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+ + + +Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE) - Conditions: Advanced Respiratory Disease; Chronic Breathlessness Due to Advanced Respiratory Disease; Chronic Obstructive Pulmonary Disease; Bronchiectasis; Interstitial Lung Disease; Lung Cancer; Asthma; Chronic Fibrotic Lung Disease Following SARS-CoV2 Infection
Interventions: Other: SELF-BREATHE
Sponsors: Kingâs College Hospital NHS Trust
Not yet recruiting
Valacyclovir Plus Celecoxib for Post-Acute Sequelae of SARS-CoV-2 - Conditions: Long COVID; PASC Post Acute Sequelae of COVID 19
Interventions: Drug: Valacyclovir celecoxib dose 1; Drug: Valacyclovir celecoxib dose 2; Drug: Placebo
Sponsors: Bateman Horne Center
Recruiting
Supervised Computerized Active Program for People With Post-COVID Syndrome (SuperCAP Study) - Conditions: Post-COVID Condition
Interventions: Device: SuperCAP Program
Sponsors: FundaciĂłn FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la PromociĂłn de la Salud y la Ciencia; Institut de Recerca de la SIDA IrsiCaixa; Germans Trias i Pujol Hospital
Recruiting
Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19 - Conditions: Long COVID
Interventions: Diagnostic Test: RNA Biomarker Blood Test
Sponsors: MaxWell Clinic, PLC
Recruiting
Home-Based Circuit Training in Overweight/Obese Older Adult Patients With Knee Osteoarthritis and Type 2 Diabetes - Conditions: Aerobic Exercise; Strength Training; Glycemic Control; Blood Pressure; Oxidative Stress; Metabolic Syndrome
Interventions: Behavioral: 12-week home-based circuit training (HBCT); Behavioral: Standard of care (CONT)
Sponsors: Princess Nourah Bint Abdulrahman University
Completed
SVF for Treating Pulmonary Fibrosis Post COVID-19 - Conditions: Pulmonary Fibrosis
Interventions: Biological: Autologous adipose-derived SVF IV administration
Sponsors: Michael H Carstens; Ministerio de Salud de Nicaragua; Wake Forest University; National Autonomous University of Nicaragua
Completed
RECOVER-AUTONOMIC Platform Protocol - Conditions: Long COVID; Long Covid19; Long Covid-19
Interventions: Drug: IVIG + Coordinated Care; Drug: IVIG Placebo + Coordinated Care; Drug: Ivabradine + Coordinated Care; Drug: Ivabradine Placebo + Coordinated Care; Drug: IVIG + Usual Care; Drug: IVIG Placebo + Usual Care; Drug: Ivabradine + Usual Care; Drug: Ivabradine Placebo + Usual Care
Sponsors: Kanecia Obie Zimmerman
Enrolling by invitation
RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine) - Conditions: Long COVID; Long Covid19; Long Covid-19
Interventions: Drug: Ivabradine; Drug: Ivabradine Placebo; Behavioral: Coordinated Care; Behavioral: Usual Care
Sponsors: Kanecia Obie Zimmerman
Enrolling by invitation
RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG) - Conditions: Long COVID; Long Coronavirus Disease 2019 (Covid19); Long Covid-19
Interventions: Drug: IVIG (intravenous immunoglobulin); Drug: IVIG Placebo; Behavioral: Coordinated Care; Behavioral: Usual Care
Sponsors: Kanecia Obie Zimmerman
Enrolling by invitation
Establishment, Optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting Cathepsin L inhibitors - Cathepsin L (CTSL), a lysosomal cysteine proteinase, is primarily dedicated to the metabolic turnover of intracellular proteins. It is involved in various physiological processes and contributes to pathological conditions such as viral infection, tumor invasion and metastasis, inflammatory status, atherosclerosis, renal disease, diabetes, bone diseases, and other ailments. The coronavirus disease 2019 (COVID-19), with its rapid global spread and significant mortality, has been a worldwideâŠ
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire - Antigenic drift, the gradual accumulation of amino acid substitutions in the influenza virus hemagglutinin (HA) receptor protein, enables viral immune evasion. Antibodies (Abs) specific for the drift-resistant HA stem region are a promising universal influenza vaccine target. Although anti-stem Abs are not believed to block viral attachment, here we show that complement component 1q (C1q), a 460-kilodalton protein with six Ab Fc-binding domains, confers attachment inhibition to anti-stem Abs andâŠ
Molecular docking and molecular dynamic simulation-based phytoconstituents against SARS-CoV-2 with dual inhibition of the primary protease targets - A novel coronavirus has caused major health problems and is spreading globally. The main protease enzyme plays a significant role in the number of copies of ss-RNA produced during the proteolytic cleavage of polypeptides. This work aims to find possible dual inhibitors of the 3-Chymotrypsin-like proteases PDB-6W63 and 6LU7 which increase efficiency and faster inhibition activity. By using an in-silico technique, polyphenols are molecularly docked against these targets to inhibit proteaseâŠ
N-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2 - RNA cap methylations have been shown to be crucial for the life cycle, replication, and infection of ssRNA viruses, as well as for evading the hostâs innate immune system. Viral methyltransferases (MTases) therefore represent an attractive target for the development of compounds as tools and inhibitors. In coronaviruses, N7-methyltransferase function is localized in nsp14, which has become an increasingly important therapeutic target with the COVID-19 pandemic. In recent years, we have beenâŠ
