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 <h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-preprints">From Preprints</a></li>
 <li><a href="#from-clinical-trials">From Clinical Trials</a></li>
 <li><a href="#from-pubmed">From PubMed</a></li>
 <li><a href="#from-patent-search">From Patent Search</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
 <ul>
 <li><strong>Values and well-being change amidst the COVID-19 pandemic in Poland</strong> -
 <div>
 COVID-19 caused a global change in the lifestyles of people around the world. It provided a unique opportunity to examine how external circumstances impact two crucial aspects of functioning relating to “who I am” (values) and “how I feel” (well-being). Participants (N = 150) reported their values, subjective and eduaimonic well-being nine months before lockdown in Poland, two weeks and four weeks into lockdown. We observed significant changes in values: an increase in self-direction, achievement, security, conformity, humility, benevolence and universalism, and a decrease in hedonism. All well-being indices showed a decrease in well-being with one specific difference between men and women: women experienced a more significant increase of negative affect compared to men. Finally, we showed that Openness to change values predict lower negative affect and higher eudaimonic well-being two weeks into lockdown. This study is unique in that it shows, that well-being and individually held values are flexible and adaptive systems that react to external circumstances, such as global critical events.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://psyarxiv.com/xr87s/" target="_blank">Values and well-being change amidst the COVID-19 pandemic in Poland</a>
 </div></li>
 <li><strong>The Social and Psychological Changes of the First Months of COVID-19</strong> -
 <div>
 The initial wave of the COVID-19 pandemic disrupted the lives of people across the globe. The current research sought to understand how the pandemic affected people’s social and psychological states during the first three months after the first U.S. death was reported. How did people’s emotions, thought patterns, and social lives change as the pandemic unfolded? The Reddit language of 200,000+ people across 18 cities in the U.S. was analyzed along with surveys from 11,000+ people in the U.S. and Canada. Overall, large psychological shifts were found that reflected three distinct phases. As the first COVID warnings emerged but prior to the shelter-in-place directives, people’s attentional focus switched to the impending threat. Anxiety levels surged, and positive emotion and anger dropped. In parallel, people’s thinking became more immediate and intuitive rather than analytic. When cities began lockdowns, anxiety levels spiked and sadness increased, and language shifted in ways that revealed people’s attempts to make sense of the situation. Six weeks after the onset, people’s psychological states stabilized but the COVID-produced changes had not abated. Converging evidence from survey responses and natural language analysis indicated that people’s ties with family strengthened but that social ties to broader groups (friends, city, and country) weakened. The psychological shifts were amplified on days when the country’s and cities’ COVID infection growth rates were higher, marking the link between the pandemic and the observed psychological patterns. Together, the study underscores the large psychological impacts across the country during the first three months of the crisis.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://psyarxiv.com/a34qp/" target="_blank">The Social and Psychological Changes of the First Months of COVID-19</a>
 </div></li>
 <li><strong>Imagination, anxiety, and loneliness during the COVID-19 pandemic.</strong> -
 <div>
 Imagination is relevant in many aspects of our lives, and has been associated with creativity and overall cognitive development, yet imagination may also have a dark side. In two studies we examined the link between imagination, anxiety, and loneliness during the COVID-19 pandemic. US college students (N = 101, Study 1) and participants from an international community sample (N = 61, Study 2) were tested around the time that rates of COVID-19 cases were escalating. Across both samples, we found that spending more time in one’s imagination was associated with elevated levels of anxiety. Furthermore, frequency of imagination interacted with loneliness in predicting changes in anxiety during, compared to before the pandemic. Specifically, lonely people who spent more time imagining experienced the largest increases in anxiety during, compared to before the pandemic. In Study 1 valence of imagination and changes in anxiety were also moderated by feelings of loneliness, although this effect was not replicated in Study 2. Results indicate that at least some features of imagination, particularly how much time people spend in imaginative states, may be associated with negative mood states, such as feelings of anxiety. Implications and future directions are discussed.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://psyarxiv.com/9aqbj/" target="_blank">Imagination, anxiety, and loneliness during the COVID-19 pandemic.</a>
 </div></li>
 <li><strong>Fluvastatin mitigates SARS-CoV-2 infection in human lung cells</strong> -
 <div>
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 Clinical data of patients suffering from COVID-19 have indicated that statin therapy, used to treat hypercholesterolemia, is associated with a better clinical outcome. We therefore investigated the effect of statins on SARS-CoV-2 infection in human lung cells and found that fluvastatin inhibited coronavirus infection, while other tested statins did not. Fluvastatin inhibited high and low pathogenic coronaviruses in vitro and ex vivo in a dose-dependent manner. Proteomic analyses of infected versus uninfected lung epithelial cells treated with fluvastatin, simvastatin, or rosuvastatin revealed that all tested statins modulated the cholesterol synthesis pathways without compromising the innate antiviral immune response. Strikingly, fluvastatin treatment uniquely affected the proteome of SARS CoV 2 infected cells, specifically downregulating proteins that modulate protein translation and viral replication. These results suggest that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that fluvastatin may have a moderate beneficial effect on SARS CoV-2 infection by modulating protein translation.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.07.13.20152272v4" target="_blank">Fluvastatin mitigates SARS-CoV-2 infection in human lung cells</a>
 </div></li>
 <li><strong>The SARS-CoV-2 antibody landscape is lower in magnitude for structural proteins, diversified for accessory proteins and stable long-term in children</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Background: Children are less clinically affected by SARS-CoV-2 infection than adults with the majority of cases being mild or asymptomatic and the differences in infection outcomes are poorly understood. The kinetics, magnitude and landscape of the antibody response may impact the clinical severity and serological diagnosis of COVID-19. Thus, a comprehensive investigation of the antibody landscape in children and adults is needed. Methods: We tested 254 plasma from 122 children with symptomatic and asymptomatic SARS-CoV-2 infections in Hong Kong up to 206 days post symptom onset, including 146 longitudinal samples from 58 children. Adult COVID-19 patients and pre-pandemic controls were included for comparison. We assessed antibodies to a 14-wide panel of SARS-CoV-2 structural and accessory proteins by Luciferase Immunoprecipitation System (LIPS). Findings: Children have lower levels of Spike and Nucleocapsid antibodies than adults, and their cumulative humoral response is more expanded to accessory proteins (NSP1 and Open Reading Frames (ORFs)). Sensitive serology using the three N, ORF3b, ORF8 antibodies can discriminate COVID-19 in children. Principal component analysis revealed distinct serological signatures in children and the highest contribution to variance were responses to non-structural proteins ORF3b, NSP1, ORF7a and ORF8. Longitudinal sampling revealed maintenance or increase of antibodies for at least 6 months, except for ORF7b antibodies which showed decline. It was interesting to note that children have higher antibody responses towards known IFN antagonists: ORF3b, ORF6 and ORF7a. The diversified SARS-CoV-2 antibody response in children may be an important factor in driving control of SARS-CoV-2 infection.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.03.21249180v2" target="_blank">The SARS-CoV-2 antibody landscape is lower in magnitude for structural proteins, diversified for accessory proteins and stable long-term in children</a>
 </div></li>
 <li><strong>Cohort Profile: A national prospective cohort study of SARS-CoV-2 pandemic outcomes in the U.S. - The CHASING COVID Cohort Study</strong> -
 <div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 <b>Purpose:</b> The CHASING COVID Cohort study is a U.S.-based prospective cohort study launched during the upswing of the U.S. COVID-19 epidemic. The objectives are to: 1) estimate and evaluate determinants of the cumulative incidence of SARS-CoV-2 infection, disease, and deaths; 2) assess the impact of the pandemic on psychosocial and economic outcomes; and 3) assess the uptake of pandemic mitigation strategies. <b>Participants:</b> We began enrolling participants March 28, 2020 using internet-based strategies. Adults &gt;=18 years residing anywhere in the U.S. or U.S. territories were eligible. 6,753 people are enrolled in the cohort, including participants from all 50 U.S. states, the District of Columbia, Puerto Rico, and Guam. Participants are contacted regularly to complete study assessments, including interviews and specimen collection. <b>Findings to date:</b> Of 4,247 participants who provided a specimen for baseline serologic testing, 135 were seropositive by screening antibody testing (3.2%, 95% CI 2.7%-3.5%) and 90 were seropositive by confirmatory antibody testing (2.1%, 95% CI 1.7%-2.6%). Cohort data have been used to assess the role of household crowding and the presence of children in the household as potential risk factors for severe COVID-19 early in the U.S. pandemic; to describe the prevalence of anxiety symptoms and its relationship to COVID-19 outcomes and other potential stressors; and to identify preferences for SARS-CoV-2 diagnostic testing when community transmission is on the rise via a discrete choice experiment. <b>Future plans:</b> The CHASING COVID Cohort Study has outlined a research agenda that involves ongoing monitoring of the cumulative incidence and determinants of SARS-CoV-2 outcomes, mental health outcomes and economic outcomes. Additional priorities include COVID-19 vaccine hesitancy, uptake and effectiveness; incidence, prevalence and correlates of long-haul COVID-19; and the extent and duration of the protective effect of SARS-CoV-2 antibodies.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.04.28.20080630v2" target="_blank">Cohort Profile: A national prospective cohort study of SARS-CoV-2 pandemic outcomes in the U.S. - The CHASING COVID Cohort Study</a>
 </div></li>
 <li><strong>The ancient cardioprotective mechanisms of ACE2 bestow SARS-CoV-2 with a wide host range</strong> -
 <div>
 SARS-CoV-2 infects a broader range of mammalian species than previously anticipated, suggesting there may be additional unknown hosts wherein the virus can evolve and potentially circumvent effective vaccines. We find that SARS-CoV-2 gains a wide host range by binding ACE2 sites essential for ACE2 carboxypeptidase activity. Six mutations found only in rodent species immune to SARS-CoV-2 are sufficient to abolish viral binding to human and dog ACE2. This is achieved through context-dependent mutational effects (intramolecular epistasis) conserved despite ACE2 sequence divergence between species. Across mammals, this epistasis generates sequence-function diversity, but through structures all bound by SARS-CoV-2. Mutational trajectories to the mouse conformation not bound by SARS-CoV-2 are blocked, by single mutations functionally deleterious in isolation, but compensatory in combination, explaining why human polymorphisms at these sites are virtually non-existent. Closed to humans, this path was opened to rodents via permissive cardiovascular phenotypes and ancient increases to ACE2 activity, serendipitously granting SARS-CoV-2 immunity. This reveals how ancient evolutionary trajectories are linked with unprecedented phenotypes such as COVID-19 and suggests extreme caution should be taken to monitor and prevent emerging animal reservoirs of SARS-CoV-2.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.03.425115v1" target="_blank">The ancient cardioprotective mechanisms of ACE2 bestow SARS-CoV-2 with a wide host range</a>
 </div></li>
 <li><strong>Spike protein disulfide disruption as a potential treatment for SARS-CoV-2</strong> -
 <div>
 The coronaviral pandemic is exerting a tremendously detrimental impact on global health, quality of life and the world economy, emphasizing the need for effective medications for current and future coronaviral outbreaks as a complementary approach to vaccines. The Spike protein, responsible for cell receptor binding and viral internalization, possesses multiple disulfide bonds raising the possibility that disulfide-reducing agents might disrupt Spike function, prevent viral entry and serve as effective drugs against SARS-CoV-2. Here we show the first experimental evidence that reagents capable of reducing disulfide bonds can inhibit viral infection in cell-based assays. Molecular dynamics simulations of the Spike receptor-binding domain (RBD) predict increased domain flexibility when the four disulfide bonds of the domain are reduced. This flexibility is particularly prominent for the surface loop, comprised of residues 456-490, which interacts with the Spike cell receptor ACE2. Consistent with this finding, the addition of exogenous disulfide bond reducing agents affects the RBD secondary structure, lowers its melting temperature from 52 to 36-39 degrees Celsius and decreases its binding affinity to ACE2 by two orders of magnitude at 37C. Finally, the reducing agents dithiothreitol (DTT) and tris(2-carboxyethyl)phosphine (TCEP) inhibit viral replication at high microM - low milliM levels with a negligible effect on cell viability at these concentrations. The antiviral effect of monothiol-based reductants N-Acetyl-L-cysteine (NAC) and reduced glutathione (GSH) was not observed due to decreases in cell viability. Our research demonstrates the clear potential for medications that disrupt Spike disulfides as broad-spectrum anticoronaviral agents and as a first-line defense against current and future outbreaks.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.02.425099v1" target="_blank">Spike protein disulfide disruption as a potential treatment for SARS-CoV-2</a>
 </div></li>
 <li><strong>Structure-function investigation of a new VUI-202012/01 SARS-CoV-2 variant</strong> -
