes they like to cook and eat. While many Muslims worldwide do eat these foods, and most adhere to the <a href="https://www.icv.org.au/about/about-islam-overview/what-is-halal-a-guide-for-non-muslims/">halal</a> dietary standard — meaning foods that are religiously permissible; for instance, pork and alcohol are not<strong> </strong>— Ramadan cuisine has no boundaries and brings up a larger issue of inclusivity<strong> </strong>in Muslim American communities.<strong> </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PTYiRS">
A common misconception is that the Muslim faith is synonymous with Arab or South Asian cultures. But while people who are originally from the Middle East-North Africa region do contribute to the largest percentage of Muslim Americans, almost <a href="https://www.pewforum.org/2017/07/26/demographic-portrait-of-muslim-americans/#racial-classifications">30 percent</a> of Muslims in the US are Asian, while <a href="https://www.pewforum.org/2017/07/26/demographic-portrait-of-muslim-americans/#racial-classifications">one-fifth</a> are Black.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="56xlqh">
It goes without saying that these people represent many cultures, traditions, and cuisines, all of which they incorporate into religious events. So even though mosque events may overwhelmingly serve hummus and pita bread, this isn’t representative of the people who go to consume it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wugQuk">
This is something that Nazima Qureshi, a practicing nutritionist and co-founder of <a href="https://thehealthymuslims.com/">the Healthy Muslims</a>, has noticed. “[Religious] communities are created by the stakeholders at that mosque and a lot of times, unfortunately, it’s a very ethnic base, so you’ll have the South Asian-led mosques and the Middle Eastern mosques,” Qureshi told Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GDJNS0">
This leadership plays a big role in the decision-making and tends to exclude people from cultures that have less concentrated Muslim populations, something that Qureshi thinks should change. “Muslims come from so many different cultures,” she said, “so as a nutritionist, I try to incorporate a lot of different flavors to accurately reflect the Muslim community.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oJqX2d">
Qureshi said that many of her Muslim clients feel like they have to give up their cultural food in order to eat healthy, so she tries to reverse this perspective by celebrating what her clients (literally) bring to the table.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sZLv6a">
In my family, for example, Ramadan is a time to experiment with the vast array of dishes in our family cookbooks. I come from a mixed North African, Pakistani, and Quebecois background, so Wednesday’s iftar could be a tajine stew while on Thursday we might have chicken korma.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g33NJO">
I talked to three Muslim Americans, who value their cultural cuisines as well as their faith, about how their intersecting identities are reflected in the ways they observe Ramadan. Their stories have been edited and condensed.
</p>
<h3 id="fQtB3B">
<strong>Sahla Denton, 21, Cottage Grove, Oregon</strong>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7XA4Mm">
I’m half Mexican, half Jamaican, and I grew up with both of those cultures equally. But I’m also Muslim, which has a big influence on my family’s lifestyle. Since we’re from such different ethnic backgrounds, we don’t have a lot of traditions that other Muslim families have, so we’ve made a lot of our own.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZW5GiM">
One thing we’ve had to do in general is adapt our traditional dishes because there are a lot of Mexican and Jamaican dishes that aren’t initially halal. For example, Mexicans use a lot of pork fat, so we have to alter even the regular beans and rice. A lot of Jamaican cakes use rum, so we’ve had to find ingredients that balance the sugar other than alcohol. Our non-Muslim extended family has also adapted to us — like now all our aunties know how to make dishes that are good for us to eat, and it’s brought us together a lot more. One of our family’s staple dishes, that we’ll definitely be eating this Ramadan, is escovitch, which is a Jamaican dish made of fish and topped with onions, carrots, and bell peppers tossed in vinegar.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/fEgOC-PK0T_c4ZuYufnHX_KYXh4=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22437784/5bd0e3c0_b3d9_45ad_90f6_734860065dc1.jpg"/> <cite>Courtesy of Sahla Denton</cite>
<figcaption>
The Denton farm.
</figcaption>
</figure>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/E1BVd450hylxTS48E1NJBS12moo=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22437785/ec4bd7ae_06c9_41aa_ac25_ea24fa24dda2.jpg"/> <cite>Courtesy of Sahla Denton</cite>
<figcaption>
The Denton family produces much of the food they eat themselves.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Oz4Yn1">
As Muslims, we believe in taking care of the land, animals, and plants we benefit from, which was one of the values we’ve had since starting our family farm. We produce most of the food we eat, and if we have anything extra, we try to redistribute that.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s6abmt">
In fact, since the beginning of the pandemic, there has been an active food pantry in town where a lot of local farmers donate extra produce and animal products. My dad and I were some of the first volunteers to stock the pantry with milk and eggs from our farm animals when it opened. We will definitely continue doing that this year during Ramadan, and then once we start harvesting, we’ll have produce to give as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yNEzar">
One of my favorite Ramadan memories was when I was little and we used to go to the mosque for iftar. It would be me and my friend, and we’d have to help the little kids serve their food, and so I remember going back and forth to the food line so many times, but it was a lot of fun. The food was all really good because it was usually a potluck, so there was Mexican food, there was Pakistani food, there was food from all over the place on one table.
