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+ + + ++The COVID-19 pandemic is the first to be rapidly and sequentially measured by nation-wide PCR community testing for the presence of the viral RNA at a global scale. We take advantage of the novel “natural experiment” where diverse nations and major subnational regions implemented various policies including social distancing and vaccination at different times with different levels of stringency and adherence. Initially, case numbers expanding exponentially with doubling times of ~1-2 weeks. In the nations where lockdowns were not implemented or ineffectual, case numbers increased exponentially but then stabilized around 102-to-103 new infections (per km2 built-up area per day). Dynamics under strict lockdowns were perturbed and infections decayed to low levels. They rebounded following the lifting of the policies but converged on an equilibrium setpoint. Here we deploy a mathematical model which captures this behavior, incorporates a direct measure of lockdown efficacies, and allows derivation of a maximal estimate for the basic reproductive number Ro (mean 1.6-1.8). We were able to test this approach by comparing the approximated “herd immunity” to the vaccination coverage observed that corresponded to rapid declines in community infections during 2021. The estimates reported here agree with the observed phenomena. Moreover, the decay rates d (0.4-0.5) and rebound rates r0 (0.2-0.3) were similar throughout the pandemic and among all the nations and regions studied. Finally, a longitudinal analysis comparing multiple national and regional results provides insights on the underlying epidemiology of SARS-CoV-2 and lockdown and vaccine efficacy, as well as evidence for the existence of an endemic steady state of COVID-19. +
++Objective: To investigate the reactogenicity and immunogenicity of the fourth dose using mRNA vaccines after different three-dose regimens and to compare the 30 μg BNT162b2 and 50 μg mRNA-1273 vaccines. Methods: This prospective cohort study was conducted between June and October 2022. The self-recorded reactogenicity was evaluated on the subsequent 7 days after a fourth dose. Binding and neutralizing activity of antibodies against the Omicron BA.4/5 variants were determined. Results: Overall, 292 healthy adults were enrolled and received BNT162b2 or mRNA-1273. Reactogenicity was mild to moderate and well-tolerated after a few days. Sixty-five individuals were excluded. Thus, 227 eligible individuals received a fourth booster dose of BNT162b2 (n=109) and mRNA-1273 (n=118). Most participants, regardless the type of previous three dose regimens, elicited a significantly high level of binding antibodies and neutralizing activity against the Omicron BA.4/5 28 days after a fourth dose. The neutralizing activity against the Omicron BA.4/5 between the BNT162b2 (82.8%) and mRNA-1273 (84.2%) groups was comparable with a median ratio of 1.02. Conclusion: This study found that the BNT162b2 and mRNA-1273 vaccines can be used as a fourth booster dose for individuals who were previously immunized with any prior mix and match three dose COVID-19 vaccine. +
++Objective: To identify a cohort of COVID-19 cases, including when evidence of virus positivity was only mentioned in the clinical text, not in structured laboratory data in the electronic health record (EHR). Materials and Methods: Statistical classifiers were trained on feature representations derived from unstructured text in patient electronic health records (EHRs). We used a proxy dataset of patients with COVID-19 polymerase chain reaction (PCR) tests for training. We selected a model based on performance on our proxy dataset and applied it to instances without COVID-19 PCR tests. A physician reviewed a sample of these instances to validate the classifier. Results: On the test split of the proxy dataset, our best classifier obtained 0.56 F1, 0.6 precision, and 0.52 recall scores for SARS-CoV2 positive cases. In an expert validation, the classifier correctly identified 90.8% (79/87) as COVID-19 positive and 97.8% (91/93) as not SARS-CoV2 positive. The classifier identified an additional 960 positive cases that did not have SARS-CoV2 lab tests in hospital, and only 177 of those cases had the ICD-10 code for COVID-19. Discussion: Proxy dataset performance may be worse because these instances sometimes include discussion of pending lab tests. The most predictive features are meaningful and interpretable. The type of external test that was performed is rarely mentioned. Conclusion: COVID-19 cases that had testing done outside of the hospital can be reliably detected from the text in EHRs. Training on a proxy dataset was a suitable method for developing a highly performant classifier without labor intensive labeling efforts. +
++Abstract BACKGROUND A definitive COVID-19 infection typically is diagnosed by laboratory tests, including real-time, reverse-transcriptase Polymerase Chain Reaction (PCR)-based testing. These currently available COVID-19 tests require the patient to provide an extra-corporeal specimen and the results may not be immediate. Consequently, a variety of rapid antigen tests for COVID-19, all with a wide range of accuracy in terms of sensitivity and specificity, has proliferated (1,2). These rapid tests now represent a significantly larger proportion of all testing done for COVID-19, yet suffer from requiring a physical specimen from the nose or mouth and waiting 15 minutes for most. As a solution, we propose a non-invasive, trans-cutaneous, real-time viral detection device, based on the principles of Raman spectroscopy and machine learning. It does not require any extra-corporeal specimens and can be configured for self-administration. It can be easily used by non-experts and does not require medical training. Our approach suggests that our non-invasive, transcutaneous method may be broadly useful not only in COVID-19 diagnosis, but also in other diagnoses. METHODS 160 COVID positive (+) patients and 316 COVID negative (-) patients prospectively underwent nasal PCR testing concurrently with testing using our non-invasive, transcutaneous, immediate viral detector. Both the PCR and our experimental viral detector tests were performed side-by-side on outpatients (N=389) as well as inpatients (N= 87) at Holy Name Medical Center in Teaneck, NJ between June 2021 and August, 2022. The spectroscopic data were generated using an 830nm Raman System with SpectraSoft (W2 Innovations)and then, using machine learning, processed to provide an immediate prediction. A unique patient- interface for finger insertion enabled the application of Raman spectroscopy to viral detection in humans. RESULTS The data analysis algorithm demonstrates that there is an informative Raman spectrum output from the device, and that individual Raman peaks vary between cases and controls. Our proof-of-concept study yields encouraging results, with a specificity for COVID-19 of 0.75, and a sensitivity (including asymptomatic patients) of 0.80. CONCLUSIONS The combination of Raman spectroscopy, artificial intelligence, and our unique patient-interface admitting only a patient finger achieved test results of 0.75 specificity and 0.80 sensitivity for COVID-19 testing in this first in human proof-of-concept study. More significantly, the predictability improved with increasing data. +