Unusual NiNi interaction in Ni(ii) complexes as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron drugs - Two nickel(ii) coordination complexes Ni(L)(1) and Ni(L)(2) of a tetradentate Schiff base ligand (H(2)L) derived from 2-hydroxy-1-naphthaldehyde with ethylenediamine were synthesized, designed, and characterized via spectroscopic and single crystal XRD analyses. Both nickel(ii) complexes exhibited unusual NiâŻNi interactions and were fully characterized via single-crystal X-ray crystallography. Nickel(ii) complexes Ni(L)(1) and Ni(L)(2) crystallize in monoclinic and triclinicâŠ
Integrating virtual screening, pharmacoinformatics profiling, and molecular dynamics: identification of promising inhibitors targeting 3CLpro of SARS-CoV-2 - Introduction: The pursuit of effective therapeutic solutions for SARS-CoV-2 infections and COVID-19 necessitates the repurposing of existing compounds. This study focuses on the detailed examination of the central protease, 3-chymotrypsin-like protease (3CLpro), a pivotal player in virus replication. The combined approach of molecular dynamics simulations and virtual screening is employed to identify potential inhibitors targeting 3CLpro. Methods: A comprehensive virtual screening of 7120âŠ
TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes - The Nucleocapsid Protein (NP) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not only the core structural protein required for viral packaging, but also participates in the regulation of viral replication, and its post-translational modifications such as phosphorylation have been shown to be an important strategy for regulating virus proliferation. Our previous work identified NP could be ubiquitinated, as confirmed by two independent studies. But the function of NPâŠ
Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality - The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infection. To test this hypothesis, we developed a novel mouse-adapted SARS-CoV-2 model (MA20) that recapitulates key pathological features of COVID-19âŠ.
No immunological interference or concerns about safety when seasonal quadrivalent influenza vaccine is co-administered with a COVID-19 mRNA-1273 booster vaccine in adults: A randomized trial - The objective of the study was to assess the safety and immunogenicity of mRNA-1273 COVID-19 booster vaccination when co-administered with an egg-based standard dose seasonal quadrivalent influenza vaccine (QIV). This was a phase 3, randomized, open-label study. Eligible adults aged â„ 18 years were randomly assigned (1:1) to receive mRNA-1273 (50 ”g) booster vaccination and QIV 2 weeks apart (Seq group) or concomitantly (Coad group). Primary objectives were non-inferiority of haemagglutininâŠ
Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation - Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral membrane proteins. There are compelling reasons to want to inhibit the activity of individual zDHHC-PATs in both the laboratory and the clinic, but the specificity of existing tools is poor. Given the extensive conservation of the zDHHC-PAT activeâŠ
Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro - Papain-like protease (PLpro) enzyme plays a vital role in viral replication as it breaks down polyproteins and disrupts the hostâs immune response. There are few reports on Kampo formulas that focus on PLpro activity. In this study, we evaluated the inhibitory effects of senkyuchachosan, a traditional Japanese medicine, on PLpro of SARS-CoV-2, the virus responsible for causing COVID-19. We purified the PLpro enzyme and conducted in vitro enzymatic assays using specific substrates. Among the nineâŠ
Identification of inositol monophosphatase as a broad-spectrum antiviral target of ivermectin - Ivermectin has broad-spectrum antiviral activities. Despite the failure in clinical application of COVID-19, it can serve as a lead compound for the development of more effective broad-spectrum antivirals, for which a better understanding of its antiviral mechanisms is essential. We thus searched for potential novel targets of ivermectin in host cells by label-free thermal proteomic profiling using Huh-7 cells. Inositol monophosphatase (IMPase) was found among the proteins with shifted thermalâŠ
Optimized Recombinant Expression and Purification of the SARS-CoV-2 Polymerase Complex - An optimized protocol has been developed to express and purify the core RNA-dependent RNA polymerase (RdRP) complex from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The expression and purification of active core SARS-CoV-2 RdRp complex is challenging due to the complex multidomain fold of nsp12, and the assembly of the multimeric complex involving nsp7, nsp8, and nsp12. Our approach adapts a previously published method to express the core SARS-CoV-2 RdRP complex inâŠ
Supporting underrepresented students in health sciences: a fuzzy cognitive mapping approach to program evaluation - CONCLUSIONS: The findings from a multipronged analysis of mapping data demonstrate the value of this innovative approach to the field, especially when looking to incorporate student voices.