</p>
<h3 id="BJX2vm">
<strong>Dawood Yasin, 51, Berkeley, California</strong>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6zhbop">
Ramadan, for me, is proximity to God through subtraction to make space for addition. And so the subtraction obviously is food, and the addition is worship. This Ramadan I’m hoping to experiment with a simple diet, where I will break my fast with dates and bone broth, but I still love to cook.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nnfVtm">
My family originated from the Cape Verde Islands off the coast of Senegal, and we have our traditional foods like jag (beans and rice). But over the past two years I’ve been putting energy and intentionality into American barbecue. On the 17th of April, it will be 25 years since I converted to Islam, and for most of that time I wasn’t able to eat barbecue because no one made it halal.<strong> </strong>You’re not going to see an iftar in the mosque where they’re serving barbecued chicken and cornbread. It’s biryani and kebabs, you know, Mediterranean or South Asian cuisine. Which is great, I mean, everyone has their own inclination. But I wanted to expose more people to the possibilities of making this cuisine halal, and the response has been incredible.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/p4qbh_j19iPANvwvJTLgQEXj19M=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22436613/WhatsApp_Image_2021_04_08_at_9.53.36_AM.jpeg"/> <cite>Courtesy of Dawood Yasin</cite>
<figcaption>
Dawood Yasin set out to make halal barbecue, and succeeded.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GVceRi">
I see food as an expression of love to my family. Because if I love you, then I’m going to ensure that the best form of protein, vegetables, and food in general, is what I’m serving you. And if that means I have to go get it myself I will. I’ve spent full weeks at a time bow-hunting on backcountry trails and trekking through mountains to fish. I started this hashtag on social media <a href="https://www.instagram.com/dawood_yasin/?hl=en">#getyourownhalal</a>, which to me is the coupling of being outdoors and getting the best food for your health.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4wj0NE">
I actually don’t see a separation between wellness and religion. When I look at religiosity, I see it as a lifestyle, so there’s a symbiotic relationship between the two: If I’m unhealthy, I can’t worship properly. When I was 45 years old, I had a knee injury and I couldn’t prostrate to complete the Muslim prayer for six months. I had to pray in a chair during that time and I thought to myself, imagine if this was a perpetual state? I missed prostrating and putting my head onto the ground, and I knew that if my lifestyle was ever the cause of restricting my worship, I would have to address it. One of the aims and purposes of Islam is preservation of life, because there can be no preservation of religion if there is no life.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vCk7nP">
<strong>Seba Ismail, 19, Boston, Massachusetts</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BZfTuI">
I have a really big sweet tooth, so my favorite Ramadan dishes are desserts. We’re Egyptian, so my mom makes atayef,<em> </em>which is a sweet dumpling filled with cream, and we only have them during Ramadan because my mom says she wants us to savor it more and really appreciate it. I used to beg her to make them for my birthday and she would always say “no, you gotta wait until Ramadan,” so as a kid I would always get super excited for when the month started because it was the only time I could eat them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EoBpMC">
This year I won’t have that because I’m spending Ramadan on campus in Pennsylvania, and since Ramadan for me has always been so tied to community, I’m kind of excited to experience it by myself. I feel like it’s more of a test for me and my relationship with God. In the past, Ramadan would be my mom telling me to go to the mosque for prayers, or going to iHop for <a href="https://www.muslimaid.org/media-centre/blog/suhoor-iftar-and-fasting/">suhoor</a><em> </em>with my hometown friends, and I feel like I relied on a lot of people for my Ramadan experience. Now it’s just myself, and I don’t really know how to do that, but it’s kind of cool.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/tQjsYSl2zYVIO5iYwurVb1U6PUg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22437405/C8F13AC2_6895_4525_A17E_A5D746163E83.jpg"/> <cite>Courtesy of Seba Ismail</cite>
<figcaption>
Seba Ismail is celebrating Ramadan as a college student for the first time.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D21qDZ">
My family is Nubian, so growing up I would get a lot of people asking me, “How are you Egyptian, if you’re Black?” And because I don’t wear the hijab, people are also surprised when they find out I’m Muslim. I feel like I had a really big identity crisis that came from a lot of misinformation and ignorance. A lot of people don’t know about the complicated past of <a href="https://www.trtworld.com/magazine/how-france-engineered-north-african-ethnic-rivalry-to-further-colonisation-33720">colonization in North Africa</a>, or the <a href="http://factsanddetails.com/world/cat56/sub404/entry-6151.html">slavery</a> that happened there, or the displacement of Indigenous groups. I don’t think we talk about the diversity of the Muslim community enough, like the Black Muslim population is huge<strong> — </strong>15 percent of the world’s Muslims live in <a href="https://www.pewforum.org/2009/10/07/mapping-the-global-muslim-population/">sub-Saharan Africa</a><strong> —</strong> but most people don’t know that.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XU5uSx">
Bucknell University has a primarily white population, so I get a lot of questions about Ramadan<strong> </strong>and fasting that Muslims joke about but that I’ve never had to answer before, like “You can’t<strong> </strong>even drink<strong> </strong>water?” “How does your body survive?” and “Do you just stand outside and like, look at the sun to see when you can eat?” A lot of these people have only ever seen Muslim people on TV, which is kind of shocking to me and frustrating at times. I’m still figuring out how to navigate it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8Ndkx7">
Growing up, my parents would always tell me, “you’re Egyptian,” and then I go to Egypt and they’re like, “you’re American,” and then in<strong> </strong>America, they’re like, “you’re neither.” But I think now I’ve found a space in between, where I can be somebody who doesn’t have to fit in one box or the other.