 <div>
 The SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus) has accumulated multiple mutations during its global circulation. Recently, a new strain of SARS-CoV-2 (VUI 202012/01) had been identified leading to sudden spike in COVID-19 cases in South-East England. The strain has accumulated 23 mutations which have been linked to its immune evasion and higher transmission capabilities. Here, we have highlighted structural-function impact of crucial mutations occurring in spike (S), ORF8 and nucleocapsid (N) protein of SARS-CoV-2. Some of these mutations might confer higher fitness to SARS-CoV-2.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.01.425028v1" target="_blank">Structure-function investigation of a new VUI-202012/01 SARS-CoV-2 variant</a>
 </div></li>
 <li><strong>Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck</strong> -
 <div>
 The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts and, potentially, undergo antigenic evolution depend on the ways genetic variation is generated and selected within and between individual hosts. Using domestic cats as a model, we show that SARS-CoV-2 consensus sequences remain largely unchanged over time within hosts, while dynamic sub-consensus diversity reveals processes of genetic drift and weak purifying selection. We further identify a notable variant at amino acid position 655 in Spike (H655Y), which was previously shown to confer escape from human monoclonal antibodies. This variant arises rapidly and persists at intermediate frequencies in index cats. It also becomes fixed following transmission in two of three pairs. These dynamics suggest this site may be under positive selection in this system and illustrate how a variant can quickly arise and become fixed in parallel across multiple transmission pairs. Transmission of SARS-CoV-2 in cats involved a narrow bottleneck, with new infections founded by fewer than ten viruses. In RNA virus evolution, stochastic processes like narrow transmission bottlenecks and genetic drift typically act to constrain the overall pace of adaptive evolution. Our data suggest that here, positive selection in index cats followed by a narrow transmission bottleneck may have instead accelerated the fixation of S H655Y, a potentially beneficial SARS-CoV-2 variant. Overall, our study suggests species- and context-specific adaptations are likely to continue to emerge. This underscores the importance of continued genomic surveillance for new SARS-CoV-2 variants as well as heightened scrutiny for signatures of SARS-CoV-2 positive selection in humans and mammalian model systems.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.11.16.384917v2" target="_blank">Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck</a>
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 <li><strong>Remdesivir and Lopinavir/Ritonavir as Potential Drugs to Treat Corona Virus Disease 2019</strong> -
 <div>
 Drugs that are efficacious against SARS-CoV-2 have yet to be established. Remdesivir and Lopinavir/ritonavir have garnered considerable attention for their potential to treat coronavirus disease 2019 (COVID-19). Remdesivir not only in vivo but also in vitro testing shows the inhibition of human coronavirus replication, including SARS-CoV as well as Lopinavir/ritonavir that shows promising antiviral drug against SARS-CoV-2.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://osf.io/e6cz5/" target="_blank">Remdesivir and Lopinavir/Ritonavir as Potential Drugs to Treat Corona Virus Disease 2019</a>
 </div></li>
 <li><strong>Do Chloroquine and Hydroxychloroquine Treat COVID-19?</strong> -
 <div>
 Chloroquine is an anti-malarial and autoimmune disease drug, which has an anti- viral activity. In vitro, the Chloroquine and Hydroxychloroquine are potent at inhibiting SARS-CoV. Therefore, Chloroquine and Hydroxychloroquine are being studied for their potential treatment of coronavirus disease 2019. Those drugs are now recommended by the FDA, and multiple health organizations. This aims of this review is to explore the efficacy of the chloroquine and hydrochloroquine in the treatment of the novel COVID-19.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://thesiscommons.org/jrhf9/" target="_blank">Do Chloroquine and Hydroxychloroquine Treat COVID-19?</a>
 </div></li>
 <li><strong>Evidence for a Connection Between COVID-19 and Exposure to Radiofrequency Radiation from Wireless Telecommunications Including Microwaves and Millimeter Waves</strong> -
 <div>
 COVID-19 public health policy has focused on the SARS-CoV-2 virus and its effects on human health while environmental factors have been largely ignored. In considering the epidemiological triad (agent-host-environment) applicable to all disease, we investigated a possible environmental factor in the COVID-19 pandemic: ambient radiofrequency radiation from wireless communication systems including microwaves and millimeter waves. COVID-19 surfaced in Wuhan, China shortly after the implementation of city-wide 5G (fifth generation of wireless radiation), and spread globally, demonstrating a statistical correlation to international communities with 5G antennas installed. In this study, we examined the peer-reviewed scientific literature on the detrimental bioeffects of radiofrequency radiation (RFR) and identified several ways in which RFR may be contributing to COVID-19 as a toxic environmental cofactor. We conclude that RFR and, in particular, 5G, which involves 4G infrastructure densification, has exacerbated COVID-19 prevalence and severity by weakening host immunity and increasing SARS-CoV-2 virulence by (1) causing morphologic changes in erythrocytes including echinocyte and rouleaux formation that may be contributing to hypercoagulation; (2) impairing microcirculation and reducing erythrocyte and hemoglobin levels exacerbating hypoxia; (3) amplifying immune system dysfunction, including immunosuppression, autoimmunity, and hyperinflammation; (4) increasing cellular oxidative stress and the production of free radicals exacerbating vascular injury and organ damage; (5) augmenting intracellular Ca2+ essential for viral entry, replication, and release, in addition to promoting pro-inflammatory pathways; and (6) worsening heart arrhythmias and cardiac disorders. In short, RFR is a ubiquitous environmental stressor that contributes to adverse health outcomes of COVID-19. We invoke the Precautionary Principle and strongly recommend a moratorium on 5G wireless infrastructure at this crucial time to help mitigate the pandemic, and to preserve public health until governmental safety standards for RFR exposure based on current and future research are defined and employed.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://osf.io/9p8qu/" target="_blank">Evidence for a Connection Between COVID-19 and Exposure to Radiofrequency Radiation from Wireless Telecommunications Including Microwaves and Millimeter Waves</a>
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 <li><strong>Brazilian model estimation for SARS-CoV-2 peak contagion (BMESPC): first and second wave</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 With newer data for SARS-CoV-2 and entering the second wave of contagion required the improvement of the forecasting model, structuring its model to forecast the peak of the first and second contagion wave in Brazil. The Brazilian model estimation for SARS-CoV-2 peak contagion (BMESPC) was structured, capable of estimating the peak of contagion for SARS-CoV-2 in the first and second waves, as the main objective of this work. Using the BMESPC model, it was possible to estimate, with a certain reliability degree, the peak of contagion for the first and second waves in Brazil, with one day difference from the real to the forecast. While at the state level, the calculated confidence interval proved to be more accurate. In this way, it is possible to use BMESPC to forecast the peak of contagion for several regions, provided that the necessary structure and calibration are respected.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.02.20248940v2" target="_blank">Brazilian model estimation for SARS-CoV-2 peak contagion (BMESPC): first and second wave</a>
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 <li><strong>Oxygen saturation instability in suspected covid-19 patients; contrasting effects of reduced VA/Q and shunt.</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Patients in the UK at risk of Covid-19 pneumonia, but not needing immediate hospital attention, are to be given pulse oximeters to identify a fall in oxygen saturation (SaO2 or SpO2) at home. A recent finding in Covid-19 pneumonia is a dominant reduction in ventilation to perfused alveoli (VA/Q). A mathematical model of gas exchange was used to predict the effect of shunt or reduced VA/Q on SaO2 stability inferred from the slope of the PIO2 vs SaO2 curve as it intersected the line representing ambient PIO2. A ±1 kPa variation in PIO2 predicted a 1.5% and 8% change in SpO2 with 15% shunt and 0.4 VA/Q respectively. As a consistency check, two patients with pre-existing lung disease and 12 hour continuous SpO2 monitoring breathing air had gas exchange impairment analysed in terms of shunt and reduced VA/Q. The patient with 16% shunt and normal VA/Q had a stable but reduced SpO2 (circa 93±1%) throughout the 12 hr period. The patient with a VA/Q reduced to 0.48 had SpO2 ranging from 75-95% during the same period. SpO2 monitoring in suspected covid-19 patients should focus on SpO2 varying &gt;5% in 30 minutes. Such instability in at risk patients is not diagnostic of Covid -19 pneumonia but this may be suspected from a dominant reduction in VA/Q if episodic hypoxaemia has progressed from a stable SpO2. Key words. Covid-19, Respiratory Measurement, Pneumonia, ARDS, VA/Q, Shunt, Oxygen Saturation.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.17.20248126v2" target="_blank">Oxygen saturation instability in suspected covid-19 patients; contrasting effects of reduced VA/Q and shunt.</a>
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 <h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dendritic Cell Vaccine to Prevent COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: AV-COVID-19<br/><b>Sponsors</b>:   Indonesia-MoH;   Aivita Biomedical, Inc.;   PT AIVITA Biomedika Indonesia;   National Institute of Health Research and Development, Ministry of Health Republic of Indonesia;   RSUP Dr. Kariadi Semarang, indonesia;   Faculty of Medicine University of Diponegoro, Indonesia<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Anakinra;   Drug: Placebo<br/><b>Sponsor</b>:   Hellenic Institute for the Study of Sepsis<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating the Impact of EnteraGam In People With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: Bovine Plasma-Derived Immunoglobulin Concentrate;   Other: Standard of care<br/><b>Sponsors</b>:   Entera Health, Inc;   Lemus Buhils, SL;   Clinical Research Unit, IMIM (Hospital del Mar Medical Research Institute)<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Remdesivir and Tociluzumab for the Management of Severe COVID-19: A Randomized Controlled Trial</strong> - <b>Conditions</b>:   Covid19;   Covid-19 ARDS<br/><b>Interventions</b>:   Drug: Remdesivir;   Drug: Tocilizumab<br/><b>Sponsors</b>:   M Abdur Rahim Medical College and Hospital;   First affiliated Hospital of Xi'an Jiaoting University<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhaled Ivermectin and COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ivermectin Powder<br/><b>Sponsor</b>:   Mansoura University<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Tenofovir/Emtricitabine in Patients Recently Infected With SARS-COV2 (Covid-19) Discharged Home</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: tenofovir disoproxil and emtricitabine<br/><b>Sponsor</b>:   University Hospital, Caen<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Two Different Strengths of the Inactivated COVID-19 Vaccine ERUCOV-VAC</strong> - <b>Condition</b>:   COVID-19 Vaccine<br/><b>Interventions</b>:   Biological: ERUCOV-VAC;   Other: Placebo Vaccine<br/><b>Sponsors</b>:   Health Institutes of Turkey;   TC Erciyes University<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AZD1222 Vaccine in Combination With rAd26-S (Component of Gam-COVID-Vac Vaccine) for the Prevention of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AZD1222;   Biological: rAd26-S<br/><b>Sponsors</b>:   AstraZeneca;   R-Pharm;   The Russian Direct Investment Fund (RDIF);   The Gamaleya National Center of Epidemiology &amp; Microbiology<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Ramdicivir and Baricitinib for the Treatment of Severe COVID 19 Patients</strong> - <b>Conditions</b>:   Covid19;   Covid-19 ARDS<br/><b>Interventions</b>:   Drug: Remdesivir;   Drug: Baricitinib;   Drug: Tocilizumab<br/><b>Sponsors</b>:   M Abdur Rahim Medical College and Hospital;   First affiliated Hospital Xi'an Jiaoting University<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti-COVID19 AKS-452 - ACT Study</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: AKS-452<br/><b>Sponsors</b>:   University Medical Center Groningen;   Akston Biosciences Corporation<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AZD1222;   Biological: rAd26-S<br/><b>Sponsors</b>:   R-Pharm;   AstraZeneca<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Surgical Face Mask Effects in Patients With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Sit-To-Stand test<br/><b>Sponsor</b>:   Cliniques universitaires Saint-Luc- Université Catholique de Louvain<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Favipiravir in Treatment of Mild &amp; Moderate COVID-19 Infection in Nepal</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Favipiravir;   Drug: Placebo;   Drug: Remdesivir<br/><b>Sponsor</b>:   Nepal Health Research Council<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dendritic Cell Vaccine, AV-COVID-19, to Prevent COVID-19 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AV-COVID-19;   Other: GM-CSF<br/><b>Sponsors</b>:   Aivita Biomedical, Inc.;   PT AIVITA Biomedika Indonesia;   Indonesia Ministry of Health;   National Institute of Health Research and Development, Ministry of Health Republic of Indonesia<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase II Study to Evaluate MVC-COV1901 Vaccine Against SARS-CoV-2 in Adult</strong> - <b>Condition</b>:   Covid19 Vaccine<br/><b>Interventions</b>:   Biological: MVC-COV1901(S protein with adjuvant);   Biological: MVC-COV1901(Saline)<br/><b>Sponsor</b>:   Medigen Vaccine Biologics Corp.<br/><b>Recruiting</b></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-CoV-2 and SARS-CoV</strong> - COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China. The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74% identity and use similar mechanisms to gain entry into the cell. Both the viruses enter the host cell by binding of the viral spike glycoprotein to the host receptor, angiotensin converting enzyme 2 (ACE2). Targeting entry of the virus has a better advantage than inhibiting the later stages of the viral life cycle. The crystal structure of...