navan
/
Daily-Dose
mirror of https://github.com/navanchauhan/Daily-Dose.git
1
0
Fork 0
Code Issues Projects Releases Wiki Activity

Added daily report

This commit is contained in:
Navan Chauhan 2021-06-22 12:57:15 +00:00
parent 390ff8bd55
commit aa1bb13d15
3 changed files with 581 additions and 2 deletions
Show Stats Download Patch File Download Diff File Expand all files Collapse all files

231
archive-covid-19/22 June, 2021.html Normal file
View File

@ -0,0 +1,231 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>22 June, 2021</title>
<style type="text/css">
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
</style>
<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Integrative analysis of multi-omics reveals gene regulatory networks across brain regions from risk variants to phenotypes of Alzheimer’s disease and Covid-19</strong> -
<div>
Background: Genome-wide association studies have found many genetic risk variants associated with Alzheimer’s disease (AD). However, how these risk variants affect deeper phenotypes such as disease progression and immune response remains elusive. Also, our understanding of cellular and molecular mechanisms from disease risk variants to various phenotypes is still limited. To address these problems, we performed integrative multi-omics analysis from genotype, transcriptomics, and epigenomics for revealing gene regulatory mechanisms from disease variants to AD phenotypes. Method: First, we cluster gene co-expression networks and identify gene modules for various AD phenotypes given population gene expression data. Next, we predict the transcription factors (TFs) that significantly regulate the genes in each module and the AD risk variants (e.g., SNPs) interrupting the TF binding sites on the regulatory elements. Finally, we construct a full gene regulatory network linking SNPs, interrupted TFs, and regulatory elements to target genes for each phenotype. This network thus provides mechanistic insights of gene regulation from disease risk variants to AD phenotypes. Results: We applied our analysis to predict the gene regulatory networks in three major AD-relevant regions: hippocampus, dorsolateral prefrontal cortex (DLPFC), and lateral temporal lobe (LTL). These region networks provide a comprehensive functional genomic map linking AD SNPs to TFs and regulatory elements to target genes for various AD phenotypes. Comparative analyses further revealed cross-region-conserved and region-specific regulatory networks. For instance, AD SNPs rs13404184 and rs61068452 disrupt the bindings of TF SPI1 that regulates AD gene INPP5D in the hippocampus and lateral temporal lobe. However, SNP rs117863556 interrupts the bindings of TF REST to regulate GAB2 in the DLPFC only. Furthermore, driven by recent discoveries between AD and Covid-19, we found that many genes from our networks regulating Covid-19 pathways are also significantly differentially expressed in severe Covid patients (ICU), suggesting potential regulatory connections between AD and Covid. Thus, we used the machine learning models to predict severe Covid and prioritized highly predictive genes as AD-Covid genes. We also used Decision Curve Analysis to show that our AD-Covid genes outperform known Covid-19 genes for predicting Covid severity and deciding to send patients to ICU or not. In short, our results provide a deeper understanding of the interplay among multi-omics, brain regions, and AD phenotypes, including disease progression and Covid response. Our analysis is open-source available at https://github.com/daifengwanglab/ADSNPheno.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.21.449165v1" target="_blank">Integrative analysis of multi-omics reveals gene regulatory networks across brain regions from risk variants to phenotypes of Alzheimer’s disease and Covid-19</a>
</div></li>
<li><strong>The polarity and specificity of SARS-CoV2 -specific T lymphocyte responses determine disease susceptibility</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Optimal vaccination and immunotherapy against coronavirus disease COVID-19 relies on the in-depth comprehension of immune responses determining the individual susceptibility to be infected by SARS-CoV-2 and to develop severe disease. We characterized the polarity and specificity of circulating SARS-CoV-2-specific T cell responses against whole virus lysates or 186 unique peptides derived from the SARS-CoV-2 or SARS-CoV-1 ORFeome on 296 cancer-bearing and 86 cancer-free individuals who were either from the pre-COVID-19 era (67 individuals) or contemporary COVID-19-free (237 individuals) or who developed COVID-19 (78 individuals) in 2020/21. The ratio between the prototypic T helper 1 (TH1) cytokine, interleukin-2, and the prototypic T helper 2 (TH2) cytokine, interleukin-5 (IL-5), released from SARS-CoV-2-specific memory T cells measured in early 2020, among SARS-CoV-2-negative persons, was associated with the susceptibility of these individuals to develop PCR-detectable SARS-CoV-2 infection in late 2020 or 2021. Of note, T cells from individuals who recovered after SARS-CoV-2 re-infection spontaneously produced elevated levels of IL-5 and secreted the immunosuppressive TH2 cytokine interleukin-10 in response to SARS-CoV-2 lysate, suggesting that TH2 responses to SARS-CoV-2 are inadequate. Moreover, individuals susceptible to SARS-CoV-2 infection exhibited a deficit in the TH1 peptide repertoire affecting the highly mutated receptor binding domain (RBD) amino acids (331-525) of the spike protein. Finally, current vaccines successfully triggered anti-RBD specific TH1 responses in 88% healthy subjects that were negative prior to immunization. These findings indicate that COVID-19 protection relies on TH1 cell immunity against SARS-CoV-2 S1-RBD which in turn likely drives the phylogenetic escape of the virus. The next generation of COVID-19 vaccines should elicit high-avidity TH1 (rather than TH2)-like T cell responses against the RBD domain of current and emerging viral variants.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.18.21258477v1" target="_blank">The polarity and specificity of SARS-CoV2 -specific T lymphocyte responses determine disease susceptibility</a>
</div></li>
<li><strong>Drug offence detection during the pandemic: a spatiotemporal study of drug markets</strong> -
<div>
Research on COVID-19 and crime has so far shown that most crime types declined, especially in the early months of the pandemic. Illicit drug offences were a notable exception, however few studies have considered changes at specific drug market locations. This study documents how key drug markets were affected during the lockdown. Using a spatiotemporal generalised additive model (GAM), this study examines the pattern of drug offence detection throughout the city of Brisbane, Australia and identifies areas of change during lockdown. Statistical meshblock analysis is used to illustrate discrete changes at key market locations. Contrary to aggregate-level analysis, we show that several of the major drug markets experienced a significant decline in drug offence detections, but that these local changes were offset by a displacement to neighbouring areas. We also find some preliminary evidence of the emergence of new outer-urban markets. Existing drug markets were adversely affected by the COVID-19 lockdown, however drug market activity was likely displaced rather than diminished.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/sbh7j/" target="_blank">Drug offence detection during the pandemic: a spatiotemporal study of drug markets</a>
</div></li>
<li><strong>Archiving Dossier Narrative: Transcribing “Le Pelerinage de Damoiselle Sapience”</strong> -
<div>
The archived documents were created for Transcribing “Le Pelerinage de Damoiselle Sapience”: Scholarly Editing Covid19-Style, a digital transcription, edition creation and writing project in November 2020 as part of the 13th Annual (Virtual) Schoenberg Symposium on Manuscript Studies in the Digital Age. International teams of medieval scholars and paleographers divided into three teams the first of which transcribed a unique manuscript copy of Le Pelerinage de Damoiselle Sapience, a previously unedited French-language text that survives in f. 86r-95v of UPenn MS Codex 660. The second team reviewed the work and the third team provided final editorial sign off and created a micro-edition with commentary that was submitted to the journal Digital Medievalist.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/bodoarxiv/m6x2w/" target="_blank">Archiving Dossier Narrative: Transcribing “Le Pelerinage de Damoiselle Sapience”</a>
</div></li>
<li><strong>Depression symptoms mediate mismatch between perceived severity of the COVID-19 pandemic and preventive motives</strong> -
<div>
The present study monitored changes in beliefs about the COVID-19 pandemic, depressive symptoms, and preventive motives between the first wave and the second wave in South Korea using an online survey administered to 1144 individuals nationally representative for age, gender, and areas of residence. While participants correctly updated their beliefs about the worsening pandemic situations, perceived importance of social distancing did not change, and their motives to follow prevention measures shifted toward compulsory rather than voluntary motives. This inconsistency appeared to be mediated by depressive symptoms, such that negative belief changes followed by increased depressive symptoms were associated with decreased perceived importance of social distancing and decreased voluntary motives. Our data highlights the importance of psychological responses to the dynamically evolving pandemic situations in promoting preventive behaviors.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/s4c79/" target="_blank">Depression symptoms mediate mismatch between perceived severity of the COVID-19 pandemic and preventive motives</a>
</div></li>
<li><strong>Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection</strong> -
<div>