</p></li>
<li><strong>What the Supreme Court got wrong about homicides committed by cops</strong> -
<figure>
<img alt="A picture of George Floyd on cyclone fencing outside municipal buildings." src="https://cdn.vox-cdn.com/thumbor/DstIiFVI-wdwnqW2qBaLxWVfe0w=/334x0:6882x4911/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69117760/1232075056.0.jpg"/>
<figcaption>
Law enforcement stands guard as crews remove artwork from temporary fencing outside the Hennepin County Government Center on April 2, 2021, in Minneapolis, Minnesota. Demonstrations have been ongoing outside the Government Center as the trial of former Minneapolis police officer Derek Chauvin, who is charged with multiple counts of murder in the death of George Floyd, continues inside. | Stephen Maturen/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Rogue officers like Derek Chauvin probably won’t be deterred by good law, but excessively vague law encourages bad behavior.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ghmGsD">
On Wednesday, more than one week into the murder trial of former Minneapolis police officer Derek Chauvin for the killing of George Floyd, Chauvin’s lawyer read an excerpt from the department’s manual governing the use of force.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9uSfAG">
“The ‘reasonableness’ of a particular use of force,” the manual stated, “<a href="https://www.npr.org/sections/trial-over-killing-of-george-floyd/2021/04/07/985004569/watch-live-police-expert-testifying-against-chauvin-cites-use-of-excessive-force">must be judged from the perspective of the reasonable officer on the scene</a>, rather than with the 20/20 vision of hindsight.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CYCZG6">
Minneapolis <a href="https://heavy.com/news/minneapolis-police-department-training-manual/">revised its manual after Floyd’s death</a> to place <a href="https://post.ca.gov/Data/Sites/1/post_docs/training/PC832Materials/PC%20832%20Workbooks/PC_832_VOL_4_V-3.0.pdf">clearer and tighter constraints</a> on officers engaged in the use of force. But the vague rule laid out in the version of the manual that was in effect during Floyd’s fatal encounter with Chauvin is fairly typical of the guidance provided to officers in the field.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fL7lnW">
As Sgt. Jody Stiger, a member of the Los Angeles Police Department called by prosecutors in the Chauvin trial, testified, most police departments derive their policies governing the use of force from <a href="https://supreme.justia.com/cases/federal/us/490/386/"><em>Graham v. Connor</em></a><em>. Graham </em>is<em> </em>a 1989 Supreme Court case that, in the words of scholars Osagie Obasogie and Zachary Newman, “<a href="https://scholarlycommons.law.northwestern.edu/cgi/viewcontent.cgi?article=1343&amp;context=nulr">established the modern constitutional landscape for police excessive force claims</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="82Gv63">
The language Chauvin’s lawyer read from the police manual was <a href="https://supreme.justia.com/cases/federal/us/490/386/">lifted, word for word</a>, from the Court’s decision in <em>Graham</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PBcyMQ">
Authored by Chief Justice William Rehnquist, one of the primary proponents of a <a href="https://www.abajournal.com/magazine/article/mirandas_reprieve">tough-on-crime approach</a> that often animated the Court’s decisions during his tenure, the <em>Graham</em> opinion warns that police accused of using excessive force often have to make difficult decisions in highly stressful situations. In determining whether an officer acted reasonably, Rehnquist wrote for his Court, “the calculus of reasonableness must embody allowance for the fact that <a href="https://caselaw.findlaw.com/us-supreme-court/490/386.html">police officers are often forced to make split-second judgments</a> — in circumstances that are tense, uncertain, and rapidly evolving — about the amount of force that is necessary in a particular situation.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="C88xx4">
Perhaps even more significantly, <em>Graham</em> left cops with little guidance on just what limits the Constitution places on use of force by police. As then-University of Virginia law professor William Stuntz wrote six years after <em>Graham</em> was handed down, “<a href="https://repository.law.umich.edu/cgi/viewcontent.cgi?article=3107&amp;context=mlr">one searches in vain</a> for any body of case law that gives” <em>Graham</em>’s vague reasonableness standard “some content.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oyw6uk">
Yet, while some academics did criticize <em>Graham</em>’s<em> </em>approach early on, many prominent commentators outside of the academy <a href="https://www.washingtonpost.com/opinions/a-1989-supreme-court-ruling-is-unintentionally-providing-cover-for-police-brutality/2020/06/08/91cc7b0c-a9a7-11ea-94d2-d7bc43b26bf9_story.html">only</a> <a href="https://www.thenation.com/article/society/chauvin-supreme-court/">recently</a> have started to think of <em>Graham</em> as a major wrong turn by the Supreme Court. Though three justices joined a partial dissent by Justice Harry Blackmun that criticized some parts of Rehnquist’s decision, all nine justices agreed with most of Rehnquist’s reasoning. That includes Justice Thurgood Marshall, the legendary civil rights lawyer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KhpW3B">
But with the benefit of hindsight — and with the benefit of empirical evidence showing that clear legal rules lead to better policing — <em>Graham </em>now looks like a serious error by the Court. As Rachel Harmon, a law professor at the University of Virginia and author of <a href="https://www.amazon.com/Law-Police-Aspen-Casebook/dp/1454891130"><em>The Law of the Police</em></a><em>, </em>told me in an email, “<em>Graham</em> offers a standard focused on judging the use of force after it has happened,” and it “offers very little guidance to officers and departments about how to use force.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GaNglB">
It does little, in other words, to advise police on how they can avoid conduct that might needlessly injure or kill a criminal suspect.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9XMaSv">
It’s unlikely that clearer rules would have saved George Floyd’s life. As Minneapolis Police Chief Medaria Arradondo testified at Chauvin’s trial, Chauvin “absolutely” violated department policy when he knelt on Floyd’s neck after Floyd was already subdued and handcuffed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7CLXag">
But clear rules can ensure that cops tossed into a dangerous and uncertain situation can fall back on those rules, rather than making a potentially deadly decision with only their fear to guide them. As law professors Brandon Garrett and Seth Stoughton <a href="https://scholarship.law.duke.edu/cgi/viewcontent.cgi?article=6535&amp;context=faculty_scholarship">wrote in a 2017 article</a>, <em>Graham</em>’s “‘split-second’ approach presents obvious problems from the perspective of law enforcement supervisors, who cannot provide meaningful guidance about or oversight of how officers react in the moment in an objectively reasonable way.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="laspBe">
<em>Graham</em> was correct about one thing. Officers do sometimes find themselves in “tense, uncertain, and rapidly evolving” encounters where they have to make quick decisions about how to use force. But if we want these officers to make the right decision in these fraught moments, police departments need to provide them with clear guidance on how they should react.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I9rIMw">
And the Supreme Court’s vague “reasonableness” standard does nothing of the sort.
</p>
<h3 id="HHKkAG">
How clear rules can save lives
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FczEn3">
On a fall night in 1974, Officer Elton Hymon arrived at the scene of an alleged home break-in. He soon found Edward Garner, an <a href="https://slate.com/news-and-politics/2005/12/alito-s-blank-check-for-cops.html#:~:text=Edward%20Garner%20was%20a%2015,were%20found%20on%20his%20body.&amp;text=After%20Edward%20Garner's%20death%2C%20his,civil%20rights%20had%20been%20violated.">eighth-grade boy weighing about 110 pounds</a>, in the backyard of the home. Hymon later admitted that he was “reasonably sure” that Garner was unarmed. Yet, as Garner attempted to climb a fence at the edge of the yard, Hymon shot him in the back of the head and killed him.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rxvbqi">
Police later found a stolen purse and $10 in Garner’s possession.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5CtUEK">
The stunning thing about Garner’s death, which formed the basis of the Supreme Court’s decision in <a href="https://supreme.justia.com/cases/federal/us/471/1/"><em>Tennessee v. Garner</em></a> (1985), is that Officer Hymon had every reason to believe that he acted lawfully when he killed an unarmed 15-year-old boy who’d committed a fairly minor act of theft.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dn0eRH">
A Tennessee state law provided that, after an officer notifies a suspect of their intention to arrest the suspect, if “he either flee or forcibly resist, the officer may use all the necessary means to effect the arrest.” In other words, state law clearly permitted police to use deadly force against fleeing felony suspects.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="N6pfpl">
Nor was Tennessee particularly unusual in this regard. As Justice Sandra Day O’Connor noted in her dissenting opinion in <em>Garner</em>, in 1985 “nearly half the States” still followed a “venerable common law rule authorizing the use of deadly force if necessary to apprehend a fleeing felon.” As a 1736 treatise described that common law rule, “it is no felony” for a law enforcement officer to slay a suspect who “<a href="https://supreme.justia.com/cases/federal/us/471/1/">shall either resist or fly before they are apprehended</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yIcZfr">
<em>Garner</em>, which abandoned that common law rule in a 6-3 decision, represents a “<a href="https://scholarship.law.duke.edu/cgi/viewcontent.cgi?article=6535&amp;context=faculty_scholarship">high-water mark</a>” in the Court’s decisions governing use of force by police, according to Garrett and Stoughton. Unlike future decisions like <em>Graham</em>, <em>Garner</em> laid down a fairly clear rule that police could follow when determining whether to use deadly force against a fleeing suspect.