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular mechanism of inhibition of COVID-19 main protease by beta-adrenoceptor agonists and adenosine deaminase inhibitors using in silico methods</strong> - Novel coronavirus (COVID-19) responsible for viral pneumonia which emerged in late 2019 has badly affected the world. No clinically proven drugs are available yet as the targeted therapeutic agents for the treatment of this disease. The viral main protease which helps in replication and transcription inside the host can be an effective drug target. In the present study, we aimed to discover the potential of β-adrenoceptor agonists and adenosine deaminase inhibitors which are used in asthma and...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential Medicinal Plants for the Treatment of Dengue Fever and Severe Acute Respiratory Syndrome-Coronavirus</strong> - While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Role of Host-Mediated Post-Translational Modifications (PTMs) in RNA Virus Pathogenesis</strong> - Being opportunistic intracellular pathogens, viruses are dependent on the host for their replication. They hijack host cellular machinery for their replication and survival by targeting crucial cellular physiological pathways, including transcription, translation, immune pathways, and apoptosis. Immediately after translation, the host and viral proteins undergo a process called post-translational modification (PTM). PTMs of proteins involves the attachment of small proteins,...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-beta Production</strong> - SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus infection. In this study, we discovered that the nucleocapsid (N) protein of SARS-CoV-2 plays an important role in the inhibition of interferon beta (IFN-β) production. N protein repressed IFN-β production induced by poly(I:C) or upon Sendai virus (SeV) infection. We noted that N protein also suppressed IFN-β production,...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity</strong> - P-selectin glycoprotein ligand-1 (PSGL-1) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into inflamed tissues. PSGL-1 has been identified as an interferon-γ (INF-γ)-regulated factor that restricts HIV-1 infectivity, and has recently been found to possess broad-spectrum antiviral activities. Here we report that the expression of PSGL-1 in virus-producing cells impairs...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Interactions of Nintedanib and Oral Anticoagulants-Molecular Mechanisms and Clinical Implications</strong> - Nintedanib is a synthetic orally active tyrosine kinase inhibitor, whose main action is to inhibit the receptors of the platelet-derived growth factor, fibroblast growth factor and vascular endothelial growth factor families. The drug also affects other kinases, including Src, Flt-3, LCK, LYN. Nintedanib is used in the treatment of idiopathic pulmonary fibrosis, chronic fibrosing interstitial lung diseases and lung cancer. The mechanism of action suggests that nintedanib should be considered one...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hydroxychloroquine as a Chemoprophylactic Agent for COVID-19: A Clinico-Pharmacological Review</strong> - Hydroxychloroquine has gained much attention as one of the candidate drugs that can be repurposed as a prophylactic agent against SARS-CoV-2, the agent responsible for the COVID-19 pandemic. Due to high transmissibility and presence of asymptomatic carriers and presymptomatic transmission, there is need for a chemoprophylactic agent to protect the high-risk population. In this review, we dissect the currently available evidence on hydroxychloroquine prophylaxis from a clinical and...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2</strong> - Outbreak of coronavirus disease 2019 occurred in Wuhan and has rapidly spread to almost all parts of world. GB-1, the herbal formula from Tian Shang Sheng Mu of Chiayi Puzi Peitian Temple, is used for the prophylaxis of SARS-CoV-2 in Taiwan. In this study, we investigated that the effect of GB-1 and the index compounds of GB-1 on the ACE2 and TMPRSS2 expression through in vitro and in vivo study. In our result, GB-1 can inhibit ACE2 and TMPRSS2 protein expression in HepG2 cells, 293T cells, and...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Excited-state electronic properties, structural studies, noncovalent interactions, and inhibition of the novel severe acute respiratory syndrome coronavirus 2 proteins in Ripretinib by first-principle simulations</strong> - Ripretinib is a recently developed drug for the treatment of adults with advanced gastrointestinal stromal tumors. This paper reports an attempt to study this molecule by electronic modeling and molecular mechanics to determine its composition and other specific chemical features via the density-functional theory (DFT), thereby affording sufficient information on the electronic properties and descriptors that can enable the estimation of its molecular bioactivity. We explored most of the...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses</strong> - A series of 7-deazaadenine ribonucleosides bearing alkyl, alkenyl, alkynyl, aryl, or hetaryl groups at position 7 as well as their 5'-O-triphosphates and two types of monophosphate prodrugs (phosphoramidates and S-acylthioethanol esters) were prepared and tested for antiviral activity against selected RNA viruses (Dengue, Zika, tick-borne encephalitis, West Nile, and SARS-CoV-2). The modified triphosphates inhibited the viral RNA-dependent RNA polymerases at micromolar concentrations through the...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site</strong> - Coronavirus entry is mediated by the spike protein which binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines and it is currently unclear which proteases are relevant in vivo. A remarkable feature of the SARS-CoV-2 spike is the presence of a multibasic cleavage site (MBCS), which is absent in the SARS-CoV spike. Here, we report that the SARS-CoV-2 spike MBCS increases infectivity on human airway organoids (hAOs)....</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study</strong> - Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synthesis of novel indolo[3,2-c]isoquinoline derivatives bearing pyrimidine, piperazine rings and their biological evaluation and docking studies against COVID-19 virus main protease</strong> - A series of hybrid indolo[3,2-c]isoquinoline (δ-carboline) analogs incorporating two pyrimidine and piperizine ring frameworks were synthesized. Intending biological activities and SAR we propose replacements of fluorine, methyl and methoxy of synthetic compounds for noteworthy antimicrobial, antioxidant, anticancer and anti-tuberculosis activities. Among these compounds 3a, 4a and 5e were progressively strong against E. coli and K. pneumonia. Whereas, compounds 4a, 5a and 6a with addition of...</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tetracycline plus macrolide: A potential therapeutic regimen for COVID-19?</strong> - The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that struck in late 2019 and early 2020 is a serious threat to human health. Since there are no approved drugs that satisfactorily treat this condition, all efforts at drug design and/or clinical trials are warranted and reasonable. Drug repurposing is a well-known strategy that seeks to deploy existing licensed drugs for newer indications and that provides the quickest possible transition from the bench...</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid 19 - Chewing Gum</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313269181">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313300659">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19</strong> - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN313339294">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251184">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251182">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN312324209">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물</strong> - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR313434044">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU311608060">link</a></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mundschutz für Brillenträger und Brillenadapter</strong> -
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 </p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Mundschutz bestehend aus einem Abdeckteil für den Mund- und gegebenenfalls den Nasenbereich des Gesichts und einem Bandteil mit mindestens einem Halteband, welches mit den Seiten des Abdeckteil verbunden ist und zur Befestigung des Mundschutzes dient, wobei das Halteband am seitlichen Ende des Abdeckteils fixiert ist und eine Schlaufe bildet, dadurch gekennzeichnet, dass an der Schlaufe des Haltebands ein Clip befestigt ist.</p></li>
 </ul>
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 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313866570">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 RBD共轭纳米颗粒疫苗</strong> - 本发明涉及免疫医学领域，具体而言，涉及一种SARS‑CoV‑2 RBD共轭纳米颗粒疫苗。该疫苗包含免疫原性复合物，所述免疫原性复合物包含：a）与SpyCatcher融合表达的载体蛋白自组装得到的纳米颗粒载体；b）与SpyTag融合表达的SARS‑CoV‑2病毒的RBD抗原；所述载体蛋白选自Ferritin、mi3和I53‑50；所述载体蛋白与所述抗原之间通过SpyCatcher‑SpyTag共价连接。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN313355625">link</a></p></li>
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 <h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-new-yorker">From New Yorker</a></li>
 <li><a href="#from-vox">From Vox</a></li>
 <li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
 <li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
 <li><a href="#from-bbc-europe">From BBC: Europe</a></li>
 <li><a href="#from-ars-technica">From Ars Technica</a></li>
 <li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump’s Authoritarian Moment Is Here</strong> - Far too many Republicans are complicit in the President’s continuing efforts to overturn the election results. - <a href="https://www.newyorker.com/news/our-columnists/trumps-authoritarian-moment-is-here">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What the San Francisco Bay Area Can Teach Us About Fighting a Pandemic</strong> - The region’s hyper-local response has lessons for us as we confront the winter wave and begin to distribute vaccines. - <a href="https://www.newyorker.com/news/california-chronicles/what-the-san-francisco-bay-area-can-teach-us-about-fighting-a-pandemic">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Congressional Republicans Could Sabotage the Counting of Electoral Votes</strong> - This week is the true test of elected officials’ commitment to democracy. - <a href="https://www.newyorker.com/news/our-columnists/trump-and-republicans-in-congress-could-still-jeopardize-the-election">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inside the U.S. Army’s Warehouse Full of Nazi Art</strong> - One of the world’s largest collections of Nazi propaganda is housed at Fort Belvoir, in northern Virginia; much of it is virulent, and most of it is never seen by the public. - <a href="https://www.newyorker.com/news/news-desk/inside-the-us-armys-warehouse-full-of-nazi-art">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can Boosting Child and Elder Care Help Democrats Win Control of the Senate?</strong> - Groups canvassing in Georgia say that the “care economy” is a pivotal issue to voters. - <a href="https://www.newyorker.com/news/campaign-chronicles/can-boosting-child-and-elder-care-help-democrats-win-control-of-the-senate">link</a></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-vox">From Vox</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why anyone could win Georgia’s runoff elections, according to the polls</strong> -
 <figure>
 <img alt="Warnock appears in a suit without a tie on a giant flatscreen that towers above a row of cars. In the foreground, presumably perched on the roof of a car, is a masked Black man with grey hair holding a blue sign that says in white letters, “New Year New Senate Make A Plan.”" src="https://cdn.vox-cdn.com/thumbor/8vwFK_IPu6s1_2MOsKCEfftBKqA=/333x0:3000x2000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68621198/GettyImages_1294346642.0.jpg"/>
 <figcaption>
 Supporters listen to Rev. Raphael Warnock campaign in Savannah, Georgia, on January 3. | Michael M. Santiago/Getty Images
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Ahead of the race, polls show both Senate races are very close.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lugUxT">
 If Democrats Jon Ossoff and Rev. Raphael Warnock win their races in <a href="https://www.vox.com/2021/1/4/22204765/stakes-georgia-senate-runoff-elections-stakes">Georgia’s Senate runoffs</a>, Democrats will control both Congress and the White House. According to the polls, the two candidates have an about even chance of defeating Republican incumbent Sens. David Perdue and Kelly Loeffler.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="n25YIe">
 The extended races began following Election Day on November 3, when it became clear no candidate had cleared the <a href="https://www.vox.com/21571755/georgia-senate-runoffs-9-questions">50 percent threshold</a> Georgia requires to avoid runoffs. And throughout this period — aside from a few outliers taken in December that showed decisive leads for either the Democrats or the Republicans — pollsters have found the elections to be quite close.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Yy5Zv">
 The most recent polls reflect this trend.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TRtiZc">
 For instance, a <a href="https://www.pollsmartmr.com/latest-polls-1/poll-the-georgia-runoffs-are-a-dead-heat">Targoz Market Research</a> poll taken from December 30 to January 3, of 713 likely voters, found Ossoff and Perdue to be tied in their race, each receiving 50 percent support, and Warnock to have a 2 percentage point lead (51 percent to 48 percent support) over Loeffler. A <a href="https://busr.ag/georgia-senate-poll">BUSR/University of Nevada Las Vegas</a> poll taken during the same time frame, of 550 likely voters, saw a similar result: Perdue and Loeffler both leading by 1 percentage point.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sV1zfb">
 <a href="https://projects.fivethirtyeight.com/georgia-senate-polls/">FiveThirtyEight’s polling averages</a>, which collate all polls taken since the runoff elections began (and are adjusted in an attempt to correct for polling firm differences and biases) show Ossoff leading Perdue by 1.4 percentage points, and Warnock ahead of Loeffler by 2 percentage points.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ySkzRy">
 Warnock looks to have perhaps a slightly better chance of defeating Loeffler than Ossoff does besting Perdue — perhaps in part because Perdue won his seat in an election before, while Loeffler was only recently appointed, after Johnny Isakson retired in 2019. The bigger question is how much polls can tell us about who will be Georgia’s senators in the 117th Congress.