A key question in SARS-CoV-2 infection is why viral loads and patient outcomes vary dramatically across individuals. Because spatial-temporal dynamics of viral spread and immune response are challenging to study in vivo, we developed Spatial Immune Model of Coronavirus (SIMCoV), a scalable computational model that simulates hundreds of millions of lung cells, including respiratory epithelial cells and T cells. SIMCoV replicates viral growth dynamics observed in patients and shows that spatially dispersed infections lead to increased viral loads. The model shows how the timing and strength of the T cell response can affect viral persistence, oscillations, and control. By incorporating spatial interactions, SIMCoV provides a parsimonious explanation for the dramatically different viral load trajectories among patients by varying only the number of initial sites of infection, and the magnitude and timing of the T cell immune response. When the branching airway structure is explicitly represented, we find that virus spreads faster than in a 2D layer of epithelial cells, but much more slowly than in an undifferentiated 3D grid or in a well-mixed ODE model. These results illustrate how realistic spatially explicit computational models can improve understanding of within-host dynamics of SARS-CoV-2 infection.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.19.444569v2" target="_blank">Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection</a>
</div></li>
<li><strong>Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary airway epithelium cells</strong> -
<div>
Antiviral therapies are urgently needed to treat and limit the development of severe COVID-19 disease. Ivermectin, a broad-spectrum anti-parasitic agent, has been shown to have anti-SARS-CoV-2 activity in Vero cells at a concentration of 5 micromolar. These in vitro results triggered the investigation of ivermectin as a treatment option to alleviate COVID-19 disease. In April 2021, the World Health Organization stated, however, the following: “the current evidence on the use of ivermectin to treat COVID-19 patients is inconclusive”. It is speculated that the in vivo concentration of ivermectin is too low to exert a strong antiviral effect. Here, we performed a head-to head comparison of the antiviral activity of ivermectin and a structurally related, but metabolically more stable, moxidectin in multiple in vitro models of SARS-CoV-2 infection, including physiologically relevant human respiratory epithelial cells. Both moxidectin and ivermectin exhibited antiviral activity in Vero E6 cells. Subsequent experiments revealed that the compounds predominantly act on a step after virus cell entry. Surprisingly, however, in human airway-derived cell models, moxidectin and ivermectin failed to inhibit SARS-CoV-2 infection, even at a concentration of 10 micromolar. These disappointing results calls for a word of caution in the interpretation of anti-SARS-CoV-2 activity of drugs solely based on Vero cells. Altogether, these findings suggest that, even by using a high-dose regimen of ivermectin or switching to another drug in the same class are unlikely to be useful for treatment against SARS-CoV-2 in humans.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.17.444467v2" target="_blank">Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary airway epithelium cells</a>
</div></li>
<li><strong>Poliovirus Vaccination Induces a Humoral Immune Response that Cross Reacts with SARS-CoV-2</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Millions have been exposed to SARS-CoV-2, but the severity of resultant infections has varied among adults and children, with adults presenting more serious symptomatic cases. Children may possess an immunity that adults lack, possibly from childhood vaccinations. This retrospective study suggests immunization against the poliovirus may provide an immunity to SARS-CoV-2. Methods: Publicly available data were analyzed for possible correlations between national median ages and epidemiological outbreak patterns across 100 countries. Sera from 204 adults and children, who were immunized with the poliovirus vaccine, were analyzed using an enzyme-linked immunosorbent assay. The effects of polio-immune serum on SARS-CoV-2-induced cytopathology in cell culture were then evaluated. Results: Analyses of median population age demonstrated a positive correlation between median age and SARS-CoV-2 prevalence and death rates. Countries with effective poliovirus immunization protocols and younger populations have fewer and less pathogenic cases of COVID-19. Antibodies to poliovirus and SARS-CoV-2 were found in pediatric sera and in sera from adults recently immunized with polio. Western blot demonstrated antibodies recognized the RNA-dependent-RNA-polymerase (RdRp) of either virus. Sera from polio-immunized individuals inhibited SARS-CoV-2 infection of Vero cell cultures. These results suggest the anti-D3-pol-antibody, induced by poliovirus vaccination, may provide a similar degree of protection from SARS-CoV-2 to adults as to children. Conclusions: Poliovirus vaccination induces an adaptive humoral immune response. Antibodies created by poliovirus vaccination bind the RdRp protein of both poliovirus and SARS-CoV-2, thereby preventing SARS-CoV-2 infection. These findings suggest proteins other than spike proteins may be suitable targets for immunity and vaccine development.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.19.21257191v1" target="_blank">Poliovirus Vaccination Induces a Humoral Immune Response that Cross Reacts with SARS-CoV-2</a>
</div></li>
<li><strong>Increased Risk of Severe COVID-19 Disease in Pregnancy in a Multicenter Propensity Score-Matched Study.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Respiratory infections have long been associated with higher maternal and perinatal morbidity. Early data did not report an increased risk of SARS-CoV-2 infection or disease severity in pregnancy. However, surveillance data from the Center for Disease Control and Prevention (CDC) indicates a higher risk of severe disease and death in pregnant women with symptomatic SARS-CoV-2 infection, although this data is subject to ascertainment bias. Objective: To explore the association between COVID-19 disease severity and pregnancy in our university-based hospital system using measures such as COVID-19 ordinal scale severity score, hospitalization, intensive care unit admission, oxygen supplementation, invasive mechanical ventilation, and death. Study design: We conducted a retrospective, multicenter case-control study to understand the association between COVID-19 disease severity and pregnancy. We reviewed consecutive charts of adult females, ages 18-45, with laboratory-confirmed SARS-CoV-2 infection in six months between March 1, 2020, and August 31, 2020. Cases were patients diagnosed with COVID-19 during pregnancy, whereas controls were not pregnant at the time of COVID-19 diagnosis. Primary endpoints were the COVID-19 severity score at presentation (within four hours) and the nadir of the clinical course. The secondary endpoints were the proportion of patients requiring hospitalization, intensive care unit admission, oxygen supplementation, invasive mechanical ventilation, and death. Results: A higher proportion of pregnant women had moderate to severe COVID-19 disease at the nadir of the clinical course than nonpregnant women (25% vs. 16.1%, p=0.04, respectively). While there was a higher rate of hospitalization (25.6% vs. 17.2%), ICU admission (8.9% vs. 4.4%), need for vasoactive substances (5.0% vs. 2.8%), and invasive mechanical ventilation (5.6% vs. 2.8%) in the pregnant group, this difference was not significant after the propensity score matching was applied. We found a high rate of pregnancy complications in our population (40.7%). The most worrisome is the rate of hypertensive disorders of pregnancy (20.1%). Conclusions: In our propensity score-matched study, COVID-19 in pregnancy is associated with an increased risk of disease severity and an increased risk of pregnancy complications.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.18.21258899v1" target="_blank">Increased Risk of Severe COVID-19 Disease in Pregnancy in a Multicenter Propensity Score-Matched Study.</a>
</div></li>
<li><strong>Plasma gradient of soluble urokinase-type plasminogen activator receptor is linked to pathogenic plasma proteome and immune transcriptome and stratifies outcomes in severe COVID-19</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Disease caused by SARS-CoV-2 coronavirus (COVID-19) has resulted in significant morbidity and mortality world-wide. A systemic hyper-inflammation characterizes the severe COVID-19 disease often associated with acute respiratory distress syndrome (ARDS). Blood biomarkers capable of risk stratification are of great importance in effective triage and critical care of severe COVID-19 patients. In the present study we report higher plasma abundance of soluble urokinase-type plasminogen activator receptor (sUPAR), expressed by an abnormally expanded circulating myeloid cell population, in severe COVID-19 patients with ARDS. Plasma sUPAR level was found to be linked to a characteristic proteomic signature of plasma, linked to coagulation disorders and complement activation. Receiver operator characteristics curve analysis identified a cut-off value of sUPAR at 1996.809 pg/ml that could predict survival in our cohort (Odds ratio: 2.9286, 95% confidence interval 1.0427-8.2257). Lower sUPAR level than this threshold concentration was associated with a differential expression of the immune transcriptome as well as favourable clinical outcomes, both in terms of survival benefit (Hazard ratio: 0.3615, 95% confidence interval 0.1433-0.912) and faster disease remission in our patient cohort. Thus we identified sUPAR as a key pathogenic circulating molecule linking systemic hyperinflammation to the hypercoagulable state and stratifying clinical outcomes in severe COVID-19 patients with ARDS.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.19.21259125v1" target="_blank">Plasma gradient of soluble urokinase-type plasminogen activator receptor is linked to pathogenic plasma proteome and immune transcriptome and stratifies outcomes in severe COVID-19</a>
</div></li>