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6QOV5N">
Where the officer has probable cause to believe that the suspect poses a threat of serious physical harm, either to the officer or to others, it is not constitutionally unreasonable to prevent escape by using deadly force. Thus, if the suspect threatens the officer with a weapon or there is probable cause to believe that he has committed a crime involving the infliction or threatened infliction of serious physical harm, deadly force may be used if necessary to prevent escape, and if, where feasible, some warning has been given.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3p625r">
Under <em>Garner</em>, in other words, police would no longer use their own judgment to decide whether to fire on a fleeing suspect. The Court told police when they could use deadly force — if the suspect “poses a threat of serious physical harm,” if they “threaten[] the officer with a weapon,” or when the suspect “committed a crime involving the infliction or threatened infliction of serious physical harm” — and thus informed police that they could not use deadly force against other fleeing suspects.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6xoEPw">
The impact of <em>Garner</em> on police behavior was swift and dramatic. According to a 1994 study by criminologist Abraham Tennenbaum, homicides committed by police <a href="https://scholarlycommons.law.northwestern.edu/cgi/viewcontent.cgi?article=6811&amp;context=jclc">dropped about 16 percent in the nation as a whole</a> after <em>Garner </em>was decided. In states that previously followed the unconstitutional common law rule, “the reduction was approximately twenty-four percent (23.80%).”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oCvIDt">
A more recent appeals court decision bolsters the proposition that clear legal rules are effective in reducing police violence.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xQDXEv">
In <a href="https://scholar.google.com/scholar_case?case=16814097488745741272&amp;hl=en&amp;as_sdt=6&amp;as_vis=1&amp;oi=scholarr"><em>Estate of Armstrong v. Village of Pinehurst</em></a> (2016), the United States Court of Appeals for the Fourth Circuit heard an allegation that police used excessive force when they repeatedly used a taser to subdue a mentally ill man, who died during his encounter with the police. Though the Fourth Circuit ruled in favor of the cops, on the theory that the officers were protected under a doctrine known as “<a href="https://www.vox.com/2020/6/3/21277104/qualified-immunity-cops-constitution-shaniz-west-supreme-court">qualified immunity</a>,” the court also laid down several limits on the use of tasers by police.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VhMueB">
“A police officer may <em>only</em> use serious injurious force, like a taser, when an objectively reasonable officer would conclude that the circumstances present a risk of immediate danger that could be mitigated by the use of force,” Judge Stephanie Thacker wrote for her court. She added that “‘physical resistance’ is not synonymous with ‘risk of immediate danger.’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5ncqx4">
The Fourth Circuit oversees federal litigation in Maryland, Virginia, West Virginia, North Carolina, and South Carolina, and a 2017 report by Reuters found that eight major cities in those states adopted stricter policies governing the use of tasers by police in the immediate wake of the <em>Armstrong</em> decision. These policies proved <a href="https://www.reuters.com/article/usa-taser-ruling/special-report-breathe-ronald-breathe-the-court-case-curbing-taser-use-idUSL2N1L70TH">very successful in reducing the use of tasers</a>.
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DYJIrE">
In Baltimore, police used Tasers 47 percent fewer times last year than in 2015, according to records reviewed by Reuters. Deployments fell 65 percent in Virginia Beach; 60 percent in Greensboro, North Carolina; 55 percent in Charleston, South Carolina; and 52 percent in Huntington, West Virginia. Norfolk, Virginia, saw deployments plunge 95 percent.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ip4h8J">
As Professor Harmon told me, cases like <em>Garner</em> and <em>Armstrong</em> demonstrate that “when courts provide clearer guidance, it can make a difference.” Regarding the <em>Armstrong</em> case, Harmon told me that she “would want to know more about what officers used instead of tasers before throwing a victory parade, but it does illustrate the power of the law, when courts actually provide specific and meaningful guidance to the police.”