 </p>
 <h3 id="jNqt7u">
 2020 polls didn’t clearly reflect the results of the presidential election
 </h3>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VQF0kf">
 In general, it’s important to remember that polls reflect a moment in time and an estimated sample of voters, which may not hold true in election results. Some of those surveyed might not make it to the polls, for example, or late-breaking news might alter voters’ feelings about the candidates.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tUygIc">
 The most recent Georgia polls, however, reflect a period directly before Election Day — there has been little time for much to change; and many Georgians have already voted: The state had an <a href="https://sos.ga.gov/admin/files/2020%20Revised%20Short%20Calendar.pdf">extended early voting period</a>, running from December 14 to 31 (with <a href="https://www.wtoc.com/2020/12/31/last-day-early-voting-ga-runoff-elections/">absentee ballots</a> accepted at drop boxes until 7 pm ET on January 5). More than 3 million people cast their ballots before Election Day (4.9 million Georgians voted in the November election).
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="geL5GF">
 Many states, Georgia included, had similar early voting periods ahead of the 2020 general election — and many polls were taken in the days just before November 3. These polls still failed to provide an accurate picture of the electorate, with the final results being radically different in some cases.
 </p>
 <figure class="e-image">
 <pre><code>    &lt;img alt="Biden, in a navy sportscoat and blue slacks, waves while standing between — and six feet from — Warnock and Ossoff. All three have on masks; Warnock and Ossoff both have on dark suits with blue ties. The three men are on a stage, outside, set up in front of an industrial building that’s decorated with US and Georgia state flags." src="https://cdn.vox-cdn.com/thumbor/HrRES0_hkm85LbX7dCQMGHa2smg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22213320/GettyImages_1230145021.jpg" /&gt;
  &lt;cite&gt;Drew Angerer/Getty Images&lt;/cite&gt;
  &lt;figcaption&gt;President-elect Joe Biden campaigns in Atlanta, Georgia for Democratic Senate candidates Rev. Raphael Warnock and Jon Ossoff.&lt;/figcaption&gt;</code></pre>
 </figure>
 <figure class="e-image">
 <pre><code>    &lt;img alt="Loeffler, in a red puffer coat and dark blue denim shirt, stands behind a podium featuring the seal of the president of the US; surrounded by a crowd of Trump supporters, she speaks into a microphone. To her right, Trump and Purdue, both in dark overcoats, smile as they listen to her remarks." src="https://cdn.vox-cdn.com/thumbor/VLoxbKek3AIokNutQ9tcPuEZ1BU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22213321/GettyImages_1289647400.jpg" /&gt;
  &lt;cite&gt;Spencer Platt/Getty Images&lt;/cite&gt;
  &lt;figcaption&gt;President Trump campaigns for Sens. David Perdue and Kelly Loeffler in Valdosta, Georgia.&lt;/figcaption&gt;</code></pre>
 </figure>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yUAVek">
 Most polls showed President-elect Joe Biden would win, and he did. At both the state and <a href="https://projects.fivethirtyeight.com/polls/president-general/national/">national</a> levels, however, the polls often overrepresented his level of support.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nHcQSn">
 The Georgia polls were fairly close to the end results, but still overestimated Biden’s chances a bit: <a href="https://projects.fivethirtyeight.com/polls/president-general/georgia/">FiveThirtyEight’s polling average</a> found Biden with a 1.2 percentage point lead over President Donald Trump. In reality, the president-elect won with a 0.25 percentage point advantage, according to <a href="https://www.vox.com/21551099/trump-biden-georgia-vox-live-results">Decision Desk HQ</a>.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0NfE3z">
 Polling-based predictions in other states were further off; as <a href="https://www.vox.com/policy-and-politics/2020/11/10/21551766/election-polls-results-wrong-david-shor">Vox’s Dylan Matthews</a> noted shortly after the election, “In the Maine Senate race, <a href="https://projects.fivethirtyeight.com/2020-election-forecast/senate/maine/"><strong>FiveThirtyEight</strong></a> estimated that Democrat Sara Gideon would beat Republican incumbent Susan Collins by 2 points; <a href="https://results.decisiondeskhq.com/2020/general/maine"><strong>Gideon lost by 9 points</strong></a>, an 11-point miss.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3jQcVt">
 There was a similar divide, particularly with respect to state polling, following the 2016 presidential election. As <a href="https://www.vox.com/21538156/biden-polls-lead-election-trump-2020-2016">Matt Yglesias explained for Vox</a>, pollsters worked to correct that by refining the models they used, and by <a href="https://www.vox.com/policy-and-politics/2019/11/14/20961794/education-weight-state-polls-trump-2020-election">beginning to weight</a> — or adjust their samples — based on respondent’s education level.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1DoJCk">
 But as <a href="https://www.vox.com/policy-and-politics/2020/11/10/21551766/election-polls-results-wrong-david-shor">Matthews has explained</a>, these corrections ended up not solving the problem — in 2020, polls were still off. Matthews asked political data analyst David Shor why this was, and Shor posited an issue of social trust:
 </p>
 <blockquote>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FQl8rV">
 It used to be that once you control for age and race and gender and education, that people who trusted their neighbors basically voted the same as people who didn’t trust their neighbors. But then, starting in 2016, suddenly that shifted. If you look at white people without college education, high-trust non-college whites tended toward [Democrats], and low-trust non-college whites heavily turned against us. In 2016, we were polling this high-trust electorate, so we overestimated Clinton. These low-trust people still vote, even if they’re not answering these phone surveys.
 </p>
 </blockquote>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KgR3V2">
 Those more willing to trust strangers are more willing to participate in polls, Shor said his research has found, meaning polls oversample Democrats and undersample Republicans in a way that’s difficult to control for. Furthermore, he told Matthews, Democrats have become more politically engaged in recent months due to factors ranging from the pandemic to the civil rights movement; this has led to an increased willingness — particularly among liberal Democrats — to answer pollsters’ questions.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wVZArL">
 So Democrats may be generally overrepresented in polls. And liberal Democrats may have an outsized weight on the results, inflating the support of Democratic candidates that, in reality, may not even have the firm support of the Democratic base.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4bOth3">
 It’s not clear much has changed in survey sampling since November, and Georgia polls weren’t too far off then. Should there be a similar divergence between FiveThirtyEight’s current runoff polling averages and the final results, Ossoff and Warnock would win their races narrowly; a slightly larger difference — of about 0.5 percentage points in Ossoff’s case — would mean wins for Purdue and Loeffler.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CJT5EV">
 Still, there’s reason to believe that in the latest Georgia polls, Ossoff and Warnock may not have the support they appear to have, and that their slim polling average leads might actually be deficits. And in a close race, even a normal polling error could miss the election winner.
 </p>
 <h3 id="WHBSsR">
 There are some other factors complicating Georgia polling — and predicting who will win the elections
 </h3>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DODuv3">
 Many pollsters appeared to run into trouble overestimating support for Democrats; and this, in turn, affected polling averages. Averages were helped in the general election by the number of pollsters providing data; but there are far fewer providing data points for the Georgia special election, giving each poll that is released greater weight in averages like FiveThirtyEight’s. If one of these polls is far off, the error will have an outsized effect on the overall average.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4hh9eR">
 Further raising questions about the accuracy of the average is the fact that many of the more trusted names in polling haven’t been doing heavy polling of the state. Whether this matters is up for debate, as, again, a number of these trusted pollsters weren’t quite able to correctly capture support ahead of November 3.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mRJDcH">
 And with the proper resources — including good modeling, access to voter data, and perhaps a few skilled machine learning engineers — even a less famous polling outfit could arguably approximate the work of more known pollsters. As Shor told Matthews:
 </p>
 <blockquote>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vdofoD">
 Poll Twitter tends to ascribe these mystical powers to these different pollsters. But they’re all doing very similar things. Fundamentally, every “high-quality public pollster” does random digit dialing. They call a bunch of random numbers, roughly 1 percent of people pick up the phone, and then they ask stuff like education, and age, and race, and gender, sometimes household size. And then they weight it up to the census, because the census says how many adults do all of those things.
 </p>
 </blockquote>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kNThBM">
 So the fact that more famous pollsters haven’t done extensive work lately in Georgia may not be a huge factor in the reliability of the results available.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dmeh1G">
 The final factor to keep in mind when looking at Georgia’s polls is that there’s been extensive early voting so far. Some polls — like the one by Targoz Market Research — have attempted to take this into account, separating out early voters and those who plan to vote on Election Day.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yOujUQ">
 On one hand, this might seem to make poll results more accurate: Where there is no early voting, pollsters are looking only at people’s sentiment, essentially how they plan to vote — if they do in fact show up to cast a ballot. But more than 3 million people who voted early in Georgia before early voting ended on December 31. Their support is completely locked in.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BGVDmm">
 However, early voting tends to favor Democrats, especially in the <a href="https://www.vox.com/21527600/early-vote-explained">last election cycle</a>, which saw Democratic leaders advocating for early and mail-in voting as ways to help reduce the spread of the coronavirus. It’s generally assumed that most of the Republicans who plan to vote will do so on Election Day, a reality acknowledged by former Democratic gubernatorial candidate and current voting rights activist Stacey Abrams on ABC’s <a href="https://abcnews.go.com/Politics/week-transcript-21-dr-anthony-fauci-stacey-abrams/story?id=75022446"><em>This Week</em></a> Sunday, “We know Election Day is going to be the likely high turnout day for Republicans, so we need Democrats who haven’t cast their ballot toss turn out.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F8ZHY3">
 Targoz’s data would seem to support this: In the firm’s poll taken December 30 to January 3, among early voters, Ossoff led Perdue 56 percent to 44 percent, while Warnock was ahead of Loeffler 56 percent to 43 percent.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="milTgk">
 This returns to the question of whether pollsters are reaching the right people: If early voters are overrepresented in polling samples, and if they are in fact more likely to be Democrats, this may compound the overinclusion of Democrats Shor identified as the problem with the November 3 polls.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E4yKLx">
 All of this makes it difficult to project who will win either race based on the polls. It seems that both races will be close, and that voters are animated and committed to participating. Any kind of narrow victory would be in the range of a normal polling error, based on the averages. Whether the slight advantages Ossoff and Warnock currently enjoy in the polls will translate into wins — or if they are just mirages created by the challenges inherent to running surveys — will become clear only after the votes are counted.
 </p>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Our predictions for 2021, from the Biden presidency to Covid-19</strong> -
 <figure>
 <img alt="A collage of 2021 predictions." src="https://cdn.vox-cdn.com/thumbor/7baB-HW6e04vJVSUY0Icr6bUutk=/260x0:1820x1170/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68621116/FP_EOY_2021.0.jpg"/>
 <figcaption>
 Zac Freeland/Vox
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 2020 was unpredictable. But Future Perfect is going to predict 2021 anyway.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rDZrWU">
 Some of the most important work journalists and analysts do involves predicting future events. What will happen if President Biden implements a certain anti-poverty policy? How likely is a new study to be borne out in future research? If a new Supreme Court justice is appointed, how will that change how the Court rules on key cases?