<li><strong>Excellent negative predictive value (99.8%) of two rapid molecular COVID-19 tests compared to conventional RT-PCR for SARS-CoV-2 (COVID-19) in 2,011 tests performed in a single centre.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Conventional Reverse Transcription Polymerase Chain Reaction (RT-PCR) remains the gold standard for testing SARS-CoV-2. Since their availability, two rapid molecular COVID-19 tests were performed in parallel with RT-PCR in all urgent and emergency admissions, as the negative predictive value was not yet ascertained. In this study, we present the data of 2011 test results using either ID Now COVID-19 (Abbott) (Abbott ID NOW) or Xpert Xpress SARS-CoV-2 (Cepheid) (GeneXpert) tests comparing to conventional RT-PCR results. The negative predictive value is 99.8%(3 false negatives out of 1,964 tests) using a cut-off CT value of 40. Using a cut-off of RT-PCR CT value of 30 (predicting infectivity), the negative predictive value is reduced to 99.9% (1 out of 1,964 tests). With these results, we feel confident to recommend the immediate use of the rapid PCR tests alone and to use conventional RT-PCR for confirmation testing after.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.20.21258392v1" target="_blank">Excellent negative predictive value (99.8%) of two rapid molecular COVID-19 tests compared to conventional RT-PCR for SARS-CoV-2 (COVID-19) in 2,011 tests performed in a single centre.</a>
</div></li>
<li><strong>Role of physiotherapy team in critically ill COVID-19 patients pronation: can a multidisciplinary management reduce the complications rate?</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives: During the pandemic, critically ill COVID-19 patients9 management presented an increased workload for Intensive Care Unit (ICU) nursing staff, particularly during pronation maneuvers, with high risk of complications. In this scenario, a support during pronation by the ICU Physiotherapy Team was introduced. Research methodology: Retrospective analysis. Consecutive critically ill COVID-19 patients. Setting: A COVID-19 Center in southern Switzerland, between March 16th and April 30th, 2020. Main Outcome Measures: Rates and characteristics of pronation-related complications. Results: Forty-two patients on mechanical ventilation (MV) were treated; 296 standard prone/supine positioning were performed, with 3.52 cycles/patient. One (0.3%) major complication was observed, while fourteen (33.3%) patients developed minor complications, e.g. pressure injuries. The incidence of pressure sores was related to ICU length-of-stay (LOS) (p = 0.029) and MV days (p = 0.015), while their number (n = 27) further correlated with ICU LOS (p = 0.001) and MV days (p = 0.001). The propensity matching score analysis did not show any protective factor of pronation regarding pressure injuries (p = 0.448). No other significant correlation was found. Conclusion: The specific pronation team determined a low rate of major complications in critically ill COVID19 patients. The high rate of minor complications appeared to be related to disease severity, rather than from pronation.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.20.21258949v1" target="_blank">Role of physiotherapy team in critically ill COVID-19 patients pronation: can a multidisciplinary management reduce the complications rate?</a>
</div></li>
<li><strong>Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The SARS-CoV-2 variant of concern B.1.617.2 displaced B.1.1.7 as the dominant variant in England and other countries. This study aimed to determine whether B.1.617.2 was also displacing B.1.1.7 in the United States. We analyzed PCR testing results and viral sequencing results of samples collected across the United States, and showed that B.1.1.7 was rapidly being displaced and is no longer responsible for the majority of new cases. The percentage of SARS-CoV-2 positive cases that are B.1.1.7 dropped from 70% in April 2021 to 42% in just 6 weeks. Our analysis showed rapid growth of variants B.1.617.2 and P.1 as the primary drivers for this displacement. Currently, the growth rate of B.1.617.2 was higher than P.1 in the US (0.61 vs. 0.22), which is consistent with reports from other countries. Lastly, we showed that B.1.617.2 was growing faster in counties with a lower vaccination rate.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.20.21259195v1" target="_blank">Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States</a>
</div></li>
<li><strong>Determining a novel feature-space for SARS-CoV-2 sequence data</strong> -
<div>
The pandemicity &amp; the ability of the SARS-COV-2 to reinfect a cured subject, among other damaging characteristics of it, took everybody by surprise. A global collaborative scientific effort was direly required to bring learned people from different niches of medicine &amp; data science together. Such a platform was provided by COVID19 Virtual BioHackathon, organized from the 5th to the 11th of April, 2020, to ponder on the related pressing issues varying in their diversity from text mining to genomics. Under the “Machine learning” track, we determined optimal k-mer length for feature extraction, constructed continuous distributed representations for protein sequences to create phylogenetic trees in an alignment-free manner, and clustered predicted MHC class I and II binding affinity to aid in vaccine design. All the related work in available in a Github repository under an MIT license for future research.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://biohackrxiv.org/xt7gw/" target="_blank">Determining a novel feature-space for SARS-CoV-2 sequence data</a>
</div></li>
<li><strong>Book Review of “Implementation of Online Learning in The Era of Covid-19”</strong> -
<div>
Online learning is implemented during Covid-19 era to reduce the risk of transmission to the community. Online learning is carried out not only in Indonesia, but also in various other countries. Online Learning does not only provide advantages and benefits but also there are some risk, impacts and obstacles faced during online learning. The implementation of online learning also has factors that support success in implementing it.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/k58hg/" target="_blank">Book Review of “Implementation of Online Learning in The Era of Covid-19”</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ivermectin Treatment Efficacy in Covid-19 High Risk Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ivermectin 0.4mg/kg/day for 5 days<br/><b>Sponsor</b>:   Clinical Research Centre, Malaysia<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MP1032 Treatment in Patients With Moderate to Severe COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: MP1032;   Drug: Placebo<br/><b>Sponsors</b>:   MetrioPharm AG;   Syneos Health, LLC<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of XAV-19 for the Treatment of Moderate-to-severe COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: XAV-19;   Drug: Placebo<br/><b>Sponsor</b>:   Xenothera SAS<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Codivir in Patients With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Covidir injections;   Diagnostic Test: One Step Test;   Diagnostic Test: IgM and IgG dosage;   Diagnostic Test: RT-PCR SARS-CoV-2;   Diagnostic Test: Screening blood test;   Diagnostic Test: ECG;   Diagnostic Test: Medical evaluation;   Diagnostic Test: NEWS-2 score;   Diagnostic Test: WHO score<br/><b>Sponsors</b>:   Code Pharma;   Zion Medical<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In Situ Thrombolysis With tPA and Inflow Perfusion Analysis in Patient With Severe Covid-19 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: tPA<br/><b>Sponsor</b>:   Grupo Mexicano para el Estudio de la Medicina Intensiva<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Safety and Concentrations of Monoclonal Antibody Against Virus That Causes COVID-19 Disease.</strong> - <b>Condition</b>:   COVID-19 Virus Disease<br/><b>Interventions</b>:   Biological: MAD0004J08;   Other: Placebo<br/><b>Sponsors</b>:   Toscana Life Sciences Sviluppo s.r.l.;   Cross Research S.A.<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Vitamin C;   Drug: N-acetylcysteine (NAC);   Drug: NAC + Bromhexine (BMX)<br/><b>Sponsors</b>:   Universidade Federal do Ceara;   Paulista School of Medicine-EPM, UNIFESP;   Health Surveillance Secretariat - SVS;   Central Laboratory of Public Health of Ceara - LACEN-CE;   Leonardo da Vinci Hospital - HLV;   São José Hospital for Infectious Diseases - HSJ;   Ceará Health Secretariat - SESA;   Municipal Health Secretary - SMS-Fortaleza<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Osteopathic Manipulative Treatment (OMT)<br/><b>Sponsors</b>:   Western University of Health Sciences;   American College of Osteopathic Physicians;   American Osteopathic Foundation;   Osteopathic Physicians and Surgeons of California;   Xavier-Nichols Foundation<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nervous System Symptoms Associated With COVID 19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: NEURO +;   Other: NEURO -<br/><b>Sponsor</b>:   University Hospital, Toulouse<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tolerability,Safety of JS016 in SARS-CoV-2 (COVID-19)</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2<br/><b>Intervention</b>:   Drug: Combination Product: JS016 (anti-SARS-CoV-2 monoclonal antibody)<br/><b>Sponsor</b>:   Peking Union Medical College Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Open Label, Single-Center Study Utilizing BIOZEK COVID-19 Antigen Rapid Test</strong> - <b>Condition</b>:   Covid-19 Testing<br/><b>Intervention</b>:   Diagnostic Test: Biozek Covid-19 Antigen Rapid Test (Saliva)<br/><b>Sponsor</b>:   Mach-E B.V.