</p>
<h3 id="9En7Ua">
The Supreme Court moved away from giving clear guidance to police after <em>Garner</em>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Tv3oxy">
The facts of <a href="https://supreme.justia.com/cases/federal/us/490/386/"><em>Graham v. Connor</em></a> are as shocking as the facts are in <em>Garner</em>, even though they did not result in anyone’s death.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Dg5fSY">
Dethorne Graham was a Black man and a diabetic living in Charlotte, North Carolina, in 1984, when he felt the beginning of an insulin reaction. Because such a reaction is treated with sugar, Graham asked a friend to drive him to a convenience store so he could buy some orange juice. But when they arrived at the store, there was a long line. Fearing he would not be able to buy the juice fast enough, Graham immediately left and asked his friend to take him to a friend’s house instead.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TJFOpU">
A police officer witnessed Graham’s very brief visit to the store and deemed it suspicious, because the cop pulled Graham and his friend over and would not let the two men go even after Graham’s friend explained Graham’s medical condition to the cop.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aSOTbP">
At one point, while Graham was waiting for the officer to let him go, he got out of the car, ran around it twice, and then passed out on the curb. Erratic behavior <a href="https://casetext.com/case/burns-v-city-of-redwood-city-2">can be a symptom of a diabetic emergency</a>, but the police apparently took Graham’s behavior as a sign of something sinister. After more officers arrived on the scene, Graham was handcuffed and forced face-down onto the car’s hood. When Graham told the police to check his wallet for a decal indicating that he is diabetic, an officer told him to “shut up.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VCkJm8">
They eventually let him go after they received a report that Graham hadn’t done anything wrong at the convenience store.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gLstwN">
And yet, despite these disturbing facts, the Supreme Court’s decision emphasized that police must deal with “tense, uncertain, and rapidly evolving” situations when they encounter someone like Dethorne Graham.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mcDD6d">
<em>Graham</em> didn’t say that there are no limits on police conduct. In addition to holding that police must behave as a “reasonable officer” would behave, the Court also listed several factors that lower courts could consider when an officer is accused of excessive force, “including the severity of the crime at issue, whether the suspect poses an immediate threat to the safety of the officers or others, and whether he is actively resisting arrest or attempting to evade arrest by flight.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xfjXtA">
But these were simply factors that could be considered, not bright-line rules that gave clear guidance to police about what kind of conduct is permitted. And the <em>Graham</em> case itself suggests that these factors offer little protection for many victims of excessive force.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ClkTZX">
After all, Graham himself committed no crime. He posed no threat to anyone, and he neither resisted arrest nor attempted to flee. But the Supreme Court sent his case back down to a trial court for a second hearing, and <a href="https://www.wnycstudios.org/podcasts/radiolabmoreperfect/episodes/mr-graham-and-reasonable-man">Graham ultimately lost his case</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cxHfgF">
One possible explanation for the lopsided vote in the <em>Graham </em>case — again, much of the decision was unanimous — is that the Supreme Court hands down decisions that are intended to be read and applied by lawyers and judges, not by police officers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LHkG0x">
Despite <em>Graham’s</em> admonition that judges should evaluate an officer’s conduct without “the 20/20 vision of hindsight,” courts are in the business of hindsight. Lawsuits, by their very nature, do not arise until <em>after </em>an alleged legal violation has occurred. So, when an officer is hauled into Court due to allegations of excessive force, <em>Graham</em> reminds judges that they will probably know more about the circumstances that led to that allegation than the officer reasonably could have known at the time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EvPzTF">
Yet, while <em>Graham</em>’s holding may offer a useful reminder to judges, we also know that police departments use decisions like <em>Graham</em> to shape their own policies and training manuals. And the sort of open-ended legal standards that judges are accustomed to applying to individual cases do not provide adequate guidance to police officers. A vague standard may be useful for a judge with a law degree, years of legal experience, and months to study the facts of a particular case. But such standards are inadequate for a cop who, <a href="https://www.pewresearch.org/fact-tank/2017/02/08/a-closer-look-at-police-officers-who-have-fired-their-weapon-on-duty/">often for the first and only time in their career</a>, is caught in a dangerous situation with their gun drawn.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tRf8H3">
Nevertheless, since <em>Graham</em>, the Court has only doubled down on its preference for vague, flexible standards over clear legal rules governing police. In <a href="https://scholar.google.com/scholar_case?case=18309800007705573319&amp;hl=en&amp;as_sdt=6&amp;as_vis=1&amp;oi=scholarr"><em>Scott v. Harris</em></a> (2007), for example, the Court ruled in favor of police officers who, during a high-speed chase, rammed a suspect’s car off the road and caused him serious injury.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8IprLy">
Yet, rather than evaluating this case under the fairly clear rule laid out in <em>Garner</em> — <em>Garner</em>, after all, was a case about when police can use potentially deadly force against a fleeing suspect — <em>Scott</em> arguably abandoned <em>Garner</em>’s approach altogether. While the fleeing motorist’s “attempt to craft an easy-to-apply legal test in the Fourth Amendment context is admirable,” Justice Antonin Scalia wrote for the Court, “in the end we must still slosh our way through the factbound morass of ‘reasonableness.’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zvoHwC">
“Whether or not Scott’s actions constituted application of ‘deadly force,’” Scalia added, “all that matters is whether Scott’s actions were reasonable.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PStzO6">
As one federal judge wrote just a few months after <em>Scott</em> was decided, under the <em>Scott</em> decision, “<a href="https://casetext.com/case/sharp-v-fisher">there is no <em>Garner</em> bright-line test</a>.” There is only a vague “reasonableness” test.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o2KLWW">
One major problem with this approach is that it gives virtually no guidance to police departments when they draft their own policies guiding the use of force, and it can lead individual officers to guess what kind of behavior is acceptable if they are in a situation that might require force. As Harmon, the UVA professor, writes, the Supreme Court’s current framework “<a href="https://papers.ssrn.com/sol3/papers.cfm?abstract_id=1129022">does not answer adequately the most basic questions about police uses of force</a>: when a police officer may use force against a citizen, how much force he may use, and what kinds of force are permissible.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="krl6Xk">
Again, it’s unlikely that a more rules-based approach, like the one the Court took in <em>Garner</em>, could have saved George Floyd’s life. Chauvin appears to have shown such extraordinary disregard for his department’s policies that even his own police chief testified against him at his murder trial.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="74hrIb">
But clear rules can and do save lives. According to Tennenbaum’s study of <em>Garner</em>, that decision “reduced the total number of police homicides <a href="https://scholarlycommons.law.northwestern.edu/cgi/viewcontent.cgi?article=6811&amp;context=jclc">by approximately sixty homicides a year</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l3CzwU">
That’s 60 people a year who would have died if the Court hadn’t given clear guidance to police officers.