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CZ5wB4">
 No one is perfect, and anyone who makes dozens of those predictions every month will be wrong sometimes, but getting these predictions right — and, just as important, being right about your own level of uncertainty — really matters. If policymakers could rely on accurate predictions about the outcome of a foreign war or the advisability of a budget proposal, we could make much better policy decisions.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vECRqe">
 And being good at predictions is a skill like any other — you have to practice it. University of Pennsylvania psychologist Philip Tetlock <a href="https://www.vox.com/2015/8/20/9179657/tetlock-forecasting">studies forecasting</a>, holding tournaments to identify the skills that make people better than their peers at predicting future events. He finds that the most critical skills are thinking numerically, being open to changing your mind, updating your beliefs incrementally and frequently instead of in rare big moments, and — most encouragingly — practicing. The best way to get better at prediction-making is to do it all the time, note your successes, learn from your failures, and refine your understanding of where you’re strongest at making predictions.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kEf5H2">
 So for the third year in a row, the staff of Future Perfect will be providing predictions on the year to come. As with last time, we assign each event a probability between 10 percent and 95 percent (Tetlock found that the best forecasters thought in terms of probabilities rather than simple yes/no predictions). To say that something has an 80 percent chance of happening doesn’t mean it’s definitely happening; it means that if we make five predictions at 80 percent confidence, we’re expecting to have four of them come true. (This kind of probabilistic thinking can trip people up, as <a href="https://fivethirtyeight.com/features/the-media-has-a-probability-problem/">Nate Silver has documented</a>.)
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IlbXOa">
 You can also read our retrospective on our <a href="https://www.vox.com/e/21922847">2020 predictions</a> and on our <a href="https://www.vox.com/future-perfect/2020/1/7/21051910/predictions-trump-brexit-recession-2019-2020">2019 predictions</a>. We don’t speak for Vox, or even for each other, and we hope that where you disagree, you’ll weigh in with predictions of your own. If you want to try your hand, the site <a href="https://www.metaculus.com/questions/3475/future-perfect-2020-series/">Metaculus</a> is a good place; the successor company to Tetlock’s Good Judgment Project also <a href="https://www.gjopen.com/">runs competitions</a>.
 </p>
 <h3 id="6fRpNm">
 The United States
 </h3>
 <figure class="e-image">
 <pre><code>    &lt;img alt=" " src="https://cdn.vox-cdn.com/thumbor/SNON1HaRBPv9aWIIfU97-Wkyb28=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22191469/FP_EOY_Biden_copy.jpg" /&gt;
  &lt;cite&gt;Zac Freeland/Vox&lt;/cite&gt;</code></pre>
 </figure>
 <h4 id="vAiOS8">
 Trump will uneventfully leave office on January 20 (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4U0nqo">
 To be clear, there is at this point no doubt about whether Trump will leave office on January 20, the official inauguration date for the new president, Joe Biden. Biden secured more electoral votes. Trump’s campaign made a lot of noise but didn’t bring serious allegations of fraud to court, and no court would grant his proposed remedy of overturning the election. His backers have held alternate Electoral College votes and threatened the real electors, but that won’t change the outcome either.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cslBPF">
 There is likely to be some drama and potentially even violent street protests on January 6, when the Electoral College vote is read before Congress, but that, too, is nearly certain to be political theater that can’t overturn the legal election results.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K4xO0V">
 The only part of this up in the air is the key word “uneventfully.” In December claims circulated that Trump has told his advisers he <a href="https://nymag.com/intelligencer/2020/12/will-trump-leave-white-house-january-20-inauguration.html">won’t leave</a>. If the president has to be dragged by force out of the White House, or stages a protest to Biden’s inauguration on Inauguration Day, then I’ll be proven wrong. But my guess is that once every remedy has been exhausted, the president will retreat to Mar-a-Lago or a similar location, continuing to tweet that the election was unfair. <em>—Kelsey Piper</em>
 </p>
 <h4 id="nb4umx">
 Biden will have a treasury secretary, secretary of state, defense secretary, and attorney general confirmed by the end of the year (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0Wq7fU">
 One of the more depressing political predictions I’ve seen floating around is that, should Republicans hold on to at least one of the <a href="https://www.vox.com/2021/1/4/22204765/stakes-georgia-senate-runoff-elections-stakes">two Georgia Senate seats</a>, they will block Biden from assembling a Cabinet, and we’ll have four years of unprecedented political gridlock.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2i6tLT">
 My general starting point for predicting politics is to predict that things will be bad, but not as bad as the gloomiest predictions circulating among pundits, and often mostly bad along dimensions they’re not tracking. Making it impossible for Biden to appoint a secretary of state or similar would be high-profile and divisive; I expect most gridlock to be introduced through less clear-cut strategies. Plus, there’s a chance that Democrats win both Georgia runoffs, which look like toss-ups in the polls.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zpAbyS">
 Given all that, why only 70 percent? One lesson I’ve learned from doing these predictions is that the more detail they have, the more can go wrong. I would bet very confidently that Biden will have a secretary of state, or that he’ll have a defense secretary, etc. But this prediction specifies he’ll have all four, so I should be correspondingly less confident in it. —<em>KP</em>
 </p>
 <figure class="e-image">
 <pre><code>    &lt;img alt=" " src="https://cdn.vox-cdn.com/thumbor/ejRIsEh3ljVhUDg2f9WyusY_9LE=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22191475/FP_EOY_SCOTUS.jpg" /&gt;
  &lt;cite&gt;Zac Freeland/Vox&lt;/cite&gt;</code></pre>
 </figure>
 <h4 id="3iwgmD">
 At least one US state will have an abortion ban currently blocked by the courts go into effect (40 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Oy1AeQ">
 The Supreme Court, now dominated by justices who think <em>Roe v. Wade</em> was wrongly decided, might overturn it in the next year. More likely, they might technically leave it in place but hollow it out. I consider it pretty likely that they’ll aim to reduce abortion access only a little, and that they won’t overturn <em>Roe</em> or take any larger steps to allow states to pass sweeping abortion bans.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LmP0wN">
 That said, there’s a significant chance this year will see sweeping changes in abortion access in America. Some <a href="https://www.guttmacher.org/state-policy/explore/abortion-policy-absence-roe">10 states have so-called trigger laws</a> on the books to immediately ban all or almost all abortions if <em>Roe</em> is overturned, and nine other states have laws on the books that are currently blocked under <em>Roe</em>. In <a href="https://apps.legislature.ky.gov/record/19rs/hb148.html">Kentucky</a>, for example, one such law would make it illegal to get an<strong> </strong>abortion past six weeks, even in cases of rape and child molestation, even if the fetus is not viable and will regardless not survive, and even if the pregnant person’s health would be substantially harmed, if they’re not at risk of death or permanent organ damage.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PB7Mkm">
 In the long run, I expect very few US states to stand by such total bans — they’re overwhelmingly unpopular with the American public, most of whom <a href="https://www.npr.org/2019/06/07/730183531/poll-majority-want-to-keep-abortion-legal-but-they-also-want-restrictions">want abortion available at least under limited circumstances</a>, especially early in a pregnancy. But they’ve made their way onto the books, protected from public scrutiny by the fact that they’re currently unconstitutional, and if the Supreme Court lets them go into effect, millions of Americans will temporarily live under deeply unpopular, extreme anti-abortion laws.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OovRaO">
 I consider this somewhat unlikely — the Supreme Court tends to prefer not to take such strong steps when it can instead advance its aims more gradually by chipping away, rather than overturning, <em>Roe</em> — but still likely enough that it ought to be on everyone’s radar. <em>—KP</em>
 </p>
 <h4 id="UUystJ">
 No one in Trump’s immediate family will be indicted (65 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7mmqng">
 Let me be very clear: I am not saying that Jared Kushner and Donald, Melania, Donald Jr., Ivanka, Eric, and the oft-forgot Tiffany Trump are innocent of any and all crimes. I’ve read a little bit on those folks and <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fwww.newyorker.com%2Fnews%2Fnews-desk%2Fhow-ivanka-trump-and-donald-trump-jr-avoided-a-criminal-indictment&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2Ffuture-perfect%2F22167877%2Fpredicting-biden-coronavirus-transition-vaccines-2021" rel="sponsored nofollow noopener" target="_blank">they seem a bit shady</a>, to be honest.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S47LHi">
 What I am saying is that liberals right now are overestimating the enthusiasm that will remain for state-level investigations into the Trump family once Trump is out of office. Interest in Bush-era abuses vanished almost immediately in 2009. New York Attorney General Letitia James and Manhattan District Attorney Cy Vance are political actors and will notice that the voter demand for such investigations no longer exists come mid-2021. And the Biden Justice Department will likely be reticent to prosecute his predecessor, not least if Hunter Biden is still the target of legal scrutiny. —<em>Dylan Matthews</em>
 </p>
 <h4 id="K53FYk">
 Trump approval rating by year’s end will be in the 40 to 45 percent range (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DaTxtC">
 The president’s approval ratings have been flat throughout his term; no matter what he does, about 55 to 60 percent of the country dislikes him and <a href="https://www.vox.com/2020/9/2/21409364/trump-approval-rating-2020-election-voters-coronavirus-convention-polls">40 to 45 percent of the country likes him</a>.<strong> </strong>An economic boom didn’t change that. A pandemic and attendant economic crash didn’t, either. His refusal to concede the election hasn’t done it. Will that change when he’s out of office?