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Community-based Post-exposure Prophylaxis for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Guduchi Ghanvati;   Other: Standard guidelines<br/><b>Sponsors</b>:   NMP Medical Research Institute;   Aarogyam UK;   Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University;   Samta Ayurveda Prakoshtha, India;   Padmanabhama Ayurveda Hospital and Research Centre<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vitamin A Supplementation in Children With Moderate to Severe COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Dietary Supplement: Vitamin A supplement<br/><b>Sponsor</b>:   Shiraz University of Medical Sciences<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cerebral Autoregulation and COVID-19</strong> - <b>Conditions</b>:   COVID-19 Acute Respiratory Distress Syndrome;   COVID-19 Pneumonia<br/><b>Intervention</b>:   Other: NIRS (Near-Infrared Spectroscopy)<br/><b>Sponsor</b>:   University of Athens<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Favipiravir +/- Nitazoxanide: Early Antivirals Combination Therapy in COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Favipiravir;   Drug: Nitazoxanide;   Other: Nitazoxanide Placebo<br/><b>Sponsors</b>:   Coordinación de Investigación en Salud, Mexico;   University College, London;   Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional (CINVESTAV);   Universidad Autonoma de Guadalajara;   Siegfried Rhein S.A. de C.V.;   Strides Pharma Science Limited;   Hakken Enterprise<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals</strong> - Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Accordingly, compound-driven induction of autophagy limits SARS-CoV-2 propagation. In detail, SARS-CoV-2-infected cells show accumulation of key metabolites, activation of autophagy…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Design of optical cavity for air sanification through ultraviolet germicidal irradiation</strong> - The transmission of airborne pathogens represents a major threat to worldwide public health. Ultraviolet light irradiation can contribute to the sanification of air to reduce the pathogen transmission. We have designed a compact filter for airborne pathogen inactivation by means of UVC LED sources, whose effective irradiance is enhanced thanks to high reflective surfaces. We used ray-tracing and computational fluid dynamic simulations to model the device and to maximize the performance inside…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronaviruses, cholesterol and statins: Involvement and application for Covid-19</strong> - The infectious power of coronaviruses is dependent on cholesterol present in the membranes of their target cells. Indeed, the virus enters the infected cell either by fusion or by endocytosis, in both cases involving cholesterol-enriched membrane microdomains. These membrane domains can be disorganized in-vitro by various cholesterol-altering agents, including statins that inhibit cell cholesterol biosynthesis. As a consequence, numerous cell physiology processes, such as signaling cascades, can…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential for the Repurposing of Adamantane Antivirals for COVID-19</strong> - Several adamantanes have established actions against coronaviruses. Amantadine, rimantadine, bananins and the structurally related memantine are effective against human respiratory coronavirus HCoV-OC43, bovine coronavirus and severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and a spiroadamantane amine is effective against the coronavirus strain 229E. Molecular docking studies suggest that amantadine may block the viral E protein channel, leading to impaired viral propagation….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virtual screenings of the bioactive constituents of tea, prickly chaff, catechu, lemon, black pepper, and synthetic compounds with the main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE 2) of SARS-CoV-2</strong> - CONCLUSION: Therefore, the selected compounds could be considered a potential herbal treatment source against SARS-CoV-2.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies</strong> - Bruton’s tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR). Targeting of BTK with small molecule inhibitors has proven to be efficacious in several B cell malignancies. Interestingly, recent studies reveal increased BTK protein expression in circulating resting B cells of patients with systemic autoimmune disease (AID) compared with healthy controls. Moreover, BTK…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring the Psychological Effects of COVID-19 Home Confinement in China: A Psycho-Linguistic Analysis on Weibo Data Pool</strong> - CONCLUSION: Home confinement caused a decline in the use of positive emotion words. This indicates that home confinement can increase the frequency of negative emotions. The changes of exclusion words and inhibition words in high-endemic areas may be related to the high epidemic threat and the urgent need for social distancing in these areas.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of New Potent anti-MERS CoV Fusion Inhibitors</strong> - Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through competition with heptad repeat domain 2 (HR2) at its HR1 binding site. We designed eleven peptides with stronger estimated HR1 binding affinities than the wild-type peptide to prevent viral fusion with the cell membrane. Eight peptides showed strong…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“Surfactants - compounds for inactivation of SARS-CoV-2 and other enveloped viruses”</strong> - We provide here a general view on the interactions of surfactants with viruses, with a particular emphasis on how such interactions can be controlled and employed, for inhibiting the infectivity of enveloped viruses, including coronaviruses. The aim is to provide to interested scientists from different fields, including chemistry, physics, biochemistry, and medicine, an overview over the basic properties of surfactants and (corona)viruses, which are relevant to understanding the interactions…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19: In silico identification of potent alpha-ketoamide inhibitors targeting the main protease of the SARS-CoV-2</strong> - The COVID-19 has been creating a global crisis, causing countless deaths and unbearable panic. Despite the progress made in the development of the vaccine, there is an urge need for the discovery of antivirals that may better work at different stages of SARS-CoV-2 reproduction. The main protease (M^(pro)) of the SARS-CoV-2 is a crucial therapeutic target due to its critical function in virus replication. The α-ketoamide derivatives represent an important class of inhibitors against the M^(pro)…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fragment-based in silico design of SARS CoV-2 main protease inhibitors</strong> - 3CLpro is essential for SARS-CoV-2 replication and infection; its inhibition using small molecules is a potential therapeutic strategy. In this study, a comprehensive crystallography-guided fragment-based drug discovery approach was employed to design new inhibitors for SARS-CoV-2 3CLpro. All small molecules co-crystallized with SARS-CoV-2 3CLpro with structures deposited in the Protein Data Bank were used as inputs. Fragments sitting in the binding pocket (87) were grouped into eight…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors</strong> - The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global pandemic coronavirus disease (COVID-19), but no specific antiviral drug has been proven effective for controlling this pandemic to date. In this study, several 2-((indol-3-yl)thio)-N-benzyl-acetamides were identified as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors. After a two-round optimization, a new series of 2-((indol-3-yl)thio)-N-benzyl-acetamides was designed, synthesized,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial</strong> - BACKGROUND: The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental and early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary capillary leak.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019, it binds to angiotensin-converting enzyme 2 (ACE2) to enter into human cells. The expression level of ACE2 potentially determine the susceptibility and severity of COVID-19, it is thus of importance to understand the regulatory mechanism of ACE2 expression. Tripartite motif containing 28 (TRIM28) is known to be involved in multiple processes including antiviral restriction, endogenous…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>From Cancer to COVID-19: A Perspective on Targeting Heparan Sulfate-Protein Interactions</strong> - Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate a vast array of biological and pathological processes. Inhibition of HS-protein interactions is thus an attractive approach for new therapeutic development for cancer and infectious diseases, including COVID-19; however, synthesis of well-defined native HS oligosaccharides remains challenging. This has aroused…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 anti-viral therapeutic</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU327160071">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>폐마스크 밀봉 회수기</strong> - 본 발명은 마스크 착용 후 버려지는 일회용 폐마스크를 비닐봉지에 넣은 후 밀봉하여 배출함으로써, 2차 감염을 예방하고 일반 생활폐기물과 선별 분리 배출하여 환경오염을 방지하는 데 그 목적이 있다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR325788342">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COST EFFECTIVE PORTABLE OXYGEN CONCENTRATOR FOR COVID-19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU324964715">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA)</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323956811">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Erweiterbare Desinfektionsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Erweiterbare Desinfektionsvorrichtung, umfassend: einen Hauptkörper, der eine umgekehrt U-förmige Basisplatte aufweist, wobei die umgekehrt U-förmige Basisplatte mit einer Öffnung versehen ist und jeweils eine Seitenplatte sich von zwei Seiten der umgekehrt U-förmigen Basisplatte nach außen erstreckt; und mindestens eine Desinfektionslampe, die in den auf zwei Seiten des Hauptkörpers befindlichen Seitenplatten angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402480">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Einfache Sterilisationsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Einfache Sterilisationsvorrichtung, mit einem Hauptkörper (11), der in Längsrichtung einen ersten Plattenabschnitt (111) und in Querrichtung einen zweiten Plattenabschnitt (112) aufweist, wobei der erste Plattenabschnitt (111) und der zweite Plattenabschnitt (112) L-förmig miteinander verbunden sind; und einer Sterilisationslampe (12), die an dem Hauptkörper (11) angeordnet ist und eine Lichtemissionseinheit (121), eine Sensoreinheit (122), eine Steuereinheit (123) und eine Stromeinheit (124) aufweist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402479">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Klemmarme aufweisende Desinfektionsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Klemmarme aufweisende Desinfektionsvorrichtung, umfassend: einen Hauptkörper; eine Desinfektionslampe, die im Hauptkörper angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst; einen Klemmabschnitt, der auf einer Seite des Hauptkörpers angeordnet ist, wobei der Klemmabschnitt zwei gegenüberliegende Greifbacken umfasst, wobei mindestens eine der beiden Greifbacken mit einer Schwenkachse versehen ist, wobei ein Klemmraum durch passgenaues Schließen der beiden Greifbacken entsteht und die beiden Greifbacken jeweils mit einem Durchgangsloch versehen sind; einen Befestigungsabschnitt, der durch die Durchgangslöcher der beiden Greifbacken hindurchgeführt ist;und ein Schild, das auf einer Seite des Klemmabschnitts angeordnet und mit einem Aufnahmeloch versehen ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402478">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aufhängbare Sterilisationsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Aufhängbare Sterilisationsvorrichtung, mit einem Hauptkörper (11); einer Sterilisationslampe (12), die an dem Hauptkörper (11) angeordnet ist und eine Lichtemissionseinheit (121), eine Sensoreinheit (122), eine Steuereinheit (123) und eine Stromeinheit (124) aufweist; einem Klemmabschnitt (13), der an einer Seite des Hautpkörpers (11) angeordnet ist und zwei gegenüberliegend angeordnete Klemmbacken (131) aufweist, wobei mindestens eine der beiden Klemmbacken (131) mit einem Achsbolzen (132) versehen ist, wobei die beiden Klemmbacken (131) beim Schließen einen Klemmraum (134) bilden, und wobei die beiden Klemmbacken (131) jeweils mit einem Durchgangsloch (135) versehen sind; und einem Befestigungselement (14), das durch die Durchgangslöcher (135) der beiden Klemmbacken (131) hindurchgeführt wird.