An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting Mpro - Coronaviruses (CoVs) are responsible for a wide range of illnesses in both animals and human. The main protease (M^(pro)) of CoVs is an attractive drug target, owing its critical and highly conserved role in viral replication. Here, we developed and refined an enzymatic technique to identify putative M^(pro) inhibitors from 189 marine chemicals and 46 terrestrial natural products. The IC(50) values of Polycarpine (1a), a marine natural substance we studied and synthesized, are 30.0 ± 2.5 nM forâŠ
What It Takes to Give Palestinians a Voice - A new poll conducted during war in Gaza and escalating tensions in the West Bank allows Palestinians to tell the world what they want for their future. - link
The Crime Rings Stealing Everything from Purses to Power Tools - In Los Angeles, a task force of detectives is battling organized retail theft, in which boosted goods often end up for sale onlineâor commingled on store shelves with legitimate items. - link
How Quinta Brunson Hacked the Sitcom with âAbbott Elementaryâ - With âAbbott Elementary,â the comedian and writer found fresh humor and mass appeal in a world she knew well. - link
How Julienâs Auctions Leads the Booming Market in Celebrity Memorabilia - As the art market cools, Julienâs Auctions earns millions selling celebrity ephemeraâand used its connections to help Kim Kardashian borrow Marilyn Monroeâs J.F.K.-birthday dress. - link
Has Putinâs Invasion of Ukraine Improved His Standing in Russia? - As Russians go to the polls, the economy is booming and the public feels hopeful about the future. But the politics of Putinism still depend on the absence of any means to challenge it. - link
+How come thereâs never been an Asian Bachelorette? +
++For the first time in years, The Bachelor franchise had not one, not two, but multiple contestants of Asian descent who were prominent contenders. +
++Historically, there have been a handful of Asian participants who have made it to later rounds in the show. But in most seasons, there are few â if any â Asian contestants across both The Bachelor and Bachelorette. Those who are cast are often eliminated early, sidelined as supporting characters, or reduced to meek stereotypes. Tammy Ly, a fan favorite from the 24th season, has spoken about how she felt âalienatedâ by the franchise and treated as a secondary character because she didnât fit a white ideal of beauty. +
++The Bachelor franchise has long been critiqued for its overwhelmingly white casting, storylines that amplify discriminatory tropes, and high-profile contestants whoâve made racist statements. In recent seasons, the show has attempted to address these disparities â with mixed results. Notably, ABC cast its first Black Bachelorette, Rachel Lindsay, in 2017, and it has sought to diversify its contestant pool in the years since. As Rachel Lindsay and other contestants have emphasized, however, the changes to casting alone havenât been sufficient to combat systemic issues the franchise suffers from, onscreen and behind the scenes. +
++The most recent season, its 28th, revealed how The Bachelor still struggles with many of these problems even as it took some small steps forward. In showcasing a diverse group of Asian women, the show introduced new perspectives on everything from growing up in an immigrant household to cultural family traditions, viewpoints that havenât been highlighted much on its platform. It still fell short, however, in grappling with the discrimination that its contestants of color face and confronting conversations about the need to explicitly call out racism. +
++Five women of Asian descent stayed late into the current season as both popular contenders and villains. Notably, a few of these women â Rachel Nance, an ICU nurse from Hawaii, of Filipino and African American descent; and Jenn Tran, a physicianâs assistant student from Florida, of Vietnamese descent â were among the final six contestants, a development that makes it more likely that one of them could get picked as the lead for a following season. (Typically, the show selects its next star based on the women or men who donât âwinâ from the prior season.) +
++Featuring more Asian contestants on the show â and highlighting them â has not only helped dispel stereotypes, but also enabled portrayals that were more multidimensional and human. Having an Asian lead â a long overdue first for both The Bachelor and The Bachelorette â would bring even more representation to the reality TV giant, expand the universe of stories that it tells, and provide new visibility to members of a group that have long been underrepresented in media. +
++The Bachelor franchiseâs history of quickly dropping candidates of color, including Asian contestants, is so well-known it has spurred satirical spinoffs like WongFu Productionâs âAsian Bachelorette,â in which nearly all the contestants are of Asian descent. +
++In past seasons, there were usually one or two Asian contestants, though few advanced to later episodes, with Catherine Giudici, Ivan Hall, Caila Quinn, Ethan Kang and Serena Pitt among the handful of exceptions. +
++Additionally, if they arenât eliminated early, contestants of color typically get less screen time than white contestants. And when they have appeared, some of their storylines have exacerbated old tropes, including ideas of Asian women as docile or hypersexual. +