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f5OEL2">
 My bet is on “no.” Most presidents experience a bump in popularity — from nostalgia — once<strong> </strong>they’re out of office, but it doesn’t seem likely to me that Trump will see such a bump, for the same reason that no other events have affected his approval ratings. Americans know how they feel about Trump, and at this point those feelings are barely responsive to anything Trump does. <em>—KP</em>
 </p>
 <h4 id="CIEKtK">
 The US unemployment rate will stay above 5 percent through November (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DdZKCA">
 The Trump White House used to talk, back in the spring, about a <a href="https://www.marketwatch.com/story/feds-kashkari-throws-cold-water-on-white-house-optimism-about-a-snapback-economic-recovery-2020-05-10">“snapback” recovery</a>: You lift social distancing restrictions, stuff goes back to normal, and the economy becomes what it was in January 2020, with unemployment at 3.6 percent and falling. I don’t see it happening.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wJV1Bf">
 Yes, the vaccine rollout will spur people to spend more again. But the rollout will also be gradual, and there will be tremendous uncertainty about what it’s safe for vaccinated people to do, when to stop wearing masks, when it’s okay to go on airplanes or to indoor restaurants, and so forth. All that will weaken a vaccine-driven recovery.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Hk55G4">
 What’s more, <a href="https://www.vox.com/2020/12/20/22191834/congress-coronavirus-stimulus">Congress chose in December</a> to pass real but inadequate stimulus measures. The $300/week bonus to unemployment insurance is good but not enough, and giving almost no aid to states and localities is ridiculous. The inadequate assistance, and lack of retroactive aid for August through December when emergency UI had expired, means there’ll be some <a href="https://www.brookings.edu/wp-content/uploads/2016/06/2012a_Dynan.pdf">debt overhang</a> from people using credit cards and other kinds of loans to get by without congressional assistance. The low level of state and local aid also means <a href="https://www.vox.com/policy-and-politics/2020/4/22/21228229/coronavirus-bailout-money-state-austerity-budget-shortfall">hiring and purchases by state and local governments will be low</a>, which will meaningfully hurt the recovery.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="prEtXI">
 The <a href="https://www.vox.com/future-perfect/22163440/joe-biden-fed-board-governors-build-back-better">Fed</a> can, and should, ramp up asset buys (“quantitative easing”) and keep promising to keep interest rates low to aid the recovery, but the economy needs more drastic demand stimulus than that. With a closely divided Senate, <a href="https://www.vox.com/2021/1/4/22204765/stakes-georgia-senate-runoff-elections-stakes">possibly under Republican control</a>, I don’t think that additional fiscal stimulus will be forthcoming after the December deal. The result will be a longer and more painful recovery than was necessary. —<em>DM</em>
 </p>
 <h4 id="VloDOG">
 US poverty will be higher in late 2021 than it was in late 2020 (80 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lSOUY8">
 I’ve written a lot about the rise in poverty this year since enhanced unemployment insurance (the $600 per week top-up included in the initial Covid-19 relief bill) expired at the end of July, and the <a href="https://www.vox.com/future-perfect/21582005/joe-biden-poverty-covid">projections that it will be rising more still by January</a>. The basics are simple: The US is in a recession, the extremely generous stimulus policies of April through July were so extensive as to actually reduce<em> </em>poverty despite that recession, but since the federal government stopped helping things got progressively worse.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="687DKQ">
 The <a href="https://www.vox.com/2020/12/20/22191834/congress-coronavirus-stimulus">end-of-2020 deal in Congress</a> included a more modest, $300/week UI benefit boost and some modest direct cash payments to households, which should help reduce poverty temporarily. But I fear that the deal, which <a href="https://www.politico.com/news/2020/12/16/congress-deal-covid-relief-446244">looks to expire at the end of March</a>, will result in a similar dynamic as the 2020 stimulus: a brief improvement, followed by deterioration upon its expiration, and gridlock in Congress that prevents further progress.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rSOBUS">
 To be specific, for this prediction I’ll be relying on two monthly measures of poverty: one from the <a href="https://www.povertycenter.columbia.edu/news-internal/2020/covid-projecting-monthly-poverty">Center on Poverty and Social Policy</a> at Columbia, and <a href="http://povertymeasurement.org/covid-19-poverty-dashboard/">one by economists Bruce Meyer, James X. Sullivan, and Jeehoon Han</a>. <em>—DM</em>
 </p>
 <h4 id="hNextx">
 The median home price in the Bay Area will fall 5 percent or more (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tjhdP5">
 For years, people have been declaring that the Bay Area — my home — is doomed, even as its housing prices and job market continued to boom. But 2020 may have really changed things. Many companies have moved out of expensive San Francisco. Many of their employees have, too. Most people agree that remote work isn’t quite as good — but it provides enormous advantages compared to having to hire in the most expensive market in the United States. I wouldn’t bet on a massive outflow from the Bay in the next year, but I think there will be a steady one, enough to continue this year’s depression in home prices and rents.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hJDrqY">
 To be clear, I think this is a tragedy. With good governance, the San Francisco area could’ve risen to the moment and become a global city with affordable housing for both locals and new arrivals, demonstrating that its values create good places for people to live their lives. Instead, it demonstrated the opposite. It took Covid-19 to bring these consequences, but they were eventually going to happen. <em>—KP</em>
 </p>
 <h4 id="QROzdj">
 100 million Americans will be vaccinated, at least partially, against the coronavirus by end of April (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gtf4Xw">
 Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, has predicted that the vaccine will be widely available to Americans <a href="https://www.cnbc.com/2020/12/16/dr-fauci-says-us-could-return-to-normal-by-mid-fall-if-most-people-get-covid-vaccine.html">by April</a>. Some back-of-the-envelope math tells me there’ll be enough supply to fully vaccinate 100 million people.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LiWSmw">
 Pfizer has agreed to give the US 100 million doses by the end of March; since each person has to get two doses, that’s enough to fully vaccinate 50 million. And <a href="https://www.reuters.com/article/us-health-coronavirus-moderna/moderna-to-supply-up-to-125-million-covid-19-vaccine-doses-globally-in-first-quarter-idUSKBN28D3FA">Moderna</a> says it’ll have 85 million to 100 million doses ready for Americans in the first quarter, providing full inoculation for perhaps another 50 million. Some other vaccines, such as AstraZeneca’s, may also start rolling in.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wnc5y8">
 That said, it’s not enough for the US to have lots of vaccine doses on hand; it also has to distribute the doses efficiently. Distribution has been frustratingly slow in December and the early days of January, placing the country far <a href="https://www.bloomberg.com/news/articles/2020-12-29/u-s-vaccinations-at-200-000-a-day-run-far-short-of-warp-speed">behind</a> its initial target. So I’m not highly confident that the US will manage to get two shots each to 100 million people by end of April.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ALQYqA">
 However, I do think there’s a significant likelihood of getting at least one shot to that many people within that timeframe. <a href="https://www.businessinsider.com/fauci-us-vaccine-rollout-timeline-million-people-per-day-2021-1">Fauci says</a> vaccination rates may accelerate soon, and he thinks the country can hit a target of 1 million shots per day. That rate would make <a href="https://www.cnn.com/2020/12/08/politics/biden-100-million-vaccines-100-days/index.html">Biden’s stated goal</a> — distributing 100 million shots in his first 100 days as president — achievable. <em>—SS</em>
 </p>
 <h4 id="lFqI2w">
 Restaurant reservations and consumer spending outside the home back to normal by the end of year (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dBtdMv">
 With the vaccine for the novel coronavirus widely available by next summer, I predict that the lockdown will extend longer than we’d like but certainly not through the next year. I expect that by the fall, consumer spending will be back to normal — plausibly even boosted by pent-up demand. I’ll look at <a href="https://www.bea.gov/recovery/estimates-from-payment-card-transactions">this page of government statistics</a> to see if I got this one right. <em>—KP</em>
 </p>
 <h3 id="sAHgrf">
 The world
 </h3>
 <h4 id="o7PIRW">
 A deadly new zoonotic outbreak will emerge (55 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DDc2Hq">
 I know, I know, everyone is going to hate me for saying this. And to be clear, I’m not saying we’ll see an outbreak that rises to the level of a pandemic like Covid-19, which reached into pretty much every corner of the planet. But I do think we may see the emergence of a disease that starts in animals, spills over into humans, and causes at least a few dozen deaths.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ti6BBx">
 Why do I think this? As Martha Nelson, who studies viruses at the National Institutes of Health, <a href="https://www.vox.com/2020/10/21/21363990/factory-farms-next-swine-influenza-pandemic">told us</a> on the <em>Future Perfect</em> podcast, we’re “playing Russian roulette” with animals. Our <a href="https://www.vox.com/future-perfect/2020/3/31/21199917/coronavirus-covid-19-animals-pandemic-environment-climate-biodiversity">environmental practices</a> (like cutting down forests and destroying other animal habitats) and our <a href="https://www.vox.com/future-perfect/2020/4/22/21228158/coronavirus-pandemic-risk-factory-farming-meat">factory farming system</a> (where pigs, chickens, cows, and more are crowded together in unsanitary conditions) make zoonotic outbreaks increasingly likely.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I5pd7J">
 No less than 75 percent of new diseases originate in animals, and they’ve been popping up with alarming frequency in recent years. H5N1 came from birds in 1997. H1N1 came from pigs in 2009. Ebola spread from bats in 2014. There’s also Zika, and West Nile, and several others. I’m afraid we’ll see a new killer zoonotic disease in 2021. I hope I’m wrong. <em>—SS</em>
 </p>
 <h4 id="QDUwuz">
 The US will enact policies to hold China accountable for its treatment of Muslims, but the internment camps will remain open (80 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JpK9Gv">
 In 2020, the Biden campaign referred to China’s repression of Uighur Muslims as <a href="https://www.axios.com/biden-campaign-china-uighur-genocide-3ad857a7-abfe-4b16-813d-7f074a8a04ba.html">“genocide.”</a> In 2021, I have no doubt that Biden will repeatedly condemn the camps where more than 1 million of them have been held. I am also fairly<strong> </strong>confident that the US will pass at least one significant bill aimed at holding China accountable, especially given that Uighur forced labor has <a href="https://www.aspi.org.au/report/uyghurs-sale">leached into the supply chain</a> of American companies.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rmH7Ly">
 But I see no reason to think that China will shut down the camps in 2021. The government there has already proven that targeted sanctions do not have swaying power; although <a href="https://www.nytimes.com/2020/07/09/world/asia/trump-china-sanctions-uighurs.html">the US imposed sanctions on officials</a> like Xinjiang’s Communist Party Secretary Chen Quanguo, the camp system persists.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gVB8ra">
 Getting China to shut down the system would require much bigger incentives — financial as well as reputational. But China is simply so economically powerful that it’s hard to imagine the US being willing to hit it too hard financially. And the world is struggling to even get the reputational piece of the puzzle in place; the International Criminal Court recently <a href="https://www.nytimes.com/2020/12/15/world/asia/icc-china-uighur-muslim.html">decided not to investigate</a> China’s repression of the Uighurs. <em>—SS</em>
 </p>
 <h4 id="smgSmE">
 The Hadi government and Houthi rebels in Yemen reach a peace agreement (60 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Bjx9JF">
 This bet is motivated by a few developments that together make me think 2021 could be the year <a href="https://www.vox.com/2019/1/30/18203857/yemen-war-deaths-injured-chart-intelligence">the devastating conflict</a> in Yemen that has <a href="https://acleddata.com/2020/03/25/acled-resources-war-in-yemen/">already killed more than 100,000 people</a> comes to an end — or, at the very least, the year that a temporary ceasefire begins as peace talks get underway. My specific prediction is that there will be either a formal peace deal between the Saudi-backed Hadi government and the Iranian-backed Houthis or else a tentative ceasefire. The latter sadly seems more likely.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d9wn4w">
 The biggest development is Joe Biden’s election. The US is not the main actor in the civil war, but it is an important actor for the support it has given Saudi Arabia (including <a href="https://www.nytimes.com/2018/05/03/us/politics/green-berets-saudi-yemen-border-houthi.html">actual special forces troops on the ground</a>). <a href="https://www.vox.com/2019/9/10/20849004/trump-yemen-war-saudi-arabia-mbs-ndaa">Bipartisan pressure from Congress</a> to end support for the Saudi air war has been mounting throughout Trump’s term, and a president less close to Saudi de facto leader Mohammed bin Salman seems likelier to yield to that pressure.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BFfA9v">
 The Biden campaign in fact <a href="https://www.justsecurity.org/73798/biden-must-stick-to-his-pledge-to-end-us-support-for-the-yemen-war/">promised to end support for the Saudis</a> in Yemen, and incoming senior administration officials — Secretary of State-designate Antony Blinken, Director of National Intelligence-designate Avril Haines, National Security Adviser-designate Jake Sullivan, and UN Ambassador-designate Linda Thomas-Greenfield — <a href="https://twitter.com/SPMiles42/status/1330741626734604289">signed an open letter</a> urging the same.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mw0Y48">
 At the same time, Biden and his team are eager to <a href="https://www.washingtonpost.com/politics/2020/12/09/biden-foreign-policy-iran/">have the US rejoin the multilateral nuclear deal with Iran</a> and to more broadly reverse the Trump administration’s efforts to antagonize the country and reverse all diplomatic progress made under Obama. Iran is understandably hesitant to just let the US ping-pong in and out of agreements from election to election, and so withdrawing from Yemen and working to broker a peace between Iran’s proxies and Saudi Arabia’s would be an important show of good faith on the US’s part.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TVaIS3">
 Beyond Biden, though, there have been encouraging signs on the ground in Yemen. Saudi Arabia <a href="https://www.reuters.com/article/yemen-security-saudi-usa-int/saudis-seek-buffer-zone-with-yemen-in-return-for-ceasefire-sources-idUSKBN27X20B">recently signaled openness to a ceasefire</a> (albeit on terms the Houthis may not accept), and unilaterally <a href="https://www.reuters.com/article/us-yemen-security-saudi/saudi-led-coalition-announces-ceasefire-in-five-year-yemen-war-idUSKCN21Q2WR">called a brief ceasefire in April</a>. There was a <a href="https://www.reuters.com/article/uk-yemen-security-prisoners-un/yemens-warring-parties-agree-to-their-largest-prisoner-swap-as-u-n-seeks-ceasefire-idUSKBN26I064">large-scale prisoner swap in September</a>. On their own, these are not grounds for unbridled optimism, but they suggest that an engaged and motivated US administration, newly distanced from Saudi Arabia, could help force a truce. <em>—DM</em>
 </p>
 <h4 id="tLrjse">
 LDP continues to govern Japan (90 percent), CDU continues to govern Germany (80 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fqoMPz">
 I’m grouping these together on the somewhat tenuous grounds that I’m predicting each major former<strong> </strong>Axis power will continue to be governed by the center-right party that has dominated its politics since shortly after World War II (this pattern has not held in Italy because nothing about Italian politics makes any sense).