</p></li>
<li><strong>Daunte Wright’s killing is a reminder of how quickly traffic stops can become deadly</strong> -
<figure>
<img alt="A loose tangle of people, largely in black, march through the middle of a street, surrounded by skyscrapers. One holds a large black and white sign reading, “Driving while Black should not be a death sentence.”" src="https://cdn.vox-cdn.com/thumbor/lGsLLWyhvEzbMzce8F5nMSILBHI=/693x0:6240x4160/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69116167/GettyImages_1312173623.0.jpg"/>
<figcaption>
Protesters in New York demonstrate to demand justice for Daunte Wright, who was killed in Brooklyn Center, Minnesota, during a traffic stop. | Spencer Platt/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Wright was killed by police just 10 miles away from where Derek Chauvin is on trial for the killing of George Floyd.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G9NPsk">
The police killing of Daunte Wright, a 20-year-old Black man, following a traffic stop in Brooklyn Center, Minnesota, comes as <a href="https://www.vox.com/22372672/derek-chauvin-trial-george-floyd-momentous-trauma-pain-police-reform">former police officer Derek Chauvin</a> is on trial for the killing of George Floyd roughly 10 miles to the south. Wright’s death,<strong> </strong>one of more than 260 fatal police shootings that have already happened this year, is yet another reminder of how quickly any police interaction can turn deadly — particularly for Black Americans.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="y9azfx">
Wright was stopped by police Sunday afternoon; his mother, Katie Wright, said her son called her as the stop was happening in order to ask her about insurance — she says the car had belonged to her, and she’d given it to Wright two weeks prior. His mother also said Wright told her officers informed him he was being stopped because there was an <a href="https://www.nytimes.com/2021/04/11/us/brooklyn-center-minnesota-police-shooting.html">air freshener hanging from the rearview mirror</a>. Most “objects suspended between the driver and the windshield,” including air fresheners, are <a href="https://www.revisor.mn.gov/statutes/cite/169.71">illegal in the state</a>. Police, however, said Monday that Wright was stopped for <a href="https://www.npr.org/2021/04/12/986458941/police-say-accidental-discharge-of-gun-led-to-daunte-wrights-death">having expired tags on his car</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y9WnqY">
Police also<strong> </strong>say they discovered after they pulled him over that there was a warrant out for Wright’s arrest. Wright’s mother says she heard him being told to exit his vehicle, and that “I heard police officers say, ‘Daunte, don’t run.’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1f582Y">
Police <a href="https://www.kare11.com/article/news/local/curfew-lifted-brooklyn-center-police-shooting/89-00f84fad-9304-4d63-bc3b-1a97e93f9276">body camera video</a> released Monday afternoon shows Wright outside of the car, with his hands behind his back. As one officer moves to handcuff him, he breaks away, reentering his car. An officer attempts to pull him back out, while the body camera shows an officer aiming a gun at Wright.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QCqbuR">
That gun discharges; Wright was shot. The car pulls away. The officer with the firearm can be heard saying, “Oh shit, I just shot him.” The <a href="https://www.usatoday.com/story/news/nation/2021/04/12/daunte-wright-police-shooting-near-minneapolis-protest-what-to-know/7185768002/">chief of police at Brooklyn Center</a> said he believes the shot was an “accidental discharge,” and that, given the officer can be heard yelling “taser” that the officer drew their handgun in error.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ziLNnW">
Wright died a few blocks away from the shooting after hitting another vehicle. His girlfriend, who needed treatment for non-life-threatening injuries, was in the passenger seat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kFrGup">
The Minnesota Bureau of Criminal Apprehension — the law enforcement agency that oversaw the state investigation into George Floyd’s death — has begun a review of the shooting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YXBNPa">
“We want justice for Daunte,” Katie Wright said at a memorial following the shooting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jq8eAl">
Hundreds of Brooklyn Center residents protested late into the night in demonstrations that culminated in a <a href="https://www.mprnews.org/story/2021/04/11/authorities-investigating-police-shooting-in-brooklyn-center">rally outside of the Brooklyn Center Police Department</a>, which saw protesters demanding accountability as officers pushed them back with flash-bang grenades and tear gas.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0A0q85">
Police ultimately declared the rally — which featured some protesters throwing items at armored officers — an unlawful assembly and ordered the crowd to leave or be arrested.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WBaiGY">
Wright’s mother <a href="https://www.pbs.org/newshour/nation/daunte-wright-killing-by-police-in-minnesota-sparks-protests">called on the protesters to be peaceful</a> in their advocacy, saying, “All the violence, if it keeps going it’s only going to be about the violence. We need it to be about why my son got shot for no reason.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bPxefV">
Many parents have asked similar questions. More than 1,127 people were killed by police during 2020, according to <a href="https://mappingpoliceviolence.org">Mapping Police Violence</a>. And many of those parents have had Black children; the races of all those killed aren’t known, but of those that are, about 30 percent of those killed were Black.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QhpYD3">
The knowledge that a disproportionate number of Black Americans are killed by police can make every encounter feel dangerous. At another recent, prominent traffic stop — this one in Virginia — <a href="https://www.vox.com/e/22144470">2nd Lt. Caron Nazario</a>, a Black Latinx man, was confronted by officers who demanded, at gunpoint, that he exit his vehicle.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R3EQvu">
When Nazario told the officers, “I’m honestly afraid to get out,” one responded, “Yeah, you should be.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NFYPEE">
And he should have been.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GQzHZT">
Wright’s killing, the killing of Philando Castile (who died nearly five years ago not far from where Wright lived his last moments), the arrest and death of Sandra Bland, and the many other Black people killed are testament to the fact that traffic stops are inherently dangerous. And it has reignited debate over just how necessary traffic stops really are.