++In season 24 of The Bachelor, for example, Marylynn Sienna is effectively used by a white woman named Victoria Larson to advance her storyline. Larson arbitrarily accuses Marylynn of being âtoxic,â forcing her to defend herself in the face of a bully. In Season 10 of The Bachelor, a Cambodian American woman named Channy Choch debuted on the show by inviting the lead to have sex with her in Cambodian, later noting that he needed to catch âCambodian fever.â +
++By putting real time and investment into Asian contestantsâ storylines, this season has delivered more nuanced depictions of their experiences and the chance to see more humanized narratives. +
++Rachelâs hometown date with Bachelor Joey Graziadei, a milestone that takes place near the end of the season when the lead meets a contestantâs family, was a vibrant glimpse of how Filipino and Hawaiian culture have shaped her. Prior to the visit, Rachel informs Joey that he should touch her motherâs hand to his forehead when they meet, a gesture known as âMano po,â which conveys respect. And during the date, Rachelâs family warmly receives him with a roast pig in the backyard and schools him on a Filipino courtship tradition. +
++++@bachelornationabc + ++Joey with the Mano Po +
+⏠original sound - The Bachelor +
+Rachel has also discussed her upbringing in Hawaii as a mixed-race person, offering a perspective thatâs rarely been highlighted on the show, and emphasizing how her family has blended different cultures. âGrowing up as a mixed girl in Hawaii, there wasnât many people who looked like me on TV,â she said in a People interview. âIâm very honored that moving forward, girls can say, âHey, if Rachel can do that, I can do that. If Rachel can speak her truth, I can speak her truth.ââ +
++Another moving moment this season centered on Jenn and her description of the trauma she experienced growing up in a dysfunctional household. In one scene, Jenn spoke candidly about the conflict in her immigrant family, prompting what sheâs said has been an outpouring from fans who have similar backgrounds. While on a one-on-one date with Joey, Jenn described how her parents often had volatile fights when she was a kid and how her relationship with her father has deteriorated in the years since as a result. +
++âI wanna acknowledge the comments and DMs Iâve been getting from people who say that they can relate to my story and I just want to say that Iâm so sorry you can relate,â Jenn said in a TikTok post. âIt felt so nice to hear another Viet woman go through the same generational trauma that I went through,â one of the top commenters on the post wrote. +
++++@jenntranx + ++Toxic relationships is something i really want to talk about bc often times we dont know weâre in one bc it creeps up on you but i want everyone to know theyre deserving of love and to not let history repeat itself #toxic #toxicrelationship #emotionalabuse #abuse #relationships #relationshipadvice +
+⏠original sound - Jenn Tran +
+Both Nance and Tran also received âhot seats,â or special interviews, in the recent âWomen Tell Allâ episode, often a sign ABC is considering them as potential leads. Nance was known on the show for her level-headed energy, commitment to her career, and âslow burnâ relationship with Joey, while Tranâs bubbly personality, openness to adventure, and a playful connection were her signature. Both women, who were eliminated in recent weeks, were charismatic contenders and would be compelling future stars. +
++Being able to see an array of Asian women depicted this season was significant as well because it highlighted a wide spectrum of personalities. In addition to Rachel and Jenn, who were portrayed more prominently as frontrunners focused on vying for Joeyâs affections, Katelyn DeBacker, a radiochemist from New Mexico of Vietnamese descent, was seen as bringing her quirk and humor to the show, and Madina Alam, a therapist of Bangladeshi descent, was synonymous with her thoughtful and considerate responses to the bizarre drama swirling around her. Lea Cayanan, an account manager from Hawaii who is of Filipino descent, also received what is known in Bachelor parlance as a âvillain edit,â in a way barrier-breaking in itself. +
++After dueling with fellow contestant Maria Georgas â a white executive assistant from Ontario, Canada â Lea became associated with causing drama and coming off as a âmean girl.â While her actions were far from laudable, it was interesting to see an Asian woman embrace the role of the villain after years of other portrayals as submissive sidekicks. That said, when you distill that storyline to its essence, she was still used to draw a contrast with a white counterpart, a problematic plot point of its own. +
++Itâs uncommon to see Asian women depicted in pop culture in a way thatâs more complicated and messy, NPRâs Deepa Shivaram previously wrote about Devi, the protagonist of the Netflix show Never Have I Ever. +
++Harleen Singh, director of the Womenâs Studies Research Center at Brandeis University, emphasized that representation and the breaking of stereotypes require the chance for people to be their full selves and not just an ideal thatâs been set out for them. âItâs ⊠[the ability] to just be human beings who have errors, who have wants, who are contradictory. Pardon my French, but to f*** up as much as anybody else,â Singh previously told NPR. +
++Asian contestants have also used their platforms to force conversations about racism that would otherwise be left poorly addressed by a franchise ill-equipped to confront them. +