++The incidence of long COVID is substantial, even in people who did not require hospitalization for acute COVID–19. The pathobiological mechanisms of long COVID and the role of early viral kinetics in its development are largely unknown. Seventy–three non-hospitalized adult participants were enrolled within approximately 48 hours of their first positive SARS–CoV–2 RT–PCR test, and mid–turbinate nasal and saliva samples were collected up to 9 times within the first 45 days after enrollment. Samples were assayed for SARS–CoV–2 using RT–PCR and additional test results were abstracted from the clinical record. Each participant indicated the presence and severity of 49 long COVID symptoms at 1, 3, 6, 12, and 18 months post–COVID–19 diagnosis. Time from acute COVID–19 illness onset to SARS-CoV-2 RNA clearance greater or less than 28 days was tested for association with the presence or absence of each of 49 long COVID symptoms at 90 or more days from acute COVID–19 symptom onset. Brain fog and muscle pain at 90 or more days after acute COVID–19 onset were negatively associated with viral RNA clearance within 28 days of acute COVID–19 onset with adjustment for age, sex, BMI over 25, and COVID vaccination status prior to COVID–19 (brain fog: aRR 0.46, 95% CI 0.22 – 0.95; muscle pain: aRR 0.28, 95% CI 0.08 – 0.94). This work indicates that at least two long COVID symptoms, brain fog and muscle pain, at 90 or more days from acute COVID–19 onset are specifically associated with longer time to clearance of SARS–CoV–2 RNA from the upper respiratory tract. +
++Accurate, reliable, and timely estimates of pathogen variant risk are essential for informing effective public health responses to infectious diseases. Despite decades of use for influenza vaccine strain selection and PCR-based molecular diagnostics, data on pathogen variant prevalence and growth advantage has only risen to its current prominence during the SARS-CoV-2 pandemic. However, such data are still often sparse: novel variants are initially rare or a region has limited sequencing. To ensure real-time estimates of risk are available in these types of data-sparse conditions, we develop a hierarchical modeling approach that estimates variant fitness advantage and prevalence by pooling data across geographic regions. We apply this method to estimate SARS-CoV-2 variant dynamics at the country-level and assess its stability with retrospective validation. Our results show that more stable and robust estimates can be obtained even when sequencing data are sparse, as compared to established, single-country estimation approaches. We discuss how this method can inform risk assessment of novel emerging variants and provide situational awareness on currently circulating variants, for a range of pathogens and use-cases. +
++Background: A recombinant, adjuvanted COVID-19 vaccine, SII-NVX-CoV2373 was manufactured in India and evaluated in Indian children and adolescents to assess safety and immunogenicity. Methods: This was a Phase 2/3 observer-blind, randomized, controlled immuno-bridging study in children and adolescents aged 2 to 17 years. Participants were randomly assigned in 3:1 ratio to receive two doses of SII-NVX-CoV2373 or placebo on day 1 and day 22. Solicited adverse events (AEs) were collected for 7 days after each vaccination. Unsolicited AEs were collected for 35 days following first dose and serious AEs (SAEs) and adverse events of special interest (AESI) were collected throughout the study. Anti S IgG and neutralizing antibodies against the SARS-CoV-2 were measured at baseline, day 22, day 36 and day 180. Variant immune responses were assessed in a subset of participants at baseline, day 36 and day 180. Primary objectives were to demonstrate non-inferiority of SII-NVX-CoV2373 in each pediatric age group (12 to 17 years and 2 to 11 years, separately) to that in adults in terms of ratio of titers of both anti-S IgG and neutralizing antibodies 14 days after the second dose (day 36). Non-inferiority was to be concluded if the lower bound of 95% CI of the ratio was >0.67. Results: A total of 920 children and adolescents (460 in each age cohort; 12 to 17 years and 2 to 11 years) were randomized and vaccinated. The demographic and baseline characteristics between the two groups were comparable in both age groups. After the second dose, there were more than 100-fold rise in anti-S IgG GMEUs and more than 84-fold rise in neutralizing antibodies GMTs from baseline in the participants who received SII-NVX-CoV2373. The lower bound of 95% CI of GMT ratios for anti-S IgG GMEUs and neutralizing antibodies in both age groups to those observed in Indian adults were >0.67, thus non-inferiority was met [Anti-S IgG GMT ratios 1.52 (1.38, 1.67), 1.20 (1.08, 1.34) and neutralizing antibodies GMT ratios 1.93 (1.70, 2.18), 1.33 (1.17, 1.50) for 2 to 11 years and 12 to 17 years groups, respectively]. The seroconversion rate was ≥ 98% (anti-S IgG) and ≥ 97.9 % (neutralizing antibodies) in both age groups, respectively. Similar findings were seen in the baseline seronegative participants. SII-NVX-CoV2373 also showed robust responses against various variants of concern. Injection site pain, tenderness, swelling, erythema and fever, headache, malaise, fatigue, were the common (≥5%) solicited adverse events which were transient and resolved without any sequelae. Throughout the study, only two causally unrelated SAEs and no AESI were reported. Conclusion: SII-NVX-CoV2373 has been found safe and well tolerated in children and adolescents of 2 to 17 years. The vaccine was highly immunogenic and the immune response was non-inferior to that in adults. +
++The omicron variant is thought to cause less olfactory dysfunction than previous variants of SARS-CoV-2, but the reported prevalence differs greatly between populations and studies. Our systematic review and meta-analysis provide information about regional differences in prevalence as well as an estimate of the global prevalence of olfactory dysfunction based on 62 studies reporting on nearly 626,035 patients infected with the omicron variant. Our estimate of the omicron-induced prevalence of olfactory dysfunction in populations of European ancestry is 11.7%, while it is significantly lower in all other populations, ranging between 1.9% and 4.9%. When ethnic differences and population sizes are taken into account, the global prevalence of omicron-induced olfactory dysfunction in adults is estimated at 3.7%. The effect of omicron on olfaction is twofold to tenfold lower than that of the alpha or delta variant, according to previous meta-analyses and our analysis of studies that directly compared prevalence of olfactory dysfunction between omicron and previous variants. The profile of prevalence differences between ethnicities mirrors the results of a recent genome-wide association study that implicated a gene locus encoding an odorant-metabolizing enzyme, UDP glycosyltransferase, to be linked to the extent of COVID-related loss of smell. Our analysis is consistent with the hypothesis that this enzyme contributes to the observed population differences. +