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402477">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sterilisationsvorrichtung zur Verbesserung der Desinfektionswirkung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Sterilisationsvorrichtung zur Verbesserung der Desinfektionswirkung, umfassend: einen Hauptkörper, der eine erste Oberfläche, eine von der ersten Oberfläche abgewandte zweite Oberfläche und ein Aufnahmeloch aufweist, wobei die zwei Seiten des Hauptkörpers jeweils mit einem Durchgangsloch versehen sind, wobei die Durchgangslöcher mit dem Aufnahmeloch durchgängig verbunden sind; eine Desinfektionslampe, die auf der zweiten Oberfläche des Hauptkörpers angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst; und ein Befestigungsteil, das durch die Durchgangslöcher und das Aufnahmeloch des Hauptkörpers hindurchgeführt ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402481">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295937">link</a></p></li>
</ul>
<script>AOS.init();</script></body></html>

348
archive-daily-dose/22 June, 2021.html Normal file
View File

@ -0,0 +1,348 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>22 June, 2021</title>
<style type="text/css">
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
</style>
<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How a Conservative Activist Invented the Conflict Over Critical Race Theory</strong> - To Christopher Rufo, a term for a school of legal scholarship looked like the perfect weapon. - <a href="https://www.newyorker.com/news/annals-of-inquiry/how-a-conservative-activist-invented-the-conflict-over-critical-race-theory">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Joe Biden Just Had a Summit with Vladimir Putin and Nothing Crazy Happened</strong> - The triumph of Geneva is that it was not Helsinki. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/joe-biden-just-had-a-summit-with-vladimir-putin-and-nothing-crazy-happened">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What Is Going On at Yale Law School?</strong> - The prestigious institution has tied itself in knots over a dispute involving one of its most popular—and controversial—professors, Amy Chua. - <a href="https://www.newyorker.com/news/annals-of-education/what-is-going-on-at-yale-law-school">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Will Joe Biden and Lina Khan Cut the Tech Giants Down to Size?</strong> - A leading figure in the movement to rein in Silicon Valley monopolies has a powerful new post. - <a href="https://www.newyorker.com/news/our-columnists/will-joe-biden-and-lina-khan-cut-the-tech-giants-down-to-size">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Do So Many New York Politicians Want Paperboy Prince to Hit Them in the Face with a Pie?</strong> - “Y’all haven’t seen what I do with confetti,” the candidate bent on upstaging the mayor’s race said. - <a href="https://www.newyorker.com/news/our-local-correspondents/why-do-so-many-new-york-politicians-want-paperboy-prince-to-hit-them-in-the-face-with-a-pie">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Your power company can turn up your smart thermostat remotely — if you let it</strong> -
<figure>
<img alt="A person operating a Google Nest smart thermostat." src="https://cdn.vox-cdn.com/thumbor/ISeEpa2KKdueeJE6cmLZddbTcRQ=/295x0:2247x1464/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69483860/GettyImages_1230423891.0.jpg"/>
<figcaption>
Is your Google Nest smart thermostat being controlled by you or by your power company? | Gina Ferazzi/Los Angeles Times via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
You may not be the only one controlling your smart thermostat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VlJqO6">
Texas’s power grid is unpleasantly surprising its users again. After last winter’s storm disabled parts of the grid for <a href="https://www.vox.com/2021/2/16/22284140/texas-blackout-outage-winter-storm-uri-ercot-power-grid-cold-snow-austin-houston-dallas">several days</a>, causing potentially <a href="https://www.buzzfeednews.com/article/peteraldhous/texas-winter-storm-power-outage-death-toll">hundreds of deaths</a>, a summer heat wave is once again <a href="https://www.nytimes.com/2021/06/15/climate/texas-heat-wave-electricity.html">threatening the grid</a>. One potential solution Texas power companies have found is to turn up the temperature on some customers’ smart thermostats. Problem is, some of those customers weren’t aware that their power company could and would do such a thing — until their homes got uncomfortably warm.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pojLos">
One Houston family <a href="https://www.khou.com/article/news/local/texas/remote-thermostat-adjustment-texas-energy-shortage/285-5acf2bc5-54b7-4160-bffe-1f9a5ef4362a">told a local news affiliate</a> that their smart thermostat was turned up to 78 degrees with seemingly no notice other than a text sent after the fact. When they enrolled in a program called “Smart Savers Texas” — entering them in a sweepstakes to win up to $5,000 off their energy bills for the next year — these users didn’t realize that this also gave the power company permission to adjust their thermostat during high demand periods, like heat waves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Bl4k8s">
The idea of a power company turning up your thermostat like a <a href="https://melmagazine.com/en-us/story/dads-and-air-conditioning">stereotypical electricity-bill-conscious dad</a> might seem dystopian, but it’s also fairly common. There are programs like Smart Savers Texas all over the country, from <a href="https://www.pge.com/en_US/residential/save-energy-money/savings-solutions-and-rebates/smart-ac/smart-ac.page?WT.mc_id=Vanity_smartac">California</a> to <a href="https://www.nationalgridus.com/MA-Home/Connected-Solutions/Thermostat-Program">New England</a>. The idea behind them is to decrease power consumption to alleviate stress on the electrical grid and avoid brownouts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DeDIwt">
Since customers aren’t likely to volunteer to use less of the power they pay for when they need it most, these programs give them an incentive and the means to do so easily (by proxy). Some programs provide better incentives than others. When it launched in 2011, Philadelphia’s Smart A/C Saver program gave participants a <a href="https://www.inquirer.com/philly/business/20110615_Peco_offers__120_to_customers_for_energy-saving_program.html">$120 bill credit</a> (apparently this was too generous, as it was reduced to $40 in subsequent years). But Smart Savers Texas only offers customers the chance to win free power for a year, and apparently it didn’t make its terms very clear.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="01PL7b">
But sometimes, the program’s terms were a little too good for customers. New York City’s <a href="https://www.ny1.com/nyc/all-boroughs/money-matters/2016/06/13/keep-your-apartment-cool-on-the-go-with-con-ed-s-smart-ac-program">Smart AC Program</a>, which gave participants smart plugs and gift cards, ended in 2020 because, Con Edison said, it <a href="http://documents.dps.ny.gov/public/Common/ViewDoc.aspx?DocRefId=%7BA4FB6989-450B-4784-9DFD-9DE1CA57C677%7D">wasn’t cost-effective</a>. Philadelphia’s PECO <a href="https://www.inquirer.com/business/peco-discontinues-smart-a-c-saver-energy-conservation-program-20201118.html">ended its similar program</a>, with the $40 bill discount, last fall.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ux4xL3">
Power companies usually do these programs in partnerships with the tech companies that provide the devices. Smart Savers Texas is administered by a company called EnergyHub and is available through smart thermostats made by Alarm.com, Lux, Google’s Nest, Radio Thermostat, Sensi, Vivint, and ecobee.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JyfpEd">
Google’s Nest even has its own “<a href="https://store.google.com/us/collection/rebates_and_rewards?hl=en-US&amp;GoogleNest">Rush Hour Rewards</a>” program available through participating power companies. The rewards vary. In one New York zip code, for instance, ConEd offers “up to” $85 if you enroll in the program, while National Grid is only giving out a $25 gift card. Some power companies also offer discounts on the smart thermostats themselves. And Google seems to hope there’s room to expand its Rush Hour Rewards beyond just temperature, too: Nest’s head of energy partnerships <a href="https://blog.google/inside-google/googlers/ask-techspert-how-can-we-fight-energy-rush-hours/">said in April</a> that “in the future, your electric vehicle or even your whole home may be able to join in.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NaETSy">
These programs are currently opt in, unlike the aforementioned stereotypical electricity-bill-conscious dad. But if the Texas example is anything to go by, there are some people who didn’t realize what they were getting into. If you’re afraid you might be one of them and you don’t want to be, now would be a good time to check with your power company to make sure you aren’t, especially if you have a smart thermostat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LiapoG">
It’s also a good reminder to always check the fine print, especially if you’re being offered something for what appears to be nothing in return. There’s always a catch.