++One of the early examples of this was tied to a mistake that The Bachelorâs social media accounts made in January, when it tagged the wrong Asian person in an Instagram post. In a photo of Jenn kissing Joey, The Bachelor account instead tagged Lea. That mistake then sparked a discussion about how Asian people have been confused for one another in different settings, including the workplace, and how dehumanizing those errors can be. +
++In response to the mix-up, Jenn posted a TikTok video sharing an experience of how a nurse she worked with wasnât able to tell her apart from another Asian staff member, despite having known each other for a year. âThe issue at hand is not that you canât tell me apart from different Asians, itâs the fact that you donât care,â Jenn said in the video. +
++++@jenntranx + ++This is why Asian representation on TV is so important. The lack of exposure directly correlates to the ignorance. Iâm not saying everyone is guilty of cultural ignorance but it is disheartening to see how many news articles about me have used pictures of other Asian women who clearly do not look like me. Letâs continue to take accountability, learn from others and lead with love always #culturalignorance #diversity #asianamerican #asian #culture #vietnamese +
+⏠original sound - Jenn Tran +
+Itâs a problem thatâs so commonplace that designer Linh-Yen Hoang has released a pithy pin that simply reads, âWrong Asian.â And while people often brush off such actions as honest mistakes, they essentially suggest that Asian people are interchangeable, reaffirming tropes that Asian people are a monolithic group devoid of individuality. +
++âWhether the person acted without malice, the effect is the same: It erases my body of work for someone elseâs, simply because their ancestors were born on the same continent as mine,â Washington Post reporter Michelle Ye Hee Lee wrote in 2019. âIt tells me that my place in journalism â and that of the other Asian reporter they confused me for â is dispensable, interchangeable and indistinguishable.â +
++Jennâs and Leaâs perspectives were ultimately invaluable in having a deeper conversation about this mishap and in drawing attention to a widespread issue that some may write off as trivial. âUntil we have a world stage and a media platform that is representative of the world we come from and the communities that make it up, I think we will always have a ways to go,â Lea stated in her response. +
++During the âWomen Tell Allâ episode, Rachel also spoke about racism sheâs faced from viewers of the show, revealing that people have bombarded her with messages calling her the âN-wordâ and âjungle Asian.â Many of these attacks came after Rachel was chosen to move forward as one of the final three contestants instead of Maria, who has accrued a large fanbase. +
++Rachelâs comments have renewed attention to the racism within the Bachelor fandom and the harassment that contestants of color, in particular, have faced. +
++That conversation showed, too, how much work the show still needs to do to protect its contestants and to thoughtfully handle the subject. Rather than specifically addressing the racism that Rachel experienced, for instance, host Jesse Palmer quickly pivoted to asking the rest of the cast if they had received âhatefulâ comments in a follow-up to her remarks. In doing so, he glossed over the specific racism she was experiencing and sought to broaden the focus to more general harassment that the cast of women has faced. +
++âIt is part of my Asian culture to remain quiet, always be respectful, and apologize first. No more,â Rachel wrote in an Instagram post. â It is time that we speak up. To all my minorities⊠speak up and speak loud.â +
++Whether itâs offering viewers a window into their personalities and upbringings, or vocally condemning enduring racism in the franchise, the contestants of this season have brought new voices to a tired show. Leads on the show, in particular, also send a message about who has agency in these relationships, and whoâs deserving of this chance to find love. Casting Rachel or Jenn as the next Bachelorette would be a huge opportunity to keep these conversations going â and reframe that narrative. +
++Roughly 80 percent of House Republicans just lined up behind a plan to cut Social Security and ban all abortions. +
++Donald Trump would be on track to win a historic landslide in November â if so many US voters didnât find him personally repugnant. +
++Roughly 53 percent of Americans have an unfavorable opinion of the former president. And yet, when asked about Trumpâs ability to handle key issues â or the impact of his policies â voters routinely give the Republican candidate higher marks than President Biden. +
++In a YouGov survey released this month, Trump boasted an advantage over Biden on 10 of the 15 issues polled. On the three issues that voters routinely name as top priorities â the economy, immigration, and inflation â respondents said that Trump would do a better job by double-digit margins. +
++Meanwhile, in a recent New York Times/Siena College poll, 40 percent of voters said that Trumpâs policies had helped them personally, while just 18 percent said the same of Biden. If Americans could elect a normal human being with Trumpâs reputation for being âtoughâ on immigration and good at economics, they would almost certainly do so. +
++Biden is fortunate that voters do not have that option. But to erase Trumpâs small but stubborn lead in the polls, the president needs to erode his GOP rivalâs advantage on the issues. +