</p>
<h3 id="khUT23">
Traffic stops demonstrate police bias and can be dangerous for Black drivers
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="clvOob">
As University of Arkansas law professor Jordan Blair Woods wrote in the <a href="https://michiganlawreview.org/wp-content/uploads/2019/03/117MichLRev635_Woods.pdf">Michigan Law Review</a>, police, like many Black Americans, are taught to view stops as dangerous — not to those being stopped, but to themselves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="arCfQm">
“Police academies regularly show officer trainees videos of the most extreme cases of violence against officers during routine traffic stops in order to stress that mundane police work can quickly turn into a deadly situation if they become complacent on the scene or hesitate to use force,” Woods wrote.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SbhFgs">
But in a review of Florida’s traffic stop data from 2005 to 2014, Woods found this mindset to be unnecessary. Police, the data showed, had a 1 in 6.5 million chance of being killed during a traffic stop, and a 1 in 361,111 chance of being seriously injured. Overall, 98 percent of stops saw zero or minor injury to officers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gliJ2Q">
Citizens’ chances of surviving a routine stop with police don’t seem to be quite as good; a <a href="https://www.journals.uchicago.edu/doi/pdf/10.1086/703541">2019 study by Shea Streeter</a>, currently a postdoctoral fellow at the University of Michigan, found that in 2015, about 11 percent of police killings happened at traffic and pedestrian stops nationwide.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Yrg4gT">
Complicating matters for Black individuals is that they appear to be <a href="https://scholarship.law.duke.edu/cgi/viewcontent.cgi?referer=&amp;httpsredir=1&amp;article=1065&amp;context=dflsc">stopped more often</a> than white people — in some localities, by a large margin. The <a href="https://openpolicing.stanford.edu/findings/">Stanford Open Policing Project</a>, a database of more than 200 million traffic stops, found that in St. Paul, not far from where Wright was killed, Black drivers are a little more than three times more likely than white drivers to be pulled over; in San Jose, California, Black drivers are six times more likely to be stopped.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V6v5Wd">
Arguably, drivers of all races ought to be stopped at about the same rate — failing to signal or missing a sudden change in speed limit would seem to be mistakes anyone could make. This has led to a number of researchers trying to understand this disparity, and, in general, these studies suggest that the issue has to do with officer bias, conscious or unconscious, that casts Black people as inherently more dangerous than their white counterparts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uI1SGI">
Tied to this idea is the question of what stops are for. As a group of University of North Carolina at Chapel Hill and Dartmouth College researchers led by UNC political science professor Frank R. Baumgartner wrote in a <a href="https://scholarship.law.duke.edu/cgi/viewcontent.cgi?referer=&amp;httpsredir=1&amp;article=1065&amp;context=dflsc">2017 paper</a>, in many departments, traffic stops are meant to serve a dual purpose: as a deterrent for the person stopped, and as a chance to do some investigative work for the officer. In many ways, this system is akin to the stop-and-frisk technique, a practice <a href="https://www.vox.com/first-person/2020/2/14/21136892/stop-and-frisk-bloomberg-activist">most prominently used in New York City</a> that was meant to uncover criminal behavior through street searches. The program was ruled unconstitutional.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7RBg37">
As Baumgartner wrote, “officers are trained to use traffic stops as a general enforcement strategy aimed at reducing violent crime or drug trafficking. When officers are serving these broader goals, they are making an investigatory stop, and these stops have little (if anything) to do with traffic safety and everything to do with who looks suspicious.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XFrNIY">
If Black drivers are seen as looking more suspicious and police are trained to view traffic stops as dangerous in general, this creates a serious problem. When a Black driver is stopped, the interaction is more likely to begin with the officer even more on guard for trouble than they might otherwise be.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SqLAQg">
This can lead to the kind of rapid escalation seen in Nazario’s case, in which officers attempted to manage the stop through violence: first with a weapon and threats, and later with nonlethal force. Body camera footage released during Chauvin’s trial, for example, shows an officer drawing his weapon shortly after approaching Floyd’s vehicle and yelling at him to “Put your fucking hands up right now.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0jZgYj">
All of this puts Black drivers in mortal danger. Law enforcement representatives have argued the stops are necessary — “we find drugs, evidence of other crimes … it’s a very valuable tool,” Kevin Lawrence, the Texas Municipal Police Association’s executive director told the <a href="https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2020/09/03/police-pretext-traffic-stops-need-to-end-some-lawmakers-say">Pew Charitable Trusts</a> in 2019 — but those discoveries are rare. Nationally, about 4 percent of stops resulted in arrests in 2015, according to the <a href="https://www.bjs.gov/content/pub/pdf/cpp15.pdf">Bureau of Justice Statistics</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LrTsJz">
This has a number of activists and elected officials questioning whether the risks traffic stops pose to drivers — particularly Black drivers — are worth such a small number of arrests.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8apPfi">
<a href="https://www.nytimes.com/2021/02/24/us/berkeley-police.html">Berkeley</a>, for instance, recently approved a plan to prohibit officers from conducting traffic stops for violations that have nothing to do with safety; <a href="https://www.sfchronicle.com/bayarea/article/To-curb-racial-bias-Oakland-police-are-pulling-14839567.php">Oakland</a> has a similar policy in place. Other places, including <a href="https://theappeal.org/traffic-enforcement-without-police/">Montgomery County, Maryland</a>, and <a href="https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2020/09/03/police-pretext-traffic-stops-need-to-end-some-lawmakers-say">Cambridge, Massachusetts</a>, have contemplated such measures as well. <a href="https://www.washingtonpost.com/transportation/2019/10/01/bowser-does-an-end-run-around-dc-council-transfers-speed-red-light-camera-program-ddot/">Washington, DC</a>, stripped its police department of some of its authority to regulate traffic laws, empowering its transportation department to do enforcement instead. <a href="https://apnews.com/article/bronx-arrests-traffic-archive-new-york-c93fa5fc03f25c2b625d36e4c75d1691">New York’s attorney general</a> has recommended New York City make a similar change.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r2ilaZ">
The long-term effectiveness of such measures remains to be seen. But they represent a step toward reform and a step away from the kind of policing that has left Wright dead.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Suyash Mehta: ‘It takes a while to get used to being an NBA referee’</strong> - NBA referee Suyash Mehta, the first person of Indian origin to become an official in the world’s most prestigious league for basketball, discusses his journey</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hockey player Balbir Singh Junior dead</strong> - Balbir Singh Junior was part of the Punjab State hockey team and also captained Panjab University team.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New Zealand Cricket Awards: Kane Williamson wins Sir Richard Hadlee Medal for fourth time</strong> - In bowler friendly conditions, Williamson recorded his top international score of 251 against the West Indies in Hamilton.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bhuvneshwar wins ICC Player of the Month award for exploits against England</strong> - Bhuvneshwar became the third successive Indian recipient of the award since its inception early this year.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2021 | RCB look to consolidate position as SRH eye first win</strong> - Having put up a decent performance in the first game, RCB will be strengthened further when the immensely-talented Devdutt Padikkal makes the team after his recovery from COVID-19</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>EAM Jaishankar holds talks with French counterpart Le Drian</strong> - After the talks, Mr. Jaishankar said India and France will advance their shared post-COVID-19 agenda through “close collaboration”</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Two Al-Badr militants among five arrested in Jammu &amp; Kashmir</strong> - “Incriminating material, including arms and ammunition, have been recovered,” a police spokesperson said.