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7TOaTw">
 The Liberal Democratic Party’s grip on Japan and the Christian Democratic Union’s grip on Germany are not absolute. Japan has had brief periods of non-LDP rule, such as when the opposition Democratic Party held office from 2009 to 2012, but they have tended to be short-lived, and the opposition to the LDP is prone to factionalism and infighting. <a href="https://en.wikipedia.org/wiki/Opinion_polling_for_the_next_Japanese_general_election">Polling</a> suggests the party and new Prime Minister Suga Yoshihide don’t face any serious opposition in 2021. It doesn’t hurt that the country has weathered Covid-19 exceptionally well.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JZUkHS">
 Similarly, the German Social Democratic Party (SDP) has been able to form cabinets: Willy Brandt and Helmut Schmidt’s governments in West Germany from 1969 to 1982, and Gerhard Schroeder’s from 1998 to 2005. But in the 15-year regime of Angela Merkel, the SDP has usually been the junior coalition partner to the Christian Democrats and is in danger of losing its status as the dominant center-left party in the country to the Greens. As it stands, though, the Greens are a <a href="https://en.wikipedia.org/wiki/Opinion_polling_for_the_2021_German_federal_election">distant second to CDU by some 15 to 20 points</a>. The real question is who, exactly, a CDU win would make prime minister, as Merkel is retiring after the election and the <a href="https://en.wikipedia.org/wiki/2021_Christian_Democratic_Union_of_Germany_leadership_election">CDU leadership race continues</a>. —<em>DM </em>
 </p>
 <figure class="e-image">
 <pre><code>    &lt;img alt=" " src="https://cdn.vox-cdn.com/thumbor/Znw8aG0nfELvfXKdn5T7CijKW9E=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22191524/FP_EOY_India.jpg" /&gt;
  &lt;cite&gt;Zac Freeland/Vox&lt;/cite&gt;</code></pre>
 </figure>
 <h4 id="Txsjen">
 India’s economy will grow in quarters 1-3 of 2021 after shrinking briefly in 2020 (70 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8jVOVT">
 One of the greatest tragedies of the Covid-19 crisis is that it forced low-income countries to choose between halting years and years of progress against poverty, and allowing a massive public health catastrophe to unfold. India opted for mandatory activity restrictions in certain areas perceived as at risk of Covid-19 outbreaks in the spring, and the predictable result of that and the global economic contraction was a <a href="https://www.cnn.com/2020/11/27/economy/india-recession/index.html">recession</a>, the <a href="https://www.livemint.com/news/india/india-s-tryst-with-recession-40-years-ago-11598862207397.html">first since 1980</a>. India reversed course and reopened quite quickly, and is now up to over <a href="https://www.nytimes.com/interactive/2020/world/asia/india-coronavirus-cases.html">10 million cases</a> (second only to, well, the US).
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9ZdoAP">
 If the public health situation deteriorates further and necessitates more lockdowns, the recession could drag out. But as it stands, the situation seems to be improving. <a href="https://www.cnn.com/2020/11/27/economy/india-recession/index.html">From July to September</a>, the economy shrank by 7.5 percent year over year compared to a shocking <a href="https://pib.gov.in/PressReleasePage.aspx?PRID=1650021">24 percent contraction</a> in April through June. That gives me hope that in the new year, the economy will be growing again.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3WbtJR">
 India releases its GDP numbers in a fiscal year schedule where April through June was “quarter 1” of the “2020-2021 fiscal year,” so to be specific, what I’m predicting is that India’s GDP will grow in both nominal and real terms in quarter 4 of the 2020-2021 fiscal year, and quarters 1 and 2 of the 2021-2022 fiscal year. <em>—DM </em>
 </p>
 <h4 id="Wz9M9H">
 At least three new basic income pilots will be launched (75 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qVjH53">
 Covid-19 <a href="https://psyarxiv.com/csr3u/">boosted public support</a> for the idea of a basic income. As the pandemic unexpectedly wiped out millions of people’s finances through no fault of their own, advocates argued that citizens desperately need some sort of guaranteed payment to fall back on. Some governments and philanthropists listened. <a href="https://www.vox.com/future-perfect/2020/2/19/21112570/universal-basic-income-ubi-map">Spain</a> started offering payments of up to 1,015 euros ($1,145) to the poorest families in the country. <a href="https://www.vox.com/future-perfect/2020/8/25/21399408/germany-basic-income-ubi-covid-19-pandemic">Germany</a> started a new basic income experiment. And in the US, a coalition of mayors — with a $15 million grant from Twitter CEO Jack Dorsey — launched guaranteed income pilots in several US cities.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dYGm9g">
 I think basic income will continue to gain momentum in 2021, with at least three new pilots launching globally. I’m not expecting to see much action at the national level — with <a href="https://www.vox.com/future-perfect/2020/2/19/21112570/universal-basic-income-ubi-map">a few exceptions</a>, basic income programs offer money to small groups of a few hundred or few thousand people, not a whole country — but I think we’ll see a good amount of action at the city level. That’s because the global economy won’t recover overnight; the need precipitated by the pandemic will persist well into the year, and the illusion that only lazy people ever need “free money” has been shattered. <em>—SS </em>
 </p>
 <h4 id="7Flsxc">
 No more countries will leave the EU (80 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QIFWso">
 After Brexit (remember when Brexit was the biggest story in the world?), there was widespread speculation that Britain’s departure foretold the end of the EU. That hasn’t been borne out, and I don’t expect this next year to change that. Why not? First, Britain’s departure from the EU has embarrassed its two major political parties, damaged its economy, and infuriated its citizens — not exactly an inspiring model. Second, Britain was unusual anyway: Most countries in the EU plainly gain a lot from being there, and have more of a cultural identity as part of Europe. And there are no mainstream political movements for withdrawal. <em>—KP</em>
 </p>
 <h3 id="o5ilT5">
 Technology and environment
 </h3>
 <h4 id="69gdhG">
 An AI breakthrough will lead to a game-changing advance in biology (75 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iNr0cq">
 In 2020, a couple of amazing AI breakthroughs rocked the biology world. First, researchers trained a neural network to predict which molecules (out of 107 million possibilities!) would have antibacterial properties, enabling them to <a href="https://www.vox.com/future-perfect/2020/2/27/21153521/ai-antibiotic-drug-resistance-superbugs">identify brand new types of antibiotics</a>. Then, DeepMind’s AlphaFold system <a href="https://www.vox.com/future-perfect/22045713/ai-artificial-intelligence-deepmind-protein-folding">cracked the “protein folding problem,”</a> a grand challenge of biology that<strong> </strong>had vexed scientists for 50 years. That’ll likely speed up and improve scientists’ ability to develop new drugs.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JBupfs">
 The AI field is moving at such a fast clip that I think we’ll see at least one breakthrough of this magnitude in 2021. I’m talking about something that pushes biology forward by a significant margin. <em>—SS</em>
 </p>
 <h4 id="9N4g0U">
 Global carbon emissions will increase (90 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Wjli4X">
 This is a perennial prediction, one of those that is mostly true every year. Global carbon emissions keep rising because the world economy is growing faster than it’s shifting to non-greenhouse-gas-emitting energy sources. Last year, <a href="https://www.vox.com/e/21922847">global carbon emissions fell</a>, but that was caused by the near-total shutdown of the global economy, which won’t be sustained in 2021. In fact, I’m even more confident than usual that we’ll see carbon emissions grow, because they will increase from 2020’s lower baseline. <em>—KP</em>
 </p>
 <h4 id="dAfiUB">
 Average world temperatures will increase relative to 2020 (80 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="C7q7c3">
 Average world temperatures have increased most years for the past several decades, though there’s a little bit of noise, so any given year isn’t a sure thing. This is a direct consequence of increased carbon emissions, but with some lag — I don’t expect last year’s small decrease in CO2 to produce a decline in average global temperatures, but just a slightly slower rate of increase. <em>—KP</em>
 </p>
 <h4 id="OgyTJZ">
 Plant-based meat market share will increase by at least 20 percent (80 percent)
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ucpber">
 In the past few years, we’ve seen the takeoff of <a href="https://www.vox.com/2019/5/28/18626859/meatless-meat-explained-vegan-impossible-burger">plant-based meat products</a> — foods designed to have the taste and nutrient content of meat without the environmental, health, and animal welfare costs of factory farming. Plant-based meat is only a tiny fraction of overall animal meat sales, but it’s grown dramatically in the past few years.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vxjzNU">
 Even if that growth slows, it should comfortably top 20 percent from the previous year. The return of restaurant dining is likely to help the plant-based meat market, too — while the products are available in supermarkets and have done well there, they got their start in restaurants, where it’s easier to convince consumers to try something new and unfamiliar. I’ll measure this by getting data on sales of refrigerated plant-based meat products from the Good Food Institute — meaning this prediction, if it’s close, might not be settled until the following March, when all its data for the year is in (unless preliminary data can tell us enough).<strong> </strong><em>—KP</em>
 </p>
 <h4 id="dviMbl">
 </h4>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump’s last rally as president was supposed to be about the Georgia runoffs. It wasn’t.</strong> -
 <figure>
 <img alt="US-POLITICS-VOTE-SENATE" src="https://cdn.vox-cdn.com/thumbor/55rcG4FL2JyEbtfGEcTwW6oCuIM=/435x0:4687x3189/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68620503/1230427962.0.jpg"/>
 <figcaption>
 Trump arrives at his rally in Dalton, Georgia, on Monday. | Mandel Ngan/AFP via Getty Images
 </figcaption>
 </figure></li>
 </ul>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Surprise! It ended up being about himself.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CBHF9B">
 President Donald Trump’s trip to Dalton, Georgia on Monday evening was ostensibly about stumping for Republican Sens. David Perdue and Kelly Loeffler ahead of their <a href="https://www.vox.com/2021/1/4/22204765/stakes-georgia-senate-runoff-elections-stakes">hard-fought runoff elections</a> on Tuesday. Predictably, however, Trump spent much of what’s likely to be his last rally as president whining about his loss to President-elect Joe Biden and pushing unfounded conspiracy theories about the election being stolen from him.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hIdX9R">
 In fact, the very first words out of Trump’s mouth after “Hello, Georgia,” were: “By the way — there’s no way we lost Georgia. There’s no way. That was a rigged election.”
 </p>
 <div id="ec8C4e">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 "Hello, Georgia. By the way -- there's no way we lost Georgia. There's no way. That was a rigged election." -- the first words out of Trump's mouth in Dalton, Georgia <a href="https://t.co/JBlBDFKloU">pic.twitter.com/JBlBDFKloU</a>
 </p>
 — Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1346278421802987520?ref_src=twsrc%5Etfw">January 5, 2021</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8VammD">
 During the early part of his speech, Trump went through the motions of trying to promote Perdue and Loeffler, but his heart didn’t really seem in it. Trump <a href="https://twitter.com/atrupar/status/1346278880726888448">didn’t seem to realize that Perdue wasn’t actually in attendance</a> (he’s quarantining after a Covid-19 exposure) and instead of mustering much enthusiasm for the senators, Trump’s followers spent much of the rally chanting things <a href="https://twitter.com/atrupar/status/1346287676778012678">like “fight for Trump!” and “stop the steal!”</a>
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="n5Pdj7">
 As you’d expect, Trump spent a good bit of time rubbing his own sores. He criticized the Supreme Court for “not stepping up” for him and, along similar lines, blasted Georgia’s Republican governor and secretary of state — Brian Kemp and Brad Raffensperger, respectively — <a href="https://www.vox.com/2021/1/4/22211984/trump-raffensperger-georgia-hawley-cruz-election">for not helping him steal the election</a>.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r5CXs9">
 “I’ll be here in about a year and a half campaigning against your governor, I guarantee you,” Trump said about Kemp.