++As the number of confirmed COVID-19 cases now exceeds 100 million cases in the United States and continues to climb, concerns have been increasingly raised over the future public health and economic burden of long COVID including disability and concomitant declines in labor force participation. Only a handful of US population-based studies have explored sociodemographic and socioeconomic characteristics that put people at risk of long COVID or have investigated its mental health and socioeconomic sequelae. Herein, I report findings from the largest multivariable analysis to date using US nationally-representative data on 153,543 adults including 19,985 adults with long COVID to explore key predictors and sequelae of long COVID. An estimated 14.0% of adults aged 18-84 y (35.11 million adults) and 15.5% of working-aged adults aged 18-64 y (30.65 million adults) had developed long COVID by November 2022. Several sociodemographic and socioeconomic factors predicted long COVID including lower household income, being aged 30-49 y, Hispanic, female, gay/lesbian or bisexual, and divorced/separated. Even after accounting for such factors, having long COVID was linked to higher risks of recent unemployment, financial hardship, and anxiety and depressive symptomatology, with evidence of dose-response relationships. Overall, an estimated 27.7 million US adults aged 18-84 y and 24.2 million working-aged adults with long COVID who had been or may still be at risk of adverse socioeconomic and mental health outcomes. Lost work was further calculated to be the equivalent of 3 million workers annually, and the estimated annual lost earnings due to long COVID among working-aged adults totaled $175 billion. These preliminary findings highlight the substantial public health and economic implications of long COVID among Americans and should prompt further inquiry and intervention. +
++There is limited data directly comparing the effectiveness of COVID-19 vaccines. We compared rates of SARS-CoV-2 Omicron BA.1/2 infection in Australian adults during March to May 2022 who had received one of four COVID-19 vaccines in the last 14-63 days as either a primary course or a booster dose. As a primary course, compared to recipients of BNT162b2 mRNA vaccine, adjusted hazard ratios for SARS-CoV-2 infection were 1.03 (95%CI 0.82-1.30), 1.19 (0.95-1.49), 1.70 (1.46-1.97) for respectively mRNA-1273, ChAdOx-1 nCov-19 and NVX-CoV2373. For booster dose, respective adjusted hazard ratios compared to BNT162b2 mRNA vaccine were 1.02 (95%CI 1.00-1.04), 1.20 (1.10-1.32), 1.39 (1.20-1.60). Our findings suggest relatively higher effectiveness of ancestral strain mRNA vaccines against SARS-CoV-2 Omicron infection than viral vector and protein subunit vaccines, but further studies are required due to small numbers of recipients of ChAdOx-1 nCov-19 and NVX-CoV2373. +
+Digital Tools to Expand COVID-19 Testing in Exposed Individuals in Cameroon - Condition: COVID-19
Intervention: Other: Digital based contact tracing
Sponsors: Elizabeth Glaser Pediatric AIDS Foundation; Find
Recruiting
Evaluation of the Outcome of COVID-19 Patients Discharged Home on Oxygen Therapy - Condition: COVID-19
Intervention: Other: Phone satisfaction questionnaire
Sponsor: Centre Hospitalier René Dubos
Not yet recruiting
Postural Changes and Severe COVID-19 - Condition: COVID-19
Intervention: Behavioral: Postural interventions based on pulmonary imaging
Sponsor: Wuhan Union Hospital, China
Recruiting
A Chatbot to Enhance COVID-19 Knowledge - Condition: COVID-19
Interventions: Device: chatbot; Other: Printed educational booklet
Sponsor: Sun Yat-sen University
Not yet recruiting
Awaken Prone Positioning Ventinlation in COVID-19 Patients - Condition: COVID-19
Intervention: Procedure: Awaken prone positioning ventilation
Sponsor: Southeast University, China
Enrolling by invitation
Study of SHEN26 Capsule in Patients With Mild to Moderate COVID-19 - Condition: COVID-19
Interventions: Drug: SHEN26 dose 1; Drug: SHEN26 dose 2; Drug: SHEN26 placebo
Sponsor: Shenzhen Kexing Pharmaceutical Co., Ltd.
Recruiting
Bright Light Therapy for Post-COVID-19 Fatigue - Condition: Post COVID-19 Condition
Interventions: Device: Bright light therapy; Device: Dim red light therapy
Sponsor: Chinese University of Hong Kong
Not yet recruiting
Study on the Safety and Efficacy of Meplazumab for Injection Patients COVID-19 - Condition: COVID-19
Interventions: Biological: Meplazumab foe injection; Other: Normal saline
Sponsor: Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd
Not yet recruiting
Study on the Safety and Efficacy of Meplazumab for Injection in Severe Patients With COVID-19 - Condition: COVID-19
Interventions: Biological: Meplazumab for injection; Other: Normal saline
Sponsor: Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd
Not yet recruiting
A Phase 2 Study to Evaluate the Efficacy and Safety of QLS1128 Orally in Symptomatic Participants With Mild to Moderate COVID-19 - Condition: COVID-19
Interventions: Drug: QLS1128; Drug: Placebo
Sponsor: Qilu Pharmaceutical Co., Ltd.
Recruiting
Oropharyngeal Immunoprophylaxis With High Polyphenolic Olive Oil as Clinical Spectrum Mitigating Factor in COVID-19. - Condition: COVID-19
Intervention: Dietary Supplement: High polyphenolic olive oil. (Early harvest olive oil).
Sponsor: Hospital General Nuestra Señora del Prado
Completed
A Randomized, Phase I Study of DNA Vaccine OC-007 as a Booster Dose of COVID-19 Vaccine - Conditions: COVID-19 Respiratory Infection; COVID-19 Vaccine Adverse Reaction
Interventions: Biological: DNA vaccine OC-007; Other: Placebo
Sponsor: Matti Sällberg
Not yet recruiting
Evaluate the Efficacy and Safety of FB2001 for Inhalation in Patients With Mild to Moderate COVID-19 - Condition: Mild to Moderate COVID-19
Interventions: Drug: FB2001; Drug: FB2001 placebo
Sponsor: Frontier Biotechnologies Inc.
Recruiting
UC-MSCs in the Treatment of Severe and Critical COVID-19 Patients - Conditions: Mesenchymal Stem Cell; COVID-19 Pneumonia
Interventions: Biological: umbilical cord mesenchymal stem cells; Drug: paxlovid
Sponsor: Shanghai East Hospital
Recruiting
A Study of Positive Emotions With Long COVID-19 - Condition: Post-Acute COVID-19 Syndrome
Intervention: Behavioral: Microdosing of mindfulness
Sponsor: University of California, Davis
Not yet recruiting
SURFing SARS-CoV-2 inhibition - No abstract
Com probe implemented STexS II greatly enhances specificity in SARS-CoV-2 variant detection - The initial introduction of utilizing double helix structural oligonucleotides known as SNP typing with excellent specificity (STexS) in a standard PCR greatly improved the detection of single nucleotide polymorphisms (SNP) by enhancing amplification rates of primer-matching strands and interrupting mismatched strands by constant instability of kinetics regarding alignment attaching and detaching. The model was beneficial overall in detecting SNP variants consisting of large amounts of wildtype…
Characterization of RNA G-quadruplexes in porcine epidemic diarrhea virus genome and the antiviral activity of G-quadruplex ligands - Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus, has catastrophic impacts on the global pig industry. However, there are still no anti-PEDV drugs with accurate targets. G-quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA, and have attracted great attention as potential targets for antiviral strategy. In this study, we reported two putative G4-forming sequences (PQS) in S and Nsp5 genes of PEDV genome based on…
Thorectidiol A Isolated from the Marine Sponge Dactylospongia elegans Disrupts Interactions of the SARS-CoV-2 Spike Receptor Binding Domain with the Host ACE2 Receptor - Thorectidiols isolated from the marine sponge Dactylospongia elegans (family Thorectidae, order Dictyoceratida) collected in Papua New Guinea are a family of symmetrical and unsymmetrical dimeric biphenyl meroterpenoid stereoisomers presumed to be products of oxidative phenol coupling of a co-occurring racemic monomer, thorectidol (3). One member of the family, thorectidiol A (1), has been isolated in its natural form, and its structure has been elucidated by analysis of NMR, MS, and ECD data….