</p></li>
<li><strong>The Supreme Court’s unanimous decision on paying NCAA student-athletes, explained</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/Yjf9lQLf5VZVpcI-nr4VuP7sdyw=/0x0:2215x1661/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69482141/516782514.0.jpg"/>
<figcaption>
Maryland Terrapins forward Jake Layman in a 2016 NCAA tournament. | Toni L. Sandys/Washington Post/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It’s a narrow win for the athletes, but it could foreshadow a much bigger victory.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nrAZwv">
The Supreme Court handed down a heavily caveated victory for elite college athletes on Monday. The immediate impact of the Court’s unanimous decision in <a href="https://www.supremecourt.gov/opinions/20pdf/20-512_gfbh.pdf"><em>National Collegiate Athletic Association v. Alston</em></a> is that many elite student-athletes will receive additional education-related compensations, such as additional scholarship money. But the case could have broader implications and could eventually lead to these athletes being paid salaries.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NrHdr4">
The Court’s decision is the final chapter in a <a href="https://www.vox.com/22348385/supreme-court-ncaa-alston-football-basketball-march-madness-college-sports-antitrust">lengthy legal fight that began in 2014</a>. Several athletes from the highest levels of college sports — men’s and women’s Division I basketball, plus football players in the NCAA’s elite “Football Bowl Subdivision” — filed this suit seven years ago. They challenged rules enforced by the NCAA and various other governing bodies within college sports, which place fairly strict limits on athlete compensation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UVelEK">
To be clear, these athletes weren’t uncompensated. Many elite athletes received scholarships that covered their tuition, room, and board. Some players could also receive <a href="https://casetext.com/case/alston-v-natl-collegiate-athletic-assn-in-re-natl-collegiate-athletic-assn-athletic-grant-in-aid-cap-antitrust-litig-1">small cash stipends</a> to cover living expenses, plus perks such as meals and medical care for sports-related injuries. But they did not receive anywhere near the sort of stratospheric salaries that are available to the best professional athletes — or any salary at all.
</p>
<div class="c-float-right">
<div id="Sf9e4s">
<div>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MERme2">
Elite student-athletes receive fairly meager compensation, moreover, despite the fact that they are enormous profit centers for their universities — and an array of merchants and broadcasters that profit off of college sports. In the 2015-16 academic year, for example, Division I basketball and Division I-A football <a href="https://casetext.com/case/alston-v-natl-collegiate-athletic-assn-in-re-natl-collegiate-athletic-assn-athletic-grant-in-aid-cap-antitrust-litig-1">generated $4.3 billion in revenue</a>. The NCAA’s current broadcast agreement for its annual March Madness basketball tournament is <a href="https://www.supremecourt.gov/opinions/20pdf/20-512_gfbh.pdf">worth over a billion dollars annually</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WCaXCN">
Over the course of the <em>Alston</em> litigation, two lower courts held that some — but not all — of the NCAA’s restrictions on athlete compensation must be struck down. As Justice Neil Gorsuch summarizes these lower court decisions in his opinion for the Supreme Court, the lower courts lifted “rules that limit scholarships for graduate or vocational school, payments for academic tutoring, or paid posteligibility internships,” while leaving in place “rules aimed at ensuring ‘student athletes do not receive unlimited payments unrelated to education.’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LDbqko">
Gorsuch’s opinion leaves in place these lower court decisions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YNnzt8">
In essence, that means that athletes may receive additional education-related payments, such as scholarships for graduate school, but the Supreme Court’s decision still allows the NCAA to prevent student-athletes from being paid like professional athletes. That said, one member of the Court argues in a separate opinion that student-athletes should receive much broader relief if they file a new lawsuit challenging all of the NCAA’s limits on compensation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yEAaQW">
The NCAA hoped to avoid this outcome by arguing that it should effectively be exempted from antitrust rules that prevent businesses from colluding with their competitors to set workers’ compensation. The upshot of Gorsuch’s opinion is that, at least in a case like this one, the NCAA has to follow the same antitrust rules as everyone else — though that may not be true in every future case alleging that a sports league violates federal antitrust law.
</p>
<h3 id="8WigQA">
The NCAA claimed it was beyond the reach of antitrust law because it is a “joint venture”
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J4jbnh">
The NCAA’s rules limiting player compensation are, in the parlance of antitrust law, a “<a href="https://www.vox.com/22348385/supreme-court-ncaa-alston-football-basketball-march-madness-college-sports-antitrust">horizontal agreement</a>.” That is, they are an agreement to set prices among multiple businesses that compete at the same level within the college sports industry.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Zmrnj">
As the Supreme Court explained in <a href="https://caselaw.findlaw.com/us-supreme-court/468/85.html"><em>NCAA v. Board of Regents of the University of Oklahoma</em></a> (1984), “horizontal price fixing and output limitation are ordinarily condemned as a matter of law under an ‘illegal per se’ approach because the probability that these practices are anticompetitive is so high.” When competitors collude with each other to depress wages, the courts typically come down upon those employers with a hammer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bNV1Nn">
But the <em>Board of Regents</em> decision also suggests that federal antitrust law does not always apply with its full force toward sports leagues.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="riziSv">
Such leagues are known as “joint ventures” by antitrust lawyers. The very nature of team sports is that multiple teams must agree to compete together under a common set of rules. They must agree on when to schedule games and where those games will take place. For these reasons, the courts typically allow sports teams to engage in some degree of collusion with each other — and to form umbrella organizations such as the NCAA, which set rules for many teams — because competitive sports cannot exist without some amount of mutual agreement.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y3yhwf">
The upshot of the Court’s decision in <em>Alston</em>, however, is that the special solicitude that antitrust law typically gives to sports leagues does not extend to the NCAA’s attempts to limit player compensation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xFrwPK">
The fact that some degree of collusion among competitors is “necessary to create or maintain a league sport,” Gorsuch writes, “does not mean all ‘aspects of elaborate interleague cooperation are.’” Though league sports cannot exist without common rules and a common schedule, “nobody questions that Division I basketball and FBS football can proceed (and have proceeded) without the education-related compensation restrictions the district court enjoined; the games go on.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UJocYX">
Thus, the NCAA cannot dodge compliance with federal antitrust law.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1xAVVz">
Additionally, the NCAA argued that paying their athletes more would fundamentally alter the product that the NCAA provides to consumers. That product, according to the NCAA, is “amateur” athletics offered by poorly compensated student-athletes, not by professionals paid a market salary. But the Court treated this argument fairly dismissively.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RkAFNe">
Among other things, Gorsuch noted in his opinion, “the NCAA’s conception of amateurism has changed steadily over the years.” A former commissioner of college sports’ Southeastern Conference even testified that he’s “never been clear on … what is really meant by amateurism.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6Dr10m">
So it’s hard for the NCAA to claim that it offers some unique product, grounded in “amateurism,” when it can’t even stick to a single definition of what it means to be an “amateur” athlete.