++Bidenâs approach to that task has long been clear: He wants to make voters more concerned about two policy areas where Democrats still have the upper hand â Social Security and abortion â while making them more aware of the GOPâs extremely unpopular positions on those issues. +
++Trump has tried to mitigate his vulnerability on these fronts by insisting that he opposes Social Security cuts (occasional off-the-cuff comments to the contrary notwithstanding) and endorsing a ban on abortions after 15 weeks of pregnancy, instead of the blanket ban on all abortions that the Christian right favors. +
++Congressional Republicans have aided this effort by distancing themselves from their historic support of entitlement cuts during last yearâs debt ceiling standoff. More recently, they tried to dissociate their party from the most unpopular aspects of the anti-abortion movementâs agenda, voicing opposition to the shutdown of in vitro fertilization clinics in Alabama. +
++But this week, the House GOP let the mask slip. +
++On Wednesday, the Republican Study Committee (RSC) â a caucus that represents 80 percent of House Republicans, including the partyâs entire leadership â unveiled a budget that calls for cutting Social Security benefits and establishing that human life begins at conception. +
++The RSC tried to obscure the implications of its Social Security policy by describing its proposal as an increase in âthe retirement age,â and declining to specify what the new age should be. +
++But that is just an opaque way of describing a large cut in benefits. As Matt Bruenig notes, Social Security does not have a single retirement age: It has 96 different retirement ages, each associated with a different level of benefits. +
++When lawmakers talk about âraising the retirement age,â they are really calling for an increase in the âfull retirement ageâ â a variable in a formula that determines benefit levels at all 96 retirement ages. Raising the full retirement age to 69 â as the RSC proposed last fall â would translate into a roughly 14 percent cut to Social Security benefits, according to the Center on Budget and Policy Priorities. +
++The RSCâs proposal would not impact existing beneficiaries, but those retiring as soon as 2033 would have to get by on lower monthly incomes. +
++The RSC budget falsely suggests that its reforms would leave future retirees better off than Bidenâs entitlement policies would. The caucus notes that, absent policy change, Social Securityâs trust fund will become insolvent by 2033, a development that would trigger a 23 percent cut to benefits, and it claims that simply letting Social Security go bankrupt is Bidenâs actual plan. +
++But this is a description of Trumpâs position, not the presidentâs. The likely GOP nominee has offered no explanation for how he would keep Social Security funded. To the contrary, he has signaled plans for slashing federal tax revenues by trillions of dollars, policies that would make preserving existing benefit levels even more fiscally challenging. +
++Biden, on the other hand, has called for substantially raising payroll taxes on Americans earning over $400,000 a year in order to sustain Social Security in its current form. +
++It is true that this by itself would not be enough to preserve benefits indefinitely; as boomers continue retiring and Americaâs ratio of retirees-to-workers rises, larger tax increases would be required to sustain todayâs benefit levels through the 2040s. But there is a simple way to alleviate this problem: We could allow more prime-age adults to come to the United States and contribute to its economy. Alas, Trump and his party would like to do the opposite. +
++In any case, the RSCâs budget clarifies the partiesâ respective positions on Social Security: Biden wants to preserve existing benefits through higher taxes on the rich, most House Republicans want to cut future benefits by 14 percent, and Trump wants to avoid taking any coherent position while starving the government of revenue, thereby engineering a 23 percent benefit cut by default. +
++Meanwhile, the RSCâs budget also calls for the passage of the Life at Conception Act, which would establish that âthe right to life guaranteed by the Constitution is vested in each human being at all stages of life, including the moment of fertilization.â This would make abortion illegal in all cases, including for patients who were impregnated through rape or incest. Whatâs more, the budget would also cut Medicaid, the Affordable Care Act, and the Childrenâs Health Insurance Program by $4.5 trillion over 10 years, a proposal that might increase the salience of health care policy, which remains a source of Democratic strength. +
++Democrats didnât wait long before unwrapping this political gift. Biden decried the RSC budget as âextremeâ Thursday, noting that it âshows what Republicans value.â The White House then circulated a rundown of the planâs most unpopular provisions while Senate Majority Leader Chuck Schumer denounced it from the Senate floor. +
++Itâs unlikely that any of this will make a big impression on undecided voters, who do not typically pay much attention to budget proposals in general, let alone those without a prayer of actually passing in the current Congress. But the Biden campaign will be able to draw on the RSCâs proposals in future campaign advertisements. +
++Itâs unclear whether this will be enough to dissuade voters of the view that Donald Trump is a bad man with good policies. But right now, Biden can use all the help he can get. And House Republicans just made an in-kind contribution to his campaign. +