Chicken or Porcine Aminopeptidase N Mediates Cellular Entry of Pseudoviruses Carrying Spike Glycoprotein from the Avian Deltacoronaviruses HKU11, HKU13, and HKU17 - Members of deltacoronavirus (DCoV) have mostly been identified in diverse avian species as natural reservoirs, though the porcine DCoV (PDCoV) is a major swine enteropathogenic virus with global spread. The important role of aminopeptidase N (APN) orthologues from various mammalian and avian species in PDCoV cellular entry and interspecies transmission has been revealed recently. In this study, comparative analysis indicated that three avian DCoVs, bulbul DCoV HKU11, munia DCoV HKU13, and…
Amelioration of Lung Fibrosis by Total Flavonoids of Astragalus via Inflammatory Modulation and Epithelium Regeneration - Idiopathic Pulmonary Fibrosis (IPF) is identifiable by the excessive increase of mesenchyme paired with the loss of epithelium. Total flavonoids of Astragalus (TFA), the main biologically active ingredient of the traditional Chinese medicine, Astragalus membranaceus (Huangqi), shows outstanding effects on treating pulmonary disorders, including COVID-19-associated pulmonary dysfunctions. This study was designed to evaluate the efficacy of TFA on treating pulmonary fibrosis and the possible…
Antiviral Potential of Melissa officinalis L.: A Literature Review - The use of synthetic drugs has increased in recent years; however, herbal medicine is yet more trusted among a huge population worldwide; This could be due to minimal side effects, affordable prices, and traditional beliefs. Lemongrass (Melissa officinalis) has been widely used for reducing stress and anxiety, increasing appetite and sleep, reducing pain, healing wounds, and treating poisonous insect bites and bee stings for a long time. Today, research has shown that this plant can also fight…
Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies - The advent of SARS-CoV-2, the causative agent of COVID-19, and its worldwide impact on global health, have provided the impetus for the development of effective countermeasures that can be deployed against the virus, including vaccines, monoclonal antibodies, and direct-acting antivirals (DAAs). Despite these efforts, the current paucity of DAAs has created an urgent need for the creation of an enhanced and diversified portfolio of broadly acting agents with different mechanisms of action that…
Paradoxical interaction between nirmatrelvir/ritonavir and voriconazole in a patient with COVID-19 - This case is based on a drug interaction between nirmatrelvir/ritonavir (approved drug for COVID-19) and voriconazole is presented, possibly derived from the bidirectional effect of ritonavir on the 2 main voriconazole metabolising enzymes (cytochrome P450 3A and 2C19) ritonavir inhibits the former and induces the latter respectively. According to the main pharmacotherapeutic information databases, in the interaction between both drugs, a decrease in the area under the curve of voriconazole is…
PCSK9 Inhibition During the Inflammatory Stage of SARS-CoV-2 Infection - CONCLUSIONS: PCSK9 inhibition compared with placebo reduced the primary endpoint of death or need for intubation and IL-6 levels in severe COVID-19. Patients with more intense inflammation at randomization had better survival with PCSK9 inhibition vs placebo, indicating that inflammatory intensity may drive therapeutic benefits. (Impact of PCSK9 Inhibition on Clinical Outcome in Patients During the Inflammatory Stage of the COVID-19 [IMPACT-SIRIO 5]; NCT04941105).
Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach - In this study, an integrated in silico-in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, i.e., main protease (M^(pro)) and papain-like protease (PL^(pro)), were selected as targets for the in silico study. Virtual hits were obtained by docking more than 140,000 NPs and NP derivatives available in-house and from commercial sources, and 38 virtual hits were experimentally validated in vitro using two enzyme-based…
Potential of plant extracts in targeting SARS-CoV-2 main protease: an in vitro and in silico study - The deaths caused by the covid-19 pandemic have recently decreased due to a worldwide effort in vaccination campaigns. However, even vaccinated people can develop a severe form of the disease that requires ICU admission. As a result, the search for antiviral drugs to treat these severe cases has become a necessity. In this context, natural products are an interesting alternative to synthetic medicines used in drug repositioning, as they have been consumed for a long time through traditional…
Functionalized Fullerene for Inhibition of SARS-CoV-2 Variants - As virus outbreaks continue to pose a challenge, a nonspecific viral inhibitor can provide significant benefits, especially against respiratory viruses. Polyglycerol sulfates recently emerge as promising agents that mediate interactions between cells and viruses through electrostatics, leading to virus inhibition. Similarly, hydrophobic C(60) fullerene can prevent virus infection via interactions with hydrophobic cavities of surface proteins. Here, two strategies are combined to inhibit…
Detailed Insights into the Inhibitory Mechanism of New Ebselen Derivatives against Main Protease (Mpro) of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) - SARS-CoV-2 main protease (M(pro)/3CL(pro)) is a crucial target for therapeutics, which is responsible for viral polyprotein cleavage and plays a vital role in virus replication and survival. Recent studies suggest that 2-phenylbenzisoselenazol-3(2H)-one (ebselen) is a potent covalent inhibitor of M^(pro), which affects its enzymatic activity and virus survival. Herein, we synthesized various ebselen derivatives to understand the mechanism of M^(pro) inhibition by ebselen. Using ebselen…
SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses - SARS-CoV-2 infection can trigger strong inflammatory responses and cause severe lung damage in COVID-19 patients with critical illness. However, the molecular mechanisms by which the infection induces excessive inflammatory responses are not fully understood. Here, we report that SARS-CoV-2 infection results in the formation of viral Z-RNA in the cytoplasm of infected cells and thereby activates the ZBP1-RIPK3 pathway. Pharmacological inhibition of RIPK3 by GSK872 or genetic deletion of MLKL…
Republican Debt-Ceiling Madness Is About to Begin Again - Holding the debt limit hostage could have dire economic consequences for Americans. - link
Is Prince Harry’s “Spare” a Political Manifesto? - His own feelings about the value of the monarchy, he writes, are “complicated.” - link
How Russia’s New Commander in Ukraine Could Change the War - Why has Vladimir Putin promoted Valery Gerasimov, who helped plan the disastrous initial invasion last year, to lead the fight? - link
Why Is Columbia Kicking Out a Beloved Preschool? - The Red Balloon is part of the university’s progressive history, but it may not have a future. - link
There’s Only One Thing to Call Biden’s New Scandal: Political Malpractice - And that’s assuming things don’t get worse. - link
+Study: UK patients died more often and were readmitted more frequently after hospital mergers. +
++The past few decades have seen the growing concentration of hospitals and other health care services in the United States. In 2005, about half of US hospitals were part of a larger system. By 2017, two-thirds were. Most places in the US have what is considered a highly concentrated hospital market, which means one company operates most of the hospital facilities in the area. +
++This concentration is one of the most significant trends in American health care. It can lead to fewer options for patients and higher prices. Recent research has found that higher hospital prices are driving much of the recent increases in US health care spending. Hospitals that are acquired by larger systems sometimes cut important services, such as maternity care, forcing patients to travel hours to receive medical services they used to be able to get locally. +