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Samagra’s ‘Hello World’ for English learning</strong> - An adaptation of ‘Hello English’ to suit the online mode of education</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Data | Dissecting India’s second COVID-19 wave</strong> - Since April 3, India has been consistently recording the highest number of daily cases globally, surpassing the U.S. and Brazil on an average</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Juvenile held for murdering mother in Chidambaram</strong> - The Chidambaram taluk police on Tuesday arrested a 15-year-old boy on charges of allegedly murdering his 35-year-old mother at their house in Manalur</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Is Russia going to war with Ukraine and other questions</strong> - What you need to know about Russia’s troop build-up around eastern Ukraine.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gruppe S: German far-right group on trial for ‘terror plot’</strong> - Twelve men are accused of planning attacks on migrants, Muslims and politicians in Germany.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Denmark charges six from UK and US with cum-ex fraud</strong> - They are accused of defrauding the Danish treasury in a trading scam through a German bank.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>St Paul’s bomb plot: Norwegian man charged</strong> - He is said to have been in contact with a British woman who planned to kill herself in the cathedral.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haiti’s Moïse ‘won’t give up’ on freeing kidnapped clergy</strong> - A gang is demanding $1m in ransom for 10 people, most of them clergy, kidnapped on Sunday.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>This is Intel’s plan to dominate driverless car technology</strong> - Intel says its driverless tech will be ready in 2023—I’m skeptical. - <a href="https://arstechnica.com/?p=1756247">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New wooden satellite is part advertising, part student project</strong> - A cube sat with plywood sides is planned for a Rocketlab launch. - <a href="https://arstechnica.com/?p=1756436">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Report: Apple plans Apple TV/HomePod and iPad/HomePod hybrid products</strong> - Also: Mini LED display supply might make the new iPad Pro hard to find. - <a href="https://arstechnica.com/?p=1756296">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Free Software Foundation and RMS issue statements on Stallman’s return</strong> - Today, Stallman and the FSF board issued joint statements concerning his return. - <a href="https://arstechnica.com/?p=1756400">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>It’s too late for vaccines to save Michigan, CDC director explains</strong> - Vaccines take weeks to work; distancing and other health measures work immediately. - <a href="https://arstechnica.com/?p=1756350">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A man is walking along the Las Vegas strip, and meets the most beautiful woman he’s ever seen….</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He starts talking to her, and to his luck he finds out she is a prostitute. So, he asks her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“How much for a hand-job?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“$5,000” she replies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“$5,000?? You must be nuts, no way.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Walk with me.” She replies. He agrees and they walk for a moment to end up in front of a restaurant. “You see this restaurant? I own this restaurant because men pay me $5,000 for hand jobs.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He ponders for a moment. “Damn, they must be pretty good then. Alright.” He brings her back to his hotel room. Gets the hand job, and as advertised; it is the best hand job he has ever had. After he finishes, he realizes how perfect she is and asks. “Okay, that was awesome. How much for a blow job?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“$15,000” she replies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“$15,000?!? You are out of your mind. No way!” He shouts
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Come to the window.” They walk to the window and she begins to point. “You see those three casinos? I own those casinos because men pay me $15,000 for blow jobs.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Fine, how can i say no?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Once again, it is the best blow job of his life. He is writhing in ecstasy after finishing, and practically in love with this woman. “Okay, I am gonna regret this. How much for the pussy?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Come to the window.” He follows her to the window, ready for anything. “Do you see all of Las Vegas?” She asks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“No way! You own all of Las Vegas?!” He exclaims, astounded.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“No..” she looks down. " But I would if I had a pussy…"
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MacGyverMacGuffin"> /u/MacGyverMacGuffin </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mpmtqn/a_man_is_walking_along_the_las_vegas_strip_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mpmtqn/a_man_is_walking_along_the_las_vegas_strip_and/">[comments]</a></span></p></li>
<li><strong>You have three cups of coffee and 20 sugar cubes? How do you put an odd number of sugar cubes into each cup of coffee using all 20 sugar cubes.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
1 cube in the first cup, 1 cube in the second, and 18 in the third because 18 is an odd number of sugar cubes to put in coffee.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/JaredLiwet"> /u/JaredLiwet </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mpwp8c/you_have_three_cups_of_coffee_and_20_sugar_cubes/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mpwp8c/you_have_three_cups_of_coffee_and_20_sugar_cubes/">[comments]</a></span></p></li>
<li><strong>A man brings some flowers home to his wife. She’s so surprised by his romantic gesture that she lays back on the dining table, throws her legs in the air and spreads them.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Her husband confused looks down and goes, “What’s that for?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His wife replies, “For the flowers of course.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He thinks for a moment and asks, “Don’t we have a vase?”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/timetofeedthemonster"> /u/timetofeedthemonster </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mpk6t8/a_man_brings_some_flowers_home_to_his_wife_shes/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mpk6t8/a_man_brings_some_flowers_home_to_his_wife_shes/">[comments]</a></span></p></li>
<li><strong>John O’Reilly hoisted his beer and said, “Here’s to spending the rest of me life, between the legs of me wife!”</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
That won him the top prize at the pub for the best toast of the night!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He went home and told his wife, Mary, “I won the prize for the best toast of the night.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She said, “Aye, did ye now. And what was your toast?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
John said, “Here’s to spending the rest of me life, sitting in church beside me wife.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Oh, that is very nice indeed, John!” Mary said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The next day, Mary ran into one of John’s drinking buddies on the street Corner. The man chuckled leeringly and said, “John won the prize the other night at the pub with a toast about you, Mary.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She said, “Aye, he told me, and I was a bit surprised myself. You know, he’s only been in there twice in the last four years. Once I had to pull him by the ears to make him come, and the other time he fell asleep”.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/jezarius"> /u/jezarius </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mpcyvi/john_oreilly_hoisted_his_beer_and_said_heres_to/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mpcyvi/john_oreilly_hoisted_his_beer_and_said_heres_to/">[comments]</a></span></p></li>
<li><strong>Happy Ramadan to all my Muslim brothers and sisters!</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
This month, lunch is on me. ;)
</p>
</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/cyxro"> /u/cyxro </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mq0g5q/happy_ramadan_to_all_my_muslim_brothers_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mq0g5q/happy_ramadan_to_all_my_muslim_brothers_and/">[comments]</a></span></p></li>
</ul>
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