 </p>
 <div id="pM3VhS">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 "I'll be here in about a year and a half campaigning against your governor, I guarantee you" -- Trump has now pivoted to bashing Georgia's Republican governor and secretary of state <a href="https://t.co/KKP2v7z8bw">pic.twitter.com/KKP2v7z8bw</a>
 </p>
 — Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1346281375817752582?ref_src=twsrc%5Etfw">January 5, 2021</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dJMcSp">
 The speech came a day after <a href="https://www.washingtonpost.com/politics/trump-raffensperger-call-georgia-vote/2021/01/03/d45acb92-4dc4-11eb-bda4-615aaefd0555_story.html?utm_medium=social&amp;utm_source=twitter&amp;utm_campaign=wp_main">the Washington Post published bombshell audio</a> of a phone call from over the weekend in which Trump unsuccessfully tried to bully Raffensperger into helping him “find” enough votes in the state to overcome his loss to Biden. The call was widely criticized and as my colleague Ian Millhiser <a href="https://www.vox.com/2021/1/4/22213031/trump-georgia-crime-criminal-brad-raffensperger-election-call-fraud-felony">wrote</a> was “most likely a criminal offense,” but Trump — stealing a page from his impeachment playbook — tried to turn reality on its head by proclaiming, “everyone loved my phone call.”
 </p>
 <div id="lbfKYf">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 "Everyone loved my phone call" -- Trump on his widely criticized phone call with the Georgia secretary of state in which he tried to bully him into helping him steal the election <a href="https://t.co/ZpCoSIi1KO">pic.twitter.com/ZpCoSIi1KO</a>
 </p>
 — Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1346295710208172033?ref_src=twsrc%5Etfw">January 5, 2021</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1JI2vL">
 Other greatest hits that Trump revisited on Monday including <a href="https://twitter.com/atrupar/status/1346292089206812673">basking in “lock her up!” chants</a> directed at Hillary Clinton, bashing the media — <a href="https://twitter.com/atrupar/status/1346290560416493571">including Fox News</a>, and winking and nodding <a href="https://twitter.com/atrupar/status/1346288063497064454">toward the deranged QAnon conspiracy theory</a>.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ioyKuS">
 Notably, the coronavirus pandemic was never mentioned at a rally in which many attendees were packed together and mostly not wearing masks.
 </p>
 <h3 id="Xtb5yc">
 It’s Trump’s Republican Party now
 </h3>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ocSDko">
 Loeffler seemed to understand the importance of putting Trump first. When she took to the stage for brief remarks, she immediately announced that she’s joining a <a href="https://www.vox.com/2021/1/4/22213246/republican-senators-hawley-cruz-cotton-trump-electoral-college-presidential-election-joe-biden">group of Republican senators</a> who during a congressional proceeding on Wednesday plan to challenge Biden’s Electoral College win, saying, “I have an announcement, Georgia. On January 6, I will object to the Electoral College vote. That’s right. We’re gonna get this done!”
 </p>
 <div id="5cqqO1">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 "I'll be here in about a year and a half campaigning against your governor, I guarantee you" -- Trump has now pivoted to bashing Georgia's Republican governor and secretary of state <a href="https://t.co/KKP2v7z8bw">pic.twitter.com/KKP2v7z8bw</a>
 </p>
 — Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1346281375817752582?ref_src=twsrc%5Etfw">January 5, 2021</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tWhM2W">
 But statements of that sort weren’t enough to close the audience’s obvious enthusiasm gap. On numerous occasions cameras panned across obviously bored and silent faces as Trump offered praise for Loeffler and Perdue that didn’t go much beyond their support for him.
 </p>
 <div id="lXkeYU">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 Take a gander at how bored Trump's followers look as he tries to pump up David Perdue <a href="https://t.co/SVIItgzkZs">pic.twitter.com/SVIItgzkZs</a>
 </p>
 — Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1346285131598880770?ref_src=twsrc%5Etfw">January 5, 2021</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m1f4Ot">
 Throughout the rally, Trump tried to keep hope alive that he still might serve another term in office. He suggested <a href="https://www.vox.com/2021/1/4/22213246/republican-senators-hawley-cruz-cotton-trump-electoral-college-presidential-election-joe-biden">congressional proceedings on Wednesday</a> in which his Electoral College loss to Biden will be certified might produce a drastic reversal of fortunes, even while it’s quite clear — given the fact most lawmakers plan to vote to certify the vote — it won’t.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zcjo24">
 At one point the president <a href="https://twitter.com/atrupar/status/1346279952602324992">said</a>, “I hope Mike Pence comes through for us” — suggesting the vice president, who will oversee Wednesday’s hearing, might attempt to overturn the results in the eleventh hour — and at others he openly pressured Sen. Mike Lee (R-UT) to join a group of Republican senators who have announced they plan to challenge the electoral results.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pAqYJF">
 “MIke Lee is here, too. But I’m a little angry at him today,” Trump <a href="https://twitter.com/atrupar/status/1346288506281328640">said</a>, alluding to Lee’s refusal (so far) to join the Republican effort to challenge the results.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GlbGKq">
 But at other points, Trump spoke about his presidency in the past tense, lamenting (falsely) that Mexico “is paying” for his border wall — but then adding, “or if I were here, they would be.”
 </p>
 <div id="idrQwD">
 <blockquote class="twitter-tweet">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
 "The wall. The wall. The wall. Remember? 'We'll build a wall. We're gonna build a wall.' And that's right, Mexico is paying for the wall. Or if I were here, they would be." -- Trump <a href="https://t.co/Rs3liJmx2B">pic.twitter.com/Rs3liJmx2B</a>
 </p>
 — Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1346282591100563456?ref_src=twsrc%5Etfw">January 5, 2021</a>
 </blockquote>
 </div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PorHuM">
 But beyond caricaturing Perdue and Loeffler’s opponents as radical socialists, Trump failed to explain why his supporters should have much confidence that the runoffs won’t be rigged like he claims the presidential election was.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PiUMq7">
 Overall, as Trump read lines from his pre-presidential stump speech <a href="https://twitter.com/atrupar/status/1346297953858826241">without even bothering to update them</a> to reflect the reality that the election is over and he lost, it became clear he was mostly mailing it in.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lFHiHr">
 “We will never, ever surrender,” Trump <a href="https://twitter.com/atrupar/status/1346298277659074560">said</a> toward the end of his nearly 90-minute speech — and in case it wasn’t obvious, he was talking about himself. Regardless of what happens during Tuesday’s runoffs, for Trump, by Wednesday it will be an afterthought.
 </p>
 <h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>South Africa clinches series as Sri Lanka loses six wickets for 35 runs</strong> - The Proteas achieved the target of 67 runs after having bowled out the Sri Lankans for 211 in their second innings.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs India | Rohit Sharma set to replace Mayank Agarwal in playing XI for 3rd Test</strong> - The team is weighing its options for the third pacer's slot with Shardul Thakur and Navdeep Saini in contention for Sydney</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs India | Warner likely to play, Pukovski set for debut in Sydney: Langer</strong> - Australia’s head coach sought to allay concerns that Warner hasn't played four-day cricket for about 12 months, saying the immense experience that is behind the opener will help him jump into the traditional format without any fuss.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New Zealand vs Pakistan, 2nd Test, Day 3 | Kane Williamson’s 238 puts New Zealand on top against Pakistan</strong> - Williamson briefly delayed his declaration to allow allrounder Daryl Mitchell to reach a maiden Test century</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NBA issues tougher in-game mask policy for players</strong> - Multiple outlets reported the updated policy, citing a memo the league sent to every team.</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ED attaches assets worth ₹452 cr. in fraud case</strong> - They are in the form of 8.86% shares of ILFS Tamil Nadu Power Company Limited (ITPCL).</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Malegaon blast accused Prasad Purohit in home quarantine</strong> - Had attended NIA court on January 4</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mahesh Narayanan: Those with content library will conquer the film industry</strong> - Award-winning editor and director of films such as 'Take Off', 'C U Soon' and 'Malik' tries to predict how filmmaking and watching films are likely to change on account of the pandemic</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CCPA recommends Parliament's Budget session from January 29</strong> - According to the Committee's recommendation, while Part 1 of the Budget session would be held from January 29 to February 15, Part 2 would be from March 8 to April 8</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Assam student group to take anti-CAA fight to Delhi</strong> - “Our objective is to bring different political parties on board,” says leader</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: PM acted 'decisively' on England lockdown - Sunak</strong> - Boris Johnson made the decision on restrictions "in the face of new information", the chancellor says.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: French government vows to speed up vaccinations</strong> - A week into mass vaccinations France has inoculated fewer than 1,000 - far behind Germany.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UK expats prevented from returning home to Spain</strong> - UK nationals resident in Spain say they were wrongly turned back when their flight landed in Barcelona.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: Calais traffic slow as new border controls face first test</strong> - More than €50m (£45m; $61m) has been spent preparing the French side of the Channel for Brexit.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>6,561 metal flowers: One man's Covid tribute</strong> - Geert van der Vossen, a Swedish artist, has created a floral tribute to the country's thousands of coronavirus patients.</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>2020’s most disappointing games, as led by Blizzard’s WarCraft III: Reforged</strong> - Plus five other games, though really, none is as bad as Blizzard's year-long bummer. - <a href="https://arstechnica.com/?p=1732812">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>There are an insane amount of cool space things happening in 2021</strong> - Yeah, we're going to say it. We really think Webb is going to launch this year. - <a href="https://arstechnica.com/?p=1730399">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hackers are exploiting a backdoor built into Zyxel devices. Are you patched?</strong> - Recently discovered account with admin rights is hardcoded into multiple device models. - <a href="https://arstechnica.com/?p=1732882">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gwynne Shotwell talks about selling flight-proven rockets, Starship</strong> - "It was easier to sell 'flight proven' to customers than it was to sell Falcons." - <a href="https://arstechnica.com/?p=1731921">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synchronized violin players reveal uniqueness of human networks</strong> - It's relevant to economics, epidemiology, traffic, and the spread of misinformation. - <a href="https://arstechnica.com/?p=1732761">link</a></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
 <ul>
 <li><strong>I want my 11780 dollars.</strong> - <!-- SC_OFF -->
 <div class="md">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Dear Bank of America, I just want to find 11780 more dollars in my savings account.Everyone at your bank counted wrong.
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/feynarun"> /u/feynarun </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kqrt2p/i_want_my_11780_dollars/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kqrt2p/i_want_my_11780_dollars/">[comments]</a></span></p></li>
 <li><strong>A boy is selling fish on a corner.</strong> - <!-- SC_OFF -->
 <div class="md">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 To get his customers' attention, he begins yelling, "Dam fish for sale! Get your dam fish here!"
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 A pastor hears this and asks, "Why are you calling them 'dam fish.'" The boy responds, "Because I caught these fish at the local dam." The pastor buys a couple fish, takes them home to his wife, and asks her to cook the dam fish.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The wife responds surprised, "I didn't know it was acceptable for a preacher to speak that way." He explains to her why they are dam fish.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Later at the dinner table, he asks his son to pass the dam fish. He responds, "That's the spirit, Dad! Now pass the f*cking potatoes!"
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/esc1999"> /u/esc1999 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kquaxq/a_boy_is_selling_fish_on_a_corner/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kquaxq/a_boy_is_selling_fish_on_a_corner/">[comments]</a></span></p></li>
 <li><strong>I have daily sex</strong> - <!-- SC_OFF -->
 <div class="md">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Edit: I have dyslexia*
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/killtrevor"> /u/killtrevor </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kqep7j/i_have_daily_sex/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kqep7j/i_have_daily_sex/">[comments]</a></span></p></li>
 <li><strong>What vegetable do you need when you get a flat tire?</strong> - <!-- SC_OFF -->
 <div class="md">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 A-spare-I-guess.
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/forkchopsandwiches"> /u/forkchopsandwiches </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kqsw00/what_vegetable_do_you_need_when_you_get_a_flat/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kqsw00/what_vegetable_do_you_need_when_you_get_a_flat/">[comments]</a></span></p></li>
 <li><strong>Guns are like gum...</strong> - <!-- SC_OFF -->
 <div class="md">
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Pull it out in class and everyone acts like you’ve been best friends since kindergarten.
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/CerealKiller979"> /u/CerealKiller979 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kqga7a/guns_are_like_gum/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/kqga7a/guns_are_like_gum/">[comments]</a></span></p></li>
 </ul>
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