++As I wrote late last year, America’s smaller community hospitals, many of which operate with a deficit, have often been forced to explore mergers with larger health systems to keep the doors open. +
++Higher costs are bad news for patients. But it’s notoriously difficult to analyze the clinical consequences of these mergers: Does a more concentrated hospital system also lead to worse care? There are many variables in play, and mergers can disrupt the health care market (through those higher prices) in ways that make it difficult to isolate how any changes to a hospital’s operations post-merger have contributed to any increase in deaths or readmissions. +
++A new study of hospital mergers in the United Kingdom is trying to shed light on that question. It found that after hospitals merge, patients are more likely to die during or soon after a hospital stay and they are also more likely to be readmitted a second time in the near term, according to new research from scholars at Cornell University and the University of London. These increases begin within a few months of the merger and persist for at least two years, the researchers found. +
++Most UK hospitals are publicly owned, but the national government has still made mergers a priority in order to improve its health system’s performance by merging hospitals that are struggling financially with another hospital. In practice, a UK hospital merger often looks a lot like a US hospital merger does: Separate facilities that once operated under separate management are brought under the purview of one board and one senior leadership team. +
++The size of the mergers’ impact, especially on mortality, is substantial: The likelihood that a patient will die in the hospital or within 30 days of being discharged increased by 0.4 percentage points, a 27 percent increase from the pre-merger mortality rate of 1.4 percent. They are also 11 percent more likely to be readmitted within 30 days of being discharged from the hospital. +
++At the 139 hospitals involved in 13 different mergers from 2006 to 2015, this increase in mortality and readmissions translated to 60 additional deaths and 140 readmissions when compared to a large control group of UK hospitals that did not experience a merger over that period. +
++“Mergers and acquisitions raise a number of antitrust concerns, chief among them that market consolidation may lead to higher prices or poorer product quality,” the authors, the University of London’s Elena Ashtari Tafti and Cornell’s Thomas Hoe, wrote to open their conclusions. “Both of these effects are incredibly important in health care markets, which have experienced significant merger activity over the past two decades, and where prices and quality can literally be a matter of life or death.” +
++In the US, the evidence on how mergers affect the quality of care is limited and mixed. But the UK and its National Health Service are arguably an ideal setting to study these effects, the authors argue, because payment and the mix of payers do not change as a result of the merger. That removes one variable that can confound similar research in the US. They studied the period from 2006 to 2015 in part because it followed reforms to the NHS that gave patients more choice about where to seek care and put hospitals on a fixed budget for their operations. +
++Ashtari Tafti and Hoe tout that special feature of the UK health system as a virtue of their research. They also point out that their findings are the logical extension of prior studies that found the quality of care was better in more competitive hospital markets. But they acknowledged more work needs to be done to determine whether the results would be replicated in a different health system with a different payment structure, such as the US. +
++I asked Hannah Neprash, a health care economist at the University of Minnesota, who did not contribute to the research, whether she thought what the researchers detected in the UK would be applicable in the US. She pointed out that the study sample was fairly small (13 mergers affecting 139 acute care hospitals; for context, the UK control group included about 1,100 hospitals and the US has about 5,000 similar facilities). She also noted some of the specific findings (such as a particularly sizable increase in kidney-related mortality) that demand more scrutiny and explanation, and the researchers cited how specific changes in a hospital’s operations post-merger affected clinical quality should be the subject of future inquiry. +
++“For me, there’s a lingering question about generalizability, but that isn’t really because of the differences between US and UK hospital stuff,” she said. +
++Patients in the US already report a worse experience when treated at hospitals that have gone through a merger. This new research suggests that there is also a measurable effect on the more objective quality of care they receive. +
++The US health system, given its perverse financial incentives, has driven more and more hospitals to merge together in an attempt to stay open, to operate more efficiently, and in theory, to better coordinate services for their patients. Federal regulators have tried to stop those mergers at times, but they face various obstacles and constraints. Hospitals have meanwhile made the case that consolidation does actually benefit patients — with little empirical evidence to contradict them — to justify those mergers to public officials. +
++But the lingering concern has been that the quality of care could deteriorate if hospitals face less competition. What Ashtari Tafti and Hoe saw in their research indicates those concerns should be taken seriously as regulators review future mergers and acquisitions. +
+A new study suggests Russian trolls had little impact. But there was more going on. +
++The Russian trolls were overhyped. +
++That’s the implication from a new study in Nature Communications, written by a team of six academics who tried to assess whether the Russian government’s Twitter propaganda effort during the 2016 campaign actually changed users’ minds. “We find no evidence of a meaningful relationship between exposure to the Russian foreign influence campaign and changes in attitudes, polarization, or voting behavior,” the authors wrote. +
++This isn’t a surprise to me — I’ve long believed the Russian troll farms had little impact. But with the afterlife of the Trump-Russia scandal remaining fiercely contested — with many on the right and some “heterodox” leftists continuing to question whether Russia did anything at all of significance — it’s worth looking back and taking stock of what the Russian government did do that year. Because it wasn’t nothing. +
++Basically, the Russian government tried to intervene in the 2016 election, and it did so in two main ways. +
++First, there was that social media propaganda effort: the Russian trolls. On Facebook, Twitter, and Instagram, Russians posed as Americans and posted content designed to inflame US political tensions, often attacking Hillary Clinton and supporting Donald Trump. This happened, and it was rather unusual, but as this new study corroborates, there’s no convincing reason to believe it made any difference to Americans’ voting behavior. The Russian propaganda was just some more drops in an ocean of media and social media messaging that Americans were swimming in. +
++Second, and more consequentially, there were the stolen emails: the hack-and-leak. Russian intelligence officers hacked and obtained emails and documents from many top Democrats and had those put out publicly — giving some to WikiLeaks, providing others to reporters, and posting more on websites they controlled. +
++These hacks and releases did make an impact — notably, they were a negative story for Clinton that simmered throughout the last month of the campaign. But did they swing the election? That is, in a counterfactual world with no Russian interference, would Clinton have won? My assessment is “probably not,” but it’s difficult to conclusively say for sure. +