</p>
<h3 id="YeQrnt">
The NCAA may suffer an even more significant loss in a future case
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4jE7vq">
The lower courts struck down the NCAA’s limits on education-related compensation for athletes, but left in place other limits on compensation — and the Supreme Court upheld this baby-splitting result in <em>Alston</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Pl2EfI">
But, as Gorsuch notes in his opinion, a major reason why the Supreme Court did not go further is that the plaintiffs did not ask them to do so. As he writes, “the student athletes [did] not renew their across-the-board challenge to the NCAA’s compensation restrictions” when their case reached the Supreme Court.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DdkAlp">
Although the full Court did not weigh in on whether elite student-athletes should be entitled to more compensation than the <em>Alston</em> opinion requires, Justice Brett Kavanaugh wrote a separate concurring opinion where he argues that “the NCAA’s remaining compensation rules also raise serious questions under the antitrust laws.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lX4FCd">
As Kavanaugh writes, “the NCAA’s business model would be flatly illegal in almost any other industry in America.” Among other things, the NCAA “controls the market for college athletes;” it “concedes that its compensation rules set the price of student athlete labor at a below-market rate”; and it “recognizes that student athletes currently have no meaningful ability to negotiate with the NCAA over the compensation rules.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NJAtBd">
That’s exactly the sort of iron grip over pricing that antitrust laws are supposed to prevent.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3oEp95">
It remains to be seen whether Kavanaugh’s opinion will someday become the law, but it will likely signal to student-athletes that they should consider filing a new lawsuit challenging the NCAA’s remaining restrictions on compensation.
</p></li>
<li><strong>Democrats’ voting rights bill is a big test for Biden’s global democracy agenda</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/ni0uyCuV0BEz3LZ69IIcIZpg4M0=/218x0:4177x2969/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69482051/1077147188.0.jpg"/>
<figcaption>
House Speaker Nancy Pelosi speaks alongside Democratic members of the House about HR 1, known as the For the People Act, in Washington, DC, on January 4, 2019. | Saul Loeb/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Why HR 1, known as the For the People Act, is intricately linked with Biden’s foreign policy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9i5Dh5">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PUCeCc">
Getting Democrats’ <a href="https://www.vox.com/2021/3/3/22309123/house-democrats-pass-voting-rights-bill-hr1">voting rights bill</a> passed isn’t just important to the Biden administration’s democracy agenda at home. It would also underscore a major pillar of the president’s foreign policy: strengthening the appeal of democracy worldwide by proving democratic governments can deliver for their people.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SdyhLE">
The <a href="https://www.vox.com/2021/3/3/22309123/house-democrats-pass-voting-rights-bill-hr1">800-page HR 1 legislation</a>, known as the For the People Act, <a href="https://www.usatoday.com/story/news/politics/2021/06/21/voting-rights-bill-senate-poised-vote-republicans-opposed/7708277002/">passed in the House on a near party-line vote in March</a>. Among many other measures, the bill aims to make it easier for Americans to vote in elections, bring more transparency to how candidates are financed, and bolster government ethics provisions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xzuM63">
Democrats say these changes are necessary to counter <a href="https://www.npr.org/2021/06/01/1002101600/here-are-the-texas-gops-reasons-for-voter-restrictions-and-critics-replies">restrictive voting laws</a> being pushed by Republicans in many states; Republicans see the bill as a <a href="https://www.heritage.org/election-integrity/report/the-facts-about-hr-1-the-the-people-act-2019">sweeping set of reforms</a> designed to <a href="https://abcnews.go.com/Politics/gop-warns-hr-absolutely-devastating-republicans/story?id=76555647">help Democrats win in future elections</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="flyVjs">
It’s unclear if HR 1 will pass in its current form, or at all. Senate Majority Leader Chuck Schumer will bring it up for a procedural vote on Tuesday, where lawmakers will decide if the bill should come up for an approve-or-deny vote in the future. Most analysts say the <a href="https://www.politico.com/newsletters/playbook/2021/06/21/this-week-in-washington-biden-takes-on-rising-crime-493306">bill won’t clear that hurdle</a>, potentially killing HR 1 for good in this Congress.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="upwCEx">
That would be a serious blow to Biden’s domestic agenda. After the House passed the bill in March, the <a href="https://www.whitehouse.gov/briefing-room/statements-releases/2021/03/04/statement-by-president-joe-biden-on-the-house-of-representatives-passage-of-h-r-1/">president said</a> its measures were “urgently needed to protect that right [to vote], to safeguard the integrity of our elections, and to repair and strengthen our democracy.” Biden even made <a href="https://www.nytimes.com/2021/06/03/us/politics/kamala-harris-voting-rights-laws.html">Vice President Kamala Harris</a> his point person for voting rights.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eIAnoQ">
But on a grander scale, it could potentially harm the core message of Biden’s foreign policy. “Biden’s global democracy agenda depends on US democracy continuing to strengthen at home,” said Heather Hurlburt, a director at the New America think tank in Washington, DC, and so far the record is “terrible on voting rights and election integrity. So turning those around is important.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uSkjh6">
Simply put, Biden’s democratic vision for the world is intricately linked with HR 1’s future in Congress — and at the moment, that vision is in serious jeopardy.
</p>
<h3 id="nZ2KFw">
If HR 1 doesn’t pass, Biden could struggle to promote democracy abroad
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RNA6MS">
When speaking about his foreign policy views, Biden often says he sees the world locked in a struggle between democracies and autocracies. He wants to ensure democracies win.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8iR2aK">
“We have to prove democracy still works. That our government still works — and can deliver for the people,” he said during his <a href="https://www.vox.com/2021/4/28/22408735/joe-biden-congress-speech-democracy-autocracy">first address to Congress back in April</a>. Those who believe American democracy won’t prevail “are wrong, and we have to prove them wrong.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1N1UnB">
That’s why many see the passage of HR 1 as vital to Biden’s foreign policy; if it fails in Congress, it’ll be harder for Biden to push for a global democratic movement. After all, it’s awkward for any leader to tell others to push for democratic reforms while democracy dwindles in the country they lead.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Elie6o">
HR 1 is “probably the most important piece of legislation in terms of making sure we still have a democracy,” a senior Senate Democratic staffer told me, speaking on condition of anonymity because they were not authorized to speak publicly. “It’s trying to unrig the game.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Rx1U3E">
But there’s also a risk to Biden’s democracy vision if HR 1 actually makes it through Congress, Hurlburt told me. Republican-led states could slow-walk implementing many of the provisions in the bill. Such defiance might signal to other nations that the president can’t safeguard democracy in his own country, she said, which would be “terrible for all of US foreign policy, including the democracy agenda.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SML7wD">
Some analysts are less convinced that the bill will significantly affect voting rights in the US or American foreign policy writ large, though.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M29FuW">
Domestically, critics say the measures were <a href="https://www.politico.com/newsletters/playbook/2021/06/21/this-week-in-washington-biden-takes-on-rising-crime-493306">drafted by staffers, not true democratic reform experts</a>, well before the election issues of 2020 became apparent to all. As for the international part, some analysts believe HR 1 won’t be a turning point for America’s global relations.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JOogda">
“Foreign partners will not change their alignments based on the passage of this legislation,” said Justin Logan, a senior fellow at the CATO Institute in Washington. “Just as the contestation in the United States during the civil rights era did not tip the balance of power internationally, neither would restrictions on voting criteria in the states … affect the concrete realities of international politics.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tyYGA0">
Perhaps the bigger question is whether Biden is wise to have put so much stock in the global democracy agenda. While the <a href="https://www.vox.com/2021/5/3/22406391/hr1-poll-for-the-people-act">passage of HR 1 is popular</a>, a March poll from the Pew Research Center showed only <a href="https://www.pewresearch.org/fact-tank/2021/03/02/americans-put-low-priority-on-promoting-democracy-abroad-2/">20 percent</a> of US adults and 24 percent of Democrats and Democrat-leaning independents said promoting democracy in other nations should be a top priority as a long-range foreign policy goal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ghaFHO">
Getting HR 1 through Congress might be a worthy idea, but Biden’s emphasis on it could be a problem for his global designs. Should it fail, he’ll have a steeper climb to prove democracies right.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nP5RlU">
<em>Li Zhou and Ella Nilsen contributed to this report.</em>