+Itâs not just the Princess of Wales. More and more young people are getting cancer. +
++Kate Middleton, now Catherine, Princess of Wales, announced Friday in a video message that she was diagnosed with cancer after doctors performed abdominal surgery on her earlier this year and discovered evidence of the disease. +
++Kensington Palace did not release details on what type of cancer the princess has, nor did it specify what stage the cancer is or her possible prognosis. But what we do know is that, as a 42-year-old woman, she is far from alone in her diagnosis: Worldwide, more and more people under 50 are developing cancers. +
++Cancer typically strikes those who are in their 50s, 60s, or even older. Yet, in recent decades, early-onset cancers â which are usually defined as occurring in patients younger than 50 â are occurring at a higher rate, particularly in wealthy countries. As illustrated in the chart below, a 2023 BMJ analysis found that the early onset of 29 different cancers had risen nearly 80 percent globally between 1990 and 2019. +
+ ++
++Separately, a study published in JAMA Network Open the same year concluded that the occurrence of a wide range of cancers among people under 50 had increased between 2010 to 2019 among American adults, particularly among women. +
++Much of the increase is attributable to colon and rectal cancers: In 2019, there were about 5.7 cases of colorectal cancer among 100,000 people ages 14 to 49. Thatâs up 63 percent since 1990, when there were approximately only 3.5 cases per 100,000 people. Breast, cervical, and skin cancers are still the most likely cancers to develop in adults under 50, but individual cases of colorectal cancers taking the lives of well-known celebrities, like actor Chadwick Boseman in 2020, have made that trend more visible in recent years. +
++Cancers of the bladder, kidney, ovaries, pancreas, prostate, thyroid, and uterus also became significantly more common in the nearly three decades covered by the global investigation published in BMJ. +
++John Marshall, director of the Ruesch Center for the Cure of Gastrointestinal Cancers at Georgetown University, told me recently that, early in his career, he rarely saw a patient under 50. Today, half of his patients are in that age range, many of them appearing to be healthy and fit. At first, these young patients usually came in with colorectal cancer, but Marshall has increasingly seen younger people with cancers attacking other parts of the gastrointestinal tract. +
++No single factor is to blame for this widespread uptick in numerous cancers among young people, particularly the rise in the gastrointestinal system, but scientists are starting to put together a picture of the reality behind one of the most important medical mysteries of our time. +
++One review published in Frontiers in Nutrition in 2022 found several dietary factors were associated with early-onset colorectal cancer. Eating a lot of deep-fried and processed foods, foods high in fat, and sugary drinks and desserts was a significant risk factor, as was having a diet low in fiber. Other studies have found higher alcohol consumption is associated with an increased risk of developing cancer early. +
++Toxins in our environment, such as microplastics, could also be a contributing factor. These tiny particles can be found in everything from food containers to synthetic clothing, before making their way into our bodies and our GI tracts. +
++One New Zealand research team concluded the upticks in cancers among young adults matched the timeline that we would expect from the multiplication of microplastics in the environment. Cellular and rodent models have suggested that microplastics could promote tumor growth. Though more research is needed, these materials contain chemicals that can disrupt hormones and pose a risk to our health. +
++But these are still theories. While the mystery behind Catherineâs disappearance from public life these past few months has now been solved, scientists still donât fully understand what is primarily driving earlier-in-life cancer cases. What we do know is that such stories are becoming all too common. +
Arjun and Jeevan in Challenger final -
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IPL-17: PBKS vs DC | Abishek Porelâs blitzkreig takes Delhi to competitive total - The game marks the comeback of Rishabh Pant, who was out of action for more than 14 months after a horrific car accident in December, 2022.
IPL-17: GT vs MI | Pandya begins high-profile Mumbai captaincy stint against Gujarat - Having led Mumbai to as many as five IPL titles, Rohit Sharma will be turning up as a player this season and would be expected to hit top form ahead of the ICC event in June.
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Congress like well-established company with fluctuating market cap; BJP startup, says Jairam Ramesh - The seven-phase Lok Sabha polls will be held between April 19 and June 1. The results will be announced on June 4.
Delhi Excise policy case | Kavithaâs nephew involved in transfer, use of proceeds: ED -
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Moscow attack: âThe first thing you notice is the smellâ - The BBCâs Steve Rosenberg visits the Moscow concert hall where more than 100 were people were killed.
US call at UN for Gaza truce linked to hostages blocked - The draft resolution put to the UN Security Council marked a hardening of its stance towards Israel.
Varadkar denies resignation conspiracy theories - Rumours over why Leo Varadkar decided to resign have persisted since the announcement.