++Still, these interventions were quite unusual in the context of American elections; it was appropriate to treat them as a big deal and understandable that Americans might resent Russia trying to swing their votes. There were real victims here, in the people who saw their private correspondence dumped on the internet, and it’s certainly important to deter interventions like this from happening in the future. +
++The Russian social media propaganda effort was carried out by the Internet Research Agency, an organization based in St. Petersburg and funded by Yevgeny Prigozhin — a Russian oligarch close to Putin who also heads the Wagner Group (a paramilitary group active in the Russia-Ukraine war). The IRA is not officially a government agency, but a bipartisan report from the Senate Intelligence Committee concluded that “the Russian government tasked and supported” its 2016 election interference efforts. +
++Employees of the IRA created online accounts, claimed to be American, and posted inflammatory or trollish material about US politics. Much of this material was rather crude or silly, but the overall thrust was clear: It tended to praise Trump and attack Hillary Clinton. The IRA also paid for online ads featuring the following pro-Trump, anti-Clinton messaging, as seen in this table from an indictment brought by Robert Mueller’s team, which was tasked with investigating Russian interference with the election: +
+ ++All this was the source of much fascination and media attention when news of it emerged after the election. Facebook estimated that IRA messaging reached as many as 126 million people on their platform, which certainly seems like a big number. “It leaves all of us who use social media to keep up with friends, share photos and follow news wondering: How’d the Russians get to me?” the Washington Post’s Geoffrey Fowler wrote in November 2017. +
++But there were always solid reasons to doubt that the IRA posts had much of an impact, despite those scary numbers. If I scroll through Twitter for just 15 minutes, I could be “reached” by messages from hundreds of sources, if not more. I’ll use the metaphor again that these were drops in an ocean: Americans were swimming in messaging about the 2016 election from all sorts of traditional media and social media sources for months (as well as the campaigns and their ads), and there was no reason to believe Russian posts or ads had extra-special persuasive powers that all those other messages lacked. +
++Now, the authors of the Nature Communications study — Gregory Eady, Tom Paskhalis, Jan Zilinsky, Richard Bonneau, Jonathan Nagler, and Joshua A. Tucker — have conducted their own analysis driving this home. Back in 2016, they surveyed nearly 1,500 US Twitter users at various points in the campaign, returning to those same respondents to track how their opinions changed. They also analyzed all the Twitter accounts those respondents followed to see how many were exposed to Internet Research Agency content. +
++Overall, they found that 70 percent of exposures to IRA posts were concentrated among 1 percent of their respondents, and those respondents were mostly highly partisan Republicans who already liked Trump. That makes sense, given what we know of social media — if you go looking for anti-Clinton, pro-Trump content, that’s what you’ll find, either due to algorithmic recommendation or the accounts you follow simply retweeting messages they agreed with without knowing too much about who was saying them. And that’s the sort of content the IRA was providing. But the finding suggests the IRA messaging was not finely calibrated to target wavering swing voters. +
++The authors also put the exposure to this messaging in perspective by finding that users had far more posts from traditional media and politicians in their timelines than Russian trolls — an “order of magnitude” more, they write. And ultimately, their survey results “did not detect any meaningful relationships between exposure to posts from Russian foreign influence accounts and changes in respondents’ attitudes on the issues, political polarization, or voting behavior.” +
++Now, it is true that this is just a study of Twitter posts and not other social media platforms like Facebook where the IRA was also active. The overall logic is sound, though. Americans can certainly resent the Russian effort to propagandize their views, and Mueller’s team argued that much of what they did violated US laws. But the Russians didn’t have some magically effective messaging that warped Americans’ minds and forced them to support Donald Trump. +
++In 2016, the GRU, Russia’s foreign military intelligence agency, went on a spree of hacking of Americans involved in politics or government. +
++Using simple spear-phishing emails (links to a fake Google page that asked people to enter their password), they obtained access to the email accounts of Clinton campaign chair John Podesta, as well as several Clinton staffers, volunteers, and advisers. According to the Mueller report, they spear-phished an employee of the Democratic Congressional Campaign Committee, which got them credentials for access to the DCCC computer network and eventually the connected Democratic National Committee network. The hackers then used malware to scoop up emails and documents. +
++(Some critics of the Russia investigation like journalist Matt Taibbi still purport to be skeptical that the hacks were the Russian government’s doing, but Mueller’s report and his indictment of 12 Russian intelligence officers provide a wealth of specific detailed allegations about exactly how these hacks happened and which specific officers and units in the GRU were responsible. This is inconvenient for the Russiagate skeptics, so they tend to ignore it.) +
++Foreign hacking is far from unusual; the Chinese government, for instance, was said to have hacked Barack Obama’s and John McCain’s presidential campaigns in 2008, and the US has likely done a fair amount of it as well. The jarring departure was what happened next: The stolen information began showing up publicly, in massive accounts. (Another unusual aspect was that one major candidate openly welcomed this intervention, with Trump publicly urging Russia to “find” more Clinton emails.) +
++The GRU used the persona of “Guccifer 2.0” (“Guccifer” was a name used by a jailed Romanian hacker) and registered a website, DC Leaks, posting hacked material there and providing some to reporters. But two specific batches were saved for WikiLeaks, a nonprofit that had posted leaked US government material in the past. +
++First, in late July 2016, just before the Democratic National Convention, WikiLeaks posted thousands of DNC emails and revealed that many DNC members privately spoke of Bernie Sanders with disdain. The revelations drove DNC Chair Debbie Wasserman Schultz and other top staffers to resign, and overall made an ugly start for the Democratic convention. +
++Second, in early October 2016, WikiLeaks began posting Podesta’s emails — and would continue to post them, in batches, up through the election. The Podesta emails weren’t as explosive, but in anyone’s private email there will be embarrassing material they’d prefer to keep private, and if that embarrassing material is only being released about one candidate, there could be an impact. So each new release drove some media coverage, and they were touted constantly by Trump on the campaign trail, who often baselessly claimed they revealed some malfeasance or another. +
++Trump sank in the polls for the first half of October, as controversy over his Access Hollywood tape hit the news. In the second half of the month, the news cycle moved on and his poll numbers rebounded. He didn’t pass Clinton in the polls, but he got closer — close enough to pull out a win by less than 1 percentage point in three key swing states. +
++Yet I would be hesitant to claim that the drip-drip-drip of Podesta email coverage was responsible for Trump’s recovery. Part of it could simply be about Republican partisans briefly turned off by his scandals “coming home” to him before the election — a process that may have unfolded even if there had been no Russian interference. (Trump improved in the polls in the last half of October 2020, as well.) +