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>WTC Final | Fifth day’s play starts after half an hour delay</strong> - Only 141.2 overs of play have been possible in the past four days due to rain and wet outfield.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Younis Khan steps down as Pakistan’s batting coach</strong> - The team will next go to the West Indies from July 21 to August 24 to feature in five T20Is and two Tests.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watch: Batsman’s big six smashes windscreen of his own car</strong> - British amateur cricketer Asif Ali’s huge heave backfired last weekend.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>WTC final | ICC should come up with formula to find winner in case of draw: Gavaskar</strong> - The ongoing match has been affected by English weather with the opening and fourth day washed out completely, while play has been disrupted frequently due to bad light.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Carl Nassib becomes first active NFL player to come out as gay</strong> - Nassib also announced a $100,000 donation to the Trevor Project, which works to prevent suicides among LGBTQ+ youth in America.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nitish Kumar leaves for Delhi amid speculations about JD(U) joining Union government</strong> - “I do not know why his Delhi tour is being linked to the proposed Cabinet reshuffle,” said Rajiv Ranjan Singh alias Lalan, one of the closest aides of Nitish Kumar.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sasikala criticises AIADMK leadership for “squandering” Rajya Sabha seat</strong> - Sasikala pointed out that there were several “senior and young” persons and any one of them could have been given the Rajya Sabha ticket.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>No balance doses of direct state procurement pending with Covid vaccine manufacturers: Government</strong> - An additional 8.8 lakh vaccine doses under the Centre’s procurement were provided to Delhi for free and more are in the pipeline, which will be supplied by June-end</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NIA court clears Akhil Gogoi of charges under UAPA in one case</strong> - NIA Special Judge Pranjal Das did not frame charges against Gogoi, who was arrested in December 2019, in connection with the case registered in the Chabua police station.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>University of Mysore may get coding academy modelled on Paris’s Ecole 42</strong> - An incubation centre focusing on start-ups in agriculture is also in the works</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Spain pardons Catalan leaders over independence bid</strong> - Nine separatists were jailed over a failed 2017 independence bid, but the pardons are controversial.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Roma street death was ‘No Czech Floyd’ say police</strong> - The Czech government backs police after a video shows an officer subduing a man by kneeling on his neck.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Euro 2020: Uefa declines request to light up Allianz Arena in rainbow colours</strong> - Uefa declines a request to light up the Allianz Arena in rainbow colours before Germany’s Euro 2020 match against Hungary on Wednesday.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A fairy tale in Denmark: How an unforgettable night unfolded in Copenhagen</strong> - How an emotional night in Copenhagen unfolded as Denmark reached the last 16 of Euro 2020.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Euro 2020: Wales fans ‘won’t be allowed in’ to Netherlands</strong> - Fans are told not to travel to Amsterdam for Wales’ Euro 2020 last 16 tie with Denmark.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Steven Spielberg’s production company signs multifilm deal with Netflix</strong> - Not long ago, Spielberg was trying to disqualify Netflix films from the Oscars. - <a href="https://arstechnica.com/?p=1775128">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amazon Prime Day 2021: All the deals that are actually worth your time [Updated]</strong> - Now updated with a “$50 for $40” gift card deal, OLED TV discounts, and more. - <a href="https://arstechnica.com/?p=1774658">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The ISRG wants to make the Linux kernel memory-safe with Rust</strong> - The simplest way to avoid C-language coding traps is to avoid coding in C. - <a href="https://arstechnica.com/?p=1775163">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Connecting to malicious Wi-Fi networks can mess with your iPhone</strong> - The world’s most secure consumer OS is bitten by a garden-variety programming bug. - <a href="https://arstechnica.com/?p=1775157">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Texans regret opting in to power plan that remotely raises thermostat temps</strong> - Some Texans who opted in to energy-saving plan didn’t realize what they agreed to. - <a href="https://arstechnica.com/?p=1775142">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>[Long] A lawyer married a woman who had previously divorced 10 husbands. On their wedding night, she told her new husband, "Please be gentle, I’m still a virgin</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A lawyer married a woman who had previously divorced 10 husbands. On their wedding night, she told her new husband, “Please be gentle, I’m still a virgin.” “What?” said the puzzled groom. “How can that be if you’ve been married 10 times?” "Well, Husband #1 was a sales representative. He kept telling me how great it was going to be. Husband #2 was in software services. He was never really sure how it was supposed to function, but he said he’d look into it and get back to me. Husband #3 was from field services. He said everything checked out diagnostically, but he just couldn’t get the system up. Husband #4 was in telemarketing. Even though he knew he had the order, he didn’t know when he would be able to deliver. Husband #5 was an engineer. He understood the basic process, but wanted three years to research, implement, and design a new state-of-the-art method. Husband #6 was from finance and administration. He thought he knew how, but he wasn’t sure whether it was his job or not. Husband #7 was in marketing. Although he had a nice product, he was never sure how to position it. Husband #8 was a psychologist. All he ever did was talk about it. Husband #9 was a gynecologist. All he did was look at it. Husband #10 was a stamp collector. All he ever did was… God! I miss him!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
But now that I’ve married you, I’m really excited!" “Good,” said the new husband, “but, why?” “You’re a lawyer. This time I know I’m going to get screwed!”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/randomguy2322"> /u/randomguy2322 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o577mi/long_a_lawyer_married_a_woman_who_had_previously/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o577mi/long_a_lawyer_married_a_woman_who_had_previously/">[comments]</a></span></p></li>
<li><strong>Two married buddies are out drinking one night…</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
when one turns to the other and says, “You know, I don’t know what else to do. Whenever I go home after we’ve been out drinking, I turn the headlights off before I get to the driveway. I shut off the engine and coast into the garage. I take my shoes off before I go into the house, I sneak up the stairs, I get undressed in the bathroom. I ease into bed and my wife STILL wakes up and yells at me for staying out so late!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His buddy looks at him and says, “Well, you’re obviously taking the wrong approach. I screech into the driveway, slam the door, storm up the steps, throw my shoes into the closet, jump into bed, rub my hands on my wife’s ass and say, ‘How about a blowjob?’ ….And she’s always sound asleep.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Wikydtron"> /u/Wikydtron </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o53iwi/two_married_buddies_are_out_drinking_one_night/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o53iwi/two_married_buddies_are_out_drinking_one_night/">[comments]</a></span></p></li>
<li><strong>A worldwide survey was conducted by the UN.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The only question asked was: “Would you please give your honest opinion about solutions to the food shortage in the rest of the world?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The survey was a huge failure.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In Africa they didn’t know what “food” meant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In Eastern Europe they didn’t know what “honest” meant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In Western Europe they didn’t know what “shortage” meant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In China they didn’t know what “opinion” meant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In the Middle East they didn’t know what “solution” meant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In South America they didn’t know what “please” meant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
And in the USA they didn’t know what “the rest of the world” meant.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/notriple"> /u/notriple </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o4uzra/a_worldwide_survey_was_conducted_by_the_un/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o4uzra/a_worldwide_survey_was_conducted_by_the_un/">[comments]</a></span></p></li>
<li><strong>I’m not a racist. I treat every race equally</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Even the bad ones
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/AcuriousPerson14"> /u/AcuriousPerson14 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o5atjk/im_not_a_racist_i_treat_every_race_equally/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o5atjk/im_not_a_racist_i_treat_every_race_equally/">[comments]</a></span></p></li>
<li><strong>What do you call a pig that is cold and growling?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A Ham-Brrr-Grrr.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I made this joke when I was 11. I remember being super proud lol.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/DinoAsh"> /u/DinoAsh </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o58uwm/what_do_you_call_a_pig_that_is_cold_and_growling/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o58uwm/what_do_you_call_a_pig_that_is_cold_and_growling/">[comments]</a></span></p></li>
</ul>
<script>AOS.init();</script></body></html>

4
index.html
View File

File diff suppressed because one or more lines are too long