Testing the 2024 BMW M2âmaybe the last M car with a manual transmission - Weâve tested the three-pedal, stickshift BMW M2 on the road and on track. - link
Reddit faces new reality after cashing in on its IPO - Reddit must now answer to its shareholders as well as its vocal users. - link
Dragonâs Dogma 2 is gritty, janky, goofy, tough, and lots of fun - This epic RPG reminds us of Skyrimâs ambitious jank, but with way better combat. - link
Itâs a few years late, but a prototype supersonic airplane has taken flight - âThis milestone will be invaluable to Boomâs revival of supersonic travel.â - link
GM stops sharing driver data with brokers amid backlash - Customers, wittingly or not, had their driving data shared with insurers. - link
A blonde was taking helicopter lessons. The instructor said, âIâll radio you every 1000 feet to see how youâre doing.â -
++At 1000 feet, the instructor radioed her and said she was doing great. At 2000 feet, he said she was still doing well. Right before she got to 3000 feet, the propeller stopped, and she twirled to the ground. The instructor ran to where she crash landed and pulled her out of the helicopter. âWhat went wrong?â The blonde said, âAt 2500 feet, I started to get cold, so I turned the big fan off.â +
+ submitted by /u/YZXFILE
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Three young women are at a cocktail party. -
++The conversation turns to their position in life and itâs clear that they are trying to one-up each other. +
++The first one says, âMy husband is taking me to the French Riviera for two weeks on vacation,â and then looks at the others with a superior demeanor. +
++The second one says, âWell, my husband just bought me a new Mercedes,â and looks about with considerable pride. +
++Number three says, âWell, to be perfectly honest with you, we donât have much money and we donât have any material possessions. However, one thing I can tell you about my husband is that thirteen canaries can stand shoulder to shoulder on his erect penis.â +
++After this, the first one looks shamefaced and says, âGirls, Iâve got a confession to make. I was just trying to impress you. You know that vacation I was telling you about? Well, itâs not to the French Riviera, itâs to my parents house for two weeks.â The second one says, âYour honesty has shamed me. Itâs not a Mercedes, he bought me a Fiat 500.â +
++âWell,â the third one says, âI also have a confession to make, canary number thirteen has to stand on one leg!â +
+ submitted by /u/orgasmic2021
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Cop pulled me over.. -
++I think, Iâm going to lose my drivers license and all just because of a stupid police officer⊠+
++The conversation went like this, when I got pulled over in my car: Officer: âLicense and registration, please, I think you are drunk!â +
++Me: âI assure you, I did not drink anything.â +
++Officer: âOk, letâs do a little test! Imagine driving in the dark on a highway at night, when you see two lights in the distance. What is this?â +
++Me: âA car.â +
++Officer:âOf course! But which one? A Mercedes, an Audi or a Ford?â +
++Me:âI have no idea!â +
++Officer:âSo, youâre drunk.â +
++Me:âBut I didnât drink anything.â +
++Officer:"Okay, one more test â Imagine, you drive in the dark on a highway at night, and there is one light coming at you.What is it? +
++Me:âA motorcycle.â +
++Officer:âOf course! But which one? A Honda, a Kawasaki or a Harley?â +
++Me:âI have no idea!â +
++Officer:âAs I suspected, youâre drunk!â +
++Then I started to get annoyed and asked a counter question. +
++Me:âSoâŠ, counter question â Youâre driving in the dark on a highway at night and see a woman on the roadside. She wears a mini skirt, fishnet stockings, high heeled shoes and only a bra as a top. What is this?â +
++Officer:âA prostitute of course.â +
++Me:âYes, but which one? Your daughter, your wife or your mother?â +
++Things went downhill from there and now I have a court date to attend⊠+
+ submitted by /u/d4rthSp33dios
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Doctor Who has been filmed all over Britain -
++but there is one place that the makers of the show have been adamant that they will never film in. By the sea, there is a lovely city called Brighton, which has two rather prominent piers. And itâs these piers that are the reason the show makers refuse to bring The Doctor there, because as everyone knows, there is nothing a time traveler hates more than a pair oâ docks. +
+ submitted by /u/jimbotherisenclown
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Hitchhiker is searching for a sleeping place -
++A hitchhiker is searching for a sleeping place for the night as he came by a large farm. +
++He went over to the house and knocks on the door as the owner opens. +
++Do you have a place free for me to sleep tonight? Iâm fine with your barn. I have a sleeping bag. I donât need more. +
++Sure I have. But I warn you only once: keep away from my wife and my daughter, or Iâll shoot you without a warning. +
++OK, thatâs fine. +
++Oh and you can do me a favor: My old shoes are pretty dirty. I have to clean them. They are at the door of the barn. Would you just bring them to me? +
++Yeah sure. +
++So the Hitchiker went over to the barn. Right as he stands at the door he sees the very hot Wife and early twentiesâ daughter. +
++He walks over to them and says: +
++Both very upset: You damn liar, he would never ever say this! Just wait we go and ask him. +
++The Hitchhiker replied: Wait, Iâll do it. +
++He turns around right outside the door and loudly shouts: Both of them? +
++The owner replies: Of course both you Idiot! +
+ submitted by /u/PaygonGrim
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