++The case could be made that, simply by keeping the words “Clinton” and “emails” in the news for a month, the Podesta releases hurt her campaign (since any coverage of the leaks would remind voters of a separate matter, the FBI investigation into Clinton’s emails). Still, it’s far easier to make the case that FBI Director James Comey’s late October letter saying new Clinton emails had been discovered changed the outcome, as Nate Silver has argued, than the Russian hack-and-leaks. The Comey letter was a discrete event that dominated headlines and preceded a sharp change in the polls, while the Podesta leaks were one of many stories simmering in the background throughout October. +
++So I’ve never been persuaded that Russia fully got Trump elected. That is a high bar, though, and despite the overhyped Russian trolls, it seems to me the hack-and-leak was a consequential intervention that damaged Clinton and the Democrats to some extent. And it really was an attempt to affect Americans’ votes and hurt a presidential candidate who Russia didn’t like — an attempt that violated US laws against hacking and disclosing campaign activity. The intervention was real, the investigation into it was justified, and the anger at the Russian government for what it tried to do is justified as well. +
+Biden can end the debt ceiling. But can he handle the bond market? +
++So it’s come to this: another debt ceiling crisis. +
++This is the fifth standoff I’ve covered as a reporter. There was the big one in 2011, of course, but then the 2013 standoff related to Obamacare, the lower-profile standoff in 2015, and the 2021 fight that required a temporary change to the Senate filibuster. I’m 32 years old. As I tell myself in the mirror every morning, that is not old. And I’m on my fifth debt ceiling crisis. All of this has happened before, and it will all happen again. +
++The first-best solution to the standoff between President Joe Biden and the new Republican majority in the House would be for the latter to simply relent and pass legislation repealing the debt ceiling, or at least raising it without strings attached. House Speaker Kevin McCarthy is clear he won’t do that; he got his speakership specifically by promising the least responsible members of his caucus that he’d hold the debt ceiling hostage. But past speakers in his position, notably John Boehner in 2013, have blinked and wound up passing a “clean” debt ceiling bill anyway. Hopefully he does the same. +
++The absolute worst solution to the standoff would be for the federal government to default: to stop paying interest on its loans, or paying for programs from Social Security to the military, sending the economy into recession and the world into a financial crisis. +
++Somewhere in the middle are the two likeliest outcomes. One is for Biden to, like President Barack Obama in 2011, come to the table and cut a deal with McCarthy for a debt ceiling hike in exchange for spending cuts. This would avoid a recession but likely involve cuts to important programs from education to health research, which could have major negative long-term repercussions. +
++The final option is for Biden to use executive action to render the debt ceiling moot. There are several ways for him to do this, which I ran through in this piece. The funniest involves minting a platinum coin worth hundreds of billions or trillions of dollars. The most boring involves issuing a novel kind of debt to fund the government. Somewhere in the middle are the options to invoke the 14th Amendment and claim the debt ceiling is unconstitutional, or to claim that obeying Congress’s previously passed spending and tax legislation forces the president to ignore the debt ceiling, which some experts consider the least unconstitutional option. +
++Debates about these options often devolve into discussions of legal arcana and political perceptions: would it look bad for Biden to seize more power like this? Would it seem silly to mint a trillion-dollar coin? And while the legal details and the politics matter, I think much of the discussion of these options gives short shrift to their biggest challenge: the bond market. +
++“I used to think if there was reincarnation, I wanted to come back as the president or the pope or a .400 baseball hitter,” the political consultant James Carville once quipped. “But now I want to come back as the bond market. You can intimidate everybody.” +
++Bond traders obviously love that quote, but it’s not just gas for their egos. Modern governments rely on international bond markets to finance themselves, and while those governments’ control over their currencies gives them some protection from the vicissitudes of the markets, this power is hardly absolute. History is littered with cases of governments forced to abandon policies because of bond market revolts. Just a few months ago, a mass selloff by currency and bond traders forced the Tory government in the UK to abandon its plans for a massive deficit-ballooning tax cut and axe Chancellor of the Exchequer Kwame Kwarteng, before Prime Minister Liz Truss herself was forced to resign after just 45 days in office. Banks like Citigroup were openly declaring that unless the UK got a different prime minister, the markets would continue to punish it. +
++We know how bond markets respond to routine increases in the debt ceiling that are not attached to any other policies: they don’t at all. At first glance, the debate around the October and December 2021 debt ceiling increases, which were contested but not in much doubt given Democratic control of Congress, didn’t cause any major changes to the interest investors demanded on short, medium, and long-run Treasury bonds. Yields on those bonds didn’t spike as that debate progressed. +
++We also know how bond markets respond to actually dangerous debt ceiling standoffs, even if they ultimately result in the ceiling being increased. The Government Accountability Office estimated that the 2011 fight, which came really close to disaster, raised interest rates by enough to cost the Treasury $1.3 billion in 2011. That’s not nothing, but it’s pretty tiny in the scheme of the federal budget. By far the largest costs of that showdown were the budget cuts enacted in the deal Boehner and Obama cut. +
++What we don’t know is how the bond markets will respond to Biden making the debt ceiling history, whether through a platinum coin, or invoking the 14th Amendment, or some other means. I certainly don’t know, but people far more expert than me don’t know either. “I would stick with the answer, ‘I don’t know,’” Shai Akabas, director of economic policy at the Bipartisan Policy Center and an expert on the debt ceiling, told me. Unpredictable market reaction, he said, “has been my biggest concern about all these approaches, not that the substance would create some major economic disruption itself.” +
++David Kamin, an NYU law professor and former senior economic adviser to Biden, has said the same: if Biden declares he’s ignoring the debt ceiling, “Republicans will surely scream that he is acting illegally and that the debt issued over the limit is invalid. … it’s imaginable that the market could react badly — and shoot up interest rates on Treasuries.” Minting the coin could have the same result. Kamin isn’t saying this will happen: just that we’re in truly uncharted territory and it might happen. +
++If that just means the inflation-adjusted interest on five-year Treasury bonds goes from, say, 1.42 percent to 1.75 percent (to use the GAO’s higher-end estimate of what happened in 2011) … honestly, that seems fine. It’s not great but it would be a small price to pay for ending the debt ceiling. +
++But the freakout would be longer than in 2011. The matter would go to the courts. Some lower courts would likely rule against the Biden administration, which would spook markets more. The Supreme Court might ultimately rule against the administration, suggesting that its bond payments since it declared it would ignore the debt ceiling were illegal. That could push interest rates really, really high, as investors realize some of the bonds they own might have been illegally issued and perhaps not pay out. +
++And not just on government debt! Economist Filippo Gori has looked at how the 2011 crisis affected the cost of loans not just for the government, but for banks. He found that about half of the increased borrowing costs were passed along to banks. And if bank interest rates rise, then everyone’s interest rates rise. Other businesses borrow their money from banks, and banks will only lend them money if it’s profitable, which means the banks have to charge more than they themselves paid to borrow the money they’re lending out. So all of a sudden everyone’s interest rates are increasing. The Federal Reserve sometimes increases interest rates (as it has in recent months) specifically in order to get people to spend less money and slow down the economy. A debt ceiling crisis could have a similar effect, and potentially a bigger one. It’s easy to imagine this resulting in a full-scale recession. +
++This is not a problem unique to ideas like the 14th Amendment option or minting the coin. If the US were to hit the debt ceiling and the Treasury chose (as it was prepared to in the Obama years) to “prioritize” payments, paying interest on debt and a few select government programs but otherwise skipping out on trillions in government bills, bond markets would almost certainly go nuts. If the Treasury stopped paying interest on debt, and defaulted, that would be as bad or worse. Compared to those options, basically anything from minting the coin to issuing new kinds of debt is far, far preferable. +
++I also think these are risks worth taking relative to the option of making spending concessions to House Republicans. The trillion-plus dollars of spending cuts enacted in 2011 were harmful. They hurt millions of real people deeply. They undermined our ability to prepare for pandemics, right before we experienced the worst pandemic in a century. Worst of all, they taught congressional Republicans that they could take the debt ceiling hostage and extract big concessions, a lesson they are taking to heart now. The only way to break that precedent and prevent the ceiling from being used as a hostage for decades to come is for the debt ceiling to end — by legislation if possible, by fiat if necessary. You have to shoot the hostage. +
++But I think it behooves supporters of these options, like myself, to think more seriously about how to answer the challenge of the bond market. I can imagine Biden and his advisers making a choice between a deal with McCarthy and something like minting the coin, and defaulting to the former because there’s less bond market risk, and thus less risk of crisis and recession, involved. I think they’d be wrong, but it really is true that making a spending deal would have more predictable consequences in this regard. The 2011 deal did considerable harm but did not result in a recession, which would have been even worse. +
++Convincing the administration to take another path requires figuring out some way to reassure markets in the aftermath of Biden nullifying the debt ceiling, and to prevent the legal risk inherent in that measure from wreaking economic calamity. I don’t know how to do that myself; if I did, I’d say something. But luckily there are many people who know these markets better than I do who are hopefully working on ways to make this option more attractive to the administration. If Biden isn’t persuaded, we could be in for another decade of spending retrenchment and a lifetime of debt ceiling crises to come. +
World Cup Hockey: Australia mauls South Africa, qualifies directly for quarterfinals - Australia will face the winner of the crossover match between Malaysia and Spain in the quarterfinal match on January 24
Siege Courageous, Disruptor, Only You, Maroon, Del Pico and Always Happy excel -
Indian Olympic Association calls emergency Executive Council meeting to discuss protesting wrestlers’ demands - The meeting, which has been called after protesting wrestlers wrote to IOA chief P.T. Usha, will take place at 5.45 p.m. today (January 20)
Reid not satisfied with his boys’ show against Wales, but hopes to build on their fighting spirit - India was expected to go on a goal spree as the situation demanded, but seemed to be bothered by the pressure of having to score big
Hockey World Cup | Hit as a skill slowly going extinct, need it for both scoring and variety: Floris Jan Bovelander - The Dutch great lists his team among the favourites to win alongside Australia
Disaster preparedness measures reviewed in the Nilgiris -
Here are the big stories from Tamil Nadu today -
Kamareddy Municipal Council passes unanimous resolution cancelling draft Master Plan - Master plan submitted by the Council was modified by officials at the State-level, says Chairperson; New Master Plan will be drawn up, says Arvind Kumar
Chief of Air Staff visits SAC HQ -
Karnataka Assembly elections is battle between ideals of Gandhi and Godse, says Congress leader B.K. Hariprasad - Leader of the Opposition in the Legislative Council B.K. Hariprasad accuses Prime Minister Narendra Modi of ‘political tourism’ in Karnataka ahead of Assembly elections
Ukraine war: Give us tanks, says Zelensky, as Western allies meet - Ukraine’s leader calls on the West to hand over Leopard tanks as dozens of countries hold crunch talks.
Romania court extends Andrew Tate police detention - Influencer Andrew Tate will stay in custody until 27 February after a Romanian court extends his detention.
Ukraine war: Serbia uproar over Wagner mercenaries recruiting for Russia - A Russian news video showing Serbians being trained to fight in Ukraine prompts fury in Belgrade.
Tanzanian killed in Ukraine: We told him not to go - Nemes Tarimo, who was in prison in Russia, joined the Wagner Group to get a pardon, his family says.
Ireland leader Leo Varadkar says he has regrets over NI Protocol - The Taoiseach says the post-Brexit measure was imposed on unionists and nationalists without their consent.
Rocket Report: SpaceX reaches ‘ludicrous’ cadence; ABL explains RS1 failure - “This evidence suggests that an unwanted fire spread to our avionics system.” - link
Pioneering Apple Lisa goes “open source” thanks to Computer History Museum - Lisa OS 3.1’s 1984 source Pascal code now available under a non-commercial license. - link
Hacker group incorporates DNS hijacking into its malicious website campaign - The DNS hijacking threat can be especially high for people using public Wi-Fi. - link
Meet the real zombifying fungus behind the fictional Last of Us outbreak - Ants are in trouble, but humans are safe… for now. - link
Winnebago’s first electric motorhome prototype breaks cover - One battery for the powertrain, another for the house functions and rooftop solar. - link
I stand behind Alec Baldwin -
++It’s far safer than standing in front of him. +
+ submitted by /u/JackdawMiles
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I didn’t know r/Jokes was so eco friendly -
++Everything here is recycled. +
+ submitted by /u/vintagevz
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My grandma is 80% Irish. -
++Her name is Iris. +
+ submitted by /u/StuntNun
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How do you follow Will Smith in a snow storm? -
++You follow the fresh prints. +
+ submitted by /u/jdusher
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A man was having a pee at a urinal in Jamaica when a local man joined him.. -
++“What is that tattoo you have on your penis?” Says the local man +
++“Oh, it says WY now because it was the name of my ex girlfriend, Wendy, so when I get an erection it says her name..” says the man. +
++“Take a look at this” the Jamaican shows the man his penis, also having WY on his penis.. +
++“Is your ex girlfriend called Wendy too?” +
++The local man laughs, “no, when I get an erection mine says, Welcome to Jamaica, I hope you enjoy your stay!” +
+ submitted by /u/CoreyReynolds
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